CN116870982A - Automatic comprehensive treatment device for tubular container - Google Patents
Automatic comprehensive treatment device for tubular container Download PDFInfo
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- CN116870982A CN116870982A CN202311044657.3A CN202311044657A CN116870982A CN 116870982 A CN116870982 A CN 116870982A CN 202311044657 A CN202311044657 A CN 202311044657A CN 116870982 A CN116870982 A CN 116870982A
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- 239000002699 waste material Substances 0.000 claims abstract description 57
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 238000003860 storage Methods 0.000 claims abstract description 37
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 32
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 9
- 230000007246 mechanism Effects 0.000 claims description 18
- 238000012545 processing Methods 0.000 claims description 5
- 239000002912 waste gas Substances 0.000 claims description 3
- 238000002474 experimental method Methods 0.000 abstract description 22
- 230000009471 action Effects 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 12
- 230000008569 process Effects 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 description 21
- 239000011324 bead Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 206010063385 Intellectualisation Diseases 0.000 description 4
- 238000007664 blowing Methods 0.000 description 4
- 238000007599 discharging Methods 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000011091 antibody purification Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/0227—Details of motor drive means
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/0275—Interchangeable or disposable dispensing tips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/54—Supports specially adapted for pipettes and burettes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to an automatic comprehensive treatment device for a tubular container, which comprises a rack, and a workbench surface, a pipetting module and a control module which are arranged on the rack; the workbench surface is provided with a plurality of reagent placement boxes, gun head storage modules, centrifuge tube function modules, gun head waste ports, waste liquid discharge ports and sample collection boxes, wherein the centrifuge function modules are used for realizing rotation, magnetic attraction, heating and/or drying of centrifuge tubes; the pipetting module comprises one or more of a single-channel pipetting device or a multi-channel pipetting device, and the single-channel pipetting device or the multi-channel pipetting device is used for pipetting, draining liquid, pipetting among modules or stirring and blowing-sucking a centrifuge tube; the control module is used for controlling the action of the pipetting module and the centrifuge tube functional module. The tubular container automatic comprehensive treatment device can select one or more groups of centrifuge tube functional modules and pipetting modules according to the complexity of biological experiments, and an automatic complex biological experiment process is realized.
Description
Technical Field
The invention relates to an automatic comprehensive treatment device for a tubular container, and belongs to the field of experimental instruments.
Background
In the laboratory, the use of tubular sample containers (mostly centrifuge tubes) is very common and an essential laboratory tool. The tubular sample container has very wide application, and an experimenter can finish various treatment requirements of centrifugation, heating, uniform mixing, sample adding, reaction, magnetic bead adsorption and the like of a reagent or a sample in the tubular sample container. The above-mentioned processing can be done manually or by related devices. But these devices are now all stand alone. During the operation, the experimenter needs to use different equipment (such as a pipette gun, a centrifuge, a magnetic rack, a water bath kettle, a vortex oscillator and the like), and the experimenter participates in the test procedure manually in the whole process. This requires the experimenter to keep track of the methods of operation of the various experimental facilities and the steps of operation of the different experimental procedures, with high demands on experimental literacy. In the aspects of economy and practicability, the equipment not only occupies test expenses and a large amount of manpower and material resources, but also has the problems of occupied space, high later maintenance cost and the like.
With the increasing progress of technology and the increasing laboratory demands, laboratory automation equipment is becoming more and more widely used. However, a large number of laboratory automation devices are nowadays only aimed at well-plate type containers, not the most commonly used tubular sample containers in the laboratory. For this purpose, we develop the full-automatic tubular sample container comprehensive treatment device with full-process and multiple functions. The device can be applied to a plurality of experimental flows such as plasmid extraction, nucleic acid extraction, protein and antibody purification and the like. The laboratory automation level is greatly improved, the working intensity and difficulty of an experimenter are reduced, and the biological experiment efficiency is improved.
Disclosure of Invention
Aiming at the problems, the invention aims to provide the tubular container automatic comprehensive treatment device which integrates multiple functions and can be edited and used according to the needs, and the tubular container automatic comprehensive treatment device can realize modularization, integration and intellectualization while meeting the operation of multiple test procedures, and solves the problems of low operation efficiency, time and labor waste and occupation of laboratory staff of the tubular sample container in the laboratory.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the invention provides an automatic comprehensive treatment device for a tubular container, which comprises a rack, and a workbench surface, a pipetting module and a control module which are arranged on the rack;
the device comprises a workbench surface, a plurality of reagent placing boxes, a gun head storage module, a centrifuge tube functional module, a gun head waste port, a waste liquid discharge port and a sample collection box, wherein a plurality of reagent bottles are stored in the reagent placing boxes, a plurality of gun heads are stored in the gun head storage module, the centrifuge tube functional module is used for realizing rotation, magnetic attraction, heating and/or drying of a centrifuge tube, a collection pipe is arranged in the sample collection box, and a sample is stored in the collection pipe;
the pipetting module comprises one or more of a single-channel pipetting device or a multi-channel pipetting device, the pipetting module is positioned above the workbench surface, and the single-channel pipetting device or the multi-channel pipetting device is used for pipetting, draining liquid, pipetting among the modules or stirring and blowing-sucking a centrifuge tube;
the control module is electrically connected with the pipetting module and the centrifuge tube functional module and used for controlling the pipetting module and the centrifuge tube functional module to act.
Further, the pipetting module further comprises an X-axis linear module, a Y-axis linear module, a first Z-axis linear module and a second Z-axis linear module, the single-channel pipetting device is connected with the first Z-axis linear module, the multi-channel pipetting device is connected with the second Z-axis linear module, the first Z-axis linear module is connected with the Y-axis linear module, the second Z-axis linear module is connected with the X-axis linear module, and the Y-axis linear module is connected with the X-axis linear module.
Further, the anti-drip device comprises an anti-drip plate and a first driving mechanism used for driving the anti-drip plate to move, the anti-drip plate is connected with the first driving mechanism, and the first driving mechanism is used for driving the anti-drip plate to the lower part of the gun head.
Further, a waterproof board is arranged at the bottom of the reagent placement box.
Further, the gun head storage module comprises a gun head storage box, the gun head storage box comprises an upper-layer clamping plate and a lower-layer connecting plate, the upper-layer clamping plate is fixed on the lower-layer connecting plate, the lower-layer connecting plate is connected with the bottom plate in a sliding manner, the gun head storage box moves along the Y-axis direction of the bottom plate, and the gun head is clamped on the upper-layer clamping plate.
Further, the gun head storage module further comprises a second driving mechanism for controlling the gun head storage box to move along the Y-axis direction of the bottom plate, the second driving mechanism is electrically connected with the control module, and the control module controls the second driving mechanism to act.
Further, the lower part of the gun head waste gas port is communicated with a waste gun head collecting box, the lower part of the waste liquid discharge port is communicated with a waste liquid collecting box, and the waste liquid collecting box and the waste gun head collecting box are both in sliding connection with the bottom plate and supported by the bottom plate.
Further, the waste liquid collecting box and the waste gun head collecting box are the same collecting box, and a waste liquid collecting cavity and a waste gun head collecting cavity are formed in the same collecting box.
Due to the adoption of the technical scheme, the invention has the following advantages:
the centrifuge tube functional module can realize functions of rotation, magnetic attraction, heating (drying) and the like, the pipetting module can realize functions of liquid suction and liquid discharge, the pipetting module and the pipetting module cooperate to act, a conventional centrifuge tube is taken as a main container, and the pipetting module cooperates with a gun head storage module, a gun head waste port, a waste liquid discharge port, a sample collection box and other modules, so that the centrifuge tube functional module can realize, but is not limited to: the method comprises the steps of gun head taking, gun head discarding, liquid adding, liquid discharging, liquid transferring, sample collecting, multi-mode uniform mixing, magnetic bead adsorption, solution heating, magnetic bead drying (or airing) and the like, and the actions are reasonably combined according to experimental procedures, so that the full automatic procedures of biological experiments can be realized.
The equipment adopts modularized design, can select one or more sets of centrifuging tube functional module and pipetting module according to biological experiment complexity, realizes automatic complicated biological experiment process, and simultaneously, this scheme also can extend to on the production line, and the combination of different modules improves automation level and production efficiency.
The centrifuging tube functional module cooperates with the pipetting module, can realize multiple and mix the even action, for example: blow-suction mixing (pipetting module sucking and discharging action), stirring mixing (pipetting module moving stirring, centrifuge tube function module fixing or pipetting module fixing, centrifuge tube function module rotating or combined action of the pipetting module and the centrifuge tube function module), rotating mixing (centrifuge tube function module rotating). According to actual demands, different biological experiment flows can select different mixing modes or combinations of different mixing modes, so that the optimal mixing effect is realized, and the optimal biological experiment result is finally obtained.
The comprehensive treatment device can integrate multiple functions and edit and use the tubular sample container automatically and comprehensively according to needs, and can realize modularization, integration and intellectualization while meeting the operation of multiple test flows, so that the problems of low operation efficiency, time and labor waste and occupation of laboratory personnel of the tubular sample container in the laboratory are solved.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Like parts are designated with like reference numerals throughout the drawings.
In the drawings:
FIG. 1 is a schematic view of the structure of an automated integrated treatment device for tubular containers;
FIG. 2 is a front view of an automated integrated tubular container handling apparatus;
FIG. 3 is a top view of the work surface;
FIG. 4 is a side view of the automated integrated tubular container handling apparatus;
fig. 5 is a schematic structural view of the gun head storage module.
Detailed Description
Exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
The invention provides an automatic comprehensive treatment device for a tubular container, which comprises a rack, and a workbench surface, a pipetting module and a control module which are arranged on the rack; the device comprises a workbench surface, a plurality of reagent placing boxes, a gun head storage module, a centrifuge tube functional module, a gun head waste port, a waste liquid discharge port and a sample collection box, wherein a plurality of reagent bottles are stored in the reagent placing boxes, a plurality of gun heads are stored in the gun head storage module, the centrifuge tube functional module is used for realizing rotation, magnetic attraction, heating and/or drying of a centrifuge tube, a collection pipe is arranged in the sample collection box, and a sample is stored in the collection pipe; the pipetting module comprises one or more of a single-channel pipetting device or a multi-channel pipetting device, the pipetting module is positioned above the rack, and the single-channel pipetting device or the multi-channel pipetting device is used for pipetting, draining liquid, pipetting among the modules or stirring and blowing-sucking a centrifuge tube; the control module is electrically connected with the pipetting module and the centrifuge tube functional module and used for controlling the pipetting module and the centrifuge tube functional module to act. The automatic comprehensive treatment device for the tubular sample container can integrate multiple functions and edit the tubular sample container according to needs, can realize modularization, integration and intellectualization while meeting the operation of multiple test flows, and solves the problems of low operation efficiency, time and labor waste and occupation of laboratory staff of the tubular sample container in the laboratory.
As shown in fig. 1 to 5, an embodiment of the present invention provides an automated integrated processing apparatus 1 for a tubular container, comprising a frame 1, and a table top 12, a pipetting module 2 and a control module mounted on the frame 11; the workbench surface 12 is provided with a plurality of reagent placement boxes 3, a gun head storage module 4, a centrifuge tube functional module 5, a gun head waste port 6, a waste liquid discharge port 7 and a sample collection box 8, wherein a plurality of reagent bottles are stored in the reagent placement boxes 3, a plurality of gun heads are stored in the gun head storage module 4, the centrifuge functional module 5 is used for realizing rotation, magnetic attraction, heating and/or drying of a centrifuge tube, a collection pipe is used for placing in the sample collection box 3, and a sample is stored in the collection pipe; the pipetting module 2 comprises one or more of a single-channel pipetting device 21 or a multi-channel pipetting device 22, the pipetting module 2 is positioned above the workbench 12, and the single-channel pipetting device 21 or the multi-channel pipetting device 22 is used for pipetting, draining liquid, pipetting between modules or stirring and blowing-sucking centrifugal tubes; the control module is electrically connected with the pipetting module 2 and the centrifuge tube functional module 5 and is used for controlling the pipetting module 2 and the centrifuge tube functional module 5 to act.
The centrifuge tube functional module can realize functions of rotation, magnetic attraction, heating (drying) and the like, the pipetting module can realize functions of liquid suction and liquid discharge, the pipetting module and the pipetting module cooperate to act, a conventional centrifuge tube is taken as a main container, and the pipetting module cooperates with a gun head storage module, a gun head waste port, a waste liquid discharge port, a sample collection box and other modules, so that the centrifuge tube functional module can realize, but is not limited to: the method comprises the steps of gun head taking, gun head discarding, liquid adding, liquid discharging, liquid transferring, sample collecting, multi-mode uniform mixing, magnetic bead adsorption, solution heating, magnetic bead drying (or airing) and the like, and the actions are reasonably combined according to experimental procedures, so that the full automatic procedures of biological experiments can be realized.
The equipment adopts the modularized design, can select one or more sets of centrifuging tube functional module 5 and pipetting module 2 according to biological experiment complexity, realize automatic complicated biological experiment process, simultaneously, this scheme also can extend to on the production line, the combination of different modules improves automation level and production efficiency.
The centrifuge tube functional module 5 cooperates with the pipetting module 2, and can realize various mixing actions, such as: blow-suction mixing (pipetting module sucking and discharging action), stirring mixing (pipetting module moving stirring, centrifuge tube functional module fixing or pipetting module fixing, centrifuge tube functional module rotating or combined action of the pipetting module and the centrifuge tube functional module), rotating mixing (centrifuge tube functional module rotating). According to actual demands, different biological experiment flows can select different mixing modes or combinations of different mixing modes, so that the optimal mixing effect is realized, and the optimal biological experiment result is finally obtained.
The comprehensive treatment device can integrate multiple functions and edit and use the tubular sample container automatically and comprehensively according to needs, and can realize modularization, integration and intellectualization while meeting the operation of multiple test flows, so that the problems of low operation efficiency, time and labor waste and occupation of laboratory personnel of the tubular sample container in the laboratory are solved.
The pipetting module 2 further comprises an X-axis linear module, a Y-axis linear module, a first Z-axis linear module and a second Z-axis linear module, wherein the single-channel pipetting device is connected with the first Z-axis linear module, the multi-channel pipetting device is connected with the second Z-axis linear module, the first Z-axis linear module is connected with the Y-axis linear module, the second Z-axis linear module is connected with the X-axis linear module, and the Y-axis linear module is connected with the X-axis linear module.
The multichannel pipettor 22 may specifically be a 12-channel multichannel pipettor.
The pipetting module 2 comprises two pipettes, namely a single-channel pipetter 21 and a 12-channel pipetter 22. Can realize the functions of adding, stirring, blowing and sucking, transferring reagent and the like. Wherein, the single-channel pipettor 21 and the multi-channel pipettor 22 are mainly used for sucking the reagent from the reagent bottle and placing the reagent into a centrifuge tube, including eluent, rinsing liquid, lysate and the like; when some easily-precipitated reagents such as magnetic beads are added, operations such as blowing, sucking and mixing, stirring a centrifuge tube, blowing and sucking, inter-module pipetting, waste liquid draining and the like can be performed. The two pipettes are arranged in parallel when seen from the front. The 12 channel pipette 22 is on the right side and the single channel pipette 21 is on the left side. The two pipettes share the X axis; the single-channel pipettor can move along the Y axis and the Z axis; the 12-channel pipette 22 has only Z-axis motion and no Y-axis motion.
The automatic comprehensive treatment device for the tubular container further comprises an anti-dripping device (not shown in the figure), wherein the anti-dripping device comprises an anti-dripping plate and a first driving mechanism used for driving the anti-dripping plate to move, the anti-dripping plate is connected with the first driving mechanism, and the first driving mechanism is used for driving the anti-dripping plate to the lower part of the gun head. The drip-proof plate is used for preventing the gun head from leaking. The movement of the single channel pipettes 21 and 12 channel pipettes 22 is not affected when not in operation. When the gun head on the pipette has liquid and moves on the working table 12, the drip guard moves below the gun head and moves along with the gun head, so that dripping is avoided.
As shown in fig. 3, the working table 12 is a flat plate, and the flat plate is sequentially provided with a reagent placement box 3, a gun head storage module 4, a centrifuge tube functional module 5, a gun head waste port 6, a waste liquid discharge port 7 and a sample collection box 8 from the right, a plurality of reagent bottles are stored in the reagent placement box 3, and a plurality of gun heads are stored in the gun head storage module 4. Wherein the centrifuge tube functional module is fixed on the flat plate. The bottom of the reagent placement box 3 is provided with a waterproof board to prevent water leakage and electricity leakage. The table top is a main operation platform for experimenters. During biological test operation, the preparation stage is carried out before the experiment is started: the experimenter puts corresponding quantity of gun heads into the gun head storage module 4 according to the needs, the reagent bottles required to be used are put into the reagent placement box, the sample tube is put into the corresponding position of the centrifuge tube functional module 5, and the sample collection tube is put into the sample collection box 8. After the experiment is finished, the experimenter takes out the sample collecting pipe.
The reagent placement box 3 has various manufacturing processes, and can be mechanically added, 3D printed and the like. The reagent bottles in the reagent placement kit 3 can be used for placing different kinds of reagents according to the requirements of biological experiment procedures. Meanwhile, the placement positions can be changed, and different patterns are designed according to requirements. The desk top and the reagent placing box are designed in a clamping groove type, so that the replacement is convenient.
The gun head storage module 4 comprises a gun head storage box, the gun head storage box comprises an upper-layer clamping plate and a lower-layer connecting plate, the upper-layer clamping plate is fixed on the lower-layer connecting plate, the lower-layer connecting plate is connected with the bottom plate in a sliding manner, the gun head storage box moves along the Y-axis direction of the bottom plate, and the gun head is clamped on the upper-layer clamping plate.
As shown in fig. 5, the gun head storage module 4 includes a gun head storage box, the gun head storage box includes an upper clamping plate 41 and a lower connecting plate 42, the upper clamping plate 41 is fixed on the lower connecting plate 42, the lower connecting plate 42 is slidably connected with the bottom plate 13, and moves along the Y-axis direction of the bottom plate 13, and the gun head is clamped on the upper clamping plate 41. The gun head storage module 4 further comprises a second driving mechanism for controlling the gun head storage box to move along the Y-axis direction of the bottom plate, the second driving mechanism is electrically connected with the control module, and the control module controls the second driving mechanism to act.
The gun head of the pipetting module 2 can be moved by the pipetting module 2 or by the gun head storage box or by the two, and finally the function of accurately inserting and picking the gun head is realized.
The centrifuge tube functional module 5 mainly has the functions of rotating and uniformly mixing, temperature control and heating, magnetic bead adsorption and the like. The functional modules can be selected and matched at will according to the biological experiment flow, and the functional modules with different numbers can be selected. The detailed description of the functions can be found in patent 202211353904.3, and the structure and use cases of the functional modules are described in sufficient detail.
The sample collection cartridge 8 is used to house a collection tube. The sample collection cartridge 8 can be designed according to the requirements and placed with a 1.5ml-5ml collection tube. Meets the requirements of different biological experiments.
The lower part of the gun head waste gas port 6 is communicated with a waste gun head collecting box 10, the lower part of the waste liquid discharge port 7 is communicated with a waste liquid collecting box 9, and the waste liquid collecting box 9 and the waste gun head collecting box 10 are in sliding connection with the bottom plate 13 and are supported by the bottom plate. The waste liquid collecting box 9 and the waste gun head collecting box 10 are the same collecting box, and a waste liquid collecting cavity and a waste gun head collecting gun head are formed in the same collecting box. Alternatively, the waste liquid collecting box 9 and the waste gun head collecting box 10 may be different collecting boxes, and the different collecting boxes are slidably connected with the bottom plate 13.
The last layer of the frame 1 is placed with the floor 13 of the whole plant. Wherein the gun head storage module 4 is placed on the board to play a supporting role. The bottom plate 13 is sufficiently strong here because of the pressure applied by the gun head. The collection boxes of the waste liquid and the waste gun heads are all placed on the bottom plate 13 and are positioned right below the corresponding discharge ports. The two parts can be pulled out of the device as a whole, thereby facilitating the discharge of waste and cleaning.
The waste gun head and the waste liquid collecting device are provided with a sliding rail structure, so that the waste can be conveniently drawn and recovered. The gun head collecting box is designed into a slope device, so that the gun head can be conveniently bounced up and put flat when falling down. The waste liquid box can be independently pulled and cleaned.
The automatic comprehensive treatment device for the tubular container can also comprise an ultraviolet function, a lighting function, a HEAP function, an emergency stop alarm function and the like. The user selects different functions according to the needs.
The control module comprises a computer hardware system, an electronic and electric control board and the actuating mechanism comprising a pipetting module, a centrifuge tube functional module and the like. The computer hardware system needs to install equipment operation software and is communicated with the electronic and electric control board through interfaces such as a serial port, a network port and the like. Under the instruction of equipment control software, the electronic and electric control board controls the pipetting module and the centrifuge tube functional module to realize various actions and specific functions. Through the cooperation of software and hardware, this device can realize getting the automation mechanized operation of the centrifuging tube common function such as flowing back, stirring mixing, rotatory mixing, blowing and sucking mixing, magnetic bead absorption, constant temperature heating. Meanwhile, according to different experimental requirements, the sequence of each action and function can be edited in the control software, so that different experimental flows are realized, and different experimental tasks are completed. Moreover, various parameters such as time, frequency, speed, position, temperature, combination state and the like of actions or functions can be adjusted; thereby achieving the optimal biological experiment result. Finally, the device also realizes the common auxiliary functions of automatic equipment such as ultraviolet sterilization, illumination, alarm, emergency stop and the like.
The automatic comprehensive treatment device for the tubular container not only comprises a centrifugal tube comprehensive treatment functional component, but also is additionally provided with a pipetting module, so that no experimenter is required in the whole process, and the occupied space is reduced.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (8)
1. The automatic comprehensive treatment device for the tubular container is characterized by comprising a rack, and a workbench surface, a pipetting module and a control module which are arranged on the rack;
the device comprises a workbench surface, a plurality of reagent placing boxes, a gun head storage module, a centrifuge tube functional module, a gun head waste port, a waste liquid discharge port and a sample collection box, wherein a plurality of reagent bottles are stored in the reagent placing boxes, a plurality of gun heads are stored in the gun head storage module, the centrifuge tube functional module is used for realizing rotation, magnetic attraction, heating and/or drying of a centrifuge tube, a collection pipe is arranged in the sample collection box, and a sample is stored in the collection pipe;
the pipetting module comprises one or more of a single-channel pipetting device or a multi-channel pipetting device, the pipetting module is positioned above the workbench surface, and the single-channel pipetting device or the multi-channel pipetting device is used for pipetting, draining liquid, pipetting among the modules or stirring and blowing-sucking a centrifuge tube;
the control module is electrically connected with the pipetting module and the centrifuge tube functional module and used for controlling the pipetting module and the centrifuge tube functional module to act.
2. The automated integrated processing system of claim 1, wherein the pipetting module further comprises an X-axis linear module, a Y-axis linear module, a first Z-axis linear module, and a second Z-axis linear module, wherein the single channel pipetting module is connected to the first Z-axis linear module, the multi-channel pipetting module is connected to the second Z-axis linear module, the first Z-axis linear module is connected to the Y-axis linear module, the second Z-axis linear module is connected to the X-axis linear module, and the Y-axis linear module is connected to the X-axis linear module.
3. The automated integrated tubular container handling apparatus of claim 1, further comprising an anti-drip device comprising an anti-drip plate and a first drive mechanism for driving movement of the anti-drip plate, the anti-drip plate being coupled to the first drive mechanism for driving the anti-drip plate to below the gun head.
4. The automated integrated processing system of claim 3, wherein the bottom of the reagent placement cassette is provided with a waterproof plate.
5. The automated comprehensive treatment device for tubular containers according to claim 1, wherein the gun head storage module comprises a gun head storage box, the gun head storage box comprises an upper clamping plate and a lower connecting plate, the upper clamping plate is fixed on the lower connecting plate, the lower connecting plate is connected with the bottom plate in a sliding manner and moves along the Y-axis direction of the bottom plate, and the gun head is clamped on the upper clamping plate.
6. The automated integrated processing unit of claim 5, wherein the gun head storage module further comprises a second drive mechanism for controlling the gun head storage box to move along the Y-axis direction of the bottom plate, the second drive mechanism is electrically connected with the control module, and the control module controls the second drive mechanism to act.
7. The automated integrated tubular container treatment device of claim 1, wherein the lower portion of the gun head waste gas port is in communication with a waste gun head collection box, the lower portion of the waste discharge port is in communication with a waste collection box, and both the waste collection box and the waste gun head collection box are slidably connected to and supported by the base plate.
8. The automated integrated tubular container treatment device of claim 7, wherein the waste collection cartridge and the waste gun head collection cartridge are the same cartridge, and the same cartridge has a waste collection cavity and a waste gun head collection cavity formed therein.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311044657.3A CN116870982A (en) | 2023-08-18 | 2023-08-18 | Automatic comprehensive treatment device for tubular container |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311044657.3A CN116870982A (en) | 2023-08-18 | 2023-08-18 | Automatic comprehensive treatment device for tubular container |
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| CN116870982A true CN116870982A (en) | 2023-10-13 |
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| CN202311044657.3A Pending CN116870982A (en) | 2023-08-18 | 2023-08-18 | Automatic comprehensive treatment device for tubular container |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117606975A (en) * | 2024-01-24 | 2024-02-27 | 中国科学院深圳先进技术研究院 | Automatic intelligent weighing system and method based on Internet control |
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- 2023-08-18 CN CN202311044657.3A patent/CN116870982A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117606975A (en) * | 2024-01-24 | 2024-02-27 | 中国科学院深圳先进技术研究院 | Automatic intelligent weighing system and method based on Internet control |
| CN117606975B (en) * | 2024-01-24 | 2024-06-18 | 中国科学院深圳先进技术研究院 | Automatic intelligent weighing system and method based on Internet control |
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