CN116964044B - 乙酰胺基-苯基四唑衍生物及其使用方法 - Google Patents
乙酰胺基-苯基四唑衍生物及其使用方法Info
- Publication number
- CN116964044B CN116964044B CN202180079852.2A CN202180079852A CN116964044B CN 116964044 B CN116964044 B CN 116964044B CN 202180079852 A CN202180079852 A CN 202180079852A CN 116964044 B CN116964044 B CN 116964044B
- Authority
- CN
- China
- Prior art keywords
- heteroatoms selected
- substituted
- membered
- optionally substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063088788P | 2020-10-07 | 2020-10-07 | |
| US63/088,788 | 2020-10-07 | ||
| PCT/US2021/053937 WO2022076663A1 (en) | 2020-10-07 | 2021-10-07 | Acetamido-phenyltetrazole derivatives and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116964044A CN116964044A (zh) | 2023-10-27 |
| CN116964044B true CN116964044B (zh) | 2026-03-06 |
Family
ID=78483546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180079852.2A Active CN116964044B (zh) | 2020-10-07 | 2021-10-07 | 乙酰胺基-苯基四唑衍生物及其使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11739089B2 (https=) |
| EP (1) | EP4225747A1 (https=) |
| JP (1) | JP7823036B2 (https=) |
| KR (1) | KR20230104151A (https=) |
| CN (1) | CN116964044B (https=) |
| AU (1) | AU2021358074A1 (https=) |
| CA (1) | CA3194694A1 (https=) |
| IL (1) | IL301516A (https=) |
| MX (1) | MX2023003933A (https=) |
| TW (1) | TWI900672B (https=) |
| WO (1) | WO2022076663A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| CN110312130B (zh) * | 2019-06-25 | 2021-10-15 | 浙江大华技术股份有限公司 | 基于三角模式的帧间预测、视频编码方法及设备 |
| TWI900672B (zh) | 2020-10-07 | 2025-10-11 | 香港商希華醫藥有限公司 | 乙醯胺基－苯基四唑衍生物及其使用方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1863795A (zh) * | 2003-10-07 | 2006-11-15 | 韩美药品株式会社 | P－糖蛋白抑制剂,其制备方法和包括该抑制剂的药物组合物 |
| CN102812020A (zh) * | 2010-01-15 | 2012-12-05 | 韩美科学株式会社 | 用于制备四唑甲磺酸盐的方法及其使用的新化合物 |
| CN104870443A (zh) * | 2012-12-13 | 2015-08-26 | 韩美药品株式会社 | 具有改善的溶解度的包含四唑衍生物作为活性成分的固体分散体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5663179A (en) | 1992-07-10 | 1997-09-02 | Laboratoires Glaxo Sa | Certain isoquinoline derivatives having anti-tumor properties |
| US5763263A (en) | 1995-11-27 | 1998-06-09 | Dehlinger; Peter J. | Method and apparatus for producing position addressable combinatorial libraries |
| GB9717576D0 (en) | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| WO2015152433A1 (en) | 2014-03-31 | 2015-10-08 | Hanmi Pharm. Co., Ltd. | Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same |
| KR102293907B1 (ko) | 2015-06-30 | 2021-08-26 | 한미약품 주식회사 | 이리노테칸 함유 경구용 고형제제 및 그 제조방법 |
| TWI838700B (zh) | 2015-09-30 | 2024-04-11 | 香港商慧源香港創新有限公司 | 口服紫杉烷組合物及方法 |
| TWI833710B (zh) | 2017-10-06 | 2024-03-01 | 香港商慧源香港創新有限公司 | 高單位含量口服型紫杉烷組合物及方法 |
| TWI900672B (zh) | 2020-10-07 | 2025-10-11 | 香港商希華醫藥有限公司 | 乙醯胺基－苯基四唑衍生物及其使用方法 |
-
2021
- 2021-10-07 TW TW110137339A patent/TWI900672B/zh active
- 2021-10-07 US US17/495,935 patent/US11739089B2/en active Active
- 2021-10-07 AU AU2021358074A patent/AU2021358074A1/en active Pending
- 2021-10-07 MX MX2023003933A patent/MX2023003933A/es unknown
- 2021-10-07 CA CA3194694A patent/CA3194694A1/en active Pending
- 2021-10-07 WO PCT/US2021/053937 patent/WO2022076663A1/en not_active Ceased
- 2021-10-07 KR KR1020237015140A patent/KR20230104151A/ko active Pending
- 2021-10-07 EP EP21801761.4A patent/EP4225747A1/en active Pending
- 2021-10-07 JP JP2023521299A patent/JP7823036B2/ja active Active
- 2021-10-07 CN CN202180079852.2A patent/CN116964044B/zh active Active
- 2021-10-07 IL IL301516A patent/IL301516A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1863795A (zh) * | 2003-10-07 | 2006-11-15 | 韩美药品株式会社 | P－糖蛋白抑制剂,其制备方法和包括该抑制剂的药物组合物 |
| CN102812020A (zh) * | 2010-01-15 | 2012-12-05 | 韩美科学株式会社 | 用于制备四唑甲磺酸盐的方法及其使用的新化合物 |
| CN104870443A (zh) * | 2012-12-13 | 2015-08-26 | 韩美药品株式会社 | 具有改善的溶解度的包含四唑衍生物作为活性成分的固体分散体 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230104151A (ko) | 2023-07-07 |
| MX2023003933A (es) | 2023-07-05 |
| EP4225747A1 (en) | 2023-08-16 |
| US11739089B2 (en) | 2023-08-29 |
| WO2022076663A1 (en) | 2022-04-14 |
| CN116964044A (zh) | 2023-10-27 |
| IL301516A (en) | 2023-05-01 |
| AU2021358074A1 (en) | 2023-04-27 |
| CA3194694A1 (en) | 2022-04-14 |
| JP2023544615A (ja) | 2023-10-24 |
| TW202233593A (zh) | 2022-09-01 |
| TWI900672B (zh) | 2025-10-11 |
| JP7823036B2 (ja) | 2026-03-03 |
| US20220106312A1 (en) | 2022-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Country or region after: Hong-Kong Address after: 1st Floor, 3 Xuri Street, To Kwa Wan, Kowloon, Hong Kong, China Applicant after: Xihua Pharmaceutical Co.,Ltd. Address before: Room 1535, Central Building, 1-3 Pedder Street, Hong Kong, China Applicant before: Xihua Pharmaceutical Co.,Ltd. Country or region before: Hong-Kong |
|
| CB02 | Change of applicant information | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20250730 Address after: Unit 210A, 2/F, Building 5W, 5 Science and Technology Avenue West, Hong Kong Science Park, Shatin, Hong Kong, China Applicant after: Xihua Pharmaceutical Hong Kong Ltd. Country or region after: Hongkong, China Address before: Hongkong, China 1st Floor, 3 Xuri Street, To Kwa Wan, Kowloon Applicant before: Xihua Pharmaceutical Co.,Ltd. Country or region before: Hongkong, China |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |