CN116625780A - Liquid-based cytology dyeing equipment - Google Patents

Abstract

The invention discloses liquid-based cytology staining equipment, and relates to the technical field of cell staining. The liquid-based cytology staining equipment comprises a base, a sample area, a first TIP head area, a second TIP head area, a reagent cabin area, a centrifugal area, a reaction area and a mechanical arm. The sample zone, the first TIP head zone, the second TIP head zone, the reagent bin zone, the centrifugal zone and the reaction zone are all arranged on the base, and the base is provided with a bracket; the sample area, the first TIP head area, the centrifugal area, the reaction area and the reagent bin area are sequentially arranged along the transverse direction of the base, and the second TIP head area is arranged at the side part of the reaction area; the mechanical arm is used for grabbing the TIP head, and the mechanical arm is movably arranged on the support, and the moving range of the mechanical arm covers the range of the base. The liquid-based cytology dyeing equipment has reasonable layout and compact structure, and the mechanical arm moves for one circle to finish the whole dyeing treatment operation, so that the use is simple, the time required by the mechanical arm to work is effectively shortened, and the working efficiency of the liquid-based cytology dyeing equipment is greatly improved.

Description

Liquid-based cytology dyeing equipment

Technical Field

The invention relates to the technical field of cell staining, in particular to liquid-based cytology staining equipment.

Background

In the related art, most of staining apparatuses can perform operations such as film-making, chemical staining and Papanicolaou staining on the same apparatus, and generally, one staining apparatus needs to be provided with a sample area for placing a cell sample, a TIP head for sucking the sample, a TIP head for sucking a reagent, etc. as an apparatus or structure for operation to satisfy the requirement of staining a cell sample, however, in many cases, the above parts are arranged in a dispersed manner on different apparatuses, and an operator needs to search for the staining operation of a cell sample according to the order of use.

In summary, how to improve the current situations of low dyeing operation efficiency and inconvenience is a problem to be solved by those skilled in the art.

Disclosure of Invention

Therefore, the invention aims to provide the liquid-based cytology staining equipment which has reasonable layout, compact structure and simple and convenient use and greatly improves the working efficiency of the liquid-based cytology staining equipment.

In order to achieve the above object, the present invention provides the following technical solutions:

a liquid-based cytological staining apparatus comprising:

a sample zone for placing a cell sample to be stained;

a first TIP head region for placing a TIP head for sucking a cell sample;

a second TIP head region for placing a TIP head for sucking a reagent;

the reagent bin area is used for placing a reagent bottle containing a dyeing reagent;

the centrifugal area is used for carrying out centrifugal treatment on the cell sample;

a reaction zone for receiving a cell sample for staining thereof;

the sample zone, the first TIP head zone, the second TIP head zone, the reagent bin zone, the centrifugal zone and the reaction zone are all arranged on the base, and the base is provided with a bracket;

the sample area, the first TIP head area, the centrifugal area, the reaction area and the reagent bin area are sequentially distributed along the transverse direction of the base, and the second TIP head area is arranged at the side part of the reaction area;

the mechanical arm is used for grabbing the TIP head, the mechanical arm is movably arranged on the support, and the moving range of the mechanical arm covers the range of the base.

Preferably, the centrifugal device further comprises a waste liquid zone for collecting waste liquid, wherein the waste liquid zone is arranged on the base and is positioned at the side part of the centrifugal zone.

Preferably, the sample area comprises a first placing plate and a first sliding rail, the first sliding rail is longitudinally arranged on the base, the first placing plate is slidably arranged on the first sliding rail, and the first placing plate is provided with a plurality of stations for placing reagent bottles containing cell samples;

and/or, the reagent bin area comprises a second placing plate and a second sliding rail, the second sliding rail is longitudinally arranged on the base, the second placing plate is slidably arranged on the second sliding rail, and the first placing plate is provided with a plurality of stations capable of containing reagent bottles.

Preferably, the first TIP head region includes a third placing plate, the third placing plate has a plurality of through holes into which the TIP heads for sucking the cell samples are inserted, and the third placing plate is fixedly connected with the first placing plate.

Preferably, the sample area further comprises a first cover plate and a first hinge, the first cover plate is used for fixing a reagent bottle placed on the first placing plate, one end of the first cover plate is rotatably connected with the first placing plate through the first hinge, and the first cover plate is provided with a plurality of avoidance ports corresponding to stations of the first placing plate;

and/or, the first hinge is a damping hinge;

and/or the other end of the first cover plate is connected with the first placing plate in an openable and closable way through a hasp.

Preferably, a magnet for attracting to fix the first placing plate is arranged at one end of the first sliding rail, and a first handle is arranged at one end of the first placing plate far away from the magnet;

and/or the reagent bin area further comprises a liquid mixing groove, wherein the liquid mixing groove is positioned at one end of the second placing plate, and a second handle is arranged at the other end of the second placing plate.

Preferably, the centrifugal area comprises a shell, a second cover plate and a second hinge, wherein the second cover plate is rotatably connected with the shell through the second hinge;

and/or, the second hinge is a damping hinge.

Preferably, the reaction zone comprises a fourth holding plate, a slide, and an incubation chamber;

the fourth placing plate is arranged on the base and provided with a plurality of stations for placing the slide;

the slide has two stations for supporting and securing the incubation chamber.

Preferably, the bottom of the incubation bin is provided with opposite clamping parts, and clamping grooves which can be matched with the clamping parts are formed in two sides of each station of the fourth placing plate.

Preferably, the mechanical arm comprises a support member, a first vertical moving component and a second vertical moving component, wherein the first vertical moving component is used for driving a first TIP head mounting column capable of grabbing and sucking a cell sample TIP head, the second vertical moving component is used for driving a second TIP head mounting column capable of grabbing and sucking a reagent TIP head, and the first vertical moving component and the second vertical moving component are both arranged on the support member;

the support is provided with a transverse first sliding rail, the first sliding rail is provided with a slidable and longitudinal second sliding rail, and the supporting piece is slidably arranged on the second sliding rail.

The liquid-based cytology staining equipment provided by the invention has the advantages that the base is the support of other components, and the bracket is a convex structure on the base; the sample zone, the first TIP head zone, the centrifugal zone, the reaction zone and the reagent bin zone are transversely and continuously arranged, the second TIP head zone is positioned on the side surface of the reaction bin zone, and optionally, one end of the second TIP head zone is abutted with the side surface of the reagent bin zone; the mechanical arm has two functions, namely, grabbing the TIP head of the first TIP head area, grabbing the TIP head of the second TIP head area, and moving along the support, so that the free end of the mechanical arm can reach any position of the base.

When the liquid-based cytology staining equipment is used for staining a cell sample, the position of a mechanical arm is adjusted, the mechanical arm firstly grabs a TIP for sucking the cell sample in a first TIP area, the cell sample is sucked in the sample area through the TIP, the TIP sucked with the cell sample is adjusted to the position of a centrifugal area, the cell sample is placed in the centrifugal area, after the cell sample is subjected to centrifugal operation, the TIP sucks the cell sample, and the cell sample is placed in a preset position of a reaction area or an incubation bin at the preset position under the drive of the mechanical arm; then, the mechanical arm goes to the second TIP head area to grab the TIP head for sucking the reagent, the reagent is injected into the preset position of the reaction bin or the incubation bin at the preset position, and the staining treatment of the cell sample is completed through the preset time.

The liquid-based cytology dyeing equipment is reasonable in layout and compact in structure, when the liquid-based cytology dyeing equipment is used, the mechanical arm works from left to right, a cell sample is placed into the reaction bin, then moves to the second TIP head area positioned on the side surface of the reaction area and the reagent bin area positioned on the side surface of the second TIP head area, after the reagent required by dyeing is absorbed, the reagent is injected into the preset position of the reaction area or the incubation bin at the preset position, the mechanical arm moves for one circle to complete the whole dyeing operation, the use is simple and convenient, the time required by the mechanical arm to work is effectively shortened, and the working efficiency of the liquid-based cytology dyeing equipment is greatly improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only embodiments of the present invention, and that other drawings can be obtained according to the provided drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of an embodiment of the present invention;

FIG. 2 is a first partial schematic view of an embodiment of the present invention;

FIG. 3 is a second partial schematic view of an embodiment of the present invention;

FIG. 4 is a schematic view of the structure of a reaction zone according to an embodiment of the present invention;

FIG. 5 is a schematic illustration of a portion of a reaction zone according to an embodiment of the present invention;

FIG. 6 is a schematic view of a fourth placement plate according to an embodiment of the present invention;

FIG. 7 is a cross-sectional view A-A of a fourth placement plate according to an embodiment of the present invention;

FIG. 8 is a schematic illustration of a robotic arm according to an embodiment of the present invention;

fig. 9 is a schematic view of another angle of the mechanical arm according to an embodiment of the present invention.

In fig. 1 to 9, reference numerals include:

the first and second slide rails are a second handle, and the first and second slide rails are a first and second cover plates the third handle 74, the clamping portion 75, the mechanical arm 8, the support 81, the first vertical moving component 82, the first TIP head mounting column 821, the first power source 822, the first lead screw 823, the first sliding block 824, the third sliding rail 825, the first lifting component 826, the second vertical moving component 83, the second TIP head mounting column 831, the second power source 832, the second lead screw 833, the second sliding block 834, the fourth sliding rail 835, the second lifting component 836, the waste liquid area 9, the first sliding rail 10, and the second sliding rail 11.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

The core of the invention is to provide the liquid-based cytology staining equipment which has reasonable layout, compact structure and simple and convenient use, and greatly improves the working efficiency of the liquid-based cytology staining equipment.

Referring to fig. 1 to 9, the present invention provides a liquid-based cytology staining apparatus comprising a base 1, a sample area 2, a first TIP head area 3, a second TIP head area 4, a reagent cartridge area 5, a centrifugation area 6, a reaction area 7 and a robotic arm 8.

Wherein the sample area 2 is used for placing a cell sample to be stained; the first TIP head area 3 is used for placing a TIP head for sucking a cell sample; the second TIP head area 4 is used for placing a TIP head for sucking the reagent; the reagent bin area 5 is used for placing a reagent bottle containing a dyeing reagent; the centrifugal area 6 is used for carrying out centrifugal treatment on the cell sample; the reaction zone 7 is used for accommodating a cell sample for staining; the sample area 2, the first TIP head area 3, the second TIP head area 4, the reagent bin area 5, the centrifugal area 6 and the reaction area 7 are all arranged on the base 1, and the base 1 is provided with a bracket; the sample area 2, the first TIP head area 3, the centrifugal area 6, the reaction area 7 and the reagent bin area 5 are sequentially arranged along the transverse direction of the base 1, and the second TIP head area 4 is arranged at the side part of the reaction area 7; the mechanical arm 8 is used for grabbing the TIP head, the mechanical arm 8 is movably arranged on the support, and the moving range of the mechanical arm 8 covers the range of the base 1.

Specifically, as shown in fig. 1, the base 1 is a support for other components, and the bracket is a convex structure on the base 1; the sample area 2, the first TIP head area 3, the centrifugal area 6, the reaction area 7 and the reagent bin area 5 are transversely and continuously arranged, the second TIP head area 4 is positioned on the side surface of the reaction bin area, and optionally, one end of the second TIP head area 4 is abutted against the side surface of the reagent bin area 5; the mechanical arm 8 has two functions, one is used for grabbing the TIP head of the first TIP head area 3, the other is used for grabbing the TIP head of the second TIP head area 4, and optionally, the mechanical arm 8 is provided with grabbing heads matched with two or more TIP heads, the mechanical arm 8 can slide transversely or longitudinally and can vertically lift, so that sliding in all directions around each area and lifting reaching a preset height during working can be realized, or the mechanical arm 8 is an anthropomorphic flexible mechanical arm, the mechanical arm 8 is rotatably arranged on a support, the mechanical arm 8 can slide along the support, and therefore a gripper of the mechanical arm 8 can reach any position of the base 1 to grab the TIP head.

In this context, the lateral direction refers to the X direction shown in fig. 1, the longitudinal direction refers to the Y direction shown in fig. 1, and the vertical direction refers to the Z direction shown in fig. 1.

Preferably, the sample area 2, the first TIP head area 3, the second TIP head area 4, the reagent chamber area 5, the centrifugal area 6, the reaction area 7 and the like are rectangular areas, and adjacent sides between adjacent areas are arranged in parallel, so that the structure is simple, regular and compact.

When the liquid-based cytology staining equipment is used for staining a cell sample, the position of the mechanical arm 8 is adjusted, the mechanical arm 8 firstly grabs a TIP head for sucking the cell sample in the first TIP head area 3, the cell sample is sucked in the sample area 2 through the TIP head, the TIP head sucked with the cell sample is adjusted to the position of the centrifugal area 6, the cell sample is placed in the centrifugal area 6, after the cell sample is subjected to centrifugal operation, the TIP head sucks the cell sample, and the cell sample is placed in the preset position of the reaction area 7 or the incubation bin 73 of the preset position under the drive of the mechanical arm 8; then, the mechanical arm 8 goes to the second TIP head area 4 to grasp the TIP head for sucking the reagent, the reagent is injected into the reaction chamber at a preset position or the incubation chamber 73 at a preset position, and the staining process of the cell sample is completed by a preset time. The liquid-based cytology dyeing equipment is reasonable in layout and compact in structure, when the liquid-based cytology dyeing equipment is used, the mechanical arm 8 works from left to right, a cell sample is put into the reaction bin and then moves to the second TIP head area 4 positioned on the side surface of the reaction area 7 and the reagent bin area 5 positioned on the side surface of the second TIP head area 4, reagents required by dyeing are sucked and then injected into the preset position of the reaction area 7 or the incubation bin 73 at the preset position, the liquid-based cytology dyeing equipment is reasonable in layout and compact in structure, the mechanical arm 8 moves for one circle to finish the whole dyeing treatment operation, the operation is simple and convenient to use, the time required by the operation of the mechanical arm 8 is effectively shortened, and the working efficiency of the liquid-based cytology dyeing equipment is greatly improved.

On the basis of the above embodiment, the centrifugal device further comprises a waste liquid area 9 for collecting waste liquid, wherein the waste liquid area 9 is arranged on the base 1 and is positioned on the side of the centrifugal area 6.

Specifically, as shown in fig. 1, the waste liquid area 9 has one or more grooves capable of containing liquid, the waste liquid area 9 is located at the side of the centrifugal area 6, and the waste liquid area 9 and the second TIP head area 4 are located at the same side, and optionally, two ends of the waste liquid area 9 are respectively abutted against the second TIP head area 4 and the first TIP head area 3, so that the TIP head can be replaced by the first TIP head area 3 or the second TIP head area 4 where the TIP head is located after the residual reagent or sample cells in the TIP head are injected into the waste liquid area 9, and the time required by the operation of the mechanical arm 8 is effectively shortened.

Based on the above embodiment, the sample area 2 includes the first placing plate 21 and the first slide rail 22, the first slide rail 22 is longitudinally arranged on the base 1, the first placing plate 21 is slidably arranged on the first slide rail 22, the first placing plate 21 has a plurality of stations for placing reagent bottles containing cell samples, so that the liquid-based cytology staining apparatus can store various types of cell samples, such as gynecological cell samples and non-gynecological cell samples, in a diversified manner; and/or, reagent storehouse district 5 includes that the second is placed board 51 and second slide rail 52, and the second slide rail 52 sets up in base 1 along vertical, and the second is placed board 51 slidable and is set up in second slide rail 52, and first board 21 of placing has a plurality of stations that can hold reagent bottle of reagent, so set up, this liquid-based cytology staining apparatus can diversified deposit various reagents, and with sample district 2 cooperation operating personnel can freely select to carry out the staining process to different kinds of cell sample.

Specifically, as shown in fig. 2, the first placing plate 21 may be a plate-shaped structure or a block-shaped structure, and a plurality of through holes are formed on the first placing plate 21 as stations for inserting reagent bottles for holding cell samples, and optionally, each station may be arranged in a rectangular array or in a staggered arrangement; the first slide rail 22 is arranged on the base 1, optionally, four support leg structures are arranged at preset positions of the base 1, the first slide rail 22 is supported by two support leg structures, or two first slide rails 22 are arranged, the other first slide rail 22 is supported by the other two support leg structures, and the two first slide rails 22 are parallel, so that the first placing plate 21 can be pulled out or pushed in along the length direction of the first slide rail 22, and an operator can conveniently place a cell sample.

Similarly, a plurality of through holes are formed in the second placing plate 51 as stations for inserting reagent bottles for containing reagents, and the second sliding rail 52 is arranged on the base 1, so that the second placing plate 51 can be pulled out or pushed in along the length direction of the second sliding rail 52, and an operator can conveniently place the reagent bottles.

The first placing plate 21, the first slide rail 22, and the second placing plate 51, the second slide rail 52 of the reagent cartridge area 5 of the sample area 2 may be provided at the same time, or only one of them may be provided.

On the basis of the above embodiment, the first TIP head section 3 includes the third placing plate 31, the third placing plate 31 has a plurality of through holes into which TIP heads for sucking up the cell samples are inserted, and the third placing plate 31 is fixedly connected with the first placing plate 21.

Specifically, as shown in fig. 2, a plurality of through holes are formed on the third placing plate 31 as stations for inserting the TIP head for sucking the cell sample, the third placing plate 31 is fixedly connected with the first placing plate 21, and the third placing plate 31 and the adjacent side edge of the first placing plate 21 can be fixed by adopting a mode of bolting or welding, etc., so that the first placing plate 21 is pulled out or pushed in along the length direction of the second sliding rail 52, and meanwhile, the third placing plate 31 can be pulled out or pushed in synchronously with the first placing plate 21, thereby being convenient for an operator to place the TIP head, and having a simple structure and convenient operation.

On the basis of the above embodiment, the sample area 2 further includes a first cover plate 23 and a first hinge 24, where the first cover plate 23 is used to fix the reagent bottle placed on the first placing plate 21, one end of the first cover plate 23 is rotatably connected with the first placing plate 21 through the first hinge 24, and the first cover plate 23 has a plurality of avoidance ports corresponding to the stations of the first placing plate 21; and/or the first hinge 24 is a damped hinge; and/or the other end of the first cover plate 23 is connected with the first placing plate 21 in an openable and closable manner through a buckle 25.

Specifically, as shown in fig. 2, the first cover plate 23 is in a plate-shaped structure, the bottom surface of the first cover plate 23 is a plane, and the first cover plate 23 is provided with a plurality of through holes as avoiding openings, and the avoiding openings are in one-to-one correspondence with all stations of the first placing plate 21; the rotatable connection is realized through the hinge between the one end of first apron 23 and the first board 21 of placing, during the use, operating personnel holds the other end application of force of first apron 23, drive first apron 23 and be close to first board 21 of placing, until the bottom surface of first apron 23 and the bottle mouth edge butt of reagent bottle, realize the fixed to the reagent bottle, and the TIP needle is direct can directly sample through dodging the mouth, when need changing the reagent bottle, apply reverse force to first apron 23, drive first apron 23 and keep away from first board 21 of placing.

Optionally, a damping hinge is adopted as the hinge between the first cover plate 23 and the first placing plate 21, so that when the first cover plate 23 rotates to any angle, an operator removes pushing force or pulling force, and the first cover plate 23 can stay at the position.

Optionally, set up hasp 25 in the one end that first apron 23 did not set up the hinge, hasp 25 can rotate to predetermineeing the position at first apron 23 after, fix first apron 23 for first apron 23 can not warp at will, so set up, effectively prevent when the sample, place the reagent bottle of cell sample by driving and break away from the normal position, effectively prevent unexpected emergence.

The liquid-based cytology staining apparatus may be provided with a buckle 25 based on a damping hinge, or may be provided with one of them.

On the basis of the above embodiment, one end of the first slide rail 22 is provided with a magnet 26 for attracting to fix the first placing plate 21, and one end of the first placing plate 21 away from the magnet 26 is provided with a first handle 27; and/or, the reagent cartridge area 5 further comprises a liquid mixing tank 53, the liquid mixing tank 53 is positioned at one end of the second placing plate 51, and the other end of the second placing plate 51 is provided with a second handle 54.

Specifically, as shown in fig. 2, the first placing plate 21 is made of a magnetic material, and when the first placing plate 21 is pushed to a preset position along the first sliding rail 22 by arranging the magnet 26 on the base 1 and arranging one end of the hinge on the first placing plate 21, the first placing plate 21 can be easily placed to the preset position under the attraction of the magnet 26; the first handle 27 is fixed to the end of the first placing plate 21 where the hinge is not provided, and an operator can easily push or pull the first placing plate 21 through the first handle 27.

Optionally, as shown in fig. 3, a second handle 54 is arranged at one side of the reagent compartment area 5, and when an operator needs to place or replace a reagent bottle, the operator only needs to pull out the second placing plate 51 through the second handle 54, so that the operation is simple; one or more liquid mixing tanks 53 are arranged on the other side of the reagent bin area 5, the liquid mixing tanks 53 are used for mixing various required reagents, the liquid mixing tanks 53 are arranged adjacent to a reagent bottle area for placing the reagents, and the operation is convenient when the liquid mixing is required, so that the working efficiency is improved.

On the basis of the above embodiment, the centrifugal zone 6 comprises a housing 61, a second cover plate 62 and a second hinge 63, the second cover plate 62 being rotatably connected to the housing 61 by means of the second hinge 63; and/or the second hinge 63 is a damped hinge.

Specifically, as shown in fig. 2, the housing 61 is a slot with an open top, and a hinge is disposed at one side of the top of the housing 61, so that the second cover 62 can rotate relative to the housing 61; preferably, the second hinge 63 adopts a damping hinge, so that the second cover plate 62 can not rotate at will after rotating to any angle to remove pushing force or pulling force, and the operation personnel can use the damping hinge conveniently.

Optionally, an observation window is arranged at the middle position of the cover plate, so that an operator can easily observe the working condition inside the shell 61 through the observation window, the condition of the cell sample can be mastered conveniently, and improper treatment is avoided.

Preferably, as shown in fig. 2, the first hinge 24 and the second hinge 63 are on the same side, and when the first cover plate 23 and the second cover plate 62 need to be pulled or pushed, the operator can complete on one side, so that the operation is convenient.

It should be noted that the types of the first hinge 24 and the second hinge 63, such as hinges or any other types, are not limited as long as the above functions can be achieved.

On the basis of the above embodiment, the reaction zone 7 includes a fourth placing plate 71, a slide 72 and an incubation chamber 73; the fourth placing plate 71 is arranged on the base 1, and the fourth placing plate 71 is provided with a plurality of stations for placing the glass slide 72; the slide 72 has two stations for supporting and securing the incubation chamber 73.

Specifically, as shown in fig. 4, the fourth placing plate 71 has a plurality of stations, each station may be arranged in a rectangular array or in a staggered arrangement, each slide 72 is placed on a corresponding station, and optionally, each station is in a groove structure, and the pulling plate is clamped in the groove; two incubation bins 73 are arranged on each slide 72, the space utilization rate of the fourth placing plate 71 is high, and one fourth placing plate 71 can accommodate more cell samples, so that the efficiency of cell staining treatment is effectively improved.

On the basis of the above embodiment, the bottom of the incubation chamber 73 is provided with opposite clamping parts 75, and two sides of each station of the fourth placing plate 71 are provided with clamping grooves 711 which can be matched with the clamping parts 75.

Specifically, as shown in fig. 5 to 7, the clamping portions 75 disposed at two sides of the incubation bin 73 are matched with the clamping grooves 711 corresponding to two sides of the upper station of the fourth placement plate 71, so that the incubation bin 73 and the fourth placement plate 71 can be detachably connected, and the detachment and replacement of the incubation bin 73 are facilitated.

Optionally, as shown in fig. 1, the fourth placing plate 71 is provided with third handles 74 at opposite sides, so that the fourth placing plate 71 is easily lifted up or down; preferably, the perpendicular lines of the two third handles 74 have an offset distance therebetween, so that the fourth placing plate 71 is effectively prevented from tipping after being lifted.

On the basis of the above embodiment, the mechanical arm 8 includes a support 81, a first vertical moving component 82 and a second vertical moving component 83, wherein the first vertical moving component 82 is used for driving a first TIP mounting column 821 of a TIP capable of grabbing and sucking a cell sample, the second vertical moving component 83 is used for driving a second TIP mounting column 831 of a TIP capable of grabbing and sucking a reagent, and the first vertical moving component 82 and the second vertical moving component 83 are both arranged on the support 81; the support is provided with a first transverse sliding rail 10, the first sliding rail 10 is provided with a second sliding rail 11 which is slidable and longitudinal, and the supporting piece 81 is slidably arranged on the second sliding rail 11.

Specifically, as shown in fig. 1, a first sliding rail 10 is arranged on the bracket along the X direction, and a second sliding rail 11 is arranged on the first sliding rail 10, so that the mechanical arm 8 can move along the second sliding rail 11 in the Y direction, and the second sliding rail 11 slides along the first sliding rail 10, so that the mechanical arm 8 can move along the X direction; as shown in fig. 8 and 9, the supporting member 81 of the mechanical arm 8 can move along the second sliding rail 11, preferably, the supporting member 81 is a plate-shaped structure elongated along the Z direction, has a light weight, and satisfies the length of the vertical movement; the first vertical moving component 82 drives the first TIP head mounting post 821 to move along the Z direction, the second vertical moving component 83 drives the second TIP head mounting post 831 to move along the Z direction, it should be noted that the types of the first vertical moving component 82 and the second vertical moving component 83 may be the same or different, and the first vertical moving component 82 and the second vertical moving component 83 are all disposed on the supporting member 81, so that the supporting member 81 moves to drive the first vertical moving component 82 and the second vertical moving component 83 to move synchronously, and the first vertical moving component 82 and the second vertical moving component 83 have compact structure and small required operation space.

Optionally, the first vertical moving assembly 82 further includes a first power source 822, a first lead screw 823 and a first lifting member 826, specifically, an output shaft of the first power source 822 is coaxially fixed with the first lead screw 823, and a length direction of the first lead screw 823 is a Z direction by adopting welding or a coupling, etc., and when the lead screw passes through the first lifting member 826, the first lead screw 823 rotates to drive the first lifting member 826 to move along the Z direction; in addition, the first vertical moving assembly 82 further includes a first slider 824 and a third slide rail 825, the third slide rail 825 is disposed above the support member 81 along the Z direction, and the first lead screw 823 passes through the first slider 824, so that the first lead screw 823 rotates to drive the first slider 824 to slide along the third slide rail 825, thereby effectively avoiding the first lifting member 826 from yawing.

Similarly, the second vertical moving assembly 83 further includes a second power source 832, a second lead screw 833 and a second lifting member 836, specifically, an output shaft of the second power source 832 is coaxially fixed with the second lead screw 833, the length direction of the second lead screw 833 is the Z direction, the second lead screw 833 passes through the second lifting member 836, and the second lead screw 833 rotates to drive the second lifting member 836 to move along the Z direction; in addition, the second vertical moving assembly 83 further includes a second sliding block 834 and a fourth sliding rail 835, the fourth sliding rail 835 is disposed above the supporting member 81 along the Z direction, and the second lead screw 833 passes through the second sliding block 834, so that the second lead screw 833 can rotate to drive the second sliding block 834 to slide along the fourth sliding rail 835, thereby effectively avoiding the second lifting member 836 from yawing.

Optionally, a code reader is arranged on the support 81, and a bar code or a two-dimensional code is arranged on each reagent bottle in the reagent bin area 5 or at a corresponding position of the reagent bottle, and the position where the reagent needs to be extracted or the type of the sucked reagent can be known to be correct by identifying the bar code or the two-dimensional code through the code reader.

It should be noted that relational terms such as "first" and "second" and the like are used solely to distinguish one entity from another entity without necessarily requiring or implying any actual such relationship or order between such entities; the terms "upper surface, lower surface, top, bottom" and the terms "upper, lower, left, right" are defined above based on the drawings of the specification.

In the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other.

The liquid-based cytology staining apparatus provided by the invention is described in detail above. The principles and embodiments of the present invention have been described herein with reference to specific examples, the description of which is intended only to facilitate an understanding of the method of the present invention and its core ideas. It should be noted that it will be apparent to those skilled in the art that various modifications and adaptations of the invention can be made without departing from the principles of the invention and these modifications and adaptations are intended to be within the scope of the invention as defined in the following claims.

Claims (10)

1. A liquid-based cytological staining apparatus comprising:

a sample zone (2) for placing a sample of cells to be stained;

a first TIP head region (3) for placing a TIP head for sucking a cell sample;

a second TIP head region (4) for placing a reagent-sucking TIP head;

the reagent bin area (5) is used for placing a reagent bottle containing a dyeing reagent;

a centrifugation zone (6) for centrifuging the cell sample;

a reaction zone (7) for receiving a cell sample for staining thereof;

the sample zone (2), the first TIP head zone (3), the second TIP head zone (4), the reagent bin zone (5), the centrifugal zone (6) and the reaction zone (7) are all arranged on the base (1), and the base (1) is provided with a bracket;

the sample zone (2), the first TIP head zone (3), the centrifugal zone (6), the reaction zone (7) and the reagent bin zone (5) are sequentially arranged along the transverse direction of the base (1), and the second TIP head zone (4) is arranged at the side part of the reaction zone (7);

the mechanical arm (8) is used for grabbing the TIP head, the mechanical arm (8) is movably arranged on the support, and the moving range of the mechanical arm (8) covers the range of the base (1).

2. The liquid-based cytological staining apparatus of claim 1 further comprising a waste liquid zone (9) for collecting waste liquid, the waste liquid zone (9) being provided to the base (1) and being located laterally to the centrifugation zone (6).

3. The liquid-based cytological staining apparatus of claim 1 wherein the sample area (2) comprises a first placement plate (21) and a first slide rail (22), the first slide rail (22) being longitudinally disposed on the base (1), the first placement plate (21) being slidably disposed on the first slide rail (22), the first placement plate (21) having a plurality of stations for placing reagent bottles containing cellular samples;

and/or, reagent storehouse district (5) include second place board (51) and second slide rail (52), second slide rail (52) along vertically set up in base (1), second place board (51) slidable set up in second slide rail (52), first place board (21) have a plurality of stations that can hold reagent bottle of reagent.

4. A liquid-based cytological staining apparatus as in claim 3 wherein the first TIP head zone (3) comprises a third placement plate (31), the third placement plate (31) having a plurality of through holes into which the TIP heads for aspirating cell samples are inserted, and the third placement plate (31) is fixedly connected to the first placement plate (21).

5. A liquid-based cytological staining apparatus as in claim 3 wherein the sample area (2) further comprises a first cover plate (23) and a first hinge (24), the first cover plate (23) being for securing a reagent bottle placed on the first placement plate (21), one end of the first cover plate (23) being rotatably connected to the first placement plate (21) by the first hinge (24), the first cover plate (23) having a number of relief openings corresponding to the stations of the first placement plate (21);

and/or, the first hinge (24) is a damped hinge;

and/or the other end of the first cover plate (23) is connected with the first placing plate (21) in an openable and closable way through a hasp (25).

6. A liquid-based cytological staining apparatus as in claim 3 wherein one end of the first slide rail (22) is provided with a magnet (26) for attracting to secure the first placement plate (21), the end of the first placement plate (21) remote from the magnet (26) is provided with a first handle (27);

and/or, the reagent bin area (5) further comprises a liquid mixing groove (53), the liquid mixing groove (53) is positioned at one end of the second placing plate (51), and a second handle (54) is arranged at the other end of the second placing plate (51).

7. The liquid-based cytological staining apparatus of claim 1 wherein the centrifugation area (6) comprises a housing (61), a second cover plate (62) and a second hinge (63), the second cover plate (62) being rotatably connected to the housing (61) by the second hinge (63);

and/or the second hinge (63) is a damped hinge.

8. Liquid-based cytological staining apparatus according to any of claims 1 to 7 wherein the reaction zone (7) comprises a fourth placement plate (71), a slide (72) and an incubation chamber (73);

the fourth placing plate (71) is arranged on the base (1), and the fourth placing plate (71) is provided with a plurality of stations for placing the slide glass (72);

the slide (72) has two stations for supporting and securing the incubation chamber (73).

9. The liquid-based cytological staining apparatus of claim 8 wherein the bottom of the incubation compartment is provided with opposing clamping portions, and the clamping grooves engageable with the clamping portions are provided on both sides of each station of the fourth placement plate.

10. The liquid-based cytological staining apparatus of any of claims 1 to 7 wherein the robotic arm (8) comprises a support (81), a first vertical movement assembly (82), a second vertical movement assembly (83), the first vertical movement assembly (82) for driving a first TIP mounting post (821) for grasping a TIP of a aspirated cell sample, the second vertical movement assembly (83) for driving a second TIP mounting post (831) for grasping a TIP of an aspirated reagent, the first vertical movement assembly (82) and the second vertical movement assembly (83) each being disposed on the support (81);

the support is provided with a transverse first sliding rail (10), the first sliding rail (10) is provided with a slidable and longitudinal second sliding rail (11), and the supporting piece (81) is slidably arranged on the second sliding rail (11).