CN116888136A - 寡核苷酸的制备方法 - Google Patents

寡核苷酸的制备方法 Download PDF

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Publication number
CN116888136A
CN116888136A CN202280014458.5A CN202280014458A CN116888136A CN 116888136 A CN116888136 A CN 116888136A CN 202280014458 A CN202280014458 A CN 202280014458A CN 116888136 A CN116888136 A CN 116888136A
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CN
China
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substituted
group
compound
ring
alkyl
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Pending
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CN202280014458.5A
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English (en)
Chinese (zh)
Inventor
早川敦彦
市丸泰介
井上聪
高桥大辅
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of CN116888136A publication Critical patent/CN116888136A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280014458.5A 2021-02-12 2022-02-10 寡核苷酸的制备方法 Pending CN116888136A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021021175 2021-02-12
JP2021-021175 2021-02-12
PCT/JP2022/005362 WO2022172994A1 (ja) 2021-02-12 2022-02-10 オリゴヌクレオチドの製造方法

Publications (1)

Publication Number Publication Date
CN116888136A true CN116888136A (zh) 2023-10-13

Family

ID=82838358

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280014458.5A Pending CN116888136A (zh) 2021-02-12 2022-02-10 寡核苷酸的制备方法

Country Status (5)

Country Link
US (1) US20240018180A1 (https=)
EP (1) EP4293035A4 (https=)
JP (1) JPWO2022172994A1 (https=)
CN (1) CN116888136A (https=)
WO (1) WO2022172994A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024089953A1 (ja) * 2022-10-27 2024-05-02 住友化学株式会社 オリゴヌクレオチドの製造方法
WO2026062247A1 (en) 2024-09-20 2026-03-26 Astrazeneca Ab Liquid-phase oligonucleotide synthesis using 2-(2-nitrophenyl)propyloxycarbonyl (nppoc) as a protecting group

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548942A (en) * 1982-11-26 1985-10-22 Societe Anonyme Dite: L'oreal Anti-acne use of derivatives of (5,4b)-isothiazolo pyridine-3-one
CN103232842A (zh) * 2013-04-15 2013-08-07 山东大学 一种基于聚集诱导荧光增强材料的亚硫酸氢根离子的荧光探针及快速检验试纸
CN103298823A (zh) * 2010-06-30 2013-09-11 集润德斯股份公司 一种使用n-硫代化合物用于寡核苷酸合成的新方法
WO2019126567A1 (en) * 2017-12-22 2019-06-27 Southern Research Institute Substituted heterocyclic-pyridinones as hiv-1 nef-hck inhibitors

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
JPS5239037B2 (https=) * 1971-06-15 1977-10-03
JPS49109385A (https=) * 1973-03-03 1974-10-17
JPH0787982A (ja) * 1993-01-29 1995-04-04 Sankyo Co Ltd 修飾オリゴデオキシリボヌクレオチド
JPH0892275A (ja) * 1994-07-25 1996-04-09 Sankyo Co Ltd 修飾オリゴデオキシリボヌクレオチド
WO2013017469A1 (en) * 2011-07-29 2013-02-07 Girindus America, Inc. Sulfurization reagents on solid supports
CN113717239B (zh) 2015-01-21 2024-12-24 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
CN116063365A (zh) 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
WO2019131719A1 (ja) 2017-12-27 2019-07-04 神戸天然物化学株式会社 高脂溶性ホスホラミダイトの製造
JP7393807B2 (ja) 2019-05-21 2023-12-07 株式会社ナティアス オリゴヌクレオチド合成に用いるマルチフルオラスブロックマーおよびこれを用いたオリゴヌクレオチド合成方法
JP7153928B2 (ja) 2019-07-30 2022-10-17 株式会社サンエス メッシュベスト
EP4006045A4 (en) 2019-08-29 2022-10-19 FUJIFILM Corporation METHOD FOR PRODUCTION OF A NUCLEIC ACID COMPOUND AND NUCLEIC ACID COMPOUND
US20240092821A1 (en) 2020-03-31 2024-03-21 Janssen Biopharma, Inc. Synthesis of oligonucleotides and related compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548942A (en) * 1982-11-26 1985-10-22 Societe Anonyme Dite: L'oreal Anti-acne use of derivatives of (5,4b)-isothiazolo pyridine-3-one
CN103298823A (zh) * 2010-06-30 2013-09-11 集润德斯股份公司 一种使用n-硫代化合物用于寡核苷酸合成的新方法
CN103232842A (zh) * 2013-04-15 2013-08-07 山东大学 一种基于聚集诱导荧光增强材料的亚硫酸氢根离子的荧光探针及快速检验试纸
WO2019126567A1 (en) * 2017-12-22 2019-06-27 Southern Research Institute Substituted heterocyclic-pyridinones as hiv-1 nef-hck inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GANGIREDDY, PAVANKUMAR ET AL.: "Mechanism of Acylative Oxidation-Reduction-Condensation Reactions Using Benzoisothiazolones as Oxidant and Triethylphosphite as Stoichiometric Reductant", 《 JOURNAL OF ORGANIC CHEMISTRY》, vol. 82, no. 7, 27 February 2017 (2017-02-27), pages 3513 - 3529 *
RYUUYA TAWARADA ET AL.: "Mechanistic studies on oxidative condensation of a thymidine 3\'-H-phosphonate derivative with 3\'-O-acetylthymidine", 《ARKIVOC》, 31 December 2009 (2009-12-31), pages 264 - 273 *

Also Published As

Publication number Publication date
JPWO2022172994A1 (https=) 2022-08-18
EP4293035A1 (en) 2023-12-20
WO2022172994A1 (ja) 2022-08-18
US20240018180A1 (en) 2024-01-18
EP4293035A4 (en) 2025-03-05

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