CN117159571A - 用于抵抗蒽环类诱导的心脏毒性的药物组合物和用途 - Google Patents

用于抵抗蒽环类诱导的心脏毒性的药物组合物和用途 Download PDF

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Publication number
CN117159571A
CN117159571A CN202310925308.6A CN202310925308A CN117159571A CN 117159571 A CN117159571 A CN 117159571A CN 202310925308 A CN202310925308 A CN 202310925308A CN 117159571 A CN117159571 A CN 117159571A
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Prior art keywords
cancer
agent
myricetin
protective agent
pharmaceutical composition
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Pending
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CN202310925308.6A
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English (en)
Chinese (zh)
Inventor
C·G·阿姆斯壮
K·J·金
L·M·L·帕姆
E·帕克
Z·钟
G·黄
J·C·吴
S·P·埃尔默
V·维苏蒂卡莱西
E·M·G·卡达格
T·B·弗瑞曼
P·Y·鲁姆
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Aorunsha Co ltd
Sct Second Generation Co ltd
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Aorunsha Co ltd
Sct Second Generation Co ltd
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Application filed by Aorunsha Co ltd, Sct Second Generation Co ltd filed Critical Aorunsha Co ltd
Publication of CN117159571A publication Critical patent/CN117159571A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
CN202310925308.6A 2016-02-04 2017-02-03 用于抵抗蒽环类诱导的心脏毒性的药物组合物和用途 Pending CN117159571A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662291480P 2016-02-04 2016-02-04
US62/291,480 2016-02-04
US201662348102P 2016-06-09 2016-06-09
US62/348,102 2016-06-09
CN201780009774.2A CN108697646A (zh) 2016-02-04 2017-02-03 用于抵抗化学疗法诱导的心脏毒性的药物组合物和方法
PCT/US2017/016582 WO2017136774A1 (en) 2016-02-04 2017-02-03 Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity

Related Parent Applications (1)

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CN201780009774.2A Division CN108697646A (zh) 2016-02-04 2017-02-03 用于抵抗化学疗法诱导的心脏毒性的药物组合物和方法

Publications (1)

Publication Number Publication Date
CN117159571A true CN117159571A (zh) 2023-12-05

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Family Applications (4)

Application Number Title Priority Date Filing Date
CN202310925303.3A Pending CN117045793A (zh) 2016-02-04 2017-02-03 具有降低的心脏毒性的抗癌药物组合物及用途
CN202310925314.1A Pending CN117100734A (zh) 2016-02-04 2017-02-03 一种拓扑异构酶ii抑制剂及其用途和药物组合物
CN201780009774.2A Pending CN108697646A (zh) 2016-02-04 2017-02-03 用于抵抗化学疗法诱导的心脏毒性的药物组合物和方法
CN202310925308.6A Pending CN117159571A (zh) 2016-02-04 2017-02-03 用于抵抗蒽环类诱导的心脏毒性的药物组合物和用途

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CN202310925303.3A Pending CN117045793A (zh) 2016-02-04 2017-02-03 具有降低的心脏毒性的抗癌药物组合物及用途
CN202310925314.1A Pending CN117100734A (zh) 2016-02-04 2017-02-03 一种拓扑异构酶ii抑制剂及其用途和药物组合物
CN201780009774.2A Pending CN108697646A (zh) 2016-02-04 2017-02-03 用于抵抗化学疗法诱导的心脏毒性的药物组合物和方法

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US (5) US10806716B2 (enExample)
EP (1) EP3411017A4 (enExample)
JP (2) JP7058396B2 (enExample)
KR (1) KR20180116298A (enExample)
CN (4) CN117045793A (enExample)
AU (1) AU2017214668B2 (enExample)
CA (1) CA3013768A1 (enExample)
CO (1) CO2018009132A2 (enExample)
HK (1) HK1257954A1 (enExample)
IL (2) IL284341B2 (enExample)
MX (4) MX2018009338A (enExample)
MY (1) MY197069A (enExample)
NZ (1) NZ745881A (enExample)
PH (1) PH12018501387A1 (enExample)
RU (2) RU2021103727A (enExample)
SG (1) SG11201805375PA (enExample)
WO (1) WO2017136774A1 (enExample)
ZA (1) ZA201805741B (enExample)

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EP3464275B1 (en) 2016-05-26 2024-05-08 Recurium IP Holdings, LLC Egfr inhibitor compounds
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
US11890292B2 (en) 2017-02-27 2024-02-06 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
WO2018170457A1 (en) 2017-03-17 2018-09-20 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
US12213958B2 (en) 2017-11-17 2025-02-04 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
AU2019261329B2 (en) * 2018-04-23 2024-09-05 Inspirmed Corp. Inhalable liposomal sustained release composition for use in treating pulmonary diseases
PL429672A1 (pl) * 2019-04-17 2020-10-19 Bioxan Spółka Z Ograniczoną Odpowiedzialnością Preparat zawierający ksantohumol i zastosowanie ksantohumolu
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