CN116870128A - 一种用于治疗筋骨痛的组合药物及其制备方法 - Google Patents
一种用于治疗筋骨痛的组合药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于治疗筋骨痛的组合药物,以质量分数计,包括以下组分:精油组分:5~8份三七;3~8份伸筋草;2~4份独活;2.5~4份丹参;2~4份鸡血藤;2~4份生姜;2~4份细辛;混合粉组分:3~4份没药;2.5~4份香附;2~4份牛膝;2~4份桂枝;0.5~1份蝎子;2~4份丁香;0.5~0.8份血竭;1~2份丹参;1~2份红花,还公开了该组合药物制备方法,本发明适用于组合药物技术领域,提出了一种新的质量筋骨痛的组合药物及其制备方法,将部分中草药进行提取成精油进行复配,这样可以充分发挥皮肤渗透吸收的效果,能够促进药物的渗入,疗效快,标本兼治。
Description
技术领域
本发明属于组合药物技术领域,具体是一种用于治疗筋骨痛的组合药物及其制备方法。
背景技术
筋骨痛是一种临床常见病、多发病,近几年来,筋骨痛慢慢的在中青年人群中蔓延,主要为关节、肌肉、骨骼及关节周围的软组织等部位的疾病。常见筋骨痛的病种,如寒性关节痛、强制性脊柱炎、增生性关节炎、坐骨神经痛等。
现阶段,采用西医治疗筋骨痛时大多药效不持久,治标不治本,病情易复发,实践证明,西医进行筋骨痛的治疗方法均不理想且副作用大。现有发明CN105194569A一种用于治疗筋骨痛的药物组合物,该药物组合物包括联合使用的口服剂型和外敷剂型组成;所述口服剂型的原料组成为:独活,血竭,丁香,乳香,没药,延胡索,秦艽,桂枝,金刚刺,寻骨风,郁金,三七,黄芪,芡实;所述外敷剂型是由附着在胶片上的含有中药粉的药袋以及醋酸储备袋,所述中药粉的原料组成为:红花,透骨草,全蝎,松香,马钱子,鸡蛋壳。本发明通过口服及外敷不同的给药方式的组合,双管齐下,减轻人体肠胃负担,毒副作用小,外用剂型通过加入鸡蛋壳配合醋酸使用,能够促进药物的渗入。
然而,该产品的内服外治的功效是不符合受到不同程度的身体外部伤害的特症。口服是外用剂型通过加入鸡蛋壳配合醋酸使用,其实际这个只是通过醋酸和鸡蛋壳的反应产生醋酸钙,增加了钙但是不能促进药物的渗入吸收,钙只会沉积在胃表面。疗效一般,治疗不彻底。
发明内容
本发明的目的在于克服现有技术的缺陷,提供一种用于治疗筋骨痛的组合药物及其制备方法。
为实现上述目的,本发明采用了如下技术方案:
第一方面,一种用于治疗筋骨痛的组合药物,以质量分数计,包括以下组分:
精油组分:5~8份三七;3~8份伸筋草;2~4份独活;2.5~4份丹参;2~4份鸡血藤;2~4份生姜;2~4份细辛;
混合粉组分:3~4份没药;2.5~4份香附;2~4份牛膝;2~4份桂枝;0.5~1份蝎子;2~4份丁香;0.5~0.8份血竭;1~2份丹参;1~2份红花。
优选的,以质量分数计,包括以下组分:
精油组分:6份三七;6份伸筋草;3份独活;3份丹参;3份鸡血藤;3份生姜;3份细辛;
混合粉组分:3.5份没药;3份香附;3份牛膝;3份桂枝;0.8份蝎子;3份丁香;0.6份血竭;1.5份丹参;1.5份红花。
第二方面,一种用于治疗筋骨痛的组合药物制备方法,包括以下步骤:
S1中药精油的制备:将配方量三七、配方量伸筋草、配方量独活、配方量丹参、配方量鸡血藤、配方量生姜、配方量细辛放于容器内,加入6倍于中药材的大豆油,加热至180℃,边搅拌边加热2小时,关火静置24小时后,过滤形成中药精油;
S2混合粉的制备:将配方量没药、配方量香附、配方量牛膝、配方量桂枝、配方量蝎子、配方量丁香、配方量血竭、配方量丹参、配方量红花研磨,并经200目筛网筛选,得到混合粉。
优选的,使用时,取等量混合粉与中药精油进行复配。
综上所述,由于采用了上述技术方案,本发明的有益效果是:
本发明中,提出了一种新的质量筋骨痛的组合药物及其制备方法,将部分中草药进行提取成精油进行复配,这样可以充分发挥皮肤渗透吸收的效果,能够促进药物的渗入,疗效快,标本兼治。
具体实施方式
结合以下实施例,进一步说明本发明一种用于治疗筋骨痛的组合药物及其制备方法的具体实施方式。本发明一种用于治疗筋骨痛的组合药物及其制备方法不限于以下实施例的描述。
实施例1:
一种用于治疗筋骨痛的组合药物,以质量分数计,包括以下组分:
精油组分:5份三七;3份伸筋草;2份独活;2.5份丹参;2份鸡血藤;2份生姜;2份细辛;
混合粉组分:3份没药;2.5份香附;2份牛膝;2份桂枝;0.5份蝎子;2份丁香;0.5份血竭;1份丹参;1份红花。
实施例2:
一种用于治疗筋骨痛的组合药物,以质量分数计,包括以下组分:
精油组分:6份三七;6份伸筋草;3份独活;3份丹参;3份鸡血藤;3份生姜;3份细辛;
混合粉组分:3.5份没药;3份香附;3份牛膝;3份桂枝;0.8份蝎子;3份丁香;0.6份血竭;1.5份丹参;1.5份红花。
实施例3:
一种用于治疗筋骨痛的组合药物,以质量分数计,包括以下组分:
精油组分:8份三七;8份伸筋草;4份独活;4份丹参;4份鸡血藤;4份生姜;4份细辛;
混合粉组分:4份没药;4份香附;4份牛膝;4份桂枝;1份蝎子;4份丁香;0.8份血竭;2份丹参;2份红花。
实施例4:
一种用于治疗筋骨痛的组合药物制备方法,包括以下步骤:
S1中药精油的制备:将配方量三七、配方量伸筋草、配方量独活、配方量丹参、配方量鸡血藤、配方量生姜、配方量细辛放于容器内,加入6倍于中药材的大豆油,加热至180℃,边搅拌边加热2小时,关火静置24小时后,过滤形成中药精油;
S2混合粉的制备:将配方量没药、配方量香附、配方量牛膝、配方量桂枝、配方量蝎子、配方量丁香、配方量血竭、配方量丹参、配方量红花研磨,并经200目筛网筛选,得到混合粉。
进一步的,使用时,取等量混合粉与中药精油进行复配。
用法用量:取适量混合粉及等体积精油,搅拌混合后外敷至用药部位,并通过纱布包扎。每日1次,20天为一个疗程。
效果试验:
1.临床实验数据
临床病例:对730名已明确诊断为患有筋骨痛的患者,年龄为35-70周岁,男性380人,女性350人,在730名患者中,风湿性关节炎患者268名,软组织损伤患者212名,大骨节病患者250名。
中医证候:
治愈:症状全部消失,关节、肌肉疼痛消失,关节功能恢复正常;
显效:主要症状消除,关节、肌肉疼痛大部分消失或明显减轻,功能基本恢复正常;
有效:主要症状基本消失,功能有所恢复;无效:和治疗前相比,各方面均无进步,无明显好转。
治疗方法:外敷每日1次,20天为一个疗程。取适量混合粉及等体积精油,搅拌混合后外敷至用药部位,并通过纱布包扎。
治疗效果见表1。
表1:
组别 | 风湿性关节炎 | 软组织损伤 | 大骨节病 |
人数 | 268 | 212 | 250 |
治愈率 | 31.7%(85) | 54.2%(115) | 32.4%(81) |
显效率 | 32.4%(87) | 31.6%(67) | 31.6%(79) |
有效率 | 35.4%(95) | 13.2%(28) | 34.0%(85) |
无效率 | 0.003%(1) | 0.009%(2) | 2%(5) |
总有效率 | 99.997% | 99.991% | 98% |
应用本发明实施例制备的药物外敷对200名患者进行临床跟踪治疗,由于患病时间长短不一,因此根据实际患病时间使用2-3个疗程,坚持使用,疗程全部结束后进行统计,平均总有效率为98.51%;治疗过程中,无过敏等副反应的发生,跟踪调查发现,治愈的患者均无复发。
毒性试验:
试验方法:取SD大鼠80只,体重180~220g,雌雄各半,将大鼠平均分为3组,分别喂食本发明实施例1-4制备的中药精油和混合粉。药物喂食方法为:将本发明上述中药精油和混合粉的混合药物加水配成混悬液。每组大鼠每天三次灌胃药物混悬液,每天大鼠用药量为1.5g/Kg,大鼠禁食不禁水,
照此方法连续灌胃15天。
结果:在大鼠用药期间,大鼠均无中毒、死亡现象,各组大鼠活动、食欲正常。经解剖肾脏、肝脏、肾上腺皮质、生殖器均无明显变化。
结论:从上述结果可以看出,动物实验所用药物量远远高出成人临床用药的药量,但大鼠无死亡或器官变异状况发生,因此可以得出本发明药物在人体使用时亦无毒副作用。
典型病例:
张某,男,57岁,患肩关节周围炎,左肩不能上抬,外展内旋受限,疼痛向颈部及肘部放射,肩部怕冷,使用本发明实施例4制备的组合药物,外敷使用,取适量混合粉及等体积精油,搅拌混合后外敷至肩关节处,并通过纱布包扎,连续用药20天后疼痛消失,恢复劳动,达到临床治愈,用药前后血、尿、肝功能、肾功能检查均正常,无不良反应。停药1年后随访,未复发。
丁某,男,67岁,双膝关节疼痛数月,活动时关节内有响声,天气变凉疼痛加重,膝关节肿胀,活动受限,伸屈关节时有明显的摩擦感,诊断为风湿性关节炎使用本发明实施例4制备的组合药物,外敷使用,取适量混合粉及等体积精油,搅拌混合后外敷至膝关节处,并通过纱布包扎,用药10天后,疼痛及肿胀均减轻,20天后,疼痛消失,能够正常行走且恢复劳动能力,活动自如,临床治愈,用药前后血、尿、肝功能、肾功能检查均正常,无不良反应,至今未见复发。
以上内容是结合具体的优选实施方式对本发明所作的进一步详细说明,不能认定本发明的具体实施只局限于这些说明。对于本发明所属技术领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干简单推演或替换,都应当视为属于本发明的保护范围。
Claims (4)
1.一种用于治疗筋骨痛的组合药物,其特征在于,以质量分数计,包括以下组分:
精油组分:5~8份三七;3~8份伸筋草;2~4份独活;2.5~4份丹参;2~4份鸡血藤;2~4份生姜;2~4份细辛;
混合粉组分:3~4份没药;2.5~4份香附;2~4份牛膝;2~4份桂枝;0.5~1份蝎子;2~4份丁香;0.5~0.8份血竭;1~2份丹参;1~2份红花。
2.如权利要求1所述的一种用于治疗筋骨痛的组合药物,其特征在于,以质量分数计,包括以下组分:
精油组分:6份三七;6份伸筋草;3份独活;3份丹参;3份鸡血藤;3份生姜;3份细辛;
混合粉组分:3.5份没药;3份香附;3份牛膝;3份桂枝;0.8份蝎子;3份丁香;0.6份血竭;1.5份丹参;1.5份红花。
3.一种用于治疗筋骨痛的组合药物制备方法,其特征在于,包括以下步骤:
S1中药精油的制备:将配方量三七、配方量伸筋草、配方量独活、配方量丹参、配方量鸡血藤、配方量生姜、配方量细辛放于容器内,加入6倍于中药材的大豆油,加热至180℃,边搅拌边加热2小时,关火静置24小时后,过滤形成中药精油;
S2混合粉的制备:将配方量没药、配方量香附、配方量牛膝、配方量桂枝、配方量蝎子、配方量丁香、配方量血竭、配方量丹参、配方量红花研磨,并经200目筛网筛选,得到混合粉。
4.如权利要求1所述的一种用于治疗筋骨痛的组合药物制备方法,其特征在于:使用时,取等量混合粉与中药精油进行复配。
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