CN117561031A - 包括支撑物保持组合件的外科缝合装置 - Google Patents
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- CN117561031A CN117561031A CN202280044552.5A CN202280044552A CN117561031A CN 117561031 A CN117561031 A CN 117561031A CN 202280044552 A CN202280044552 A CN 202280044552A CN 117561031 A CN117561031 A CN 117561031A
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- A—HUMAN NECESSITIES
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- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07207—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
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- A—HUMAN NECESSITIES
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- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
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- A61B2017/07214—Stapler heads
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Landscapes
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Abstract
一种外科缝合装置包括工具组合件和支撑物组合件。工具组合件包括可在闭合构型与打开构型之间转换的第一钳口构件和第二钳口构件。第一钳口构件或第二钳口构件中的至少一者包括保持组合件，该保持组合件包括限定凹部的支撑件。支撑物组合件包括支撑物材料和脊部。支撑物材料包括第一部分和第二部分。脊部包括沿支撑物材料的第一部分和第二部分的长度延伸的细长部分以及以正交关系附接到细长部分的接合部分。接合部分以可拆卸的方式接纳在第一钳口构件或第二钳口构件中的至少一者的保持组合件的支撑件的凹部中。
Description
技术领域
本公开涉及外科缝合装置，并且更具体地涉及用于将缝钉线支撑物组合件以可拆卸的方式固定或保持到外科缝合装置的组合件和方法。
背景技术
外科医生采用外科缝合装置来顺序地或同时地将一排或多排紧固件(例如，缝钉或两件式紧固件)施加到身体组织，以便将身体组织的区段联结在一起。当缝合相对较薄或易碎的组织时，重要的是有效地密封缝钉线以防止空气或流体泄漏。另外，常常需要加固缝钉线以抵抗组织，从而抑制组织中的撕裂或者拉动缝钉穿过组织。一种抑制撕裂或拉穿的方法涉及在缝钉与下面的组织之间放置生物相容性加固材料或“支撑物”材料。在此方法中，将一层支撑物组合件放置在组织上，并且以常规方式缝合组织。
因此，能够容易且有效地附接和移除外科缝合装置的支撑物组合件的新系统和方法将是期望的。
发明内容
本公开描述了包括支撑物保持组合件的外科缝合装置，该外科缝合装置证明了满足性能要求并且克服与将支撑物组合件以可拆卸的方式固定到外科缝合装置相关联的可用性挑战的实用途径。
根据本公开，一种外科缝合装置包括工具组合件和支撑物组合件。工具组合件包括可在闭合构型与打开构型之间转换的第一钳口构件和第二钳口构件。第一钳口构件或第二钳口构件中的至少一者包括保持组合件，该保持组合件包括限定凹部的支撑件。支撑物组合件包括支撑物材料和脊部。支撑物材料包括第一部分和第二部分。脊部包括沿支撑物材料的第一部分和第二部分的长度延伸的细长部分以及以正交关系附接到细长部分的接合部分。接合部分以可拆卸的方式接纳在第一钳口构件或第二钳口构件中的至少一者的保持组合件的支撑件的凹部中。
在一方面，支撑物材料可以包括将支撑物材料的第一部分和第二部分彼此连接的活动铰链。活动铰链可以使第一部分和第二部分偏置背离彼此。
在另一方面，支撑物材料的第一部分和第二部分可以限定V形轮廓。
在又一方面，支撑物材料可以整体地形成。
在又一方面，脊部的接合部分可以从脊部的细长部分的端部部分径向向外延伸。
在一方面，第一钳口构件或第二钳口构件中的至少一者可以具有渐缩端部，并且保持组合件的支撑件可以设置在该渐缩端部上。
在另一方面，保持组合件的支撑件可以具有三角形形状，以减少支撑物材料和脊部的弯曲。
在又一方面，脊部的细长部分可以沿着支撑物材料的周边部分延伸。
在又一方面，支撑物组合件的接合部分可以通过卡扣配合或摩擦配合以可释放的方式固定到保持组合件的支撑件。
在又一方面，支撑物材料的脊部可以是可生物吸收的。
在又一方面，脊部的细长部分的至少一部分可以介于支撑物材料与第一钳口构件或第二钳口构件之间。
根据本公开的另一方面，外科套件包括支撑物组合件、装载组合件和外科缝合装置。支撑物组合件包括支撑物材料和第一脊部。支撑物材料包括第一部分和第二部分。第一脊部包括沿支撑物材料的第一部分和第二部分的长度延伸的细长部分以及从细长部分的相应远侧端部部分横向向外延伸的接合部分。装载组合件包括基座部分和从基座部分延伸的延伸部。基座部分包括在基座部分的相对的两个端部上的第一锚固组合件和第二锚固组合件。支撑物组合件包括围绕装载组合件的延伸部缠绕的部分。支撑物组合件的第一脊部的接合部分以可拆卸的方式固定到装载组合件的基座部分的相应的第一锚固组合件和第二锚固组合件。外科缝合装置包括工具组合件，该工具组合件具有第一钳口构件和第二钳口构件，该第一钳口构件和该第二钳口构件可在闭合构型与打开构型之间转换。第一钳口构件或第二钳口构件包括相应的保持组合件。每个保持组合件包括限定凹部的支撑件，该凹部被构造成以可释放的方式接纳第一脊部的对应的接合部分。
在一方面，支撑物材料可以进一步包括将支撑物材料的第一部分和第二部分互连的活动铰链。活动铰链可以使第一部分和第二部分偏置背离彼此。
在另一方面，支撑物材料可以整体地形成为单个构造。
在又一方面，第一脊部的接合部分可以从细长部分的相应远侧端部部分以正交关系延伸。
在又一方面，支撑在装载组合件上的支撑物组合件可以限定第一角度。第一钳口构件和第二钳口构件在间隔开的构型中可以限定第二角度。第一角度和第二角度可以是相等的。
在又一方面，支撑物组合件可以进一步包括第二脊部。第一脊部和第二脊部可以横向间隔开并且设置在支撑物材料的相对的两个横向侧上。
在一方面，第一钳口构件或第二钳口构件的保持组合件可以包括限定凹部的一对支撑件。
在另一方面，第一脊部或第二脊部可以由生物可吸收材料形成。
在又一方面，外科缝合装置的保持组合件的支撑件可以通过卡扣配合或过盈配合将脊部固定到该支撑件。
附图说明
当结合附图考虑以下详细描述时，本公开的以上和其它方面和特征将变得更加明显，其中相同的附图标记表示类似或相同的元件。
图1是根据本公开的外科缝合装置的透视图；
图2是与外科缝合装置一起使用的图1的支撑物组合件的透视图；
图3是图1的所指示细节区域的放大视图；
图4是图1的外科缝合装置的局部侧视图，展示了固定到外科缝合装置的工具组合件的钳口的支撑物组合件；
图5是图4的所指示细节区域的放大视图；
图6是用于在与图1的外科缝合装置一起使用之前支撑图2的支撑物组合件的装载组合件的透视图；
图7是图6的所指示细节区域的放大视图；
图8和图9是图1的外科缝合装置和图6的装载组合件的局部侧视图，展示了支撑物组合件从装载组合件到外科缝合装置的转移；并且
图10是图9的所指示细节区域的放大视图；
具体实施方式
参考附图详细地描述本文公开的包括支撑物保持组合件的外科缝合装置，其中在若干视图中的每个视图中，相似附图标记指定相同或对应元件。如本文所用，术语“远侧”是指在外科缝合装置的常规使用中所描述的较远离使用者的部分，而术语“近侧”是指在外科缝合装置的常规使用中所描述的较靠近使用者的部分。另外，术语平行和垂直应当被理解为包括与真正的平行和真正的垂直相差至多约+10度或-10度的基本上平行和基本上垂直的相对构型。此外，在一致的程度上，本文详述的方面中的任何或所有方面可以与本文详述的其他方面中的任何或所有方面结合使用。
参考图1，提供了一种外科缝合装置200，该外科缝合装置用于缝合组织并且在缝钉与下面的组织之间施加一层支撑物材料。这层支撑物材料被配置用于加强和密封由外科缝合装置200应用到组织上的缝钉线。外科缝合装置200通常包括手柄202和从手柄202向远侧延伸的细长管状构件204。重载件106可移除地联接到细长管状构件204的远侧端部105。重载件106包括轴部分109和支撑在轴部分109上的工具组合件107。工具组合件107包括第一钳口构件108和第二钳口构件110，该第二钳口构件可相对于第一钳口构件108在打开构型与闭合构型之间移动，打开构型用于将组织定位在第一钳口构件108与第二钳口构件110之间，闭合构型用于将组织夹紧在第一钳口构件108与第二钳口构件110并且随后缝合组织。第一钳口构件108支撑砧座111，并且第二钳口构件110以可释放的方式支撑缝钉仓112。为了将由缝钉仓112提供的缝钉固定到组织和支撑物组合件300上，砧座111设置有纵向布置的成排的缝钉铆接或成形凹坑(未示出)。可以设想，工具组合件107可以联接到机械或机动手柄，并且缝钉仓112可以是可移除的且可更换的。还可以设想重载件106可以是机器人外科系统的一部分。
继续参考图1，外科缝合装置200包括可移动地安装在手柄202上的触发器236。触发器236的致动使工具组合件107从打开构型转变到闭合构型并且随后致动外科缝合装置200以将缝钉线施加到组织。外科缝合装置200进一步包括回缩机构217，该回缩机构可以被手动抓握并且向近侧拉动以使外科缝合装置200的击发机构回缩。为了将工具组合件107相对于要缝合的组织正确地定向，外科缝合装置200另外设置有安装在手柄202上的旋钮234。旋钮234围绕外科缝合装置200的纵向轴线“A-A”的旋转使工具组合件107围绕纵向轴线“A-A”旋转。关于外科缝合装置200的构造和操作的详细讨论，可以参考美国专利申请公布号2014/0263550，该美国专利申请的全部内容以引用方式并入本文。
图1和图2展示了与外科缝合装置200一起使用的支撑物组合件300。支撑物组合件300以可拆卸的方式固定到外科缝合装置200的工具组合件107，以与第一钳口构件108的砧座111和第二钳口构件110的缝钉仓112配准。支撑物组合件300包括支撑物材料310和脊部330。支撑物材料310被配置成加固和密封由外科缝合装置200施加到组织的缝钉线。支撑物材料310包括第一部分312和第二部分316，在该第一部分与该第二部分之间限定有活动铰链318。活动铰链318将第一部分312和第二部分316偏置背离彼此。在一方面，支撑物材料310具有V形。在一方面，支撑物材料310整体地形成为单个构造。在另一方面，支撑物材料310可以由弹性材料形成。脊部330横向间隔开并且沿着支撑物材料310的相对的周边部分延伸。在一些方面，脊部330被设置成将支撑物组合件300以可拆卸的方式固定到第一钳口构件108和第二钳口构件110并且维持支撑物材料310的第一部分312和第二部分316的大致平坦表面。每个脊部330包括沿着支撑物材料310的长度延伸的细长部分332和设置在细长部分332的相对的两个端部处的接合部分336。每个接合部分336从细长部分332横向向外延伸，使得接合部分336例如正交于细长部分332。接合部分336以可拆卸的方式与外科缝合装置200的工具组合件107(图1)接合，如将描述的。特别地，细长部分332从支撑物材料310的第一部分312的远侧端部312a和第二部分316的远侧端部316a向远侧延伸，使得接合部分336与支撑物材料310的第一部分312的远侧端部312a和第二部分316的远侧端部316a间隔开。在一方面，每个脊部330整体地形成为单个构造。在另一方面，脊部330可以由聚合物形成。在另一方面，脊部330可以是生物可吸收的。
支撑物组合件300以可拆卸的方式固定到工具组合件107。为此，第一钳口构件108和第二钳口构件110包括相应的第一保持组合件180和第二保持组合件190，如图3和图4所示。第一保持组合件180包括一对支撑件182。每个支撑件182限定凹部184以接收脊部330的对应的接合部分336。在一方面，接合部分336可以经由(例如)搭扣配合或过盈配合而以可拆卸的方式接纳于凹部184中。在一方面，第一保持组合件180的每个支撑件182可以包括例如三角形形状，以补偿第一钳口108的远侧端部部分的，以便减小脊部330和/或支撑物材料310的弯曲，如图4和图5中最佳所示。图3和图4进一步展示了包括第二保持组合件190的第二钳口构件110。类似于第一保持组合件180，第二保持组合件190包括一对支撑件192。每个支撑件192限定凹部194以接纳脊部330的对应的接合部分336。在一方面，接合部分336可以经由(例如)搭扣配合或过盈配合而以可拆卸的方式接纳于凹部194中。在一方面，每个支撑件192可以包括(例如)三角形形状以补偿第二钳口110的远侧端部部分的渐缩，以便减少脊部330和/或支撑物材料310的弯曲，如图4中最佳所示。
图6和图7展示了在将支撑物组合件300安装到外科缝合装置200上之前以可释放的方式支撑支撑物组合件300的装载组合件600。装载组合件600促进将支撑物组合件300安装在外科缝合装置200的工具组合件107上。装载组合件600包括基座部分610和从基座部分610延伸的延伸部650。特别地，基座部分610包括在基座部分610的相应端部上的锚固部分620、630。锚固部分620、630包括相应的一对支撑件622、632，这对支撑件限定凹部624以以可拆卸的方式接收与支撑物组合件300的第一部分312相关联的脊部330的接合部分336。在一方面，接合部分336可以经由(例如)摩擦配合而支撑于凹部624中。类似地，锚固部分630的一对支撑件632限定凹部634，以以可拆卸的方式接纳脊部330的与支撑物组合件300的第二部分316相关联的接合部分336。在一方面，支撑件622或支撑件632可以间隔开距离“W”，该距离小于或大于由工具组合件107的第一保持组合件180或第二保持组合件190的支撑件182或支撑件192限定的距离“Y”(图3)，使得第一保持组合件180或第二保持组合件190可以被接纳在支撑件622或632内或从支撑件622或632横向向外。
在此类构型下，支撑物组合件300围绕延伸部650缠绕，并且支撑物材料310的远侧端部312a、316a以可拆卸的方式固定到相应的锚固部分620、630。当支撑物组合件300被支撑在装载组合件600上时，支撑物组合件300的第一部分312和第二部分316限定角度α(图6)，该角度与由处于打开构型的第一钳口构件108和第二钳口构件110限定的角度β(图4)大致相同。
如图8所示，在使用之前，支撑物组合件300以可拆卸的方式支撑在装载组合件600上。在使用中，装载组合件600定位在第一钳口部件108与第二钳口部件110之间，钳口部件108、110处于打开构型。此后，第一钳口部件108的第一保持组合件180的支撑件182和第二钳口构件110的第二保持组合件190的支撑件192与装载组合件600的支撑件622、632对准。工具组合件107和装载组合件600进一步朝向彼此移动，直到支撑物组合件300的接合部分336(图2)被接纳在第一保持组合件180的凹部184(图3)和第二保持组合件190的凹部194(图5)中。以这种方式，支撑物组合件300以可释放的方式安装在外科缝合装置200的工具组合件107上。在缝钉已被施加到组织之后，支撑物组合件300被附接到组织，并且支撑物组合件300可通过将工具组合件107拉离组织而与第一保持组合件180和第二保持组合件190脱离。
还可以设想，支撑物组合件300可以由任何生物相容性天然或合成材料制成。形成支撑物组合件300的材料可以是可生物吸收的或不可生物吸收的。应当理解，可以使用天然的、合成的、生物可吸收的和/或非生物可吸收的材料的任何组合来形成支撑物组合件300。
可用于制造支撑物组合件300的材料的非限制性示例包括但不限于：聚(乳酸)、聚(乙醇酸)、聚(羟基丁酸酯)、聚(磷嗪)、聚酯、聚乙二醇、聚氧化乙烯、聚丙烯酰胺、聚羟乙基甲基丙烯酸酯、聚乙烯吡咯烷酮、聚乙烯醇、聚丙烯酸、聚乙酸酯、聚己内酯、聚丙烯、脂肪族聚酯、甘油、聚(氨基酸)、共聚(醚-酯)、聚草酸亚烷基酯、聚酰胺、聚(亚氨基碳酸酯)、聚草酸亚烷基酯、聚氧杂酯、聚原酸酯、聚磷腈和其共聚物、嵌段共聚物、均聚物、共混物和其组合。
在一些方面，天然生物聚合物用于形成支撑物组合件300。适合的天然生物聚合物包括但不限于胶原、明胶、纤维蛋白、纤维蛋白原、弹性蛋白、角蛋白、白蛋白、羟乙基纤维素、纤维素、羟丙基纤维素、甲壳质、壳聚糖和其组合。此外，天然生物聚合物可以与本文所描述的任何其他聚合物材料组合，以产生支撑物组合件300。
支撑物组合件300可以是多孔的或无孔的，或者多孔层和无孔层的组合。在支撑物组合件300是无孔的情况下，支撑物组合件300可以延迟或抑制组织从周围组织向内生长，从而充当粘附屏障并抑制不需要的疤痕组织的形成。因此，在各方面中，支撑物组合件300具有抗粘附特性。由此类材料形成无孔层的技术在本领域技术人员的能力范围内，并且包括例如铸造、模制等。
在一些方面，支撑物组合件300是多孔的并且具有止血特性。在支撑物组合件300是多孔的情况下，支撑物组合件在其表面的至少一部分上具有开口或孔。用于形成多孔层的适合的材料包括但不限于泡沫(例如，开孔泡沫或闭孔泡沫)。在一些方面，孔可以具有足够的数量和大小，以便在多孔层的整个厚度上相互连接。在其他方面中，孔可以不在多孔层的整个厚度上相互连接。在其他方面中，孔不延伸遍及多孔层的整个厚度，而是存在于多孔层的表面的一部分处。在一些方面，开口或孔位于多孔层的表面的一部分上，且多孔层的其他部分具有无孔纹理。阅读本公开内容的本领域技术人员将预见多孔层的其他孔分布模式和构型。
在支撑物组合件300是多孔的情况下，孔可以使用适于形成泡沫或海绵的任何方法(包括但不限于组合物的冻干或冷冻干燥)形成。用于制备泡沫的适合的技术在本领域技术人员的能力范围内。多孔支撑物组合件300可以为至少0.2cm厚，在一些方面为从约0.3cm至约1.5cm厚。多孔支撑物组合件300可以具有不超过约75mg/cm2的密度，并且在一些方面低于约20mg/cm2。多孔支撑物组合件300中的孔的尺寸可以为从约20μm至约300μm，并且在某些方面中为从约100μm至约200μm。
支撑物组合件300还可以包括加固构件。加固构件可以与多孔或无孔层相关联，或者可以定位在支撑物组合件300的无孔层与多孔层之间。替代性地，加固构件可以完全定位在支撑物组合件300的一个或多个单独的层内(例如，嵌入多孔层、无孔层或这两者内)。还可以设想，加固构件可以定位在构成支撑物组合件300的层之一的表面处，并且在一些方面，可以定位在支撑物组合件300的外表面处。
加固构件的一些适合的非限制性示例包括织物、网、单丝、复丝编织物、短切纤维(在本领域中有时称为短纤维)和其组合。在加固构件是网状物的情况下，其可以使用本领域技术人员已知的任何技术来制备，诸如针织、编织、起绒、刀切等。在单丝或复丝编织物用作加固构件的情况下，单丝或复丝编织物可以以任何期望的方式定向。例如，单丝或复丝编织物可以在支撑物组合件300内相对于彼此随机地定位。作为另一个示例，单丝或复丝编织物可以在支撑物组合件300内沿共同的方向定向。当短切纤维用作加固构件时，短切纤维可以以任何期望的方式定向。例如，短切纤维可以是随机定向的或可以以共同方向定向。短切纤维因此可以形成非织造材料，比如垫或毡。短切纤维可以(例如，通过热熔合)联结在一起或者它们可以彼此不附接。短切纤维可以具有任何适当的长度。例如，短切纤维的长度可以为0.1mm至100mm，并且在一些方面可以为0.4mm至50mm。在一方面，支撑物组合件300具有随机定向的短切纤维，这些短切纤维先前没有熔合在一起并且嵌入支撑物组合件300中。
可以设想的是，加固构件可以由本文先前描述的任何可生物吸收的、不可生物吸收的、天然的、或合成的材料和其组合形成。在使用单丝或复丝编织物作为加固构件的情况下，可以有利地使用任何市售缝合材料作为加固构件。
在一些方面，至少一种生物活性剂可以与支撑物组合件300和/或用于构造支撑物组合件300的单独部件(多孔层、无孔层和/或加固构件)中的任一个部件组合。在一些方面，支撑物组合件300还可以用作用于输送生物活性剂的载体。如本文所用，术语“生物活性剂”以其最广义使用，并且包括具有临床用途的任何物质或物质的混合物。因此，生物活性剂本身可以具有或不具有药理学活性，例如染料或香料。替代性地，生物活性剂可以是提供治疗或预防效果的任何试剂，诸如影响或参与组织生长、细胞生长或细胞分化的化合物。
可以根据本公开利用的生物活性剂种类的示例包括抗粘连剂、抗微生物剂、镇痛剂、退热剂、麻醉剂、抗癫痫剂、抗组胺剂、消炎剂、心血管药、诊断剂、拟交感神经剂、拟胆碱剂、抗毒蕈碱剂、镇痉剂、激素、生长因子、肌肉松弛剂、肾上腺素能神经元阻断剂、抗肿瘤剂、免疫原性剂、免疫抑制剂、胃肠药、利尿剂、类固醇、脂质、脂多糖、多糖和酶。还预期可以使用生物活性剂的组合。
抗粘合剂或抗粘附剂可以用于抑制在支撑物组合件300和与目标组织相对的周围组织之间形成粘附。这些试剂的一些示例包括但不限于聚(乙烯基吡咯烷酮)、羧甲基纤维素、透明质酸、聚环氧乙烷、聚乙烯醇和其组合。
可以作为生物活性剂包括在本公开的支撑物组合件300中的适合的抗微生物剂包括三氯生(triclosan)，也称为2,4,4'-三氯-2'-羟基二苯基醚；氯己定(chlorhexidine)和其盐，包括醋酸氯己定(chlorhexidine acetate)、葡萄糖酸氯己定(chlorhexidinegluconate)、盐酸氯己定(chlorhexidine hydrochloride)和硫酸氯己定(chlorhexidinesulfate)；银和其盐，包括乙酸银、苯甲酸银、碳酸银、柠檬酸银、碘酸银、碘化银、乳酸银、月桂酸银、硝酸银、氧化银、棕榈酸银、银蛋白和磺胺嘧啶银(silver sulfadiazine)；多粘菌素(polymyxin)；四环素(tetracycline)；氨基糖苷类，例如妥布霉素(tobramycin)和庆大霉素(gentamicin)；利福平(rifampicin)；杆菌肽(bacitracin)；新霉素(neomycin)；氯霉素(chloramphenicol)；咪康唑(miconazole)；喹诺酮类，例如恶喹酸(oxolinic acid)、诺氟沙星(norfloxacin)、萘啶酸(nalidixic acid)、培氟沙星(pefloxacin)、依诺沙星(enoxacin)和环丙沙星(ciprofloxacin)；青霉素类，例如苯唑西林(oxacillin)和哌拉西林(pipracil)；壬苯醇醚9(nonoxynol 9)；夫西地酸(fusidic acid)；头孢菌素(cephalosporin)；和其组合。此外，抗微生物蛋白质和诸如牛乳铁蛋白和乳铁蛋白肽B等肽可以作为生物活性剂包括在本公开的生物活性涂层中。
可以作为生物活性剂包括在根据本公开的支撑物组合件300中的其他生物活性剂包括：局部麻醉剂；非类固醇抗生育剂；拟副交感神经剂；精神治疗剂；镇静剂；解充血剂；镇静催眠剂；类固醇；磺酰胺；拟交感神经剂；疫苗；维生素；抗疟剂；抗偏头痛剂；抗帕金森剂，诸如L-多巴；镇痉药；抗胆碱能剂(例如，奥昔布宁)；止咳药；支气管扩张剂；冠状动脉血管扩张剂、硝酸甘油等心血管药物；生物碱；镇痛剂；麻醉剂，诸如可待因、二氢可待因酮、度冷丁、吗啡等；非麻醉剂，诸如水杨酸盐、阿司匹林、对乙酰氨基酚、右旋丙氧芬等；阿片样物质受体拮抗剂，诸如纳曲酮和纳洛酮；抗癌剂；抗惊厥药；止吐药；抗组胺剂；抗炎剂，诸如激素剂、氢化可的松、泼尼松龙、泼尼松、非激素剂、别嘌呤醇、消炎痛、保泰松等；前列腺素和细胞毒性药物；雌激素；抗菌剂；抗生素；抗真菌剂；抗病毒剂；抗凝血剂；抗惊厥药；抗抑郁药；抗组胺剂；和免疫剂。
可以包括在涂层组合物中的适合的生物活性剂的其他示例包括病毒和细胞、肽、多肽和蛋白质、类似物、突变蛋白和其活性片段，诸如免疫球蛋白、抗体、细胞因子(例如，淋巴因子、单核因子、趋化因子)、凝血因子、造血因子、白介素(IL-2、IL-3、IL-4、IL-6)、干扰素(β-IFN、(α-IFN和γ-IFN)、红细胞生成素、核酸酶、肿瘤坏死因子、集落刺激因子(例如，GCSF、GM-CSF、MCSF)、胰岛素、抗肿瘤剂和肿瘤抑制剂、血蛋白、促性腺激素(例如，FSH、LH、CG等)、激素和激素类似物(例如，生长激素)、疫苗(例如，肿瘤、细菌和病毒抗原)；促生长素抑制素；抗原；凝血因子；生长因子(例如，神经生长因子、胰岛素样生长因子)；蛋白抑制剂、蛋白拮抗剂和蛋白激动剂；核酸，诸如反义分子、DNA和RNA；寡核苷酸；多核苷酸；和核酶。
虽然在附图中示出了本公开，但是不意图将本公开限于此，因为预期本公开的范围与本领域将允许的范围一样宽并应当以同样方式阅读本说明书。因此，以上描述不应当被解释为限制性的，而是仅作为范例。本领域的技术人员能够设想在本文所附权利要求书的范围和实质内的其他修改。
Claims (20)
1.一种外科缝合装置，包括：
工具组合件，所述工具组合件包括能够在闭合构型与打开构型之间转换的第一钳口构件和第二钳口构件，所述第一钳口构件或所述第二钳口构件中的至少一者包括保持组合件，所述保持组合件包括限定凹部的支撑件；和
支撑物组合件，所述支撑物组合件包括：
支撑物材料，所述支撑物材料包括第一部分和第二部分；和
脊部，所述脊部包括细长部分和接合部分，所述细长部分沿着所述支撑物材料的所述第一部分和所述第二部分的长度延伸，所述接合部分以正交关系附接到所述细长部分，所述接合部分以可拆卸的方式接纳在所述第一钳口构件或所述第二钳口构件中的至少一者的所述保持组合件的所述支撑件的凹部中。
2.根据权利要求1所述的外科缝合装置，其中所述支撑物材料包括活动铰链，所述活动铰链将所述支撑物材料的所述第一部分和所述第二部分彼此连接，所述活动铰链使所述第一部分和所述第二部分偏置背离彼此。
3.根据权利要求1所述的外科缝合装置，其中所述支撑物材料的所述第一部分和所述第二部分限定V形轮廓。
4.根据权利要求1所述的外科缝合装置，其中所述支撑物材料整体地形成。
5.根据权利要求1所述的外科缝合装置，其中所述脊部的所述接合部分从所述脊部的所述细长部分的端部部分径向向外延伸。
6.根据权利要求1所述的外科缝合装置，其中所述第一钳口构件或所述第二钳口构件中的至少一者具有渐缩端部，并且所述保持组合件的所述支撑件设置在所述渐缩端部上。
7.根据权利要求6所述的外科缝合装置，其中所述保持组合件的所述支撑件具有三角形形状以减小所述支撑物材料和所述脊部的弯曲。
8.根据权利要求1所述的外科缝合装置，其中所述脊部的所述细长部分沿着所述支撑物材料的外周部分延伸。
9.根据权利要求1所述的外科缝合装置，其中所述支撑物组合件的所述接合部分通过卡扣配合或摩擦配合以可释放的方式固定至所述保持组合件的所述支撑件。
10.根据权利要求1所述的外科缝合装置，其中所述支撑物材料的所述脊部是生物可吸收的。
11.根据权利要求1所述的外科缝合装置，其中所述脊部的所述细长部分的至少一部分介于所述支撑物材料与所述第一钳口构件或第二钳口构件之间。
12.一种外科套件，包括：
支撑物组合件，所述支撑物组合件包括：
支撑物材料，所述支撑物材料包括第一部分和第二部分；和
第一脊部，所述第一脊部包括细长部分和接合部分，所述细长部分沿所述支撑物材料的所述第一部分和所述第二部分的长度延伸，所述接合部分从所述细长部分的相应的远侧端部部分横向向外延伸；
装载组合件，所述装载组合件包括基座部分和从所述基座部分延伸的延伸部，所述基座部分包括在所述基座部分的相对的两个端部上的第一锚固组合件和第二锚固组合件，所述支撑物组合件包括围绕所述装载组合件的所述延伸部缠绕的部分，所述支撑物组合件的所述第一脊部的所述接合部分以可拆卸的方式固定到所述装载组合件的所述基座部分的相应的第一锚固组合件和第二锚固组合件；和
外科缝合装置，所述外科缝合装置包括工具组合件，所述工具组合件具有能够在闭合构型与打开构型之间转换的第一钳口构件和第二钳口构件，所述第一钳口构件或所述第二钳口构件包括相应的保持组合件，每个保持组合件包括限定凹部的支撑件，所述凹部被构造成以可释放的方式接纳所述第一脊部的对应的接合部分。
13.根据权利要求12所述的外科套件，其中所述支撑物材料还包括将所述支撑物材料的所述第一部分和所述第二部分互连的活动铰链，所述活动铰链将所述第一部分和所述第二部分偏置背离彼此。
14.根据权利要求12所述的外科套件，其中所述支撑物材料整体地形成为单个构造。
15.根据权利要求12所述的外科套件，其中所述第一脊部的所述接合部分以正交关系从所述细长部分的相应的远侧端部延伸。
16.根据权利要求12所述的外科套件，其中支撑在所述装载组合件上的所述支撑物组合件限定第一角度，所述第一钳口构件和所述钳口构件在间隔开的构型中限定第二角度，所述第一角度和所述第二角度是相等的。
17.根据权利要求12所述的外科套件，其中所述支撑物组合件还包括第二脊部，所述第一脊部和所述第二脊部侧向间隔开并且设置在所述支撑物材料的相对的侧向侧上。
18.根据权利要求17所述的外科套件，其中所述第一钳口构件或所述第二钳口构件的所述保持组合件包括限定凹部的一对支撑件。
19.根据权利要求17所述的外科套件，其中所述第一脊部或所述第二脊部由生物可吸收的材料形成。
20.根据权利要求12所述的外科套件，其中所述外科缝合装置的所述保持组合件的所述支撑件通过卡扣配合或过盈配合将所述脊部固定到所述保持组合件。
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Family Cites Families (372)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3124136A (en) | 1964-03-10 | Method of repairing body tissue | ||
| DE1602563U (de) | 1949-08-01 | 1950-03-02 | Lebrecht Langenohl | S-foermiger, federnder fraeser zum reinigen von tabakpfeifenkoepfen. |
| US3054406A (en) | 1958-10-17 | 1962-09-18 | Phillips Petroleum Co | Surgical mesh |
| US3364200A (en) | 1960-03-28 | 1968-01-16 | Johnson & Johnson | Oxidized cellulose product and method for preparing the same |
| US3499591A (en) | 1967-06-23 | 1970-03-10 | United States Surgical Corp | Instrument for placing lateral gastro-intestinal anastomoses |
| US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| DE2415728A1 (de) | 1973-04-13 | 1975-01-02 | Teijin Ltd | Traegerfuer fluessiges lichtempfindliches hharz |
| US3939068A (en) | 1973-12-06 | 1976-02-17 | The United States Of America As Represented By The Secretary Of The Army | Process for treating waste water containing cellulose nitrate particles |
| US4064062A (en) | 1975-12-15 | 1977-12-20 | Colgate-Palmolive | Stabilized activated percompound bleaching compositions and methods for manufacture thereof |
| US4416698A (en) | 1977-07-26 | 1983-11-22 | Akzona Incorporated | Shaped cellulose article prepared from a solution containing cellulose dissolved in a tertiary amine N-oxide solvent and a process for making the article |
| US4166800A (en) | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
| US4282236A (en) | 1979-11-07 | 1981-08-04 | Beecham Group Limited | β-Lactam antibacterial agents, their use in pharmaceutical compositions, and intermediates |
| US4429695A (en) | 1980-02-05 | 1984-02-07 | United States Surgical Corporation | Surgical instruments |
| US4347847A (en) | 1980-06-06 | 1982-09-07 | Usher Francis C | Method of hernia repair |
| US4452245A (en) | 1980-06-06 | 1984-06-05 | Usher Francis C | Surgical mesh and method |
| US4354628A (en) | 1980-09-29 | 1982-10-19 | United States Surgical Corporation | Surgical stapler apparatus having pivotally related staple holder and anvil |
| US4605730A (en) | 1982-10-01 | 1986-08-12 | Ethicon, Inc. | Surgical articles of copolymers of glycolide and ε-caprolactone and methods of producing the same |
| US4633873A (en) | 1984-04-26 | 1987-01-06 | American Cyanamid Company | Surgical repair mesh |
| US4626253A (en) | 1984-10-05 | 1986-12-02 | Johnson & Johnson Products, Inc. | Surgical hemostat comprising oxidized cellulose |
| US4655221A (en) | 1985-05-06 | 1987-04-07 | American Cyanamid Company | Method of using a surgical repair mesh |
| US5002551A (en) | 1985-08-22 | 1991-03-26 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
| SE450087B (sv) | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
| US4834090A (en) | 1987-03-02 | 1989-05-30 | Moore J Paul | Suture boot |
| US5285944A (en) | 1987-05-26 | 1994-02-15 | United States Surgical Corporation | Surgical stapler apparatus |
| CA1335527C (en) | 1988-02-01 | 1995-05-16 | Arnold Lee Dellon | Bioabsorbable surgical device for treating nerve defects |
| US5112496A (en) | 1988-11-02 | 1992-05-12 | Petrolite Corporation | Methods for inhibition of scale in high brine environments |
| WO1990005489A1 (en) | 1988-11-18 | 1990-05-31 | Immuno Sweden Ab | Instrument for anastomosis |
| US5306500A (en) | 1988-11-21 | 1994-04-26 | Collagen Corporation | Method of augmenting tissue with collagen-polymer conjugates |
| US5550187A (en) | 1988-11-21 | 1996-08-27 | Collagen Corporation | Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
| US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
| US4930674A (en) | 1989-02-24 | 1990-06-05 | Abiomed, Inc. | Surgical stapler |
| US5318221A (en) | 1989-05-26 | 1994-06-07 | United States Surgical Corporation | Apparatus and method for placing staples in laparoscopic or endoscopic procedures |
| US5040715B1 (en) | 1989-05-26 | 1994-04-05 | United States Surgical Corp | Apparatus and method for placing staples in laparoscopic or endoscopic procedures |
| US5014899A (en) | 1990-03-30 | 1991-05-14 | United States Surgical Corporation | Surgical stapling apparatus |
| US5057334A (en) | 1990-07-13 | 1991-10-15 | Ort's Inc. | Process for recovery of cellulose |
| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5344454A (en) | 1991-07-24 | 1994-09-06 | Baxter International Inc. | Closed porous chambers for implanting tissue in a host |
| US5314471A (en) | 1991-07-24 | 1994-05-24 | Baxter International Inc. | Tissue inplant systems and methods for sustaining viable high cell densities within a host |
| US5690675A (en) | 1991-02-13 | 1997-11-25 | Fusion Medical Technologies, Inc. | Methods for sealing of staples and other fasteners in tissue |
| US5065929A (en) | 1991-04-01 | 1991-11-19 | Ethicon, Inc. | Surgical stapler with locking means |
| US6773458B1 (en) | 1991-07-24 | 2004-08-10 | Baxter International Inc. | Angiogenic tissue implant systems and methods |
| GR920100358A (el) | 1991-08-23 | 1993-06-07 | Ethicon Inc | Οργανο συρραφής χειρουργικής αναστομώσεως. |
| CA2075141C (en) | 1991-10-17 | 1998-06-30 | Donald A. Morin | Anvil for surgical staplers |
| US5443198A (en) | 1991-10-18 | 1995-08-22 | United States Surgical Corporation | Surgical fastener applying apparatus |
| US5312023A (en) | 1991-10-18 | 1994-05-17 | United States Surgical Corporation | Self contained gas powered surgical apparatus |
| US5307976A (en) | 1991-10-18 | 1994-05-03 | Ethicon, Inc. | Linear stapling mechanism with cutting means |
| US5332142A (en) | 1991-10-18 | 1994-07-26 | Ethicon, Inc. | Linear stapling mechanism with cutting means |
| US5326013A (en) | 1991-10-18 | 1994-07-05 | United States Surgical Corporation | Self contained gas powered surgical apparatus |
| US5766246A (en) | 1992-05-20 | 1998-06-16 | C. R. Bard, Inc. | Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis |
| WO1995016221A1 (en) | 1992-06-12 | 1995-06-15 | Boit, Inc. | Liquid crystal color modulation displays |
| US5263629A (en) | 1992-06-29 | 1993-11-23 | Ethicon, Inc. | Method and apparatus for achieving hemostasis along a staple line |
| US5281197A (en) | 1992-07-27 | 1994-01-25 | Symbiosis Corporation | Endoscopic hemostatic agent delivery system |
| US5330486A (en) | 1992-07-29 | 1994-07-19 | Wilk Peter J | Laparoscopic or endoscopic anastomosis technique and associated instruments |
| US5514379A (en) | 1992-08-07 | 1996-05-07 | The General Hospital Corporation | Hydrogel compositions and methods of use |
| CA2108605A1 (en) | 1992-10-21 | 1994-04-22 | Nagabhushanam Totakura | Bioabsorbable foam pledget |
| US5468253A (en) | 1993-01-21 | 1995-11-21 | Ethicon, Inc. | Elastomeric medical device |
| US5397324A (en) | 1993-03-10 | 1995-03-14 | Carroll; Brendan J. | Surgical stapler instrument and method for vascular hemostasis |
| US5415334A (en) | 1993-05-05 | 1995-05-16 | Ethicon Endo-Surgery | Surgical stapler and staple cartridge |
| GB9317490D0 (en) | 1993-08-23 | 1993-10-06 | Hercules Inc | Diaper barrier leg-cuff fabrics |
| US5441193A (en) | 1993-09-23 | 1995-08-15 | United States Surgical Corporation | Surgical fastener applying apparatus with resilient film |
| US5542594A (en) | 1993-10-06 | 1996-08-06 | United States Surgical Corporation | Surgical stapling apparatus with biocompatible surgical fabric |
| CA2132917C (en) | 1993-10-07 | 2004-12-14 | John Charles Robertson | Circular anastomosis device |
| RU2136319C1 (ru) | 1993-12-23 | 1999-09-10 | Джонсон энд Джонсон Медикал, Инк. | Биоабсорбируемое хирургическое гемостатическое средство и способ его получения (варианты) |
| US5503638A (en) | 1994-02-10 | 1996-04-02 | Bio-Vascular, Inc. | Soft tissue stapling buttress |
| US6704210B1 (en) | 1994-05-20 | 2004-03-09 | Medtronic, Inc. | Bioprothesis film strip for surgical stapler and method of attaching the same |
| US5814057A (en) | 1994-06-03 | 1998-09-29 | Gunze Limited | Supporting element for staple region |
| JP3568207B2 (ja) | 1994-06-17 | 2004-09-22 | ハートポート インコーポレイテッド | 外科用ステープル打ち器具 |
| US5833695A (en) * | 1994-07-13 | 1998-11-10 | Yoon; Inbae | Surgical stapling system and method of applying staples from multiple staple cartridges |
| EP0773971B1 (en) | 1994-07-27 | 1999-06-23 | W.L. Gore & Associates, Inc. | High strength porous ptfe sheet material |
| US6280453B1 (en) | 1994-09-29 | 2001-08-28 | Bard Asdi Inc. | Hernia mesh patch with stiffener line segment |
| US6030392A (en) | 1995-01-18 | 2000-02-29 | Motorola, Inc. | Connector for hollow anatomical structures and methods of use |
| JP3795100B2 (ja) | 1995-05-08 | 2006-07-12 | 株式会社伊垣医療設計 | 医療用縫合材 |
| JP3526487B2 (ja) | 1995-05-08 | 2004-05-17 | 株式会社伊垣医療設計 | 医療用縫合材 |
| US5895415A (en) | 1995-06-06 | 1999-04-20 | Optobionics Corporation | Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system |
| WO1997001989A1 (en) | 1995-07-03 | 1997-01-23 | Frater Dirk A | System for mounting bolster material on tissue staplers |
| ATE254892T1 (de) | 1995-07-17 | 2003-12-15 | Alfred Edward Wood | Versteifung für eine herzklappenrekonstruktion |
| US5810855A (en) | 1995-07-21 | 1998-09-22 | Gore Enterprise Holdings, Inc. | Endoscopic device and method for reinforcing surgical staples |
| US5702409A (en) | 1995-07-21 | 1997-12-30 | W. L. Gore & Associates, Inc. | Device and method for reinforcing surgical staples |
| US6032849A (en) | 1995-08-28 | 2000-03-07 | United States Surgical | Surgical stapler |
| US5762256A (en) | 1995-08-28 | 1998-06-09 | United States Surgical Corporation | Surgical stapler |
| US5782396A (en) | 1995-08-28 | 1998-07-21 | United States Surgical Corporation | Surgical stapler |
| AU7398196A (en) | 1995-10-11 | 1997-04-30 | Fusion Medical Technologies, Inc. | Device and method for sealing tissue |
| DE69633411T2 (de) | 1995-10-13 | 2005-10-20 | Transvascular, Inc., Menlo Park | Verfahren und vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe |
| US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| ES2420106T3 (es) | 1995-12-18 | 2013-08-22 | Angiodevice International Gmbh | Composiciones de polímeros reticulados y métodos para su uso |
| US20020068949A1 (en) | 1996-02-23 | 2002-06-06 | Williamson Warren P. | Extremely long wire fasteners for use in minimally invasive surgery and means and method for handling those fasteners |
| US6677258B2 (en) | 1996-05-29 | 2004-01-13 | E. I. Du Pont De Nemours And Company | Breathable composite sheet structure and absorbent articles utilizing same |
| US7307031B2 (en) | 1997-05-29 | 2007-12-11 | The Procter & Gamble Company | Breathable composite sheet structure and absorbent articles utilizing same |
| US6500777B1 (en) | 1996-06-28 | 2002-12-31 | Ethicon, Inc. | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
| TW308613B (en) | 1996-08-19 | 1997-06-21 | Jyi-Shyang Wang | Manufacturing method and device for carbon fabric absorbent |
| US7009034B2 (en) | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
| US5752965A (en) | 1996-10-21 | 1998-05-19 | Bio-Vascular, Inc. | Apparatus and method for producing a reinforced surgical fastener suture line |
| US5769892A (en) | 1996-10-22 | 1998-06-23 | Mitroflow International Inc. | Surgical stapler sleeve for reinforcing staple lines |
| US5931847A (en) | 1997-01-09 | 1999-08-03 | Ethicon Endo-Surgery, Inc. | Surgical cutting instrument with improved cutting edge |
| AU6444298A (en) | 1997-03-04 | 1998-09-22 | Medtronic, Inc. | Bioprothesis film strip for surgical stapler and method of attaching the same |
| FR2762207B1 (fr) | 1997-04-17 | 1999-07-30 | Ethnor | Perfectionnements aux protheses sous-cutanees pour plastie mammaire |
| US6120539A (en) | 1997-05-01 | 2000-09-19 | C. R. Bard Inc. | Prosthetic repair fabric |
| US6433154B1 (en) | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
| US5997895A (en) | 1997-09-16 | 1999-12-07 | Integra Lifesciences Corporation | Dural/meningeal repair product using collagen matrix |
| US5865361A (en) | 1997-09-23 | 1999-02-02 | United States Surgical Corporation | Surgical stapling apparatus |
| NL1007349C2 (nl) | 1997-10-24 | 1999-04-27 | Suyker Wilhelmus Joseph Leonardus | Systeem voor het mechanisch vervaardigen van anastomoses tussen holle structuren; alsmede inrichting en applicator voor gebruik daarbij. |
| PT1028877E (pt) | 1997-11-14 | 2003-01-31 | Continental Teves Ag & Co Ohg | Dispositivo de transmissao da forca de travagem nomeadamente para veiculos automoveis |
| AU1923199A (en) | 1997-12-17 | 1999-07-05 | Hemodynamics, Inc. | Sealing media for surgery and wound closure |
| US6007552A (en) | 1997-12-18 | 1999-12-28 | Minumys | Vascular clamps and surgical retractors with directional filaments for tissue engagement |
| DE19757958A1 (de) | 1997-12-24 | 1999-07-01 | Lurgi Zimmer Ag | Verfahren zur Herstellung einer Cellulosecarbamatlösung |
| US6099551A (en) | 1998-03-12 | 2000-08-08 | Shelhigh, Inc. | Pericardial strip and stapler assembly for dividing and sealing visceral tissues and method of use thereof |
| US6156677A (en) | 1998-03-25 | 2000-12-05 | Kimberly-Clark Worldwide, Inc. | Cellulose-Based medical packaging material sterilizable by oxidizing gas plasma |
| US6517566B1 (en) | 1998-05-11 | 2003-02-11 | Surgical Connections, Inc. | Devices and methods for treating e.g. urinary stress incontinence |
| EP1077647A2 (en) | 1998-05-11 | 2001-02-28 | Claire T. Hovland | Devices and methods for treating e.g. urinary stress incontinence |
| US20050021085A1 (en) | 1998-05-11 | 2005-01-27 | Surgical Connections, Inc. | Surgical stabilizer devices and methods |
| GB9810236D0 (en) | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
| US6669735B1 (en) | 1998-07-31 | 2003-12-30 | Davol, Inc. | Prosthesis for surgical treatment of hernia |
| JP2003524443A (ja) | 1998-08-02 | 2003-08-19 | スーパー ディメンション リミテッド | 医療用体内誘導装置 |
| US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
| US6605294B2 (en) | 1998-08-14 | 2003-08-12 | Incept Llc | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels |
| EP1104324B8 (en) | 1998-08-14 | 2011-06-22 | Incept Llc | Apparatus for in situ formation of hydrogels |
| US7347850B2 (en) | 1998-08-14 | 2008-03-25 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
| US6703047B2 (en) | 2001-02-02 | 2004-03-09 | Incept Llc | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use |
| US6818018B1 (en) | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| US6179862B1 (en) | 1998-08-14 | 2001-01-30 | Incept Llc | Methods and apparatus for in situ formation of hydrogels |
| US6152943A (en) | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| DE19836950B4 (de) | 1998-08-17 | 2004-09-02 | Deutsches Zentrum für Luft- und Raumfahrt e.V. | Chirurgisches Instrument in Form eines Nahtklammergerätes |
| JP2002526188A (ja) | 1998-09-24 | 2002-08-20 | スーパー ディメンション リミテッド | 体内への医療処置中にカテーテルの位置を判定するためのシステム及び方法 |
| US7662409B2 (en) | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US6299631B1 (en) | 1998-11-12 | 2001-10-09 | Poly-Med, Inc. | Polyester/cyanoacrylate tissue adhesive formulations |
| US6142933A (en) | 1998-11-23 | 2000-11-07 | Ethicon Endo-Surgery, Inc. | Anoscope for hemorrhoidal surgery |
| CA2353642C (en) | 1998-12-04 | 2009-11-10 | Amarpreet S. Sawhney | Biocompatible crosslinked polymers |
| JP3531000B2 (ja) | 1998-12-07 | 2004-05-24 | グンゼ株式会社 | 吻合補綴材 |
| US6312457B1 (en) | 1999-04-01 | 2001-11-06 | Boston Scientific Corporation | Intraluminal lining |
| CA2373636A1 (en) | 1999-05-11 | 2000-11-16 | Craig Berky | Surgical clamp devices and methods especially useful in cardiac surgery |
| DE19924311A1 (de) | 1999-05-27 | 2000-11-30 | Walter A Rau | Klammerschneidegerät und Zusatzvorrichtung für ein solches |
| US6723428B1 (en) | 1999-05-27 | 2004-04-20 | Foss Manufacturing Co., Inc. | Anti-microbial fiber and fibrous products |
| US8025199B2 (en) | 2004-02-23 | 2011-09-27 | Tyco Healthcare Group Lp | Surgical cutting and stapling device |
| US6325810B1 (en) | 1999-06-30 | 2001-12-04 | Ethicon, Inc. | Foam buttress for stapling apparatus |
| US6927315B1 (en) | 1999-07-30 | 2005-08-09 | 3M Innovative Properties Company | Adhesive composite having distinct phases |
| US6080169A (en) | 1999-08-10 | 2000-06-27 | Turtel; Lawrence | Strabismus recession clamp |
| US6702828B2 (en) | 1999-09-01 | 2004-03-09 | Converge Medical, Inc. | Anastomosis system |
| US6312474B1 (en) | 1999-09-15 | 2001-11-06 | Bio-Vascular, Inc. | Resorbable implant materials |
| US6627749B1 (en) | 1999-11-12 | 2003-09-30 | University Of Iowa Research Foundation | Powdered oxidized cellulose |
| US6302897B1 (en) | 1999-11-19 | 2001-10-16 | Ethicon, Inc. | Device for deploying medical textiles |
| US6436030B2 (en) | 2000-01-31 | 2002-08-20 | Om P. Rehil | Hiatal hernia repair patch and method for using the same |
| US6273897B1 (en) | 2000-02-29 | 2001-08-14 | Ethicon, Inc. | Surgical bettress and surgical stapling apparatus |
| EP1142535B1 (en) | 2000-04-07 | 2012-10-03 | Collagen Matrix, Inc. | Embolization device |
| US7241300B2 (en) | 2000-04-29 | 2007-07-10 | Medtronic, Inc, | Components, systems and methods for forming anastomoses using magnetism or other coupling means |
| US7232449B2 (en) | 2000-04-29 | 2007-06-19 | Medtronic, Inc. | Components, systems and methods for forming anastomoses using magnetism or other coupling means |
| AU782756B2 (en) | 2000-05-12 | 2005-08-25 | Systagenix Wound Management Ip Co. B.V. | Solid composition exhibiting selective binding to dissolved iron |
| CN1830536A (zh) | 2000-05-16 | 2006-09-13 | 明尼苏达大学评议会 | 采用多喷嘴喷射产生大批生产量的颗粒 |
| US6896684B2 (en) | 2000-06-12 | 2005-05-24 | Niti Medical Technologies Ltd. | Surgical clip applicator device |
| US6610006B1 (en) | 2000-07-25 | 2003-08-26 | C. R. Bard, Inc. | Implantable prosthesis |
| EP1304963A2 (en) | 2000-07-31 | 2003-05-02 | Sumit Roy | Device, apparatus, and prosthesis for suturless anastomosis |
| US6746458B1 (en) | 2000-09-07 | 2004-06-08 | William G. Cloud | Mesh material to repair hernias |
| US7334717B2 (en) | 2001-10-05 | 2008-02-26 | Tyco Healthcare Group Lp | Surgical fastener applying apparatus |
| US7909837B2 (en) | 2000-12-13 | 2011-03-22 | Medtronic, Inc. | Methods, devices and systems for forming magnetic anastomoses |
| JP2002202213A (ja) | 2000-12-28 | 2002-07-19 | Yaskawa Electric Corp | 締め付け圧力検出方法 |
| US7595392B2 (en) | 2000-12-29 | 2009-09-29 | University Of Iowa Research Foundation | Biodegradable oxidized cellulose esters |
| US20020091397A1 (en) | 2001-01-05 | 2002-07-11 | Te-Chuan Chen | Structure of intestinal anastomosis gun |
| US6568398B2 (en) | 2001-03-07 | 2003-05-27 | Edgar C. Cohen | Method for hemostasis |
| US8033983B2 (en) | 2001-03-09 | 2011-10-11 | Boston Scientific Scimed, Inc. | Medical implant |
| US7025772B2 (en) | 2001-03-09 | 2006-04-11 | Scimed Life Systems, Inc. | System for implanting an implant and method thereof |
| US6551356B2 (en) | 2001-03-19 | 2003-04-22 | Ethicon, Inc. | Pocketed hernia repair |
| GB0108088D0 (en) | 2001-03-30 | 2001-05-23 | Browning Healthcare Ltd | Surgical implant |
| US6638285B2 (en) | 2001-04-16 | 2003-10-28 | Shlomo Gabbay | Biological tissue strip and system and method to seal tissue |
| FI20010898A0 (fi) | 2001-04-30 | 2001-04-30 | Ylae Herttuala Seppo | Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi |
| US6592597B2 (en) | 2001-05-07 | 2003-07-15 | Ethicon Endo-Surgery, Inc. | Adhesive for attaching buttress material to a surgical fastening device |
| US6503257B2 (en) | 2001-05-07 | 2003-01-07 | Ethicon Endo-Surgery, Inc. | Method for releasing buttress material attached to a surgical fastening device |
| US7247338B2 (en) | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
| US6454780B1 (en) | 2001-06-21 | 2002-09-24 | Scimed Life Systems, Inc. | Aneurysm neck obstruction device |
| US20030181927A1 (en) | 2001-06-21 | 2003-09-25 | Wallace Michael P. | Aneurysm neck obstruction device |
| US6726706B2 (en) | 2001-06-26 | 2004-04-27 | Steven Dominguez | Suture tape and method for use |
| US20030065345A1 (en) | 2001-09-28 | 2003-04-03 | Kevin Weadock | Anastomosis devices and methods for treating anastomotic sites |
| US7108701B2 (en) | 2001-09-28 | 2006-09-19 | Ethicon, Inc. | Drug releasing anastomosis devices and methods for treating anastomotic sites |
| US7892247B2 (en) | 2001-10-03 | 2011-02-22 | Bioconnect Systems, Inc. | Devices and methods for interconnecting vessels |
| US7087065B2 (en) | 2001-10-04 | 2006-08-08 | Ethicon, Inc. | Mesh for pelvic floor repair |
| DE10155490A1 (de) | 2001-11-13 | 2003-05-22 | Zf Lemfoerder Metallwaren Ag | Kraftverbindungsstrebe |
| US7649089B2 (en) | 2001-12-06 | 2010-01-19 | University Of Iowa Research Foundation | Biodegradable oxidized cellulose esters and their uses as microspheres |
| US6939358B2 (en) | 2001-12-20 | 2005-09-06 | Gore Enterprise Holdings, Inc. | Apparatus and method for applying reinforcement material to a surgical stapler |
| US20030125676A1 (en) | 2001-12-28 | 2003-07-03 | Becton, Dickinson And Company | Medical needle assemblies |
| US6790213B2 (en) | 2002-01-07 | 2004-09-14 | C.R. Bard, Inc. | Implantable prosthesis |
| US7128748B2 (en) | 2002-03-26 | 2006-10-31 | Synovis Life Technologies, Inc. | Circular stapler buttress combination |
| US7377928B2 (en) | 2002-04-15 | 2008-05-27 | Cook Biotech Incorporated | Apparatus and method for producing a reinforced surgical staple line |
| EP1494601B1 (en) | 2002-04-15 | 2012-01-11 | Tyco Healthcare Group LP | Instrument introducer |
| US7517356B2 (en) | 2002-04-16 | 2009-04-14 | Tyco Healthcare Group Lp | Surgical stapler and method |
| US6843252B2 (en) | 2002-04-23 | 2005-01-18 | Samuel W. Harrison | Surgical drape |
| WO2003090631A1 (en) | 2002-04-24 | 2003-11-06 | Surgical Connections, Inc. | Resection and anastomosis devices and methods |
| US6736823B2 (en) | 2002-05-10 | 2004-05-18 | C.R. Bard, Inc. | Prosthetic repair fabric |
| EP1503671B1 (en) | 2002-05-10 | 2006-10-11 | Tyco Healthcare Group Lp | Wound closure material applicator and stapler |
| US6736854B2 (en) | 2002-05-10 | 2004-05-18 | C. R. Bard, Inc. | Prosthetic repair fabric with erosion resistant edge |
| ES2268384T3 (es) | 2002-06-17 | 2007-03-16 | Tyco Healthcare Group Lp | Estructuras anulares de soporte. |
| JP3680050B2 (ja) | 2002-09-18 | 2005-08-10 | 株式会社東芝 | 医療用マニピュレータ及びその制御方法 |
| AU2003279854B2 (en) | 2002-10-04 | 2008-12-18 | Covidien Lp | Tool assembly for a surgical stapling device |
| US7799026B2 (en) | 2002-11-14 | 2010-09-21 | Covidien Ag | Compressible jaw configuration with bipolar RF output electrodes for soft tissue fusion |
| DE10310995B3 (de) | 2003-03-06 | 2004-09-16 | Aesculap Ag & Co. Kg | Verschlußvorrichtung für einen Stichkanal und Applikatorvorrichtung |
| US6982013B1 (en) | 2003-03-17 | 2006-01-03 | The United States Of America As Represented By The Secretary Of The Navy | Electrostatic charge dissipation compositions including energetic particles |
| WO2004091377A2 (en) | 2003-03-28 | 2004-10-28 | Downey Earl C | Surgical instrument with trigger control |
| US7160299B2 (en) | 2003-05-01 | 2007-01-09 | Sherwood Services Ag | Method of fusing biomaterials with radiofrequency energy |
| US20040254590A1 (en) | 2003-06-16 | 2004-12-16 | Hoffman Gary H. | Method and instrument for the performance of stapled anastamoses |
| US20040260315A1 (en) | 2003-06-17 | 2004-12-23 | Dell Jeffrey R. | Expandable tissue support member and method of forming the support member |
| US7214727B2 (en) | 2003-06-30 | 2007-05-08 | Hyosung Corporation | Solution containing cellulose dissolved in N-methylmorpholine-N-oxide and high tenacity lyocell multifilament using the same |
| US6964363B2 (en) | 2003-07-09 | 2005-11-15 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument having articulation joint support plates for supporting a firing bar |
| AU2004259237B2 (en) | 2003-07-16 | 2009-10-22 | Covidien Lp | Surgical stapling device with tissue tensioner |
| WO2005007208A1 (ja) | 2003-07-17 | 2005-01-27 | Gunze Limited | 自動縫合器用縫合補綴材 |
| US20050059997A1 (en) | 2003-09-17 | 2005-03-17 | Bauman Ann M. | Circular stapler buttress |
| US7547312B2 (en) | 2003-09-17 | 2009-06-16 | Gore Enterprise Holdings, Inc. | Circular stapler buttress |
| US20050070929A1 (en) | 2003-09-30 | 2005-03-31 | Dalessandro David A. | Apparatus and method for attaching a surgical buttress to a stapling apparatus |
| US10105140B2 (en) | 2009-11-20 | 2018-10-23 | Covidien Lp | Surgical console and hand-held surgical device |
| US20050118435A1 (en) | 2003-12-01 | 2005-06-02 | Kimberly-Clark Worldwide, Inc. | Films and methods of forming films having polyorganosiloxane enriched surface layers |
| US20050149073A1 (en) | 2003-12-17 | 2005-07-07 | Arani Djavad T. | Mechanisms and methods used in the anastomosis of biological conduits |
| US20050283256A1 (en) | 2004-02-09 | 2005-12-22 | Codman & Shurtleff, Inc. | Collagen device and method of preparing the same |
| GB2451776B (en) | 2004-02-17 | 2009-04-08 | Cook Biotech Inc | Medical devices and methods useful for applying bolster material |
| US20060008505A1 (en) | 2004-07-08 | 2006-01-12 | Brandon Gerard J | Product |
| US7229690B2 (en) | 2004-07-26 | 2007-06-12 | Massachusetts Institute Of Technology | Microspheres including nanoparticles |
| US7147138B2 (en) | 2004-07-28 | 2006-12-12 | Ethicon Endo-Surgery, Inc. | Surgical stapling instrument having an electroactive polymer actuated buttress deployment mechanism |
| FR2873700B1 (fr) | 2004-07-29 | 2006-11-24 | Centre Nat Rech Scient Cnrse | Procede d'oxydation controlee de polysaccharides |
| US7645874B2 (en) | 2004-08-05 | 2010-01-12 | Xylos Corporation | Cellulose oxidation by nitrogen dioxide in a perfluorinated tertiary amine solvent |
| CA2576441A1 (en) | 2004-08-17 | 2006-03-02 | Tyco Healthcare Group Lp | Stapling support structures |
| US7210810B1 (en) | 2004-09-03 | 2007-05-01 | Pmt Corporation | Surgical headlight assembly |
| US8372094B2 (en) | 2004-10-15 | 2013-02-12 | Covidien Lp | Seal element for anastomosis |
| AU2005295807B2 (en) | 2004-10-18 | 2011-09-01 | Covidien Lp | Annular adhesive structure |
| US7717313B2 (en) | 2004-10-18 | 2010-05-18 | Tyco Healthcare Group Lp | Surgical apparatus and structure for applying sprayable wound treatment material |
| US7845536B2 (en) | 2004-10-18 | 2010-12-07 | Tyco Healthcare Group Lp | Annular adhesive structure |
| US7938307B2 (en) | 2004-10-18 | 2011-05-10 | Tyco Healthcare Group Lp | Support structures and methods of using the same |
| US20080009811A1 (en) | 2004-11-18 | 2008-01-10 | 3M Innovative Properties Company | Non-Skin-Contacting Microneedle Array Applicator |
| DE102004058119A1 (de) | 2004-12-02 | 2006-06-08 | Daimlerchrysler Ag | Poröse SiC-Körper mit Mikrokanälen und Verfahren zu deren Herstellung |
| US7328829B2 (en) | 2004-12-13 | 2008-02-12 | Niti Medical Technologies Ltd. | Palm size surgical stapler for single hand operation |
| US20060173470A1 (en) | 2005-01-31 | 2006-08-03 | Oray B N | Surgical fastener buttress material |
| US7611494B2 (en) | 2005-02-08 | 2009-11-03 | Confluent Surgical, Inc. | Spray for fluent materials |
| US7942890B2 (en) | 2005-03-15 | 2011-05-17 | Tyco Healthcare Group Lp | Anastomosis composite gasket |
| US9364229B2 (en) | 2005-03-15 | 2016-06-14 | Covidien Lp | Circular anastomosis structures |
| US20070203510A1 (en) | 2006-02-28 | 2007-08-30 | Bettuchi Michael J | Annular disk for reduction of anastomotic tension and methods of using the same |
| FR2884134B1 (fr) | 2005-04-07 | 2008-03-28 | Safradim Production Soc Par Ac | Systeme de mise en place de moyens formant renfort d'une suture |
| DE102005017733A1 (de) | 2005-04-15 | 2006-10-19 | Basf Ag | Löslichkeit von Cellulose in ionischen Flüssigkeiten unter Zugabe von Aminbase |
| US20100016888A1 (en) | 2005-05-05 | 2010-01-21 | Allison Calabrese | Surgical Gasket |
| US7655288B2 (en) | 2005-07-29 | 2010-02-02 | Gore Enterprise Holdings, Inc. | Composite self-cohered web materials |
| US7559937B2 (en) * | 2005-08-09 | 2009-07-14 | Towertech Research Group | Surgical fastener apparatus and reinforcing material |
| US7669746B2 (en) | 2005-08-31 | 2010-03-02 | Ethicon Endo-Surgery, Inc. | Staple cartridges for forming staples having differing formed staple heights |
| US7641091B2 (en) | 2005-10-04 | 2010-01-05 | Tyco Healthcare Group Lp | Staple drive assembly |
| JP4707533B2 (ja) | 2005-10-27 | 2011-06-22 | 太陽誘電株式会社 | 圧電薄膜共振器およびフィルタ |
| US9687262B2 (en) | 2005-11-30 | 2017-06-27 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Methods and devices for treating vulnerable plaque |
| US7464849B2 (en) | 2006-01-31 | 2008-12-16 | Ethicon Endo-Surgery, Inc. | Electro-mechanical surgical instrument with closure system and anvil alignment components |
| US9629626B2 (en) | 2006-02-02 | 2017-04-25 | Covidien Lp | Mechanically tuned buttress material to assist with proper formation of surgical element in diseased tissue |
| EP1979018B1 (en) | 2006-02-03 | 2013-08-07 | Tissuemed Limited | Tissue-adhesive materials |
| US7793813B2 (en) | 2006-02-28 | 2010-09-14 | Tyco Healthcare Group Lp | Hub for positioning annular structure on a surgical device |
| US7709631B2 (en) | 2006-03-13 | 2010-05-04 | Xylos Corporation | Oxidized microbial cellulose and use thereof |
| US8252339B2 (en) | 2006-04-11 | 2012-08-28 | Massachusetts Institute Of Technology | Medical treatment applications of swellable and deformable microspheres |
| US8062673B2 (en) | 2006-04-11 | 2011-11-22 | E I Du Pont De Nemours And Company | Process for embolization using swellable and deformable microspheres |
| US20070243227A1 (en) | 2006-04-14 | 2007-10-18 | Michael Gertner | Coatings for surgical staplers |
| US20070246505A1 (en) | 2006-04-24 | 2007-10-25 | Medical Ventures Inc. | Surgical buttress assemblies and methods of uses thereof |
| CA2669438C (en) | 2006-04-24 | 2015-06-16 | Axcelon Biopolymers Corporation | Nanosilver coated bacterial cellulose |
| US7790273B2 (en) | 2006-05-24 | 2010-09-07 | Nellix, Inc. | Material for creating multi-layered films and methods for making the same |
| US7441684B2 (en) | 2006-08-02 | 2008-10-28 | Ethicon Endo-Surgery, Inc. | Pneumatically powered surgical cutting and fastening instrument with audible and visual feedback features |
| US20080078802A1 (en) | 2006-09-29 | 2008-04-03 | Hess Christopher J | Surgical staples and stapling instruments |
| US7845533B2 (en) | 2007-06-22 | 2010-12-07 | Tyco Healthcare Group Lp | Detachable buttress material retention systems for use with a surgical stapling device |
| US8028883B2 (en) | 2006-10-26 | 2011-10-04 | Tyco Healthcare Group Lp | Methods of using shape memory alloys for buttress attachment |
| JP2010508886A (ja) | 2006-11-02 | 2010-03-25 | エスセーアー・ハイジーン・プロダクツ・アーベー | 供給デバイス |
| US7708180B2 (en) | 2006-11-09 | 2010-05-04 | Ethicon Endo-Surgery, Inc. | Surgical fastening device with initiator impregnation of a matrix or buttress to improve adhesive application |
| US8177798B2 (en) | 2006-12-05 | 2012-05-15 | Tyco Healthcare Group Lp | Adhesive coated stent and insertion instrument |
| US8827133B2 (en) | 2007-01-11 | 2014-09-09 | Ethicon Endo-Surgery, Inc. | Surgical stapling device having supports for a flexible drive mechanism |
| US20080169328A1 (en) | 2007-01-11 | 2008-07-17 | Shelton Frederick E | Buttress material for use with a surgical stapler |
| US20080220047A1 (en) | 2007-03-05 | 2008-09-11 | Sawhney Amarpreet S | Low-swelling biocompatible hydrogels |
| US8011555B2 (en) | 2007-03-06 | 2011-09-06 | Tyco Healthcare Group Lp | Surgical stapling apparatus |
| US9888924B2 (en) | 2007-03-06 | 2018-02-13 | Covidien Lp | Wound closure material |
| US8011550B2 (en) | 2009-03-31 | 2011-09-06 | Tyco Healthcare Group Lp | Surgical stapling apparatus |
| CA2680148C (en) | 2007-03-06 | 2015-09-01 | Tyco Healthcare Group Lp | Surgical stapling apparatus |
| US20080216855A1 (en) | 2007-03-07 | 2008-09-11 | Nasca Brian R | Exfoliating apparatus |
| US8590762B2 (en) | 2007-03-15 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Staple cartridge cavity configurations |
| US8038045B2 (en) | 2007-05-25 | 2011-10-18 | Tyco Healthcare Group Lp | Staple buttress retention system |
| BRPI0812404A2 (pt) | 2007-06-12 | 2014-12-02 | Convatec Technologies Inc | Dispositivo de ostomia |
| US7950561B2 (en) | 2007-06-18 | 2011-05-31 | Tyco Healthcare Group Lp | Structure for attachment of buttress material to anvils and cartridges of surgical staplers |
| US7665646B2 (en) | 2007-06-18 | 2010-02-23 | Tyco Healthcare Group Lp | Interlocking buttress material retention system |
| MX2009014115A (es) | 2007-06-25 | 2010-04-21 | Otsuka Pharma Co Ltd | Microesferas que tienen estructura de nucleo/corteza. |
| US8062330B2 (en) | 2007-06-27 | 2011-11-22 | Tyco Healthcare Group Lp | Buttress and surgical stapling apparatus |
| JP5042738B2 (ja) | 2007-07-30 | 2012-10-03 | テルモ株式会社 | 医療用マニピュレータの作業機構及び洗浄方法 |
| US8317790B2 (en) | 2007-09-14 | 2012-11-27 | W. L. Gore & Associates, Inc. | Surgical staple line reinforcements |
| US8470360B2 (en) | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| US8678263B2 (en) | 2007-09-24 | 2014-03-25 | Covidien Lp | Materials delivery system for stapling device |
| ES2426767T3 (es) | 2007-10-08 | 2013-10-25 | Gore Enterprise Holdings, Inc. | Aparato para suministrar un refuerzo de líneas de grapas quirúrgicas |
| US9585657B2 (en) | 2008-02-15 | 2017-03-07 | Ethicon Endo-Surgery, Llc | Actuator for releasing a layer of material from a surgical end effector |
| US20090206125A1 (en) | 2008-02-15 | 2009-08-20 | Ethicon Endo-Surgery, Inc. | Packaging for attaching buttress material to a surgical stapling instrument |
| US8033483B2 (en) | 2008-04-25 | 2011-10-11 | Confluent Surgical Inc. | Silicone spray tip |
| US8408480B2 (en) | 2008-04-25 | 2013-04-02 | Confluent Surgical, Inc. | Self-cleaning spray tip |
| US8091756B2 (en) | 2008-05-09 | 2012-01-10 | Tyco Healthcare Group Lp | Varying tissue compression using take-up component |
| DE112009001239T5 (de) | 2008-05-21 | 2011-04-07 | Cook Biotech, Inc., West Lafayette | Vorrichtungen und Verfahren zum Anbringen von Verstärkungsmaterialien an chirurgischen Befestigungsvorrichtungen |
| US9295757B2 (en) | 2008-06-10 | 2016-03-29 | Cook Biotech Incorporated | Quilted implantable graft |
| US8834465B2 (en) | 2008-07-15 | 2014-09-16 | Immersion Corporation | Modular tool with signal feedback |
| US8409223B2 (en) | 2008-08-29 | 2013-04-02 | Covidien Lp | Endoscopic surgical clip applier with clip retention |
| US8181838B2 (en) | 2008-09-10 | 2012-05-22 | Tyco Healthcare Group Lp | Surgical stapling device |
| US8210453B2 (en) | 2008-09-12 | 2012-07-03 | Confluent Surgical, Inc. | Spray applicator |
| US7886951B2 (en) | 2008-11-24 | 2011-02-15 | Tyco Healthcare Group Lp | Pouch used to deliver medication when ruptured |
| US20100147921A1 (en) | 2008-12-16 | 2010-06-17 | Lee Olson | Surgical Apparatus Including Surgical Buttress |
| WO2010075298A2 (en) | 2008-12-23 | 2010-07-01 | Surmodics Pharmaceuticals, Inc. | Implantable composites and compositions comprising releasable bioactive agents |
| US8016178B2 (en) | 2009-03-31 | 2011-09-13 | Tyco Healthcare Group Lp | Surgical stapling apparatus |
| US7988027B2 (en) | 2009-03-31 | 2011-08-02 | Tyco Healthcare Group Lp | Crimp and release of suture holding buttress material |
| US9486215B2 (en) | 2009-03-31 | 2016-11-08 | Covidien Lp | Surgical stapling apparatus |
| US8365972B2 (en) | 2009-03-31 | 2013-02-05 | Covidien Lp | Surgical stapling apparatus |
| US8348126B2 (en) | 2009-03-31 | 2013-01-08 | Covidien Lp | Crimp and release of suture holding buttress material |
| US7967179B2 (en) | 2009-03-31 | 2011-06-28 | Tyco Healthcare Group Lp | Center cinch and release of buttress material |
| US8418909B2 (en) | 2009-06-02 | 2013-04-16 | Covidien Lp | Surgical instrument and method for performing a resection |
| JP5562583B2 (ja) | 2009-06-24 | 2014-07-30 | カール シュトルツ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディートゲゼルシャフト | 医療用ロボットシステム |
| EP2445417A2 (en) | 2009-06-26 | 2012-05-02 | QuickRing Medical Technologies Ltd. | Surgical stapler |
| US9463260B2 (en) | 2009-06-29 | 2016-10-11 | Covidien Lp | Self-sealing compositions |
| US10383629B2 (en) | 2009-08-10 | 2019-08-20 | Covidien Lp | System and method for preventing reprocessing of a powered surgical instrument |
| CN104307036A (zh) | 2009-10-06 | 2015-01-28 | 明尼苏达大学董事会 | 一种微球形式的栓塞材料及其制备方法与栓塞悬浮液 |
| US20150231409A1 (en) | 2009-10-15 | 2015-08-20 | Covidien Lp | Buttress brachytherapy and integrated staple line markers for margin identification |
| US8157151B2 (en) | 2009-10-15 | 2012-04-17 | Tyco Healthcare Group Lp | Staple line reinforcement for anvil and cartridge |
| US9693772B2 (en) | 2009-10-15 | 2017-07-04 | Covidien Lp | Staple line reinforcement for anvil and cartridge |
| US9610080B2 (en) | 2009-10-15 | 2017-04-04 | Covidien Lp | Staple line reinforcement for anvil and cartridge |
| US10842485B2 (en) | 2009-10-15 | 2020-11-24 | Covidien Lp | Brachytherapy buttress |
| US8322590B2 (en) | 2009-10-28 | 2012-12-04 | Covidien Lp | Surgical stapling instrument |
| US8464925B2 (en) | 2010-05-11 | 2013-06-18 | Ethicon Endo-Surgery, Inc. | Methods and apparatus for delivering tissue treatment compositions to stapled tissue |
| US8646674B2 (en) | 2010-05-11 | 2014-02-11 | Ethicon Endo-Surgery, Inc. | Methods and apparatus for delivering tissue treatment compositions to stapled tissue |
| US20110293690A1 (en) | 2010-05-27 | 2011-12-01 | Tyco Healthcare Group Lp | Biodegradable Polymer Encapsulated Microsphere Particulate Film and Method of Making Thereof |
| JP5033222B2 (ja) | 2010-06-04 | 2012-09-26 | 株式会社アワジテック | 腕ホルダー |
| US9332974B2 (en) | 2010-09-30 | 2016-05-10 | Ethicon Endo-Surgery, Llc | Layered tissue thickness compensator |
| US9241714B2 (en) | 2011-04-29 | 2016-01-26 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator and method for making the same |
| US9204880B2 (en) | 2012-03-28 | 2015-12-08 | Ethicon Endo-Surgery, Inc. | Tissue thickness compensator comprising capsules defining a low pressure environment |
| US9517164B2 (en) | 2010-09-30 | 2016-12-13 | Covidien Lp | Wound dressing with advanced fluid handling |
| US8740038B2 (en) | 2010-09-30 | 2014-06-03 | Ethicon Endo-Surgery, Inc. | Staple cartridge comprising a releasable portion |
| US9480476B2 (en) | 2010-09-30 | 2016-11-01 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator comprising resilient members |
| US8393514B2 (en) | 2010-09-30 | 2013-03-12 | Ethicon Endo-Surgery, Inc. | Selectively orientable implantable fastener cartridge |
| US9320523B2 (en) | 2012-03-28 | 2016-04-26 | Ethicon Endo-Surgery, Llc | Tissue thickness compensator comprising tissue ingrowth features |
| US8348130B2 (en) | 2010-12-10 | 2013-01-08 | Covidien Lp | Surgical apparatus including surgical buttress |
| US8518440B2 (en) | 2010-12-21 | 2013-08-27 | Confluent Surgical, Inc. | Biodegradable osmotic pump implant for drug delivery |
| US9084602B2 (en) | 2011-01-26 | 2015-07-21 | Covidien Lp | Buttress film with hemostatic action for surgical stapling apparatus |
| IT1405423B1 (it) | 2011-02-25 | 2014-01-10 | Thd Spa | Dispositivo per impiantare una protesi in un tessuto |
| US8479968B2 (en) | 2011-03-10 | 2013-07-09 | Covidien Lp | Surgical instrument buttress attachment |
| US8540131B2 (en) | 2011-03-15 | 2013-09-24 | Ethicon Endo-Surgery, Inc. | Surgical staple cartridges with tissue tethers for manipulating divided tissue and methods of using same |
| US8579990B2 (en) | 2011-03-30 | 2013-11-12 | Ethicon, Inc. | Tissue repair devices of rapid therapeutic absorbency |
| US8789737B2 (en) | 2011-04-27 | 2014-07-29 | Covidien Lp | Circular stapler and staple line reinforcement material |
| US9492170B2 (en) | 2011-08-10 | 2016-11-15 | Ethicon Endo-Surgery, Inc. | Device for applying adjunct in endoscopic procedure |
| US9675351B2 (en) | 2011-10-26 | 2017-06-13 | Covidien Lp | Buttress release from surgical stapler by knife pushing |
| US8584920B2 (en) | 2011-11-04 | 2013-11-19 | Covidien Lp | Surgical stapling apparatus including releasable buttress |
| US9351731B2 (en) | 2011-12-14 | 2016-05-31 | Covidien Lp | Surgical stapling apparatus including releasable surgical buttress |
| US9237892B2 (en) | 2011-12-14 | 2016-01-19 | Covidien Lp | Buttress attachment to the cartridge surface |
| US9010608B2 (en) | 2011-12-14 | 2015-04-21 | Covidien Lp | Releasable buttress retention on a surgical stapler |
| US8967448B2 (en) | 2011-12-14 | 2015-03-03 | Covidien Lp | Surgical stapling apparatus including buttress attachment via tabs |
| US9351732B2 (en) | 2011-12-14 | 2016-05-31 | Covidien Lp | Buttress attachment to degradable polymer zones |
| US9113885B2 (en) | 2011-12-14 | 2015-08-25 | Covidien Lp | Buttress assembly for use with surgical stapling device |
| EA027241B1 (ru) | 2011-12-31 | 2017-07-31 | Бейджен, Лтд. | Конденсированные тетра- или пентациклические пиридофталазиноны в качестве ингибиторов parp |
| US9326773B2 (en) | 2012-01-26 | 2016-05-03 | Covidien Lp | Surgical device including buttress material |
| US9010609B2 (en) | 2012-01-26 | 2015-04-21 | Covidien Lp | Circular stapler including buttress |
| US9010612B2 (en) | 2012-01-26 | 2015-04-21 | Covidien Lp | Buttress support design for EEA anvil |
| US9931116B2 (en) | 2012-02-10 | 2018-04-03 | Covidien Lp | Buttress composition |
| US8820606B2 (en) | 2012-02-24 | 2014-09-02 | Covidien Lp | Buttress retention system for linear endostaplers |
| CN104379068B (zh) | 2012-03-28 | 2017-09-22 | 伊西康内外科公司 | 包括组织厚度补偿件的保持器组件 |
| US9572576B2 (en) | 2012-07-18 | 2017-02-21 | Covidien Lp | Surgical apparatus including surgical buttress |
| US20140048580A1 (en) | 2012-08-20 | 2014-02-20 | Covidien Lp | Buttress attachment features for surgical stapling apparatus |
| US9161753B2 (en) | 2012-10-10 | 2015-10-20 | Covidien Lp | Buttress fixation for a circular stapler |
| US20140131418A1 (en) | 2012-11-09 | 2014-05-15 | Covidien Lp | Surgical Stapling Apparatus Including Buttress Attachment |
| US9192384B2 (en) | 2012-11-09 | 2015-11-24 | Covidien Lp | Recessed groove for better suture retention |
| US9681936B2 (en) | 2012-11-30 | 2017-06-20 | Covidien Lp | Multi-layer porous film material |
| US9295466B2 (en) | 2012-11-30 | 2016-03-29 | Covidien Lp | Surgical apparatus including surgical buttress |
| US9402627B2 (en) | 2012-12-13 | 2016-08-02 | Covidien Lp | Folded buttress for use with a surgical apparatus |
| US9204881B2 (en) | 2013-01-11 | 2015-12-08 | Covidien Lp | Buttress retainer for EEA anvil |
| US9433420B2 (en) | 2013-01-23 | 2016-09-06 | Covidien Lp | Surgical apparatus including surgical buttress |
| US9414839B2 (en) | 2013-02-04 | 2016-08-16 | Covidien Lp | Buttress attachment for circular stapling device |
| US9192383B2 (en) | 2013-02-04 | 2015-11-24 | Covidien Lp | Circular stapling device including buttress material |
| US9386984B2 (en) | 2013-02-08 | 2016-07-12 | Ethicon Endo-Surgery, Llc | Staple cartridge comprising a releasable cover |
| US9504470B2 (en) | 2013-02-25 | 2016-11-29 | Covidien Lp | Circular stapling device with buttress |
| US20140239047A1 (en) | 2013-02-28 | 2014-08-28 | Covidien Lp | Adherence concepts for non-woven absorbable felt buttresses |
| US9782173B2 (en) | 2013-03-07 | 2017-10-10 | Covidien Lp | Circular stapling device including buttress release mechanism |
| US9717498B2 (en) | 2013-03-13 | 2017-08-01 | Covidien Lp | Surgical stapling apparatus |
| US9655620B2 (en) | 2013-10-28 | 2017-05-23 | Covidien Lp | Circular surgical stapling device including buttress material |
| US9936950B2 (en) | 2013-11-08 | 2018-04-10 | Ethicon Llc | Hybrid adjunct materials for use in surgical stapling |
| US10561417B2 (en) | 2013-12-09 | 2020-02-18 | Covidien Lp | Adapter assembly for interconnecting electromechanical surgical devices and surgical loading units, and surgical systems thereof |
| US9844378B2 (en) | 2014-04-29 | 2017-12-19 | Covidien Lp | Surgical stapling apparatus and methods of adhering a surgical buttress thereto |
| US9844376B2 (en) | 2014-11-06 | 2017-12-19 | Ethicon Llc | Staple cartridge comprising a releasable adjunct material |
| US10980539B2 (en) | 2015-09-30 | 2021-04-20 | Ethicon Llc | Implantable adjunct comprising bonded layers |
| US10499918B2 (en) | 2015-10-29 | 2019-12-10 | Ethicon Llc | Surgical stapler buttress assembly with features to interact with movable end effector components |
| US10959731B2 (en) | 2016-06-14 | 2021-03-30 | Covidien Lp | Buttress attachment for surgical stapling instrument |
| US11026686B2 (en) | 2016-11-08 | 2021-06-08 | Covidien Lp | Structure for attaching buttress to anvil and/or cartridge of surgical stapling instrument |
| US10716564B2 (en) | 2017-02-17 | 2020-07-21 | Ethicon Llc | Stapling adjunct attachment |
| US10368868B2 (en) | 2017-03-09 | 2019-08-06 | Covidien Lp | Structure for attaching buttress material to anvil and cartridge of surgical stapling instrument |
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2021
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2022
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- 2022-06-16 JP JP2023577786A patent/JP2024524126A/ja active Pending
- 2022-06-16 WO PCT/IB2022/055592 patent/WO2022269419A1/en active Application Filing
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|---|---|
| EP4358865A1 (en) | 2024-05-01 |
| US11672538B2 (en) | 2023-06-13 |
| JP2024524126A (ja) | 2024-07-05 |
| WO2022269419A1 (en) | 2022-12-29 |
| US20220409206A1 (en) | 2022-12-29 |
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