CN112618606A - 一种舒筋壮骨的中药组合物及其制备方法 - Google Patents
一种舒筋壮骨的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种舒筋壮骨的中药组合物,涉及中药技术领域。所述中药组合物包括以下中药组分:制马钱子、制川乌、川牛膝、红花、麻黄、细辛、鸡血藤、乳香、没药、雷公藤、青风藤、土鳖虫。本发明具有祛风除湿、温经散寒、活血化瘀、凉血消肿、消炎止痛、伸筋强筋接骨、补肝益肾作用,可治疗风湿、类风湿性关节炎,骨质增生。且本发明的中药组合物具有制作、服用方便,安全、无副作用的优点,同时,经过长期诊疗实践中检验证明本发明的中药组合物可解除患者的痛苦达到治病除根不再复发的效果和功能,具有修复关节的作用,治愈率高,可达百分之百。
Description
技术领域
本发明涉及中药技术领域,具体涉及一种舒筋壮骨的中药组合物及其制备方法。
背景技术
风湿、类风湿性关节炎、骨质增生病人群体越来越大,且难以治愈,被西医视为四大顽疾之一,病人一旦得病将终生承受病痛煎熬,不能正常工作和生活,身心受到极大的伤害,同时患者还要长期服用药物治疗,经济上造成很大的负担。目前,从各地区统计看,这两种病分布广、数量大,不管男女老少均有可能患此疾病。
多年来,医学界对风湿、类风湿性关节炎、骨质增生进行了深入的研究,但是目前很有效的治疗方法不多,西医治疗多数只能临时缓解,不能控制病情的发展,更难以根除,有的患者依靠激素缓解症状,只能解一时病痛,长期服用副作用也较大。现已公布一些中药内服治疗类风湿关节炎、骨质增生的方法,但其效果均不够明显,见效比较慢,长期服用副作用大、费用高、难以坚持。
发明内容
本发明提供的一种舒筋壮骨的中药组合物及其制备方法,旨在解决上述背景技术中存在的问题。
为了实现上述技术目的,本发明采用以下技术方案:
一种舒筋壮骨的中药组合物,,所述中药组合物包括以下中药组分:制马钱子、制川乌、川牛膝、红花、麻黄、细辛、鸡血藤、乳香、没药、雷公藤、青风藤、土鳖虫。
优选的,所述中药组分的重量配比为:制马钱子32-62份、制川乌32-62份、川牛膝43-83份、红花43-83份、麻黄58-98份、细辛30-60份、鸡血藤100-150份、乳香32-62份、没药32-62份、雷公藤100-150份、青风藤100-150份、土鳖虫158-218份。
进一步的,所述中药组分的重量配比为:制马钱子42-52份、制川乌42-52份、川牛膝53-73份、红花53-73份、麻黄68-88份、细辛40-50份、鸡血藤115-135份、乳香42-52份、没药42-52份、雷公藤115-135份、青风藤115-135份、土鳖虫178-198份。
更进一步的,所述中药组分的重量配比为:制马钱子47份、制川乌47份、川牛膝63份、红花63份、麻黄78份、细辛45份、鸡血藤125份、乳香47份、没药47份、雷公藤125份、青风藤125份、土鳖虫188份。
本发明的中药组合物中,是马钱科、马钱属植物。主要含有马钱子碱和番木鳖碱等多种生物碱。中医学上以种子炮制后入药,性寒,味苦,有通络散结,消肿止痛之效。
川乌正名为乌头(学名:Aconitum carmichaelii/Radix),别名:鹅儿花、铁花、五毒;被子植物门,毛茛科,乌头属。英文名Aconite Root,生于山地草坡或灌丛中。栽培于平地肥沃的砂质土壤,主要栽培于四川。有祛风除湿,温经止痛之功效。
川牛膝为苋科植物川牛膝Cyathula officinalis Kuan的干燥根。具有逐瘀通经,通利关节,利尿通淋。之功效。
红花(拉丁学名:Carthamus tinctorius L.),别名:红蓝花、刺红花,菊科、红花属植物,干燥的管状花,橙红色,花管狭细,先端5裂,裂片狭线形,花药黄色,联合成管,高出裂片之外,其中央有柱头露出。具特异香气,味微苦。以花片长、色鲜红、质柔软者为佳。有活血通经,散瘀止痛,有助于治经闭、痛经、恶露不行、胸痹心痛、瘀滞腹痛、胸胁刺痛、跌打损伤、疮疡肿痛疗效。
麻黄是指麻黄科草本类小灌木植物,亦是中药中的发散风寒药,一般在秋季采摘草麻黄、木贼麻黄和中麻黄干燥草质茎等晒干入药,。麻黄可以疏解肌表,促使患者发汗,还能化痰止咳,滋阴敛肺、运水祛湿。
细辛别名:华细辛、盆草细辛,拉丁文名:Asarum sieboldii Miq.是双子叶植物纲、马兜铃科、细辛属多年生草本。细辛具有祛风,散寒,行水,开窍的功效。
鸡血藤为豆科植物密花豆Spatholobus suberectus Dunn的干燥藤茎。具有活血补血,调经止痛,舒筋活络之功效。
乳香为橄榄科植物乳香树Boswellia carterii Birdw.及同属植物Boswelliabhaurdajiana Birdw.树皮渗出的树脂。分为索马里乳香和埃塞俄比亚乳香,每种乳香又分为乳香珠和原乳香。有活血行气止痛,消肿生肌的功效。
没药为橄榄科植物地丁树Commiphora myrrha Engl.或哈地丁树Commiphoramolmol Engl.的干燥树脂。具有散瘀定痛,消肿生肌之功效。
雷公藤为卫矛科植物雷公藤的根、叶及花。夏、秋采收。功能主治为:杀虫,消炎,解毒。
青风藤为清风藤科清风藤属植物清风藤Sabia japonica Maxim.的茎叶或根。具有祛风利湿,活血解毒之功效。
土鳖虫为鳖蠊科昆虫地鳖Eupolyph,aga sin,ensis Walker或冀地鳖Steleophaga Plancyi(Boleny)的雌虫干燥体。具有破血逐瘀,续筋接骨之功效。
其中,本发明公开的上述舒筋壮骨的中药组合物在治疗肢体关节疼痛中的用途。
优选的,所述肢体关节疼痛为由风湿、类风湿性关节炎,骨质增生引起的疼痛。
作为优选,本发明中,所述中药组合物为水丸剂。
本发明还进一步提供了一种制备舒筋壮骨的中药组合物的方法,包括如下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
与现有技术相比,本发明的有益效果为:本发明具有祛风除湿、温经散寒、活血化瘀、凉血消肿、消炎止痛、伸筋强筋接骨、补肝益肾作用,可治疗风湿、类风湿性关节炎,骨质增生。且本发明的中药组合物具有制作、服用方便,安全、无副作用的优点,同时,经过长期诊疗实践中检验证明本发明的中药组合物可解除患者的痛苦达到治病除根不再复发的效果和功能,具有修复关节的作用,治愈率高,可达百分之百。
具体实施方式
下面结合具体实施例对本发明作进一步详细描述,但不作为对本发明的限定。
实施例1
制马钱子32g、制川乌32g、川牛膝43g、红花43g、麻黄58g、细辛30g、鸡血藤100g、乳香32g、没药32g、雷公藤100g、青风藤100g、土鳖虫158g。
水丸剂的制备包括以下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
实施例2
制马钱子42g、制川乌42g、川牛膝53g、红花53g、麻黄68g、细辛40g、鸡血藤115g、乳香42g、没药42g、雷公藤115g、青风藤115g、土鳖虫178g。
水丸剂的制备包括以下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
实施例3
制马钱子47g、制川乌47g、川牛膝63g、红花63g、麻黄78g、细辛45g、鸡血藤125g、乳香47g、没药47g、雷公藤125g、青风藤125g、土鳖虫188g。
水丸剂的制备包括以下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
实施例4
制马钱子52g、制川乌52g、川牛膝73g、红花73g、麻黄88g、细辛50g、鸡血藤135g、乳香52g、没药52g、雷公藤135g、青风藤135g、土鳖虫198g。
水丸剂的制备包括以下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
实施例5
制马钱子62g、制川乌62g、川牛膝83g、红花83g、麻黄98g、细辛60g、鸡血藤150g、乳香62g、没药62g、雷公藤150g、青风藤150g、土鳖虫218g。
水丸剂的制备包括以下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
试验例1
检验:按《中华人民共和国药典》2015版中规定的丸剂项目下标准进行检验,上述实施1-5制备得到的丸剂符合药典要求。
对比例1
选取风湿、类风湿性关节炎,骨质增生患者150人,男女随机,平均分为两组。分别给予金乌骨通胶囊(贵州盛世龙方制药股份有限公司,按说明书一次3片,1日三次)、本发明中药组合物(实施例3,每日三次,每次10粒),持续治疗3个疗程(每30天为1疗程),不使用任何其他药物和针灸治疗方式。
症状评分标准:
1分:症状轻,不影响生活工作;
2分:症状较重,影响生活和工作,但可以忍受;
3分:症状严重,无法正常生活和工作,难以忍受。
可在1-3之间取小数进一步表示严重程度。
各组治疗前后评分(平均±s)
金乌骨通胶囊 | 本发明中药组合物 | |
治疗前 | 2.79±0.34 | 2.82±0.37 |
治疗后 | 1.53±0.35 | 1.28±0.29 |
从以上表中可知,本发明的中药组合物实际临床效果较为明显,且优于金乌骨通胶囊。
临床典型案例:
病例1:冯某某,男,48岁,阿鲁科尔沁旗人,患关节炎多年,每遇阴雨天疼痛加重,曾在医院就诊,化验结果类风湿因子高,诊断为类风湿关节炎,多处关节肿大变形,常年服用药物治疗,多为临时缓解、止痛,很快又会复发。2015年9月18日,来我院诊治,主诉:行走时膝关节疼痛难忍,站立时关节内部作响,生活不能自理,确诊为类风湿关节炎,使用本发明中药组合物,一个疗程症状缓解,巩固治疗二个疗程痊愈。
病例2:牟某某,女,57岁,阿鲁科尔沁旗人,2014年3月来院就诊,自诉患风湿关节炎多年,两膝关节增生变形,近两年病情更加严重,不能行走,不能正常工作,膝关节麻木酸胀加刺痛,影响正常生活,西医治疗多年未能治愈,使用本发明中药组合物,三个疗程痊愈。
病例3:何某某,女,46岁,阿鲁科尔沁旗人,患类风湿关节炎多年,阴雨寒冷天加重,左手拇指、食指关节肿大变形,长期服用药物缓解疼痛。2014年10月2日来我院诊治,主诉:手关节疼痛,握持困难,生活不能自理,确诊为类风湿关节炎,使用本发明中药组合物,一个疗程疼痛减轻,巩固治疗二个疗程痊愈。
以上显示和描述了本发明的基本原理和主要特征及本发明的优点。应当指出,对于本技术领域的普通技术人员来说,在不脱离本发明基本原理的前提下,还可以做出若干改进和润饰,这些改进和润饰也视为本发明的保护范围。
Claims (8)
1.一种舒筋壮骨的中药组合物,其特征在于,所述中药组合物包括以下中药组分:制马钱子、制川乌、川牛膝、红花、麻黄、细辛、鸡血藤、乳香、没药、雷公藤、青风藤、土鳖虫。
2.根据权利要求1所述的舒筋壮骨的中药组合物,其特征在于,所述中药组分的重量配比为:制马钱子32-62份、制川乌32-62份、川牛膝43-83份、红花43-83份、麻黄58-98份、细辛30-60份、鸡血藤100-150份、乳香32-62份、没药32-62份、雷公藤100-150份、青风藤100-150份、土鳖虫158-218份。
3.根据权利要求2所述的舒筋壮骨的中药组合物,其特征在于,所述中药组分的重量配比为:制马钱子42-52份、制川乌42-52份、川牛膝53-73份、红花53-73份、麻黄68-88份、细辛40-50份、鸡血藤115-135份、乳香42-52份、没药42-52份、雷公藤115-135份、青风藤115-135份、土鳖虫178-198份。
4.根据权利要求3所述的舒筋壮骨的中药组合物,其特征在于,所述中药组分的重量配比为:制马钱子47份、制川乌47份、川牛膝63份、红花63份、麻黄78份、细辛45份、鸡血藤125份、乳香47份、没药47份、雷公藤125份、青风藤125份、土鳖虫188份。
5.根据权利要4所述的舒筋壮骨的中药组合物在治疗肢体关节疼痛中的用途。
6.根据权利要5所述的舒筋壮骨的中药组合物,其特征在于:所述肢体关节疼痛为由风湿、类风湿性关节炎,骨质增生引起的疼痛。
7.根据权利要求1-6任一项所述的舒筋壮骨的中药组合物,其特征在于:所述中药组合物为水丸剂。
8.一种制备如权利要求7所述的舒筋壮骨的中药组合物的方法,其特征在于,包括如下步骤:
S1称重:将各中药组分按照重量比称重;
S2粉碎:取称量后的中药组分,分别进行粉碎,过100目筛,得到各原料药粉;
S3混合:将各原料药粉混合均匀;
S4成条制丸:向S3的原料药粉中,按1:1.2~1.5的比例加入纯化水,充分搅拌,手工和为一团;将药团均匀切成块状大小,搓条后再分切搓丸,得到素丸;
S5成丸:将S4中搓得的素丸进行抛光、干燥、晾丸,即得成品,每10粒重1.0克。
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