CN117545765A - 嵌合抗原受体t细胞 - Google Patents
嵌合抗原受体t细胞 Download PDFInfo
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- CN117545765A CN117545765A CN202280044126.1A CN202280044126A CN117545765A CN 117545765 A CN117545765 A CN 117545765A CN 202280044126 A CN202280044126 A CN 202280044126A CN 117545765 A CN117545765 A CN 117545765A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
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- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/21—Transmembrane domain
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- A—HUMAN NECESSITIES
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- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C07K2319/00—Fusion polypeptide
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB2105684.1A GB202105684D0 (en) | 2021-04-21 | 2021-04-21 | Chimeric antigen receptor (CAR)-T cells |
| GB2105684.1 | 2021-04-21 | ||
| PCT/GB2022/051003 WO2022223975A1 (en) | 2021-04-21 | 2022-04-21 | Chimeric antigen receptor (car)-t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117545765A true CN117545765A (zh) | 2024-02-09 |
Family
ID=76377669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280044126.1A Pending CN117545765A (zh) | 2021-04-21 | 2022-04-21 | 嵌合抗原受体t细胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240181056A1 (https=) |
| EP (1) | EP4326759A1 (https=) |
| JP (1) | JP2024514355A (https=) |
| KR (1) | KR20240000541A (https=) |
| CN (1) | CN117545765A (https=) |
| AU (1) | AU2022260700A1 (https=) |
| CA (1) | CA3215838A1 (https=) |
| GB (1) | GB202105684D0 (https=) |
| WO (1) | WO2022223975A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119997968A (zh) * | 2022-08-23 | 2025-05-13 | 帝国理工学院创新有限公司 | TCR β链可变区的嵌合抗原受体(CAR) |
| CN116058334B (zh) * | 2022-11-21 | 2023-08-08 | 中国人民解放军军事科学院军事医学研究院 | 一种可视化gvhd动物模型的构建方法及其应用 |
| US20250290039A1 (en) * | 2023-07-10 | 2025-09-18 | Pluri Biotech Ltd. | Genetically engineered placental mucosalassociated invariant t (mait) cells and uses thereof |
| WO2025208050A2 (en) * | 2024-03-28 | 2025-10-02 | The Regents Of The University Of California | Engineered mucosal-associated invariant t (mait) cells and methods of making and using thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10245262B2 (en) | 2014-04-01 | 2019-04-02 | The University Of Queensland | Immunological reagents and uses therefor |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| JP2017529851A (ja) * | 2014-09-26 | 2017-10-12 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 養子免疫療法のためのグリピカン−3特異的キメラ抗原レセプター |
| JP7237449B2 (ja) * | 2015-02-27 | 2023-03-13 | アイセル・ジーン・セラピューティクス・エルエルシー | 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法 |
| CN109897114B (zh) * | 2017-12-08 | 2022-08-02 | 亘喜生物科技(上海)有限公司 | 具有自杀基因开关的靶向cd47的工程化免疫细胞 |
| EP4219688B1 (en) * | 2018-12-19 | 2026-01-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mucosal-associated invariant t (mait) cells expressing chimeric antigen receptors |
| AU2020275049A1 (en) * | 2019-05-16 | 2022-01-06 | Nanjing Legend Biotech Co., Ltd. | Engineered immune cells comprsing a recognition molecule |
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| CA3215838A1 (en) | 2022-10-27 |
| GB202105684D0 (en) | 2021-06-02 |
| AU2022260700A9 (en) | 2023-11-16 |
| EP4326759A1 (en) | 2024-02-28 |
| WO2022223975A1 (en) | 2022-10-27 |
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| KR20240000541A (ko) | 2024-01-02 |
| AU2022260700A1 (en) | 2023-11-09 |
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