CN117338832A - Traditional Chinese medicine composition for osteoarthritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for osteoarthritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for treating osteoarthritis and a preparation method thereof, and the inventor summarizes the traditional Chinese medicine composition for treating knee osteoarthritis by combining the characteristics of dialectical treatment and overall concept of traditional Chinese medicine, and the traditional Chinese medicine composition is prepared from the following components in parts by weight: 10-14 parts of Chinese angelica, 8-12 parts of safflower, 4-6 parts of frankincense, 4-6 parts of myrrh, 8-10 parts of sappan wood, 0.2-0.4 part of borneol and 22-30 parts of linseed oil, wherein the traditional Chinese medicine composition can be directly and externally smeared according to the use method of a traditional Chinese medicine prescription, has definite curative effect and good patient adaptability according to the clinical test of the inventor, can effectively treat the joint pain problem of patients with osteoarthritis, has no toxic or side effect, and has simple process, strong operability and wide application prospect.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine composition for osteoarthritis and a preparation method thereof.
Background
Osteoarthritis (Knee Osteoarthritis, OA) is a common degenerative joint disease in the middle-aged and elderly population, and the symptoms caused by it, such as joint swelling, pain, deformity, and movement disorders, seriously affect the quality of life of the patient. According to the latest epidemiological research data and the 2018 edition of the diagnosis and treatment guide for osteoarthritis, the incidence rate of symptomatic KOA is about 8.1 percent, and obvious regional differences exist, so that the incidence rate in southwest and northwest areas is obviously higher than that in North China and eastern coastal areas, and rural areas are higher than cities. With the increasing age of the population, the incidence of the disease increases year by year, and the disease is expected to become a fourth disabling disease in 2020, and since there is no radical treatment for the disease, the conservative treatment can only temporarily relieve the symptoms of the patient and is easy to repeatedly attack.
The treatment of KOA has been a clinical problem, and the latest edition of guidelines has proposed stepped treatment concepts and strategies that would greatly improve the clinical outcome of clinicians. However, the selection of KOA conservative treatment medicines is still a challenging task in clinic, and most medicines have great toxic and side effects due to lack of specific action targets, and most patients cannot adhere to long-term and regular administration, so that the condition is continuously developed and worsened, and finally, only joint replacement with high medical cost can be performed, so that great pain and medical burden are brought to the patients. The new edition of guidelines increases the application of Chinese patent medicines for treating KOA for the first time, and the Chinese patent medicines are considered to be capable of effectively relieving the symptoms of patients through various ways, but the action mechanism and the long-term curative effect are not clear yet.
The internal medicine for treating knee osteoarthritis has clear mechanism of action and definite curative effect, but side effects are easy to occur in clinic, and symptoms are easy to repeat. The effect of the operation treatment is quick, but the joint movement disorder of the patient after the operation is still avoided.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for osteoarthritis and a preparation method thereof, so as to solve the technical problems of how to effectively improve the side effects which are easy to occur in clinic, the symptoms are easy to repeat, the joint movement disorder of a patient after operation and the like through a traditional Chinese medicine formula.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for osteoarthritis, which is prepared from the following components in parts by weight: 10 to 14 parts of angelica, 8 to 12 parts of safflower, 4 to 6 parts of frankincense, 4 to 6 parts of myrrh, 8 to 10 parts of sappan wood, 0.2 to 0.4 part of borneol and 22 to 30 parts of linseed oil.
Preferably, the composition is prepared from the following components in parts by weight: 12 parts of Chinese angelica, 10 parts of safflower, 5 parts of frankincense, 5 parts of myrrh, 9 parts of sappan wood, 0.3 part of borneol and 26 parts of linseed oil.
The invention also provides a preparation method of the traditional Chinese medicine composition for osteoarthritis, which comprises the following steps:
1) Mixing radix Angelicae sinensis, carthami flos, olibanum, myrrha, lignum sappan and Borneolum Syntheticum to obtain a mixture;
2) Grinding and sieving the mixed material to obtain undersize;
3) Heating linseed oil, adding the heated linseed oil into the undersize obtained in the step 2), and stirring to obtain the traditional Chinese medicine composition for osteoarthritis.
Preferably, the rotational speed of the polishing in the step 2) is 2200 to 2600 rpm.
Preferably, the grinding time in the step 2) is 2 to 4 minutes.
Preferably, the number of the sieves in the step 2) is 280-320 meshes, and the number of the sieves is 2.
Preferably, the heating temperature in the step 3) is 58-62 ℃.
The inventor of the invention has summarized a traditional Chinese medicine composition (Liusheng pain-relieving paste) for treating knee osteoarthritis through long-term clinical practice and combining the characteristics of dialectical treatment and overall concept of traditional Chinese medicine, can be directly and externally applied according to the using method of a traditional Chinese medicine prescription, and has definite curative effect and good patient adaptability according to the clinical test of the inventor. Specifically, the invention provides a traditional Chinese medicine composition for treating knee osteoarthritis, which is prepared from the following raw materials:
chinese angelica root: (Latin: ANGELICA SINENSIS, part: dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae), processing method comprises removing fibrous root and silt, slightly evaporating water, bundling into small bundles, placing in a shed, slowly smoking with smoke and fire, slicing, and baking with raw or wine) as principal drug, and having sweet, pungent and warm taste; replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation. The description of Ben Cao gang mu: "treating headache, pain in heart and abdomen, moistening intestine and stomach, tendons and bones, skin, treating carbuncle, expelling pus, relieving pain, and nourishing blood. "
Safflower: (Latin: CARTHAMUS TINCTORIUS L.) the product is dried flower of Compositae plant safflower Carthamus tinctorius L. Summer flower is picked when yellow turns red, and dried in the shade or sun-dried, the processing method is that the product is slightly fragrant in smell and slightly bitter in taste, red yellow in color and bright in color and soft in texture, and is used for life.) is used as ministerial drug, pungent and warm; promoting blood circulation, dredging channels, removing blood stasis and relieving pain.
Mastic gum: (Latin: boswellia SACRA, part: boswellia Boswellia carterii Birdw of Oleraceae and Boswellia bhawdajian birdw. Bark exudation resin of the same genus of Boswellia), processing method comprises sequentially cutting bark of trunk from bottom to top, exuding resin, solidifying into solid after several days, and collecting, processing method comprises crushing, parching for oral administration, and processing with pungent, bitter and warm. Promoting blood circulation, relieving pain, detumescence and promoting granulation. The "materia medica summary" describes: boswellia is also indicated for activating blood, dispelling wind, relaxing tendons and relieving pain. … … it is also used for traumatic injury, fracture of tendons and bones, and puerperal qi and blood attack of thorns, heart and abdomen pain. "
Myrrh: (Latin: COMMIPHORA MYRRHA, part: dried resin of the olive plant Euphorbia Ding Shu Commiphora myrrha Engl. Or Hadi Ding Shu Comniphora molmol Engl. The processing method comprises collecting oleoresin exuded from bark crack into reddish brown lump in air, removing impurities, crushing, and vinegar-processing) as ministerial drug, pungent, bitter, and flat; removing blood stasis, relieving pain, detumescence and promoting granulation. Medical entry records: the medicine is new, so it can break blood, alleviate swelling and relieve pain, and is a sore-relieving medicine. "
Sappan wood: (Latin: CAESALPINIA SAPPAN, part: dried core of lignum sappan Caesalpinia sappan L of Leguminosae), processing method comprises removing white edge material, drying, sawing into segments of about 3cm, splitting into pieces or grinding into coarse powder, and making into tablet; promoting blood circulation, removing blood stasis, and relieving swelling and pain. The "Rihua Zi Ben Cao" describes: pus discharge, pain relief, carbuncle and swelling elimination and blood stasis compensation. "
Borneol: (Latin: dryobalanops aromatica Gaertn.f. the part is processed product of resin of borneol Dryobalanops aromatica Gaertn.f. of borneol family, or the trunk and branch of borneol tree are cut up, distilled and cooled to obtain crystal, and the processing method is grinding powder) is used as the drug for treating pungent, bitter and slightly cold; inducing resuscitation and refreshing mind, and clearing heat and relieving pain. Medical compilation records: borneol is used for dispelling stagnated fire, and can be used for treating convulsion, phlegm-fan, pharyngitis, tongue distention, toothache, deafness … …, which is easy to be exhausted, and is also the final yin-cold. "
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine composition for external use for improving the clinical symptoms of the knee osteoarthritis patients is summarized in long-term clinical practice, can be directly and externally applied according to the using method of a traditional Chinese medicine prescription, and has definite curative effect and good patient adaptability according to the clinical test of the inventor.
Detailed Description
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
A preparation and application method of a traditional Chinese medicine composition for osteoarthritis comprises the following steps:
1. the formula comprises the following components: 100g of Chinese angelica, 80g of safflower, 40g of frankincense, 40g of myrrh, 80g of sappan wood and 2g of borneol.
2. The preparation method comprises the following steps:
(2) Mixing all the above materials uniformly, grinding for 4 min with a Zhihao traditional Chinese medicine pulverizer at 2200 rpm;
(3) Grinding uniformly, sieving with 280 mesh sieve for 2 times, and removing residues;
(4) Heating 220g of linseed oil to 58 ℃, pouring 342g of raw material into the linseed oil, and stirring the mixture to form paste to obtain the Liusheng pain-relieving paste;
(5) Is filled into a dry sterilization container.
3. The using method comprises the following steps:
(1) Body position selection: when the liusheng pain-relieving ointment is applied, the affected part is fully exposed, and proper body positions are adopted, so that the medicine can be fixed and held stably.
(2) Preparation of local skin: the topical medicine is conventionally sterilized because skin is irritated by the medicine to generate redness, blisters and breakage, and infection is easy to occur. Before application, the part is usually washed with warm water and then application is started.
(3) Fixing the medicine: in order to ensure the exertion of the curative effect of the medicine, the applied medicine is fixed to prevent the medicine from moving or falling off. The fixing method comprises covering gauze or oilpaper thereon, and fixing with adhesive tape.
(4) The smearing time is as follows: the application time of the LIUSHENGQUTONG ointment is 6 hours, and the application time of the LIUSHENGQUTONG ointment for the elderly, children and people with weak constitution can be shortened properly. Skin allergies occur during which the intolerable itching and pain sensations should terminate immediately.
(5) The smearing mode is as follows: the LIUSHENGQUTONG ointment is applied to the affected part with a coating area of 1cm and thickness of the ointment, and is applied once daily.
Example 2
A preparation and application method of a traditional Chinese medicine composition for osteoarthritis comprises the following steps:
1. the formula comprises the following components: 140g of Chinese angelica, 120g of safflower, 60g of frankincense, 60g of myrrh, 100g of sappan wood and 4g of borneol.
2. The preparation method comprises the following steps:
(1) Mixing all the above materials uniformly, grinding for 2 min with a Zhihao traditional Chinese medicine grinder at 2600 rpm;
(3) Grinding uniformly, sieving with 320 mesh sieve for 2 times, and removing residues;
(4) Heating 300g of linseed oil to 62 ℃, pouring 484g of raw material into the linseed oil, and stirring the mixture to form paste to obtain the Liusheng pain-relieving paste;
(5) Is filled into a drying and sterilizing container
3. The using method comprises the following steps:
(1) Body position selection: when the liusheng pain-relieving ointment is applied, the affected part is fully exposed, and proper body positions are adopted, so that the medicine can be fixed and held stably.
(2) Preparation of local skin: the topical medicine is conventionally sterilized because skin is irritated by the medicine to generate redness, blisters and breakage, and infection is easy to occur. Before application, the application was started after local disinfection with 75% ethanol cotton balls.
(3) Fixing the medicine: in order to ensure the exertion of the curative effect of the medicine, the applied medicine is fixed to prevent the medicine from moving or falling off. The fixing method comprises covering gauze or oilpaper thereon, and fixing with adhesive tape.
(4) The smearing time is as follows: the application time of the LIUSHENGQUTONG ointment is 4 hours, and the application time of the LIUSHENGQUTONG ointment for the elderly, children and people with weak constitution can be shortened properly. Skin allergies occur during which the intolerable itching and pain sensations should terminate immediately.
(5) The smearing mode is as follows: the LIUSHENGQUTONG ointment is applied to the affected part with a coating area of 1cm and thickness of the ointment, and is applied once daily.
Example 3
A preparation and application method of a traditional Chinese medicine composition for osteoarthritis comprises the following steps:
1. the formula comprises the following components: 120g of Chinese angelica, 100g of safflower, 50g of frankincense, 50g of myrrh, 90g of sappan wood and 3g of borneol.
2. The preparation method comprises the following steps:
(1) Mixing all the above materials uniformly, grinding for 3 min with a Zhihao traditional Chinese medicine pulverizer at 2500 rpm;
(3) Grinding uniformly, sieving with 300 mesh sieve for 2 times, and removing residues;
(4) Heating 260g of linseed oil to 60 ℃, pouring 413g of raw material, and stirring to paste to obtain the Liusheng pain-relieving paste;
(5) Is filled into a drying and sterilizing container
The method of use is the same as in example 2.
Application example 1
Specific cases:
pan Mou, female, case number: XXX782, 68 years old.
Complaints: pain in both knees is accompanied by a 3-year impairment of activity, with a 2-month exacerbation of the left knee.
The current medical history: the patient has the hidden pain of the knee joints after tired 3 years ago, and the joint movement is bent, stretched and less favorable, especially when going up and down stairs, the patient has difficulty in squatting, the patient does not pay attention at the moment, and the symptoms after self rest and physiotherapy are relieved. The patient's subjective symptoms of knee joint pain repeatedly break out for 3 years later, and the patient does not go through the system for diagnosis and treatment every time he walks too long and aggravates after tiredness. Patients feel severe left knee joint pain before 2 months, with limited joint movement, and in order to further treat the patients in the future, the patients come to the hospital and go out to the clinic: "double knee osteoarthritis" is a diagnosis of the harvest of I'm family. The admission symptoms are as follows: the patient is conscious and has low spirit and vibration; the pain of the knee joint is fixed, the pain is very strong at night, the waist and the spine are weak, the joint movement is limited, especially when the knee joint goes up and down stairs and squats up, the weight is difficult to bear for a long time; night sleep is bad, and the patient can eat and regulate the convenience.
Special examination: the morphology of the knee joint is approximately normal, no obvious swelling exists, the gap inside the joint and the patellofemoral joint are pressed, and the function activity degree of the knee joint is: bending 120 degrees, stretching 0 degree, rotating 0 degree; a patella floating test (-), a patella pushing test (+), a drawer test (-), a Lachmann test (-), a lateral stress test (-), a convolution compression test (+), a McAb, (+), and an axial displacement test (-).
Western diagnosis: osteoarthritis of the knee
The syndrome differentiation of traditional Chinese medicine: knee arthralgia-deficiency of liver and kidney
The treatment method comprises the following steps: after the medicine of the embodiment 3 of the invention is used for treating for 1 month, the symptoms of knee joint pain are obviously relieved, and no recurrence is seen at follow-up. In order to ensure the privacy of patients, the identity of the patients is not published, and the identity information and case numbers of the patients are archived in the traditional Chinese medicine hospitals of the Uygur autonomous region in Xinjiang for review.
Application example 2
Specific cases:
wheat, man, medical records: XXX946, 52 years old.
Complaints: bilateral knee pain discomfort was associated with more than 1 year of restricted activity, aggravated for 1 week.
The current medical history: the patient has the hidden pain of the knee joints after tired 1 year later, and the joint movement is bent, stretched and less favorable, especially when going up and down stairs, the patient has difficulty in squatting, the patient does not pay attention at the moment, and the symptoms after self rest and physiotherapy are relieved. Patients with subjective symptoms of knee joint pain repeatedly attack after 1 year, and aggravate after long walking and tiredness, the patients do not make systematic diagnoses. Patients with increased pain in the knee joint with limited joint movement in 1 week had to go to our hospital before further systemic treatment, and outpatient service had been: "double knee osteoarthritis" is a diagnosis of the harvest of I'm family. The admission symptoms are as follows: the patient is conscious and has low spirit and vibration; the pain of the knee joint is fixed, the pain is very strong at night, the waist and the spine are weak, the joint movement is limited, especially when the knee joint goes up and down stairs and squats up, the weight is difficult to bear for a long time; night sleep is bad, and the patient can eat and regulate the convenience.
Special examination: the morphology of the knee joint is approximately normal, no obvious swelling exists, the gap inside the joint and the patellofemoral joint are pressed, and the function activity degree of the knee joint is: bending 120 degrees, stretching 0 degree, rotating 0 degree; a patella floating test (-), a patella pushing test (+), a drawer test (-), a Lachmann test (-), a lateral stress test (-), a convolution compression test (+), a McAb, (+), and an axial displacement test (-).
Western diagnosis: bilateral knee osteoarthritis
The syndrome differentiation of traditional Chinese medicine: knee arthralgia-deficiency of liver and kidney
The treatment method comprises the following steps: after the medicine obtained in the example 3 of the invention is used for treating for 1 month, the symptoms of knee joint pain are obviously relieved, and no recurrence is seen at follow-up. In order to ensure the privacy of patients, the identity of the patients is not published, and the identity information and case numbers of the patients are archived in the traditional Chinese medicine hospitals of the Uygur autonomous region in Xinjiang for review.
Application example 3
Specific cases:
li Mou, female, case number: XXX722, 71 years old.
Complaints: pain in both knees is accompanied by less than 4 years of activity, and the right knee is aggravated for 2 months.
The current medical history: the patient has the hidden pain of the knee joints after tired 4 years ago, and the joint movement is bent, stretched and less favorable, especially when going up and down stairs, the patient has difficulty in squatting, the patient does not pay attention at the moment, and the symptoms after self rest and physiotherapy are relieved. Patients with subjective symptoms of knee joint pain repeatedly attack after 4 years later, and aggravate after long walking and tiredness, the patients do not make systematic diagnoses. The patient had severe pain in the right knee joint 2 months ago, and joint movement was limited to the future, i.e. the patient had a doctor before further systemic treatment, and the clinic had: "double knee osteoarthritis" is a diagnosis of the harvest of I'm family. The admission symptoms are as follows: the patient is conscious and has low spirit and vibration; the pain of the knee joint is fixed, the pain is very strong at night, the waist and the spine are weak, the joint movement is limited, especially, the pain is obvious when the user goes up and down stairs and squats, the user is difficult to bear load and walk for a long time, and the user can eat the food, and can regulate the two things.
Special examination: the morphology of the knee joint is approximately normal, no obvious swelling exists, the gap inside the joint and the patellofemoral joint are pressed, and the function activity degree of the knee joint is: bending 120 degrees, stretching 0 degree, rotating 0 degree; a patella floating test (-), a patella pushing test (+), a drawer test (-), a Lachmann test (-), a lateral stress test (-), a convolution compression test (+), a McAb, (+), and an axial displacement test (-).
Western diagnosis: bilateral knee osteoarthritis
The syndrome differentiation of traditional Chinese medicine: knee arthralgia-deficiency of liver and kidney
The treatment method comprises the following steps: after the medicine obtained in the example 3 of the invention is used for treating for 1 month, the symptoms of knee joint pain are obviously relieved, and no recurrence is seen at follow-up. In order to ensure the privacy of patients, the identity of the patients is not published, and the identity information and case numbers of the patients are archived in the traditional Chinese medicine hospitals of the Uygur autonomous region in Xinjiang for review.
Application example 4
Specific cases:
a certain, female, case number: XXX967, 71 years old.
Complaints: pain in both knees is accompanied by less than 10 years of activity, and the right knee is aggravated for 5 months.
The current medical history: the patient has the hidden pain of the knee joints after fatigue 10 years ago, and the joint movement is bent, stretched and less favorable, especially when going up and down stairs, the patient has obvious difficulty in squatting, the patient does not pay attention at the moment, and the symptoms after self rest and physiotherapy are relieved. Patients with subjective symptoms of knee joint pain repeatedly attack 10 years later, and are aggravated after walking for a long time and after tiredness, and do not go to systematic diagnosis and treatment. Patients feel severe left knee joint pain before 5 months, with limited joint movement, and for further systematic treatment, patients come to visit the hospital and outpatient service are: "double knee osteoarthritis" is a diagnosis of the harvest of I'm family. The admission symptoms are as follows: the patient is conscious and has low spirit and vibration; the pain of the knee joint is fixed, the pain is very strong at night, the waist and the spine are weak, the joint movement is limited, especially when the knee joint goes up and down stairs and squats up, the weight is difficult to bear for a long time; night sleep is bad, and the patient can eat and regulate the convenience.
Special examination: the morphology of the knee joint is approximately normal, no obvious swelling exists, the gap inside the joint and the patellofemoral joint are pressed, and the function activity degree of the knee joint is: bending 120 degrees, stretching 0 degree, rotating 0 degree; a patella floating test (-), a patella pushing test (+), a drawer test (-), a Lachmann test (-), a lateral stress test (-), a convolution compression test (+), a McAb, (+), and an axial displacement test (-).
Western diagnosis: osteoarthritis of the knee
The syndrome differentiation of traditional Chinese medicine: knee arthralgia-deficiency of liver and kidney
The treatment method comprises the following steps: after the medicine obtained in the example 3 of the invention is used for treating for 1 month, the symptoms of knee joint pain are obviously relieved, and no recurrence is seen at follow-up. In order to ensure the privacy of patients, the identity of the patients is not published, and the identity information and case numbers of the patients are archived in the traditional Chinese medicine hospitals of the Uygur autonomous region in Xinjiang for review.
Experimental example 1 clinical test of the efficacy of the Chinese medicinal composition of the invention
To demonstrate the effect of the present invention on improving inflammatory conditions of the osteoarthritis, the present invention was tested for the following efficacy.
1. Test basic design
66 patients with osteoarthritis were observed, 33 in treatment group, 6 men, 33 women, and the course of disease was on average 3 years; the control group 33 people, 9 men and 24 women, age 40-89 years, and disease course 1-10 years.
The diagnosis standard refers to the NICE guide of 2022 (diagnosis and management of osteoarthritis (NG.226) for people over 16 years old), the curative effect evaluation refers to the traditional Chinese medicine disease diagnosis curative effect standard of 2019 (traditional Chinese medicine disease diagnosis curative effect standard), the test is carried out in the traditional Chinese medicine hospitals (such as third class A hospitals) in the Uygur autonomous region in Xinjiang, in order to ensure the privacy of patients, the identity of the patients is not published here, and the identity information and case number of the patients are archived in the archive room of the traditional Chinese medicine hospitals in the Uygur autonomous region in Xinjiang and can be referred to.
2. Osteoarthritis diagnosis criteria and efficacy evaluation criteria
2.1 diagnostic criteria reference 2022 NICE guide "diagnosis and management of osteoarthritis in people older than 16 years (NG.226)":
(1) 1 or several joints have continuous use-related joint pain;
(2) Age equal to or greater than 45 years old;
(3) The morning stiffness is less than or equal to 30 minutes.
2.2 efficacy evaluation criteria reference 2019 "diagnosis efficacy criteria for traditional Chinese medical Condition":
and (3) curing: swelling pain disappears, knee joint moves normally, walking squatting is painless, and recurrence is avoided. Improvement: the swelling and pain are relieved, pain still exists after the overfatigue, and the knee joint moves basically normally. The method is characterized in that: swelling repeatedly occurs, and knee pain is not relieved.
3. Treatment regimen
Treatment group: the medicine obtained in the example 3 is applied to treatment, and the treatment time is 10-12 days per person;
control group: conventional hyperthermia (acupoint application therapy) is used;
4. statistical methods:
SPSS26.0 was used for data processing and statistical analysis. The counting data is checked by a chi-square, whether the counting data is normally distributed is checked by a normal test, if the data among groups accords with the normal distribution, the counting data is checked by two independent samples t-test, and whether the probability P value is smaller than 0.05 is analyzed to be statistically significant.
5. Results
5.1 general data
According to the planned study protocol, the treatment group was 33 persons, 6 men, 27 women, 33 persons in the control group, 9 men, 24 women.
After statistical treatment and analysis, the chi-square test result is: 0.387, suggesting that the treatment group and the control group patients have no statistical significance in the difference of gender conditions, the age is subject to t-test of two independent samples, t=1.353, corresponding to p=0.181, and the treatment group and the control group have no statistical significance in the difference of age conditions; the VAS score was t-tested on two independent samples, pre-treatment versus post-treatment for treatment group, t= 3.349, corresponding to p=0.001, pre-treatment versus post-treatment for control group, t= 2.181, corresponding to p=0.033, suggesting that the difference in VAS scores between pre-treatment and post-treatment for treatment group versus control group is statistically significant, as shown in tables 1, 2, and 3.
Table 1 sex comparison of the treated group with the control group
Table 2 age comparison of treatment group and control group
Table 3 comparison of the VAS scores for the treated and control groups
As can be seen from the contents of table 3, the treatment group VAS score decreased by 1.63, and the control group VAS score decreased by 1.00. The VAS score of the treatment group was significantly reduced relative to the control group. Therefore, the traditional Chinese medicine composition for osteoarthritis obtained by the method has excellent technical effect of treating osteoarthritis.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.
Claims (7)
1. The traditional Chinese medicine composition for osteoarthritis is characterized by being prepared from the following components in parts by weight: 10 to 14 parts of angelica, 8 to 12 parts of safflower, 4 to 6 parts of frankincense, 4 to 6 parts of myrrh, 8 to 10 parts of sappan wood, 0.2 to 0.4 part of borneol and 22 to 30 parts of linseed oil.
2. The traditional Chinese medicine composition for osteoarthritis as claimed in claim 1, which is characterized by being prepared from the following components in parts by weight: 12 parts of Chinese angelica, 10 parts of safflower, 5 parts of frankincense, 5 parts of myrrh, 9 parts of sappan wood, 0.3 part of borneol and 26 parts of linseed oil.
3. The method for preparing a traditional Chinese medicine composition for osteoarthritis as claimed in claim 1 or 2, comprising the following steps:
1) Mixing radix Angelicae sinensis, carthami flos, olibanum, myrrha, lignum sappan and Borneolum Syntheticum to obtain a mixture;
2) Grinding and sieving the mixed material to obtain undersize;
3) Heating linseed oil, adding the heated linseed oil into the undersize obtained in the step 2), and stirring to obtain the traditional Chinese medicine composition for osteoarthritis.
4. The method for preparing a Chinese medicinal composition for osteoarthritis as claimed in claim 3, wherein the rotational speed of grinding in the step 2) is 2200 to 2600 rpm.
5. The method for preparing a Chinese medicinal composition for osteoarthritis as claimed in claim 3, wherein the grinding time in the step 2) is 2 to 4 minutes.
6. The method for preparing a Chinese medicinal composition for osteoarthritis as claimed in claim 3, wherein the number of the sieves in the step 2) is 280-320 meshes, and the number of the sieves is 2.
7. The method for preparing a Chinese medicinal composition for osteoarthritis as claimed in claim 3, wherein the heating temperature in the step 3) is 58-62 ℃.
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