CN116966109A - Moisturizing composition and application thereof - Google Patents
Moisturizing composition and application thereof Download PDFInfo
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- CN116966109A CN116966109A CN202310978921.4A CN202310978921A CN116966109A CN 116966109 A CN116966109 A CN 116966109A CN 202310978921 A CN202310978921 A CN 202310978921A CN 116966109 A CN116966109 A CN 116966109A
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- moisturizing
- extract
- skin
- moisturizing composition
- dictyophora
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 146
- 239000000203 mixture Substances 0.000 title claims abstract description 84
- 241001313734 Dictyophora Species 0.000 claims abstract description 36
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 35
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 35
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 35
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 32
- 229940101267 panthenol Drugs 0.000 claims abstract description 31
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 31
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- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 30
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical class [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims abstract description 27
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims abstract description 27
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- 235000010976 Rosa stellata var. mirifica Nutrition 0.000 claims abstract description 17
- 239000002537 cosmetic Substances 0.000 claims abstract description 9
- 239000002904 solvent Substances 0.000 claims description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical group CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 3
- 241000220317 Rosa Species 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
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- 206010013786 Dry skin Diseases 0.000 abstract description 10
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical group CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 11
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- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 description 4
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- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 3
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- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
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- 230000002950 deficient Effects 0.000 description 1
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- 229960003949 dexpanthenol Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 210000002615 epidermis Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
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- 210000002510 keratinocyte Anatomy 0.000 description 1
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- 230000008832 photodamage Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The application relates to the technical field of cosmetics, and particularly discloses a moisturizing composition and application thereof. A moisturizing composition comprises sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longispa extract, rosa canina leaf cell extract, and Sargassum obtusifolium extract. The use of a moisturizing composition in the manufacture of a cosmetic product. According to the application, through the synergistic cooperation of sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longispa extract, desert rose leaf cell extract and gulfweed extract, the five dimensions of 'absorbing', 'locking', 'fixing', 'strong' are taken together on the skin, the moisturizing capability of the skin is enhanced, and the skin has good nourishing and conditioning effects especially on dry skin.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a moisturizing composition and application thereof.
Background
One of the key steps in skin care is moisturization. If skin, especially dry skin, is not subjected to moisturizing care in daily life, the skin surface is easy to dry due to moisture loss, and the dry skin surface can further absorb moisture from the inside of the skin to supplement and keep the moisture of the skin surface, the malignant cycle directly leads to the generation speed of skin moisturizing components to be smaller than the moisture loss speed, the skin is completely dehydrated from the dermis layer to the epidermis layer, so that the skin is drier and drier, the skin elasticity is reduced, even the skin is provided with water-deficient wrinkles, and the skin aging speed is accelerated.
The existing skin care product has the effects of moisturizing the skin by supplementing water to the surface layer of the skin and reducing the loss of the water on the surface layer of the skin. However, the moisturizing effect is always limited, the skin care product applied to the face always gradually runs off from the face with the passage of time or the influence of external environment, and the skin can enter a vicious circle of gradual drying again. Therefore, it is necessary to enhance the moisturizing ability of the skin itself, and when the moisturizing ability of the skin itself is enhanced, the skin surface can be stably maintained moist for a long period of time, not depending on the moisturizing effect of the skin care product.
Disclosure of Invention
In order to further enhance the moisturizing ability of the skin itself, the present application provides a moisturizing composition and uses thereof. According to the moisturizing composition, sodium ascorbyl phosphate, saccharide isomerides, panthenol, sodium hyaluronate, dictyophora longifolia extract, rosa desertifolia leaf cell extract and Sargassum dulcificum extract are added, and the synergistic cooperation of sodium ascorbyl phosphate, saccharide isomerides, panthenol, sodium hyaluronate, dictyophora longifolia extract, rosa desertifolia leaf cell extract and Sargassum dulcificum extract is adopted, so that the moisturizing capability of the skin is enhanced by jointly acting on the skin from five dimensions of 'supplement', 'absorb', 'lock', 'solid' and 'strong'.
In a first aspect, the present application provides a moisturizing composition according to the following technical scheme:
a moisturizing composition comprises sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longispa extract, rosa canina leaf cell extract, and Sargassum obtusifolium extract.
In the technical scheme, the moisture is assisted to combine with keratin in the stratum corneum through the excellent skin affinity of the saccharide isomer, so that the moisturizing effect is achieved; the Dictyophora longifolia extract contains rich amino acids, and the saccharide isomers and the Dictyophora longifolia extract are matched with each other to act on the skin surface layer together, so that a good moisturizing effect, namely the 'moisturizing' dimension of the moisturizing composition is achieved on the skin surface layer.
Further, the application promotes the osmotic absorption of the skin to the moisturizing composition by virtue of the structure of the panthenol similar to the sebaceous membrane of the skin, so that the skin can better absorb the active ingredients in the moisturizing composition, namely the 'absorption' dimension of the moisturizing composition.
Furthermore, the application can form a water locking barrier on the surface layer of the skin through the good promotion effect of the gulfweed extract on the activity of the fibroblast, and achieve the good effect of locking the skin moisture, namely the locking dimension of the moisturizing composition through the matching effect of the gulfweed extract and the sodium hyaluronate molecule.
Furthermore, the application can stimulate the moisturizing capability of skin per se through the extract of the desert rose leaf cells and the capability of promoting the synthesis of lipid by the panthenol, and achieves the technical effects of increasing the fluidity of lipid molecules and keratin microfilaments and improving the rigid environment among the cells of the cuticle, namely the solid dimension of the moisturizing composition through the synergistic effect of the extract of the desert rose leaf cells and the panthenol.
Furthermore, the application promotes skin regeneration through the action of sodium ascorbyl phosphate for slowing down skin photodamage, the action of sodium hyaluronate for regulating skin metabolism and promoting cell proliferation and the matching action of sodium ascorbyl phosphate and sodium hyaluronate for promoting skin collagen synthesis, and increases skin thickness, so that skin is moist and elastic, and the water locking capacity of the skin is further enhanced; the natural moisturizing factor in the skin is promoted to be generated by the cooperation of the Dictyophora longispa extract, the desert rose leaf cell extract and the Sargassum dulcis extract; the moisturizing effect of the skin is consolidated by both enhancing skin elasticity and enhancing the natural moisturizing effect of the skin, i.e., the "strong" dimension of the moisturizing composition.
Further, sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longifolia extract, desert rose leaf cell extract and gulfweed extract are added into the moisturizing composition at the same time, and the synergistic cooperation of sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longifolia extract, desert rose leaf cell extract and gulfweed extract is used for jointly acting on the skin from five dimensions of 'supplement', 'absorb', 'lock', 'fix', 'strong', so that the moisturizing capability of the skin is enhanced.
Preferably, the moisturizing composition comprises, by mass, 1% -3% of sodium ascorbyl phosphate, 3% -7% of saccharide isomers, 6% -10% of panthenol, 0.5% -2% of sodium hyaluronate, 1% -3% of dictyophora longifolia extract, 0.5% -2% of desert rose leaf cell extract and 1% -3% of sargassum dulcificum extract, and the balance being solvent.
According to the technical scheme, the dosage ranges of the sodium ascorbyl phosphate, the saccharide isomer, the panthenol, the sodium hyaluronate, the Dictyophora longifolia extract, the desert rose leaf cell extract and the gulfweed extract are limited according to the specific mass percentages, so that the sodium ascorbyl phosphate, the saccharide isomer, the panthenol, the sodium hyaluronate, the Dictyophora longifolia extract, the desert rose leaf cell extract and the gulfweed extract can be better matched in a synergistic manner, the technical effects of 'sucking', 'locking', 'fixing' and 'strengthening' of the moisturizing composition are further improved, and the skin plays a better moisturizing role.
Preferably, the moisturizing composition comprises, by mass, 1% -2% of sodium ascorbyl phosphate, 3% -5% of saccharide isomers, 6% -8% of panthenol, 0.5% -1% of sodium hyaluronate, 1% -2% of dictyophora longifolia extract, 0.5% -1% of desert rose leaf cell extract and 1% -2% of sargassum dulcificum extract, and the balance being solvent.
In the technical scheme, the moisturizing composition better acts on the skin together from five dimensions of 'supplement', 'absorb', 'lock', 'fix', 'strong', and the moisturizing capability of the skin is enhanced by further limiting the dosage ranges of the sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, the Dictyophora longifolia extract, the Rosa desertifolia leaf cell extract and the Sargassum obtusifolia extract
Preferably, the molecular weight of the sodium hyaluronate is 500-1000 daltons.
According to the technical scheme, the sodium hyaluronate with the molecular weight of 500-1000 daltons is selected, so that the sodium hyaluronate can be better attached to the skin, a layer of more stable water locking barrier is formed on the surface layer of the skin, the effect of better locking the skin moisture is achieved, and the lock dimension of the moisturizing composition is further enhanced.
Preferably, the solvent is butanediol.
According to the technical scheme, the butanediol is selected as the solvent of the moisturizing composition, so that sodium ascorbyl phosphate, saccharide isomers, panthenol, sodium hyaluronate, dictyophora longifolia extract, rose leaf cell extract and gulfweed extract are fully dissolved and fully mixed, and the moisturizing composition is enabled to have a more stable system. Further, the butanediol has good moisturizing effect, and can be used as a solvent of the moisturizing composition, and further matched with saccharide isomers and the Dictyophora longifolia extract to act on the skin surface together, so that the skin surface has better moisturizing effect, namely the moisturizing dimension of the moisturizing composition is further enhanced.
In a second aspect, the present application provides a moisturizing composition, which is applied by the following technical scheme:
the use of a moisturizing composition in the manufacture of a cosmetic product.
Preferably, the cosmetic product includes, but is not limited to, a moisturizing essence, a moisturizing lotion, moisturizing water, moisturizing cream.
According to the technical scheme, the moisturizing composition is added into the cosmetics, so that the cosmetics have remarkable moisturizing effect, and the self moisturizing capability of the skin is enhanced.
Preferably, the moisturizing composition is added into the moisturizing essence, and the adding amount of the moisturizing composition is 3-10% based on the mass percentage of the moisturizing essence.
According to the technical scheme, the use amount of the moisturizing composition in moisturizing essence is further limited, so that the moisturizing composition can exert better moisturizing effect in the moisturizing essence, skin can be conditioned well, and the skin has good self moisturizing effect.
In summary, the present application includes at least one of the following beneficial technical effects:
according to the application, through the mutual matching of saccharide isomerides and the Dictyophora longispa extract, the saccharide isomerides and the Dictyophora longispa extract act on the skin surface layer together, so that a good water supplementing effect is achieved on the skin surface layer; the skin can better absorb the effective components in the moisturizing composition by virtue of the similar structure of the panthenol and the sebum membrane of the skin, so that the skin can permeate and absorb the moisturizing composition; the application achieves good effect of locking skin moisture through the coordination of the gulfweed extract and the sodium hyaluronate molecules; the application achieves the technical effects of increasing the fluidity of lipid molecules and keratin microfilaments and improving the rigid environment among cells of the cuticle through the synergistic effect of the desert rose leaf cell extract and panthenol; according to the application, through the coordination of sodium phosphate of anti-hematoacid and sodium hyaluronate, the skin is promoted to be regenerated, the further synthesis of skin collagen is promoted, and through the coordination of the Dictyophora longispa extract, the rose leaf cell extract and the Sargassum blunt extract, the generation of natural moisturizing factors in the skin is promoted; the moisturizing effect of the skin is consolidated by enhancing the skin elasticity and enhancing the natural moisturizing effect of the skin. In conclusion, the application uses sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longifolia extract, desert rose leaf cell extract and Sargassum dull extract to act on the skin together from five dimensions of ' sucking ', ' locking ', ' reinforcing ', and strengthening ' to enhance the moisturizing capability of the skin.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present application, the present application will be further described with reference to the following specific examples.
Example 1
A moisturizing composition comprises 79kg of butanediol, 2kg of sodium ascorbyl phosphate, 5kg of saccharide isomer, 8kg of panthenol, 1kg of sodium hyaluronate, 2kg of Dictyophora longispa extract, 1kg of Rosa canina leaf cell extract, and 2kg of Sargassum obtusifolium extract.
Wherein the panthenol is D-panthenol.
Wherein the molecular weight of the sodium hyaluronate is 880 daltons.
Wherein the Dictyophora longispa extract is purchased from Probiotics Limited of Guizhou family.
Among them, desert rose leaf cell extract is purchased from Ansaibo (Chongqing) biotechnology Co.
Wherein, the gulfweed extract is purchased from qu Shang macro biotechnology Co.
The preparation method of the moisturizing composition comprises the following steps: adding sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longispa extract, desert rose leaf cell extract and Sargassum blunt extract into butanediol, and stirring to obtain the moisturizing composition.
Example 2
A moisturizing composition is different from example 1 in that it comprises 87kg of butanediol, 1kg of sodium ascorbyl phosphate, 3kg of saccharide isomer, 6kg of panthenol, 0.5kg of sodium hyaluronate, 1kg of Dictyophora longifolia extract, 0.5kg of Rosa desertification leaf cell extract, and 1kg of Sargassum blunt extract.
Example 3
A moisturizing composition is different from example 1 in that it comprises 70kg of butanediol, 3kg of sodium ascorbyl phosphate, 7kg of saccharide isomer, 10kg of panthenol, 2kg of sodium hyaluronate, 3kg of Dictyophora longifolia extract, 2kg of Rosa canina leaf cell extract, and 3kg of Sargassum dulcis extract.
Comparative example 1
A moisturizing composition, unlike example 1, includes 84kg of butylene glycol, 2kg of sodium ascorbyl phosphate, 5kg of saccharide isomer, 8kg of panthenol, 1kg of sodium hyaluronate.
Comparative example 2
A moisturizing composition is different from example 1 in that it comprises 95kg of butanediol, 2kg of Dictyophora longispa extract, 1kg of Rosa desertification leaf cell extract, and 2kg of Sargassum blunt extract.
Comparative example 3
A moisturizing composition is different from example 1 in that the Dictyophora longifolia extract is replaced with the same amount.
Comparative example 4
A moisturizing composition is different from example 1 in that the extract of Rosa desertification leaf cells is replaced with the same amount.
Comparative example 5
A moisturizing composition is different from example 1 in that the Sargassum dulcis extract is replaced with the same amount.
Application example 1
A moisturizing concentrate comprising 79.26kg of water, 3kg of glycerin, 5kg of butylene glycol, 0.4kg of ammonium acryloyldimethyl taurate/VP copolymer, 0.04kg of disodium edetate, 1.5kg of PEG/PPG-17/6 copolymer, 0.5kg of p-hydroxyacetophenone, 0.3kg of hexylene glycol, 10kg of a moisturizing composition.
Wherein the moisturizing composition is the moisturizing composition of example 1.
The preparation method of the moisturizing essence comprises the following steps:
step 1: uniformly mixing water, glycerol, butanediol, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer and disodium ethylenediamine tetraacetate, heating to 85 ℃, homogenizing for 10min at 2200r/min, and cooling;
step 2: cooling to 35deg.C, adding hexanediol, PEG/PPG-17/6 copolymer/moisturizing composition under stirring, and stirring at 220r/min for 5min to obtain moisturizing essence.
Application example 2
Unlike application example 1, the moisturizing essence comprises 80.58kg of water, 5kg of glycerin, 8kg of butanediol, 0.6kg of ammonium acryloyldimethyl taurate/VP copolymer, 0.02kg of disodium ethylenediamine tetraacetate, 2kg of PEG/PPG-17/6 copolymer, 0.3kg of p-hydroxyacetophenone, 0.5kg of hexanediol, and 3kg of moisturizing composition.
The preparation method of the moisturizing essence comprises the following steps:
step 1: uniformly mixing water, glycerol, butanediol, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer and disodium ethylenediamine tetraacetate, heating to 80 ℃, homogenizing for 15min at 2000r/min, and cooling;
step 2: cooling to 40deg.C, adding hexanediol, PEG/PPG-17/6 copolymer/moisturizing composition under stirring, and stirring at 200r/min for 8min to obtain moisturizing essence.
Application example 3
Unlike application example 1, the moisturizing composition is the moisturizing composition of example 2.
Application example 4
Unlike application example 1, the moisturizing composition is the moisturizing composition of example 3.
Comparative application example 1
Unlike application example 1, the moisturizing composition is the moisturizing composition of comparative example 1.
Comparative application example 2
Unlike application example 1, the moisturizing composition is the moisturizing composition of comparative example 2.
Comparative application example 3
Unlike application example 1, the moisturizing composition is the moisturizing composition of comparative example 3.
Comparative application example 4
Unlike application example 1, the moisturizing composition is the moisturizing composition of comparative example 4.
Comparative application example 5
Unlike application example 1, the moisturizing composition is the moisturizing composition of comparative example 5.
Comparative application example 6
Unlike application example 1, the moisturizing composition was replaced with water in equal amounts.
Experiment 1
Experimental principle: silk-like proteins (FLGs) can form Natural Moisturizing Factors (NMFs) under the action of caspase-14 (CASP-14), so that the effect of moisturizing compositions on promoting NMF production is verified by measuring the effect of moisturizing compositions on promoting the expression level of CASP-14 mRNA, and the higher the expression level of CASP-14 mRNA, the stronger the effect of moisturizing compositions on promoting NMF production is demonstrated.
Experimental samples: the moisturizing compositions of the above examples and comparative examples.
Experimental materials: human keratinocytes (HaCaT) (Shanghai pacifying practical Co., ltd.), DMEM medium (Thermo Fisher Co., U.S.A.), pureLink total RNA extraction kit (Thermo Fisher Co., U.S.A.), taqMan RNA-to-CT one-step kit (Thermo Fisher Co., U.S.A.), taqMan primers used in fluorescence detection (Thermo Fisher Co., U.S.A.).
The experimental method comprises the following steps: haCaT cells were grown at 3X 10 5 The wells were inoculated in 6-well plates, after 24h incubation, the DMEM broth was removed, the experimental group was added with DMEM broth containing 10% of the experimental sample, and the control group was added with an equal amount of DMEM broth. After further incubation for 24h, total cellular RNA was extracted using the PureLink total RNA extraction kit, and then a real-time fluorescence value (CT) was detected on an ABI7500 real-time fluorescent quantitative PCR instrument using 500ng total RNA as a template according to the TaqMan RNA-to-CT one-step method kit. CAS was calculated from the relative quantification method (Livak method) using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as an internal geneRelative expression level of P-14, - ΔΔCT= (CT) CASP-14 －CT GAPDH ) Experimental group －(CT CASP-14 －CT GAPDH ) Control group Relative expression level=2 -ΔΔCT 。
The experimental results are shown in Table 1.
Table 1:
in combination with examples 1 to 3, comparative examples 1 to 5 and Table 1, it is apparent that the combination of Dictyophora longispa extract, rosa desertifolia leaf cell extract and Sargassum obtusifolium extract has a promoting effect on the expression level of mRNA of CASP-14, and that the increase of the expression level of mRNA of CASP-14 means that more silk fibroin is decomposed into amino acids under the action of CASP-14 to form natural moisturizing factors, means that the ability of natural moisturizing factors produced by skin is enhanced, and means that skin has a better self moisturizing ability.
In combination with example 1, comparative examples 1 to 2 and Table 1, it is apparent that the moisturizing composition has a better synergistic effect by further adding sodium ascorbyl phosphate, saccharide isomer, panthenol and sodium hyaluronate based on the combination of the Dictyophora longispa extract, the Rosa desertifolia leaf cell extract and the Sargassum dulcificum extract, and can further promote the promotion of the expression level of mRNA of CASP-14 by the Dictyophora longispa extract, the Rosa desertifolia leaf cell extract and the Sargassum dulcificum extract, and further enhance the moisturizing ability of the skin itself.
Experiment 2
Experimental samples: moisture retention essence of each application example and comparative application example is provided.
100 dry skin experimental persons are selected, the faces of the experimental persons are dry due to perennial lack of water and accompanied by dry fine lines, the ages of the experimental persons are 26-35 years, the skin is free from burn, allergic diseases and systemic diseases, the experimental persons are not subjected to skin beauty treatment in the last three months, and hormone medicines are not taken. The experimenters were equally divided into 10 groups of 10 persons each.
Experimental principle: the SCH value represents how much moisture is retained by the skin, the higher the SCH value represents the higher moisture content of the skin, the SCH value for normal skin is >30 (a.u.), the SCH value for dry skin is <30 (a.u.), and the moisturizing ability of the moisturizing composition is verified by the SCH values of the skin for each time period.
The experimental method comprises the following steps: the experimenter insists on normal use of the experimental sample after cleaning the face in the morning and evening, and no other skin care products are used in the period. The use was continued for 28 days.
On day 1 of the application, a 5cm x 5cm area was selected on the left cheek of each experimenter and the initial SCH value of the area was measured using the Courage & Khazaka, cologne, german-ny. The SCH values of the test areas were then measured at 0.5h, 1h, 3h, 6h, 9h, and 12h after application, and the test results were recorded in Table 2 and averaged for each group.
On day 28 of application, the initial SCH values of the experimental zone of day 28 and the SCH values of the experimental zones of 0.5h, 1h, 3h, 6h, 9h, 12h after application were detected with reference to the test method on day 1 of application, the test results were recorded in table 2, and the average values of the respective groups were taken.
Table 2:
in combination with application examples 1 to 4, comparative application examples 1 to 6, and the initial SCH values of Table 2, it is apparent that application examples 1 to 4 have excellent effects of enhancing skin self-moisturizing ability. The specific analysis shows that the skin moisturizing agent can achieve the effect of obviously enhancing the moisturizing ability of the skin only by the synergistic combination of seven substances, namely sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longispa extract, desert rose leaf cell extract and Sargassum blunt extract, and the five dimensions of 'sucking', 'locking', 'fixing', 'strong'.
In combination with application example 1, comparative examples 1 to 5 and Table 2, it is apparent that the synergistic combination of seven substances, namely SCH value >30 at 9h on day 1 and SCH value >30 at 12h on day 28, of application example 1 and SCH value >30 on day 28, namely the continuous use of the moisturizing essence of application example 1 for 28 days can not only enhance the moisturizing ability of skin, but also nourish dry skin well, condition the moisture content in dry skin to a normal range, and fundamentally solve the problem of dry skin water deficiency, thereby solving the problem of water deficiency of dry skin by the synergistic combination of seven substances, namely sodium ascorbyl phosphate, saccharide isomer, panthenol, sodium hyaluronate, dictyophora longifolia extract, rosa leaf cell extract and Sargassum maculatum extract, can not only enhance the moisturizing ability of skin, but also nourish and condition dry skin.
The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.
Claims (8)
1. A moisturizing composition is characterized by comprising sodium ascorbyl phosphate, saccharide isomers, panthenol, sodium hyaluronate, dictyophora longispa extract, a rose leaf cell extract and a gulfweed extract.
2. The moisturizing composition of claim 1, wherein the moisturizing composition comprises, by mass, 1% -3% of sodium ascorbyl phosphate, 3% -7% of saccharide isomers, 6% -10% of panthenol, 0.5% -2% of sodium hyaluronate, 1% -3% of dictyophora longifolia extract, 0.5% -2% of desert rose leaf cell extract and 1% -3% of gulfweed extract, and the balance being a solvent.
3. The moisturizing composition of claim 1, wherein the moisturizing composition comprises, by mass, 1% -2% of sodium ascorbyl phosphate, 3% -5% of saccharide isomers, 6% -8% of panthenol, 0.5% -1% of sodium hyaluronate, 1% -2% of dictyophora longifolia extract, 0.5% -1% of desert rose leaf cell extract and 1% -2% of gulfweed extract, and the balance being a solvent.
4. The moisturizing composition of claim 1, wherein the sodium hyaluronate has a molecular weight of 500 to 1000 daltons.
5. A moisturizing composition in accordance with claim 1, wherein the solvent is butylene glycol.
6. Use of a moisturizing composition according to any one of claims 1 to 5, wherein it is incorporated into a cosmetic product.
7. The use of a moisturizing composition as in claim 6 wherein the cosmetic product includes, but is not limited to, moisturizing essences, moisturizing lotions, moisturizing waters, moisturizing creams.
8. The use of a moisturizing composition according to claim 7, wherein the moisturizing composition is added to the moisturizing essence in an amount of 3% -10% by mass of the moisturizing essence.
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