CN115708815A - Nano-fiber supermolecule skin care composition - Google Patents
Nano-fiber supermolecule skin care composition Download PDFInfo
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- CN115708815A CN115708815A CN202210960136.1A CN202210960136A CN115708815A CN 115708815 A CN115708815 A CN 115708815A CN 202210960136 A CN202210960136 A CN 202210960136A CN 115708815 A CN115708815 A CN 115708815A
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- GLGLUQVVDHRLQK-WRBBJXAJSA-N n,n-dimethyl-2,3-bis[(z)-octadec-9-enoxy]propan-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC GLGLUQVVDHRLQK-WRBBJXAJSA-N 0.000 description 1
- QMDUPVPMPVZZGK-UHFFFAOYSA-N n,n-dimethyloctadecan-1-amine;hydrobromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[NH+](C)C QMDUPVPMPVZZGK-UHFFFAOYSA-N 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- SXFKFRRXJUJGSS-UHFFFAOYSA-N olivetolic acid Chemical compound CCCCCC1=CC(O)=CC(O)=C1C(O)=O SXFKFRRXJUJGSS-UHFFFAOYSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- LQKHZXYWZMTTLC-UHFFFAOYSA-M potassium dihydrogen phosphate dodecanoic acid Chemical compound P(=O)([O-])(O)O.C(CCCCCCCCCCC)(=O)O.[K+] LQKHZXYWZMTTLC-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 229940077859 salicyloyl phytosphingosine Drugs 0.000 description 1
- 229940084038 salix alba bark extract Drugs 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- OTKJDMGTUTTYMP-ZWKOTPCHSA-N sphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ZWKOTPCHSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a nano-fiber supermolecule skin care composition, which has the advantages and effects that a mode of directly using active ingredients to prepare cosmetics is replaced, the skin active ingredients are adsorbed in pores of a three-dimensional structure of nano-fibers to form a supermolecule multielement composite material, the stability of the active ingredients in a skin care product system can be improved, the stimulation of the active ingredients to the skin is reduced, the absorption of the active ingredients in the skin is promoted, and the purposes of moistening, moisturizing, repairing, acne removing, blackhead removing, freckle removing, whitening, skin tendering, wrinkle resisting, aging resisting, tightening, relieving, oil controlling, body refreshing, sweat stopping, hair care, hair loss preventing, hair breaking preventing, scurf removing, hair color nursing or hair blackening are achieved. The invention has simple operation and lower cost. The invention has simple operation and lower cost.
Description
Technical Field
The invention relates to the field of cosmetics and medicines, in particular to a nano-fiber supermolecule skin care composition.
Background
In the prior art, most skin active ingredients for whitening, wrinkle resistance, sugar resistance, aging resistance and the like belong to reducing ingredients, are unstable in an emulsion system and are easy to inactivate under the conditions of light, heat and oxygen. Active ingredients also have skin irritation problems, and improper use can cause skin red swelling and pain. Active ingredients also suffer from poor skin absorption. These defects of skin active ingredients such as whitening, anti-wrinkle, anti-sugar, anti-aging, etc. seriously affect the stability and use effect of cosmetics. Patent application No. 201910681023.6 to a supramolecular preparation of retinol and derivatives thereof discloses a method for forming supramolecules with retinol by utilizing the cavitation effect of an inner hydrophobic and outer hydrophilic structure of a macrocyclic molecule of hydroxypropyl gamma-cyclodextrin, and forming a stable supramolecular structure by taking hydroxypropyl methyl cellulose stearyloxy ether, PEG/PPG/polytetramethylene glycol-8/5/3 glycerol as a supramolecular association agent, so as to improve the solubility, stability and permeability of retinol and expand the application range of retinol. The skin care product is generally an oil-in-water emulsion, and the gamma-cyclodextrin and the derivative thereof and the supermolecule association agent have water solubility, the water-soluble supermolecule structure is generally unstable in the oil-in-water emulsion, and the supermolecule structure is easy to collapse under the water-containing environment, cannot well isolate the damage of oxygen and light to active ingredients and cannot protect the active ingredients.
Disclosure of Invention
The invention aims to overcome the defects and provide a novel safe, stable and efficient nano-fiber supermolecule skin care composition for cosmetics or external ointments.
The nano fiber supermolecule skin care composition mainly comprises nano fibers and a skin active ingredient, wherein the nano fibers mainly comprise the nano fibers and the skin active ingredient, the nano fibers comprise 0.2-30 wt% of the nano fiber supermolecule skin care composition, preferably 0.3-20 wt% of the nano fiber supermolecule skin care composition, particularly preferably 0.5-10 wt% of the nano fiber supermolecule skin care composition, and the nano fiber comprises 0.1-10 wt% of the nano fiber supermolecule skin care composition, preferably 0.5-3 wt% of the nano fiber supermolecule skin care composition, more preferably 0.5-3 wt% of the nano fiber supermolecule skin care composition, and more preferably 0.3-10 wt% of the nano fiber. The nanofiber provided by the invention is an insoluble fiber with two similar dimensions and the external dimension of 1 nm-1000 nm in a broad sense, and the external dimension of the remaining dimension is obviously larger than those of the other two dimensions. Insoluble fiber refers to fibers that are not soluble in water. The nano-fiber in the nano-fiber supermolecule skin care composition is preferably insoluble nano dietary fiber, and particularly preferably nano wheat bran dietary fiber, nano sweet potato dietary fiber, nano soybean dietary fiber, nano corn dietary fiber and nano fruit and vegetable fiber. <xnotran> , , , , , , , , , , , , , , , , , , , , , , , , , , , , , A , , Q10, , , C , , , 4- , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , E, </xnotran> Bisabolol, cholesterol, soyasterol, furfuryl sterol, sphinganine, salicyloyl phytosphingosine, tetrahydromagnolol, magnolol, quercus robur oil, hemp seed oil, norway spruce leaf extract, white willow bark extract, and purple coneflower extract. The preparation method of the nano-fiber supermolecule skin care composition comprises the following steps: 1. carrying out high-pressure homogenization treatment on the nanofiber raw material by using a high-pressure homogenizer to enable the nanofiber to be puffed, so that the pores of the nanofiber are enlarged, and the adsorption force of the nanofiber is improved; 2. dehydrating and drying the nanofibers, including but not limited to spray drying, centrifugal dehydration, vacuum dehydration, filter press dehydration; 3. dissolving skin care active ingredient in water, organic solution or oily component to form high concentration water solution, oil solution or organic solution of active ingredient, or emulsifying liposoluble active ingredient into oil-in-water or water-in-oil emulsion, wherein liquid active ingredient can be directly used; 4. mixing the dehydrated or dried nano-fiber in the step two with the high-concentration skin care active ingredient aqueous solution, oil solution, organic solution, emulsion or liquid active ingredient in the step three, stirring uniformly, grinding or homogenizing and emulsifying if necessary, and adsorbing the high-concentration skin care active ingredient in pores of a three-dimensional structure of the nano-fiber under the action of strong adsorption force and polar groups of the nano-fiber to form a particle type multi-component composite material, namely the nano-fiber supermolecule skin care composition; 5. carrying out vacuum deoxidation treatment on the nano-fiber supermolecule skin care composition; 6. the method comprises the following steps of carrying out sealing protection on a nano-fiber supermolecule skin care composition, dissolving a film forming agent in water to form a gel sealing agent, putting the nano-fiber supermolecule skin care composition into a vacuum tank for vacuum deoxidation treatment, stirring the vacuum tank to suck the gel sealing agent, uniformly mixing the gel sealing agent and the deoxidized nano-fiber supermolecule skin care composition, filling nitrogen or inert gas for protection, blocking an outer opening of micropores of nano-fibers in the nano-fiber supermolecule skin care composition through the gel sealing agent, forming a firm protective film on the surface of the nano-fiber supermolecule skin care composition, sealing skin care active ingredients in the micropores of the nano-fibers, preventing skin care active ingredients in the nano-fiber supermolecule skin care composition from exuding, blocking air, and preventing oxygen in the air from oxidizing the skin care active ingredients; 7. cationic liposome protection of residual skin care active ingredients, dissolving cationic liposomes in water to form an aqueous cationic liposome solution, adding the aqueous cationic liposome solution to the nanofiber supramolecular skin care composition protected by gel blocking agent blocking, and stirring uniformly to protect residual skin care active ingredients not adsorbed into the pores of the nanofibers, the cationic liposomes including, but not limited to, hydroxypropyl γ -cyclodextrin, DOTAP ((2, 3-dioleoyl-propyl) -trimethylamine), DOTMA (N- [1- (2, 3-dioleoyl) propyl ] -N, N-trimethylammonium chloride), DODMA (1, 2-dioleyl-3-dimethylamino-propane), DOAB (N, N-dimethyloctadecylammonium bromide), and DC-Chol (cholesterol), N- [1 (2, 3-oxododecylcarbamoyl) propyl ] -N, N-trimethylammonioaminic acid iodide (dddmatma), N- (N ', N' -dimethyl) propylsuccinic acid monoglyceride monoamide (pa-CHEMSH). The cationic liposome is a zwitterionic surfactant, has hydrophilicity and hydrophobicity, is used as a drug carrier, has a wide wrapping range, and can wrap water-soluble substances, fat-soluble substances and amphoteric substances. The addition amount of the cationic liposome is 0.3-30 wt%. The cyclodextrin is a macrocyclic molecule from natural sources, and the inner hydrophobic and outer hydrophilic structures of the cyclodextrin and the residual lipophilic skin care active ingredients which are not absorbed into the micropores of the nanofibers can form supermolecular structures, so that the cyclodextrin can protect the residual skin care active ingredients which are not absorbed into the micropores of the nanofibers. The nano-fiber supramolecular skin care composition is used as a functional raw material of cosmetics or external ointment and is added into a cosmetic or external ointment system to form the cosmetics or external ointment containing the nano-fiber supramolecular skin care composition, the dosage forms include but are not limited to muscle base solution, essence, cream, emulsion, gel, powder, protein honey, mud, wax base, spray, aerosol, paste, cosmeceutical or mask, and because the skin active ingredients are protected in micropores of the nano-fibers, the contact between the skin active ingredients and the air is reduced, and the risk of oxidative inactivation of the skin active ingredients by oxygen in the air is greatly reduced. Because the nano-fiber has light scattering property, the irradiation of light to the skin active ingredients is reduced, and the risk of the inactivation of the skin active ingredients by light is reduced. Because the skin active ingredients are protected in the micropores of the nano fibers, the direct contact of the active ingredients and the skin is avoided, and the stimulation of the active ingredients to the skin is reduced. Because the nano-fiber has good absorption performance on the skin, the nano-fiber supermolecule skin care composition can be used as a carrier of skin active ingredients in the absorption process of the nano-fiber, and the active ingredients combined with the nano-fiber are loaded into the skin through the absorption of the nano-fiber, so that the absorption of the active ingredients on the skin is promoted, and the purposes of moistening, moisturizing, repairing, acne removing, blackhead removing, freckle removing, whitening, skin tendering, wrinkle resisting, aging resisting, tightening, soothing, oil controlling, body refreshing, sweat stopping, hair care, hair loss preventing, hair breakage preventing, dandruff removing, hair color caring or hair blackening are achieved. In the cosmetics or the external ointment prepared from the nano-fiber supermolecule skin care composition, the addition amount of the nano-fiber supermolecule skin care composition in the cosmetics or the external ointment is 5-60 wt%, so that the cosmetics or the external ointment containing the nano-fiber supermolecule skin care composition is formed, and the content of the nano-fiber in the cosmetics or the external ointment is 0.1-10 wt%, preferably 0.2-5 wt%, and particularly preferably 0.3-3 wt%. The cosmetics or the external ointment prepared from the nano-fiber supermolecule skin care composition also contain auxiliary components, including a sunscreen agent, a preservative, a bactericide, an emulsifier, a film-forming agent and a stabilizing agent.
The invention has the advantages and effects that the mode of directly using active ingredients to manufacture cosmetics is replaced, the skin active ingredients are absorbed in pores of a three-dimensional structure of the nano fibers to form a supermolecule multi-component composite material, the stability of the active ingredients in a skin care product system is improved, the stimulation of the active ingredients to the skin is reduced, the absorption of the active ingredients in the skin is promoted, and the purposes of moistening, moisturizing, repairing, acne removing, blackhead removing, freckle removing, whitening, skin tendering, wrinkle resisting, aging resisting, tightening, repairing, relaxing, oil controlling, body refreshing, sweat stopping, hair protecting, hair loss preventing, hair breaking prevention, scurf removing, hair color caring or hair blackening are achieved. The invention has simple operation and lower cost.
Detailed Description
Example 1: fiber acne-removing lotion (cream). The components are as follows: 1wt% of nano fiber, 2wt% of glycerol, 3wt% of lactic acid, 2wt% of squalane, 0.2wt% of sodium polyglutamate, 0.5wt% of salicylic acid, 0.1wt% of o-cymene-5-alcohol, 3wt% of 2 peptide and 3 peptide, 2wt% of butanediol, 0.5wt% of polyacrylate cross-linking composition, 2wt% of glycerol stearate, 0.05wt% of 1, 2-hexanediol, 3wt% of p-hydroxyacetophenone and the balance of water. The preparation method comprises the following steps: dissolving water soluble components including glycerol, lactic acid, 2 peptide, 3 peptide, and p-hydroxyacetophenone in deionized hot water, maintaining the temperature at 55-60 deg.C, and stirring for 10 min to obtain water phase. Dissolving film-forming agent sodium polyglutamate and polyacrylate crosslinking composition in hot water, maintaining the temperature at 55-65 deg.C, and stirring for 10 min to obtain film phase. Heating functional components such as glycerol, squalane and salicylic acid to 50-60 deg.C in oil pan, maintaining at 50-60 deg.C, adding nanofiber, and stirring for 10 min to obtain nanofiber supermolecule skin care composition. Heating liposoluble components such as glyceryl stearate, o-cymene-5-alcohol, 1, 2-hexanediol, and butanediol to 55-85 deg.C in oil pan, cooling to 50-60 deg.C, and stirring for 10 min to obtain oil phase. Mixing the water phase and the membrane phase, keeping the temperature at 55-65 deg.C, stirring for 10 min, adding the oil phase, stirring and emulsifying for 10 min, adding the nanometer fiber supermolecule skin care composition, keeping the temperature at 40-50 deg.C, stirring for 5 min to form fiber acne removing emulsion (cream), inspecting, bottling, and packaging.
Example 2: the nanometer fiber freckle-removing and whitening emulsion (cream). The components are as follows: 1.5wt% of nano-fiber, 3wt% of tranexamic acid, 1wt% of retinol, 5wt% of glycerol, 0.5wt% of phenoxyethanol, 0.5wt% of sodium hyaluronate, 0.5wt% of sodium polyglutamate, 0.3wt% of polyacrylate cross-linking composition, 0.05wt% of disodium EDTA, 5wt% of tocopherol acetate (vitamin E), 0.3wt% of bisabolol, 2wt% of squalane, 2wt% of polydimethylsiloxane, 0.6wt% of cetearyl olivetolate, 1.5wt% of ethylhexyl glycerol, and the balance of water. The preparation method comprises the following steps: carrying out high-pressure homogenization treatment on the nanofiber raw material by using a high-pressure homogenizer, and dehydrating and drying the average nanofiber; dissolving film forming agents including sodium hyaluronate and sodium polyglutamate in hot water, keeping the temperature at 55-65 deg.C, and stirring for 10 min to obtain a closed phase. Dissolving tranexamic acid, retinol and glycerol in a small amount of hot water, maintaining the temperature at 50-60 deg.C, and stirring for 3 min to form saturated solution as aqueous functional phase. Heating oily functional components, namely tocopherol acetate (vitamin E) and bisabolol, in an oil pot to 50-60 ℃, keeping the temperature at 50-60 ℃, stirring for 2 minutes to obtain an oily functional phase, adding the nanofiber while stirring, stirring for 10 minutes, adding the aqueous functional phase, stirring for 10 minutes, adding the closed phase, and stirring for 10 minutes to obtain the nanofiber supermolecule skin care composition. Heating fat-soluble components such as squalane, polydimethylsiloxane, cetearyl alcohol olive oleate and ethylhexyl glycerol in an oil pan to 55-85 deg.C, cooling to 50-60 deg.C, and stirring for 10 min to obtain oil phase. Dissolving water soluble components of tranexamic acid, glycerol, phenoxyethanol, sodium hyaluronate and disodium EDTA in deionized hot water, keeping the temperature at 55-65 ℃, stirring for 10 minutes, adding a film forming agent polyacrylate cross-linking composition, keeping the temperature at 55-65 ℃, and stirring for 10 minutes to obtain a water phase. Adding the oil phase into the stirred water phase, continuously stirring for 10 minutes, adding the nano-fiber supermolecule skin care composition, continuously stirring for 10 minutes to form nano-fiber freckle-removing and whitening emulsion (cream), and carrying out inspection, filling and packaging.
Example 3: nano fiber anti-aging emulsion (cream). The components are as follows: dipotassium glycyrrhizinate 0.1wt%, arbutin 2wt%, niacinamide 1wt%, tocopherol acetate 2wt%, retinol 0.1wt%, nanofiber 1wt%, glycerin 5wt%, phenoxyethanol 0.1wt%, gellan gum 0.3wt%, sodium polyglutamate 0.3wt%, sodium hyaluronate 0.2wt%, polyacrylate cross-linking composition 0.3wt%, disodium EDTA 0.05wt%, squalane 2wt%, butanediol 2wt%, glyceryl stearate 2wt%, potassium laurate 3wt%, ethylhexyl glycerin 0.5wt%, and the balance of water. The preparation method comprises the following steps: dissolving film forming agents including sodium hyaluronate and sodium polyglutamate in hot water, keeping the temperature at 55-65 deg.C, and stirring for 10 min to obtain a closed phase. Dissolving arbutin and nicotinamide in small amount of hot water, maintaining the temperature at 40-50 deg.C, and stirring for 3 min to form saturated solution as aqueous functional phase. Heating oily functional components such as tocopherol acetate (vitamin E) and retinol to 50-60 deg.C in oil pan, maintaining at 50-60 deg.C, and stirring for 2 min to obtain oily functional phase. And (3) sucking the oily functional phase into a vacuum stirring cylinder, sucking the nanofiber while stirring, stirring for 10 minutes, sucking the aqueous functional phase while stirring, stirring for 10 minutes, sucking the closed phase while stirring, and stirring for 10 minutes to form the nanofiber supermolecule skin care composition. Heating fat-soluble components squalane, glycerol stearate, potassium laurate phosphate and ethylhexyl glycerol to 55-85 deg.C in an oil pan, cooling to 50-60 deg.C, and stirring for 10 min to obtain oil phase. Dissolving water soluble dipotassium glycyrrhizinate, glycerol, phenoxyethanol, EDTA disodium, and polyacrylate crosslinking composition in deionized hot water, maintaining the temperature at 50-60 deg.C, and stirring for 10 min to obtain water phase. Adding the oil phase into the stirred water phase, continuously stirring for 10 minutes, adding the nano-fiber supermolecule skin care composition, continuously stirring for 10 minutes to form nano-fiber anti-aging emulsion (cream), and inspecting, filling and packaging.
Claims (10)
1. The nano-fiber supermolecule skin care composition is a supermolecule multi-component composite material which is formed by adsorbing skin active ingredients in pores of a three-dimensional structure of nano-fibers by utilizing the strong adsorption capacity of the nano-fibers, mainly contains the nano-fibers and the skin active ingredients, and the nano-fibers are insoluble fibers which have similar external dimensions and are in a generalized nano-scale of 1 nm-1000 nm.
2. The nanofiber supramolecular skin care composition as claimed in claim 1, wherein the content of nanofiber in the nanofiber supramolecular skin care composition is any one of 0.2wt% to 30wt%, preferably 0.3wt% to 20wt%, and particularly preferably 0.5wt% to 10wt%, or the content of nanofiber in cosmetics or external ointments containing the nanofiber supramolecular skin care composition is any one of 0.1wt% to 10wt%, preferably 0.2wt% to 5wt%, and particularly preferably 0.3wt% to 3wt%.
3. The nano-fiber supramolecular skin care composition as claimed in claim 2, wherein nano-fiber in the nano-fiber supramolecular skin care composition is preferably nano-scale insoluble dietary fiber.
4. The nanofiber supramolecular skin care composition as claimed in claim 3, wherein the nanofiber in the nanofiber supramolecular skin care composition is preferably selected from nano wheat bran dietary fiber, nano sweet potato dietary fiber, nano soybean dietary fiber, nano corn dietary fiber and nano fruit and vegetable fiber.
5. Nano-fiber supramolecular skin care composition according to claims 1-4, characterized in that the nano-fibers are preferably insoluble fibers with two dimensions of similar external dimensions and in the narrow sense of nano-scale from 1nm to 100 nm.
6. The nano-fiber supramolecular skin care composition as claimed in claim 5, wherein the nano-fiber supramolecular skin care composition is prepared by the following steps: 1. dissolving solid skin care active ingredient in water, organic solution or oily component to form high concentration water solution, oil solution or organic solution of active ingredient, or emulsifying fat soluble active ingredient into oil-in-water or water-in-oil emulsion, wherein liquid active ingredient can be directly used; 2. mixing nano fiber with high-concentration skin care active ingredient aqueous solution, oil solution, organic solution, emulsion or liquid active ingredient, stirring uniformly, grinding or homogenizing and emulsifying if necessary, and adsorbing the high-concentration skin care active ingredient in the pores of the three-dimensional structure of the nano fiber under the action of strong adsorption force and polar groups of the nano fiber to form the particle type multi-component composite material, namely the nano fiber supermolecule skin care composition.
7. The nano-fiber supermolecule skin care composition of claim 6, wherein the film forming agent is dissolved in water to form a gel blocking agent, then the gel blocking agent is mixed with the nano-fiber supermolecule skin care composition of claim 6, the mixture is uniformly stirred, the gel blocks the outer openings of the micropores of the nano-fibers in the nano-fiber supermolecule skin care composition to form a firm protective film on the surface of the nano-fiber supermolecule skin care composition, and the skin care active ingredients are blocked in the micropores of the nano-fibers to prevent the skin care active ingredients in the nano-fiber supermolecule skin care composition from exuding.
8. The supramolecular skin care composition as claimed in claim 7, wherein the nanofiber raw material is homogenized under high pressure by a high pressure homogenizer to expand the nanofibers, enlarge the pores of the nanofibers, increase the adsorption force of the nanofibers, and the nanofibers are dehydrated and dried under high pressure, including but not limited to spray drying, centrifugal dehydration, vacuum dehydration, filtration dehydration, and filter pressing dehydration, and the dehydrated or dried nanofibers are used to make supramolecular skin care composition.
9. The nano fiber supramolecular skin care composition as claimed in claim 8, characterized in that before the nano fiber supramolecular skin care composition is subjected to sealing protection, the nano fiber supramolecular skin care composition is subjected to vacuum deoxygenation treatment, and then the gel sealant and the nano fiber supramolecular skin care composition are uniformly mixed for sealing protection.
10. The nano-fiber supramolecular skin care composition as claimed in claims 1 to 9, wherein the nano-fiber supramolecular skin care composition is added into a cosmetic or external ointment system as a functional raw material of the cosmetic or external ointment to form the cosmetic or external ointment containing the nano-fiber supramolecular skin care composition.
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| CN117357415A (en) * | 2023-09-28 | 2024-01-09 | 宝萃生物科技有限公司 | Acne-removing composition and preparation method and application thereof |
| WO2024032549A1 (en) * | 2021-08-22 | 2024-02-15 | 张天平 | Nanofiber supramolecular skincare composition |
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|---|---|---|---|---|
| CN101214199B (en) * | 2007-12-29 | 2010-06-16 | 广东拉芳日化有限公司 | Nano active acne-eliminating cosmetic composition |
| CN105748387A (en) * | 2016-02-24 | 2016-07-13 | 义乌市巨晖生物科技有限公司 | Dairy cow hoof bath foam without antibiotics and preparation method thereof |
| CN111000751B (en) * | 2019-12-11 | 2023-05-05 | 无限极（中国）有限公司 | Solid mask and preparation method thereof |
| CN114272149A (en) * | 2021-02-02 | 2022-04-05 | 辽宁燕阳医疗设备有限公司 | Preparation method and application of dressing containing astaxanthin |
| CN114848519A (en) * | 2021-02-04 | 2022-08-05 | 张天平 | Skin tendering and acne removing lotion |
| CN115517993A (en) * | 2021-02-04 | 2022-12-27 | 张天平 | Acne-removing skin-tendering emulsion |
| CN115300412A (en) * | 2021-05-06 | 2022-11-08 | 张天平 | Fiber acne-removing lotion |
| CN115708815A (en) * | 2021-08-22 | 2023-02-24 | 张天平 | Nano-fiber supermolecule skin care composition |
-
2022
- 2022-08-11 CN CN202210960136.1A patent/CN115708815A/en active Pending
-
2023
- 2023-08-07 WO PCT/CN2023/111475 patent/WO2024032549A1/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024032549A1 (en) * | 2021-08-22 | 2024-02-15 | 张天平 | Nanofiber supramolecular skincare composition |
| CN117357415A (en) * | 2023-09-28 | 2024-01-09 | 宝萃生物科技有限公司 | Acne-removing composition and preparation method and application thereof |
| CN117357415B (en) * | 2023-09-28 | 2024-05-14 | 宝萃生物科技有限公司 | Acne-removing composition and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| WO2024032549A1 (en) | 2024-02-15 |
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