CN111588788B - Traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough and preparation method thereof Download PDF

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CN111588788B
CN111588788B CN202010591125.1A CN202010591125A CN111588788B CN 111588788 B CN111588788 B CN 111588788B CN 202010591125 A CN202010591125 A CN 202010591125A CN 111588788 B CN111588788 B CN 111588788B
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CN111588788A (en
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张贵民
范建伟
申凤霞
韩振明
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Lunan Pharmaceutical Group Corp
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Abstract

The invention provides a traditional Chinese medicine composition for treating infantile indigestion with food retention and phlegm heat cough and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, radish seed, semen lepidii, burdock, cortex mori radicis and folium eriobotryae. Pharmacodynamics and clinical tests show that the traditional Chinese medicine composition can improve the motilin content and promote the small intestine to advance; can achieve the effects of clearing heat and regulating lung, promoting digestion and relieving stasis, reducing phlegm and relieving cough and treating both principal and secondary aspect of disease for the children with the cough caused by food retention, phlegm heat, and is convenient, safe and effective to use.

Description

Traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating infantile indigestion with food retention and phlegm-heat cough and a preparation method thereof, and belongs to the field of traditional Chinese medicines.
Background
Cough is a common and frequently occurring disease of infantile lung system. Cough due to food accumulation and phlegm-heat is a more special syndrome type in children's cough, and belongs to the category of internal injury cough. Cough due to retention of food and phlegm-heat in children, or referred to as cough with retention of food and phlegm, cough with retention of food, cough with retention of food, and cough with retention of food refers to cough in children caused by retention of food in middle energizer, accumulation of food due to long-term retention of food, stagnation of food and transformation of heat, stagnated heat burning body fluids into phlegm, turbid phlegm evaporating to the lung and obstructing the airway, and affecting the function of dispersing, purifying and descending of the lung due to the fact that the viscera are tender, the shape and qi are not full, the spleen is often insufficient, the transport and transformation of the body fluid are not known to be proper, and the excessive eating is greasy and thick. The "pulse cause syndrome treatment" is recorded as: "the syndrome of cough caused by retention of food in the middle energizer, failure of transportation and transformation, formation of phlegm into fluid retention, and ascending of phlegm-fire is ". In recent years, as the dietary structure of people tends to be more eutrophic, and in addition, children like to eat rich and sweet tastes such as high sugar, high protein and high fat, the self-control ability is poor, and the diet is not known to be hungry and full, so that the cough caused by food retention and phlegm heat of children due to heat transformation caused by food retention and stagnation is frequently attacked, and the cough accounts for more than 70% of cough patients according to the incomplete statistics of related pediatric clinics. The disease is similar to the gastroesophageal reflux cough in modern medicine, the cough is aggravated after eating the cough and even eating sweet and crying, and although antibiotics or simple cough-relieving and phlegm-resolving medicines are used for treating the disease, the curative effect is poor and the disease is easy to repeat.
The traditional Chinese medicine holds that the cough caused by food retention and phlegm heat belongs to the diseases of spleen (including stomach) and lung channels. The spleen is the source of phlegm generation, and the lung is the device for storing phlegm. Food stagnation, transforming heat into fire, transforming fluid into phlegm, phlegm-heat accumulation, stagnation in lung and cough due to failure of dispersing and descending of lung. Therefore, the lung and spleen should be treated simultaneously in the treatment of the clinical symptoms, the drugs for promoting digestion and resolving food stagnation, and regulating the lung to resolve phlegm and relieve cough are applied simultaneously, so that the traditional Chinese medicine composition not only clears away the stagnated heat of the spleen and stomach and removes food stagnation, but also regulates the lung to resolve phlegm and relieve cough to treat the root cause of disease, achieves the purposes of treating the root cause of disease and treating both principal and secondary aspect of disease. At present, the traditional Chinese medicine has obvious and reliable curative effect on treating the cough caused by food stagnation and phlegm heat. Chinese patent CN1425447A discloses a Chinese medicinal composition consisting of 10 medicaments of hawthorn, areca seed, immature bitter orange, loquat leaf, snakegourd fruit, weeping forsythia, radish seed, pepperweed seed, cicada slough and platycodon root, which can clear heat, lower lung qi, eliminate stagnation and relieve cough, and is used for treating cough, exacerbation at night, wheezy phlegm in throat, abdominal distension and halitosis caused by food stagnation and phlegm-heat in the lung. The medicine names of the invention are children food retention removing and cough stopping oral liquid (approved document: national standard Z10970022) and children food retention removing and cough stopping granules (approved document: national standard Z20060159), and the trade names thereof
Figure BDA0002555580470000011
Are all Chinese patent medicine products of Lunan Qianpu pharmaceutical Co. The Wangbai and the like adopt a random, contrast and multi-center clinical research method to prove that the total effective rate of the curative effect of the oral liquid for removing food retention and relieving cough for treating the symptoms of phlegm-heat cough and food retention in children is 84.71 percent, and no adverse drug reactions (Wangbai, et al, modern medicine and clinic, No. 25, No. 5 of 2010).
Betel nut is used as a main medicine in the prescription of the preparation for removing food retention and relieving cough for children, is dry mature seed of Areca nut Areca catechu L, and is widely used for treating diseases such as abdominal pain due to parasitic infestation, food retention, qi stagnation, edema, beriberi and the like for a long time. In recent years, in southern areas such as Hunan, Hainan and Taiwan, wind is prevailing for chewing betel nuts, and the edible betel nuts are prepared by processing fresh or dried young fruits of Areca catechu L. However, studies on eating betel nuts show that long-term chewing of betel nuts can lead to addiction, possibly even carcinogenesis or other toxic and side effects. The international agency for research on cancer (IARC) in 2003 placed Areca nut (Areca nut) on the list of class 1 carcinogens. It should be noted that, the medicinal betel nut is decocted with a conventional dose for oral administration, and no experimental and clinical research reports are reported yet for causing cancer or toxic and side effects.
Cicada slough serving as an animal medicine in a formula of a preparation for removing food retention and relieving cough for children is a peel shell which falls off when nymphs of Cryptotympana pustulata Fabricius of cicada animals, and is widely used for treating wind-heat type cold, pharyngalgia hoarseness, measles imperviousness, rubella pruritus, convulsion and the like in clinic. For a long time, cicada slough medicinal materials are all from wild, and naturally fallen shells are picked up manually for medicinal use. Particularly, in recent years, with the continuous expansion of the activity range of human beings, the living space of the black locust is greatly compressed, the growth conditions of the black locust are damaged along with the use of a large amount of chemical fertilizers and pesticides, and the reproduction of the black locust is further damaged when the nymphs are eaten in a large amount, so that the medicinal material resources of the cicada slough and the annual yield are continuously reduced directly due to the reasons. The habitat space of the black locust in China is still not optimistic within a foreseeable time, so that the yield of the cicada slough medicinal material tends to shrink day by day and even runs out, and further the medicinal material market supply and the production of related traditional Chinese medicine products are seriously influenced.
Disclosure of Invention
In view of the problems of betel nut and cicada slough 2 medicines in the formulation of the children stagnation-removing and cough-relieving preparation, the potential toxicity of the betel nut should be scientifically examined according to the scientific and careful attitude so as to avoid the health risk; aiming at the current situation that the resource supply of the cicada slough is gradually reduced, reasonable and ordered utilization of wild medicinal material resources is realized from saving and intensive utilization of the wild medicinal material resources. Therefore, the invention aims to provide a novel traditional Chinese medicine composition for treating the infantile indigestion with food retention and phlegm heat cough and a preparation method thereof (CN1425447A) on the basis of the traditional Chinese medicine to analyze the etiology and pathogenesis of the infantile indigestion with food retention and phlegm heat cough, and aims to provide the traditional Chinese medicine composition for treating the infantile indigestion with food retention and phlegm heat cough and the preparation method thereof, so that the magnolia officinalis and the burdock carry out targeted effective substitution on the betelnut and the cicada slough 2 medicines in the original composition, and the characteristics of phlegm heat accumulation of the disease are combined, and 4 medicines of dried orange peel, pinellia ternate, scutellaria baicalensis and cortex mori radicis added, so that the functional indications and the exact clinical curative effect of the infantile indigestion with food retention and phlegm cough relieving composition are basically maintained, the effects of clearing heat and eliminating phlegm are enhanced, the product production dilemma caused by the shortage of medicinal material resources can be solved, and the possible potential toxicity risk can be avoided.
The invention aims to provide a traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough, which is prepared from hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, radish seed, semen lepidii, burdock, cortex mori radicis and folium eriobotryae, has the effects of clearing heat, regulating lung, helping digestion, eliminating stagnation, reducing phlegm and relieving cough, and is used for treating infantile indigestion with phlegm-heat cough symptoms such as heavy cough and aggravation at night, wheezy phlegm in throat, excessive phlegm or little phlegm, difficult expectoration, feverish sensation in palms and soles, abdominal distension, anorexia, halitosis, dry stool, red tongue with thick greasy coating and the like.
The invention relates to a traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough, which is prepared from the following traditional Chinese medicine components:
Figure BDA0002555580470000031
the traditional Chinese medicine composition comprises the following raw materials in preferred weight ratio:
Figure BDA0002555580470000032
the optimal weight ratio of the raw materials of the traditional Chinese medicine composition is as follows:
Figure BDA0002555580470000033
preferably, the hawthorn is fried hawthorn, the pinellia ternate is prepared pinellia ternate, the magnolia officinalis is ginger-processed magnolia officinalis, the radish seed is fried radish seed, the semen lepidii is fried semen lepidii, the burdock seed is fried burdock, and the loquat leaf is honey-processed loquat leaf.
Spleen earth is the mother of lung meridian, and children's cough due to retention of food and phlegm-heat belongs to the "mother disease and child", so it should be treated by both lung and spleen; food stagnation is the root of the disease, and phlegm cough is the symptom of the disease, so it is necessary to treat the disease at the root and treat both the symptoms and root causes. In the recipe, hawthorn has the functions of removing food retention and resolving stagnation, can eliminate all food retention and especially is good at eliminating greasy food retention of meat, and is called as sour and slightly sweet in taste and can supplement sour juice in stomach, so that food retention and accumulation can be eliminated to treat meat accumulation, which is particularly effective in the medical science records of Zhongzhong Zhong xi; lai Fu Zi can direct qi downward, promote digestion and resolve phlegm, which is good at relieving the accumulation of cereal and flour, so it is said in Ben Cao Xin Shu that it is effective in relieving dyspnea, cough and dyspnea, and relieving flour food. The two herbs are mutually reinforced to promote digestion and remove food stagnation, so that food stagnation can be eliminated, so that stagnation of heat and phlegm will not be followed, and heat generation and phlegm generation will not be caused.
The spleen is the source of phlegm generation, and the lung is the qi for storing phlegm. Pinellia ternate is a key medicine for strengthening spleen and stomach and eliminating phlegm, enters spleen and stomach and lung meridian to make spleen strengthen dampness and remove, so that phlegm is not originated, enters lung to disperse and dissolve lung, and is not remained, so that pinellia ternate is called as a main phlegm and is assisted by cold and heat clearing medicines in the invention of materia medica. Tangerine peel, pericarpium Citri Reticulatae regulates qi to invigorate the spleen, eliminates dampness and phlegm, and is also an essential herb for treating phlegm, "all patients with cough and phlegm have the best effect of treating lung with pungent and sweet flavor" ("Puji Fang-cough gate"), "Changsha Yao Ji" (Changsha Yao Ji) is good at lowering turbid pathogen and relieving vomiting, activating stagnancy and eliminating phlegm, harmonizing with the other things without breaking qi and damaging healthy qi, and also good herb for moving stagnation and regulating qi. Ban Xia can dispel phlegm by guiding qi downward with the help of Chen Pi; tangerine peel, pericarpium Citri Tangerinae and pinellia Tuber can help to remove phlegm and direct qi downward. Snakegourd fruit has the functions of clearing heat, resolving phlegm, and resolving stagnation, and is recorded in the book Ben Cao Yan Yi Bu Yi (supplement to the Yan Yi of materia Medica): sweet in flavor and moist in nature, sweet in flavor can tonify lung, moisten body and descend qi. For phlegm in the chest, it is the essential herb for cough because it is sweet and mild in action of descending, so it is indicated for lung fire to expel and lose the action of descending. The two herbs of Gua Lou and ban Xia are combined to strengthen the actions of resolving phlegm and dissipating nodulation by combining cold and warm herbs and applying dryness and moistening mutually. Platycodon grandiflorum is yellow millet which is a medicine for opening lung qi, eliminating phlegm and benefiting qi, and the essential herbs for relieving depression and promoting phlegm are also not for cough and dyspnea with the effect of regulating qi and eliminating phlegm (materia Medica in materia Medica), which is a yellow millet which is a medicine for opening lung qi. The pinellia ternate and the like are used together to mutually promote, disperse and descend in order, so that spleen qi is transported and phlegm is self-transformed, the effects of regulating qi and reducing phlegm are achieved, and the pinellia ternate and the like are used as ministerial drugs.
Food stagnation is apt to cause heat transformation, and heat-clearing herbs should be added on the basis of food stagnation. Baikal skullcap root, bitter in taste and cold in nature, excels in clearing lung fire and excessive heat in upper energizer, "Du Jiang Tan Huo cough, dyspnea and Chun Qin Mo Neng Qing" (materia Medica), and "Ben Cao invent" means that it "removes damp heat in stomach and eliminates grain, does not kill grain with pathogenic heat, can remove heat, then stomach and grain disappear ". Ting Li Zi is bitter and descending and pungent in property, cold in nature and clearing heat, specially purging phlegm fire and fluid retention in lung to relieve dyspnea and cough, so it is good for treating cough caused by lung obstruction, relieving dyspnea and removing phlegm retention in chest, and for descending qi and moving phlegm and clearing heat in lung, as recorded in KAI BAO BENCH. Mulberry bark, cortex Mori, with its cold nature, exclusively enters lung meridian to lower lung fire, purge lung qi and resolve phlegm cough, is mainly indicated for dyspnea with cough and heat phlegm and spittle blood, which are caused by stagnation of excess pathogen and obstructed lung orifice, so it seeps and disperses to promote lung qi and cure all syndromes. Loquat leaves, with bitter taste and cold nature, can clear and descend lung qi to relieve cough, so all the pathogens of wind, dampness, warm, heat, summer-heat and dryness in lung can be used to protect soft gold (meaning lung) to descend and cure the disease (Chongqing Tang Nianjiao). The four medicines, the scutellaria is good at clearing lung heat, the lepidium seed, the mulberry bark and the loquat leaf have the functions of clearing lung heat, eliminating phlegm, descending qi and relieving asthma, and the medicines are mutually used for greatly enhancing the effect of clearing lung heat and relieving cough and are also used as ministerial medicines together.
Food retention may cause abdominal distension due to improper diet and dysfunction of spleen in transportation and qi stagnation in the stomach and intestine. Zhi Shi is good at breaking qi and relieving stuffiness, and resolving food stagnation, so it is called in Ben Cao Hua Yi that it is named as "specially purging stomach and food … …, with fierce nature and rapid action of opening and resolving hard mass, and has the action of pushing wall and pouring wall", and it is also used for pungent, bitter and diarrhea-relieving because of spleen qi stagnation and failure of transportation and transformation if there is no desire for diet. It is the most important herb for qi in blood. Hou Po also purges the middle energizer, relieves stagnation and removes stasis, "Hou Po is used in ancient prescription for purging qi of accumulation and stagnation" (compendium of medicine), "all kinds of food stagnation, qi stagnation and fulminant swelling … …, Cheng is essential herb" (Ben Cao Jing Shu). The bitter orange and the magnolia bark are bitter and cold in nature and pungent and warm in nature, and are combined with each other, so that the cold and the heat can be mutually prepared, the cold and the heat can complement each other, the monarch and ministerial medicines can be better assisted to strengthen the effects of removing food retention and promoting qi circulation, and the traditional Chinese medicine is an assistant and guide medicine.
In addition, "the most children's diseases are impaired by food and the most children's diseases are mostly hot," as said in the book of junior science, the most children's febrile diseases belong to pure yang, six qi are involved, and both qi and blood are converted into heat; the food is not transformed into food, and it is steamed inside, also transforming into heat. Forsythia fruit has the actions of clearing heat and removing toxicity, dispelling wind and heat, so it can be used for both clearing stomach heat and regulating the central apparatus to recover the functions of spleen and stomach, and clear food retention and heat in the stomach to stop vomiting, because Forsythia fruit has a strong and cool nature and qi in the qi system. Great burdock achene has the effects of dispersing lung heat, ventilating and smoothing lung, eliminating phlegm, relieving sore throat, promoting eruption, detoxifying and diminishing swelling, and is recorded in the book of drug property endowment: arctium lappa fruit is used for dispelling wind and eliminating phlegm. It is said that "the herbs in Yao Hua Yi" can ascend and descend, relieve heat and toxicity, and have bitter flavor and clear fire, pungent flavor and dispel wind … …, so it is indicated for stagnant fire in lung meridian and wind-heat in lung meridian. The two medicines not only assist ministerial medicines in strengthening the heat-clearing function of lung and stomach, but also play the roles of detoxifying and relieving sore throat aiming at secondary and concurrent syndromes, and are also used as adjuvant and conductant medicines.
Based on the physiological and pathological characteristics of young yin and yang of children, incomplete qi, frequent insufficiency of spleen, easy deficiency and easy excess, the medicines are formulated according to the compatibility theory of monarch, minister, assistant and guide traditional Chinese medicine and following the treatment and tonifying concepts of simultaneous treatment of lung and spleen, treatment of both symptoms and root causes and taking the stage of peace as the stage, so that the effects of promoting digestion, resolving food stagnation and guiding stagnation are achieved, the effects of clearing lung, eliminating phlegm and relieving cough are achieved, the medicines are combined, the effects of clearing heat, regulating lung, promoting digestion, resolving food stagnation, eliminating phlegm and relieving cough are achieved, and the infant patients with the syndrome of food stagnation, phlegm and heat and cough can obtain good effects.
The invention also aims to provide an oral liquid preparation containing the traditional Chinese medicine composition and a preparation method thereof, and the oral liquid preparation is preferably oral liquid, granules, chewable tablets, syrup or soft extract.
The preferred preparation form of the invention is oral liquid, and the preparation method of the oral liquid comprises the following steps:
A. weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding water for decocting for 1-3 times, 2-3 hours each time, merging decoction, filtering, concentrating filtrate under reduced pressure to obtain extract with the relative density of 1.10-1.25 at 50 ℃, adding ethanol to ensure that the alcohol content reaches 50% -70%, standing for cold precipitation for 12-48 hours, filtering, recovering ethanol from filtrate to obtain extract with the relative density of 1.25-1.35 at 50 ℃, adding 6 times of purified water for carrying out rotary dissolution and fine precipitation for 48 hours, filtering, concentrating filtrate under reduced pressure to obtain extract with the relative density of 1.25-1.30 at 50 ℃, adding purified water to the total preparation amount to obtain water extract, carrying out cold precipitation for 72 hours, and filtering to obtain filtrate for later use;
B. adding 1.0-3.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 6.6-7.3, adding cyclodextrin with the total preparation amount of 1.0-6.0% (weight/volume), controlling the inclusion temperature to be 20-30 ℃ and including for 45-90 minutes, and filtering to obtain filtrate for later use;
C. and C, adding cane sugar accounting for 10-50% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing for 60 minutes by flowing steam at 100 ℃, and packaging to obtain the product.
Preferably, step A is decocted in water 2 times, 2 hours each time.
Preferably, step A is performed by adding 95% ethanol to obtain 60% ethanol content.
In order to verify the efficacy of the traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough, the inventor develops pharmacodynamic test research and pharmaceutical clinical research. It should be noted that the drug selected in the pharmacodynamic test and clinical study of the drug of the present invention is a drug obtained by the representative formulation and the preparation method thereof, and the tests and results related to the other formulations and the drugs obtained by the preparation method of the present invention are not exhaustive due to space limitations.
Experimental example 1 Effect on gastrointestinal motility and motilin levels in rats which are models of dyspepsia
1 Material
1.1 experimental animals and feed SPF grade healthy SD rats, 60 animals, half male and female, body weight (60 + -5) g, provided by Lunan pharmaceutical group, Inc., and the license number of experimental animals: SYXK (lu) 20180008. The method is characterized in that the animal is bred adaptively for 1 week in a clean-grade animal laboratory before experiment, male and female parts are separated, the room temperature is 20-25 ℃, the relative humidity is 40% -60%, natural illumination is carried out, and free food intake and drinking are carried out.
The conventional feed is provided by Australian cooperative feed Co., Ltd of Beijing Ke; the special feed is high-protein and high-heat feed, and is prepared by mixing dried fish floss, bean powder, flour and milk powder at a ratio of 1:2:1:1, adding water to obtain cylindrical feed similar to conventional feed, and drying with electrothermal constant temperature air drying oven.
1.2 electronic analytical balance model XS204 instrument, reagents and drugs (Mettler-Toledo, Switzerland); medifuge Small bench centrifuge (Thermo Fisher, USA); model 680 full-automatic enzyme labeling machine (Bio-Rad, USA); DW-86L626 type ultra-low temperature storage box (Qingdao Haier Special appliances Co., Ltd.). Motilin (MTL) enzyme-linked immunosorbent assay (ELISA) kit was purchased from Nanjing Bioscience Agents. The nutritional semisolid paste is prepared by dissolving 16g of sodium carboxymethylcellulose in 400mL of distilled water, sequentially adding 25.6g of milk powder, 12.8g of glucose, 12.8g of corn starch and 50.7g of 10% activated carbon powder, stirring uniformly, refrigerating at 4 ℃, and returning to room temperature when in use.
The test drug was an oral liquid sample prepared according to the formulation and preparation method of example 5; the positive control drug oral liquid (batch: 00419312) for removing food retention and relieving cough for children is produced by Lunan Kangpu pharmaceutical Co., Ltd, and has the specification: 10 mL/bottle (1 g crude drug per mL).
2 method
2.1 grouping and modeling 60 healthy SD rats, and dividing the SD rats into 6 groups by a random digital table remainder method, namely a normal control group, a model control group, a positive control group, a test high-dose group, a test medium-dose group and a test low-dose group, wherein each group comprises 10 rats and each half of male rats and female rats. In the experiment, except the normal control group, the other 5 groups are fed with the special feed, and are simultaneously fed with milk with the concentration of 50% for intragastric administration for 1 mL/time and 1 time/d, and each group freely takes food and drinks and continuously molds for 15 d. Food intake and body weight of each rat were recorded daily. After the model is made, the rat has decreased appetite, slow action, narrow eyes, listlessness and obvious stomach enlargement, and a large amount of food residues in the stomach can be found after the model is dissected, thereby proving the success of the model making.
2.2 after the model is successfully made, feeding each group with conventional feed, and carrying out dose conversion according to dose conversion coefficients of different animals in the appendix of the clinical research guiding principle of new traditional Chinese medicines, wherein a positive control group is administered with 15/kg/d (20 times of human dose) of the oral liquid for removing food retention and relieving cough for children, a test high dose group, a test medium dose group and a test low dose group are administered with 15g/kg/d (20 times of human dose), 7.5g/kg/d (10 times of human dose) and 3.75g/kg/d (5 times of human dose) of the tested medicines in sequence, a normal control group and a model control group are administered with normal saline with equal volume, and the administration is carried out for 1 time every day and the administration is carried out for 15d continuously.
2.3 detection index and method
(1) Determination of Motilin (MTL) in peripheral blood: after 14d administration, fasting is carried out for 16h without water prohibition, each group is drenched with 2 mL/body of nutritional semisolid paste after 15d administration for 40min, after 20min, 10% chloral hydrate (0.30mL/100g) is used for abdominal anesthesia, abdominal aorta is quickly sampled, the obtained mixture is injected into an EDTA tube to be fully shaken and immediately stored at 4 ℃, and the obtained mixture is centrifuged at 4000r/min for l0min within 3h and stored at-80 ℃ to be tested. The content of Motilin (MTL) in peripheral blood is detected by a radioimmunoassay.
(2) Determination of the rate of intestinal transit: after the abdominal aorta blood sampling is finished, the rat is killed by dislocation of cervical vertebra immediately, mesentery is separated rapidly, small intestine is taken out and laid on white paper, and the distance from pylorus to the full length of ileocecal part and the distance from pylorus to the front edge of carbon-powder semisolid paste are measured. The percentage of the distance from the pylorus to the front edge of the carbon powder semisolid paste to the whole length from the pylorus to the ileocecal part is taken as the small intestine propulsion rate:
the small intestine propulsion rate (%) (the distance of the carbon-powder semisolid paste propelled in the small intestine/the full length of the rat small intestine) × 100%.
2.4 statistical processing SPSS19.0 statistical software was used for analysis, and the experimental data are expressed as "mean. + -. standard deviation
Figure BDA0002555580470000073
Figure BDA0002555580470000074
) "is expressed in terms of a form. The comparison among groups was performed by one-way anova, with P < 0.05 indicating that the difference was statistically significant.
3 results of
3.1 Effect on rat Small intestine Propulsion Rate
Compared with the normal control group, the small intestine propulsion rate of the model control group rats is relatively low, and the difference has statistical significance (P is less than 0.05). After administration for 15 days, compared with a model control group, the small intestine propulsion rates of rats in a positive control group and a test high, medium and low dose group are improved, and the differences have statistical significance (P is less than 0.05); compared with a normal control group, the small intestine propulsion rate of the positive control group and the small intestine propulsion rate of the test high-dose group are higher, and the difference has statistical significance (P is less than 0.05). After 15 days of administration, compared with a positive control group, the small intestine propulsion rate of the middle and low dose groups in the test is lower, and the difference is obvious (P is less than 0.05). The results are shown in Table 1.
TABLE 1 Effect on the rate of Small intestine propulsion in rats model for dyspepsia: (
Figure BDA0002555580470000071
％)
Figure BDA0002555580470000072
Note: compared with a normal control group, # P < 0.05; p < 0.05 compared to model control; compared to the normal control group, P < 0.05; p < 0.05 compared to the positive control group.
3.2 Effect on rat Motilin (MTL) content
Compared with the normal control group, the peripheral blood Motilin (MTL) content of the rats in the model control group is relatively low, and the difference has statistical significance (P is less than 0.05). After administration for 15 days, compared with a model control group, the content of Motilin (MTL) in peripheral blood of a positive control group and a test high, medium and low dose group is improved, and the difference has statistical significance (P is less than 0.05); compared with a normal control group, the positive control group and the test high-dose group have higher peripheral blood Motilin (MTL) content, and the difference has statistical significance (P is less than 0.05). Meanwhile, after 15d of administration, compared with a positive control group, the content of Motilin (MTL) in peripheral blood of the middle and low dose groups in the test is lower, and the difference is obvious (P is less than 0.05). The results are shown in Table 2.
TABLE 2 peripheral blood MTL of rats for the dyspepsia modelInfluence of content (
Figure BDA0002555580470000081
pg/mL)
Figure BDA0002555580470000082
Note: compared with a normal control group, # P < 0.05; p < 0.05 compared to model control; compared to the normal control group, P < 0.05; p < 0.05 compared to the positive control group.
Detailed Description
The invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way, as will be appreciated by those skilled in the art.
Example 1 preparation of an oral liquid for eliminating food stagnation and relieving cough in children
Figure BDA0002555580470000083
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 9 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining decoction, filtering, concentrating filtrate under reduced pressure to extract with the relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 70%, standing for cold precipitation for 48 hours, filtering, recovering ethanol from filtrate to extract with the relative density of 1.25 at 50 ℃, adding 6 times of purified water for carrying out rotary dissolution and fine extraction and precipitation for 48 hours, filtering, concentrating filtrate under reduced pressure in vacuum to extract with the relative density of 1.25 at 50 ℃, adding purified water to 10L to prepare water extract, carrying out cold precipitation for 48 hours, and filtering to obtain filtrate for later use;
B. adding 2.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 7.1, adding 5.0% (weight/volume) of cyclodextrin to the total preparation amount, controlling the inclusion temperature to be 30 ℃, stirring for inclusion for 50 minutes, and filtering to obtain filtrate for later use;
C. and C, adding cane sugar accounting for 20% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 2 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000091
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 12 times of water, decocting for 3 hours, mixing the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with the relative density of 1.10 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 50%, standing for cold precipitation for 48 hours, filtering, recovering ethanol from the filtrate to obtain an extract with the relative density of 1.30 at 50 ℃, adding 6 times of purified water for rotary dissolution and fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure in vacuum to obtain an extract with the relative density of 1.30 at 50 ℃, adding purified water to 10L to obtain a water extract, performing cold precipitation for 36 hours, and filtering to obtain a filtrate for later use;
B. adding 1.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 6.6, adding cyclodextrin with the total preparation amount being 1.0% (weight/volume), controlling the inclusion temperature to be 25 ℃, stirring for inclusion for 45 minutes, and filtering to obtain filtrate for later use;
C. and C, adding cane sugar accounting for 10 percent of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by flowing steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the finished product.
EXAMPLE 3 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000092
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 1 hour, adding 6 times of water for the third time, decocting for 1 hour, combining decoction solutions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.15 at 50 ℃, adding 95% ethanol to ensure that the ethanol content reaches 60%, standing for cold precipitation for 12 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.35 at 50 ℃, adding 6 times of purified water for rotary dissolution and fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.35 at 50 ℃, adding 10L of purified water to prepare a water extract, performing cold precipitation for 24 hours, and filtering to obtain a filtrate for later use;
B. adding 3.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 7.0, adding cyclodextrin of which the total preparation amount is 3.0% (weight/volume), controlling the inclusion temperature to be 20 ℃, stirring for inclusion for 75 minutes, and filtering to obtain filtrate for later use;
C. and C, adding cane sugar accounting for 50% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 4 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000101
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 9 times of water for the first time, decocting for 3 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 70%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.25 at 50 ℃, adding 6 times of purified water for carrying out fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.25 at 50 ℃, adding purified water to 10L to prepare a water extract, carrying out cold precipitation for 72 hours, and filtering to obtain a filtrate for later use;
B. adding 2.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 7.3, adding cyclodextrin of which the total preparation amount is 4.0% (weight/volume), controlling the inclusion temperature to be 30 ℃, stirring for inclusion for 60 minutes, and filtering to obtain filtrate for later use;
C. and C, adding sucrose accounting for 40% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 5 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000102
Figure BDA0002555580470000111
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.30 at 50 ℃, adding 6 times of purified water for carrying out fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.30 at 50 ℃, adding purified water to 10L to prepare a water extract, carrying out cold precipitation for 72 hours, and filtering to obtain a filtrate for later use;
B. adding 1.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 7.0, adding cyclodextrin of which the total preparation amount is 3.0% (weight/volume), controlling the inclusion temperature to be 20 ℃, stirring for inclusion for 60 minutes, and filtering to obtain filtrate for later use;
C. and C, adding sucrose accounting for 40% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 6 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000112
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 3 hours, adding 8 times of water for the second time, decocting for 1 hour, combining decoction, filtering, concentrating filtrate under reduced pressure to extract with the relative density of 1.25 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from filtrate to extract with the relative density of 1.25 at 50 ℃, adding 6 times of purified water for carrying out rotary dissolution and fine extraction and precipitation for 48 hours, filtering, concentrating filtrate under reduced pressure in vacuum to extract with the relative density of 1.25 at 50 ℃, adding purified water to 10L to prepare water extract, carrying out cold precipitation for 72 hours, and filtering to obtain filtrate for later use;
B. adding 1.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 6.9, adding cyclodextrin with the total preparation amount of 3.0% (weight/volume), controlling the inclusion temperature to be 30 ℃, stirring for inclusion for 50 minutes, and filtering to obtain filtrate for later use;
C. and C, adding cane sugar accounting for 20% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 7 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000121
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 9 times of water for the first time, decocting for 3 hours, adding 8 times of water for the second time, decocting for 1 hour, adding 8 times of water for the third time, decocting for 1 hour, combining decoction solutions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.15 at 50 ℃, adding 95% ethanol to ensure that the ethanol content reaches 50%, standing for cold precipitation for 48 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.30 at 50 ℃, adding 6 times of purified water for rotary dissolution and fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.30 at 50 ℃, adding 10L of purified water to obtain a water extract, performing cold precipitation for 48 hours, and filtering to obtain a filtrate for later use;
B. adding 1.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 7.2, adding cyclodextrin with the total preparation amount of 6.0% (weight/volume), controlling the inclusion temperature to be 20 ℃, stirring for inclusion for 80 minutes, and filtering to obtain filtrate for later use;
C. and C, adding sucrose accounting for 30% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 8 preparation of an oral liquid for eliminating food stagnation and relieving cough in children
Figure BDA0002555580470000122
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.1 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 70%, standing for cold precipitation for 12 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.25 at 50 ℃, adding 6 times of purified water for carrying out fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.25 at 50 ℃, adding purified water to 10L to prepare a water extract, carrying out cold precipitation for 24 hours, and filtering to obtain a filtrate for later use;
B. adding 2.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 7, adding 2.0% (weight/volume) of cyclodextrin to the total preparation amount, controlling the inclusion temperature to be 30 ℃, stirring and including for 80 minutes, and filtering to obtain filtrate for later use;
C. and C, adding sucrose accounting for 40% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
EXAMPLE 9 preparation of pediatric oral liquid for removing food retention and relieving cough
Figure BDA0002555580470000131
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 9 times of water for the first time, decocting for 3 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.2 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.3 at 50 ℃, adding 6 times of purified water for carrying out fine extraction and precipitation for 48 hours, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.3 at 50 ℃, adding purified water to 10L to prepare a water extract, carrying out cold precipitation for 36 hours, and filtering to obtain a filtrate for later use;
B. adding 1.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 6.8, adding cyclodextrin with the total preparation amount being 1.0% (weight/volume), controlling the inclusion temperature to be 25 ℃, stirring for inclusion for 60 minutes, and filtering to obtain filtrate for later use;
C. and C, adding sucrose accounting for 30% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing by circulating steam at 100 ℃ for 60 minutes at a specification of 10 ml/piece, and packaging to obtain the product.
Example 10 preparation of XIAOERGANXIAOZHIKE granule
Figure BDA0002555580470000132
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.30 at 50 ℃, adding 6 times of purified water, performing rotary dissolution and fine extraction on the extract for 48 hours, filtering, and concentrating the filtrate under reduced pressure under vacuum to obtain an extract with a relative density of 1.30 at 50 ℃ for later use;
B. and C, drying the extract in the step A in vacuum, crushing the extract into fine powder, adding cyclodextrin accounting for 3 percent (g/g) of the total amount of the extract and sucrose powder accounting for 40 percent (g/g) of the total amount of the extract, uniformly mixing, preparing into granules, drying and packaging to obtain the finished product.
EXAMPLE 11 preparation of chewable tablets for eliminating food stagnation and relieving cough for children
Figure BDA0002555580470000141
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.30 at 50 ℃, adding 6 times of purified water, performing rotary dissolution and fine extraction on the extract for 48 hours, filtering, and concentrating the filtrate under reduced pressure under vacuum to obtain an extract with a relative density of 1.30 at 50 ℃ for later use;
B. and (B) drying the extract in vacuum, crushing into fine powder, adding cyclodextrin accounting for 3% (g/g) of the total amount of the extract and sucrose powder accounting for 40% (g/g) of the total amount of the extract, uniformly mixing, granulating, drying, uniformly mixing, tabletting and packaging to obtain the finished product.
EXAMPLE 12 preparation of syrup for eliminating food stagnation and relieving cough in children
Figure BDA0002555580470000142
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining decoction, filtering, concentrating filtrate under reduced pressure to extract with the relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from filtrate to extract with the relative density of 1.30 at 50 ℃, adding 6 times of purified water for rotary dissolution and fine extraction for precipitation for 48 hours, filtering, and concentrating filtrate under reduced pressure in vacuum to extract with the relative density of 1.30 at 50 ℃ for later use;
B. and C, adding 3.0% of cane sugar into the extract in the step A to prepare syrup, stirring and uniformly mixing to obtain the extract.
EXAMPLE 13 preparation of XIAOERGANXIAOJIZHIKE Soft extract
Figure BDA0002555580470000151
A. Weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding 10 times of water for the first time, decocting for 2 hours, adding 8 times of water for the second time, decocting for 2 hours, combining the decoctions, filtering, concentrating the filtrate under reduced pressure to obtain an extract with a relative density of 1.20 at 50 ℃, adding 95% ethanol to ensure that the alcohol content reaches 60%, standing for cold precipitation for 24 hours, filtering, recovering ethanol from the filtrate to obtain an extract with a relative density of 1.30 at 50 ℃, adding 6 times of purified water, performing rotary dissolution and fine extraction on the extract for 48 hours, filtering, and concentrating the filtrate under reduced pressure under vacuum to obtain an extract with a relative density of 1.30 at 50 ℃ for later use;
B. and (C) taking the extract in the step A, adding refined sugar which is 1 time of the extract into the extract, stirring and uniformly mixing, slightly refining, removing foams, filling into an aseptic bottle, and sealing to obtain the traditional Chinese medicine composition.

Claims (7)

1. A traditional Chinese medicine composition for treating infantile indigestion with phlegm-heat cough is characterized by being prepared from the following traditional Chinese medicine components:
100 parts by weight of hawthorn, 100 parts by weight of pinellia tuber, 100 parts by weight of dried orange peel
135 parts of snakegourd fruit, 100 parts of immature bitter orange and 100 parts of magnolia bark
100 parts by weight of scutellaria baicalensis, 100 parts by weight of forsythia suspensa, 100 parts by weight of platycodon grandiflorum
100 parts by weight of radish seed 100 parts by weight of pepperweed seed 100 parts by weight of great burdock achene 100 parts by weight
100 parts of cortex mori radicis and 100 parts of folium eriobotryae.
2. The Chinese medicinal composition as claimed in claim 1, wherein the fructus crataegi is parched fructus crataegi, the rhizoma Pinelliae is prepared rhizoma Pinelliae Preparata, cortex Magnolia officinalis is ginger cortex Magnolia officinalis, Raphani semen is parched Raphani semen, semen Lepidii is parched semen Lepidii, fructus Arctii is parched fructus Arctii, and folium Eriobotryae is folium Eriobotryae preparata.
3. The traditional Chinese medicine composition of claim 1 or 2, wherein the traditional Chinese medicine composition is an oral pharmaceutical preparation.
4. The traditional Chinese medicine composition of claim 3, wherein the oral pharmaceutical preparation is oral liquid, granules, chewable tablets, syrup or soft extract.
5. The traditional Chinese medicine composition of claim 4, wherein the preparation method of the oral liquid comprises the following steps:
A. weighing 14 medicinal materials of hawthorn, pinellia ternate, dried orange peel, platycodon grandiflorum, snakegourd fruit, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, white mulberry root-bark and loquat leaf, adding water for decocting for 1-3 times, 2-3 hours each time, merging decoction, filtering, concentrating filtrate under reduced pressure to extract with the relative density of 1.10-1.25 at 50 ℃, adding ethanol to ensure that the alcohol content reaches 50-70%, standing for cold precipitation for 12-48 hours, filtering, recovering ethanol from filtrate to extract with the relative density of 1.25-1.35 at 50 ℃, adding 6 times of purified water for converting for fine extraction and precipitation for 48 hours, filtering, concentrating filtrate under reduced pressure to extract with the relative density of 1.25-1.30 at 50 ℃, adding purified water to the total preparation amount to prepare water extract, performing cold precipitation for 24-72 hours, and filtering to obtain filtrate for later use;
B. adding 1.0-3.0% of activated carbon into the filtrate obtained in the step A, heating and boiling for 60 minutes, filtering to remove carbon, adding purified water to the total preparation amount, adjusting the pH value to be 6.6-7.3, adding 1.0-6.0% of the total preparation amount, adding cyclodextrin calculated by mass/volume, controlling the inclusion temperature to be 20-30 ℃ and including for 45-90 minutes, and filtering to obtain filtrate for later use;
C. and C, adding cane sugar accounting for 10-50% of the total weight of the preparation into the filtrate obtained in the step B, stirring and dissolving, adding purified water to the total preparation amount, filtering until the clarity is qualified, filling, sterilizing for 60 minutes by flowing steam at 100 ℃, and packaging to obtain the product.
6. The Chinese medicinal composition according to claim 5, wherein the preparation method comprises decocting step A in water for 2 times, each for 2 hours.
7. The composition of claim 5, wherein the ethanol content in step A is 60% by adding 95% ethanol.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824105A (en) * 2005-12-27 2006-08-30 江西青春康源制药有限公司 Food dispersing cough suppressing granule for child and its preparation method
CN102188575A (en) * 2010-03-03 2011-09-21 鲁南厚普制药有限公司 Oral liquid preparation for treating infantile indigestion with food retention and cough and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824105A (en) * 2005-12-27 2006-08-30 江西青春康源制药有限公司 Food dispersing cough suppressing granule for child and its preparation method
CN102188575A (en) * 2010-03-03 2011-09-21 鲁南厚普制药有限公司 Oral liquid preparation for treating infantile indigestion with food retention and cough and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
桔梗克咳糖浆的制备及临床观察;刘安龙等;《光明中医》;20140531;第29卷(第5期);第1102页第1.1和1.3节，第1103页右栏第1段 *

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