CN113578411B - Liquid transfer device - Google Patents
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- CN113578411B CN113578411B CN202111149950.7A CN202111149950A CN113578411B CN 113578411 B CN113578411 B CN 113578411B CN 202111149950 A CN202111149950 A CN 202111149950A CN 113578411 B CN113578411 B CN 113578411B
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- 239000007788 liquid Substances 0.000 title claims abstract description 79
- 238000012546 transfer Methods 0.000 title claims description 24
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 22
- 239000002699 waste material Substances 0.000 claims description 6
- 229910000831 Steel Inorganic materials 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 239000010959 steel Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 4
- 230000006978 adaptation Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
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Abstract
本发明属于生物实验设备技术领域，涉及一种移液装置，包括基座、设在基座上的台面组件以及位于台面组件上方的移液针组件，移液针组件包括微量吸液针和大容量吸液针，且大容量吸液针的吸液容量大于微量吸液针的吸液容量；还包括旋转阀，旋转阀的内部通道与大容量吸液针的大容量吸液通道连通时，大容量吸液通道与第一吸液动力源连通吸取大容量的溶液；旋转阀的内部通道与微量吸液针的微量吸液通道连通时，微量吸液通道与第二吸液动力源连通吸取微量的溶液；台面组件包括位于吸头放置区和加样区外侧的内转盘和外转盘，内转盘和外转盘具有放置不同尺寸试剂瓶的容纳孔。本发明具有同时处理微量和大容量样本液体、兼容不同试剂品的优点。
The invention belongs to the technical field of biological experimental equipment, and relates to a liquid pipetting device, comprising a base, a table top assembly disposed on the base, and a pipetting needle assembly located above the table top assembly. The volume suction needle, and the suction capacity of the large volume suction needle is greater than the suction capacity of the micro suction needle; it also includes a rotary valve, when the internal channel of the rotary valve is connected with the large volume suction channel of the large volume suction needle, The large-capacity suction channel is connected with the first suction power source to absorb a large-capacity solution; when the internal channel of the rotary valve is connected with the micro-aspiration channel of the micro-aspiration needle, the micro-aspiration channel is connected with the second suction power source for suction. A small amount of solution; the table assembly includes an inner turntable and an outer turntable located outside the tip placement area and the sample addition area, and the inner turntable and the outer turntable have accommodating holes for placing reagent bottles of different sizes. The invention has the advantages of simultaneously processing micro-volume and large-volume sample liquids and being compatible with different reagents.
Description
Technical Field
The invention belongs to the technical field of biological experiment equipment, relates to a liquid transfer device, and particularly relates to a modular multi-capacity liquid transfer device.
Background
At present, the experimental facilities that experimental fields such as biochemistry, medical treatment involved when carrying out the experiment are more and more, and all need carry out a large amount of liquid-transfering operations in most experiments, and the experimental facilities that need use this moment are liquid-transfering device. In general, a liquid transfer device is a liquid suction head that sucks liquid, which is required for transferring liquid, and transfers the sucked liquid to a predetermined position. For example, various liquid reagents and samples are mixed and the precise volume of each liquid is transferred to different analytical test devices for various preparations or assays.
The relatively common pipetting device is a pipetting gun, but needs manual multiple operation when carrying out pipetting operation, takes time and labor, and is poor to the precision of absorbing liquid because mainly operated by personnel, and in addition, the pipetting operation of current pipetting gun to the large capacity is difficult to realize. On the other hand, some automatic pipetting devices have a problem that the conventional pipetting devices are not universal in reagent table top, reagent bottles and sample application positions of different manufacturers and poor in compatibility.
Therefore, it is a problem to be solved how to improve the pipetting device to be able to process a small amount of sample liquid and a large amount of sample liquid at the same time, and to be compatible with different specifications of reagents from different manufacturers.
Disclosure of Invention
The liquid transfer device provided by the invention can be compatible with reagents of different manufacturers and different specifications while simultaneously processing trace and large-volume sample liquid.
The technical scheme of the invention comprises the following steps: a liquid transfer device comprises a base, a table board assembly arranged on the base and a liquid transfer needle assembly positioned above the table board assembly, wherein the liquid transfer needle assembly comprises a micro liquid suction needle and a large-capacity liquid suction needle, and the liquid suction capacity of the large-capacity liquid suction needle is larger than that of the micro liquid suction needle;
the pipetting needle assembly also comprises a rotary valve, and when an internal channel of the rotary valve is communicated with a high-capacity pipetting channel of the high-capacity pipetting needle, the high-capacity pipetting channel is communicated with the first pipetting power source to aspirate high-capacity solution; when the internal channel of the rotary valve is communicated with the micro imbibing channel of the micro imbibing needle, the micro imbibing channel is communicated with the second imbibing power source to absorb a trace amount of solution;
the table-board component comprises an inner rotary disc and an outer rotary disc which are positioned outside the suction head placing area and the sample adding area, and the inner rotary disc and the outer rotary disc are provided with accommodating holes for accommodating reagent bottles with different sizes.
The technical scheme of the invention also comprises: the high-capacity liquid suction needle comprises a needle tube I forming a high-capacity liquid suction channel and a hose communicated with the needle tube I, and the hose is connected with the first liquid suction power source.
The technical scheme of the invention also comprises: the micro imbibing needle comprises a needle tube II forming a micro imbibing channel, the needle tube II is connected with a second imbibing power source, and the volume of the micro imbibing channel is smaller than that of the large-capacity imbibing channel;
or the volume of the micro-suction channel is smaller than the sum of the volumes of the large-capacity suction channel and the hose.
The technical scheme of the invention also comprises: the first needle tube is a stainless steel needle;
and/or the needle tube II is a TIPS head steel needle.
The technical scheme of the invention also comprises: the liquid suction capacity of the micro liquid suction needle is less than 1000ul, and the liquid suction capacity of the large-capacity liquid suction needle is more than 1000 ul.
The technical scheme of the invention also comprises: the hole diameter of the containing hole of the outer rotary disk is larger than that of the containing hole of the inner rotary disk.
The technical scheme of the invention also comprises: the hole diameters of the accommodating holes of the outer rotating disc are consistent, and pipe sleeves with different diameters are placed in the accommodating holes of the outer rotating disc;
and/or the accommodating holes of the inner rotating disk are consistent in size, and pipe sleeves with different diameters are placed in the accommodating holes of the inner rotating disk.
The technical scheme of the invention also comprises: the outer rotating disc is provided with accommodating holes with different hole sizes, the inner rotating disc is provided with accommodating holes with different hole sizes, and the minimum hole size accommodating hole of the outer rotating disc is larger than the maximum hole size accommodating hole of the inner rotating disc.
The technical scheme of the invention also comprises: the suction head placing area comprises a disposable suction head placing area and a waste suction head placing area.
The technical scheme of the invention also comprises: the pipetting needle assembly is connected with a driving mechanism, and the driving mechanism comprises a Z-direction power source for driving the pipetting needle assembly to move up and down along a Z-direction moving track, a Y-direction power source for driving the pipetting needle assembly to move back and forth along a Y-direction moving track and an X-direction power source for driving the pipetting needle assembly to move left and right along an X-direction moving track.
The invention has the following beneficial effects: the micro liquid suction needle capable of sucking micro solution and the large-capacity liquid suction needle capable of sucking large-capacity solution are simultaneously designed on the liquid transfer needle assembly, and the micro liquid suction needle and the large-capacity liquid suction needle are alternatively communicated by using the rotary valve, so that two liquid transfer treatment modes of micro solution suction and large-capacity solution suction can be automatically switched, the liquid transfer treatment requirements of different solutions can be met, and the liquid transfer operation of different solutions can be simplified; meanwhile, the inner and outer rotating discs are designed on the table top assembly, and reagent bottles with different sizes are placed by the inner and outer rotating discs, so that the liquid transfer device is compatible with reagent products of different manufacturers and different specifications, and the adaptation compatibility of the liquid transfer device is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without inventive labor.
FIG. 1 is a schematic perspective view of a pipetting device in an embodiment.
FIG. 2 is a schematic front view of the pipetting device in the example.
FIG. 3 is a schematic side view of the pipetting device in an embodiment.
FIG. 4 is a schematic top view of the pipetting device in an embodiment.
Figure 5 is a schematic view of an example table top assembly.
FIG. 6 is a schematic view of a portion of the pipette assembly and drive mechanism.
FIG. 7 is a schematic view of a portion of a pipette needle assembly from a first perspective.
FIG. 8 is a schematic view of a portion of a pipetting needle assembly from a second perspective.
FIG. 9 is a schematic view showing the state of communication of the large-capacity pipette needle.
FIG. 10 is a schematic view showing the connection state of the micropipette.
Wherein: 1. A base 2, a table top component 21, an outer rotating disc 22, an inner rotating disc 23, a sucker placing area 231, a disposable sucker placing area 232, a waste sucker placing area 24, a sample adding area 3, a pipetting needle component 31, a micro pipetting needle 311, a micro pipetting channel 32, a large-capacity pipetting needle 321, a hose 322, a large-capacity pipetting channel 33, a rotary valve 41 and an X-direction power source 42 and an X-direction moving track 51 and a Y-direction power source 52 and a Y-direction moving track 61 and a Z-direction power source 62 and a Z-direction moving track.
Detailed Description
In order that those skilled in the art will better understand the disclosure, the invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
In this document, terms such as "upper, lower, left, right, inner, and outer" are established based on the positional relationship shown in the drawings, and the corresponding positional relationship may vary depending on the drawings, and therefore, the terms are not to be construed as an absolute limitation of the protection scope; moreover, relational terms such as "first" and "second," and the like, may be used solely to distinguish one element from another element having the same name, without necessarily requiring or implying any actual such relationship or order between such elements. In the embodiments of the present invention, "above", "below", and the like include the present numbers.
As shown in fig. 1 to 10, the embodiment of the present invention discloses a liquid transfer device, which is mainly used for liquid transfer operation in experiments of biochemistry, medical treatment, etc., and comprises a base 1, a table component 2 arranged on the base 1, and a liquid transfer needle component 3 positioned above the table component 2, wherein the liquid transfer needle component 3 comprises a liquid suction needle capable of realizing two different liquid transfer capacities, so as to meet the liquid transfer operation requirements of solutions with different capacities. Specifically, the micro pipette needle 31 and the large volume pipette needle 32 are provided, wherein the pipette capacity of the large volume pipette needle 32 is larger than that of the micro pipette needle 31, for example, the pipette capacity of the micro pipette needle 31 may be set to 1000ul or less, and the pipette capacity of the large volume pipette needle 32 may be set to 1000ul or more, and when a liquid dispensing of 1000ul or less needs to be processed, the micro pipette needle 31 mode of the pipette needle assembly 3 may be selected, and when a liquid dispensing of 1000ul or more needs to be processed, the large volume pipette needle 32 mode of the pipette needle assembly 3 may be selected.
In order to facilitate the free switching of two different volume pipetting operations, the pipetting needle assembly 3 is further designed with a rotary valve 33, when the internal channel of the rotary valve 33 is communicated with the large volume pipetting channel 322 of the large volume pipetting needle 32, the large volume pipetting channel 322 is communicated with the first pipetting power source to aspirate large volume of solution; when the internal channel of the rotary valve 33 communicates with the micropipette channel 311 of the micropipette 31, the micropipette channel 311 communicates with the second pipetting power source to aspirate a minute amount of solution.
Specifically, as shown in fig. 7 and 8, the rotary valve 33 is a spherical rotary valve having a through air passage, and as shown in fig. 9, when the air passage of the rotary valve 33 is connected to the air passage of the large-capacity pipette needle 32, i.e., the large-capacity pipette channel 322 of the large-capacity pipette needle 32, the air passage of the large-capacity pipette needle 32 is connected to the large-capacity pipette air pump, i.e., the first pipette power source, and the pipette liquid-separating operation is performed for 1000ul or more. As shown in FIG. 10, when the rotary valve 33 is rotated 90 degrees, the air passage of the rotary valve 33 is communicated with the air passage of the micropipette 31, i.e., the micropipette channel 311 of the micropipette 31, and the air passage of the micropipette 31 is connected with the micropipette pump, i.e., the second pipetting power source, to perform the pipetting operation of 1000. mu.l.
In this embodiment, as shown in fig. 4 and 5, the platform assembly 2 includes an inner rotary plate 22 and an outer rotary plate 21 located outside the tip placement region 23 and the sample addition region 24, and both the inner rotary plate 22 and the outer rotary plate 21 are provided with receiving holes, and the size of the receiving hole of the inner rotary plate 22 is designed to be different from the size of the receiving hole of the outer rotary plate 21, so as to be compatible with reagent bottles of different manufacturers and different specifications, thereby improving the compatibility of the pipetting device.
As shown in FIG. 1, the high volume pipette needle 32 includes a first needle cannula defining a high volume pipette channel 322 and a flexible tubing 321 in communication with the first needle cannula and the flexible tubing 321 is connected to a first source of suction power which may be located below the tabletop component 2. The micro pipetting needle 31 comprises a second needle tube forming a micro pipetting channel 311, and the second needle tube is connected with a second pipetting power source, specifically, the second pipetting power source can be arranged in the shell of the pipetting needle assembly 3.
Since the liquid suction capacity of the micropipette 31 is smaller than that of the large-capacity pipette needle 32, the volume of the micropipette passage 311 can be designed to be smaller than that of the large-capacity pipette passage 322. Alternatively, the volume of the micro pipette channel 311 is designed to be smaller than the sum of the volumes of the large volume pipette channel 322 and the flexible tube 321, that is, since both the large volume pipette channel 322 and the flexible tube 321 of the large volume pipette needle 32 can be used as the pipette volume, a large pipette throughput can be realized. Specifically, the first needle tube of the large-capacity pipette needle 32 may be a stainless steel needle, and the second needle tube of the micro pipette needle 31 may be a TIPS steel needle.
As shown in fig. 5, the diameter of the receiving hole of the outer rotary disk 21 is larger than that of the inner rotary disk 22, so that a reagent bottle having a larger diameter can be placed in the receiving hole of the outer rotary disk 21 and a reagent bottle having a smaller diameter can be placed in the receiving hole of the inner rotary disk 22. In order to be compatible with reagent bottles with different diameters, the diameter of the accommodating hole of the outer rotary disk 21 can be designed to be consistent, and sleeves with different diameters can be placed in the accommodating hole of the outer rotary disk 21 to match the reagent bottles with different diameters. Similarly, the receiving holes of the inner dial 22 are also sized to accommodate different diameter vials by placing different diameter sleeves within the receiving holes of the inner dial 22. Alternatively, the outer rotary disk 21 may be directly provided with receiving holes having different hole sizes, and the inner rotary disk 22 may be provided with receiving holes having different hole sizes, such that the smallest hole size of the outer rotary disk 21 is larger than the largest hole size of the inner rotary disk 22, thereby accommodating reagent bottles having different diameter sizes.
A tip placement region 23 and a sample addition region 24 are designed on the inner side of the inner rotary disk 22 of the table top component 2, wherein the tip placement region 23 comprises a disposable tip placement region 231 and a waste tip placement region 232. Taking fig. 5 as an example, the disposable tip placement area 231 of the tip placement area 23 is designed with 48 receiving locations for receiving 48 disposable tips simultaneously, and similarly, the waste tip placement area 232 is designed with 48 receiving locations for receiving 48 waste tips simultaneously. The sample application region 24 is designed with 32 accommodating positions for accommodating 4 rows of 8-cup PCR plates at the same time, but it should be understood that the number of the accommodating positions is merely an example, and different layouts can be made according to different sizes, and this embodiment is not limited thereto.
As shown in fig. 1 to 3 and 6, the pipetting needle unit 3 is connected to a drive mechanism, and specifically, the drive mechanism includes a Z-direction power source 61 for driving the pipetting needle unit 3 to move up and down along a Z-direction moving rail 62, a Y-direction power source 51 for driving the pipetting needle unit 3 to move forward and backward along a Y-direction moving rail 52, and an X-direction power source 41 for driving the pipetting needle unit 3 to move leftward and rightward along an X-direction moving rail 42. In operation, different types of reagent vials are placed on the outer and inner disks 21, 22 of the platform assembly 2, disposable tips are placed on the disposable tip placement region 231, and well PCR plates are placed on the sample addition region 24. According to the experimental setting, when small volume liquid separation is needed, the pipetting needle assembly 3 is moved to the position above the disposable tip placing area 231 by the driving of the X-direction power source 41, the Y-direction power source 51 and the Z-direction power source 61 in the driving mechanism, then the micro pipetting needle 31 loads the disposable tip, then the disposable tip is moved to the position above the outer rotary disk 21 or the inner rotary disk 22 where the reagent needs to be extracted to extract the reagent, and then the reagent is moved to the sample adding area 24 to be subpackaged, thus completing the small volume liquid transferring operation. Similarly, if a large-flux liquid transfer operation is required, the large-capacity liquid suction needle 32 is only required to be used for loading, liquid suction and split charging. In addition, in this embodiment, considering that the liquid transferring needle assembly 3 needs to change its XYZ three-way position continuously during the liquid transferring operation, if the three-way driving operation speed solely by the driving mechanism is slow, the table assembly 2 is designed to be a rotatable structure of the outward transferring tray 21 and the inward transferring tray 22, and in cooperation with the three-way driving of the driving mechanism, the reagent is rotated to a fixed point for extraction, so as to save time and improve efficiency.
In the case that the embodiments are not contradictory, at least some of the technical solutions in the embodiments may be recombined to form the essential technical solution of the present invention, and of course, the embodiments may also be cited or included in each other. Further, it should be noted that modifications and adaptations made by those skilled in the art when recombining technical means described in the respective embodiments will also fall within the scope of the present invention.
The technical principles of the present invention have been described above in connection with specific embodiments, but it should be noted that the above descriptions are only for the purpose of explaining the principles of the present invention, and should not be construed as specifically limiting the scope of the present invention in any way. Based on the explanations herein, those skilled in the art will appreciate that other embodiments of the present invention or equivalents thereof without inventive step, are also within the scope of the present invention.
Claims (10)
1. A liquid-transfering device, includes base (1), set up mesa subassembly (2) on base (1) and lie in liquid-transfering needle subassembly (3) of mesa subassembly (2) top, its characterized in that: the liquid transfer needle assembly (3) comprises a micro liquid suction needle (31) and a large-capacity liquid suction needle (32), and the liquid suction capacity of the large-capacity liquid suction needle (32) is larger than that of the micro liquid suction needle (31);
the pipetting needle assembly (3) further comprises a rotary valve (33), and when an internal channel of the rotary valve (33) is communicated with a high-capacity pipetting channel (322) of the high-capacity pipetting needle (32), the high-capacity pipetting channel (322) is communicated with a first pipetting power source to aspirate high-capacity solution; when the internal channel of the rotary valve (33) is communicated with the micro imbibing channel (311) of the micro imbibing needle (31), the micro imbibing channel (311) is communicated with a second imbibing power source to absorb micro solution;
the table-board component (2) comprises an inner rotary disc (22) and an outer rotary disc (21) which are positioned at the outer sides of a suction head placing area (23) and a sample adding area (24), and the inner rotary disc (22) and the outer rotary disc (21) are provided with accommodating holes for accommodating reagent bottles with different sizes;
the large-capacity liquid suction needle (32) comprises a needle tube I forming a large-capacity liquid suction channel (322) and a hose (321) communicated with the needle tube I, the micro liquid suction needle (31) comprises a needle tube II forming a micro liquid suction channel (311), and the lowest point of the large-capacity liquid suction needle (32) in the Z direction is lower than that of the micro liquid suction needle (31).
2. A pipetting device as recited in claim 1 wherein: the hose (321) is connected to a first source of suction power.
3. A pipetting device as recited in claim 2 wherein: the needle tube II is connected with a second liquid suction power source, and the volume of the micro liquid suction channel (311) is smaller than that of the large-capacity liquid suction channel (322);
alternatively, the volume of the micro suction channel (311) is smaller than the sum of the volumes of the large-volume suction channel (322) and the hose (321).
4. A pipette device according to claim 3, characterized in that: the first needle tube is a stainless steel needle;
and/or the needle tube II is a TIPS head steel needle.
5. A pipetting device as recited in claim 1 wherein: the liquid suction capacity of the micro liquid suction needle (31) is less than 1000ul, and the liquid suction capacity of the large-capacity liquid suction needle (32) is more than 1000 ul.
6. A pipetting device as recited in claim 1 wherein: the diameter of the accommodating hole of the outer rotary disk (21) is larger than that of the accommodating hole of the inner rotary disk (22).
7. A pipette device according to claim 6, characterized in that: the hole diameters of the accommodating holes of the outer turnplate (21) are consistent, and pipe sleeves with different diameters are placed in the accommodating holes of the outer turnplate (21);
and/or the accommodating holes of the inner rotary disk (22) are the same in size, and pipe sleeves with different diameters are placed in the accommodating holes of the inner rotary disk (22).
8. A pipette device according to claim 6, characterized in that: the outer rotating disc (21) is provided with accommodating holes with different hole diameters, the inner rotating disc (22) is provided with accommodating holes with different hole diameters, and the minimum hole diameter accommodating hole of the outer rotating disc (21) is larger than the maximum hole diameter accommodating hole of the inner rotating disc (22).
9. A pipetting device as recited in claim 1 wherein: the tip placement area (23) includes a disposable tip placement area (231) and a waste tip placement area (232).
10. A pipetting device as recited in claim 1 wherein: the pipetting needle assembly (3) is connected with a driving mechanism, and the driving mechanism comprises a Z-direction power source (61) for driving the pipetting needle assembly (3) to move up and down along a Z-direction moving track (62), a Y-direction power source (51) for driving the pipetting needle assembly (3) to move back and forth along a Y-direction moving track (52) and an X-direction power source (41) for driving the pipetting needle assembly (3) to move left and right along an X-direction moving track (42).
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| CN202111149950.7A CN113578411B (en) | 2021-09-29 | 2021-09-29 | Liquid transfer device |
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