CA3244715A1 - Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material - Google Patents

Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material

Info

Publication number
CA3244715A1
CA3244715A1 CA3244715A CA3244715A CA3244715A1 CA 3244715 A1 CA3244715 A1 CA 3244715A1 CA 3244715 A CA3244715 A CA 3244715A CA 3244715 A CA3244715 A CA 3244715A CA 3244715 A1 CA3244715 A1 CA 3244715A1
Authority
CA
Canada
Prior art keywords
conjugation
synthesis
carrier material
carbohydrates including
including antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3244715A
Other languages
English (en)
Inventor
Tze Chieh SHIAO
Serge Mignani
Serge Moffett
Ram Vishwakarma
Original Assignee
Koranex Capital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koranex Capital Inc filed Critical Koranex Capital Inc
Publication of CA3244715A1 publication Critical patent/CA3244715A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
CA3244715A 2021-01-15 2022-01-14 Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material Pending CA3244715A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN202121001963 2021-01-15
IN202121001963 2021-01-15
CA3167086A CA3167086C (en) 2021-01-15 2022-01-14 METHOD FOR SYNTHESIZING REACTIVE CARBOHYDRATES COMPRISING ANTIGEN PRECURSORS FOR CONJUGATION WITH A SUPPORT MATERIAL

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3167086A Division CA3167086C (en) 2021-01-15 2022-01-14 METHOD FOR SYNTHESIZING REACTIVE CARBOHYDRATES COMPRISING ANTIGEN PRECURSORS FOR CONJUGATION WITH A SUPPORT MATERIAL

Publications (1)

Publication Number Publication Date
CA3244715A1 true CA3244715A1 (en) 2025-11-29

Family

ID=82446854

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3244715A Pending CA3244715A1 (en) 2021-01-15 2022-01-14 Process for the synthesis of reactive carbohydrates including antigen precursors for conjugation with a carrier material
CA3167086A Active CA3167086C (en) 2021-01-15 2022-01-14 METHOD FOR SYNTHESIZING REACTIVE CARBOHYDRATES COMPRISING ANTIGEN PRECURSORS FOR CONJUGATION WITH A SUPPORT MATERIAL

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3167086A Active CA3167086C (en) 2021-01-15 2022-01-14 METHOD FOR SYNTHESIZING REACTIVE CARBOHYDRATES COMPRISING ANTIGEN PRECURSORS FOR CONJUGATION WITH A SUPPORT MATERIAL

Country Status (9)

Country Link
US (1) US20240308991A1 (https=)
EP (1) EP4277914A4 (https=)
JP (1) JP2024504658A (https=)
KR (1) KR20230148332A (https=)
CN (1) CN116981678A (https=)
AU (1) AU2022207897A1 (https=)
CA (2) CA3244715A1 (https=)
IL (1) IL304459A (https=)
WO (1) WO2022150924A1 (https=)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1007541B1 (en) * 1997-08-28 2006-08-23 Biomira, Inc. Randomly generated glycopeptide combinatorial libraries
FR2967068A1 (fr) * 2010-11-09 2012-05-11 Univ Joseph Fourier Derives de 6-amino-desoxyglucosamine et leur utilisation comme agents antibacteriens
CA3061205A1 (en) * 2017-04-25 2018-11-01 Memorial Sloan Kettering Cancer Center Triterpene saponin analogues
WO2019178699A1 (en) * 2018-03-23 2019-09-26 Koranex Capital Precision glycoconjugates as therapeutic tools
CN115003330A (zh) * 2019-09-23 2022-09-02 科纳克斯资本 作为疫苗和诊断工具的新糖缀合物

Also Published As

Publication number Publication date
EP4277914A1 (en) 2023-11-22
IL304459A (en) 2023-09-01
CA3167086A1 (en) 2022-07-21
JP2024504658A (ja) 2024-02-01
AU2022207897A9 (en) 2024-05-23
US20240308991A1 (en) 2024-09-19
AU2022207897A1 (en) 2023-08-03
CA3167086C (en) 2025-12-02
CN116981678A (zh) 2023-10-31
KR20230148332A (ko) 2023-10-24
WO2022150924A1 (en) 2022-07-21
EP4277914A4 (en) 2025-03-05

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