CN116603009A

CN116603009A - Rhinoceros yellow pill

Info

Publication number: CN116603009A
Application number: CN202310520399.5A
Authority: CN
Inventors: 王晨旭; 王昌勇
Original assignee: Xiamen Eagle Don Pharmaceutical Co ltd
Current assignee: Xiamen Eagle Don Pharmaceutical Co ltd
Priority date: 2023-04-29
Filing date: 2023-04-29
Publication date: 2023-08-18

Abstract

Rhinoceros yellow pill. The Xihuang pill in the Chinese pharmacopoeia is compared with the Xihuang pill in the Qing dynasty Wang Hongxu work, and the Xihuang pill has more than ten defects, spurious and drawbacks; such as rare rhinoceros yellow; expensive musk; vinegar-processed Olibanum and Vinegar-processed Myrrha which cause poisoning due to high bilirubin freeness in calculus bovis; free cholic acid content in low content bilirubin bezoar; millet with low content of enteric matters and low purity and short plates without broad spectrum; and, the uniqueness and uniqueness of the drug due to the disease are limited by the prescription of the drug. The invention picks up leakage and correction as much as possible, and gives the enteric-coated rhinoceros Huang Wanan spectrum, low cost and no toxicity by using biochemical extract, promoting hematouric acid and protease and enzyme activator. The ancient classical prescription similar to the 'magic article' becomes a affordable material and a health-care product for common people.

Description

Rhinoceros yellow pill

Technical Field

The invention relates to the field of traditional Chinese medicine preparations, in particular to a medicine for treating cancers.

Technical Field

Chinese anti-cancer first medicine; the Xihuang pill for detumescence and resolving hard mass is derived from the Xihuang pill in Qing Dynasty Wang Hongxu "surgical Zhi Quansheng Ji", and is inherited for three hundred years.

Rhinoceros yellow pill is also called Xihuang pill in pharmacopoeia of the people's republic of China. The traditional Chinese medicine is listed in the national basic medical insurance item and mainly treats cancer; such as breast cancer, breast fibroma, hyperplasia of mammary glands, cervical cancer, herpes zoster, intestinal cancer, liver cancer, lung cancer, pancreatic cancer, lymph cancer, gastric cancer, esophageal cancer, bone cancer, osteomyelitis, bladder cancer, leukemia, uremia and the like, and the instant effect is obtained.

Prescription: 15g of bezoar, 15g of musk, 550g of vinegar olibanum, 550g of vinegar myrrh and 350g of steamed millet; every 20 pills weight is 1g, every 1g contains bilirubin not less than 1.9mg, and the medicine is orally taken, 3g once and 2 times a day; and a total weight of 1480g.

Although the luteolin pill has remarkable curative effect, the luteolin pill is limited by precious and scarce bezoar, has low yield and cannot be used by the masses, and can only be used for evaluating the medical records in articles and ancient medical books from the papers, journal of books and networks at present, and the doctor records are peeped for '6-16 days, so that the tumor elimination speed is remarkable, and' the tongue is thoroughly healed when the wine is taken. The medicine called "shenlai"; but the cost of the medicinal materials is hard to bear by individuals.

The production of the domestic Xihuang pill is normal by using bezoar in Beijing Tongren Tang; however, the preparation of artificial bezoar containing only 0.63% bilirubin in pharmacopoeia is not normal.

Facing market disorder, the traditional Chinese medicine pharmacist in the industry and the hall, the shop and the shop of the traditional Chinese medicine in the market; and the lovers of the traditional Chinese medicine, especially the high-quality bezoar which is specially prepared into the luteolin pill, are in the high-end population and families. The artificial bezoar containing 0.63% bilirubin in pharmacopoeia is free bilirubin with toxicity; in contrast to covalent bilirubin, bilirubin in artificial bezoar is only the external fur of bezoar, except 0.3-0.7% free bilirubin, which has 25-76% nontoxic binding species; the content of bilirubin in the two is 39.7-120.6 times different.

Prescription of "Zui xi Huang Wan" in Qing- "surgical Zhi quan Sheng Ji" (surgical Condition and Be treated with Sus Domestica): ' two of frankincense and myrrh powder, one of musk, one of five of musk, three of rhinoceros bezoar and one of millet and one of two of millet. The weight in the prescription is converted into the weight until now; then, the frankincense is 37.3g,3.5 yuan; myrrh 37.3g,6.6 yuan; musk 5.6g,6720 yuan, accounting for 83% of the cost of the whole medicinal material; 1.12g of first-class bezoar and 1344 yuan, which account for 17 percent of the cost of the whole medicinal material; 37.3g of yellow rice and 1 yuan; the medicinal material has a value of 8075 yuan, the total weight of 118.62g, and the medicinal material can be taken once a day, 11.2g each time, and 10.6 days.

The two prescriptions are compared with each other. Musk of the auxiliary agent in the ancient prescription is 4.72 times more, and the weight of the bezoar of the main agent is 0.06 percent less than that of the auxiliary agent in the prior prescription; however, the bilirubin content in bezoar is 76% and is higher than 25% of the prior art by 3.04 times, which is more effective, and the clarity is clear; moreover, the Xihuang pill in the "pharmacopoeia" is used for controlling the Rhinoceros yellow pill in the Qingqing Wang Hongxu work, and more than ten different innovation items and eight innovation items which can be discussed and studied are found:

1. bilirubin content in bezoar is insufficient

The "content of bilirubin per 1 g" of Xihuang pills in Chinese pharmacopoeia "of 2020 edition is not less than 1.9mg", namely the legal 15g of bezoar with the content of bilirubin of 18.75%. Then, according to the legal quality standard of bilirubin content not less than 25% in the 'bezoar' of Chinese pharmacopoeia of the same year edition, 15g of the bilirubin is added, and the bilirubin content in the Xihuang pill should not be less than 2.53mg per 1 g. Compared with the two. The difference of 1.33 times of bilirubin is highlighted between the legal requirement of the lowest quality of bezoar and the legal requirement of the patent medicine. And this is only one of the spurious.

2. Content standard of bilirubin in bezoar

Aiming at bezoar per se. Five different designations appear in the definition Wang Hongxu works; "Rhinoceros bezoar, zhenRhinoceros yellow, rhinoceros yellow, western bezoar and bezoar". Why are the same person writing the same book, different designations of bezoar appear? And have "valuable, can't lighten the training of two? The ancient Chinese characters such as gold and the repair are strict, and are not unintentional at all. The ancient books and the papers, monographs, school papers, publications and network articles of the present application are traversed, and the 'Rhinoceros yellow' is interpreted as 'obtained from Rhinoceros' and is known as 'absolute rare'. The bezoar has rare and valuable but not abundant smell, is obviously different from other bezoar, and has abrupt grade difference; it is understood as first-class bezoar in the present reality. I.e., bezoar with high bilirubin levels.

In reality, bezoar in all world is known from pharmacopoeia, monograph and literature, and the bilirubin content is 25% -75%. It can be clearly seen that the phase difference is 3 times from low to high; what may be called a level of stamina is severe and the eye is surprised. In the traditional Chinese medicine industry, the bilirubin content in bezoar is classified into three large grades according to the high, medium and low levels. The content is equal to or more than 65%; 45% or more is equal to or more; more than 25% is three. The terms "about" and "about" refer to "the terms" from noble to plain "and" about "respectively mean" Rhinoceros yellow, calculus bovis and calculus bovis ".

Note that: the content and the time price of bilirubin in bezoar are 25% -35%, 40 ten thousand yuan/Kg; 35% -45%, 60 ten thousand yuan/Kg; 45% -55%, 80 ten thousand yuan/Kg; 55% -65%, 100 ten thousand yuan/Kg; 65% -75%, 120 ten thousand yuan/Kg.

First-class bezoar is rare from ancient times. If the bezoar is not the first-class bezoar, large-scale industrial production cannot be formed, and the bezoar can only be a unique solitary product in the traditional Chinese medicine industry or a specimen in absolute products; it is not at all popular with the public. Therefore, in order to ensure the demanding quality standard of the luteolin pill, the content of bilirubin in the 'luteolin' can only be selected to be consistent; more than 65% of biochemical reaction complex combined with bilirubin and 4% -6% of combined cholic acid is used for replacing 'rhinoceros bezoar'; namely, six conjugates of bilirubin, biliverdin with electrolytes and proteins such as calcium, magnesium, sodium, zinc, etc., covalent bilirubin, four free cholic acids, and six conjugated cholic acids; for example, cholic acid and deoxycholic acid with electrolytes such as calcium, magnesium, sodium, zinc and the like, and amino acids such as glycine, taurine and the like; in particular, see Chinese patent ZL201310697229.0

3. Different dosage

The dosage in Qing dynasty and Wang Hongxu works is 'three times per day, 1 time per day'; the pharmacopoeia is that 3g is orally taken and 2 times daily.

596.82g of Qing dynasty by sixteen times; then, one piece=3.73 g×3 piece=11.2 g, which is 1.87 times higher than 6g taken 2 times daily in pharmacopoeia. As is well known. The medicine diseases are paced like war, and the oil adding war for delaying the towering is a big contraindication; it is also extremely silly and silly, therefore, the shortage of dosage can not result in the wonderful efficacy of "eliminating tumor with a surprise" ten times of taking wine.

4. Takes hot yellow wine as a guide

In Qing dynasty Wang Hongxu, the wine is taken with hot old wine, and sweat is taken from the drunk cover to open the striae; in Qing dynasty, the heat-aged wine in the south of the Yangtze river, namely the modern heat-aged wine, can accelerate blood circulation and promote metabolism; in the prescription concept of 'monarch, minister, assistant and guide' of the traditional Chinese medicine, the function of 'guide' is taken as a main ingredient; of course, when liver is diseased or unable to drink, the hot fermented glutinous rice and hot ginger decoction are used instead, they are also used to open the striae.

5. Treatment course

In Qing dynasty Wang Hongxu works, "three money per service, … …, after toxin is exhausted, one more money is sent every 7 days; and the pharmacopoeia has no requirement for treatment course.

6. Targeted usage

In qing Wang Hongxu, the "upper clinical clothes for sick and born, the" lower hollow clothes ". "upper part of the patient" refers to the head, neck, breast and lung; the quilt can be taken before sleeping at night, and can be used for covering sweat on the lower part, such as liver cancer, pancreatic cancer, cervical cancer, intestinal cancer, etc., and can be taken on an empty stomach after relieving bowels in the morning. The absolute taking method is particularly established for improving the utilization rate and the efficacy of the medicine according to the rule and rule of the operation of internal organs of a human body in traditional Chinese medicine; pharmacopoeia, also without advice.

7. Yang He Tang is an adjuvant therapy

In Qing dynasty Wang Hongxu, the decoction and the Rhinoceros yellow pill are taken in the morning and evening. From the aspect of prescription logic, the yang and the soup take on the role of 'adjuvant'; and clarifies that yang harmonizing decoction is only suitable for patients with yang deficiency; the medical science is known from the pharmacopoeia. Although the yang-harmonizing decoction has definite curative effect, the directivity is extremely definite; and is not broad-spectrum, as it excludes patients with 'yin deficiency'. The complex protease of the inventor has broad spectrum, can improve the nutrition level of patients and ensure the energy consumption and the immunity of the human body; therefore, it is more direct and effective than yang-harmonizing soup.

Yang He Shang Chufang in Qing & Su Zhi Quansheng Ji (surgical Congress of treating surgical syndromes): "radix rehmanniae Preparata one two (37.3 g), herba Ephedrae five (1.87 g), colla cornus cervi three (11.2 g), semen Sinapis Albae two (7.46 g), parched cortex Cinnamomi one (3.73 g), glycyrrhrizae radix one (3.73 g), and rhizoma Zingiberis Preparata charcoal five (1.87 g). Is mainly used for treating bone fracture, deep-rooted carbuncle, gangrene, arthroncus, breast rock, tuberculosis, carbuncle, jaundice, flat collapse, white sinking, yin coagulation, etc. Herba Ephedrae is obtained without release of the rehmannia root, radix rehmanniae Preparata is obtained without stagnation of the herba Ephedrae and is used in this area.

8. Vinegar Olibanum and Vinegar Myrrha

The preparation method is characterized in that the vinegar processed frankincense and myrrh are used as a preparation in the pharmacopoeia, dissociation of the combined bilirubin in the bezoar occurs, so that the degree of dissociation of the bilirubin is increased, and the efficacy of the bezoar is weakened. For this major failure, we have confirmed with practical experiments. According to legal requirements of Chinese pharmacopoeia assay on the degree of freeness of bezoar, the method is to accurately measure 10mg, add 5ml of chloroform, and measure absorbance at 453nm wavelength of a spectrophotometer, then:

(1) 10mg of bezoar, the freeness of which is 0.46; lower than legal 0.7 by 0.24, and is assigned to the list of acceptable products.

(2) Respectively taking 0.373g of the fine powder of the vinegar olibanum and the vinegar myrrh, respectively adding 5ml of chloroform into a test tube, carrying out ultrasonic treatment for 5min to show the state that the vinegar olibanum and the vinegar myrrh are insoluble in the chloroform, centrifuging, taking the chloroform from a needle filter into a cuvette, and measuring the absorbance to obtain 0.05 and 0.03; the vinegar-processed olibanum and the vinegar-processed myrrh are not free in chloroform.

(3) Putting the qualified bezoar into a test tube, and reducing the dosage according to the prescription proportion, wherein the following steps are as follows: adding 0.373g of cow-bezoar with vinegar myrrh, adding 1ml of distilled water, sealing, ultrasonic washing for 5min, centrifuging for 1min, sucking the upper layer washing liquid into another test tube, adding 5ml of chloroform, uniformly mixing by a vortex device for 2min, standing for 2min, taking the chloroform at the bottom layer of the test tube by a needle filter, and measuring the absorbance to obtain 1.45; as can be seen, the degree of dissociation of bezoar increases from 0.46 up to 3.15 times.

(4) Adding 0.373g of vinegar-processed Olibanum, and measuring 0.915 g; as can be seen, the degree of dissociation of bezoar is increased by a factor of 1.99 from 0.46.

(5) Conclusion: the data obtained from both the vinegar-processed olibanum and the vinegar-processed myrrh are added together, except for 2, and rise upwards by 2.57 times on average. The ratio of the ' bezoar not exceeding 0.70 absorbance ' in pharmacopoeia ' is defined by law and is also totally more than 3.67 times. It can be seen that the bezoar undergoes disintegration of its quality under the clamping of vinegar; the magic of "dispelling spirit" is just 'method water' using vinegar.

9. Comparison of dry and wet application effects of millet

The "Zhihuang pill" of pharmacopoeia is, "prescription: "bezoar 15g, musk 15g, frankincense 550g processed with vinegar and myrrh 550g processed with vinegar". Grinding the above four materials, steaming and oven drying 350g of millet, pulverizing into fine powder with vinegar-processed Olibanum and vinegar-processed Myrrha, sieving, mixing with calculus bovis and Moschus powder, sieving, mixing, making into pill with water, and drying in the shade. That is, steamed millet is crushed into powder in dry form together with vinegar-processed frankincense and vinegar-processed myrrh, the rice powder floats on the surface of the formulation, and water is added to the mixture to form pills.

Whereas, qing dynasty Wang Hongxu is "Ruihuang pill of Olibanum and Myrrha is one or two, moschus is one or five, calculus bovis is three, grinding together, taking yellow rice and one or two, mashing, adding into powder, making pill like radish seed, sun drying, and baking. That is, the cooked millet is pasty, is 'stuck' on the formulation at the beginning of the pelleting, is more quantitative, tighter and stronger than the dry method for coating, and has better shielding effect than the dry method; the assay also demonstrates that wet methods have lower degrees of bilirubin freeness than dry methods and that advantages are present.

10. High content of free cholic acid

Another prominent failure point not perceived by current traditional Chinese medicine is that in bezoar with low bilirubin, a large amount of free cholic acid is attached due to its low content; if the medicine is taken continuously for a long time or for a long time, poisoning is caused, and intestinal cancer is promoted. Therefore, the bezoar in the prepared luteolin pill is obtained in a safe way that the total cholic acid content in the bezoar is tested by the national food and drug administration, and the content of four free cholic acids is confirmed on the basis of ten cholic acids; this is a necessary, and also legal, instrument assay to identify scientific quantitative results.

Free bile acid content, the stealth property of bezoar; it was also demonstrated from the other side that Qing Wang Hongxu and its ancestor were not multiplied by the relatively readily available second grade bezoar, or the more readily available third grade bezoar, for reasons of extremely difficult achievement of the first grade bezoar efficacy. A few words of the sentence are white. Namely, the input amount of the 'bezoar' and the 'bezoar' which are lower than the bilirubin content of the 'Rhinoceros bezoar' can not be multiplied, so that the bilirubin content of the 'Rhinoceros yellow' is forcibly achieved, the efficacy of the 'Rhinoceros yellow pill' is pursued, and the Rhinoceros yellow pill is forcibly prepared; therefore, the double increase of bilirubin content also increases the free bile acid content, meaning the risk of causing cachexia is double. This is the root cause of the need to be administered as 'calculus bovis', which is specifically designated by Qing Wang Hongxu and its ancestor pre-ancestor.

And (5) performing example verification. Four lithocholic acids with the smallest ratio among the toxic free cholic acids are exemplified. The content of the extract is naturally and physiologically shown in bezoar, and the extract has curative effects on bronchitis and chronic bronchitis, protects gastric mucosa and intestinal mucosa of patients and prevents mucosal injury; killing brain glioma cells without damaging normal brain nerve cells, and is an extremely effective biochemical medicine aiming at brain tumors. However, the human factor increases the concentration of lithocholic acid in blood, but promotes accumulation of intrahepatic bile, causes formation of liver tumor, and highlights the troublesome condition of pressing the gourd.

Therefore, in practice, except for brain tumor and laryngeal carcinoma, other tumors must be relieved of lithocholic acid; this delicate manual operation can only be achieved with the biochemically reactive bilirubin complex. All leopard is known from looking at a spot. The specific application of the ten cholic acids is that the tumor type must be selected pertinently, and the patient can not be placed in the four seas, and the eyebrow is grasped at one time; it is seen that it is an extremely sharp and classical double edged sword.

Under the condition of rapid situation, the content of free bile acid can be easily and simply, intuitively, clearly and accurately determined according to practical experience in assaying the content of bilirubin in bezoar; therefore, the bilirubin with high content in bezoar occupies the space of the total cholic acid in a great proportion of absolute advantage, so that the four free cholic acids form a proportional content relation physiologically naturally. This is also one of the key factors for three hundred years's forefront Wang Hongxu and its ancestor who identified and exclusively selected ' calculus bovis ' to achieve "helped" success.

Inspired by this pharmacology. In practical application, under the extreme condition that 'rhinoceros bezoar' is obtained from anese, after the bilirubin content of the second-class bezoar purchased in northwest slaughter enterprises is raised by a biochemical extraction method, the second-class bezoar is applied to the rhinoceros yellow pills by the high bilirubin content of the 'rhinoceros yellow', and the remarkable efficacy of the second-class bezoar is also proved. The specific method comprises the following steps:

pulverizing calculus bovis, feeding into Buchner funnel, sequentially and repeatedly pumping and washing with hot methanol and hot ethanol with accurate concentration and pH at low speed, and gradually decreasing alcohol concentration; finally, dehydrating the anhydrous acetone and the anhydrous ethanol in a gradient way, and vacuum drying to obtain the bilirubin content of 65-73%; although the weight loss of the bezoar is huge and the cost is high, the efficacy is obviously better than that of bezoar of the second class or third class.

The free cholic acid in the bezoar is dissolved and washed to be empty, so that two advantages are obtained, and the bad fruits caused by the free cholic acid are not worried any more; secondly, the bezoar can be put into play as soon as possible to prevent and stop the potential of the crazy proliferation of tumor cells and achieve the purposes of fast shrinking tumor and eliminating tumor according to different tumor types, different characters, different physique and other factors, and the like, by manually selecting the types and dosages of cholic acid to obtain the first opportunity.

The artificial quality of the extreme 'rhinoceros bezoar' also creates a certain vector-placing accuracy; for example, the extreme quality of cholic acid such as lithocholic acid is deleted and reserved to target intestinal cancer and brain tumor respectively; even the pancreatic cancer of the king in cancer has a unique 'symptomatic' advantage, i.e., pursuing the Chinese medicine "symptomatic eating a dose, not symptomatic marine" to the high world.

11. Volatile oil in olibanum and myrrh

The olibanum and the myrrh are processed to alleviate the stimulation of light volatile oil, so that vomiting, abdominal pain and loose stool after gastrointestinal cramp are easy to cause due to raw use; but it is used for life, and has strong actions of activating blood, resolving stasis and relieving pain.

Olibanum and Myrrha in the formula qing Wang Hongxu are prepared by parching with medulla Junci. If the biochemical pharmaceutical principle is adopted, the rush core with high adsorptivity adsorbs volatile free acid, and side effect is reduced. However, the yield of the frankincense and the myrrh prepared by the medulla Junci is only 55%, and the loss is huge.

The inventor prepares the frankincense and the myrrh by short-time microwave radiation and coats the frankincense and the myrrh by enteric materials, thereby obtaining the advantages of half and multiple functions of raw use and processing. That is, not only the stimulation of the light volatile oil is eased, but also the consequences of irreversible neurotoxicity caused by the large dissociation of light myrrh acid and olibanic acid from the combined bilirubin are avoided, and the high yield and efficacy are ensured. There is also a more important point. The two original ecological biological medicines are not produced in China and are imported from abroad. In recent years, the occurrence of various viruses is very worry about import materials; and the sterilization and disinfection can be extremely effectively realized by strong radiation of microwaves.

For both biological agents. Patients with poor immunity and physical allergies are easy to generate allergic reactions such as fever, poor sleep, redness, itching, erythema, dysphoria, red and swollen ears and the like; in addition, the patients with poor digestion and absorption functions and intestinal ulcer can not take the medicine, and the medicine should be replaced by biochemical extracts of dragon's blood, radix curcumae, turmeric, achyranthes root, trogopterus dung, herba lycopi, suberect spatholobus stem, rhizoma ligustici wallichii, radix salviae miltiorrhizae and the like corresponding to different tumors and constitutions after deleting.

12. Musk

Musk is produced from male musk, also called as a river deer. In ancient times, the feed is a common animal, has multiple species, large group and rich resources; modern musk feeding is also scaled. Although musk yield in China is 70% of the world and is easier to obtain than bezoar, the biological medicine is extremely expensive, and the cost of the biological medicine is 83% of the cost of the whole rhinoceros Huang Wanyao material.

From the prescription of the Rhinoceros yellow pill in Qing dynasty- "surgical Zhengzhi quansheng Ji"; it is known that the intrinsic value and efficacy are far lower than those of 'rhinoceros bezoar'.

The artificial musk in the pharmacopoeia is very cheap; however, there are commercially available musks prepared by blending cyclopentadecanolide, 3-methylcyclopentadecanone, etc. which are synthesized by artificial chemistry. Other finished products of artificial chemical synthetic musk are also available; such as sunflower musk, xylene musk, musk cymene, musk ketone, musk, etc., which are all natural and wonderful in the industry; medium-grade testing instruments such as liquid phase and gas phase are difficult to distinguish in quality. More worry is that these artificial compositions, without exception, all have oncogenic properties; and in the European and American countries where perfume is prevalent, residual hazards in metabolites have been found to be forbidden due to deep influence on human physiology.

Aiming at musk. A significant proportion of patients are allergic to oral heterologous musks, inducing heart dysfunction, respiratory failure and visceral hemorrhage; the specific symptoms include nausea, vomiting, anorexia, hematemesis, hematochezia, odontoseisis, skin itching, erythema, pimple and the like. Such as oral and labial blushing, shortness of breath, headache, dizziness, shock, etc., in those suffering from severe allergic reactions.

The most prominent side effect of taking musk is internal hemorrhage; this is also one of the most significant toxic and side effects of Rhinoceros yellow pills.

It must be pointed out that the patients with weak constitution caused by tumors cannot take musk without thinking due to urgent psychology and no way of choosing; on the premise of taking the enteric protease pill to improve and ensure physique, musk is taken into consideration to prevent internal hemorrhage. Because musk belongs to an auxiliary agent in the luteolin pill, the luteolin pill has the effects of relieving pain and dredging collaterals and is mainly used for treating intra-abdominal accumulation and abdominal distention and pain; therefore, the method can be selectively applied and deleted according to the tumor part, constitution and self economic capability. And then according to the specific part of the pain, other original ecological genuine medicinal materials for relieving pain and dredging collaterals are used for replacing. For example, selecting rhizoma Ligustici Chuanxiong and fructus Lipuidambaris; radix Angelicae Dahuricae and herba Thymi; radix Curcumae and radix bupleuri; high content biochemical extract of Aspongopus and radix Clematidis.

The angelica dahurica has the effects of removing blood stasis, tonifying new blood, eliminating carbuncles and easing pain, and 30g of angelica dahurica can be singly used for replacing musk, so that the effect is also good. Especially, the aspongopus has remarkable effects of channeling, easing pain, warming middle-jiao and supporting yang, and also has the effects of sterilization and anti-tumor; it is also suitable for people with yang deficiency. Therefore, biochemical extracts of dahurian angelica root, aspongopus, thyme, clematis root and the like in the traditional Chinese medicinal materials are particularly preferred to replace musk as a medicament.

If the pain is severe and intolerable, the top-level external analgesic fentanyl plaster is directly used; the effect of the medicine is one thousand to ten thousand times of that of morphine injection, and the medicine has broad spectrum.

The musk is selectively used or the musk is used instead, so that the cost of medicinal materials can be greatly reduced in 83% of major proportion, and the luteolin pill similar to the 'medicated article' can be used by common people. Pain is not severe and can be tolerated. The extreme pain relieving medicines such as musk, fentanyl and the like are selected without great poisoning risk and high cost of medicinal materials.

The object is extremely necessary. The reverse thinking of national dialectical ideas is used for eliminating false passion of the rhinoceros yellow pills, and the main agent of the high-content compound bilirubin bezoar can also be used for racing with the time limited by the tumor in an amount of 0.5-1.0 times so as to quickly achieve the final purpose of shrinking tumor and eliminating tumor. Because of this, bilirubin, an endogenous strong antioxidant, is widely available in the biological world and is not subject to heterologous physiological rejection; this is also a true, cut, and blind positive solution.

Cancer cells are very different from normal cells, and have the characteristics of unlimited replication and proliferation, great transformation variation, nutrition and energy consumption and metastasis hazard. Effectively preventing the mistakes, proliferation and variation is the key to the response of cancer cell characteristics from the origin; bilirubin, an endogenous strong antioxidant, is precisely this property. Therefore, the combination and the covalent bilirubin with high content in the first-class bezoar are Qing Wang Hongxu and ancestor thereof, so as to obtain a key secret key for remarkable achievement; the medical proposal shown in the surgical syndrome treating all-living set has the effect which is like the magical assistance, and is not the hole wind; this is also a model of the natural phase, which takes on the life like a poor spirit.

For example, in daily cases of abnormal cell proliferation, increased bilirubin is found when biochemical tests are performed to detect liver function; abnormal cell dynamics are also perceived. According to the biochemical principle, the daily health care can actively and greatly reduce the error probability of normal cells or delay the variation and proliferation speed of the error cells by taking a little enteric-coated combination and covalent bilirubin at regular intervals so as to ensure the quality of life and prolong the service life; the chemical synthesis of modified seasonings is increased, so that active timing detoxification and removal are needed.

In japan, which is deeply subjected to the traditional Chinese cultural smoked pottery, bezoar has been widely used as a tonic since ancient times; is also one of the earliest and most deep countries for bezoar research.

When studying gout and uricase, people with high uric acid value have better probability of cell error and proliferation than those with lower uric acid value, and are not easy to cause diseases such as cancer and the like, such as cell error, weakness, mutation and the like; moreover, the face looks young and does not accord with the actual physiological age, and has the characteristics of firm muscle, fatigue resistance, high bone density, long working time, deep sleep, sharp thinking, strong memory, sensitive sensory response, flood and bright sound, strong penetrating power, long service life and the like; uric acid is also an endogenous strong antioxidant.

In the practice of gout and uricase, the polysaccharide organic molybdenum preparation is specially cultivated and extracted in fungi, and the increase of uric acid value is also rapidly promoted. This is a necessary consequence of the organo-molybdenum formulation strongly activating uric acid producing enzyme group activity in the liver; is also an active defending action.

Note that: for a detailed discussion of the principles of haematuria, see patent 201811098278.1, or 202210315756.X, filed by the present inventors.

This positive behavior can be maintained autonomously and replicated on bilirubin-increasing applications, especially 60 years after the age of entry; since bilirubin and hematuria are both endogenous strong antioxidants, it is only routine to monitor the hematuria with a household blood uric acid meter, optimally 400-450 umol/L (male) and 300-350 umol/L (female) that do not significantly exceed the saturation threshold. Thus, the side effect caused by physiological rejection of taking the heterologous medicine is avoided; but also fully develops the initiative of using the self oxidase group. The method is practical and has the advantages of high immunity, low cost, special effect, no toxic or side effect and strong persistence.

The invention discloses an rhinoceros yellow pill which is innovated by the inventor and also applies the two endogenous strong antioxidants of the human body; and the activity of the self antioxidant enzyme group is forcedly activated, so that high immunity is ensured, and the efficacy of the luteolin pill is greatly improved.

The combination class and the covalent bilirubin are studied for forty years, and no rapid and drastic side effect is found; therefore, the bezoar detoxification by using the endogenous strong antioxidant in large dose is proved to be the most key element of great success for the pioneering of Chinese medicine; in this regard, only 650 Chinese patent medicines of Chinese medicine type for clearing heat and detoxicating are prepared by using bezoar as the backbone of the Chinese hard mass.

Doubling time of intestinal cancer, liver cancer, gastric cancer, pancreatic cancer and esophageal cancer cells is 33 days on average; the doubling time of breast cancer cells was one week later, about 40 days. The more advanced this multiplication rate is, the faster it will develop; finally, the normal cells are rapidly extruded to occupy the existing space of the normal cells at the macroscopic punching speed so as to be suddenly swelled and expanded; pain and destruction of organ function then occur until the individual organs are not supplied with nutrition and the function is disabled and fatal.

Cancer cells are produced by errors in normal cellular metabolism. The error cell is physiologically perceived by people only when the variation of the error cell is proliferated to more than one billion; therefore, it is a matter of life and value to prevent the mistakes, variations and proliferation of cells during metabolism, namely bilirubin, uric acid, antioxidant enzyme group and leucocytes in the body.

To sum up. The applicability of musk, frankincense and myrrh which are biological medicines in the prescription of the rhinoceros Huang Wanzu is known, and the traditional Chinese medicine is greatly different from the western medicine; the medicine has no broad spectrum, and is characterized by uniqueness and uniqueness of the medicine due to diseases; the special style is revealed. Therefore, the preparation must be prepared and formulated according to the actual conditions of the individual patients; and the application mode and the application method can not treat hundreds of diseases by one party of the teaching strip, and one medicine is from ten thousands of families.

13. Freeness of millet and bilirubin

The action of millet in the formulation, most of the practised traditional Chinese medicine, only superficially maintains the stomach and prevents the medicine from irritating the gastric mucosa. The biochemical workers who know the property of bilirubin can go through the hole at a glance, and the real and real effect is caused by that the contained strong adhesive matters and gastric acid do not react rapidly; that is, bound bilirubin tightly packed with a strong adhesive substance cannot be easily released in a large amount in a short time, and reacts with gastric acid to produce a large amount of free bilirubin, resulting in irreversible neurotoxic cachexia. Thus, millet is a great wisdom that the person inventing the luteolin pill is deliberately fooled into; this was an unexpected advanced pharmaceutical technology three hundred years ago.

The invention is ingenious in year-round practice and demonstration, and also presents advanced methods of three hundred years of forefront Wang Hongxu and ancestor thereof for identifying pharmacology, distinguishing medicine properties and skillful preparation; the function of the corn zein-containing coating material is the same principle as that of corn zein which is found and widely applied three hundred years later.

The method also creates a real problem, and if the enteric material is used for isolation protection in the preparation of the rhinoceros Huang Wanshi, the worry of injuring the stomach is easily relieved; the millet with low content of enteric matters and low purity can be deleted, and the quality of the combined bilirubin in the bezoar is tightly protected from being changed at all by a plurality of high-purity enteric materials, so that the bezoar has maximum efficacy and plays a role in wonder; completely avoids irreversible damage to the nervous system caused by large doses of free bilirubin.

More significantly, bilirubin is a highly potent photosensitizer and endogenous strong antioxidant; when making pill, if it is wet, light and oxygen for a long time, it is converted into a great amount of bilirubin isomers such as biliverdin, etc., which deeply affect liver function. Aiming at the characteristic defect of bezoar, the enteric material can effectively avoid; and greatly shortens the time required for preparing pills, shortens the contact time of bilirubin with water, light and oxygen as much as possible, and reduces the loss of running, overflowing, leaking and dripping in the working procedure. In a word, the application of the enteric material ensures the drug effect; but also improves the work efficiency, has hundred benefits without harmful effects.

14. Modern dry and Qing dynasty wet millet coating and composite coating pelleting process test effect comparison:

(1) According to the prescription of the Chinese and western yellow pill in Chinese pharmacopoeia, the dosage is reduced in equal proportion, and simulated gastric juice is added; the freeness was measured based on the shortest retention time of the aqueous solution in the stomach of 5min on an empty stomach:

(1) taking 236mg of steamed and dried millet powder, uniformly mixing with 372mg of vinegar-processed frankincense and 372mg of vinegar-processed myrrh fine powder, adding 10mg of bezoar and 10mg of musk fine powder, uniformly mixing, preparing into pills by water drops, and carrying out vacuum drying to obtain 1g of Xihuang pills.

(2) Adding 1g of Xihuang pill into a test tube, adding 5ml of purified water, adding 50ul of hydrochloric acid to simulate gastric juice, carrying out ultrasonic mixing for 1min, adding into a constant-temperature water bath at 37 ℃ for 1min, centrifuging at a low speed for 1min, pumping 5ml of upper liquid into another test tube, adding 5ml of chloroform, sealing, placing a vortex for mixing for 1min, standing in the constant-temperature water bath for 1min, pumping lower chloroform into a cuvette by a needle filter, and measuring absorbance at 453nm wavelength to obtain 1.47.

(2) According to the prescription of the Rhinoceros yellow pill in Qing & Zhu Quansheng Ji (surgical syndrome treating total life) in equal proportion, the dosage is reduced, and simulated gastric juice is added, and the freeness is measured based on the minimum retention time of water in stomach in empty stomach of 5 min:

(1) 314.4mg of frankincense and myrrh powder prepared from rush core, 47.2mg of musk and 9.4mg of 'rhinoceros bezoar' containing 65% bilirubin are ground into fine powder for later use; grinding 314.4mg of yellow rice into fine paste, adding the fine powder for later use, mixing with the fine paste, deeply grinding, preparing pills with the size of 2-3 mm, and vacuum drying to obtain 1g of rhinoceros yellow pills.

(2) Adding 1g of rhinoceros yellow pill into a test tube, adding 5ml of purified water, adding 50ul of hydrochloric acid to simulate gastric juice, carrying out ultrasonic mixing for 1min, adding into a constant-temperature water bath at 37 ℃ for 1min, centrifuging at a low speed for 1min, pumping 5ml of upper liquid into another test tube, adding 5ml of chloroform, sealing, placing a vortex for mixing for 1min, standing in the constant-temperature water bath for 1min, pumping lower layer of chloroform into a cuvette by a needle filter, and measuring absorbance at 453nm wavelength to obtain 1.2.

(3) The enteric-coated luteolin pill is prepared according to the compound coating pill preparation process of the patent. That is, a portion of the prescription is first dosed; if the extract is used, the micro-wave prepared frankincense, myrrh and the substitute musk extract are mixed and made into enteric micropill; then together with enteric pellets and microparticles of bilirubin 'Rhinoceros bezoar', the bilirubin 'Rhinoceros bezoar' with the bilirubin content of 65% are prepared into enteric pellets, and double enteric protection Rhinoceros yellow pellets are formed. The principle and the purpose are as follows: enteric-coated pills in two forms of pills and micropills form a time difference when dissolved and released in intestinal tracts; that is, the large enteric-coated luteolin pill is firstly contacted with intestinal juice, so that the 'luteolin' particles in the pill are firstly dissolved and released by the enteric-coated micropill in the pill, and are digested and absorbed by the previous section of intestinal tract; the enteric pellets are dissolved and released after being digested and absorbed by the later intestinal tract. The two pills are not released in the same intestinal tract at the same time and meet each other, so that the mutual combination interference in the local area is not formed.

(1) 10mg of compound bilirubin powder with the bilirubin content of 65% is extruded into particles by a die with the aperture of 0.5mm for standby; taking 628.8mg of frankincense and myrrh which volatilize free acid by microwaves, adding 47.2mg of a substitute musk extract, adding 171.5mg of zein, uniformly mixing, extruding into particles by a die with the aperture of 0.5mm, adding 142.5mg of ethanol solution of the zein for coating, and vacuum drying to obtain 1g of enteric-coated pellets; mixing with bilirubin content 65% of composite bilirubin 'Rhinoceros bezoar' particles, making into 6-8 mm diameter bare pill, and coating enteric film to obtain enteric-coated Rhinoceros yellow pill.

(2) Adding 1g of enteric-coated luteolin pill into a test tube, adding 5ml of distilled water, adding 50ul of hydrochloric acid to simulate gastric juice, mixing uniformly by ultrasound for 1min, putting into a constant-temperature water bath kettle at 37 ℃ for 1min, and taking out until the morphology of the enteric-coated luteolin pill is complete as before; carefully observing without damage, adding 5ml of chloroform, sealing, uniformly mixing for 1min by a vortex device, standing for 2min in a constant-temperature water bath, pumping the lower layer of chloroform into a cuvette by a needle filter, and measuring absorbance at 453nm wavelength to obtain 0.05.

(4) Conclusion: whether the yellow rice is used as the enteric coating by the modern dry method and the Qing dynasty wet method, the freeness of the yellow rice in simulated gastric fluid in 5 minutes exceeds the legal definition that the freeness of bezoar is not more than 0.7 in Chinese pharmacopoeia; that is, millet cannot meet the requirements of toxicity of bezoar in the modern medicine toxicology sense.

The comparison result of the dissociation test of the product in simulated gastric acid proves that the enteric-coated luteolin pill is more suitable for perfect requirements on the toxicity of bezoar and effectively improves the efficacy of the luteolin pill; it is virtually impossible to ensure full-scale equivalent release of the potency of binding bilirubin.

15. Devil's fruit produced by bilirubin photosensitivity

Bilirubin is a highly effective photosensitizer, and is prone to produce isomers under light, water and oxygen; the bezoar contains the naturally occurring quantitative biliverdin, is a biochemical medicament for treating liver, and is also an important biochemical pharmaceutical raw material for treating hepatitis, liver cirrhosis and liver cancer; however, the liver was too much and was not retrophagic. Also because of this, special attention must be paid to the color of the bezoar when it is obtained; those with other colors such as green, black and red are removed uniformly, which is not adopted.

Assaying three key indexes of bezoar; that is, bilirubin has a freeness of 0.3-0.7, is too low to be useful, and is too high to be useful; the higher the bilirubin content is, the better, and the bilirubin content reaches more than 65% and is the first-class quality; the total cholic acid content is between 4% and 6%, and too low is false and too high is not usable. If the three values are repeatedly detected, the values cannot drift greatly, and the method belongs to a normal qualified product in scientific quantitative values. In the extreme case, the physiological natural proportion relationship between ten cholic acids in total cholic acids should be detected to determine the grade, value and authenticity of calculus bovis.

According to practical experience, the visual of the bezoar is that in normal color, other colors except dark red, dark orange, tan, brown yellow and turquoise are excluded; because fake, counterfeit, fake and inferior bezoar are already flooded in the traditional Chinese medicine market to be disaster, the true bezoar is rare and precious since ancient times, and can be obtained occasionally, so that the bezoar is extremely fortune; therefore, there is a history of "one-two bezoar-two-gold".

According to the national Chinese medicine information. Under the natural state, the annual bezoar production is less than one ton in China. The twenty years ago, the supply and demand contradiction is solved by the import supply worldwide, but since 2000, the nations have issued urgent orders for forbidding import due to the occurrence of overseas mad cow disease, and the urgent orders are not released yet. Therefore, the circulation possession of bezoar in the domestic traditional Chinese medicine market is what is precious and scarce, and bezoar in the first class is rare. Therefore, the safest method for obtaining the bezoar is tested by the national food and drug administration for three key indexes of bezoar, and is only a safe guarantee. This is a legal test, and many of the intrinsic tests for calculus bovis quality exist at various biochemical laboratories and laboratory researchers, and have not been disclosed in the context of legal tests; common lovers have difficulty in cognition and imitation.

For example, bezoar contains six bilirubins; one of the agents is covalent bilirubin, has extremely special property, is not afraid of strong acid and strong alkali, has extremely stable texture and high biological activity, is a special stabilizer for bezoar, and is used for maintaining the bezoar for decades without producing bad fruits with increased bilirubin freeness; is also a biochemical drug which is very good for the liver.

16. Preparation of Rhinoceros yellow pill

Preparation method and administration method of Rhinoceros yellow pill in Qing & Zhu Zheng Zhi Quansheng Ji (surgical syndrome treating and total life collection): the Chinese medicinal composition is prepared by grinding Olibanum and Myrrha into powder, mixing Moschus and calculus bovis into three parts, grinding together, mixing with millet and rice, grinding into powder, making into pill such as semen Raphani, sun-drying, and preventing baking. The wine is taken after the wine is aged, and the drunk cover takes the Chinese medicine every time three times of taking. For those with mammary gland, or with the symptoms of awaking, or with the symptoms of excessive eruption, or with the symptoms of fluid flow, pulmonary abscess, or acute appendicitis, the medicated wine is administered after every three times. The upper part of the patient is the next-to-lying clothes, and the lower part is the hollow clothes.

Note (1): the inventor works in woody, suzhou, ancestor of the 'Rhinoceros yellow pill' inventor, and eyes see that a local practitioner 'shines' the 'fine materials' Chinese medicinal materials, which are covered by reed mats, but not directly exposed to sunlight; only the discoloration and denaturation of the medicinal materials are prevented according to the knowledge obtained at the time.

Note (2): judging whether the patient is 'yin-syndrome yang deficiency' by the first ancestor of Qing dynasty Wang Hongxu and the ancestor of Qing dynasty, and judging whether the skin color of the tumor swelling part is reddish or not; if the skin color is normal, the skin color is not reddened, and is the yang deficiency phase.

Note (3): the yang deficiency phase is characterized by pale or dull complexion; sweating due to deficiency in the daytime; aversion to cold, cold limbs; clear and long urine; a pale tongue coating; the pulse is deep, thready and weak; weak breath, shortness of breath, debilitation, low voice; abdominal pain prefers to press; reduced diet; the mouth is light and tasteless; not restless and thirst.

Disclosure of Invention

The invention provides a luteolin pill.

The technical problem to be solved by the invention is to provide an enteric-coated luteolin pill with broad spectrum, low cost and no toxic or harmful property. The preparation of the luteolin pill is in compliance with the principle of pharmacology and preparation obtained from three hundred years. According to the content of the first-class bezoar bilirubin, the compound bilirubin with the bilirubin content of more than 65% can be used for forming industrialized production scale; otherwise, the luteolin pill can only be the epiphyllum of 'ancestral' in the biochemical laboratory, and becomes an ornamental product of 'medical science case' in high-end people. Also, enteric-coated luteolin pellets must ensure bilirubin levels of up to 6mg or more per 1 g; once a day, 11.2g of the Chinese herbal medicine can be used for reproducing the wonderful nature and efficacy of the Chinese herbal medicine; this is also a key to demonstrate mediocre and profound performance.

1. The mg amount of bilirubin in per 1g of enteric luteolin bolus is calculated:

if the compound bilirubin with the bilirubin content of 65% is 1.12g, then: 1.12g×65% = 0.728g×1000 mg=728 mg/118.62 g=6.14 mg/g;

2. comparison of bilirubin content per 1g of enteric-coated luteolin pill and Xihuang pill: 6.14 ≡1.9=3.23 times. A number of 3.23 times, also widely proven; in high-end people, when bezoar is used as a medicine, the effect of eliminating tumor with a surging tongue can be felt only by expanding the Xihuang pill to 3-4 times of dosage without taking serious consequences of various toxicity peculiar to bezoar; that is, the extraordinary efficacy of preparing the luteolin pill by using the 'calculus bovis' can be demonstrated.

3. The dosage of the ancient prescription is calculated: "three money per meal" =11.19 g;

4. the times of taking the paleo-formula are calculated: 118.62 g/11.19 g/day = 10.6 times;

5. the daily dosage is calculated: 118.62 g/10.6 times = 11.2g;

6. calculating the number of the pills prepared by the daily dosage: 11.2 g/0.5 g/pellet = 22.4 pellets;

7. the administration method comprises the following steps: because the enteric-coated luteolin pill has low content of free bilirubin and high efficacy compared with the luteolin pill of the ancient method after being taken into the stomach, the enteric-coated luteolin pill can be taken twice a day and three times a day, and in a fasting state, the enteric-coated luteolin pill is taken for 5 to 15 days with hot low alcohol, hot fermented glutinous rice soup and hot ginger soup; 8-16 grains each time; if the patients feel uncomfortable and cannot bear the disease, the patients gradually decrease and even stop taking the medicine. After the discomfort is over, the medicine is taken continuously; after the tumor is reduced and disappeared, the medicine is taken in gradually decreasing health care amount every 1 day, 2 days, 3 days, 5 days and 7 days, so as to maintain the state of clinical cure.

8. Preparing biochemical extract for replacing musk: 30g of angelica dahurica, 30g of thyme, 20g of aspongopus and 20g of radix clematidis, crushing, extracting components dissolved in alcohol by ethanol reflux, and separating out an upper alcohol solution for later use; squeezing the lower layer residue, mixing the squeezed solution with the alcohol solution for use, filtering with 100 mesh sieve, distilling the filtrate to recover alcohol, and collecting the bottom distillate for use; mixing the residue with the residue, reflux extracting with purified water to obtain water-soluble component, sieving with 100 mesh sieve, squeezing the residue, discarding, concentrating the filtrate with membrane, discarding the clear solution, mixing the concentrated solution with the alcohol-soluble component, and drying to obtain powder. The composition is also extracted by supercritical carbon dioxide, and has the advantages of higher yield, better quality and stronger effect.

9. Volatilizing light free acid in Olibanum and Myrrha, and making into enteric granule: pulverizing Olibanum and Myrrha 1:1 for short time, sieving with 50 mesh sieve, placing into glass basin of industrial microwave oven, and stirring and heating for 5 min; after discharging from the furnace, spreading out the volatilized light free acid in a stainless steel plate for 3-4 hours; repeating the above steps for 5 times, and decreasing the heating time for one minute each time to obtain Olibanum and Myrrha; taking 74.6g, adding 5.6g of the musk-replaced extract, adding 16.04g of zein, uniformly mixing, preparing particles with the size of 0.5-1.0 mm by a dry method, putting the particles into a film coating machine, and coating the particles with 3.76g of zein ethanol solution to obtain enteric particles with the total weight of 100 g.

10. Enteric-coated luteolin pill: 1.12g of compound bilirubin with the bilirubin content of more than 65 percent is added into 0.5-1.0 mm particles of a dry low-temperature granulating machine to be used as a agent a; 100g of enteric microparticles, which are agent b; uniformly mixing the agent a and the agent b in a mixer, and feeding the mixture into a pill making machine to obtain bare pills with the diameters of 7-8 mm; the bare pellets are put into a film coating machine and coated by 17.5g of enteric-coated materials, thus obtaining enteric-coated luteolin pellets, and the total weight is 118.62g.

11. Preparing enteric composite protease pills: firstly, adding trace metal elements such as polysaccharide organic molybdenum, germanium, zinc, selenium and the like extracted from fungus special culture and vitamin B6 into a mixer for uniform mixing, preparing particles with the diameter of 0.5-1.0 mm by a dry method, and adding the particles into a film coating machine to obtain enteric-coated particles of a critical enzyme activator which is agent a; mixing 200-260 uwan/g papain with unloaded body activity, 120-160 uwan/g bromelain with trehalose according to the proportion of 1:2:0.15, adding into a mixer for uniform mixing, granulating at low temperature by a dry method to obtain 0.5-1.0 mm particles as a preparation b; uniformly mixing the agent a and the agent b in a ratio of 1:200, and feeding into a pill making machine to obtain bare pills with diameters of 7-8 mm; the bare pill is put into a film coating machine to obtain enteric composite protease pills, which are called enteric protease pills for short; three times a day, and 1 to 15 grains of the Chinese medicinal composition are taken together with rice each time; after the physique is recovered, the medicine is taken in a health-care mode; the function of assisting the rapid metabolism of heterologous cells and ensuring the smooth intake of dietary nutrition and defecation; maintaining high levels of uric acid levels.

Of course, according to the pharmacology and experimental principles, the compound bilirubin, enteric particles and enteric protease can be independently filled into 3 enteric finished capsules for taking at staggered time; however, the individual enteric capsules have complicated administration procedures; and is very prone to panic individuals, some of which are abused by administration of large amounts of ingredients, such as bezoar or complex bilirubin.

12. Preparation of analgesic: preparing a fentanyl plaster if cancer pain is strongly intolerable; has the effect of strongly relieving pain for 72 hours.

13. Taking contraindications:

(1) Tea leaves and fermented seasonings are contraindicated; such as red fermented bean curd, fermented soybean paste, oyster sauce, fermented soybean, yogurt, and cheese; monosodium glutamate, chicken essence, artificial sweetener, flavoring agent, correctant, and flavoring agent, etc. Because tea water and fermented seasonings contain a large amount of digestive enzymes, simple substances and large amounts of amino acids and alkaloids, the enteric coating on the surface of the luteolin pill is easy to decompose in advance, so that the medicines are released in a large amount locally on the upper sections of the stomach and the intestinal tracts, and the gastric mucosa or the intestinal mucosa are strongly stimulated, and physiological reactions such as vomiting, abdominal pain and the like occur.

(2) The taste is light during the taking period, and the plant type high protein diet is needed; the conventional habitual meat is also suitable for eating, and the eating of the animal high-protein food is stopped with little discomfort.

(3) Fasting high-fat and high-cholesterol foods; such as yolk of eggs such as quail eggs, goose eggs, duck eggs and chicken eggs.

(4) Particularly fasting raw, cold and cool food; and fruit pears, watermelons, etc.

(5) Particularly forbids the low-temperature air conditioning environment and fans, and keeps the warm body temperature; in particular, the affected part should be kept warm at the periphery to maintain a temperature slightly higher than the body temperature.

(6) Pungent foods such as capsicum, garlic, mustard, leek, pepper, etc.; and extremely hot chocolate, coffee, chicken, duck, goose, fish, dog, cow, mutton; particularly, highly tonic aquatic products such as soft-shelled turtle, oyster, shrimp and crab are not suitable.

(7) Patients with hypotension, digestive system; for example, chronic enteritis, intestinal surgery is performed; for patients with internal hemorrhage and cancer, the Rhinoceros yellow pill should not be taken, and other formulations should be prepared separately except for the compound bilirubin.

(8) Is not suitable for being taken together with western medicines:

(1) sedative and anticonvulsant drugs are contraindicated to avoid central nervous depression;

(2) the administration of chloral hydrate, morphine and phenobarbital is contraindicated; because of the comatose, the respiratory center inhibition, the hypotension and the like which can cause acute poisoning;

(3) antagonizing epinephrine-like use is contraindicated;

(4) Atropine medicines are contraindicated.

(9) High tonic Chinese medicinal materials such as Ginseng radix, cornu Cervi Pantotrichum, and forest frog are contraindicated.

(10) Foods and drugs that promote sexual function are particularly contraindicated, such as:

(1) extracts of penis et testis bovis seu Bubali, testis Et penis Caprae seu Ovis, penis et testis Canitis, semen Allii Tuberosi, fructus Lycii, herba cistanches, radix Morindae officinalis, semen Cuscutae, gecko, and carapax Trionycis.

(2) The sildenafil class, tadalafil class chemical composition (Vigo); and herb-like epimedium herb, cabernet bark, etc.

(3) Flibanserin (sister peganum); female hormone-like flavone, flavonoid extract, contraceptive and artificially cultured finless eel; and, irritating perfumes and cosmetics.

(11) Sexual life is contraindicated during administration.

(12) The skin and lymph glands are conveniently and rapidly metabolized by hot water.

(13) No artificial chemical composition is taken in the period of taking medicine, so as to prevent extra metabolic burden on liver, intestinal tract and kidney and influence bilirubin metabolism; and, once the aura and phenomenon of blood pressure drop, heart rate slowing, respiratory and circulatory failure appear, the enteric luteolin pill is taken in a reduced amount; the patients with severe self-sensation immediately stop taking the medicine and drink warm purified water for rapid metabolism.

Although the Rhinoceros yellow pill has remarkable curative effect, the application time and the application method are also required; taking breast cancer as an example: qing dynasty Wang Hongxu and its ancestor are described in "Ruyanzhi" of surgical Zhi Ji quan Sheng Ji, "a small piece of milk is produced in the beginning, and this is manifested as a cold syndrome with phlegm, manifested as pain and itching, and the symptoms of awaking, and aversion to nuclei. The crying and worry are caused by the fear of the patient. At the beginning, the Rhinoceros yellow pill is taken for three times, and ten times of wine is taken for full healing. Or adding TUBEI WUJIN in YANG HE TANG, decocting for several days. the medicine is applied by the plaster for treating the pain of the internal organs due to the swelling gradually, and the pain is treated with late sense. , which is difficult to recover, is taken with yang and Shang Ri, or with Rhinoceros yellow pill daily, or with two medicines taken in the morning and evening. Six external large toads are taken from the beginning of the period of self-ulcer pain, and the toads are taken from the beginning of the period of daily for breaking abdominal and connecting impurities, the toads are pricked, stuck to the affected mouth and connected for three days. By taking Qianjin Torricelli powder, three days later, it can be saved by taking Xihuang Wan. The pain and itching after the ulcer are not relieved. The opening of the flower is forbidden, and the flower is most tragic, and the flower is free from liveness. This syndrome is common to both men and women.

Note that: the bolbostemma paniculatum is used for treating thyroid cancer, nasopharyngeal carcinoma, lung cancer, breast cancer, liver cancer, malignant lymphoma and the like, and can relieve cancer pain; the dosage is 10-30 g.

From the above, it is apparent that. When breast cancer is initially caused, the Qing dynasty Wang Hongxu is taken with yellow wine 11.2g and 118.62g of a pair of medicines every day, and the breast cancer is healed in ten days; if the yang and decoction are taken in turn, the bulbus fritillariae cirrhosae is added, the tumor is eliminated for 5-7 days. However, the patients suffering from the pain caused by the self-ulcer can take the luteolin pill after the plaster is externally applied by mistake, and the cure rate is only 30-40 percent; if the patient is not painful and itchy, no one is successful. "Daqiao" indicates "Wan Heng Ying" if "xi Huang Wan" is used after the operation. However, practical findings; the effect is also rapid for the radiation therapy patients. It has also been found that the operator has moved to delete the musk' of the channel dredging type, the frankincense and the myrrh in the prescription of the enteric-coated luteolin pill, and the combination type, the covalent bilirubin, the fentanyl plaster and the compound protease pill are singly used to promote the growth of another endogenous strong antioxidant-blood uric acid, and the synergistic combination type, the covalent bilirubin, the common tumor shrinking and eliminating effects are also achieved satisfactorily.

In practice, the enteric-coated luteolin pill is used in time in the initial occurrence period no matter what forms of tumors are deeply experienced, and success is easy to achieve. It is also inspired that the medicine is used for daily health care, reduces the error cell quantity during cell metabolism, delays the variation and proliferation of tumor cells, and is the most appropriate first choice for treating disease; as it was found to be most pertinent to human physiology so far; and is natural, effective, rapid, low in side effects, and capable of autonomous substances and methods. However, the highest success rate of tumor development reaches the middle stage and is only 50%. If the tumor is delayed to the later stage, the success rate reaches 10% though the special medical care is meticulous, which is all right; unfortunately, it is also very celebrating to alleviate pain and maintain much life time. Normally say: "medical non-death disease". For the diseases with extremely high mortality rate of cancers, the luteolin pill has the efficacy and is also praise.

Humans are an aggregate of extremely complex biochemical reactions. Is easily influenced by various subjective and objective things and factors. If the enteric-coated luteolin pill is used for more than 10 days, the enteric-coated luteolin pill still has no great efficacy; even if the indexes of acid glycoprotein such as CEA, CA19-9, CA72-4, CA50 and the like of the markers of the corresponding tumor are tested, the method of 'symptomatic' is needed to be searched without great reaction, and the extraordinary efficacy of the tumor can not be lost; otherwise, the patient may get into the outcome of "the patient is ill, and the patient is overrule.

When any therapy is ineffective, the patient cannot be fooled into the way of recalcitrant to black, and the illness state is delayed; the meditation thought and the demonstration of the meditation thought are also fooled to the utmost extent, and are completely trapped in the absolute situation; however, from everything about what is the drug? Spirit to what again? The method is as follows: "doctor gets illness, but doctor must not be enough. Although the efficacy of Rhinoceros yellow pill is different, it is never the best practice for treating all kinds of tumor, and it is still under investigation. In addition, the serious cautions are that the processing cost of the enteric-coated rhinoceros yellow pill Fei Jia percent is only 1/3 of the original ancient prescription value, and the enteric-coated rhinoceros yellow pill has broad spectrum; however, it is also necessary to take the medicine under the medical guidance of the medical practitioner. Tens of thousands of patients can not be privately prepared and taken in order to save the point diagnosis and treatment expense, and the devil fruits are caused to be lost in a small amount.

The beneficial effects of the invention are as follows: the defect, the spurious and the disadvantage of more than ten parts of the luteolin pill are found; such as rare rhinoceros yellow; expensive musk; vinegar-processed Olibanum and Vinegar-processed Myrrha which cause poisoning due to high bilirubin freeness in calculus bovis; free cholic acid content in low content bilirubin bezoar; millet with low content of enteric matters and low purity and short plates without broad spectrum; and, the uniqueness and uniqueness of the drug due to the disease are limited by the prescription of the drug. The invention picks up leakage and correction as much as possible, and gives the enteric-coated rhinoceros Huang Wanan spectrum, low cost and no toxicity by using biochemical extract, promoting hematouric acid and protease and enzyme activator. The ancient classical prescription similar to the 'magic article' becomes a affordable material and a health-care product for common people.

Detailed Description

The invention will be further illustrated with reference to examples.

Example 1 preparation of an alternative musk extract: 30g of angelica dahurica, 30g of thyme, 20g of aspongopus and 20g of radix clematidis, crushing, sieving with a 80-mesh sieve, reflux extracting components dissolved in alcohol with ethanol, and separating out an upper alcohol solution for later use; squeezing the lower layer residue, mixing the squeezed solution with the alcohol solution to be used, sieving with 100 mesh sieve, distilling the sieve solution to recover alcohol, and distilling the bottom component for use; mixing the residue with the squeezed residue, reflux extracting water-soluble component with purified water, sieving with 100 mesh sieve, squeezing the residue, discarding, concentrating the filtrate with membrane, discarding the clear solution, mixing the concentrated solution with the ethanol-soluble distilled component, and drying to obtain powder to obtain Moschus extract. The composition is also extracted by supercritical carbon dioxide, and has the advantages of higher yield, better quality and stronger effect.

Example 2 volatilization of light free acid: crushing raw frankincense and raw myrrh in a ratio of 1:1, sieving with a 50-mesh sieve, putting into a glass basin of an industrial microwave oven, stirring and heating for 5 minutes, discharging, and spreading volatile light free acid in a stainless steel plate for 3-4 hours; repeating the above steps for 5 times, and decreasing the heating time for one minute each time; the prepared frankincense and myrrh are obtained.

Example 3 preparation of enteric microparticles: taking 74.6g of olibanum and myrrh powder which volatilize light free acid, adding 5.6g of musk extract powder instead, adding 16.04g of zein, mixing uniformly in a mixer, preparing particles with the size of 0.5-1.0 mm by a dry method, putting the particles into a film coating machine, and coating the particles with 3.76g of zein ethanol solution to obtain enteric particles with the total weight of 100 g.

Example 4 enteric luteolin pellets were prepared: 1.12g of compound bilirubin with the bilirubin content of more than 65 percent is added into 0.5-1.0 mm particles of a dry low-temperature granulating machine to be used as a agent a; 100g of enteric microparticles, which are agent b; uniformly mixing the agent a and the agent b in a mixer, and feeding the mixture into a pill making machine to obtain bare pills with the diameters of 7-8 mm; the bare pills are put into a film coating machine and coated by 17.5g of enteric coating materials, thus obtaining 118.62g of enteric composite coated luteolin pills, which are abbreviated as enteric luteolin pills.

Example 5 enteric coated composite protease pellet: firstly, adding trace metal elements such as polysaccharide organic molybdenum, germanium, zinc, selenium and the like extracted from fungus special culture and vitamin B6 into a mixer for uniform mixing, preparing enzyme activator of particles with the diameter of 0.5-1.0 mm by a dry method, and adding the enzyme activator into a film coating machine to obtain enteric enzyme critical activator particles which are a agent; adding 200-260 uwan/g papain with unloaded body activity, 120-160 uwan/g bromelain with naked enzyme and trehalose into a mixer according to the proportion of 1:2:0.15, and uniformly mixing, and preparing particles with the particle size of 0.5-1.0 mm at low temperature by a dry method to obtain a preparation b; adding agent a and agent b into a mixer in a ratio of 1:200, mixing, and adding into a pill making machine to obtain bare pill; the bare pill is put into a film coating machine to obtain enteric composite coated composite protease pill, which is called enteric protease pill for short; three times a day, and 1 to 15 grains of the Chinese medicinal composition are taken together with rice each time; after physical recovery, the composition is taken for health care to maintain high level of uric acid level.

Example 6 according to the above pharmacological and experimental principles, the above compound bilirubin, enteric particles, enteric protease may also be independently filled into 3 enteric finished capsules, which are taken with staggered time; however, such separate administration forms are extremely prone to abuse of some of the formulations; such as complex bilirubin.

In the application, the theory and the process of the patent are continuously updated; the spurious results are also obtained by private use.

Claims

1. The rhinoceros-yellow pill is characterized by comprising two formulas A and B, a compound coating pill making process, a taking method and a taking tabu: the formula A and the composite coating pill preparation process are that composite bilirubin with the bilirubin content of more than 65 percent is prepared into particles with the particle size of 0.5-1.0 mm at low temperature by a dry method, and the particles are agent a; the enteric microparticles are agent b; mixing agent a and agent b in a mixer, and making into naked pill; the bare pills are put into a film coating machine to obtain enteric composite coated luteolin pills, which are called enteric luteolin pills for short; the formula B and the composite coating and pelleting process are that trace elements such as polysaccharide organic molybdenum, germanium, zinc, selenium and the like extracted from fungus special culture and vitamin B6 are put into a mixer to be mixed evenly, particles with the size of 0.5-1.0 mm are prepared by a dry method, and are put into a film coating machine to be coated, so as to obtain enteric enzyme critical activator particles which are a agent; then adding bare enzyme of papain and bromelain and trehalose into a mixer according to the proportion of 1:2:0.15, uniformly mixing, and preparing particles with the particle size of 0.5-1.0 mm at low temperature by a dry method to obtain a preparation b; adding agent a and agent b into a mixer in a ratio of 1:200, mixing, and adding into a pill making machine to obtain bare pill; coating the bare pellets in a film coating machine to obtain enteric coated composite protease pellets, namely enteric protease pellets; the compound bilirubin, enteric particles and enteric proteinase can be independently filled into 3 enteric finished capsules, and the capsules are taken in a staggered time section by section.

2. The composite coating process of claim 1, wherein a portion of the formulation is first prepared into particles and the enteric material is coated into enteric particles; then together with enteric particles and other particles of the rest of the formulation are made into pills and enteric coated, thus forming the pills with double enteric coating protection; the principle and the aim are that enteric coatings in two forms of pills and particles form a time difference when dissolved and released in intestinal tracts; that is, the pellets are firstly contacted with intestinal juice, so that the particles in the pellets are dissolved and released before the enteric particles are digested and absorbed by the previous section of intestinal tract; the enteric particles in the pill are dissolved and released after being digested and absorbed by the later intestinal tract; the two formulations are not released in the same intestinal tract at the same time and meet each other, so that the mutual chemical combination interference in the local area is not formed.

3. The enteric coated particles of claim 1, wherein 74.6g of olibanum and myrrh which volatilize light free acid are taken, 5.6g of musk extract is added, 16.04g of zein is added, the mixture is put into a mixer for uniform mixing, the particles with the size of 0.5-1.0 mm are prepared by dry method, and the particles are put into a film coating machine for coating by 3.76g of zein ethanol solution, thus obtaining the enteric coated particles with the total weight of 100 g.

4. The taking method as claimed in claim 1, wherein the enteric luteolin pill is taken with hot low alcohol wine, hot fermented glutinous rice soup and hot ginger soup three times per day in a fasting state for 5-15 days; 8-16 grains each time; if the patients feel uncomfortable during the taking, the grain number is gradually decreased, and even the patients are stopped taking for a plurality of days; after the discomfort is over, the medicine is taken continuously; after the tumor is reduced and disappears, the clinical cure state is maintained by gradually decreasing the health care dose of one pill every 1 day, 2 days, 3 days, 5 days and 7 days; the enteric protease pill is taken together with rice three times a day, 1-15 grains each time; after physical recovery, the composition is taken for health care to maintain high level of uric acid level.

5. Two enzymes in an enteric protease pellet as claimed in claim 1 characterized by a high activity naked enzyme not loaded with papain and bromelain.

6. The taking tabu of claim 1, characterized by (1) tabu tea leaves and fermented-like condiments; such as red fermented bean curd, fermented soybean paste, oyster sauce, fermented soybean, yogurt, and cheese; monosodium glutamate, chicken essence, artificial sweetener, flavoring agent, correctant, and flavoring agent, etc. Because tea water and fermented seasonings contain a large amount of digestive enzymes, simple substances and large amounts of amino acids and alkaloids, the enteric coating on the surface of the luteolin pill is easy to decompose in advance, so that the medicines are released in a large amount locally on the upper sections of the stomach and the intestinal tracts, and the gastric mucosa or the intestinal mucosa are strongly stimulated to generate physiological reactions such as vomiting, abdominal pain and the like;

(2) The taste is light during the taking period, and the plant type high protein diet is needed; the conventional habitual meat is also suitable for eating, and the eating of the animal high-protein food is stopped with little discomfort;

(3) Fasting high-fat and high-cholesterol foods; egg yolk of eggs such as quail eggs, goose eggs, duck eggs and chicken eggs;

(4) Particularly fasting raw, cold and cool food; and, fruit pears, watermelons, etc.;

(5) Particularly forbids the low-temperature air conditioning environment and fans, and keeps the warm body temperature; especially the affected part, the periphery is kept warm to maintain the temperature slightly higher than the body temperature;

(6) Pungent foods such as capsicum, garlic, mustard, leek, pepper, etc.; and extremely hot chocolate, coffee, chicken, duck, goose, fish, dog, cow, mutton; particularly, highly tonic aquatic products such as soft-shelled turtle, oyster, shrimp and crab are not suitable;

(7) Patients with hypotension, digestive system; for example, chronic enteritis, intestinal surgery is performed; patients with internal hemorrhage and cancer operation should not take the enteric-coated luteolin pill, and should keep other formulations except compound bilirubin;

(8) Is not suitable for being taken together with western medicines: (1) sedative and anticonvulsant drugs are contraindicated to avoid central nervous depression;

(2) the administration of chloral hydrate, morphine and phenobarbital is contraindicated; because of the comatose, the respiratory center inhibition, the hypotension and the like which can cause acute poisoning; (3) antagonizing epinephrine-like use is contraindicated; (4) atropine medicines are contraindicated;

(9) High-nourishing traditional Chinese medicines such as ginseng, antler, chinese forest frog oil and the like are forbidden to be eaten;

(10) Foods and drugs that promote sexual function are particularly contraindicated, such as: (1) extracts of penis Et testis bovis seu Bubali, testis Et penis Caprae seu Ovis, penis et testis Canitis, semen Allii Tuberosi, fructus Lycii, herba cistanches, radix Morindae officinalis, semen Cuscutae, gecko, and carapax Trionycis; (2) the sildenafil class, tadalafil class chemical composition (Vigo); and, herb epimedium herb, cabernet bark; (3) flibanserin (sister peganum); female hormone-like flavone, flavonoid extract, contraceptive and artificially cultured finless eel; and, irritating perfumes and cosmetics;

(11) Contraindicated in sexual life during administration;

(12) The hot water is used for bathing so as to facilitate and accelerate the metabolism of toxins in skin and lymph glands;

(13) No artificial chemical composition is taken in the period of taking medicine, so as to prevent extra metabolic burden on liver, intestinal tract and kidney and influence bilirubin metabolism; and, once the aura and phenomenon of blood pressure drop, heart rate slowing, respiratory and circulatory failure appear, the administration of luteolin pills is reduced; the patients with severe self-sensation immediately stop taking the medicine and drink warm purified water for rapid metabolism.

7. The substitute musk extract as set forth in claim 1, wherein the formulation and extraction method are: 30g of angelica dahurica, 30g of thyme, 20g of aspongopus and 20g of radix clematidis; pulverizing, sieving with 80 mesh sieve, reflux extracting alcohol-soluble component with ethanol, and separating upper alcohol solution; squeezing the lower layer residue, mixing the squeezed solution with the alcohol solution to be used, sieving with 100 mesh sieve, distilling the sieve solution to recover alcohol, and distilling the bottom component for use; mixing the residue with the squeezed residue, adding purified water, reflux extracting water-soluble component, sieving with 100 mesh sieve, squeezing the residue, discarding, concentrating the filtrate with membrane, discarding the clear liquid, mixing the concentrate with the alcohol-soluble distilled component, and drying to obtain powder to obtain Moschus extract; the composition is also extracted by supercritical carbon dioxide, and has the advantages of higher yield, better quality and stronger effect.