MY197069A - Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity - Google Patents

Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity

Info

Publication number
MY197069A
MY197069A MYPI2018702719A MYPI2018702719A MY197069A MY 197069 A MY197069 A MY 197069A MY PI2018702719 A MYPI2018702719 A MY PI2018702719A MY PI2018702719 A MYPI2018702719 A MY PI2018702719A MY 197069 A MY197069 A MY 197069A
Authority
MY
Malaysia
Prior art keywords
methods
protective agent
pharmaceutical compositions
cardiotoxicity
treatment
Prior art date
Application number
MYPI2018702719A
Other languages
English (en)
Inventor
G Armstrong Christopher
J Kim Kevin
Maria Lucia Pham Lisa
Park Eunhye
Zhong Zhong
Huang Guanyi
C Wu Joseph
Paul Elmer Sidney
Visuthikraisee Viwat
Michael G Cadag Eithon
Bernard Freeman Thomas
Yee Lum Pek
Original Assignee
Sct Ii Llc
Auransa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59496710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY197069(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sct Ii Llc, Auransa Inc filed Critical Sct Ii Llc
Publication of MY197069A publication Critical patent/MY197069A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
MYPI2018702719A 2016-02-04 2017-02-03 Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity MY197069A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662291480P 2016-02-04 2016-02-04
US201662348102P 2016-06-09 2016-06-09
PCT/US2017/016582 WO2017136774A1 (en) 2016-02-04 2017-02-03 Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity

Publications (1)

Publication Number Publication Date
MY197069A true MY197069A (en) 2023-05-24

Family

ID=59496710

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2018702719A MY197069A (en) 2016-02-04 2017-02-03 Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity

Country Status (18)

Country Link
US (5) US20170224654A1 (enExample)
EP (1) EP3411017A4 (enExample)
JP (2) JP7058396B2 (enExample)
KR (1) KR20180116298A (enExample)
CN (4) CN117100734A (enExample)
AU (1) AU2017214668B2 (enExample)
CA (1) CA3013768A1 (enExample)
CO (1) CO2018009132A2 (enExample)
HK (1) HK1257954A1 (enExample)
IL (2) IL284341B2 (enExample)
MX (4) MX2018009338A (enExample)
MY (1) MY197069A (enExample)
NZ (1) NZ745881A (enExample)
PH (1) PH12018501387A1 (enExample)
RU (2) RU2021103727A (enExample)
SG (1) SG11201805375PA (enExample)
WO (1) WO2017136774A1 (enExample)
ZA (1) ZA201805741B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8933078B2 (en) 2011-07-14 2015-01-13 Research Cancer Institute Of America Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances
MX2018009338A (es) 2016-02-04 2019-01-10 Stem Cell Theranostics Inc Composiciones farmaceuticas y metodos para contrarrestar la cardiotoxicidad inducida por quimioterapia.
US10513509B2 (en) 2016-05-26 2019-12-24 Recurium Ip Holdings, Llc EGFR inhibitor compounds
AU2018209164B2 (en) 2017-01-17 2021-11-04 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
WO2018157081A1 (en) 2017-02-27 2018-08-30 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
US11369585B2 (en) 2017-03-17 2022-06-28 Research Cancer Institute Of America Compositions, methods, systems and/or kits for preventing and/or treating neoplasms
EP3710434A4 (en) * 2017-11-17 2021-07-28 Research Cancer Institute of America COMPOSITIONS, METHODS, SYSTEMS AND / OR KITS FOR THE PREVENTION AND / OR TREATMENT OF NEOPLASMS
KR20210003197A (ko) * 2018-04-23 2021-01-11 티엘씨 바이오파머슈티컬즈 인코포레이티드 폐 질환 치료에 사용하기 위한 흡입 가능한 리포솜 서방형 조성물
PL429672A1 (pl) * 2019-04-17 2020-10-19 Bioxan Spółka Z Ograniczoną Odpowiedzialnością Preparat zawierający ksantohumol i zastosowanie ksantohumolu
KR102349477B1 (ko) * 2019-08-30 2022-01-10 (주)프론트바이오 바이구아나이드 계열 화합물 및 플라본, 하이드록시플라본, 플라바논, 플라본 유도체, 하이드록시플라본 유도체, 플라바논 유도체의 복합제를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물
AU2020404930A1 (en) * 2019-12-15 2022-08-04 Baruch S. Blumberg Institute Methods, kits and compositions for reducing cardiotoxicity associated with cancer therapies
CN111228271A (zh) * 2020-03-31 2020-06-05 青岛泱深生物医药有限公司 含拉帕替尼的药物组合物及其应用
CN113880897B (zh) * 2020-10-30 2023-06-02 杭州拉林智能科技有限公司 黄酮苷-有机胺类酪氨酸激酶抑制剂复盐化合物及其制备方法和应用
CN112353944A (zh) * 2020-11-23 2021-02-12 湖州师范学院求真学院 一种包括化合物f-b的抗癌联合用药组合物
CN112386704B (zh) * 2020-11-23 2023-07-04 中国科学院西北高原生物研究所 一种包括化合物f-c的抗癌联合用药组合物
CN112438977B (zh) * 2020-12-02 2023-05-19 贵州大学 一种含苯并咪唑的杨梅素衍生物、制备方法及用途
CN112870194B (zh) * 2021-01-06 2022-06-21 广州医科大学附属肿瘤医院 治疗肝癌的组合物及其应用
CN113143925B (zh) * 2021-04-16 2022-03-25 浙江大学智能创新药物研究院 盐酸二甲双胍在制备治疗克唑替尼心脏毒性制剂中的应用
CN113304275B (zh) * 2021-06-04 2023-04-11 仲恺农业工程学院 一种二氢杨梅素修饰dna药物递送系统、纳米载药系统及制备方法和应用
US11938127B2 (en) 2021-09-28 2024-03-26 Wayne State University Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders
WO2023079141A2 (en) * 2021-11-05 2023-05-11 Tienush Rassaf Amelioration and treatment of infarction damage
US20230165831A1 (en) * 2021-11-19 2023-06-01 Impact Biolife Science, Inc. Method and composition for rendering cancer cells susceptible to treatment by targeted oncogenetic drivers
CN115290608B (zh) * 2021-12-22 2024-08-13 温州医科大学 快速检测米托蒽醌或阿霉素的试剂及检测方法
US11903944B1 (en) 2023-05-30 2024-02-20 King Faisal University Experimental model using pazopanib-induced cardiotoxicity
CN116606273B (zh) * 2023-07-19 2023-09-26 云南中医药大学 具有美白作用的黄花夹竹桃黄酮的制备方法
WO2025117853A1 (en) * 2023-11-29 2025-06-05 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods to ameliorate drug-induced long qt syndrome
CN117958187A (zh) * 2024-01-10 2024-05-03 青岛大学 阿霉素和拉帕替尼在构建斑马鱼心脏毒性损伤模型中的应用及药物筛选方法
CN119499237A (zh) * 2024-12-10 2025-02-25 阜外华中心血管病医院 羟基芫花素在制备防治抗肿瘤药物诱导的心脏毒性的药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214308A2 (en) * 1999-09-23 2002-06-19 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Novel flavonoids
AU2001255696A1 (en) * 2000-04-27 2001-11-07 Geron Corporation Telomerase inhibitors and methods of their use
WO2002056823A2 (en) * 2001-01-18 2002-07-25 Arnold Hoffman Redox therapy for tumors
US20070185069A1 (en) 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
CA2755014A1 (en) 2008-03-10 2009-09-17 University Of Louisville Research Foundation, Inc. Methods and compositions for controlled delivery of phytochemical agents
MX339451B (es) * 2008-04-03 2016-05-27 Cognate 3 Llc Composiciones y metodos para inmunoterapia.
CN101485655B (zh) * 2009-02-12 2012-08-22 华南理工大学 二氢杨梅素在制备防治肿瘤放化疗不良反应的药物的应用
HUE028642T2 (en) 2009-04-20 2016-12-28 Galen Bio Inc Preparations for incorporating biomolecules into cells
CN102697795B (zh) 2011-07-01 2014-06-18 成都医学院 一种抗肿瘤联合用药物
US20150018294A1 (en) * 2012-02-07 2015-01-15 Arrigo DE BENEDETTI Modulators of tousled kinase in cellular processes
WO2014077409A1 (ja) 2012-11-19 2014-05-22 国立大学法人東京大学 スニチニブの副作用軽減剤
CN103315993A (zh) 2013-06-22 2013-09-25 浙江大学 二氢杨梅素在制备抑制阿霉素心脏毒性药物中的应用
KR20150084535A (ko) 2014-01-14 2015-07-22 건국대학교 산학협력단 피세틴의 수용성 및 생체이용률을 개선하는 조성물 및 그 방법
WO2015138186A2 (en) 2014-03-12 2015-09-17 Wake Forest University Health Sciences Methods and compositions for treating anthracycline-induced cardiomyopathy using neurokinin-1 receptor antagonists
MX2018009338A (es) 2016-02-04 2019-01-10 Stem Cell Theranostics Inc Composiciones farmaceuticas y metodos para contrarrestar la cardiotoxicidad inducida por quimioterapia.
CN107595802B (zh) 2017-09-27 2021-04-23 浙江海洋大学 杨梅素在制备抗阿霉素心脏毒性保护制剂中的应用

Also Published As

Publication number Publication date
MX2018009338A (es) 2019-01-10
US20210121436A1 (en) 2021-04-29
IL260972B (en) 2021-07-29
CA3013768A1 (en) 2017-08-10
RU2021103727A (ru) 2021-03-17
PH12018501387A1 (en) 2019-02-27
CO2018009132A2 (es) 2018-12-14
US20190175544A1 (en) 2019-06-13
EP3411017A1 (en) 2018-12-12
MX2021009540A (es) 2022-12-14
MX2022001541A (es) 2022-03-02
RU2018130330A3 (enExample) 2020-04-16
JP7058396B2 (ja) 2022-04-22
CN108697646A (zh) 2018-10-23
RU2743433C2 (ru) 2021-02-18
IL284341B1 (en) 2023-05-01
ZA201805741B (en) 2022-12-21
US10806716B2 (en) 2020-10-20
IL284341A (en) 2021-07-29
SG11201805375PA (en) 2018-07-30
AU2017214668B2 (en) 2022-12-08
CN117045793A (zh) 2023-11-14
US11166936B2 (en) 2021-11-09
CN117100734A (zh) 2023-11-24
JP2019504100A (ja) 2019-02-14
US20200253920A1 (en) 2020-08-13
JP2022017518A (ja) 2022-01-25
CN117159571A (zh) 2023-12-05
US20220133684A1 (en) 2022-05-05
HK1257954A1 (zh) 2019-11-01
US20170224654A1 (en) 2017-08-10
AU2017214668A1 (en) 2018-09-20
NZ745881A (en) 2023-04-28
US11786503B2 (en) 2023-10-17
IL284341B2 (en) 2023-09-01
MX2022001540A (es) 2022-03-02
WO2017136774A1 (en) 2017-08-10
BR112018015979A2 (pt) 2018-12-18
KR20180116298A (ko) 2018-10-24
EP3411017A4 (en) 2020-02-12
US10874633B2 (en) 2020-12-29
RU2018130330A (ru) 2020-03-05

Similar Documents

Publication Publication Date Title
PH12018501387A1 (en) Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity
SA518400356B1 (ar) مثبطات الأرجيناز واستخداماتها العلاجية
PH12019500521A1 (en) Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
MX2024004439A (es) Agentes terapeuticos para enfermedades neurodegenerativas
UA122346C2 (uk) ТЕТРАГІДРО-1H-ПІРИДО[3,4-b]ІНДОЛЬНІ АНТИЕСТРОГЕННІ ЛІКАРСЬКІ ПРЕПАРАТИ
TW201613887A (en) Antiproliferative compounds and methods of use thereof
WO2018022668A3 (en) NEUROMODULATORY COMPOSITIONS AND ASSOCIATED METHODS OF TREATING CANCER
NZ738929A (en) Methods of treating solid tumors using nanoparticle mtor inhibitor combination therapy
NZ754865A (en) Combination therapy for the treatment of cancer
PH12019502197A1 (en) Macrocyclic compound and uses thereof
EP4613333A3 (en) Pharmaceutical compositions comprising akt protein kinase inhibitors
PH12016501527B1 (en) Pharmaceutical composition comprising diamino heterocyclic carboxamide compound as active ingredient
EP4339192A3 (en) Compounds and compositions for the treatment of cancer
MX2020012989A (es) Agente terapeutico para la fibrosis.
TN2019000032A1 (en) Pharmaceutical compositions and uses directed to lysosomal storage disorders
WO2016130581A3 (en) Combination cancer therapy
WO2016127123A3 (en) Compounds and methods for preventing or treating sensory hair cell death
PH12020500510A1 (en) Prophylactic and/or therapeutic agent for diseases involving ido expression
PH12016502236A1 (en) (r)-pirlindole and its pharmaceutically acceptable salts for use in medicine
PH12018501758A1 (en) Oritavancin formulations
WO2019070709A8 (en) Compounds for treating or preventing flavivirus infections
WO2018094035A3 (en) Ligand ionophore conjugates
HK1246679A1 (zh) 丝虫病的治疗
HK1244485A1 (zh) 用於治療神經母細胞瘤的組合物
NZ764088A (en) Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan