CN1167471C - 壳聚糖、胶原和海藻酸钙生物复合无纺布敷料 - Google Patents
壳聚糖、胶原和海藻酸钙生物复合无纺布敷料 Download PDFInfo
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Abstract
本发明公开了一种生物复合无纺布敷料，它由无纺布、壳聚糖、I型胶原、海藻酸钙组成，四者重量配比为：无纺布∶壳聚糖∶胶原∶海藻酸钙为：(75-90)∶(1-10)∶(1-10)∶(0.5-5)。本发明无纺布敷料可用于创面愈合、具有良好的生物相容性、渗透性、弹性和柔韧性可以作为药物的载体，可制作加药敷料，不仅低成本，而且由于改良的生物学性能而便于临床使用。
Description
技术领域
本发明涉及一种医疗器械敷料，尤其涉及一种可以生物降解的无纺布敷料。
背景技术
创面修复是外科乃至整个医学界所面临的最重要、最基本的问题之一。专家们预测，21世纪中，创伤的人数将成倍增长。创面敷料的使用需求也将会面临一个持续上升的新高潮。传统的敷料(纱布)常因血液凝固而附着于伤口面上，换药物时，伤口新生肉芽反复受损坏，延长了伤口愈合时间，给患者也带来了难以忍受的痛苦。随着现代医学，特别是分子生物学的迅速发展，现代研制敷料的概念已发生了根本的变化，即敷料不仅要覆盖创面，还应具有促进组织修复的功能，为新生组织提供生长环境，加速创口愈合、减少疤痕、防止细菌污染；而且用它的可生物降解性，减少了换药的次数。
理想的创面敷料应当具备：(1)与伤口良好的粘附性；(2)类似正常皮肤水分蒸发率的渗透性；(3)具有良好的弹性、柔韧性；(4)阻止细菌入侵和限制细菌在伤口上定殖的屏障功能；(5)减轻疼痛；(6)增进伤口自然愈合过程，不干扰创面的正常愈合机制，不促使肉芽组织过度生长；(7)止血性能；(8)安全性；(9)在创面上稳定，易去除，应用与贮存方便等。至今还没有一种敷料能达到和满足上述要求，都有各自的优缺点。
国内外已发表的研究文献和发明专利显示，用作敷料的无纺布具有良好的透气性和一定的透水性，对创伤起到了包扎、隔离、防护等一定的应急作用。但无纺布本身对伤口不能真正起到治疗作用。对于稍微大的、深的伤口，还要进行二次施药包扎治疗，而且长时间敷贴后，伤口炎症不能及时得到药物有效的治疗，又阻碍了伤口周围血液的正常循环，从而进一步恶化创伤炎症，影响人体健康。
胶原是制作复合生物敷料的常用原料。由于胶原在进化上十分保守，种属间差异很小，因而纯化的胶原有良好的生物相容性，不会引起异物、炎症和排斥反应，并且有较好的生物可降解性。胶原还具有与皮肤相似的粘附性。
壳聚糖从蟹壳、虾皮或真菌的膜中提取并经脱乙酰化而形成的一种多聚糖胺，对机体无毒，与生物体有良好的相容性，易于化学改性，并对许多细菌和真菌有较好的抗菌作用，还有良好的生物可降解性，它透气性好，对创面渗出液吸收性好，对伤口渗血有止血作用，且能促进创面愈合，并可作为药物的缓释载体。但早期粘附性差、顺应性和弹性较差是其缺点。
从褐色海藻中提炼加工而成的海藻酸钙，与创面渗液接触时通过离子交换成可溶性海藻酸钙，后者具有吸收大量液体的能力而发生膨胀起到凝胶作用，并经生物降解溶解在渗液内，湿润时敷料能完整剥离，无纤维残留在创面上。藻酸盐可吸收自身重量20倍的渗液，而纱布仅3-4倍。同时，钙离子释放到伤口诱导血小板活化，产生止血生长因子，起到止血和加速创面愈合的作用。海藻酸钙还具有吸附细菌、阻挡细菌通过的屏障作用，并通过刺激伤口巨噬细胞的活化来增强创面对致病微生物的防御。它的柔韧、顺应性较好，但单独应用时粘附性较差。
发明内容
本发明的目的在于：提供一种可弥补现有技术上述不足的生物相容性、渗透性、弹性和柔韧性的新型生物复合无纺布敷料。
本发明所述的生物复合无纺布敷料由无纺布、壳聚糖、I型胶原、海藻酸钙组成，四者重量配比为：无纺布∶壳聚糖∶胶原∶海藻酸钙为：(75-90)∶(1-10)∶(1-10)∶(0.5-5)。
本发明生物复合无纺布敷料可以作为药物的载体，或制作加药敷料。
本发明生物复合无纺布敷料可用于创面愈合、具有良好的生物相容性、渗透性、弹性和柔韧性，它不仅低成本，而且由于改良的生物学性能而便于临床使用。
具体实施方式
以下结合实施例对本发明进行详细说明。
实施例1
称取壳聚糖1kg和明胶1kg溶于0.05M醋酸至2％(W/V)，加入0.01kg单硬酯酸甘油酯搅匀，用胶体磨将溶液磨成均一液体，再加入缓冲液调整溶液PH值至5-7，在室温下将该溶液搅拌1小时，然后在室温下保温一夜而在无尘气氛中除去溶液中残存的气泡，将8.5kg无纺布浸入此均匀溶液a中。称取0.1kg海藻酸钠倒入研磨，缓缓加入蒸馏水，将海藻酸钠研磨成均一溶液b。再将上述处理的无纺布加入此溶液中，几分钟后再浸入100kg 0.05％氯化钙溶液。取出无纺布，经干燥通道红外灯照射后干燥，再经内外包装后经环氧乙烷照射消毒即可入库。
实施例2
称取壳聚糖1kg和明胶0.8kg溶于0.05M醋酸至2％(W/V)，加入0.01kg单硬酯酸甘油酯搅匀，用胶体磨将溶液磨成均一液体，再加入缓冲液调整溶液PH值至5-7，在室温下将该溶液搅拌1小时，然后在室温下保温一夜而在无尘气氛中除去溶液中残存的气泡，将9kg无纺布浸入此均匀溶液a中。称取0.6kg海藻酸钙倒入研磨，缓缓加入蒸馏水，将海藻酸钙研磨成均一溶液b。再将上述处理的无纺布加入此溶液中，几分钟后再浸入90kg0.05％氯化钙溶液。取出无纺布，经干燥通道红外灯照射后干燥，再经内外包装后经环氧乙烷照射消毒即可入库。
Claims (2)
1、一种生物复合无纺布敷料，其特征在于：由无纺布、壳聚糖，I型胶原及海藻酸钙组成，四者重量配比为：无纺布∶壳聚糖∶胶原∶海藻酸钙为(75-90)∶(1-10)∶(1-10)∶(0.5-5)。
2、根据权利要求1所述的生物复合无纺布敷料，其特征在于：作为药物的载体，或制作加药敷料。
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| CNB021115931A CN1167471C (zh) | 2002-04-29 | 2002-04-29 | 壳聚糖、胶原和海藻酸钙生物复合无纺布敷料 |
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| CNB021115931A CN1167471C (zh) | 2002-04-29 | 2002-04-29 | 壳聚糖、胶原和海藻酸钙生物复合无纺布敷料 |
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| CN1378864A CN1378864A (zh) | 2002-11-13 |
| CN1167471C true CN1167471C (zh) | 2004-09-22 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400019C (zh) * | 2005-03-09 | 2008-07-09 | 中国人民解放军军事医学科学院卫生装备研究所 | 一种急救创伤敷料及其制备方法 |
| CN100423785C (zh) * | 2004-11-16 | 2008-10-08 | 周广刚 | 液体敷料 |
| EA026104B1 (ru) * | 2015-04-02 | 2017-03-31 | Общество С Ограниченной Ответственностью "Тектум" | Кровоостанавливающее и ранозаживляющее средство |
| US10421777B2 (en) | 2016-01-14 | 2019-09-24 | Amnivor Medicare Private Limited | Process for extraction of fish collagen and formulations of 3D matrices of collagen for biomedical and therapeutic applications thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102049061A (zh) * | 2010-12-08 | 2011-05-11 | 苏州同科生物材料有限公司 | 一种壳聚糖胶原海绵烧伤敷料的制备方法 |
| CN102579194A (zh) * | 2012-03-07 | 2012-07-18 | 苏州美迪斯医疗运动用品有限公司 | 功能性生物敷料复合自粘弹性绷带 |
| CN108339150A (zh) * | 2018-05-09 | 2018-07-31 | 浙江海洋大学 | 一种日本黄姑鱼鱼皮胶原蛋白/藻酸盐复合海绵的制备方法 |
| CN110075347B (zh) * | 2019-05-19 | 2021-12-03 | 青岛海之林生物科技开发有限公司 | 一种水溶海藻活性钙-壳寡糖-多肽水凝胶及其制备方法 |
-
2002
- 2002-04-29 CN CNB021115931A patent/CN1167471C/zh not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423785C (zh) * | 2004-11-16 | 2008-10-08 | 周广刚 | 液体敷料 |
| CN100400019C (zh) * | 2005-03-09 | 2008-07-09 | 中国人民解放军军事医学科学院卫生装备研究所 | 一种急救创伤敷料及其制备方法 |
| EA026104B1 (ru) * | 2015-04-02 | 2017-03-31 | Общество С Ограниченной Ответственностью "Тектум" | Кровоостанавливающее и ранозаживляющее средство |
| US10421777B2 (en) | 2016-01-14 | 2019-09-24 | Amnivor Medicare Private Limited | Process for extraction of fish collagen and formulations of 3D matrices of collagen for biomedical and therapeutic applications thereof |
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| CN1378864A (zh) | 2002-11-13 |
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