CN116806257A - 心肌干细胞/心肌前体细胞的制备方法及心肌纤维化抑制方法 - Google Patents

心肌干细胞/心肌前体细胞的制备方法及心肌纤维化抑制方法 Download PDF

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Publication number
CN116806257A
CN116806257A CN202180070427.7A CN202180070427A CN116806257A CN 116806257 A CN116806257 A CN 116806257A CN 202180070427 A CN202180070427 A CN 202180070427A CN 116806257 A CN116806257 A CN 116806257A
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cardiomyocytes
cells
myocardial
rock inhibitor
cardiomyocyte
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Chinese (zh)
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村中麻生
落谷孝广
马塔·皮尔托-维拉
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Da Vinci Global Ltd
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Da Vinci Global Ltd
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1315—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from cardiomyocytes
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180070427.7A 2020-10-14 2021-10-14 心肌干细胞/心肌前体细胞的制备方法及心肌纤维化抑制方法 Pending CN116806257A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020173581 2020-10-14
JP2020-173581 2020-10-14
PCT/JP2021/038071 WO2022080455A1 (ja) 2020-10-14 2021-10-14 心筋幹／前駆細胞の作製方法及び心筋線維化抑制方法

Publications (1)

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CN116806257A true CN116806257A (zh) 2023-09-26

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CN202180070427.7A Pending CN116806257A (zh) 2020-10-14 2021-10-14 心肌干细胞/心肌前体细胞的制备方法及心肌纤维化抑制方法

Country Status (7)

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US (1) US20230374462A1 (https=)
EP (1) EP4215602A4 (https=)
JP (3) JP7672720B2 (https=)
CN (1) CN116806257A (https=)
CA (1) CA3195608A1 (https=)
TW (1) TW202227615A (https=)
WO (1) WO2022080455A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3062949T3 (en) * 2018-10-15 2026-04-14 Evia Life Sciences Inc Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
CN116536255B (zh) * 2023-07-05 2023-09-12 夏同生物科技(苏州)有限公司 一种高效诱导肌肉干细胞的培养基及方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180273906A1 (en) * 2014-04-17 2018-09-27 Muhammad Ashraf Microvesicle and stem cell compositions for therapeutic applications
JP2018079714A (ja) 2016-11-14 2018-05-24 株式会社ケーヒン 車両用空調装置
JP7298844B2 (ja) 2017-06-05 2023-06-27 テルモ株式会社 細胞培養物の製造方法
WO2020067439A1 (ja) 2018-09-27 2020-04-02 国立大学法人大阪大学 心筋細胞のシート化方法

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Publication number Publication date
US20230374462A1 (en) 2023-11-23
JP2025106563A (ja) 2025-07-15
EP4215602A4 (en) 2024-11-06
JP7672720B2 (ja) 2025-05-08
JP2025106562A (ja) 2025-07-15
CA3195608A1 (en) 2022-04-21
EP4215602A1 (en) 2023-07-26
JPWO2022080455A1 (https=) 2022-04-21
WO2022080455A1 (ja) 2022-04-21
TW202227615A (zh) 2022-07-16

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