CN116710553A - SARS-CoV-2刺突糖蛋白结合核酸分子、SARS-CoV-2检测用传感器、SARS-CoV-2检测试剂、SARS-CoV-2的检测方法和SARS-CoV-2病毒的灭活剂 - Google Patents

SARS-CoV-2刺突糖蛋白结合核酸分子、SARS-CoV-2检测用传感器、SARS-CoV-2检测试剂、SARS-CoV-2的检测方法和SARS-CoV-2病毒的灭活剂 Download PDF

Info

Publication number
CN116710553A
CN116710553A CN202180077368.6A CN202180077368A CN116710553A CN 116710553 A CN116710553 A CN 116710553A CN 202180077368 A CN202180077368 A CN 202180077368A CN 116710553 A CN116710553 A CN 116710553A
Authority
CN
China
Prior art keywords
cov
sars
nucleic acid
acid molecule
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180077368.6A
Other languages
English (en)
Chinese (zh)
Inventor
皆川宏贵
藤田智子
加藤信太郎
稻熊婀主魅
堀井克纪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NEC Solution Innovators Ltd
Original Assignee
NEC Solution Innovators Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NEC Solution Innovators Ltd filed Critical NEC Solution Innovators Ltd
Publication of CN116710553A publication Critical patent/CN116710553A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/335Modified T or U
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/165Coronaviridae, e.g. avian infectious bronchitis virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/10Detection of antigens from microorganism in sample from host
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN202180077368.6A 2020-11-30 2021-09-22 SARS-CoV-2刺突糖蛋白结合核酸分子、SARS-CoV-2检测用传感器、SARS-CoV-2检测试剂、SARS-CoV-2的检测方法和SARS-CoV-2病毒的灭活剂 Pending CN116710553A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020198556 2020-11-30
JP2020-198556 2020-11-30
PCT/JP2021/034667 WO2022113496A1 (ja) 2020-11-30 2021-09-22 SARS-CoV-2スパイク糖タンパク質結合核酸分子、SARS-CoV-2検出用センサ、SARS-CoV-2検出試薬、SARS-CoV-2の検出方法、およびSARS-CoV-2ウイルスの不活性化剤

Publications (1)

Publication Number Publication Date
CN116710553A true CN116710553A (zh) 2023-09-05

Family

ID=81755498

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180077368.6A Pending CN116710553A (zh) 2020-11-30 2021-09-22 SARS-CoV-2刺突糖蛋白结合核酸分子、SARS-CoV-2检测用传感器、SARS-CoV-2检测试剂、SARS-CoV-2的检测方法和SARS-CoV-2病毒的灭活剂

Country Status (5)

Country Link
US (1) US20240002860A1 (https=)
EP (1) EP4253545A4 (https=)
JP (1) JP7609468B2 (https=)
CN (1) CN116710553A (https=)
WO (1) WO2022113496A1 (https=)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018051580A1 (ja) 2016-09-15 2018-03-22 Necソリューションイノベータ株式会社 ヌクレオシド誘導体またはその塩、ポリヌクレオチドの合成試薬、ポリヌクレオチドの製造方法、ポリヌクレオチド、および結合核酸分子の製造方法
JP7348754B2 (ja) 2019-06-03 2023-09-21 キヤノン株式会社 画像処理装置及びその制御方法、プログラム、記憶媒体
CN111849994B (zh) * 2020-03-31 2021-11-16 厦门大学 SARS-CoV-2 S蛋白或RBD蛋白的核酸适配体及其应用

Also Published As

Publication number Publication date
WO2022113496A1 (ja) 2022-06-02
US20240002860A1 (en) 2024-01-04
JP7609468B2 (ja) 2025-01-07
EP4253545A1 (en) 2023-10-04
JPWO2022113496A1 (https=) 2022-06-02
EP4253545A4 (en) 2024-06-19

Similar Documents

Publication Publication Date Title
Kawakami et al. In vitro selection of aptamers that act with Zn2+
Nieuwlandt et al. In vitro selection of RNA ligands to substance P
KR102348283B1 (ko) 멀티앱타머 표적 검출
Hirao et al. DNA aptamer generation by ExSELEX using genetic alphabet expansion with a mini-hairpin DNA stabilization method
JP3463098B2 (ja) モジュレートアプタマー及びこれを用いた標的タンパク質の検出方法
JP2007195560A (ja) 核酸リガンド
US10538771B2 (en) Compositions and methods for detecting microorganisms
BRPI9809433B1 (pt) moléculas de dna enzimáticas
US20200340042A1 (en) In vitro selection for nucleic acid aptamers
JP2012198225A (ja) 標的分子の検出法
KR20170040263A (ko) 열불안정성 엑소뉴클레아제
CA2828286A1 (en) Aptamers for clostridium difficile diagnostics
Ma et al. Synthetic genetic polymers: advances and applications
US10760084B2 (en) α-amylase-binding nucleic acid molecule and use thereof
EP1642978A1 (en) Method of detecting sars coronavirus
Yakimovich et al. Influence of DNA aptamer structure on the specificity of binding to Taq DNA polymerase
Yoon et al. A novel ultrasensitive RNase H assay based on phosphorothioated-terminal hairpin formation and self-priming extension reaction
Bing et al. G-quadruplex DNA aptamers generated for systemin
Naimuddin et al. Selection‐by‐function: efficient enrichment of cathepsin E inhibitors from a DNA library
CN118460647B (zh) 一种Patisiran的制备方法
CN116710553A (zh) SARS-CoV-2刺突糖蛋白结合核酸分子、SARS-CoV-2检测用传感器、SARS-CoV-2检测试剂、SARS-CoV-2的检测方法和SARS-CoV-2病毒的灭活剂
KR20240133744A (ko) 표적 분석물의 변이체를 검출하기 위한 앱타머, 이의 제조 방법 및 용도
KR101237858B1 (ko) 살모넬라 엔타라이티디스에 특이적인 앱타머 및 그 응용
US12359248B2 (en) Enzymatic methods to generate high yields of sequence specific RNAs with extreme precision
Ellington et al. Combinatorial methods: aptamers and aptazymes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination