CN116870074B - Chinese medicinal liniment for preventing hair loss and promoting hair growth, and its preparation method - Google Patents
Chinese medicinal liniment for preventing hair loss and promoting hair growth, and its preparation method Download PDFInfo
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- CN116870074B CN116870074B CN202311017001.2A CN202311017001A CN116870074B CN 116870074 B CN116870074 B CN 116870074B CN 202311017001 A CN202311017001 A CN 202311017001A CN 116870074 B CN116870074 B CN 116870074B
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention provides a traditional Chinese medicine liniment for preventing hair loss and promoting hair growth and a preparation method thereof, and relates to the technical field of traditional Chinese medicine liniment processing. The Chinese medicinal liniment comprises Chinese medicinal effective components, an oil phase, an emulsifying agent, an auxiliary emulsifying agent and distilled water, wherein the Chinese medicinal effective components comprise extracts mixed by folium Berberidis Amurensis, fructus Xanthii, radix astragali and yellow tea, and fermented extracts mixed by Polygoni Multiflori radix, poria and herba et Gemma Agrimoniae. The invention overcomes the defects of the prior art, effectively improves the effects of preventing hair loss and growing hair through the compound extraction of a plurality of traditional Chinese medicines, reduces the medicinal toxicity, improves the use safety of the liniment, and further improves the use feeling.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine liniment processing, in particular to an anti-hair loss and hair growth traditional Chinese medicine liniment and a preparation method thereof.
Background
The human hair has certain defending function and body temperature keeping function, and the hair also has good modification function, so that the hair can be better shown to a certain extent, and the appearance confidence of people can be improved.
Alopecia is a common and frequently-occurring skin disease with excessive hair loss and sparse hair as main clinical manifestations, and androgenic alopecia and alopecia areata are more common. Epidemiological investigation shows that the global alopecia population accounts for 2%, the alopecia rates of men and women in China are 21.3% and 6.0% respectively, wherein the alopecia rate of men before 30 years is up to 84%, and the data is also rising year by year. Modern medicine considers that various pathogenic factors such as heredity, autoimmunity, psychology, endocrine, cytokines and microelements lead to hair follicle micromation through abnormal regulation of hair growth cycle, thereby inducing alopecia
In addition to the above factors, long-term mental stress, eating disorders, psychological imbalance, and pathogenic bacterial infections (e.g., malassezia furfur, propionibacterium acnes, etc.) are important factors that induce or exacerbate the disease. The treatment scheme aiming at seborrheic alopecia comprises Western medicine and traditional Chinese medicine therapy, western medicine is mainly a single target point, for example, the oral medicine finasteride and the external minoxidil tincture mainly have side effects of feminization and great skin irritation of a user through antagonizing androgens; the traditional Chinese medicine treatment mainly uses the traditional Chinese medicine theory to carry out Chinese herbal medicine treatment, mainly uses multiple targets, is mainly based on the principle of combining the differentiation of the alopecia with dialectics of the traditional Chinese medicine treatment, is prepared by screening natural plant medicines for nourishing blood, soothing the nerves, soothing the liver, relieving depression and tonifying qi and promoting hair growth, and patent number CN201310319642.3 discloses a traditional Chinese medicine for treating alopecia, and a good anti-drop effect is achieved by adopting the assistance of multiple medicinal materials, but the medicine is an oral medicine, has heavy burden on kidneys after long-term administration, has poor oral traditional Chinese medicine treatment experience in the whole treatment process, and has poor overall convenience.
In addition, the general Chinese herbal medicine compound or related preparation is prepared into tincture aiming at most of seborrheic alopecia, and has great irritation to scalp as a whole and seriously affects the using sense.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the traditional Chinese medicine liniment for preventing and growing hair and the preparation method thereof, which effectively improve the efficacy of preventing and growing hair by compounding and extracting a plurality of traditional Chinese medicines, reduce the medicinal toxicity, improve the use safety of the liniment and further improve the use feeling.
In order to achieve the above object, the technical scheme of the present invention is realized by the following technical scheme:
The traditional Chinese medicine liniment for preventing and growing hair comprises the following raw materials in parts by weight: 0.8-1.2 parts of traditional Chinese medicine active ingredient, 4-6 parts of oil phase, 8-10 parts of emulsifying agent, 1-2 parts of auxiliary emulsifying agent and 20-25 parts of distilled water; the Chinese medicinal active ingredients comprise mixed extracts of folium Berberidis Amurensis, fructus Xanthii, radix astragali and yellow tea, and mixed and fermented extracts of Polygoni Multiflori radix, poria and herba et Gemma Agrimoniae at a mass ratio of 1:1.
Preferably, the oil phase is octyl dodecanol, the emulsifier is polyoxyethylene castor oil, and the auxiliary emulsifier is glycol.
Preferably, the preparation method of the mixed extract in the traditional Chinese medicine active ingredients comprises the following steps:
s1-1, mixing the side primary leaves, the cocklebur fruit, the astragalus mongholicus and the yellow tea according to the mass ratio of 4:2:3:1, adding deionized water for one time, and grinding into slurry to obtain first slurry for later use;
S1-2, placing the first slurry in a refrigerator, freezing for 24 hours at the temperature of 15 ℃ below zero to 18 ℃ below zero, taking out, adding warm water with the volume being 3 times, and carrying out water bath heat preservation and thawing to obtain a mixture;
S1-3, performing intermittent ultrasonic vibration treatment on the mixture, centrifuging to obtain supernatant, continuously adding 3 times of deionized water into the precipitate, performing intermittent ultrasonic vibration treatment, centrifuging, combining the supernatant, concentrating the supernatant in vacuum, and lyophilizing to obtain the mixed extract.
Preferably, the temperature of the warm water added in the step S1-2 is 60-80 ℃.
Preferably, the intermittent ultrasonic vibration treatment in the step S1-3 is carried out by extracting for 3-5min at 25KHz ultrasonic frequency, standing for 5-10min, extracting for 3-5min at 25KHz ultrasonic frequency again, repeating ultrasonic and standing treatment for 3-5 times, and controlling the temperature at 40-60 ℃ in the whole intermittent ultrasonic vibration treatment process.
Preferably, the preparation method of the fermentation extract comprises the following steps:
s2-1, mixing polygonum multiflorum, poria cocos and hairyvein agrimony according to the mass ratio of 2:1:4, adding deionized water with one volume, and grinding into slurry to obtain second slurry for later use;
s2-2, inoculating bifidobacteria and lactobacillus acidophilus into the second slurry, fermenting for 8-10d at the temperature of 43+/-2 ℃, and then taking out to obtain a fermentation material for later use;
S2-3, adding clear water with the volume being 2 times that of the fermentation material, heating to 90-100 ℃, boiling for 2 hours, filtering, continuously adding clear water into filter residues, boiling, filtering, and combining the two filtrates to obtain an extracting solution for later use;
S2-4, concentrating the extracting solution in vacuum, and freeze-drying at low temperature to obtain a fermentation extract.
Preferably, the inoculating mode of the bifidobacterium and the lactobacillus acidophilus in the step (2) is as follows: and respectively mixing the bifidobacteria, the lactobacillus acidophilus and the clear water according to the mass ratio of 1:100, and then activating for 12 hours at the temperature of 43+/-2 ℃ to obtain a bifidobacteria activating solution and a lactobacillus acidophilus activating solution, and respectively adding 5% of the bifidobacteria activating solution and 3% of the lactobacillus acidophilus activating solution into the second slurry according to the volume ratio.
A preparation method of the traditional Chinese medicine liniment for preventing alopecia and promoting hair growth comprises the following steps:
(1) Mixing the effective components of the traditional Chinese medicine in the oil phase, and fully and uniformly stirring to obtain a first mixed phase for standby;
(2) Adding an emulsifying agent and an auxiliary emulsifying agent into the first mixed phase, heating in a water bath, and uniformly stirring to obtain a second mixed phase for later use;
(3) Slowly dripping distilled water into the second mixed phase until clear and transparent microemulsion is formed, and then cooling and standing in a refrigerator for 12-24 hours to obtain primary mixed solution for later use;
(4) Adding the rest distilled water into the primary mixed solution, and stirring to obtain the hair growth promoting Chinese medicinal liniment.
Preferably, the temperature of the water bath in the step (2) for heating and stirring uniformly is 40+/-2 ℃, the stirring rotating speed is 120r/min, and the stirring time is 30-50min.
Preferably, the cooling temperature in the step (3) is 2-4 ℃.
The invention provides a traditional Chinese medicine liniment for preventing hair loss and promoting hair growth and a preparation method thereof, and compared with the prior art, the traditional Chinese medicine liniment has the advantages that:
(1) According to the invention, the folium polygoni multiflori, the fructus xanthii, the radix astragali and the large yellow tea are ground and frozen to be combined with intermittent ultrasonic extraction, so that effective substances are obtained, seborrheic alopecia can be effectively inhibited, meanwhile, the active ingredients are extracted after the traditional Chinese medicinal materials with stronger stimulation such as the polygonum multiflorum, the poria cocos and the hairyvein agrimony are fermented, the toxicity is effectively reduced, the alopecia treatment effect is ensured, the treatment effect of the liniment is integrally improved, and the treatment safety is ensured.
(2) According to the invention, the oil phase, the emulsifier and the auxiliary emulsifier are mixed and dissolved to obtain the traditional Chinese medicine active ingredients, and finally the product is prepared into the stable microemulsion, so that the irritation to the scalp can be relieved while the use effect of the liniment is effectively ensured, the use comfort is further improved, the medicine can act for a long time after being smeared, and the overall treatment effect is improved.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described in the following in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1:
1. preparation of traditional Chinese medicine mixed extract A:
(1) Mixing the side primary leaves, the cocklebur fruits, the astragalus mongholicus and the large yellow tea according to the mass ratio of 4:2:3:1, adding one time of deionized water, and grinding into slurry to obtain first slurry for later use;
(2) The first sizing agent is placed in a refrigerator to be frozen for 24 hours at the temperature of 15 ℃ below zero to 18 ℃ below zero, then is taken out, and is added with 70 ℃ warm water with 3 times of volume and is subjected to water bath heat preservation for thawing, thus obtaining a mixture;
(3) And (3) carrying out intermittent ultrasonic vibration treatment on the mixture, centrifuging to obtain a supernatant, continuously adding 3 volumes of deionized water into the precipitate, extracting for 4min at an ultrasonic frequency of 25KHz, standing for 8min, extracting for 4min at an ultrasonic frequency of 25KHz again, repeating ultrasonic and standing treatment for 4 times, controlling the temperature at 50 ℃ in the whole intermittent ultrasonic vibration treatment process, centrifuging to obtain the supernatant, continuously adding 3 volumes of deionized water into the precipitate, centrifuging after repeating the intermittent ultrasonic vibration treatment, combining the two supernatants, concentrating the supernatant in vacuum, and freeze-drying to obtain the mixed extract A.
2. Preparing a traditional Chinese medicine mixed extract B:
(1) Mixing folium Plastrum Testudinis, fructus Xanthii, radix astragali, radix et rhizoma Rhei tea, polygoni Multiflori radix, poria, and herba et Gemma Agrimoniae at a mass ratio of 4:2:3:1:2:1:4, adding one time deionized water, and grinding to obtain first slurry;
(2) The first sizing agent is placed in a refrigerator to be frozen for 24 hours at the temperature of 15 ℃ below zero to 18 ℃ below zero, then is taken out, and is added with 70 ℃ warm water with 3 times of volume and is subjected to water bath heat preservation for thawing, thus obtaining a mixture;
(3) And (3) carrying out intermittent ultrasonic vibration treatment on the mixture, centrifuging to obtain a supernatant, continuously adding 3 volumes of deionized water into the precipitate, extracting for 4min at an ultrasonic frequency of 25KHz, standing for 8min, extracting for 4min at an ultrasonic frequency of 25KHz again, repeating ultrasonic and standing treatment for 4 times, controlling the temperature at 50 ℃ in the whole intermittent ultrasonic vibration treatment process, centrifuging to obtain the supernatant, continuously adding 3 volumes of deionized water into the precipitate, centrifuging after repeating the intermittent ultrasonic vibration treatment, combining the two supernatants, concentrating the supernatant in vacuum, and freeze-drying to obtain the mixed extract B.
3. Preparation of traditional Chinese medicine fermentation extract A:
(1) Mixing polygonum multiflorum, poria cocos and hairyvein agrimony according to the mass ratio of 2:1:4, adding deionized water with one volume, and grinding into slurry to obtain second slurry for later use;
(2) Mixing bifidobacteria, lactobacillus acidophilus and clear water according to the mass ratio of 1:100, activating for 12 hours at the temperature of 43+/-2 ℃ to obtain a bifidobacteria activating solution and a lactobacillus acidophilus activating solution, adding 5% of the bifidobacteria activating solution and 3% of the lactobacillus acidophilus activating solution into the second slurry according to the volume ratio, fermenting for 10 days at the temperature of 43+/-2 ℃ and taking out to obtain a fermented material for later use;
(3) Adding clear water with volume 2 times of that of the fermented material, heating to 95 ℃, boiling for 2 hours, filtering, continuously adding clear water into filter residues, boiling, filtering, and combining the two filtrates to obtain an extracting solution for later use;
(4) Concentrating the extractive solution under vacuum, and lyophilizing to obtain fermented extract A.
4. Preparing a traditional Chinese medicine fermentation extract B:
(1) Mixing the side primary leaves, the cocklebur fruits, the astragalus roots, the yellow tea, the polygonum multiflorum, the poria cocos, the hairyvein agrimony according to the mass ratio of 4:2:3:1:2:1:4, adding deionized water with one volume, and grinding into slurry to obtain a second slurry for standby;
(2) Mixing bifidobacteria, lactobacillus acidophilus and clear water according to the mass ratio of 1:100, activating for 12 hours at the temperature of 43+/-2 ℃ to obtain a bifidobacteria activating solution and a lactobacillus acidophilus activating solution, adding 5% of the bifidobacteria activating solution and 3% of the lactobacillus acidophilus activating solution into the second slurry according to the volume ratio, fermenting for 10 days at the temperature of 43+/-2 ℃ and taking out to obtain a fermented material for later use;
(3) Adding clear water with volume 2 times of that of the fermented material, heating to 95 ℃, boiling for 2 hours, filtering, continuously adding clear water into filter residues, boiling, filtering, and combining the two filtrates to obtain an extracting solution for later use;
(4) Concentrating the extractive solution under vacuum, and lyophilizing to obtain fermented extract B.
Example 2:
the preparation method of the traditional Chinese medicine liniment for preventing alopecia and promoting hair growth comprises the following steps:
(1) Mixing 1g of traditional Chinese medicine active ingredient into 5g of octyl dodecanol, and fully and uniformly stirring to obtain a first mixed phase for standby;
(2) Adding 9g of polyoxyethylene castor oil and 1.5g of ethylene glycol into the first mixed phase, heating in a water bath at the temperature of 40+/-2 ℃, and stirring at the stirring speed of 120r/min for 40min to obtain a second mixed phase for later use;
(3) Preparing 23g of distilled water, slowly dripping into the second mixed phase until clear and transparent microemulsion is formed, stopping dripping, and refrigerating and standing in a refrigerator at the temperature of 3 ℃ for 18 hours to obtain a primary mixed solution for later use;
(4) Adding the rest distilled water into the primary mixed solution, and stirring to obtain the hair growth promoting Chinese medicinal liniment.
Each group of liniment was prepared according to the preparation method described above, according to the selection of the active ingredients of the traditional Chinese medicines in table 1 below:
TABLE 1
| Group of | Formula of effective components of traditional Chinese medicine |
| Experiment group 1 | Mixing the mixed extract A and the fermented extract A at a mass ratio of 1:1 |
| Experiment group 2 | Mixed extract A |
| Experiment group 3 | Mixed extract B |
| Experiment group 4 | Fermentation extract A |
| Experiment group 5 | Fermentation extract B |
Example 3:
1. a control group was set according to the preparation method of example 2, wherein the control group was prepared as follows:
Control group 1: mixing the mixed extract A and the fermented extract A in a mass ratio of 1:1 to prepare effective components of the traditional Chinese medicine, adding 38.5 distilled water into 1g of the effective components of the traditional Chinese medicine, and uniformly mixing and stirring to obtain a liniment;
Control group 2: adding 9g of polyoxyethylene castor oil and 1.5g of ethylene glycol into 5g of octyl dodecanol, heating in a water bath at the temperature of 40+/-2 ℃, stirring for 40min at the stirring speed of 120r/min, uniformly mixing, then preparing 23g of distilled water, slowly dropwise adding the distilled water until clear and transparent microemulsion is formed, stopping dropwise adding, cooling in a refrigerator at the temperature of 3 ℃ for 18h, and mixing the rest distilled water to obtain the liniment;
Control group 3: preparing physiological saline as liniment;
2. Skin irritation experiments:
80 guinea pigs with the weight of 300-500g are selected, and the average weight of the guinea pigs is divided into 8 groups of 10, and the male and female animals are half:
Feeding conditions: the complete nutrition pellet feed is fed and fed in separate cages in an air conditioning room, the room temperature is 21+2 ℃, the relative humidity is 40-70%, the illumination is carried out for 12 hours every day, tap water is freely drunk, and the feed is adaptively fed for three days before administration.
The experimental process comprises the following steps: the hair on the compound side of each group of guinea pigs is removed, then the compound side of each group of guinea pigs is wiped clean by normal saline, then each group of guinea pigs is wiped by the wipes of the experimental groups 1-5 and the control groups 1-2, the feed is normally fed, and the wiping mode is that the wiping is performed once every 8 hours, the wiping lasts for 7 days, and the skin change condition of the guinea pigs corresponding to each group during wiping for 3 days and 7 days is observed, as shown in the following table 2:
TABLE 2
As can be seen from the above table, after long-term wiping with physiological saline (control group 3) (7 d), guinea pig skin was prone to reddening, which is a slight inflammation caused by skin friction during long-term wiping, but the time resolved, whereas in control group 2: the components such as the oil phase, the emulsifier and the like can cause skin irritation to a certain extent, skin erythema is easy to cause under long-time wiping, and the skin in the groups (experiment group 1 and experiment group 2) added with the mixed extract A is normal, so that the substances in the mixed extract A have a certain sedative and anti-inflammatory effect, can protect the skin to a certain extent, and the skin irritation is strong when the polygonum multiflorum, the poria cocos and the hairyvein agrimony (experiment group 3) which are not fermented are added, so that the skin of the dolphin can cause strong anaphylactic reaction.
2. The control effect of the liniment prepared in the experimental group 1 on alopecia is detected:
Patients 90 (of which men 60 and women 30) with a hair loss rating of 2-3 were selected according to Hamilton-Norwood typing, randomly divided into 3 groups of 30 (men 20 and women 10), and each group of patients was designated treatment group 1, treatment group 2 and treatment group 3, and the treatment-related drugs were discontinued 2 weeks before each group of patients was tested, and there were no other diseases related to hair loss recently;
the treatment mode is that the scalp is smeared with the medicament in the morning and evening, 6-5ml of the medicament is used each time, and the medicaments used by the treatment groups are shown in the following table 3:
TABLE 3 Table 3
The average hair loss of each treatment group was measured before treatment, and then each treatment group was measured every two weeks during treatment, and the treatment was continued for 12 weeks, and the treatment effects were recorded as shown in table 4 below, wherein the pattern of hair loss measurement was as follows: taking shampoo, carefully kneading scalp, washing, collecting shampoo by adopting a container in the whole hair washing process, filtering, collecting fallen hair, and recording the hair loss reduction percentage as the hair loss improvement condition, wherein the specific calculation is as follows:
Percent reduction of hair loss = (number of pre-treatment hair loss-number of post-treatment hair loss)/number of pre-treatment hair loss x 100%
TABLE 4 Table 4
As can be seen from the above table, the therapeutic group 1 has more stable and durable anti-hair loss effect than the therapeutic group 2, although the early therapeutic effect of the therapeutic group 2 is better, the durability and final therapeutic effect are worse than the therapeutic group 1, and the therapeutic group 1 has a faster effect in the whole therapeutic process and a better therapeutic effect at 12 weeks, and the therapeutic effect of the therapeutic group 1 has a faster effect than the minoxidil therapeutic effect of the therapeutic group 3, and the therapeutic effect of the therapeutic group 1 has a smaller difference at 12 weeks, i.e., the therapeutic group 1 has a remarkable effect of treating hair loss.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
The above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (5)
1. The traditional Chinese medicine liniment for preventing hair loss and promoting hair growth is characterized by comprising the following raw materials in parts by weight: 0.8-1.2 parts of traditional Chinese medicine active ingredient, 4-6 parts of oil phase, 8-10 parts of emulsifying agent, 1-2 parts of auxiliary emulsifying agent and 20-25 parts of distilled water;
the active ingredients of the traditional Chinese medicine are mixed extracts of the side primary leaves, the cocklebur fruits, the astragalus and the yellow tea, and mixed fermentation extracts of the polygonum multiflorum, the poria cocos and the hairyvein agrimony according to the mass ratio of 1:1;
the oil phase is octyl dodecanol, the emulsifying agent is polyoxyethylene castor oil, and the auxiliary emulsifying agent is glycol;
the preparation method of the mixed extract in the traditional Chinese medicine active ingredients comprises the following steps:
s1-1, mixing the side primary leaves, the cocklebur fruit, the astragalus mongholicus and the yellow tea according to the mass ratio of 4:2:3:1, adding deionized water for one time, and grinding into slurry to obtain first slurry for later use;
S1-2, placing the first slurry in a refrigerator, freezing for 24 hours at the temperature of 15 ℃ below zero to 18 ℃ below zero, taking out, adding warm water with the volume being 3 times, and carrying out water bath heat preservation and thawing to obtain a mixture;
S1-3, performing intermittent ultrasonic vibration treatment on the mixture, centrifuging to obtain a supernatant, continuously adding deionized water with 3 times of volume into the precipitate, performing intermittent ultrasonic vibration treatment, centrifuging, combining the supernatant twice, concentrating the supernatant in vacuum, and freeze-drying to obtain a mixed extract, wherein the intermittent ultrasonic vibration treatment is performed by extracting at 25KHz for 3-5min, standing for 5-10min, extracting at 25KHz for 3-5min again, repeating ultrasonic and standing treatment for 3-5 times, and controlling the temperature at 40-60 ℃ in the whole intermittent ultrasonic vibration treatment process;
the preparation method of the fermentation extract comprises the following steps:
s2-1, mixing polygonum multiflorum, poria cocos and hairyvein agrimony according to the mass ratio of 2:1:4, adding deionized water with one volume, and grinding into slurry to obtain second slurry for later use;
S2-2, inoculating bifidobacteria and lactobacillus acidophilus into the second slurry, fermenting for 8-10d at the temperature of 43+/-2 ℃, and then taking out to obtain a fermented material for later use, wherein the inoculating mode of the bifidobacteria and the lactobacillus acidophilus is as follows: respectively mixing bifidobacteria, lactobacillus acidophilus and clear water according to the mass ratio of 1:100, and activating for 12 hours at the temperature of 43+/-2 ℃ to obtain a bifidobacteria activating solution and a lactobacillus acidophilus activating solution, and respectively adding 5% of the bifidobacteria activating solution and 3% of the lactobacillus acidophilus activating solution into the second slurry according to the volume ratio;
S2-3, adding clear water with the volume being 2 times that of the fermentation material, heating to 90-100 ℃, boiling for 2 hours, filtering, continuously adding clear water into filter residues, boiling, filtering, and combining the two filtrates to obtain an extracting solution for later use;
S2-4, concentrating the extracting solution in vacuum, and freeze-drying at low temperature to obtain a fermentation extract.
2. The hair-loss preventing and hair-growing traditional Chinese medicine liniment according to claim 1, which is characterized in that: the temperature of the warm water added in the step S1-2 is 60-80 ℃.
3. A method for preparing the alopecia preventing and hair growth promoting traditional Chinese medicine liniment according to claim 1, which is characterized in that: the preparation method comprises the following steps:
(1) Mixing the effective components of the traditional Chinese medicine in the oil phase, and fully and uniformly stirring to obtain a first mixed phase for standby;
(2) Adding an emulsifying agent and an auxiliary emulsifying agent into the first mixed phase, heating in a water bath, and uniformly stirring to obtain a second mixed phase for later use;
(3) Slowly dripping distilled water into the second mixed phase until clear and transparent microemulsion is formed, and then cooling and standing in a refrigerator for 12-24 hours to obtain primary mixed solution for later use;
(4) Adding the rest distilled water into the primary mixed solution, and stirring to obtain the hair growth promoting Chinese medicinal liniment.
4. The method for preparing the hair-loss preventing and hair-growing traditional Chinese medicine liniment according to claim 3, which is characterized in that: the temperature of the water bath in the step (2) for heating and stirring uniformly is 40+/-2 ℃, the stirring rotating speed is 120r/min, and the stirring time is 30-50min.
5. The method for preparing the hair-loss preventing and hair-growing traditional Chinese medicine liniment according to claim 3, which is characterized in that: the cooling temperature in the step (3) is 2-4 ℃.
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