CN116981678A - 包括用于与载体材料缀合的抗原前体的反应性碳水化合物的合成方法 - Google Patents

包括用于与载体材料缀合的抗原前体的反应性碳水化合物的合成方法 Download PDF

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Publication number
CN116981678A
CN116981678A CN202280021326.5A CN202280021326A CN116981678A CN 116981678 A CN116981678 A CN 116981678A CN 202280021326 A CN202280021326 A CN 202280021326A CN 116981678 A CN116981678 A CN 116981678A
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China
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formula
compound
reaction
hours
group
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Pending
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CN202280021326.5A
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English (en)
Chinese (zh)
Inventor
T·C·希奥
S·米格纳尼
S·莫菲特
R·维什瓦卡玛
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Koranks Capital
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Koranks Capital
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Publication of CN116981678A publication Critical patent/CN116981678A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CN202280021326.5A 2021-01-15 2022-01-14 包括用于与载体材料缀合的抗原前体的反应性碳水化合物的合成方法 Pending CN116981678A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN202121001963 2021-01-15
IN202121001963 2021-01-15
PCT/CA2022/050054 WO2022150924A1 (en) 2021-01-15 2022-01-14 Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material

Publications (1)

Publication Number Publication Date
CN116981678A true CN116981678A (zh) 2023-10-31

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ID=82446854

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280021326.5A Pending CN116981678A (zh) 2021-01-15 2022-01-14 包括用于与载体材料缀合的抗原前体的反应性碳水化合物的合成方法

Country Status (9)

Country Link
US (1) US20240308991A1 (https=)
EP (1) EP4277914A4 (https=)
JP (1) JP2024504658A (https=)
KR (1) KR20230148332A (https=)
CN (1) CN116981678A (https=)
AU (1) AU2022207897A1 (https=)
CA (2) CA3244715A1 (https=)
IL (1) IL304459A (https=)
WO (1) WO2022150924A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193563A1 (en) * 1997-08-28 2002-12-19 Koganty R. Rao Randomly generated glycopeptide combinatorial libraries
US20190290746A1 (en) * 2018-03-23 2019-09-26 Koranex Capital Precision glycoconjugates as therapeutic tools

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2967068A1 (fr) * 2010-11-09 2012-05-11 Univ Joseph Fourier Derives de 6-amino-desoxyglucosamine et leur utilisation comme agents antibacteriens
CA3061205A1 (en) * 2017-04-25 2018-11-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues
CN115003330A (zh) * 2019-09-23 2022-09-02 科纳克斯资本 作为疫苗和诊断工具的新糖缀合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020193563A1 (en) * 1997-08-28 2002-12-19 Koganty R. Rao Randomly generated glycopeptide combinatorial libraries
US20190290746A1 (en) * 2018-03-23 2019-09-26 Koranex Capital Precision glycoconjugates as therapeutic tools

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DANIELA AROSIO，ET AL.: "Synthesis and cholera toxin binding properties of multivalent GM1 mimics"", 《ORG.BIOMOL.CHEM.》, vol. 2, 30 June 2004 (2004-06-30), pages 2113 - 2124 *

Also Published As

Publication number Publication date
EP4277914A1 (en) 2023-11-22
IL304459A (en) 2023-09-01
CA3167086A1 (en) 2022-07-21
JP2024504658A (ja) 2024-02-01
AU2022207897A9 (en) 2024-05-23
US20240308991A1 (en) 2024-09-19
AU2022207897A1 (en) 2023-08-03
CA3167086C (en) 2025-12-02
CA3244715A1 (en) 2025-11-29
KR20230148332A (ko) 2023-10-24
WO2022150924A1 (en) 2022-07-21
EP4277914A4 (en) 2025-03-05

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