CN117547485A - Production method of nourishing antibacterial hair care composition - Google Patents
Production method of nourishing antibacterial hair care composition Download PDFInfo
- Publication number
- CN117547485A CN117547485A CN202410037838.1A CN202410037838A CN117547485A CN 117547485 A CN117547485 A CN 117547485A CN 202410037838 A CN202410037838 A CN 202410037838A CN 117547485 A CN117547485 A CN 117547485A
- Authority
- CN
- China
- Prior art keywords
- nourishing
- hair care
- care composition
- antibacterial
- titanium dioxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004209 hair Anatomy 0.000 title claims abstract description 82
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000008367 deionised water Substances 0.000 claims abstract description 35
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 35
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 17
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000341 volatile oil Substances 0.000 claims abstract description 12
- 239000004094 surface-active agent Substances 0.000 claims abstract description 11
- 241000220317 Rosa Species 0.000 claims abstract description 8
- 239000003607 modifier Substances 0.000 claims abstract description 8
- 239000003755 preservative agent Substances 0.000 claims abstract description 8
- 230000002335 preservative effect Effects 0.000 claims abstract description 8
- 229960005265 selenium sulfide Drugs 0.000 claims abstract description 8
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 6
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 244000179970 Monarda didyma Species 0.000 claims abstract description 6
- 235000010672 Monarda didyma Nutrition 0.000 claims abstract description 6
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 241000289690 Xenarthra Species 0.000 claims abstract description 6
- 239000004359 castor oil Substances 0.000 claims abstract description 6
- 235000019438 castor oil Nutrition 0.000 claims abstract description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 6
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims abstract description 6
- 239000011976 maleic acid Substances 0.000 claims abstract description 6
- 229940101267 panthenol Drugs 0.000 claims abstract description 6
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 6
- 239000011619 pantothenol Substances 0.000 claims abstract description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 6
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 claims abstract description 3
- 229920002907 Guar gum Polymers 0.000 claims abstract description 3
- 239000000665 guar gum Substances 0.000 claims abstract description 3
- 229960002154 guar gum Drugs 0.000 claims abstract description 3
- 235000010417 guar gum Nutrition 0.000 claims abstract description 3
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 claims abstract 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 120
- 239000004005 microsphere Substances 0.000 claims description 60
- 239000004408 titanium dioxide Substances 0.000 claims description 60
- 238000006243 chemical reaction Methods 0.000 claims description 31
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 30
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 18
- 235000012754 curcumin Nutrition 0.000 claims description 15
- 239000004148 curcumin Substances 0.000 claims description 15
- 229940109262 curcumin Drugs 0.000 claims description 15
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 15
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 14
- 239000000047 product Substances 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 13
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims description 12
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 9
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 9
- 239000007795 chemical reaction product Substances 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 claims description 7
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 7
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 claims description 6
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 6
- 239000004202 carbamide Substances 0.000 claims description 6
- DCKVFVYPWDKYDN-UHFFFAOYSA-L oxygen(2-);titanium(4+);sulfate Chemical compound [O-2].[Ti+4].[O-]S([O-])(=O)=O DCKVFVYPWDKYDN-UHFFFAOYSA-L 0.000 claims description 6
- 229910000348 titanium sulfate Inorganic materials 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000000502 dialysis Methods 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 5
- -1 polytetrafluoroethylene Polymers 0.000 claims description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 3
- 238000000265 homogenisation Methods 0.000 claims description 3
- 239000011159 matrix material Substances 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- HDIFHQMREAYYJW-XGXNLDPDSA-N Glyceryl Ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCC(O)CO HDIFHQMREAYYJW-XGXNLDPDSA-N 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 2
- 240000005385 Jasminum sambac Species 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- 244000178870 Lavandula angustifolia Species 0.000 claims description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 2
- 241000233855 Orchidaceae Species 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 229940071160 cocoate Drugs 0.000 claims description 2
- 239000001102 lavandula vera Substances 0.000 claims description 2
- 235000018219 lavender Nutrition 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims description 2
- 229960003191 potassium methylparaben Drugs 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 108700004121 sarkosyl Proteins 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 2
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 2
- HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 claims description 2
- 208000001840 Dandruff Diseases 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 13
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- JNMWHTHYDQTDQZ-UHFFFAOYSA-N selenium sulfide Chemical compound S=[Se]=S JNMWHTHYDQTDQZ-UHFFFAOYSA-N 0.000 description 6
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- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 4
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- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 3
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
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- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
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- 229940011671 vitamin b6 Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
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Abstract
The invention relates to the technical field of daily chemical products, in particular to a production method of a nourishing, antibacterial and hair care composition; the nourishing antibacterial hair care composition comprises the following raw materials in percentage by weight: selenium sulfide 0.5-0.8%, panthenol 0.3-0.6%, bergamot essential oil 2.0-4.0%, rose essential oil 1.5-3.0%, o-hydroxybenzoic acid 0.2-0.5%, disodium edentate 0.08-0.25%, guar gum hydroxypropyl trimethyl ammonium chloride 1.0-1.8%, surfactant 12-16%, maleic acid modified castor oil 1.5-3.5%, functional auxiliary agent 0.8-1.5%, preservative 0.5-0.8%, acid-base modifier 0.2-0.4%, essence 0.25-0.4% and deionized water for the rest; the hair care composition produced by the invention has excellent treatment effects on aspects of removing dandruff, resisting fungi, resisting scalp seborrheic dermatitis and the like; furthermore, the hair conditioner also has good nourishing effect on hair, achieves the positive effects of hair care and hair nourishing, and effectively improves the health condition of hair.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to a production method of a nourishing, antibacterial and hair care composition.
Background
Dandruff is mainly caused by the dandruff spore bacteria. Most people have dandruff spore bacteria on the scalp, and some do not produce symptoms. The dandruff spore bacteria are affected by external and internal factors, proliferate greatly, and destroy the normal metabolism of scalp, which is the main reason for the production of dandruff. Deficiency of vitamin B12, vitamin F, vitamin B6 in the body can also cause excessive dandruff.
Dandruff is a general skin pollution, i.e. the continuous exfoliating surface of the stratum corneum of the epidermis, also as a result of metabolism, and is divided into physiological and pathological dandruff. Physiological dandruff is usually dry dandruff, and small phosphine scraps in bran shape and off-white color are scattered among hairs. The other type is oily dander, which is a greasy, slimy feel on the scalp and hair, with crusts of varying thickness, which is especially common to young children. Pathological dandruff refers to inflammation of the scalp caused by bacterial infection, fungal infection, or other physical and chemical injury. It is generally characterized by excessive dandruff and blocked pores, which can cause the hair to be in a weakened state, and the hair can be easily proliferated by bacteria, so that the skin is stimulated to produce itching.
At present, although the commercial hair care composition can have certain cleaning and nourishing effects on the hair of a user, the hair care composition has relatively poor nourishing and antibacterial properties, and has a non-ideal treatment effect on dandruff and scalp seborrheic dermatitis. Accordingly, the present application provides a method for producing a nourishing, antibacterial and hair care composition, which solves the technical problems set forth above.
Disclosure of Invention
The invention aims to provide a production method of a nourishing and antibacterial hair care composition, and the hair care composition produced by the production method has excellent antibacterial performance and has excellent treatment effects on aspects of removing dandruff, resisting fungi, resisting scalp seborrheic dermatitis and the like. Furthermore, the hair conditioner also has good nourishing effect on hair, achieves the positive effects of hair care and hair nourishing, and effectively improves the health condition of hair.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a nourishing and antibacterial hair care composition comprises the following raw materials in percentage by weight: selenium sulfide 0.5-0.8%, panthenol 0.3-0.6%, bergamot essential oil 2.0-4.0%, rose essential oil 1.5-3.0%, o-hydroxybenzoic acid 0.2-0.5%, disodium edentate 0.08-0.25%, guar gum hydroxypropyl trimethyl ammonium chloride 1.0-1.8%, surfactant 12-16%, maleic acid modified castor oil 1.5-3.5%, functional auxiliary agent 0.8-1.5%, preservative 0.5-0.8%, acid-base modifier 0.2-0.4%, essence 0.25-0.4% and deionized water for the rest;
the functional auxiliary agent takes titanium dioxide porous microspheres as a matrix material, is pretreated by a silane coupling agent, and then is grafted with histidine and curcumin through chemical reaction.
Further, the surfactant is selected from one of sodium lauroyl sarcosinate, glycerol monoricinoleate, glycine cocoate, sodium methyl cocoamidopropionate and dodecyl betaine.
Further, the preservative is any one of potassium sorbate, methylparaben and methylisothiazolinone.
Further, the essence is selected from any one of milk essence, lavender essence, orchid essence, violet essence, rose essence and jasmine essence.
Further, the preparation method of the functional auxiliary agent comprises the following steps: adding pretreated titanium dioxide porous microspheres into ethanol water solution with the volume concentration of 60-70% according to the solid-to-liquid ratio of 0.01-0.02 g/mL, adding curcumin with the mass of 3-5% of the ethanol water solution, sequentially adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, 0.03-0.05 times of N-hydroxysuccinimide and 2-3 times of histidine with the mass of 0.03-0.04 times of the pretreated titanium dioxide porous microspheres after ultrasonic dispersion uniformly, mixing and stirring uniformly, heating the obtained mixed components to 30-40 ℃, and carrying out heat preservation reaction for 30-40 hours at the temperature; and after the reaction is finished, sequentially carrying out dialysis and drying treatment on the obtained product components, and finally obtaining the functional auxiliary agent.
Further, the preparation method of the pretreated titanium dioxide porous microsphere comprises the following steps: adding titanium dioxide porous microspheres into deionized water at 60-75 ℃ according to the solid-to-liquid ratio of 0.01-0.03 g/mL, performing ultrasonic dispersion for 20-30 min, and sequentially adding 3-aminopropyl triethoxysilane with the mass being 2-5 times of that of the titanium dioxide porous microspheres and ammonia water with the volume being 1.5-2.5 times of that of the 3-aminopropyl triethoxysilane and the concentration being 20-25%; uniformly mixing and dispersing, and stirring at 70-85 ℃ for reaction for 8-12 h; and after the reaction is finished, naturally cooling the obtained product components to room temperature, and sequentially carrying out centrifugal filtration, deionized water washing and vacuum drying treatment to obtain the pretreated titanium dioxide porous microspheres.
Further, the preparation method of the titanium dioxide porous microsphere comprises the following steps: titanium sulfate, urea, disodium ethylenediamine tetraacetate and ammonium fluoride are mixed according to a mole ratio of 1: 4-8: 1-2: 2-4, putting the mixture into a polytetrafluoroethylene autoclave liner, then adding deionized water until the filling degree of the liner is 30-70%, and stirring for 2-4 hours to obtain white emulsion; placing the autoclave into a blast drying oven, setting the reaction temperature to be 180 ℃, and preserving the heat for 3-15 h; after the reaction is finished, naturally cooling the autoclave, taking out a reaction product, and repeatedly washing with deionized water and absolute ethyl alcohol until an aqueous solution is neutral; and finally, putting the product into an oven to be dried for 2-10 hours at the temperature of 70 ℃ to obtain the titanium dioxide porous microspheres.
Furthermore, the acid-base modifier is any one of citric acid, sodium citrate and arginine.
A method for producing a nourishing, antibacterial and hair care composition, comprising the steps of:
firstly, accurately weighing all raw materials required by preparing a nourishing, antibacterial and hair care composition, pouring deionized water into mixing equipment, and controlling the water temperature to be 75-85 ℃ by adopting a water bath heating mode;
step two, adding a surfactant into the deionized water, mechanically stirring for 20-30 min, and preserving the obtained first mixed solution for later use;
adding the rest raw materials except the essence and the citric acid into the first mixed solution, mechanically mixing and stirring for 30-40 min, adding the essence and the citric acid into the first mixed solution, transferring the obtained mixed material into homogenizing equipment, and homogenizing for 20-30 min at a speed of 3000-5000 rpm;
and fourthly, naturally cooling the mixed materials in the homogenizing equipment to room temperature after homogenization is completed, and then sequentially packaging the mixed materials by a filling machine to obtain the nourishing, antibacterial and hair care composition.
Compared with the prior art, the invention has the beneficial effects that:
in the invention, titanium sulfate, urea, disodium ethylenediamine tetraacetate, ammonium fluoride and the like are used as raw materials, and spherical nano titanium dioxide with a porous structure, namely titanium dioxide porous microspheres, are prepared by adopting a hydrothermal synthesis method. And then dispersing the titanium dioxide porous microspheres in toluene, adding 3-aminopropyl triethoxysilane into the titanium dioxide porous microspheres to enable the titanium dioxide porous microspheres to react with related groups on the surfaces of the titanium dioxide porous microspheres, and finally connecting the 3-aminopropyl triethoxysilane into the surfaces of the titanium dioxide porous microspheres and the pore structures in the titanium dioxide porous microspheres through chemical bonds, so that the pretreatment of the pretreated titanium dioxide porous microspheres is realized. Finally, putting the pretreated titanium dioxide porous microspheres into ethanol water solution, and sequentially adding curcumin, 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and histidine into the solution; under the action of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, histidine and related groups on the surface of the pretreated titanium dioxide porous microsphere are subjected to chemical reaction, so that the antibacterial property of the pretreated titanium dioxide porous microsphere is effectively improved. In addition, ultrasonic dispersion enables curcumin to be uniformly dispersed on the surface of the pretreated titanium dioxide porous microsphere and in the pore structure of the pretreated titanium dioxide porous microsphere. Finally, curcumin and histidine are effectively grafted on the surface of the pretreated titanium dioxide porous microsphere and the pore structure in the surface of the pretreated titanium dioxide porous microsphere through chemical reaction, and the curcumin and the histidine are mutually cooperated and mutually matched, so that the prepared functional auxiliary agent has a remarkable antibacterial effect.
In conclusion, the functional auxiliary agent and the selenium disulfide are mutually cooperated and matched, so that the antibacterial performance of the hair care composition is effectively improved, and the hair care composition has excellent treatment effects on aspects of removing dandruff, resisting fungi, resisting scalp seborrheic dermatitis and the like. Furthermore, the hair care composition produced by the invention has good nourishing effect on hair, achieves the positive effects of hair care and hair nourishing, and effectively improves the health condition of hair.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is an infrared spectrum of functional additives and curcumin in the present invention.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A nourishing and antibacterial hair care composition comprises the following raw materials in percentage by weight: selenium sulfide 0.5%, panthenol 0.3%, bergamot essential oil 2.0%, rose essential oil 1.5%, o-hydroxybenzoic acid 0.2%, disodium edentate 0.08%, guar hydroxypropyl trimonium chloride 1.0%, surfactant 12%, maleic acid modified castor oil 1.5%, functional auxiliary agent 0.8%, preservative 0.5%, acid-base modifier 0.2%, essence 0.25%, and deionized water the rest;
the functional auxiliary agent takes titanium dioxide porous microspheres as a matrix material, is pretreated by a silane coupling agent, and then is grafted with histidine and curcumin through chemical reaction.
The preparation method of the functional auxiliary agent comprises the following steps: adding pretreated titanium dioxide porous microspheres into ethanol water solution with volume concentration of 60% according to solid-to-liquid ratio of 0.01g/mL, then adding curcumin with mass of 3% of the ethanol water solution, after ultrasonic dispersion uniformly, sequentially adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, 0.03 times of N-hydroxysuccinimide and 2 times of histidine with mass of 0.03 times of the pretreated titanium dioxide porous microspheres, mixing and stirring uniformly, heating the temperature of the obtained mixed components to 30 ℃, and carrying out heat preservation reaction for 30 hours at the temperature; and after the reaction is finished, sequentially carrying out dialysis and drying treatment on the obtained product components, and finally obtaining the functional auxiliary agent.
The preparation method of the pretreated titanium dioxide porous microsphere comprises the following steps: adding titanium dioxide porous microspheres into deionized water at 60 ℃ according to the solid-to-liquid ratio of 0.01g/mL, and sequentially adding 3-aminopropyl triethoxysilane with the mass being 2 times of the titanium dioxide porous microspheres and ammonia water with the volume being 1.5 times of the 3-aminopropyl triethoxysilane and the concentration being 20% into the deionized water after ultrasonic dispersion for 20min; stirring and reacting for 8 hours at the temperature of 70 ℃ after uniformly mixing and dispersing; and after the reaction is finished, naturally cooling the obtained product components to room temperature, and sequentially carrying out centrifugal filtration, deionized water washing and vacuum drying treatment to obtain the pretreated titanium dioxide porous microspheres.
The preparation method of the titanium dioxide porous microsphere comprises the following steps: according to the following steps of 1:5:1.5:2, putting titanium sulfate, urea, EDTA and ammonium fluoride into a polytetrafluoroethylene autoclave liner according to a molar ratio, then adding deionized water until the filling degree of the liner is 40%, mixing and stirring for 2 hours to obtain a white emulsion; placing the autoclave into a blast drying oven, and reacting for 6 hours at the temperature of 180 ℃; and after the reaction is finished, naturally cooling the autoclave to room temperature, taking out a reaction product, repeatedly washing with deionized water and absolute ethyl alcohol until an aqueous solution is neutral, and finally drying the reaction product at 65 ℃ for 8 hours to obtain the titanium dioxide porous microspheres, thus obtaining the titanium dioxide porous microspheres.
A method for producing a nourishing, antibacterial and hair care composition, comprising the steps of:
firstly, accurately weighing all raw materials required by preparing a nourishing, antibacterial and hair care composition, pouring deionized water into mixing equipment, and controlling the water temperature to 75 ℃ by adopting a water bath heating mode;
step two, adding a surfactant into deionized water, mechanically stirring for 20min, and preserving the obtained first mixed solution for later use;
adding the rest raw materials except the essence and the citric acid into the first mixed solution, mechanically mixing and stirring for 30min, adding the essence and the citric acid into the first mixed solution, transferring the obtained mixed material into homogenizing equipment, and homogenizing for 20min at a speed of 3000 rpm;
and fourthly, naturally cooling the mixed materials in the homogenizing equipment to room temperature after homogenization is completed, and then sequentially packaging the mixed materials by a filling machine to obtain the nourishing, antibacterial and hair care composition.
Example 2
The hair care composition provided in this example was produced in the same manner as in example 1, except that: the specific raw material composition of the hair care composition and the specific preparation method of the functional auxiliary agent in this embodiment are different. The specific raw material composition of the hair care composition and the specific preparation method of the functional auxiliary agent in the embodiment are as follows:
a nourishing and antibacterial hair care composition comprises the following raw materials in percentage by weight: selenium sulfide 0.6%, panthenol 0.5%, bergamot essential oil 3.0%, rose essential oil 2.5%, o-hydroxybenzoic acid 0.3%, disodium edentate 0.15%, guar hydroxypropyl trimonium chloride 1.5%, surfactant 14%, maleic acid modified castor oil 2.5%, functional auxiliary agent 1.2%, preservative 0.6%, acid-base modifier 0.3%, essence 0.3% and deionized water the rest.
The preparation method of the functional auxiliary agent comprises the following steps: adding pretreated titanium dioxide porous microspheres into ethanol water solution with the volume concentration of 65% according to the solid-to-liquid ratio of 0.015g/mL, then adding curcumin with the mass of 4% of the ethanol water solution, uniformly dispersing by ultrasonic waves, sequentially adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, 0.04 times of N-hydroxysuccinimide and 2.5 times of histidine with the mass of 0.03-0.04 times of the pretreated titanium dioxide porous microspheres, uniformly mixing and stirring, heating the temperature of the obtained mixed components to 35 ℃, and carrying out heat preservation reaction for 35 hours at the temperature; and after the reaction is finished, sequentially carrying out dialysis and drying treatment on the obtained product components, and finally obtaining the functional auxiliary agent.
The preparation method of the pretreated titanium dioxide porous microsphere comprises the following steps: putting the titanium dioxide porous microspheres into deionized water at 70 ℃ according to the solid-to-liquid ratio of 0.02g/mL, and sequentially adding 3-aminopropyl triethoxysilane with the mass being 4 times of that of the titanium dioxide porous microspheres and ammonia water with the volume being 2.0 times of that of the 3-aminopropyl triethoxysilane and the concentration being 25% into the deionized water after ultrasonic dispersion for 25 min; stirring and reacting for 10 hours at the temperature of 80 ℃ after uniformly mixing and dispersing; and after the reaction is finished, naturally cooling the obtained product components to room temperature, and sequentially carrying out centrifugal filtration, deionized water washing and vacuum drying treatment to obtain the pretreated titanium dioxide porous microspheres.
The preparation method of the titanium dioxide porous microsphere comprises the following steps: titanium sulfate, urea, disodium ethylenediamine tetraacetate and ammonium fluoride are mixed according to a mole ratio of 1:6:1.5:3, placing the mixture into a polytetrafluoroethylene autoclave liner, then adding deionized water until the filling degree of the liner is 50%, and stirring for 3 hours to obtain a white emulsion; placing the autoclave into a blast drying oven, setting the reaction temperature to 180 ℃, and preserving the heat for 10 hours; after the reaction is finished, naturally cooling the autoclave, taking out a reaction product, and repeatedly washing with deionized water and absolute ethyl alcohol until an aqueous solution is neutral; and finally, putting the product into an oven to be dried for 6 hours at 70 ℃ to obtain the titanium dioxide porous microspheres.
Example 3
The hair care composition provided in this example was produced in the same manner as in example 1, except that: the specific raw material composition of the hair care composition and the specific preparation method of the functional auxiliary agent in this embodiment are different. The specific raw material composition of the hair care composition and the specific preparation method of the functional auxiliary agent in the embodiment are as follows:
a nourishing and antibacterial hair care composition comprises the following raw materials in percentage by weight: selenium sulfide 0.8%, panthenol 0.6%, bergamot essential oil 4.0%, rose essential oil 3.0%, o-hydroxybenzoic acid 0.5%, disodium edentate 0.25%, guar hydroxypropyl trimonium chloride 1.8%, surfactant 16%, maleic acid modified castor oil 3.5%, functional auxiliary agent 1.5%, preservative 0.8%, acid-base modifier 0.4%, essence 0.4% and deionized water the rest.
The preparation method of the functional auxiliary agent comprises the following steps: adding pretreated titanium dioxide porous microspheres into ethanol water solution with the volume concentration of 70% according to the solid-to-liquid ratio of 0.02g/mL, then adding curcumin with the mass of 5% of the ethanol water solution, uniformly dispersing by ultrasonic waves, sequentially adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, 0.05 times N-hydroxysuccinimide and 3 times histidine with the mass of 0.04 times that of the pretreated titanium dioxide porous microspheres, uniformly mixing and stirring, heating the temperature of the obtained mixed components to 40 ℃, and carrying out heat preservation reaction for 40 hours at the temperature; and after the reaction is finished, sequentially carrying out dialysis and drying treatment on the obtained product components, and finally obtaining the functional auxiliary agent.
The preparation method of the pretreated titanium dioxide porous microsphere comprises the following steps: putting the titanium dioxide porous microspheres into deionized water at 75 ℃ according to the solid-to-liquid ratio of 0.03g/mL, and sequentially adding 3-aminopropyl triethoxysilane with the mass being 5 times of that of the titanium dioxide porous microspheres and ammonia water with the volume being 2.5 times of that of the 3-aminopropyl triethoxysilane and the concentration being 25% into the deionized water after ultrasonic dispersion for 30min; uniformly mixing and dispersing, and stirring at the temperature of 85 ℃ for reaction for 12 hours; and after the reaction is finished, naturally cooling the obtained product components to room temperature, and sequentially carrying out centrifugal filtration, deionized water washing and vacuum drying treatment to obtain the pretreated titanium dioxide porous microspheres.
The preparation method of the titanium dioxide porous microsphere comprises the following steps: titanium sulfate, urea, disodium ethylenediamine tetraacetate and ammonium fluoride are mixed according to a mole ratio of 1:8:2:4, placing the mixture into a polytetrafluoroethylene autoclave liner, then adding deionized water until the filling degree of the liner is 70%, and stirring for 4 hours to obtain a white emulsion; placing the autoclave into a blast drying oven, setting the reaction temperature to be 180 ℃, and preserving the heat for 15 hours; after the reaction is finished, naturally cooling the autoclave, taking out a reaction product, and repeatedly washing with deionized water and absolute ethyl alcohol until an aqueous solution is neutral; and finally, putting the product into an oven to be dried for 10 hours at 70 ℃ to obtain the titanium dioxide porous microspheres.
Comparative example 1: the difference from example 1 is that: in the embodiment, the functional auxiliary agent is replaced by equivalent titanium dioxide porous microspheres;
comparative example 2: the difference from example 1 is that: equal amount of histidine is adopted to replace curcumin;
comparative example 3: the difference from example 1 is that: equal amounts of curcumin were used instead of histidine.
Performance test: the hair care composition samples provided in examples 1 to 3 and comparative examples 1 to 3 are labeled as examples 1 to 3 and comparative examples 1 to 3, respectively; and the following tests were performed on the relevant properties of the hair care compositions provided in 1 to 3 and comparative examples 1 to 3, respectively:
1. and (3) testing anti-dandruff and hair-moistening performance:
300 volunteers with dandruff were divided into 6 groups of 50 persons each and labeled as examples 1 to 3 and comparative examples 1 to 3, respectively. Then, the volunteers of examples 1 to 3 and comparative examples 1 to 3 were tested on the samples of the nourishing and antibacterial hair care compositions provided in examples 1 to 3 and comparative examples 1 to 3, respectively, which were matched with the groups, and were used 2 times per week, the smoothness of the hair of the volunteers of the different groups was determined by the friction coefficient, 10 hairs were randomly selected from each group, fixed on a slide glass, and then combed and slid with a detector from the root to the tip of the hair, the average friction coefficient was measured, the number of people of each grade was recorded, and the obtained test results were recorded in the following table 1: simultaneously evaluating safety and anti-dandruff efficacy through the use experience of volunteers; the test results obtained are recorded in table 2 below:
wherein, the anti-dandruff efficacy criteria are as follows:
1. is very effective: the anti-dandruff effect is very good, the foam is fine and smooth and full, and the hair is fresh and not tight after washing;
2. the method is effective: the hair conditioner has a certain anti-dandruff effect, foam is easy to rinse, and hair is not dried after washing;
3. invalidation: no change is caused before and after the use.
2. Anti-inflammatory performance test:
300 volunteers with scalp seborrheic dermatitis were divided into 6 groups of 50 persons each, and labeled as examples 1 to 3 and comparative examples 1 to 3, respectively. The volunteers of examples 1 to 3 and comparative examples 1 to 3 were then tested on the samples of the nourishing, antibacterial and hair care compositions provided in examples 1 to 3 and comparative examples 1 to 3, respectively, which were matched to the groups, and were used 2 times per week, and one month later, each volunteer was revisited and the treatment of scalp seborrheic dermatitis was recorded, and the test results obtained were recorded in table 3:
table 1 shows the hair conditioning effects of each group of nourishing, antibacterial and hair care compositions
Table 2 shows the anti-dandruff effect and the safety test results of the nourishing, antibacterial and hair care compositions of each group
Table 3 shows the therapeutic effects of each group of nourishing, antibacterial hair care compositions on the symptoms of seborrheic dermatitis
As can be seen by comparing and analyzing the related data in tables 1 to 3, the functional auxiliary agent and selenium disulfide are mutually cooperated and matched, so that the antibacterial performance of the produced hair care composition is effectively improved, and the hair care composition has excellent treatment effects in aspects of removing dandruff, resisting fungi, resisting scalp seborrheic dermatitis and the like; furthermore, the produced hair care composition has good nourishing effect on hair, achieves the positive effects of hair care and hair nourishing, and effectively improves the health condition of hair. Therefore, the nourishing antibacterial hair care composition and the production method thereof provided by the invention have wider market prospect and are more suitable for popularization.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.
Claims (9)
1. A nourishing, antibacterial and hair care composition, characterized in that: the material consists of the following raw materials in percentage by weight: selenium sulfide 0.5-0.8%, panthenol 0.3-0.6%, bergamot essential oil 2.0-4.0%, rose essential oil 1.5-3.0%, o-hydroxybenzoic acid 0.2-0.5%, disodium edentate 0.08-0.25%, guar gum hydroxypropyl trimethyl ammonium chloride 1.0-1.8%, surfactant 12-16%, maleic acid modified castor oil 1.5-3.5%, functional auxiliary agent 0.8-1.5%, preservative 0.5-0.8%, acid-base modifier 0.2-0.4%, essence 0.25-0.4% and deionized water for the rest;
the functional auxiliary agent takes titanium dioxide porous microspheres as a matrix material, is pretreated by a silane coupling agent, and then is grafted with histidine and curcumin through chemical reaction.
2. A nourishing, antibacterial and hair care composition according to claim 1, characterized in that: the surfactant is selected from one of sodium lauroyl sarcosinate, glycerol monoricinoleate, glycine cocoate, sodium methyl cocoamidopropionate and dodecyl betaine.
3. A nourishing, antibacterial and hair care composition according to claim 1, characterized in that: the preservative is any one of potassium sorbate, methylparaben and methylisothiazolinone.
4. A nourishing, antibacterial and hair care composition according to claim 1, characterized in that: the essence is selected from one of milk essence, lavender essence, orchid essence, violet essence, rose essence and jasmine essence.
5. The nourishing and antibacterial hair care composition according to claim 1, wherein the functional auxiliary agent is prepared by the following steps: adding pretreated titanium dioxide porous microspheres into ethanol water solution with the volume concentration of 60-70% according to the solid-to-liquid ratio of 0.01-0.02 g/mL, adding curcumin with the mass of 3-5% of the ethanol water solution, sequentially adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride, 0.03-0.05 times of N-hydroxysuccinimide and 2-3 times of histidine with the mass of 0.03-0.04 times of the pretreated titanium dioxide porous microspheres after ultrasonic dispersion uniformly, mixing and stirring uniformly, heating the obtained mixed components to 30-40 ℃, and carrying out heat preservation reaction for 30-40 hours at the temperature; and after the reaction is finished, sequentially carrying out dialysis and drying treatment on the obtained product components, and finally obtaining the functional auxiliary agent.
6. The nourishing and antibacterial hair care composition according to claim 5, wherein the preparation method of the pretreated titanium dioxide porous microspheres is as follows: adding titanium dioxide porous microspheres into deionized water at 60-75 ℃ according to the solid-to-liquid ratio of 0.01-0.03 g/mL, performing ultrasonic dispersion for 20-30 min, and sequentially adding 3-aminopropyl triethoxysilane with the mass being 2-5 times of that of the titanium dioxide porous microspheres and ammonia water with the volume being 1.5-2.5 times of that of the 3-aminopropyl triethoxysilane and the concentration being 20-25%; uniformly mixing and dispersing, and stirring at 70-85 ℃ for reaction for 8-12 h; and after the reaction is finished, naturally cooling the obtained product components to room temperature, and sequentially carrying out centrifugal filtration, deionized water washing and vacuum drying treatment to obtain the pretreated titanium dioxide porous microspheres.
7. The nourishing and antibacterial hair care composition according to claim 6, wherein the preparation method of the titanium dioxide porous microspheres is as follows: according to the following steps of 1: 5-8: 1.5 to 2.0: 2-4, putting titanium sulfate, urea, EDTA and ammonium fluoride into a polytetrafluoroethylene autoclave liner, then adding deionized water until the filling degree of the liner is 40-60%, mixing and stirring for 2-5 hours to obtain white emulsion; placing the autoclave into a blast drying oven, and reacting for 6-15 h at 180 ℃; and after the reaction is finished, naturally cooling the autoclave to room temperature, taking out a reaction product, repeatedly washing the reaction product with deionized water and absolute ethyl alcohol until an aqueous solution is neutral, and finally drying the reaction product at 65-75 ℃ for 5-8 hours to obtain the titanium dioxide porous microspheres.
8. A nourishing, antibacterial and hair care composition according to claim 1, characterized in that: the acid-base modifier is any one of citric acid, sodium citrate and arginine.
9. A method for producing a nourishing, antibacterial and hair care composition according to any one of claims 1 to 8, comprising the steps of:
firstly, accurately weighing all raw materials required by preparing a nourishing, antibacterial and hair care composition, pouring deionized water into mixing equipment, and controlling the water temperature to be 75-85 ℃ by adopting a water bath heating mode;
step two, adding a surfactant into the deionized water, mechanically stirring for 20-30 min, and preserving the obtained first mixed solution for later use;
adding the rest raw materials except the essence and the citric acid into the first mixed solution, mechanically mixing and stirring for 30-40 min, adding the essence and the citric acid into the first mixed solution, transferring the obtained mixed material into homogenizing equipment, and homogenizing for 20-30 min at a speed of 3000-5000 rpm;
and fourthly, naturally cooling the mixed materials in the homogenizing equipment to room temperature after homogenization is completed, and then sequentially packaging the mixed materials by a filling machine to obtain the nourishing, antibacterial and hair care composition.
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| CN103771506A (en) * | 2013-12-24 | 2014-05-07 | 中国科学院合肥物质科学研究院 | Micro/nano hierarchical titanium dioxide microspheres as well as preparation method and application thereof |
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| CN113416535A (en) * | 2021-07-20 | 2021-09-21 | 安徽大学 | Fluorescent carbon quantum dot @ silicon dioxide microsphere and preparation method and application thereof |
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| CN116435705A (en) * | 2023-06-09 | 2023-07-14 | 苏州精控能源科技有限公司 | High-thermal-stability flame-retardant lithium battery diaphragm, preparation method thereof and lithium battery |
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| CN103771506A (en) * | 2013-12-24 | 2014-05-07 | 中国科学院合肥物质科学研究院 | Micro/nano hierarchical titanium dioxide microspheres as well as preparation method and application thereof |
| CN104922675A (en) * | 2015-05-25 | 2015-09-23 | 东华大学 | Preparation method of graphene oxide composite material mediated by carboxymethyl chitosan and modified by hyaluronic acid |
| CN113416535A (en) * | 2021-07-20 | 2021-09-21 | 安徽大学 | Fluorescent carbon quantum dot @ silicon dioxide microsphere and preparation method and application thereof |
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