CN105709210A - Health food with liver protection function - Google Patents
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- CN105709210A CN105709210A CN201610068821.8A CN201610068821A CN105709210A CN 105709210 A CN105709210 A CN 105709210A CN 201610068821 A CN201610068821 A CN 201610068821A CN 105709210 A CN105709210 A CN 105709210A
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Abstract
The invention relates to a health food with a liver protection function, and belongs to the technical field of food processing. The health food is prepared from Chinese magnoliavine fruits, lucid ganoderma, moringa oleifera, maca, cervus elaphus linnaeus, cordyceps sinensis mycelium powder, concentrated whey protein, soybean protein isolate, VC, taurine, VB2, biotin, isomaltooligosacharide, lycopene and apple polyphenol. By carefully selecting raw materials and adopting a scientific composition, the health food has an auxiliary protection effect on the liver and also has the healthcare effects of preventing high blood pressure, high blood sugar and high blood lipid, resisting oxidation, delaying senescence, improving immunity and the like.
Description
Technical field
The present invention relates to a kind of health food with the liver protecting function, belong to food processing technology field.
Background technology
Long-term alcohol can raise the incidence rate of heart disease, hypertension, fatty liver, alcoholic cirrhosis and cerebrovascular significantly.Serious harm health.The harm of human body is mainly derived from excessive long-term alcohol and causes liver poisoning by ethanol.China is hepatopathy big country, and the hepatopathy such as viral hepatitis, fatty liver, alcoholic liver disease, medicamentous liver lesion and hepatocarcinoma has become one of principal disease of threatening human health in recent years.And owing to living habit and social custom problem cause some people's long-term alcohol even insobriety, ethanol has become the second largest killer of the liver being only second to viral hepatitis.In heavy drinker, more than 80% has a degree of fatty liver, and 10%～35% can develop into alcoholic hepatitis, and 10%～20% will develop into liver cirrhosis, and alcoholic cirrhosis prognosis is poor, and within 5 years, survival rate is about 23～50%.Investigation is pointed out, China's alcoholic liver disease ratio in all hepatopathys has increases trend year by year, but alcoholic liver disease there is no specific treatment medicine at present.
Summary of the invention
For solving above-mentioned technical problem, present invention aim at providing a kind of health food with the liver protecting function；This health food also has the health cares such as prevention " three high ", antioxidation, slow down aging, raising immunity.
Realize the object of the invention technical scheme as follows:
A kind of health food with the liver protecting function, its raw material includes Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus, Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, lycopene, apple polyphenol.
Preferably, described health food includes Fructus Schisandrae Chinensis 10-200 part, Ganoderma 10-200 part, Moringa 10-150 part, Maca 10-150 part, cervus elaphus linnaeus 5-50 part, Cordyceps mycelium powder 5-50 part, concentrated lactoalbumin 5-50 part, soybean protein isolate 5-50 part, VC0.0001-0.0005 part, taurine 0.0005-0.005 part, VB with its raw material of parts by weight20.0005-0.005 part, biotin 0.0005-0.005 part, dextrinosan 0.1-5 part, lycopene 0.01-0.1 part, apple polyphenol 0.01-0.1 part.
It is further preferred that described health food includes Fructus Schisandrae Chinensis 50-150 part, Ganoderma 50-150 part, Moringa 20-100 part, Maca 20-100 part, cervus elaphus linnaeus 10-40 part, Cordyceps mycelium powder 10-40 part, concentrated lactoalbumin 10-40 part, soybean protein isolate 10-40 part, VC0.0001-0.0005 part, taurine 0.001-0.005 part, VB with its raw material of parts by weight20.001-0.005 part, biotin 0.001-0.005 part, dextrinosan 1-5 part, lycopene 0.02-0.08 part, apple polyphenol 0.02-0.08 part.
It is preferred that described health food includes Fructus Schisandrae Chinensis 70 parts, Ganoderma 120 parts, Moringa 80 parts, Maca 35 parts, cervus elaphus linnaeus 15 parts, Cordyceps mycelium powder 20 parts, concentrated lactoalbumin 15 parts, soybean protein isolate 25 parts, VC0.0003 part, taurine 0.002 part, VB with its raw material of parts by weight20.003 part, biotin 0.002 part, dextrinosan 3 parts, lycopene 0.05 part, apple polyphenol 0.03 part.
In above-mentioned health food, it is preferable that Cordyceps polysaccharide content >=10% in described Cordyceps mycelium powder；Protein content in concentrated lactoalbumin is >=80% (with dry weight basis)；Protein content >=99% in soybean protein isolate；Content of lycopene >=10% in lycopene；Apple polyphenol content >=50% in apple polyphenol.
Described weight portion can be the unit of weights well known in the art such as μ g, mg, g, kg, it is also possible to is its multiple, such as 1/10,1/100,10 times, 100 times etc..
The above-mentioned health food with the liver protecting function, wherein Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus, Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, lycopene, apple polyphenol is as active raw materials.Preferably, its raw material of above-mentioned health food or adjuvant also include pharmaceutically or acceptable carrier on food or on health food.
Preferably, described health food is formed into oral formulations；Including: capsule, granule, tablet, packed medicinal tea, powder etc.；It is more preferably granule.
It is further preferred that its raw material of described health food or adjuvant also include microcrystalline Cellulose, magnesium stearate.
The preparation method that the present invention also provides for above-mentioned health food, the method comprises the following steps: weigh each composition according to proportioning, and mixing, conventionally formulation method prepares into preparation.
Preferably, the preparation method of above-mentioned health food comprises the following steps:
1) dispensing；Namely weigh needed raw material by proportioning and (include Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus, Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, lycopene, apple polyphenol etc.)；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, adding 50%-90% alcohol reflux 1-3 time of 5-10 times of weight, each 0.5-3.0 hour, filtration, filtering residue was standby；Merging filtrate, concentrates the filtrate to clear paste (relative density is 1.10-1.30,30 DEG C), adds ethanol and makes alcohol content reach 70%-75%, obtains solution I；
3) by step 2) gained filtering residue adds soak by water 1-3 time of 5-15 times of weight, and each 0.5-2 hour, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.10-1.30,30 DEG C), adding ethanol makes alcohol content reach 70%-75%, obtains solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10-1.30,30 DEG C)；All the other raw materials (Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB is added by formula2, biotin, dextrinosan, lycopene, apple polyphenol etc.) and appropriate amount of auxiliary materials make suitable dosage form.Preferably, add appropriate amount of auxiliary materials microcrystalline Cellulose, magnesium stearate, make granule.
Specifically, the preparation method of above-mentioned health food comprises the following steps:
1) dispensing；Namely weigh needed raw material by proportioning and (include Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus, Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, lycopene, apple polyphenol etc.)；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, with 70%-75% alcohol reflux 2 times, adding 8 times of w ethanol the 1st time and extract 3h, add 6 times of w ethanol the 2nd time and extract 1h, filter, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste (relative density is 1.10-1.30,30 DEG C), adds ethanol and makes alcohol content reach 70%-75%, obtains solution I；
3) by step 2) gained filtering residue boiling 2 times, add 10 times of weight water 1st time and decoct 2h, add 8 times of w ethanol 2nd time and extract 1h, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.10-1.30,30 DEG C), adding ethanol makes alcohol content reach 70%-75%, obtains solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10-1.30,30 DEG C)；All the other raw materials (Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB is added by formula2, biotin, dextrinosan, lycopene, apple polyphenol etc.) and appropriate amount of auxiliary materials make suitable dosage form.Preferably, add appropriate amount of auxiliary materials microcrystalline Cellulose, magnesium stearate, make granule.
If no special instructions, concentration of alcohol of the present invention refers both to volumetric concentration.
Experiment proves, the present invention adopts above-mentioned technique that traditional Chinese medicinal material raw materials is extracted, and at utmost remains the active ingredient of raw material of Chinese medicine, and the effective ingredient extracted is easiest to be absorbed by the body, strengthen the absorption of medicine, thus the problem avoiding invalid components interference drug effect.
Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandrachinensis (Turcz.) Baill. or schisandra chinensis SchisandrasphenantheraRehd.etWils., it is listed in the top grade Chinese medicine in Sheng Nong's herbal classic the earliest, the power of energy strengthening by means of tonics, medical value is high, has the effect of building body.Function cures mainly: astringe the lung, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, arresting seminal emission.Controlling the deficiency of the lung to breath with cough, xerostomia is made thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Trimethyl gallic acid salty enter liver and the kidney invigorating, pungent bitter in taste acting on the heart and tonifying the lung, sweet enter Middle Palace strengthening the spleen stomach.Impact on hepatic injury: schisandrol extract can reduce the laboratory animal glutamate pyruvate transaminase caused by carbon tetrachloride, thioethanolamine etc. and raise.Wuweizisu B (schisandrin B) has anti-liver injury effect.
Ganoderma property is put down, and bitter in the mouth is nontoxic, and master ties in the heart, the benefit motive, and invigorating middle warmer increases wisdom, do not forget, and clothes are made light of one's life by commiting suicide always for a long time, and prolong life angle.The hepatic injury that multiple physics and chemistry and biological factor are caused by Ganoderma has protective effect.No matter before liver injury occurs or after generation, take Ganoderma all can the liver protecting, alleviate hepatic injury.Ganoderma can promote the liver metabolism to medicine, poisonous substance, has definite curative effect for toxic hepatitis.Especially chronic hepatitis, Ganoderma can substantially eliminate the symptom such as dizziness, weak, nauseating, uncomfortable liver area, and can effectively improve liver function, makes indices tend to normal.Ganoderma can be used for treating chronic poisoning, all kinds of chronic hepatitis, liver cirrhosis, hepatic insufficiency.Ganoderma the kidney invigorating, benefit essence, dispel the wind；Immunologic function can be regulated, improve body major organ systems, such as the function of the heart, lung, liver, kidney etc..Research shows, Ganoderma can promote the nucleic acid of serum, liver and bone marrow and the biosynthesis of protein, has good the kidney invigorating effect.
Moringa (Moringa) is also known as drumstick tree (Drumsticktree), for Capparales Moringaceae, Moringa arbor.Moringa of the present invention is preferably moringa seeds, the i.e. seed of Moringa tree, it suffers from good using value in fields such as food, medicine, health care, cosmetics, because rich in seed oil of Moringa oleigera, it is reducing blood fat, blood pressure, and weight-reducing regulates the intestines and stomach, hepatoprotective alleviating alcohol addiction, strengthens body immunity aspect and all has significant curative effect.
Maca (formal name used at school: LepidiummeyeniiWalp), (Spanish: Maca).Mainly produce in South America Andes normal pulse Chinese yunnan Lijing, be a kind of crucifer.Due to nutrition containing multiple balanced and reasonable and multiple there is bioactive secondary metabolite in Maca, therefore, Maca possesses plurality kinds of health care and therapeutic efficiency and effect, can be used for strengthening energy traditionally, improve fertility, treat climacteric syndrome, rheumatism, depression, anemia, it addition, it also has the effects such as anticancer and leukemia.
Cervus elaphus linnaeus is the young horn of the unossified close raw fine hair of stag of animal in deer family Cervus nippon Temminck CervusnipponTemminck or Cervus elaphus linnaeus CervuselaphusLinnaeus.Nature and flavor with return through: sweet, salty, temperature.Return kidney, Liver Channel.Function with cure mainly: invigorating kidney-YANG, benefiting essence-blood, bone and muscle strengthening, adjust punching appoint, hold in the palm sore.For insufficiency of kidney-YANG, blood and essence asthenia, sexual impotence spermatorrhea, cold womb is infertile, wins thin, Mental fatigue, fear of cold, dizziness, tinnitus, and deaf, spinal column cold type of pain, muscles and bones flaccidity is soft, bleeding not during menses, and carbuncle of yin nature is not held back.
Cordyceps sweet in the mouth is warm in nature, and guarantor's lung kidney tonifying, tonifying deficiency, benefit marrow, hemostasis and phlegm, only consumptive disease are coughed.Cordyceps can alleviate chronic nephropathy, improves renal function, alleviates the toxicant infringement to kidney, has anti-renal failure effect.Cordyceps mycelium powder has similar composition and function to Cordyceps.Cordyceps mycelium powder of the present invention can be prepared by prior art, it is possible to commodity purchased product.Preferably, its strain of described Cordyceps mycelium powder is peacilomyce hepiahi PaecilomyceshepialiChenetDai, sp.nov or Hirsutella hepiali Chen et Shen HirsutellahepialiChenetShen.
Lycopene is a kind of natural pigment contained in plant.It is primarily present in the mature fruit of plant of Solanaceae Fructus Lycopersici esculenti.It is one of most powerful antioxidant of being found in the plant of nature at present.Science proves, singlet oxygen and oxygen-derived free radicals in human body are the arch-criminals encroaching on human body self immune system.Effect of lycopene scavenging free radicals outclass other carotenoid and vitamin E, and its singlet-oxygen quenching speed constant is 100 times of vitamin E.It can effectively preventing because of aging, the various diseases that immunity degradation causes.
Concentrated lactoalbumin of the present invention, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, lycopene, the equal buyable commercial prod of supplementary material such as apple polyphenol.
The present invention is with Chinese Traditional Medicine theory for instructing; in conjunction with modern medicine study routine; raw material is meticulously selected from health preserving angle; scientific composition; reach liver-protective health-care effect, also there is the health-care effects such as prevention " three high " (referring to hypertension, hyperglycemia (diabetes) and hyperlipemia), antioxidation, slow down aging, raising immunity.The present invention focuses on the overall conditioning of human body and inherent conditioning, and the healthy food products developed in conjunction with health preserving not only has liver-protective health-care effect, additionally it is possible to promote the good health and a long life of human body.The principles of formulating prescriptions of the present invention: with Fructus Schisandrae Chinensis, Ganoderma for monarch, with cervus elaphus linnaeus, Maca for minister, with Moringa, Cordyceps mycelium powder for assistant, with lycopene, apple polyphenol for making, coordinate concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, with collaborative raising product protection liver effect.All medicines share, and long memorial liver protects kidney, resolving depression pain relieving, effect of the liver protecting and ALT lowering QI and blood regulating altogether, and character of the present invention is peaceful, be beneficial to clothes of a specified duration, without adverse side effect.
Selected raw material of the present invention conditioning human five internal organs, comprehensive function reaches liver-protective health-care effect.Wherein making the motive vigorous by conditioning heart, painstaking effort fill；Liver storing blood, makes QI and blood gentle by nursing one's health liver, and blood operation is sufficient, gloss of having rosy cheeks；The spleen being the foundation of acquired constitution, source of generating QI and blood；Pass through function of spleen and stomach regulating so that it is the strong fortune of function, QI and blood is vigorous；Lung governing skin and hair, makes qi-blood-body fluid be able to spreading whole body by nursing one's health lung；Kidney controlling essence storage, by nursing one's health kidney, makes kidney essense fill, and when kidney qi is vigorous, function of five internal organs is also by properly functioning, and QI and blood is vigorous, and appearance does not wane.Health food of the present invention is a kind of to follow the fashion, take into account traditional product drink mode again, reaches to be of value to person in middle and old age and the purpose of sub-health population health care in satisfied.Health food action temperature of the present invention and, efficacy stability, have no side effect, be suitable for long-term drink.Research finds, long-term taking health food of the present invention also has the health-care effects such as prevention " three high ", antioxidation, slow down aging, raising immunity.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.Unreceipted concrete technology or condition person in embodiment, technology described by the document in this area or condition, or carry out according to product description.Agents useful for same or the unreceipted production firm person of instrument, be the conventional products can being commercially available by regular distributor.In following example and comparative example, Cordyceps mycelium powder is purchased from Hangzhou Zhong Gushannian Bioisystech Co., Ltd, and strain is peacilomyce hepiahi, wherein Cordyceps polysaccharide content >=10%；Concentrated lactoalbumin is purchased from inspiring confidence in (Tianjin) International Trading Company Ltd in pool, sky, and protein content is 80% (with dry weight basis)；Soybean protein isolate is purchased from Shandong YuWang Industry Co., Ltd, protein content >=99%；Lycopene is purchased from Rayleigh, Xi'an bio tech ltd, content of lycopene >=10%；Apple polyphenol is purchased from sky, Zhejiang grass biology company limited, apple polyphenol content >=50%.
Embodiment 1
A kind of health food with the liver protecting function, includes Fructus Schisandrae Chinensis 200 parts, Ganoderma 200 parts, Moringa 150 parts, Maca 150 parts, cervus elaphus linnaeus 50 parts, Cordyceps mycelium powder 50 parts, concentrated lactoalbumin 50 parts, soybean protein isolate 5-50 part, VC0.0001-0.0005 part, taurine 0.0005-0.005 part, VB with its raw material of parts by weight20.0005-0.005 part, biotin 0.0005-0.005 part, dextrinosan 0.1-5 part, lycopene 0.01-0.1 part, apple polyphenol 0.01-0.1 part.
Embodiment 2
A kind of health food with the liver protecting function, includes Fructus Schisandrae Chinensis 10 parts, Ganoderma 10 parts, Moringa 10 parts, Maca 10 parts, cervus elaphus linnaeus 5 parts, Cordyceps mycelium powder 5 parts, concentrated lactoalbumin 5 parts, soybean protein isolate 5 parts, VC0.0001 part, taurine 0.0005 part, VB with its raw material of parts by weight20.0005 part, biotin 0.0005 part, dextrinosan 0.1 part, lycopene 0.01, apple polyphenol 0.01 part.
Embodiment 3
A kind of health food with the liver protecting function, includes Fructus Schisandrae Chinensis 50 parts, Ganoderma 50 parts, Moringa 20 parts, Maca 20 parts, cervus elaphus linnaeus 10 parts, Cordyceps mycelium powder 10 parts, concentrated lactoalbumin 10 parts, soybean protein isolate 10 parts, VC0.0001 part, taurine 0.001 part, VB with its raw material of parts by weight20.001 part, biotin 0.001 part, dextrinosan 1 part, lycopene 0.02 part, apple polyphenol 0.02 part.
Embodiment 4
A kind of health food with the liver protecting function, includes Fructus Schisandrae Chinensis 150 parts, Ganoderma 150 parts, Moringa 100 parts, Maca 100 parts, cervus elaphus linnaeus 40 parts, Cordyceps mycelium powder 40 parts, concentrated lactoalbumin 40 parts, soybean protein isolate 40 parts, VC0.0005 part, taurine .005 part, VB with its raw material of parts by weight20.005 part, biotin 0.005 part, dextrinosan 5 parts, lycopene 0.08 part, apple polyphenol 0.08 part.
Embodiment 5
A kind of health food with the liver protecting function, includes Fructus Schisandrae Chinensis 70 parts, Ganoderma 120 parts, Moringa 80 parts, Maca 35 parts, cervus elaphus linnaeus 15 parts, Cordyceps mycelium powder 20 parts, concentrated lactoalbumin 15 parts, soybean protein isolate 25 parts, VC0.0003 part, taurine 0.002 part, VB with its raw material of parts by weight20.003 part, biotin 0.002 part, dextrinosan 3 parts, lycopene 0.05 part, apple polyphenol 0.03 part.
Embodiment 6
A kind of health food with the liver protecting function, includes Fructus Schisandrae Chinensis 80 parts, Ganoderma 100 parts, Moringa 60 parts, Maca 55 parts, cervus elaphus linnaeus 18 parts, Cordyceps mycelium powder 25 parts, concentrated lactoalbumin 25 parts, soybean protein isolate 15 parts, VC0.0002 part, taurine 0.003 part, VB with its raw material of parts by weight20.002 part, biotin 0.003 part, dextrinosan 2 parts, lycopene 0.03 part, apple polyphenol 0.05 part.
Embodiment 7
A kind of health food with the liver protecting function, its formula is identical with embodiment 1, and the preparation method of this health food comprises the following steps:
1) dispensing；Namely needed raw material is weighed by proportioning；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, adding 90% alcohol reflux 3 times of 5 times of weight, each 0.5 hour, filter, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste (relative density is 1.30,30 DEG C), adds ethanol and makes alcohol content reach 75%, obtains solution I；
3) by step 2) gained filtering residue adds the soak by water 3 times of 5 times of weight, and each 0.5 hour, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.30,30 DEG C), add ethanol and make alcohol content reach 75%, obtain solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.30,30 DEG C)；All the other raw materials (Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB is added by formula2, biotin, dextrinosan, lycopene, apple polyphenol etc.) prepare active mixture；Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag；Suggestion eating method and amount: every day 3 times, each 1 bag, warm boiled water；24 months shelf-lifves；Storage practice room temperature, ventilation, dry place.
Embodiment 8
A kind of health food with the liver protecting function, its formula is identical with embodiment 2, and the preparation method of this health food comprises the following steps:
1) dispensing；Namely needed raw material is weighed by proportioning；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, adding 50% alcohol reflux 1 time of 10 times of weight, each 3.0 hours, filter, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste (relative density is 1.10,30 DEG C), adds ethanol and makes alcohol content reach 70%, obtains solution I；
3) by step 2) gained filtering residue adds the soak by water 1 time of 15 times of weight, and each 2 hours, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.10,30 DEG C), add ethanol and make alcohol content reach 70%, obtain solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10,30 DEG C)；All the other raw materials (Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB is added by formula2, biotin, dextrinosan, lycopene, apple polyphenol etc.), prepare active mixture；Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag；Suggestion eating method and amount: every day 3 times, each 1 bag, warm boiled water；24 months shelf-lifves；Storage practice room temperature, ventilation, dry place.
Embodiment 9
A kind of health food with the liver protecting function, its formula is identical with embodiment 3, and the preparation method of this health food comprises the following steps:
1) dispensing；Namely needed raw material is weighed by proportioning；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, with 70% alcohol reflux 2 times, adding 8 times of w ethanol the 1st time and extract 3h, add 6 times of w ethanol for the 2nd time and extract 1h, filtration, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste (relative density is 1.10,30 DEG C), adds ethanol and makes alcohol content reach 70%, obtains solution I；
3) by step 2) gained filtering residue boiling 2 times, add 10 times of weight water 1st time and decoct 2h, add 8 times of w ethanol 2nd time and extract 1h, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.10,30 DEG C), adding ethanol makes alcohol content reach 70%, obtains solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.10,30 DEG C)；All the other raw materials (Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB is added by formula2, biotin, dextrinosan, lycopene, apple polyphenol etc.), prepare active mixture；Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag；Suggestion eating method and amount: every day 3 times, each 1 bag, warm boiled water；24 months shelf-lifves；Storage practice room temperature, ventilation, dry place.
Embodiment 10
A kind of health food with the liver protecting function, its formula is identical with embodiment 5, and the preparation method of this health food comprises the following steps:
1) dispensing；Namely needed raw material is weighed by proportioning；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, with 75% alcohol reflux 2 times, adding 8 times of w ethanol the 1st time and extract 3h, add 6 times of w ethanol for the 2nd time and extract 1h, filtration, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste (relative density is 1.30,30 DEG C), adds ethanol and makes alcohol content reach 75%, obtains solution I；
3) by step 2) gained filtering residue boiling 2 times, add 10 times of weight water 1st time and decoct 2h, add 8 times of w ethanol 2nd time and extract 1h, collecting decoction, filter, concentrate the filtrate to clear paste (relative density is 1.30,30 DEG C), adding ethanol makes alcohol content reach 75%, obtains solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste (relative density is 1.30,30 DEG C)；All the other raw materials (Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB is added by formula2, biotin, dextrinosan, lycopene, apple polyphenol etc.), prepare active mixture；Taking this active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Product specification 20g/ bag；Suggestion eating method and amount: every day 3 times, each 1 bag, warm boiled water；24 months shelf-lifves；Storage practice room temperature, ventilation, dry place.
Embodiment 11
A kind of health food with the liver protecting function, its formula is identical with embodiment 4, and the preparation method of this health food is with embodiment 9.
Product specification 20g/ bag；Suggestion eating method and amount: every day 3 times, each 1 bag, warm boiled water；24 months shelf-lifves；Storage practice room temperature, ventilation, dry place.
Embodiment 12
A kind of health food with the liver protecting function, its formula is identical with embodiment 6, for the packed medicinal tea made according to a conventional method.
Embodiment 13
A kind of health food with the liver protecting function, its formula is identical with embodiment 2, for the capsule made according to a conventional method.
Embodiment 14
A kind of health food with the liver protecting function, its formula is identical with embodiment 3, and its preparation method includes first making prepared active mixture by the method for embodiment 8；Conventional method makes tablet again.
Embodiment 15
A kind of health food with the liver protecting function, its formula is identical with embodiment 4, and its preparation method includes first making prepared active mixture by the method for embodiment 9；Conventional method makes capsule again.
Embodiment 16
A kind of health food with the liver protecting function, its formula is identical with embodiment 5, and its preparation method includes first making prepared active mixture by the method for embodiment 8；Conventional method makes tablet again.
Comparative example 1
A kind of Chinese medicine granules, only includes Fructus Schisandrae Chinensis 15 parts, Ganoderma 120 parts, Maca 35 parts with its raw material of parts by weight；Its preparation method includes first by the method for embodiment 10, Fructus Schisandrae Chinensis, Ganoderma, Moringa being prepared clear paste (i.e. step 4) clear paste, and relative density is 1.30,30 DEG C)；Taking this clear paste 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Comparative example 2
A kind of Chinese medicine granules, only includes Moringa 80 parts, cervus elaphus linnaeus 70 parts, Cordyceps mycelium powder 20 parts, concentrated lactoalbumin 15 parts, soybean protein isolate 25 parts with its raw material of parts by weight；Its preparation method includes first by the method for embodiment 10, Maca, cervus elaphus linnaeus being prepared clear paste (i.e. step 4) clear paste, and relative density is 1.30,30 DEG C)；Press formula again and add Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, prepare active mixture；Taking active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Comparative example 3
A kind of Chinese medicine granules, includes Cordyceps mycelium powder 20 parts, concentrated lactoalbumin 15 parts, soybean protein isolate 25 parts, dextrinosan 3 parts, lycopene 0.05 part, apple polyphenol 0.03 part with its raw material of parts by weight.Its preparation method includes first by Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, dextrinosan, lycopene, apple polyphenol mix homogeneously, prepares active mixture；Taking active mixture 100 parts, add maltodextrin 12.5 parts, microcrystalline Cellulose 55.5 parts, mix homogeneously, add ethanol in proper amount solution soft material, 16 mesh sieves are granulated, and 60 DEG C dry, 12 mesh sieve granulate and granules.
Chemical liver injury is had auxiliary protection function zoopery by experimental example 1
Experimental technique: according in " health food inspection and assessment technique specification-2003 ", chemical injury is had auxiliary protection function test method, adopt alcoholic hepatic injury model scheme.Laboratory sample: the health food granule of embodiment 10 preparation, Chinese medicine granules prepared by control sample: comparative example 1-3.Laboratory sample and control sample are pressed human body respectively recommends consumption for everyone (adult) every day 3 times, and each 20g is converted to 1g/kg BW by 60kg body weight.Separately set an alcoholic hepatic injury model group (model control group) and a negative control group.Often 12 animals (male white rat) of group.
Experimental result:
1. the sample impact on rat body weight: before test, each group rat body weight is consistent, the gain in weight when body weight of each all rats of process of the test and off-test compares mutually, difference does not all have significance (P > 0.05), it was shown that the body weight of rat is increased satisfaction and significantly affects effect by this sample.
2. the sample impact on hepatic tissue lipid peroxidation catabolite malonaldehyde (MDA) content of alcoholic liver injury in rats: the Liver MDA of liver injury model control rats is aobvious higher than negative control group, and both difference has pole significance (P < 0.01), illustrate that liver injury model is set up.Matched group (control sample 1-3, down together) Liver MDA of rat is below liver injury model matched group, but there are no significant (P > 0.05) for the difference of each group and liver injury model matched group, show that the LPO in the liver tissues of rats that Alcoholic is damaged by this sample has certain reduction effect, but be not as obvious.Experimental group (the health food granule of embodiment 10 preparation, down together) Liver MDA of rat is substantially less than liver injury model matched group (P < 0.05), it was shown that the LPO in the liver tissues of rats that Alcoholic is damaged by this sample has the effect of significantly reducing.
The impact on hepatic tissue triglyceride (TG) content of alcoholic hepatic injury rat of 3 samples:
The hepatic tissue TG content of liver injury model control rats is apparently higher than negative control, and both difference has pole significance (P < 0.01), illustrates that hepatic injury is substantially set up.The hepatic tissue TG content of matched group 1-3 rat is below liver injury model matched group, but there are no significant (P > 0.05) for the difference of each group and liver injury model matched group, show that the LPO in the liver tissues of rats that Alcoholic is damaged by this sample has certain reduction effect, but be not as obvious.The hepatic tissue TG content of experimental group rat is substantially less than liver injury model matched group, difference is respectively provided with pole significance (P < 0.01), illustrates that this sample has the effect of hepatic tissue triglyceride (TG) content of the rat reducing Alcoholic damage.
The impact on hepatic tissue Reductive glutathione (GSH) content of the rat that Alcoholic damages of 4 samples:
The hepatic tissue GSH content of liver injury model control rats is significantly lower than negative control group, and both difference has pole significance (P < 0.01), it was shown that liver injury model is set up.The hepatic tissue GSH content of matched group 1-3 rat is obviously higher than model control group, there are no significant (P > 0.05) for single difference, show the GSH content tool effect of improving in the liver tissues of rats that Alcoholic is damaged by this sample, but be not as obvious.The difference of experimental group and model control group is respectively provided with pole significance (P < 0.01), it was shown that this sample has the effect of GSH content in the liver tissues of rats improving alcoholic liver injury.
5 samples impact on the hepatic tissue steatosis of alcoholic liver injury in rats: liver damages the hepatic tissue Steatosis score value of model control group rat and is significantly higher than negative control group, both difference has pole significance (P < 0.01), it was shown that liver damages model and sets up.The hepatic tissue Steatosis score value of matched group 1-3 rat is below liver injury model matched group, but there are no significant (P > 0.05) for the difference of each group and liver injury model matched group, show in the liver tissues of rats that Alcoholic is damaged by this sample that steatosis has and necessarily alleviate effect, but be not as obvious.The hepatic tissue Steatosis score value of experimental group rat damages model control group lower than liver, and the difference of each dosage group and model control group is respectively provided with pole significance (P < 0.01), it was shown that this sample has the effect of the liver tissues of rats steatosis alleviating alcoholic liver injury.
6 brief summaries: the health food granule of the embodiment of the present invention 10 preparation can reduce triglyceride (TG) content in the hepatic tissue of alcoholic liver injury rat model, improve Reductive glutathione (GSH) content in its hepatic tissue, alleviate the steatosis degree of its hepatic tissue, the body weight of rat is had no significant effect.As can be seen here, this sample has and alcoholic liver injury is had assistant protection function.
Experimental example 2 toxicity test
Laboratory sample: the health food granule of embodiment 10 preparation, recommends consumption for everyone (adult) every day 3 times by human body, and each 20g is converted to 1g/kg BW by 60kg body weight.
Experimental technique: carrying out Toxicological evaluation according to " health food inspection and assessment technique specification " (version in 2003) pertinent regulations, result is as follows:
1. acute toxicity test: the acute oral of mice female, male be experiments show that, belongs to non-poisonous material.
2. three genetic toxicity tests: three genetic toxicity test (Salmonella reversion test, mice bone marrow micronucleus, mouse inbred strain) results are feminine gender.
During 3.30 days feeding trials, each dosage group rat body weight increases, food utilization compares with matched group and there was no significant difference (P > 0.05).Mus blood biochemistry index female, male, routine blood indexes and liver/body, spleen/body, kidney/body, there are no significant with matched group comparing difference (P > 0.05) for male Mus testis/body ratio.Liver,spleen,kidney, Stomach duodenum, testis (ovary) tissue pathology checking are without obvious damage.
Experimental example 3 human experiment is tested
Selecting the male alcoholic liver patient at 43 years old～69 years old 33 example age, 51.7 years old mean age, without other serious disease.Select alcoholic liver patient criteria: patient has for a long time, the history of heavy drinking, 40 ° of Chinese liquor every days more than 2 liang, last more than 3 years；Inappetence, fatigue and weak, lean body mass；There are slight or moderate liver fibrosis；Serum glutamic oxalacetic transaminase significantly increases, and glutamate pyruvate transaminase is normal, ratio between two 2: 1～5: 1.
Efficacy determination: effective: stop excessive drinking；Transference cure appetite is good, and fatigue and weak disappears, with it energetically；Become thin improvement, physical comfort；Hepatic fibrosis checks that 4 indexs are all qualified；Glutamic oxaloacetic transaminase, GOT is remarkably decreased, with the ratio < 2: 1 of glutamate pyruvate transaminase.Effective: excessive drinking reduces, and inappetence, fatigue and weak, lean body mass are alleviated to some extent；GVG transaminase declines more than 10%, but not up to effective standard.Invalid: continuing excessive drinking, symptom is unchanged.
During test-meal test, withdraw other medicines and nutrient and healthcare products, take the health food granule of the embodiment of the present invention 10 preparation, every day 3 times, each 20g, after meal warm boiled water；Observing 6 months is 1 cycle.After 2 months, namely symptom has alleviation, and after taking 6 months, symptom is substantially alleviated.In 33 people of clinical experiment, effective 10 people, effective 18 people, invalid 5 people, total effective rate 84.85%.
This experimental example is taked the dosage form of granule, make drug administration simple and easy, effectively raise absorption and the utilization of medicine, additionally, what the present invention taked is pure natural medical, without any poisonous additive and addictive drug, will not appetite-suppressing, it is not result in diarrhoea, has no side effect, not addiction.Also finding during experiment, the body weight of major part experimental group experimenter alleviates to some extent, and blood fat, blood pressure have and reduce in various degree, and digestion all has improvement, and mental attitude significantly improves, and the prompting present invention also has the health-care effects such as blood fat reducing, blood pressure lowering and fat-reducing.
Although, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (9)
1. a health food with the liver protecting function, it is characterised in that its raw material includes Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus, Cordyceps mycelium powder, concentrated lactoalbumin, soybean protein isolate, VC, taurine, VB2, biotin, dextrinosan, lycopene, apple polyphenol.
2. health food according to claim 1; it is characterized in that, include Fructus Schisandrae Chinensis 10-200 part, Ganoderma 10-200 part, Moringa 10-150 part, Maca 10-150 part, cervus elaphus linnaeus 5-50 part, Cordyceps mycelium powder 5-50 part, concentrated lactoalbumin 5-50 part, soybean protein isolate 5-50 part, VC0.0001-0.0005 part, taurine 0.0005-0.005 part, VB with its raw material of parts by weight20.0005-0.005 part, biotin 0.0005-0.005 part, dextrinosan 0.1-5 part, lycopene 0.01-0.1 part, apple polyphenol 0.01-0.1 part.
3. health food according to claim 2; it is characterized in that, include Fructus Schisandrae Chinensis 50-150 part, Ganoderma 50-150 part, Moringa 20-100 part, Maca 20-100 part, cervus elaphus linnaeus 10-40 part, Cordyceps mycelium powder 10-40 part, concentrated lactoalbumin 10-40 part, soybean protein isolate 10-40 part, VC0.0001-0.0005 part, taurine 0.001-0.005 part, VB with its raw material of parts by weight20.001-0.005 part, biotin 0.001-0.005 part, dextrinosan 1-5 part, lycopene 0.02-0.08 part, apple polyphenol 0.02-0.08 part.
4. health food according to claim 3; it is characterized in that, include Fructus Schisandrae Chinensis 70 parts, Ganoderma 120 parts, Moringa 80 parts, Maca 35 parts, cervus elaphus linnaeus 15 parts, Cordyceps mycelium powder 20 parts, concentrated lactoalbumin 15 parts, soybean protein isolate 25 parts, VC0.0003 part, taurine 0.002 part, VB with its raw material of parts by weight20.003 part, biotin 0.002 part, dextrinosan 3 parts, lycopene 0.05 part, apple polyphenol 0.03 part.
5. the health food according to any one of claim 1-4, it is characterised in that its raw material or adjuvant also include pharmaceutically or acceptable carrier on food or on health food.
6. the health food according to any one of claim 1-4, it is characterised in that described health food is formed into oral formulations；Including: capsule, granule, tablet, packed medicinal tea, powder.
7. the health food according to any one of claim 1-6, it is characterised in that its raw material of described health food or adjuvant also include microcrystalline Cellulose, magnesium stearate.
8. the preparation method of health food described in any one of claim 1-7, it is characterised in that comprise the following steps:
1) dispensing；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, 50%-90% alcohol reflux 1-3 time of 5-10 times of weight is added, each 0.5-3.0 hour, filtration, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste, adds ethanol and makes alcohol content reach 70%-75%, obtains solution I；
3) by step 2) gained filtering residue adds soak by water 1-3 time of 5-15 times of weight, and each 0.5-2 hour, collecting decoction, filter, concentrate the filtrate to clear paste, add ethanol and make alcohol content reach 70%-75%, obtain solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste；Add all the other raw materials by formula and appropriate amount of auxiliary materials makes suitable dosage form；Preferably, add appropriate microcrystalline Cellulose, magnesium stearate, make granule.
9. the preparation method of health food according to claim 8, it is characterised in that comprise the following steps:
1) dispensing；
2) by after Fructus Schisandrae Chinensis, Ganoderma, Moringa, Maca, cervus elaphus linnaeus mixing, with 70%-75% alcohol reflux 2 times, adding 8 times of w ethanol the 1st time and extract 3h, add 6 times of w ethanol the 2nd time and extract 1h, filter, filtering residue is standby；Merging filtrate, concentrates the filtrate to clear paste, adds ethanol and makes alcohol content reach 70%-75%, obtains solution I；
3) by step 2) gained filtering residue boiling 2 times, add 10 times of weight water the 1st time and decoct 2h, add 8 times of w ethanol for the 2nd time and extract 1h, collecting decoction, filter, concentrate the filtrate to clear paste, add ethanol and make alcohol content reach 70%-75%, obtain solution II；
4) merge described solution I and solution II, stir evenly, stand, filter, filtrate recycling ethanol, be concentrated into clear paste；Add all the other raw materials by formula and appropriate amount of auxiliary materials makes suitable dosage form；Preferably, add appropriate microcrystalline Cellulose, magnesium stearate, make granule.
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| CN201610068821.8A CN105709210A (en) | 2016-02-01 | 2016-02-01 | Health food with liver protection function |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610068821.8A Pending CN105709210A (en) | 2016-02-01 | 2016-02-01 | Health food with liver protection function |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109275714A (en) * | 2018-11-29 | 2019-01-29 | 扬州市扬大康源乳业有限公司 | A kind of relieving alcoholism and protecting liver Yoghourt and preparation method thereof |
| CN109549214A (en) * | 2017-09-26 | 2019-04-02 | 深圳杏林春暖科技股份有限公司 | A kind of composition and health care product adjusting the five internal organs |
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| CN103948028A (en) * | 2014-04-20 | 2014-07-30 | 江苏康缘药业股份有限公司 | Composition with efficacy of relieving liver injury and preparation method and content determination method thereof |
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| CN101803730A (en) * | 2009-11-12 | 2010-08-18 | 天津市百奥生物技术有限公司 | Health care food with auxiliary protection role on chemical liver injury and preparation method thereof |
| CN103948028A (en) * | 2014-04-20 | 2014-07-30 | 江苏康缘药业股份有限公司 | Composition with efficacy of relieving liver injury and preparation method and content determination method thereof |
| CN104055845A (en) * | 2014-07-10 | 2014-09-24 | 饶长军 | Composition for treating diseases of heart and cerebral vessel, liver and kidney and boosting immunity and preparation thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109549214A (en) * | 2017-09-26 | 2019-04-02 | 深圳杏林春暖科技股份有限公司 | A kind of composition and health care product adjusting the five internal organs |
| CN109275714A (en) * | 2018-11-29 | 2019-01-29 | 扬州市扬大康源乳业有限公司 | A kind of relieving alcoholism and protecting liver Yoghourt and preparation method thereof |
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Application publication date: 20160629 |