CN117357415B

CN117357415B - Acne-removing composition and preparation method and application thereof

Info

Publication number: CN117357415B
Application number: CN202311275118.0A
Authority: CN
Inventors: 贺青; 刘露; 钟小超
Original assignee: Baocui Biotechnology Co ltd
Current assignee: Baocui Biotechnology Co ltd
Priority date: 2023-09-28
Filing date: 2023-09-28
Publication date: 2024-05-14
Anticipated expiration: 2043-09-28
Also published as: CN117357415A

Abstract

The present disclosure provides an acne-removing composition, a preparation method and an application thereof, and belongs to the technical field of cosmetics. The acne-removing composition disclosed by the invention comprises the following components in parts by weight: 1-5 parts of allantoin, 1-5 parts of trehalose, 20-35 parts of dipropylene glycol, 5-10 parts of butanediol and 0.01-0.1 part of ergothioneine; 0.001-0.005 part of genistein, 1-5 parts of bisabolol, 15-30 parts of dew grass extract and 1-5 parts of horse chestnut extract. The composition combines allantoin, trehalose, dipropylene glycol, butanediol, ergothioneine, genistein, bisabolol, a dew grass extract and a horse chestnut extract, and different active ingredients act together to promote rapid metabolism of cutin, dredge sebaceous gland duct openings, enable sebum secreted by skin to be rapidly discharged, improve acne removing effect and stability of the acne removing composition, and reduce recurrence rate of acne.

Description

Acne-removing composition and preparation method and application thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to an acne-removing composition, and a preparation method and application thereof.

Background

Sebaceous glands are very active at birth of the infant, such as scab; the sebaceous glands wake up from the dormant period after the age of 7 and start a wild agitation growth mode; the 12-18 years of age are active peak periods. Generally, the activity of sebaceous glands decreases by 20% to 30% every decade, starting around 20 years of age. People are starved for oil in the middle-aged, because sebaceous glands are not active and there is less oil secretion, but why many 30+ people still have acne on their faces. In the past, acnes have been produced due to excessive secretion of grease, which gives propionibacterium acnes too much nutrition, causes excessive multiplication of propionibacterium acnes, and finally produces pimples, acnes, pustules and the like. Since the 30+ group had no sebaceous glands active, less greasy, and the vaccinia had peaked. The reason for this is that there may be other causes of acne, and previously the dermatologist has found that inflammation may be involved in the process of forming acne earlier than we thought to be in the process of diagnosing the acne population. Where no acne is present, a micro-inflammatory condition under the facial skin has begun. It can be explained that why 30+ middle-aged people have high pressure, have acne in physiological period, stay up and the like, and the actions are to continuously stimulate the renin angiotensin system and hypothalamus-pituitary-adrenal axis, so that skin and various accessory organs secrete corticotropin to release hormone, cortisol and the like, and the hair follicle has abnormal keratinization, acne is caused, and oil is discharged. For the 30+ long acne population, grease secretion is the result of long acne and not the cause. Therefore, adult 30+ acne cannot be focused on grease secretion, and is more required to pay attention to the micro-inflammation of the skin and the fragile and broken skin barrier caused by the micro-inflammation.

Most of acne removing products in the market solve the acne problem in all ages from the aspects of controlling oil, diminishing inflammation, promoting sebum exfoliation and killing propionibacterium acnes. The skilled artisan found that these products were not expected to have a 30+ vaccinia effect in adults and frequently relapsed. After the products on the market are used, the acne is eliminated, the trouble of acne marks exists, and the whitening products are needed to restore the skin color.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides an acne-removing composition, and a preparation method and application thereof.

In order to achieve the above purpose, the technical scheme adopted by the present disclosure is as follows: in one aspect, an acne-removing composition is provided, which comprises the following components in parts by weight: 1-5 parts of allantoin, 1-5 parts of trehalose, 20-35 parts of dipropylene glycol, 5-10 parts of butanediol, 0.01-0.1 part of ergothioneine, 0.001-0.005 part of genistein, 1-5 parts of bisabolol, 15-30 parts of a dew grass extract and 1-5 parts of a horse chestnut extract.

The composition combines allantoin, trehalose, dipropylene glycol, butanediol, ergothioneine, genistein, bisabolol, dew grass extract and horse chestnut extract, aims at different paths and targets of acne growth of 30+ people, and different active ingredients act together to promote rapid metabolism of cutin and dredge sebaceous gland duct orifices, so that sebum secreted by skin is discharged rapidly, the acne removing effect and stability of the acne removing composition can be obviously improved, and the recurrence rate of acne is reduced.

In the acne removing composition, the barrier repairing promoting component is allantoin, trehalose, dipropylene glycol and butanediol, the anti-inflammatory component is ergothioneine, genistein and bisabolol, and the cutin refreshing promoting component is a dew grass extract and a horse chestnut extract; wherein the anti-inflammatory component can control further development of acne, the barrier repairing component can repair damage of skin epidermis barrier caused by work such as night and high pressure of middle-aged people (skin epidermis is fragile and can be more easily stimulated to skin by metabolites of Propionibacterium acnes), and the keratinization promotion update can dissolve blocked hair follicle keratinization abnormality from the source, so that oxygen can flow into hair follicle, and an anoxic environment in the hair follicle (the anoxic environment is suitable for proliferation and development of Propionibacterium acnes) can not be caused; namely, the anti-inflammatory acne-proof skin-care composition resists further development of the acne, the barrier repairing composition repairs the skin damaged by acne growth, the cutin-promoting renewal composition can accelerate metabolism of the skin, pores are smoother to breathe, acne marks are not easy to leave, and the synergistic effect of the barrier repairing composition and the cutin-promoting renewal composition can effectively remove the acne and prevent the acne marks from leaving.

The extract of the herba lycopodii contains beta ecdysone which can remove excessive oxidation of free radicals, prevent the skin from being damaged by active oxygen, promote proliferation of skin mononuclear cells and mucosa elastin and promote regeneration of skin epithelial cells; in addition, the ecdysone can inhibit androgens in skin, reduce oil production of skin, and make skin smoother and more moist. The horse chestnut extract contains aescin, which can remove free radicals, reduce oxidative stress injury, promote synthesis of collagen, and improve whitening effect of the acne-removing composition and reduce recurrence rate of vaccinia due to synergistic effect of the aescin extract. In addition, aescin can inhibit inflammatory reaction, reduce inflammatory cell infiltration and release of inflammatory mediators, and act together with anti-inflammatory component to improve anti-inflammatory effect of acne-removing composition.

In one embodiment, the allantoin may be, but is not limited to, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, preferably 2-4 parts;

The trehalose may be, but is not limited to, 1 part, 1.3 parts, 1.8 parts, 2 parts, 2.7 parts, 3 parts, 3.3 parts, 4 parts, 4.4 parts, 5 parts, preferably 2.5-4.5 parts;

The weight parts of the dipropylene glycol can be, but are not limited to, 20 parts, 22 parts, 24 parts, 26 parts, 28 parts, 30 parts, 33 parts, 35 parts, preferably 25-30 parts;

The weight parts of the butanediol can be, but are not limited to, 5 parts, 5.5 parts, 5.8 parts, 6.2 parts, 6.4 parts, 6.8 parts, 7 parts, 7.5 parts, 7.8 parts, 8 parts, 8.5 parts, 9 parts, 9.3 parts, 9.6 parts, 10 parts, preferably 6-8 parts;

The weight parts of ergothioneine can be, but are not limited to, 0.01 parts, 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, 0.09 parts, 0.1 parts, preferably 0.03-0.07 parts;

the genistein may be, but not limited to, 0.001 part, 0.002 part, 0.003 part, 0.004 part, 0.005 part;

The weight parts of the bisabolol may be, but are not limited to, 1 part, 1.2 parts, 1.7 parts, 2 parts, 2.3 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.2 parts, 4.8 parts, 5 parts, preferably 2-4.5 parts;

the weight parts of the dew grass extract may be, but are not limited to, 15 parts, 17 parts, 19 parts, 21 parts, 24 parts, 26 parts, 28 parts, 30 parts, preferably 20-25 parts;

The horse chestnut extract may be, but is not limited to, 1 part, 1.3 parts, 1.5 parts, 2 parts, 2.1 parts, 2.4 parts, 3 parts, 3.6 parts, 4 parts, 4.3 parts, 4.8 parts, 5 parts, preferably 2.5-4 parts.

In one embodiment, the mass content of beta-ecdysone in the dew grass extract is 0.1-0.5%, such as 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, and the disclosure is not limited thereto.

Herein, the dew grass extract may be purchased as a commercial product or may be self-made. The preparation process parameters of the dew grass extract are adjusted to obtain the dew grass extract with the beta-ecdysone content of 0.1-0.5%, and the obtained dew grass extract is yellow transparent liquid.

Specifically, the preparation method of the dew grass extract comprises the following steps:

Adding herba Cynanchi Paniculati into water, reflux extracting at 60deg.C, concentrating the extractive solution, and purifying to obtain herba Cynanchi Paniculati extract.

In one embodiment, the aesculin extract has a mass content of 68-72%, such as 68%, 39%, 70%, 71%, 72%, and the disclosure is not limited thereto.

Herein, commercial products may be purchased or homemade. The horse chestnut extract with the content of aescin of 68-72% is obtained by adjusting the preparation process parameters of the horse chestnut extract.

Specifically, the preparation method of the horse chestnut extract comprises the following steps: adding horse chestnut into ethanol water solution, extracting at 60deg.C, concentrating the extractive solution, purifying, and drying to obtain horse chestnut extract.

In another aspect, a method for preparing the acne-removing composition is provided, comprising the steps of: uniformly mixing allantoin, trehalose, ergothioneine, genistein and horse chestnut extract, adding dipropylene glycol, performing first ultrasonic treatment, adding butanediol, performing second ultrasonic treatment, adding herba Cynomorii extract, uniformly mixing, and filtering to obtain acne-removing composition; the parameters of the first ultrasonic treatment are as follows: the power is 200-600w, the time is 10-30min, the frequency is 10-30Hz, and the temperature is 20-50 ℃; the parameters of the second ultrasonic treatment are as follows: the power is 100-400w, the time is 5-15min, the frequency is 5-15Hz, and the temperature is 20-50 ℃; the parameters of the filtration are as follows: the pore diameter of the filter membrane is 0.01-0.2 μm.

The anti-acne composition is prepared by ultrasonic, and allantoin and trehalose can form stable hydrogen-like bonds with dipropylene glycol and/or butanediol; promoting mutual fusion of barrier repair component, anti-inflammatory component, and keratolytic component to form stable and effective composition; wherein, the parameters of the first ultrasonic treatment, the parameters of the second ultrasonic treatment and the pore diameter of the filter membrane used for filtering are key factors influencing the stability of the acne-removing composition, and when the parameters of the first ultrasonic treatment, the parameters of the second ultrasonic treatment and the pore diameter of the filter membrane used for filtering are not within the scope of the disclosure, the stability of the acne-removing composition is obviously reduced.

Herein, the power of the first ultrasound may be 200W, 230W, 270W, 300W, 320W, 360W, 400W, 450W, 500W, 540W, 600W; the time of the first ultrasonic treatment can be 10min, 12min, 15min, 17min, 20min, 23min, 25min, 28min, 30min; the frequency of the first ultrasonic wave can be 10Hz, 15Hz, 20Hz, 25Hz and 30Hz; the temperature of the first ultrasonic treatment can be 20 ℃, 25 ℃, 30 ℃, 35 ℃,40 ℃,45 ℃ and 50 ℃; the parameters of the above first ultrasonic treatment are not limited to the values listed above, and other values within the range not listed are equally applicable.

Herein, the power of the second ultrasound may be 100W, 120W, 150W, 200W, 220W, 250W, 300W, 350W, 400W; the time of the second ultrasonic treatment can be 5min, 6min, 7min, 8min, 9min, 10min, 11min, 12min, 13min, 14min, 15min; the frequency of the second ultrasonic wave can be 5Hz, 7Hz, 9Hz, 11Hz, 13Hz and 15Hz; the temperature of the second ultrasound may be 20 ℃, 23 ℃, 28 ℃,30 ℃, 36 ℃, 42 ℃, 44 ℃,50 ℃; the parameters of the above first ultrasonic treatment are not limited to the values listed above, and other values within the range not listed are equally applicable.

Herein, the pore size of the filter membrane may be 0.01 μm, 0.05 μm, 0.08 μm, 0.1 μm, 0.12 μm, 0.015 μm, 0.17 μm, 0.2 μm, and the disclosure is not limited thereto.

In yet another aspect, a cosmetic is provided that contains the acne-removing composition.

In one embodiment, the anti-acne composition has a mass of 3-8% of the total mass of the cosmetic. Herein, the cosmetic may comprise 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8% of the anti-acne composition based on the mass of the cosmetic; the present disclosure is not limited thereto; the acne-removing and whitening effects of the cosmetics can be enhanced by adding the acne-removing composition into the cosmetics.

In addition to the above-mentioned extracts, the compositions used according to the invention generally comprise a physiologically acceptable and preferably cosmetically acceptable medium, meaning a medium suitable for contact with human skin without toxicity, incompatibility, instability or allergic response, in particular without causing discomfort (redness, tightness, stinging). Advantageously, the cosmetic product may be in the form of a powder, emulsion, microemulsion, nanoemulsion, suspension, solution, lotion, cream, aqueous or hydroalcoholic gel, foam, serum, solution or dispersion for aerosols or lipid vesicle dispersions. In the case of an emulsion, it may be a water-in-oil or oil-in-water emulsion.

In addition to the acne-removing composition of the present disclosure, the cosmetic may further comprise:

one or more humectants, for example, selected from the group consisting of amino acids, chondroitin sulfate, diglycerol, erythritol, fructose, glucose, glycerol polymers, ethylene glycol, 1,2, 6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysates, inositol, lactitol, maltitol, maltose, mannitol, natural moisturizing factor, PEG-15 butanediol, polyglycerol sorbitol, salts of pyrrolidone carboxylic acid, potassium PCA, propylene glycol, sodium glucuronate, sodium PCA, sorbitol, sucrose, trehalose, urea, xylitol, and mixtures thereof.

In certain aspects of the invention, the composition does not comprise an emulsifier. However, in other aspects, the composition may comprise one or more emulsifiers. Non-limiting examples include esters of glycerin, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol dehydrate, carboxylic acid copolymers, esters and ethers of glucose, ethoxylated ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactylates, fatty acid salts, DEA oleyl alcohol polyoxyethylene-3 ether phosphates, and mixtures thereof.

Non-limiting examples of one or more thickeners include carboxylic acid polymers, crosslinked polyacrylate polymers, polyacrylamide polymers, polysaccharides, and gums. Examples of commercially available carboxylic acid polymers include carbomers, which are homopolymers of acrylic acid crosslinked with allyl ethers of sucrose or pentaerythritol. Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Non-limiting examples of gums include gum arabic, agar-agar, algin, alginic acid, ammonium alginate, branched starch, calcium alginate, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, carob gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

Non-limiting examples of preservatives that may be used in the context of the present invention include quaternary ammonium salt preservatives (e.g., polyquaternium-73), parabens (e.g., methylparaben), phenoxyethanol, sorbic acid, sodium thimerosal, 1,2 hexanediol, 1,2 pentanediol, and like polyols, or combinations thereof.

Non-limiting examples of oils that may be used in the context of the present invention include coriander oil, thyme oil, pimenta oil, rose oil, garden balsam oil, bergamot oil, cedar oil, chamomile oil, sage oil, sclareum oil, clove oil, fennel oil, olibanum oil, geranium oil, white pool seed oil, caprylic/capric triglyceride, or combinations thereof.

In one embodiment, the cosmetic product is a cream and the cream comprises the following components in weight percent: 5-10% of humectant, 0.2-0.5% of thickener, 8-15% of grease, 4-8% of emulsifier, 3-8% of acne-removing composition, 1-2% of preservative and the balance of water.

The preparation method of the face cream comprises the following steps:

uniformly mixing humectant, thickener and water according to a certain proportion, and preserving heat of the obtained mixed solution at 80-90 ℃ for 25-40min to obtain phase A; uniformly mixing the grease and the emulsifying agent, and preserving the temperature of the obtained mixed solution at 80-90 ℃ for 25-40min to obtain a phase B;

Adding phase B into phase A at 500-1000r/min, homogenizing the obtained mixture at 1000-2000r/min for 4-6min, cooling to 55-65deg.C, adding antiseptic, stirring, cooling to 40-45deg.C, adding acne removing composition, and stirring to obtain facial cream.

In one embodiment, the cosmetic is an essence, which comprises the following components in percentage by weight: 5-10% of humectant, 0.1-0.5% of thickener, 0.5-1.5% of preservative, 3-8% of acne-removing composition and the balance of water.

The preparation method of the essence is as follows: uniformly mixing humectant, thickener and water according to a certain proportion, preserving heat at 80-90deg.C for 30-60min, cooling to 55-65deg.C, adding antiseptic, stirring uniformly, cooling to 40-45deg.C, adding acne removing composition, and stirring uniformly to obtain essence.

Compared with the prior art, the beneficial effects of the present disclosure are: allantoin, trehalose, dipropylene glycol, butanediol, ergothioneine, genistein, bisabolol, dew grass extract and horse chestnut extract are combined, and different active ingredients are combined for different paths and targets of acne growth of 30+ people to promote rapid metabolism of cutin and dredge sebaceous gland duct orifices, so that sebum secreted by skin is rapidly discharged, the acne removing effect and stability of the acne removing composition can be obviously improved, and the recurrence rate of vaccinia is reduced.

Detailed Description

For a better understanding of the objects, technical solutions and advantages of the present disclosure, the present disclosure will be further described with reference to specific examples and comparative examples, which are intended to be in detail, not to be limiting of the present disclosure. All other embodiments, which can be made by one of ordinary skill in the art without making any inventive effort, are intended to be within the scope of the present disclosure. The experimental reagents and apparatus to which the present disclosure is directed are common reagents and apparatus unless otherwise indicated.

The following description of the raw materials used in the examples and comparative examples is provided, but is not limited to these materials:

the preparation method of the dew grass extract is self-made and comprises the following steps: adding herba Cynanchi Paniculati into water, reflux-extracting at 60deg.C for 65min for 3 times, mixing extractive solutions, concentrating, and removing impurities to obtain yellow transparent liquid which is herba Cynanchi Paniculati extract with beta ecdysone content of 0.3%.

The horse chestnut extract is self-made, and the preparation method is as follows: adding horse chestnut into ethanol water solution, extracting at 60deg.C for 55min for 3 times, mixing extractive solutions, concentrating, purifying with 101 macroporous resin, and lyophilizing to obtain yellow powder which is horse chestnut extract, wherein the mass content of aescin in horse chestnut extract is 70%.

Example 1

An embodiment of the acne-removing composition, essence, face cream and a preparation method thereof are disclosed.

The embodiment provides an acne-removing composition, which comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

The embodiment provides a preparation method of an acne-removing composition, which comprises the following steps:

Uniformly mixing allantoin, trehalose, ergothioneine, genistein and horse chestnut extract, adding dipropylene glycol, performing first ultrasonic treatment, then adding butanediol, performing second ultrasonic treatment, finally adding herba Cynomorii extract, uniformly mixing, and filtering with a filter membrane with a pore diameter of 0.1 μm to obtain filtrate, namely an acne-removing composition;

Wherein, the parameters of the first ultrasonic treatment are as follows: the power is 400w, the time is 20min, the frequency is 20Hz, and the temperature is 35 ℃; the parameters of the second ultrasonic treatment are as follows: the power is 200w, the time is 10min, the frequency is 10Hz, and the temperature is 40 ℃.

The embodiment provides essence, which comprises the following components in percentage by mass: 3% of glycerol, 4.5% of butanediol, 0.3% of methyl cellulose, 0.5% of 1, 2-hexanediol, 0.5% of p-hydroxyphenylethanol, 5% of acne-removing composition and the balance of water;

The preparation method of the essence comprises the following steps: uniformly mixing glycerol, butanediol, methylcellulose and water according to a certain proportion, preserving the temperature of the obtained mixed solution at 85 ℃ for 30min, cooling to 60 ℃, adding 1, 2-glycol and p-hydroxyphenylethanol, uniformly stirring, cooling to 45 ℃, adding the acne-removing composition, and uniformly stirring to obtain the essence.

The embodiment also provides a face cream, which comprises the following components in percentage by mass: 4% of glycerol, 4% of propylene glycol, 0.2% of xanthan gum, 0.2% of cellulose, 6% of white pool seed oil, 5% of caprylic/capric triglyceride, 4% of sorbitan sesquioleate, 20% of cetostearyl alcohol polyether-20%, 1,2 hexanediol 1.0%, 0.5% of phenoxyethanol, 5% of acne-removing composition and the balance of water;

The preparation method of the face cream comprises the following steps:

uniformly mixing glycerol, propylene glycol, xanthan gum, cellulose and water according to a certain proportion, and preserving the temperature of the obtained mixed solution at 85 ℃ for 30min to obtain a phase A;

uniformly mixing the white pool flower seed oil, the caprylic/capric triglyceride, the sorbitan sesquioleate and the cetostearyl alcohol polyether-20 according to a proportion, and preserving the temperature of the obtained mixed solution at 85 ℃ for 30min to obtain a phase B;

Adding phase B into phase A at 800r/min, homogenizing the mixture at 1500r/min for 5min, cooling to 60deg.C, adding 1,2 hexanediol, stirring, cooling to 45deg.C, adding acne removing composition, and stirring to obtain facial cream.

Example 2

The acne-removing composition of the embodiment comprises the following components in parts by weight: 4 parts of allantoin, 2 parts of trehalose, 25 parts of dipropylene glycol, 8 parts of butanediol, 0.06 part of ergothioneine, 0.002 parts of genistein, 2 parts of bisabolol, 20 parts of a dew grass extract and 2 parts of a horse chestnut extract.

The acne-removing composition of this example was prepared using the preparation method of the acne-removing composition of example 1.

The composition of the acne-removing composition of the present example was used to prepare the essence of the present example according to the composition of the essence of example 1 and the preparation method thereof.

The composition of the acne-removing composition of this example was used to prepare the cream of this example according to the composition of the cream of example 1 and the preparation method thereof.

Example 3

The acne-removing composition of the embodiment comprises the following components in parts by weight: 1 part of allantoin, 5 parts of trehalose, 20 parts of dipropylene glycol, 5 parts of butanediol and 0.01 part of ergothioneine; 0.005 part of genistein, 1 part of bisabolol, 30 parts of a dew grass extract and 5 parts of a horse chestnut extract.

Example 4

The acne-removing composition of the embodiment comprises the following components in parts by weight: 5 parts of allantoin, 1 part of trehalose, 35 parts of dipropylene glycol, 10 parts of butanediol and 0.1 part of ergothioneine; 0.001 part of genistein, 5 parts of bisabolol, 15 parts of a dew grass extract and 1 part of a horse chestnut extract.

Example 5

The acne-removing composition of the embodiment comprises the following components in parts by weight: 1 part of allantoin, 5 parts of trehalose, 35 parts of dipropylene glycol, 10 parts of butanediol and 0.1 part of ergothioneine; 0.005 part of genistein, 1 part of bisabolol, 30 parts of a dew grass extract and 5 parts of a horse chestnut extract.

Example 6

The acne-removing composition of the embodiment comprises the following components in parts by weight: 5 parts of allantoin, 1 part of trehalose, 20 parts of dipropylene glycol, 5 parts of butanediol and 0.01 part of ergothioneine; 0.005 part of genistein, 1 part of bisabolol, 30 parts of a dew grass extract and 5 parts of a horse chestnut extract.

Example 7

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 300w, the ultrasonic time is 25min, the ultrasonic frequency is 15Hz, and the ultrasonic temperature is 40 ℃.

Example 8

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 200w, the ultrasonic time is 30min, the ultrasonic frequency is 10Hz, and the ultrasonic temperature is 20 ℃.

Example 9

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 200w, the ultrasonic time is 30min, the ultrasonic frequency is 30Hz, and the ultrasonic temperature is 50 ℃.

Example 10

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 600w, the ultrasonic time is 10min, the ultrasonic frequency is 10Hz, and the ultrasonic temperature is 20 ℃.

Example 11

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the ultrasonic power is 600w, the ultrasonic time is 10min, the ultrasonic frequency is 30Hz, and the ultrasonic temperature is 50 ℃.

Example 12

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 300w, the ultrasonic time is 12min, the ultrasonic frequency is 9Hz, and the ultrasonic temperature is 30 ℃.

Example 13

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 100w, the ultrasonic time is 15min, the ultrasonic frequency is 15Hz, and the ultrasonic temperature is 20 ℃.

Example 14

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 100w, the ultrasonic time is 15min, the ultrasonic frequency is 5Hz, and the ultrasonic temperature is 50 ℃.

Example 15

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 400w, the ultrasonic time is 5min, the ultrasonic frequency is 5Hz, and the ultrasonic temperature is 20 ℃.

Example 16

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 400w, the ultrasonic time is 5min, the ultrasonic frequency is 15Hz, and the ultrasonic temperature is 50 ℃.

Example 17

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the pore size of the filter membrane was 0.12um.

Example 18

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the pore size of the filter membrane was 0.01um.

Example 19

The composition of the acne-removing composition of this example is the same as that of example 1, and the preparation method of the acne-removing composition of this example is different from that of the acne-removing composition of example 1 only in that: the pore size of the filter membrane was 0.2um.

Comparative example 1

The acne-removing composition, essence and face cream disclosed by the disclosure are one comparative example of the preparation method of the acne-removing composition, the essence and the face cream.

The acne-removing composition of the comparative example comprises the following components in parts by weight: 0.9 part of allantoin, 5.1 parts of trehalose, 19.9 parts of dipropylene glycol, 4.9 parts of butanediol and 0.009 part of ergothioneine; genistein 0.006 parts, bisabolol 0.9 parts, dew grass extract 14.9 parts, horse chestnut extract 5.1 parts.

The anti-acne composition of this comparative example was prepared using the preparation method of the anti-acne composition of example 1.

The composition of the essence of the comparative example 1 and the preparation method thereof are used for preparing the essence of the comparative example.

The composition of the cream of example 1 and the preparation method thereof were used to prepare the cream of the comparative example.

Comparative example 2

The acne-removing composition of the comparative example comprises the following components in parts by weight: 5.1 parts of allantoin, 0.9 part of trehalose, 35.1 parts of dipropylene glycol, 10.1 parts of butanediol and 0.11 part of ergothioneine; genistein 0.0009 parts, bisabolol 5.1 parts, dew grass extract 30.1 parts, horse chestnut extract 0.9 parts.

Comparative example 3

The acne-removing composition of the comparative example comprises the following components in parts by weight: 0.9 part of allantoin, 0.9 part of trehalose, 19.9 parts of dipropylene glycol, 4.9 parts of butanediol and 0.009 part of ergothioneine; 0.0009 parts of genistein, 0.9 parts of bisabolol, 14.9 parts of dew grass extract and 0.9 part of horse chestnut extract.

Comparative example 4

The acne-removing composition of the comparative example comprises the following components in parts by weight: 5.1 parts of allantoin, 5.1 parts of trehalose, 35.1 parts of dipropylene glycol, 10.1 parts of butanediol and 0.11 part of ergothioneine; genistein 0.006 parts, bisabolol 5.1 parts, dew grass extract 30.1 parts, horse chestnut extract 5.1 parts.

Comparative example 5

The acne-removing composition of the comparative example comprises the following components in parts by weight: 6 parts of allantoin, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 6

The acne-removing composition of the comparative example comprises the following components in parts by weight: 6 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 7

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 34.5 parts of dipropylene glycol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 8

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 34.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 9

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 34.5 parts of propylene glycol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 10

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of propylene glycol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 11

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of glycerol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 12

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of madecassoside, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 13

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of panthenol, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 14

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.053 parts of ergothioneine, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 15

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.053 parts of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 16

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of dipotassium glycyrrhizinate, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 17

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of asiaticoside, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 18

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of soybean isoflavone, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of a horse chestnut extract.

Comparative example 19

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol and 26 parts of a dew grass extract.

Comparative example 20

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol and 26 parts of horse chestnut extract.

Comparative example 21

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of salicylic acid.

Comparative example 22

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of white willow bark extract and 3 parts of horse chestnut extract.

Comparative example 23

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of mandelic acid.

Comparative example 24

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of gluconolactone.

Comparative example 25

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of lactic acid.

Comparative example 26

The acne-removing composition of the comparative example comprises the following components in parts by weight: 3 parts of allantoin, 3 parts of trehalose, 27 parts of dipropylene glycol, 7.5 parts of butanediol, 0.05 part of ergothioneine, 0.003 part of genistein, 3 parts of bisabolol, 23 parts of a dew grass extract and 3 parts of lactobionic acid.

Comparative example 27

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: stirring was used instead of first sonication.

Comparative example 28

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the first ultrasonic parameters are as follows: ultrasonic power 190w, ultrasonic time 32min, ultrasonic frequency 9Hz, ultrasonic temperature 51 ℃.

Comparative example 29

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 190w, the ultrasonic time is 32min, the ultrasonic frequency is 32Hz, and the ultrasonic temperature is 19 ℃.

Comparative example 30

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 610w, the ultrasonic time is 9min, the ultrasonic frequency is 9Hz, and the ultrasonic temperature is 51 ℃.

Comparative example 31

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the first ultrasound are: the power is 610w, the ultrasonic time is 9min, the ultrasonic frequency is 32Hz, and the ultrasonic temperature is 19 ℃.

Comparative example 32

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: stirring was used instead of the second sonication.

Comparative example 33

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 90w, the ultrasonic time is 16min, the ultrasonic frequency is 4Hz, and the ultrasonic temperature is 51 ℃.

Comparative example 34

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 90w, the ultrasonic time is 16min, the ultrasonic frequency is 16Hz, and the ultrasonic temperature is 19 ℃.

Comparative example 35

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 410w, the ultrasonic time is 4min, the ultrasonic frequency is 4Hz, and the ultrasonic temperature is 51 ℃.

Comparative example 36

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the parameters of the second ultrasound are: the power is 410w, the ultrasonic time is 4min, the ultrasonic frequency is 16Hz, and the ultrasonic temperature is 19 ℃.

Comparative example 37

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: no filtration treatment was performed.

Comparative example 38

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the pore size of the filter membrane was 0.005. Mu.m.

Comparative example 39

The composition of the acne-removing composition of this comparative example is the same as that of example 1, and the preparation method of the acne-removing composition of this comparative example is different from that of the acne-removing composition of example 1 only in that: the pore size of the filter membrane was 0.25. Mu.m.

Effect example 1

This effect example tests the stability of the anti-acne compositions obtained in example 1, examples 7-19 and comparative examples 27-39.

The test method is as follows: the acne-removing compositions obtained in example 1, examples 7 to 19 and comparative examples 27 to 39 were left at room temperature, 4 ℃, -18 ℃, 45 ℃ and 50 ℃ for 3 months, respectively, and after comparing the colors under other conditions with the color of 4 ℃ as a reference, the appearance was scored, the number of the scores was 10, the color no difference from the color of 4 ℃ was 10, the total discoloration was 0, and the like. Wherein, the dew grass extract is yellow liquid, and the horse chestnut extract is yellow powder, so the acne-removing composition disclosed by the invention is light yellow transparent liquid in appearance. The experimental results are shown in Table 1, wherein the precipitation amount is 1-5% of the liquid volume and is slight precipitation, the precipitation amount is 5-15% of the liquid volume and is moderate precipitation, and the precipitation amount is more than 15% and is severe precipitation.

TABLE 1

From the experimental data in table 1, the acne-removing composition of the present disclosure has good stability. If the ultrasonic treatment is not carried out, the compatibility of each component is reduced, so that the effective components in the acne-removing composition are easy to separate out after the acne-removing composition is kept for a long time, and the stability of the acne-removing composition is reduced; in addition, when the ultrasonic parameters in the process of preparing the acne-removing composition are not in the scope of the invention, allantoin or trehalose cannot form relatively stable hydrogen bonds with dipropylene glycol and butanediol, and the composition is easy to damage at low temperature and easy to generate precipitation after being restored to room temperature.

The pore diameter of the filter membrane used for filtering is another key factor affecting the stability of the acne-removing composition, and the pore diameters of all the filter membranes are too small, so that macromolecular components in the dewdrop grass extract or the horse chestnut extract are filtered and intercepted, the micromolecular pigment in the dewdrop grass is reserved, and the macromolecular components have the function of stabilizing the color appearance in the polyalcohol solution, and are filtered out, so that the appearance of the acne-removing composition is easier to change; the pore size of the filtering membrane is too large, so that the acne-removing composition contains part of undissolved impurities or other molecular components, the undissolved impurities or other molecular components are precipitated at low temperature, and the stability of the acne-removing composition is reduced, and therefore, the appearance stability of the acne-removing composition can be effectively improved by filtering within the pore size range of the acne-removing composition.

The acne-removing composition is of critical importance for the quality of the cosmetics containing the acne-removing composition, for example, the stability of the acne-removing composition is poor, appearance quality problems can be caused to the cosmetics containing the acne-removing composition, and the effect of the cosmetics containing the acne-removing composition can be reduced.

Effect example 2

This effect example shows the effect of the anti-acne compositions obtained in examples 1 to 6 and comparative examples 1 to 18 on inflammatory factors, APQ3 protein and microbial defenses in dermatitis mice. The test method is as follows:

Atopic dermatitis-like mouse model acquisition: 200 BALB/c mice were shaved with an infant shaver for 24 hours before the experiment, the back area of the mice was shaved with about 2cm×4cm hairs, the residual hairs were then shaved cleanly with a razor and divided into 2 groups, a normal group of 8 mice, and a model group of 192 mice, 1% DNCB was applied to the back test area of the model group mice for 100. Mu.L on the first day, 1% DNCB was applied to the back test area for 100. Mu.L every 3 days, and 1% OX was applied to the back test area for 100. Mu.L for 7 days for boosting, and the induction was repeated weekly for 3 weeks as described above to prepare an atopic dermatitis-like mouse model.

The experimental method comprises the following steps: after the atopic dermatitis-like mouse model was made, it was divided into 25 groups, a blank group and examples 1 to 6, comparative examples 1 to 18 groups, each group was given composition intervention (placebo was given to the blank group), 100 μl each time was uniformly smeared on the back test area, 1 time/day, and 15 days of intervention; another normal group was also given placebo as a baseline group for each test index.

The detection method comprises the following steps: after 15 days of intervention of the corresponding test products, the skin lesions of the back test areas of the mice are collected, the expression levels of IL-6, IL-8 and APQ3 in the skin lesions are detected by using an ELISA kit, and the expression levels of cathelicidin and beta-defensin (MBD 1) proteins are detected by using a Westernblot method after protein extraction.

The test results are shown in Table 2.

TABLE 2

Inflammatory factors are closely related to the immune system of mice, and the immune system participates in regulating the release of inflammatory factors, wherein inflammatory factors 1L-6 and 1L-8 are regulated by the immune system; the epidermis APQ3 protein is epidermis aquaporin, which can promote epidermis to obtain water from dermis, and is one of moisture-keeping barrier indexes of skin; both Cathelicidin and beta-defensin (MBD 1) are closely related to the expression of epidermoid antimicrobial peptides which inhibit the colonization of the skin surface by harmful flora and increase the microbial barrier of the skin. As can be seen from table 2, the anti-acne compositions of examples 1 to 6 have good repairing effects on skin immune barrier, moisture barrier (water barrier) and microbial barrier, which indicates that the collocation and the proportion of the repairing component and the soothing component in the anti-acne composition have great influence on the protecting and repairing effects of the anti-acne composition.

Effect example 3

This effect example tests the anti-acne effect of the essences and creams obtained in example 1 and comparative examples 19-26.

The test method is as follows: 100 volunteers with 1-2 grade acnes on the face were recruited, 10 people in each group, the essence and the face cream of the blank group did not contain any acne removing composition, and the composition and content of the other components were the same as those of the essence and the face cream of example 1. The test group used the essence and the face cream obtained in example 1 and comparative examples 19 to 26, respectively, for 14 days, and used a VISA instrument to test the decrease in the acne area and the skin a value (a value, which is the red skin content, representing the erythema of the dermis layer of the skin, representing the inflammatory condition of the skin) in the long acne area at 0 day, 7 day and 14 day, respectively, and calculated the improvement rate with the data of 0 day; feeding back whether allergy or other skin problems occurred or not when the product was used at 14 days; the volunteers were asked whether or not to again develop vaccinia 28 days after the end of use of the product and a 56 day return visit. The test results are shown in Table 3.

TABLE 3 Table 3

The skin a value around the acne can reflect the condition of skin recovery, the peeling speed of the cutin is increased, and the barrier repairing effect can promote the skin a value around the acne to be reduced; from the comparison of the example 1, the comparative examples 19-36 and the blank group, the essence and the face cream prepared by the invention can quickly eliminate the acnes, and can reduce pigmentation while eliminating the acnes due to good and mild effects of promoting the exfoliating of cutin and repairing damaged skin; the probability of reoccurrence of the vaccinia is low within 2 months after use.

Finally, it should be noted that the above embodiments illustrate the technical solution of the present disclosure and not limit the scope of the present disclosure, and although the present disclosure has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present disclosure may be modified or equally substituted without departing from the spirit and scope of the technical solution of the present disclosure.

Claims

1. The acne-removing composition is characterized by comprising the following components in parts by weight: 1-5 parts of allantoin, 1-5 parts of trehalose, 20-35 parts of dipropylene glycol, 5-10 parts of butanediol and 0.01-0.1 part of ergothioneine; 0.001-0.005 part of genistein, 1-5 parts of bisabolol, 15-30 parts of dew grass extract and 1-5 parts of horse chestnut extract; the content of beta ecdysone in the herba Cynanchi Paniculati extract is 0.1-0.5%;

The preparation method of the acne-removing composition comprises the following steps:

Uniformly mixing allantoin, trehalose, ergothioneine, genistein and horse chestnut extract, adding dipropylene glycol, performing first ultrasonic treatment, adding butanediol, performing second ultrasonic treatment, adding herba Cynomorii extract, uniformly mixing, and filtering to obtain acne-removing composition;

The parameters of the first ultrasonic treatment are as follows: the power is 200-600w, the time is 10-30min, the frequency is 10-30Hz, and the temperature is 20-50 ℃;

The parameters of the second ultrasonic treatment are as follows: the power is 100-400w, the time is 5-15min, the frequency is 5-15Hz, and the temperature is 20-50 ℃;

The parameters of the filtration are as follows: the pore diameter of the filter membrane is 0.01-0.2 μm.

2. The acne-removing composition according to claim 1, wherein the acne-removing composition comprises the following components in parts by weight: 2-4 parts of allantoin, 2.5-4.5 parts of trehalose, 25-30 parts of dipropylene glycol, 6-8 parts of butanediol and 0.03-0.07 part of ergothioneine; 0.001-0.005 part of genistein, 2-4.5 parts of bisabolol, 20-25 parts of dew grass extract and 2.5-4 parts of horse chestnut extract.

3. A method for preparing an anti-acne composition according to any one of claims 1-2, comprising the steps of: uniformly mixing allantoin, trehalose, ergothioneine, genistein and horse chestnut extract, adding dipropylene glycol, performing first ultrasonic treatment, adding butanediol, performing second ultrasonic treatment, adding herba Cynomorii extract, uniformly mixing, and filtering to obtain acne-removing composition;

4. Use of the acne-removing composition according to any one of claims 1-2 in cosmetics.

5. A cosmetic product, characterized in that it contains the acne-removing composition according to any one of claims 1 to 2.

6. The cosmetic according to claim 5, wherein the acne-removing composition has a mass of 3 to 8% of the total mass of the cosmetic.

7. The cosmetic product of claim 5 or 6, wherein the cosmetic product is a face cream and the face cream comprises the following components in weight percent: 5-10% of humectant, 0.2-0.5% of thickener, 8-15% of grease, 4-8% of emulsifier, 3-8% of acne-removing composition, 1-2% of preservative and the balance of water.

8. The cosmetic product according to claim 5 or 6, characterized in that it is a serum comprising the following components in percentage by weight: 5-10% of humectant, 0.1-0.5% of thickener, 0.5-1.5% of preservative, 3-8% of acne-removing composition and the balance of water.