CN116999488B - Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of sow lactation products - Google Patents
Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of sow lactation products Download PDFInfo
- Publication number
- CN116999488B CN116999488B CN202310991868.1A CN202310991868A CN116999488B CN 116999488 B CN116999488 B CN 116999488B CN 202310991868 A CN202310991868 A CN 202310991868A CN 116999488 B CN116999488 B CN 116999488B
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- sow
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000006651 lactation Effects 0.000 title abstract description 15
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 22
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 22
- 239000011669 selenium Substances 0.000 claims abstract description 22
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 14
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 14
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 14
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 14
- 244000228451 Stevia rebaudiana Species 0.000 claims abstract description 14
- 235000008434 ginseng Nutrition 0.000 claims abstract description 14
- 241000132012 Atractylodes Species 0.000 claims abstract description 13
- 235000003805 Musa ABB Group Nutrition 0.000 claims abstract description 13
- 240000008790 Musa x paradisiaca Species 0.000 claims abstract description 13
- 235000015266 Plantago major Nutrition 0.000 claims abstract description 13
- 235000006092 Stevia rebaudiana Nutrition 0.000 claims abstract description 13
- 240000007890 Leonurus cardiaca Species 0.000 claims abstract description 5
- 241000208340 Araliaceae Species 0.000 claims description 13
- 239000000284 extract Substances 0.000 claims description 12
- 241000112528 Ligusticum striatum Species 0.000 claims description 9
- 244000197580 Poria cocos Species 0.000 claims description 9
- 235000008599 Poria cocos Nutrition 0.000 claims description 9
- 241000007126 Codonopsis pilosula Species 0.000 claims description 7
- 239000003674 animal food additive Substances 0.000 claims description 7
- 235000006533 astragalus Nutrition 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 241000045403 Astragalus propinquus Species 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 235000012239 silicon dioxide Nutrition 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 239000000273 veterinary drug Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 230000012173 estrus Effects 0.000 abstract description 27
- 235000013336 milk Nutrition 0.000 abstract description 12
- 239000008267 milk Substances 0.000 abstract description 12
- 210000004080 milk Anatomy 0.000 abstract description 12
- 229940107666 astragalus root Drugs 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 6
- 241000212322 Levisticum officinale Species 0.000 abstract description 5
- 239000001645 levisticum officinale Substances 0.000 abstract description 5
- 230000012010 growth Effects 0.000 abstract description 4
- 235000019629 palatability Nutrition 0.000 abstract description 3
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 25
- 238000012360 testing method Methods 0.000 description 24
- 210000000952 spleen Anatomy 0.000 description 23
- 230000000694 effects Effects 0.000 description 17
- 230000007812 deficiency Effects 0.000 description 11
- 230000001737 promoting effect Effects 0.000 description 11
- 235000021050 feed intake Nutrition 0.000 description 10
- 206010012735 Diarrhoea Diseases 0.000 description 9
- 241000207925 Leonurus Species 0.000 description 9
- 210000003022 colostrum Anatomy 0.000 description 9
- 235000021277 colostrum Nutrition 0.000 description 9
- 239000000796 flavoring agent Substances 0.000 description 9
- 235000019634 flavors Nutrition 0.000 description 9
- 230000010415 tropism Effects 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 230000002354 daily effect Effects 0.000 description 7
- 230000034994 death Effects 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 208000004880 Polyuria Diseases 0.000 description 6
- 230000035619 diuresis Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 102000014171 Milk Proteins Human genes 0.000 description 4
- 108010011756 Milk Proteins Proteins 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 235000021243 milk fat Nutrition 0.000 description 4
- 235000021239 milk protein Nutrition 0.000 description 4
- 238000004904 shortening Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 235000021051 daily weight gain Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 230000004584 weight gain Effects 0.000 description 3
- 241001061264 Astragalus Species 0.000 description 2
- 241000756943 Codonopsis Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000004233 talus Anatomy 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010055690 Foetal death Diseases 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008195 breast development Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 208000010515 dystocia Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000002219 extraembryonic membrane Anatomy 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000008642 heat stress Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000017971 listlessness Diseases 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000023247 mammary gland development Effects 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition, a preparation method thereof and application thereof in preparing a sow lactation product, wherein the traditional Chinese medicine composition comprises the following components: astragalus root, ginseng leaf, pilose asiabell root, stevia rebaudiana, plantain herb, szechuan lovage rhizome, acanthopanax root, motherwort herb, indian buead, largehead atractylodes rhizome and yeast selenium. The invention improves palatability, has low cost, is convenient to feed and absorb medicines, and can improve the feeding and lactation yield of the lactating sows. Meanwhile, the invention is used as a traditional Chinese veterinary medicine, can also improve the quality of the primary milk and the normal milk of the sow, improve the growth performance of piglets and promote the oestrus of the sow after weaning.
Description
Technical Field
The invention belongs to the field of veterinary medicines for livestock and poultry, and particularly relates to a traditional Chinese medicine composition, a preparation method thereof and application thereof in preparing a sow lactation product.
Background
The lactating sow has low feed intake and low lactation yield, is a common problem in pig raising in China, often causes serious weight loss in the lactating sow, prolongs the oestrus time after weaning, causes slow growth, increased diarrhea rate and increased death rate of piglets in a delivery room, seriously influences pig raising benefit, and brings great economic loss to pig raising. The feed quality and the nutrition level are generally improved for a long time in the industry, and a certain effect is achieved. However, the feed cost is increased by the nutrition means, and the problems of digestion, absorption, nutrition metabolism and the like caused by the weakness of the spleen and the stomach of the sow cannot be completely solved. Therefore, the method of invigorating qi and spleen, activating blood and dissolving stasis in traditional Chinese medicine is used for improving the postpartum sub-health of the sow, and various problems in the lactation period of the sow can be well solved. Meanwhile, the traditional Chinese medicine is green, safe, efficient, low in toxicity, free of residues and drug resistance, and is a widely accepted product in the breeding industry.
Disclosure of Invention
The invention aims to: aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition, a preparation method thereof and application thereof in preparing a sow lactation product.
In order to solve the technical problems, the invention discloses the following technical scheme:
in a first aspect, the invention discloses a traditional Chinese medicine composition, which comprises the following components: astragalus root, ginseng leaf, pilose asiabell root, stevia rebaudiana, plantain herb, szechuan lovage rhizome, acanthopanax root, motherwort herb, indian buead, largehead atractylodes rhizome and yeast selenium.
The pharmacology and medicinal properties of the traditional Chinese medicine components in the traditional Chinese medicine composition are as follows:
radix astragali: sex flavor meridian tropism: sweet and slightly warm; enter spleen and lung meridians; the main functions are as follows: tonifying qi and rising yang, strengthening exterior and stopping sweat, expelling toxin and promoting granulation, inducing diuresis and relieving swelling; can be used for treating spleen and lung qi deficiency, anorexia, and listlessness.
Ginseng leaf: sex flavor meridian tropism: sweet and slightly bitter; enter spleen, lung and heart channels; the main functions are as follows: tonifying spleen and stomach, promoting fluid production and soothing nerves; it is used for treating various deficiency syndromes and deficiency of both fluid and qi.
Radix codonopsis pilosulae: sex flavor meridian tropism: sweet and flat; enter spleen and lung meridians; the main functions are as follows: middle-jiao invigorating, qi invigorating, spleen invigorating, and salivation promoting effects; can be used for treating chronic diseases, qi deficiency, spleen deficiency, diarrhea, and short breath due to lung deficiency.
Stevia rebaudiana bertoni: feeding attraction, feed intake improvement and heat stress resistance.
Herb of plantain: sex flavor meridian tropism: sweet, light and cold; enter liver, kidney and small intestine channels; the main functions are as follows: clearing away heat and toxic materials, promoting diuresis and treating stranguria; can be used for treating damp-heat stranguria, turbid urine, jaundice, etc.
Ligusticum wallichii: sex flavor meridian tropism: pungent and warm; enter liver, gallbladder and pericardium meridian; the main functions are as follows: promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain; can be used for treating dystocia, retention of fetal membranes, rheumatalgia, etc. due to stagnation of qi and blood.
Radix Et caulis Acanthopanacis Senticosi: sex flavor meridian tropism: pungent, bitter and warm; enter spleen, kidney and heart channels; the main functions are as follows: replenishing qi to invigorate the spleen, tonifying the kidney and soothing the nerves; can be used for treating spleen and lung qi deficiency, anorexia, etc.
Motherwort: sex flavor meridian tropism: pungent, bitter and slightly cold; heart, liver and bladder channels; the main functions are as follows: promoting blood circulation, removing blood stasis, promoting diuresis, and relieving swelling, and can be used for treating puerperal blood stasis and abdominal pain.
Poria cocos: sex flavor meridian tropism: sweet, light, flat; entering spleen, stomach, heart, lung and kidney meridians; the main functions are as follows: excrete dampness and promote diuresis, invigorate spleen and tonify middle-jiao, calm heart and tranquilize mind; can be used for treating stagnation of water and dampness, spleen deficiency and dampness control.
White atractylodes rhizome: sex flavor meridian tropism: bitter, sweet, warm; spleen and stomach meridian; the main functions are as follows: invigorating spleen, replenishing qi, eliminating dampness, promoting diuresis, preventing miscarriage, and relieving sweat; can be used for treating diarrhea due to spleen deficiency, edema, fetal movement, and sweating due to deficiency.
Selenium yeast: antioxidant, free radical scavenging, and immunity enhancing effects.
The invention is prepared according to the dialectical treatment principle of the veterinarian and carries out multiple clinical practices. Astragalus root, pilose asiabell root and ginseng leaf are used as monarch drugs for tonifying qi, strengthening exterior and invigorating spleen and stomach; poria cocos and radix acanthopanacis are ministerial drugs for replenishing qi to invigorate the spleen, tonifying kidney and soothing nerves; atractylodis rhizoma and herba plantaginis can invigorate spleen, eliminate dampness, excrete dampness, induce diuresis and alleviate edema; motherwort herb and Ligusticum wallichii are used as guiding drugs for promoting blood circulation and removing blood stasis. Meanwhile, the sweet stevia is matched with the functions of inducing food to resist stress and resisting oxidization of selenium yeast to improve immunity. The formula gives consideration to various factors such as deficiency of qi and blood, stagnation of qi and blood, spleen and stomach imbalance and the like of the lactating sow, adopts various medicaments to reasonably match, and has the advantage of obviously improving the clinical effect.
Wherein the weight parts or mass of each component are as follows: 45-75 parts of astragalus membranaceus, 35-65 parts of ginseng leaves, 35-55 parts of codonopsis pilosula, 45-65 parts of stevia rebaudiana, 45-75 parts of plantain herb, 45-75 parts of ligusticum wallichii, 35-55 parts of acanthopanax, 20-40 parts of motherwort, 35-55 parts of poria cocos, 45-75 parts of bighead atractylodes rhizome and 75-105 parts of yeast selenium; preferably, the Chinese medicinal composition comprises 50-70 parts of astragalus root, 40-60 parts of ginseng leaf, 40-50 parts of radix codonopsis pilosulae, 50-60 parts of stevia rebaudiana, 50-70 parts of plantain herb, 50-70 parts of szechuan lovage rhizome, 40-50 parts of acanthopanax root, 25-35 parts of motherwort herb, 40-50 parts of Indian buead, 50-70 parts of largehead atractylodes rhizome and 80-100 parts of yeast selenium; further preferably, the composition comprises 60 parts of astragalus root, 50 parts of ginseng leaf, 45 parts of pilose asiabell root, 55 parts of stevia rebaudiana, 60 parts of plantain herb, 60 parts of szechuan lovage rhizome, 45 parts of acanthopanax, 30 parts of motherwort herb, 45 parts of Indian buead, 60 parts of largehead atractylodes rhizome and 90 parts of yeast selenium; still more preferably, the composition comprises 60g of astragalus root, 50g of ginseng leaf, 45g of pilose asiabell root, 55g of stevia rebaudiana, 60g of plantain herb, 60g of szechuan lovage rhizome, 45g of acanthopanax root, 30g of motherwort herb, 45g of Indian buead, 60g of largehead atractylodes rhizome and 90g of yeast selenium.
Wherein, the dosage form of the pharmaceutical composition is oral administration dosage form, including but not limited to oral liquid, granule, powder, pill, tablet or capsule.
Wherein, the preparation of the pharmaceutical composition takes the traditional Chinese medicine composition as an active ingredient and also comprises common auxiliary materials or auxiliary ingredients.
In a second aspect, the invention discloses a preparation method of the traditional Chinese medicine composition in the first aspect, wherein each traditional Chinese medicine component is weighed according to the formula ratio, and other components except selenium yeast are crushed and extracted to obtain an extracting solution; concentrating the obtained extract to obtain extract; mixing the obtained extract with silicon dioxide, drying, pulverizing, and mixing with yeast selenium.
Wherein the components other than selenium yeast are pulverized to a particle size of 40-80 μm, preferably 53-62 μm.
Wherein the extracted solvent is water, and preferably, the mass fraction ratio of the solvent to other components except yeast selenium is 8-12:1, and preferably 10:1.
Wherein the extraction temperature is 70-90deg.C, preferably 80deg.C; the extraction time is 1-3h, preferably 2h.
Wherein, the concentration adopts a three-effect concentrator for concentration, and the vacuum degree and the evaporation temperature of each effect are as follows: the first effect is-0.05 MPa,85 ℃; two-effect-0.07 MPa,75 ℃, three-effect-0.09 MPa,65 ℃.
Wherein the concentration is to obtain extract with relative density of 0.9-1.3, preferably 1.10.
In a third aspect, the invention discloses a product for feeding lactating sows comprising the traditional Chinese medicine composition of the first aspect.
In a fourth aspect, the invention discloses application of the traditional Chinese medicine composition in the first aspect in preparation of a product for feeding a lactating sow.
In the above third and fourth aspects:
the product has any one or more of the following functions;
i, improving the productivity of lactating sows, preferably shortening the labor, reducing dead fetus and weak baby, and improving the feed intake of lactating sows;
ii, improving oestrus effect of lactating sows, preferably improving oestrus rate and shortening oestrus interval time;
iii, improving lactation performance of lactating sows, preferably improving colostrum quality, improving normalactation quality, improving lactation yield, or any of the foregoing; the improvement in colostrum quality, improvement in normal milk quality is preferably an improvement in milk fat, milk protein, lactose, total dry matter of colostrum or normal milk, or any of the foregoing;
iv, improving the productivity of the piglets, preferably improving the growth rate of the piglets, improving the health degree of the piglets, improving the rate of raising, reducing the rate of death and panning, reducing the rate of diarrhea, or any of the foregoing.
The product comprises veterinary medicines, feed additives and feeds; wherein, when the product is feed, the composition is prepared into common dosage forms (veterinary drugs or feed additives) and then added into the feed to prepare the feed for feeding lactating sows.
Wherein, when the product is feed, the dosage of the traditional Chinese medicine composition is 2-8 kg/ton of feed, preferably 2-4 kg/ton of feed, and the lactation yield of the sow can be improved.
Wherein, when the product is veterinary medicine or feed additive, the traditional Chinese medicine composition or the veterinary medicine or feed additive is directly fed every day, and the dosage of the traditional Chinese medicine composition is 0.2-0.4g/kg body weight, preferably 0.3g/kg body weight, and the traditional Chinese medicine composition can be taken in a divided way or one time; or adding a traditional Chinese medicine composition or veterinary medicine or feed additive into the feed, wherein the mass fraction of the traditional Chinese medicine composition is 0.1-1%, preferably 0.4-0.5%; thereby improving the lactation yield of the sow, obviously shortening the sow labor, improving the feed intake and the lactation yield of the lactating sow, improving the weaning weight and the survival rate of the piglet and comprehensively improving the production performance of the lactating sow after long-term use.
The beneficial effects are that: compared with the prior art, the invention has the following advantages:
(1) The traditional Chinese medicine composition provided by the invention has the effects of tonifying qi, strengthening the exterior, strengthening the spleen, tonifying the stomach, promoting blood circulation, removing blood stasis and strengthening physique; safe, has no side effect, treats both principal and secondary aspect of disease, and has better effect than the simple improvement of the nutrition level of the lactating sow.
(2) The traditional Chinese medicine composition provided by the invention has remarkable curative effect, not only can improve lactation yield, but also can improve sow quality and improve maternal antibody level.
(3) The invention can comprehensively improve the physique of the sow and has good effects of shortening the labor and promoting the oestrus after weaning.
(4) The traditional Chinese medicine composition provided by the invention is safe, remarkable in curative effect, low in cost, good in benefit, good in palatability and convenient to use, and is used for improving lactation of sows.
(5) The traditional Chinese medicine composition provided by the invention has good palatability, a certain food calling effect and capability of obviously improving the feed intake of sows.
Drawings
The foregoing and/or other advantages of the invention will become more apparent from the following detailed description of the invention when taken in conjunction with the accompanying drawings and detailed description.
FIG. 1 is a mammary gland development of lactating sows of the test group of example 2.
Detailed Description
The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials, unless otherwise specified, are commercially available.
EXAMPLE 1 preparation of Chinese herbal Compound
The formula comprises the following components: 60kg of astragalus, 50kg of ginseng leaf, 45kg of codonopsis pilosula, 55kg of stevia rebaudiana, 60kg of plantain herb, 60kg of ligusticum wallichii, 45kg of acanthopanax, 30kg of motherwort, 45kg of poria cocos, 60kg of bighead atractylodes rhizome and 90kg of yeast selenium.
The preparation method comprises the following steps: weighing the above medicinal materials according to weight proportion, screening and cleaning; pulverizing the other materials except selenium yeast, and sieving with 30 mesh sieve; extracting by adopting a dynamic countercurrent reflux extraction method, wherein the extracting solvent is drinking water, the mass fraction ratio of the solvent to the raw materials is 10:1, the heating temperature is 80 ℃, and the extracting time is 2 hours, so as to obtain an extracting solution; concentrating the obtained extract by a three-effect concentrator, wherein the vacuum degree and evaporation temperature of each effect are as follows: the first effect is-0.05 MPa,85 ℃; two-effect-0.07 MPa,75 ℃, three-effect-0.09 MPa,65 ℃. Concentrating the liquid medicine to a relative density of 1.10 to obtain extract; adding 200kg of silicon dioxide into the obtained extract, adsorbing, adopting 80 ℃ to dry and crush the extract to pass through a 80-mesh screen, and then adding yeast selenium and mixing the extract.
EXAMPLE 2 preparation of Chinese herbal Compound
The formula comprises the following components: 45kg of astragalus membranaceus, 35kg of ginseng leaves, 35kg of codonopsis pilosula, 45kg of stevia rebaudiana, 45kg of plantain herb, 45kg of ligusticum wallichii, 35kg of acanthopanax, 20kg of motherwort, 35kg of poria cocos, 45kg of bighead atractylodes rhizome and 75kg of yeast selenium.
The preparation process is the same as in example 1.
EXAMPLE 3 preparation of Chinese herbal Compound
The formula comprises the following components: 75kg of astragalus, 65kg of ginseng leaves, 55kg of codonopsis pilosula, 65kg of stevia rebaudiana, 75kg of plantain, 75kg of ligusticum wallichii, 55kg of acanthopanax, 40kg of motherwort, 55kg of poria cocos, 75kg of bighead atractylodes rhizome and 105kg of yeast selenium.
The preparation process is the same as in example 1.
Example 4
1. Experiment design: 40 pregnant sows with good health state and consistent gestation times (age of 85-90 days of gestation) are selected, and the recommended application range (2-10 kg of feed per ton) of the product in the basic ration of the lactating sow according to the invention is set into a high-dose group (8 kg/ton), a medium-dose group (4 kg/ton), a low-dose group (2 kg/ton) and a control group (no addition), wherein 10 pregnant sows are fed all the way from 7 days of age before delivery to delivery room before mating.
Table 1 basal diet formula and nutrient levels for lactating sows
2. Measuring the index:
(1) Sow labor course: the yield of each sow was calculated and then the difference of the average yield of each group was compared. And (3) calculating the labor: only the time required from the 1 st piglet to the last 1 piglet was calculated. And counting the time of the sow labor of each group respectively.
(2) Daily weight gain of piglets: the birth weight and the weaning weight of each piglet in the 40-litter piglets are weighed, and the average daily gain of each group of piglets is calculated.
(3) Sow oestrus rate 7 days weaning: the oestrus rate of 7d after weaning was calculated for each group of sows and then compared. Oestrus rate (%) = number of oestrus sows/total number of sow that can be propagated.
(4) Interval of weaning oestrus: and counting oestrus time of each sow in each group, and calculating average oestrus intervals.
(5) Breast milk mass analysis: and collecting colostrum and normal milk (10 mL/head) of the sow respectively at 0d after delivery and 15d after delivery of the test sow, and detecting the content of milk fat, milk protein, lactose, total dry matter and other components in the colostrum and normal milk by adopting a milk analyzer.
3. The results were as follows:
(1) Production index
Table 2 shows the effect of the herbal compound on sow labor and oestrus and daily weight gain of piglets. The sow labor and oestrus intervals were significantly reduced (P <0.05 or P < 0.01) for each dose of the traditional Chinese medicine compared to the control group. In addition, the daily gain of piglets in each dosage group of the traditional Chinese medicine is obviously higher than that in a control group (P < 0.01).
Table 2 influence of the Chinese herbal compound on sow labour, oestrus and daily weight gain of piglets
Data are expressed as mean±sem with P <0.05 and P <0.01 (comparison of compound group of traditional Chinese medicine with control group)
(2) Breast milk mass analysis
The effect of the compound traditional Chinese medicine on colostrum quality is shown in Table 3. The ratio of milk protein to total dry matter in colostrum of each dosage group of traditional Chinese medicine is significantly higher than that of the control group (P < 0.01), while the milk fat and lactose content has no significant change (P > 0.01).
TABLE 3 influence of Chinese herbal Compound on quality of colostrum
Data are expressed as mean±sem with P <0.05 and P <0.01 (comparison of compound group of traditional Chinese medicine with control group)
The effect of the compound Chinese medicine on normal milk quality is shown in Table 4. Milk fat, milk protein and lactose content in normal milk of each dosage group of the traditional Chinese medicine is obviously higher than that of a control group (P <0.05 or P < 0.01); the total dry matter level in normal milk was significantly elevated in the dosing group compared to the control group (P < 0.05).
TABLE 4 influence of Chinese herbal Compound on normal milk quality
Data are expressed as mean±sem with P <0.05 and P <0.01 (comparison of compound group of traditional Chinese medicine with control group)
(4) The breast development of the lactating sow is shown in figure 1.
4. Conclusion(s)
The data show that the traditional Chinese medicine compound can shorten the sow labor, improve the sow weaning oestrus rate, shorten oestrus time, and improve the weaning weight and colostrum of piglets and normal milk quality.
Example 5
1. Experiment design: 72 multiparous sows close to the delivery period are selected according to the average birth approaching principle and are randomly divided into a control group (35) and a test group (37), wherein the test group sows are fed with 0.4wt% of basic ration of the product produced in the embodiment 1, and the basic ration formula and the nutrition level are consistent with those of the embodiment 4. The control group sow is fed with basic ration without adding traditional Chinese medicine compound. The conditions of ventilation, illumination and the like of each group are kept consistent during the test period, and the feed is fed by wet-mixed feed, and is fed for 2 times per day, and free to eat and drink water.
2. The test results are as follows:
(1) Influence of traditional Chinese medicine compound on sow feed intake and piglet weight gain
The variation of sow feed intake and piglet weight gain is shown in table 5. The average weight of the piglets in the control group for 2 days is 1.35+/-0.04 kg, the average weight of the piglets in the test group for 2 days is 1.71+/-0.05 kg, and compared with the control group, the average weight of the piglets in the test group for 2 days is obviously increased (P < 0.05). The weaning average weight of the piglets in the control group is 6.29+/-0.14 kg, the weaning average weight of the piglets in the test group is 6.79+/-0.13 kg, and compared with the control group, the weaning average weight of the piglets in the test group is obviously increased (P < 0.05). The piglets of the test group were increased without significant difference (P > 0.05) compared with the control group. The average daily gain of piglets in the control group is 0.199+/-0.03 kg, the average daily gain of piglets in the test group is 0.204+/-0.04 kg, and the average daily gain of piglets in the test group is in an increasing trend compared with the control group. The average daily feed intake of the sows in the control group of the test group and the average daily feed intake of the weaned pigs are not significantly different from the control group (P is more than 0.05).
Table 5 influence of Chinese herbal Compound on feed intake of sow and weight gain of piglet
* P <0.05 (test group compared with control group)
(2) Influence of traditional Chinese medicine compound on oestrus rate of weaned 7d sow
The effect of the compound traditional Chinese medicine on oestrus rate in 7d weaning of sows is shown in Table 6. 34 sows in the test group have oestrus within 7 days after weaning, and the oestrus rate reaches 91.89%; the control group had 29 oestrus within 7d after weaning, with an oestrus rate of 82.86%. Compared with a control group, the oestrus rate of the sows in the test group is in an increasing trend within 7 days after weaning, which suggests that the traditional Chinese medicine compound can promote oestrus of the sows after weaning.
TABLE 6 influence of Chinese herbal Compound on oestrus rate of weaned 7d sow
(3) Influence of Chinese herbal compound on health condition of piglets
Influence of the Chinese herbal compound on the health condition of piglets. As shown in Table 7, the average healthy number of the 2-day litter of piglets is 12.49+/-2.26, and the average healthy number of the 2-day litter of piglets in the test group is 11.59 +/-1.14; the average healthy number of 21-day-old piglets of the control group is 11.00+/-1.35, the average healthy number of 2-day-old litter of piglets of the test group is 11.11+/-1.15, and the average healthy number of 2-day-old litter of the test group is not significantly different from the average healthy number of 21-day-old piglets (P is more than 0.05) compared with the control group. As shown in table 8, the control group piglet raising rate, the death rate and the diarrhea rate are 87.87%, 12.13% and 7.46%, respectively, the test group piglet raising rate, the death rate and the diarrhea rate are 95.80%, 4.20% and 2.56%, respectively, the test group piglet raising rate is improved by 7.93% compared with the control group, the difference is very obvious (P < 0.05), and in addition, compared with the control group, the test group piglet death rate and the diarrhea rate are obviously reduced (P < 0.05), the above results show that the traditional Chinese medicine compound can reduce the piglet death rate and the diarrhea rate, and improve the piglet raising rate.
Table 7 Effect of the Chinese herbal Compound on average litter size of 2-day-old and 21-day-old piglets
Table 8 influence of Chinese herbal Compound on piglet growth, death and Convergence and diarrhea Rate
* P <0.05, < P <0.01 (test group compared to control group)
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (9)
1. The traditional Chinese medicine composition is characterized by comprising the following components in parts by weight: 45-75 parts of astragalus membranaceus, 35-65 parts of ginseng leaves, 35-55 parts of codonopsis pilosula, 45-65 parts of stevia rebaudiana, 45-75 parts of plantain herb, 45-75 parts of ligusticum wallichii, 35-55 parts of acanthopanax, 20-40 parts of motherwort, 35-55 parts of poria cocos, 45-75 parts of bighead atractylodes rhizome and 75-105 parts of yeast selenium.
2. The traditional Chinese medicine composition according to claim 1, wherein the components are in parts by weight: 50-70 parts of astragalus membranaceus, 40-60 parts of ginseng leaves, 40-50 parts of codonopsis pilosula, 50-60 parts of stevia rebaudiana, 50-70 parts of plantain herb, 50-70 parts of ligusticum wallichii, 40-50 parts of acanthopanax, 25-35 parts of motherwort, 40-50 parts of poria cocos, 50-70 parts of bighead atractylodes rhizome and 80-100 parts of yeast selenium.
3. The traditional Chinese medicine composition according to claim 1, wherein the components are in parts by weight: 60 parts of astragalus membranaceus, 50 parts of ginseng leaves, 45 parts of codonopsis pilosula, 55 parts of stevia rebaudiana, 60 parts of plantain herb, 60 parts of ligusticum wallichii, 45 parts of acanthopanax, 30 parts of motherwort, 45 parts of poria cocos, 60 parts of bighead atractylodes rhizome and 90 parts of yeast selenium.
4. A Chinese medicinal composition according to any one of claims 1 to 3, wherein the dosage form of the Chinese medicinal composition is an orally administered dosage form.
5. The method for preparing the traditional Chinese medicine composition according to any one of claims 1-3, characterized in that each traditional Chinese medicine component is weighed according to the formula ratio, and other components except yeast selenium are crushed and extracted to obtain an extracting solution; concentrating the obtained extract to obtain extract; mixing the obtained extract with silicon dioxide, drying, pulverizing, and mixing with yeast selenium.
6. A product for feeding a lactating sow comprising a Chinese medicinal composition according to any one of claims 1 to 3.
7. Use of a Chinese medicinal composition according to any one of claims 1-3 for the preparation of a product for feeding a lactating sow.
8. The product of claim 6, wherein the product is a veterinary drug, a feed additive or a feed.
9. The use according to claim 7, wherein the product is a veterinary drug, a feed additive or a feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310991868.1A CN116999488B (en) | 2023-08-08 | 2023-08-08 | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of sow lactation products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310991868.1A CN116999488B (en) | 2023-08-08 | 2023-08-08 | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of sow lactation products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116999488A CN116999488A (en) | 2023-11-07 |
| CN116999488B true CN116999488B (en) | 2024-01-30 |
Family
ID=88565221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310991868.1A Active CN116999488B (en) | 2023-08-08 | 2023-08-08 | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of sow lactation products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116999488B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606632A (en) * | 2009-07-07 | 2009-12-23 | 阜新红日牧业有限公司 | Health care feed for sow in perinatal period |
| CN109364123A (en) * | 2018-11-30 | 2019-02-22 | 河北征宇制药有限公司 | A kind of fermented tcm and preparation method thereof improving performance of poultry |
| CN109589359A (en) * | 2017-09-30 | 2019-04-09 | 河南牧动物药业有限公司 | A kind of Chinese medicine composition for improving sow production performance, Chinese medicine microecological preparation and preparation method thereof |
| CN112655833A (en) * | 2020-12-22 | 2021-04-16 | 清远一生自然生物研究院有限公司 | Feed additive composition for postpartum sow conservation and application thereof |
| CN113908194A (en) * | 2021-05-28 | 2022-01-11 | 四川生力源生物工程有限公司 | Traditional Chinese veterinary medicine composition for shortening sow parturition, reducing stillbirth and increasing sow postpartum food intake |
| CN115607612A (en) * | 2021-07-16 | 2023-01-17 | 邹鲁中药研究院(广州)有限公司 | Traditional Chinese medicine compound preparation for shortening sow labor process and preparation method and application thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114009608A (en) * | 2021-11-05 | 2022-02-08 | 四川农业大学 | Compound nutrient capable of repairing damaged intestinal tracts of piglets and application thereof |
-
2023
- 2023-08-08 CN CN202310991868.1A patent/CN116999488B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606632A (en) * | 2009-07-07 | 2009-12-23 | 阜新红日牧业有限公司 | Health care feed for sow in perinatal period |
| CN109589359A (en) * | 2017-09-30 | 2019-04-09 | 河南牧动物药业有限公司 | A kind of Chinese medicine composition for improving sow production performance, Chinese medicine microecological preparation and preparation method thereof |
| CN109364123A (en) * | 2018-11-30 | 2019-02-22 | 河北征宇制药有限公司 | A kind of fermented tcm and preparation method thereof improving performance of poultry |
| CN112655833A (en) * | 2020-12-22 | 2021-04-16 | 清远一生自然生物研究院有限公司 | Feed additive composition for postpartum sow conservation and application thereof |
| CN113908194A (en) * | 2021-05-28 | 2022-01-11 | 四川生力源生物工程有限公司 | Traditional Chinese veterinary medicine composition for shortening sow parturition, reducing stillbirth and increasing sow postpartum food intake |
| CN115607612A (en) * | 2021-07-16 | 2023-01-17 | 邹鲁中药研究院(广州)有限公司 | Traditional Chinese medicine compound preparation for shortening sow labor process and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中药治疗母猪产后缺乳症;王大生;中兽医学杂志(03);第15-16页 * |
| 中药治疗母猪缺乳症;张仕颖;中兽医医药杂志(06);第46页 * |
| 发酵中药渣对妊娠母猪繁殖性能、血浆生化参数和抗氧化指标的影响;王德云;动物营养学报;第29卷(第07期);第2416-2422页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116999488A (en) | 2023-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102763781B (en) | Nutrient for improving productivity of nursing sows and preparation method thereof | |
| CN102688321B (en) | Traditional Chinese medicine preparation improving health of nursing sows and piglets thereof by maternal therapy | |
| CN106266898A (en) | A kind of vital energy benefiting and the kidney invigorating, the compound preparation and preparation method thereof of defying age | |
| CN104162094A (en) | Traditional Chinese medicine composition for treating obese polycystic ovary syndrome, and medicinal preparation thereof | |
| CN111195314A (en) | Traditional Chinese medicine composition for nourishing stomach and promoting digestion and preparation method thereof | |
| CN105941917A (en) | Pig feed capable of preventing and treating dysentery and preparation method of pig feed | |
| CN102274303B (en) | Traditional Chinese medicine extract compound injection for treating yellow-white dysentery of piglets and preparation method | |
| CN111317775A (en) | Application of preparation for removing food retention and relieving cough for children in preparation of medicine for treating fever and preparation method thereof | |
| CN102626499B (en) | Traditional Chinese medicinal composition used as both food and medicine for treating porcine respiratory tract infection, and preparation method thereof | |
| CN116999488B (en) | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of sow lactation products | |
| CN108815364B (en) | Probiotic fermented traditional Chinese medicine preparation for treating constipation of pigs and preparation method thereof | |
| CN110250346A (en) | A kind of Chinese herb feed additive improving pigling immunity | |
| CN105920316B (en) | The Chinese materia medica preparation for improving milk cow immunity, preventing mastitis for milk cows | |
| CN104208524A (en) | Medicine for treating piglet dysentery | |
| CN111588801B (en) | Traditional Chinese medicine dispersible granule for preventing livestock and poultry epidemic diseases and preparation method thereof | |
| CN112293630A (en) | Plant beverage for promoting lactation and preparation method thereof | |
| CN105902760B (en) | A kind of Chinese medicine for treating rabbit stomach enteritis | |
| CN109528827B (en) | Pharmaceutical composition and preparation for promoting blood circulation, removing blood stasis and reducing blood fat and preparation method thereof | |
| CN103705835A (en) | Drug for treating cad pig and preparation method thereof | |
| CN114259540B (en) | Traditional Chinese medicine composition for treating diabetes with syndrome of deficiency of both qi and yin and preparation method and application thereof | |
| CN116392544B (en) | Traditional Chinese medicine composition for pigs and preparation method and application thereof | |
| CN111588788B (en) | Traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough and preparation method thereof | |
| CN101966268A (en) | Traditional Chinese medicinal preparation for improving pig cutability | |
| CN105617145A (en) | Traditional Chinese medicine compound microecological preparation for improving weaned lamb immunity | |
| CN114272309A (en) | Lactation-promoting and fat-reducing composition, preparation method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |