CN116635052A - 用于调节分化簇iv和/或viii的生物工程t细胞介导的免疫、材料和其他方法 - Google Patents

用于调节分化簇iv和/或viii的生物工程t细胞介导的免疫、材料和其他方法 Download PDF

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Publication number
CN116635052A
CN116635052A CN202180083729.8A CN202180083729A CN116635052A CN 116635052 A CN116635052 A CN 116635052A CN 202180083729 A CN202180083729 A CN 202180083729A CN 116635052 A CN116635052 A CN 116635052A
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China
Prior art keywords
cdr1
amino acid
cdr3
cdr2
seq
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CN202180083729.8A
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English (en)
Chinese (zh)
Inventor
R·甘尼桑
S·辛格
I·S·格雷沃
M·R·汉森
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Janssen Biotech Inc
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Janssen Biotech Inc
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Publication of CN116635052A publication Critical patent/CN116635052A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202180083729.8A 2020-10-13 2021-10-12 用于调节分化簇iv和/或viii的生物工程t细胞介导的免疫、材料和其他方法 Pending CN116635052A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063091078P 2020-10-13 2020-10-13
US63/091078 2020-10-13
PCT/US2021/054487 WO2022081516A1 (en) 2020-10-13 2021-10-12 Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv &/or viii

Publications (1)

Publication Number Publication Date
CN116635052A true CN116635052A (zh) 2023-08-22

Family

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CN202180083729.8A Pending CN116635052A (zh) 2020-10-13 2021-10-12 用于调节分化簇iv和/或viii的生物工程t细胞介导的免疫、材料和其他方法

Country Status (10)

Country Link
US (1) US11926667B2 (https=)
EP (1) EP4228693A4 (https=)
JP (1) JP2023544890A (https=)
KR (1) KR20230086765A (https=)
CN (1) CN116635052A (https=)
AR (1) AR123767A1 (https=)
CA (1) CA3198590A1 (https=)
TW (1) TW202231292A (https=)
UY (1) UY39467A (https=)
WO (1) WO2022081516A1 (https=)

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US20220112288A1 (en) 2022-04-14
US11926667B2 (en) 2024-03-12
JP2023544890A (ja) 2023-10-25
AR123767A1 (es) 2023-01-11
EP4228693A4 (en) 2024-12-18
CA3198590A1 (en) 2022-04-21
TW202231292A (zh) 2022-08-16
KR20230086765A (ko) 2023-06-15
UY39467A (es) 2022-04-29
EP4228693A1 (en) 2023-08-23
WO2022081516A1 (en) 2022-04-21

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