CN116407602B - Traditional Chinese medicine composition for sweating and defervescing and preparation method thereof - Google Patents
Traditional Chinese medicine composition for sweating and defervescing and preparation method thereof Download PDFInfo
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- CN116407602B CN116407602B CN202310214084.8A CN202310214084A CN116407602B CN 116407602 B CN116407602 B CN 116407602B CN 202310214084 A CN202310214084 A CN 202310214084A CN 116407602 B CN116407602 B CN 116407602B
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- Medicines Containing Plant Substances (AREA)
Abstract
The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for sweating and defervescing and a preparation method thereof. The traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight: 3 to 6 parts of ligusticum, 6 to 9 parts of radix scutellariae, 6 to 9 parts of willow root, 3 to 6 parts of whole dyers woad leaf plant, 3 to 6 parts of dandelion, 3 to 6 parts of loquat leaf, 3 to 6 parts of plantain herb, 1 to 3 parts of bamboo leaf, 1 to 3 parts of common cephalanoplos herb, 3 to 6 parts of glabrous greenbrier rhizome, 3 to 6 parts of radix asparagi and 3 to 6 parts of gardenia. The traditional Chinese medicine composition provided by the application can stimulate blood vessel expansion to promote blood circulation, stimulate pores and sweat glands on the surface of a human body to increase body surface humidity, so that a patient can quickly sweat and defer heat, the traditional Chinese medicine composition is very suitable for coping with fever symptoms caused by new coronaries and being applied to preparing a medicament for sweating and defervescing, and the preparation method disclosed by the application is utilized to ensure that the traditional Chinese medicine composition has the advantages of good water solubility and easiness in taking, and can better exert the efficacy of sweating and defervescing.
Description
Technical Field
The application belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for sweating and defervescing and a preparation method thereof.
Background
Zhang Zhongjing is taught in the book of Shang Han Lun and Suan Bing Zhong, on the surface of the vessel, it can induce sweat, so it is suitable for Ma Huang Tang, and the "sweating method" is the earliest and most widely used treatment method for bringing down fever. The traditional Chinese medicine considers that the "sweating method" not only has the functions of dredging the channels and activating collaterals, activating whole body organs, improving spirit and restoring physical strength, but also has the functions of regulating nerves, expanding peripheral small blood vessels, improving microcirculation system, promoting the functions of human internal organs and six fu organs, and leading internal evil to be discharged along with evaporated sweat.
And the fever is reduced, namely the body temperature is reduced, so that the fever is reduced to normal, and the fever is generally caused by contacting with pyrogen, and the pyrogen causes the temperature setting point to move upwards, so that the regulatory body temperature is increased. In view of the fact that the prior patient has common fever and high fever, and the high fever lasts for a relatively long time, it is necessary to provide a traditional Chinese medicine composition capable of rapidly bringing down fever and mild in efficacy.
In addition, the traditional Chinese medicine composition in the prior art, especially the powdery traditional Chinese medicine composition without extracting the effective components of the traditional Chinese medicine, has the problem of poor water solubility, and more residues are formed when the traditional Chinese medicine composition is taken with hot water, so that firstly, the traditional Chinese medicine active components of the oral administration of a patient are not high, secondly, the oral administration process of the traditional Chinese medicine composition is difficult, and the oral administration of the traditional Chinese medicine composition is poor in taste, so that the use feeling of the patient is poor, and therefore, the preparation method is also necessary to be improved to improve the water solubility of the traditional Chinese medicine composition.
Disclosure of Invention
In order to solve the problems, the traditional Chinese medicine composition for sweating and defervescing and the preparation method thereof are provided, the traditional Chinese medicine composition can stimulate blood vessel to dilate so as to promote blood circulation, stimulate pores and sweat glands on the surface of a human body and increase body surface humidity so as to enable a patient to sweat and defervesce rapidly, and the traditional Chinese medicine composition prepared by the preparation method can be directly taken with water and has small amount of insoluble residues, so that the traditional Chinese medicine composition is convenient to take and has good efficacy.
On one hand, the application provides a traditional Chinese medicine composition for sweating and defervescing, which comprises the following raw materials in parts by weight:
3 to 6 parts of ligusticum, 6 to 9 parts of radix scutellariae, 6 to 9 parts of willow root, 3 to 6 parts of whole dyers woad leaf plant, 3 to 6 parts of dandelion, 3 to 6 parts of loquat leaf, 3 to 6 parts of plantain herb, 1 to 3 parts of bamboo leaf, 1 to 3 parts of common cephalanoplos herb, 3 to 6 parts of glabrous greenbrier rhizome, 3 to 6 parts of radix asparagi and 3 to 6 parts of gardenia.
Optionally, the raw materials comprise the following components in parts by weight: 6 parts of ligusticum, 9 parts of radix scutellariae, 9 parts of willow root, 6 parts of whole dyers woad leaf plant, 6 parts of dandelion, 6 parts of loquat leaf, 6 parts of plantain herb, 3 parts of bamboo leaf, 3 parts of common cephalanoplos herb, 6 parts of glabrous greenbrier rhizome, 6 parts of radix asparagi and 6 parts of gardenia.
Optionally, the raw materials comprise the following components in parts by weight: 3 parts of ligusticum, 6 parts of radix scutellariae, 6 parts of willow root, 3 parts of whole dyers woad leaf plant, 3 parts of dandelion, 3 parts of loquat leaf, 3 parts of plantain herb, 1 part of bamboo leaf, 1 part of common cephalanoplos herb, 3 parts of glabrous greenbrier rhizome, 3 parts of radix asparagi and 3 parts of gardenia.
On the other hand, the application provides a preparation method of the traditional Chinese medicine composition for sweating and antipyresis, which comprises the following steps:
1) Weighing the raw materials according to the weight portion ratio, grinding the raw materials into powder, wherein the grinding time is 3-5 min, and the grinding speed is 10000-20000 rpm, and mixing the raw materials to obtain mixture powder;
2) Steaming the mixture powder at the temperature of 80-90 ℃ for 1-3 hours;
3) Freeze-drying the steamed mixture powder at-40 to-30 ℃ and at the drying pressure of 200-300 Pa and the drying temperature of 10-20 ℃ and then carrying out secondary grinding to obtain the traditional Chinese medicine composition.
Optionally, the secondary grinding is carried out at a grinding speed of 3000-7000 rpm for 1-3 min.
Optionally, the step 1) further comprises the following cleaning steps: the ligusticum, the radix scutellariae, the willow roots, the rhizoma smilacis glabrae and the gardenia in the raw materials are washed, cut into blocks, soaked in warm water at 30-40 ℃ for 4-6 hours, dried, and the rest raw materials are washed and dried.
Optionally, the grinding conditions in step 1) are: the grinding time was 4min and the grinding speed was 15000rpm.
Optionally, the steaming temperature in the step 2) is 85 ℃, and the steaming time is 2 hours.
Optionally, the conditions of the freeze-drying in the step 3) are as follows: cooling temperature-35 deg.c, drying pressure 250Pa and drying temperature 15 deg.c.
In still another aspect, the present application provides a use of the above-mentioned Chinese medicinal composition and the Chinese medicinal composition prepared by the above-mentioned preparation method in preparing a medicament for treating fever symptoms, preferably fever symptoms including fever symptoms caused by wind-heat and viruses, more preferably, viruses including coronavirus, respiratory syncytial virus, influenza virus and adenovirus, and even more preferably, coronavirus is SARS-CoV-2.
The Chinese medicinal materials used in the application have the following properties:
Ligusticum sinense has bitter and cool property, enters meridians of liver, stomach, lung and large intestine, has the effects of clearing heat and detoxicating, inducing diuresis and relieving swelling, resolving phlegm and relieving cough, and is mainly used for treating diseases such as pharyngitis, pyocutaneous disease, carbuncle, scrofula, cough due to lung heat, edema and the like caused by heat toxin.
Radix Scutellariae: bitter in property and cold in nature, enter meridians of stomach, liver and lung, and have the effects of clearing heat and detoxicating, cooling blood and stopping bleeding, and clearing heat and detoxicating, and can be used for treating symptoms such as sore throat, toothache, hematemesis, epistaxis, heat toxin rash and the like caused by heat toxin.
Willow root: bitter in property and cold in nature, enter meridians of liver, stomach and kidney, and have the effects of clearing heat and detoxicating, cooling blood and stopping bleeding, and activating blood and dissolving stasis, and can be used for treating bleeding, heat toxin rash, traumatic injury and other diseases caused by heat toxin.
All-grass of Lawsonia inermis: bitter and cold property, enter lung, liver, stomach and large intestine meridian, and has the effects of clearing heat and detoxicating, detumescence and detoxication, and is mainly used for treating carbuncle, sore and ulcer, sore throat, heat toxin rash and other diseases caused by heat toxin.
Dandelion: bitter in property and cold in nature, enter meridians of liver, stomach and lung, and have the effects of clearing heat and detoxicating, relieving swelling and promoting urination, and activating blood circulation to dissipate blood stasis, and can be used for treating sores and ulcers, carbuncles, swelling, damp-heat of liver and gallbladder, traumatic injuries, blood stasis and other diseases caused by heat toxin.
Loquat leaves: the medicine has the effects of clearing heat and detoxicating, moistening lung and relieving cough, resolving phlegm and quenching thirst, invigorating stomach and promoting fluid production, and is mainly used for treating diseases such as yin injury, cough due to lung heat, sore throat, thirst, dyspepsia, gastralgia, constipation and the like.
Herb of plantain: sweet and cold nature, and enters the channels of lung, stomach, kidney and bladder, and has the effects of clearing heat and detoxicating, inducing diuresis to alleviate edema, nourishing yin and moistening dryness, and is mainly used for treating symptoms such as difficult urination, lymphadenitis, dyspepsia, thirst, cough and the like caused by heat toxin.
Bamboo leaves: the medicine has sweet, slightly bitter and cool properties, and enters channels of lung, stomach, heart, liver and kidney, has the effects of clearing heat, promoting the circulation of the throat, dispersing lung qi, relieving cough, inducing diuresis to alleviate edema, and is mainly used for treating sore throat, dry mouth cough, lung heat, asthma and cough, edema, difficult urination and stranguria with turbid urine.
Herba Cephalanoploris: bitter in property and slightly cold in nature, enters meridians of liver, stomach and large intestine, has the effects of clearing heat and detoxicating, inducing diuresis and detumescence, cooling blood and stopping bleeding, reducing blood lipid and lowering blood pressure, and is mainly used for treating heat toxin and stasis arthralgia, damp-heat of liver and gall, edema, acute mastitis, hemorrhoids, hypertension and hyperlipidemia.
Rhizoma smilacis glabrae: sweet, bland and flat property, has the effects of inducing menstruation, removing dampness by diuresis, strengthening spleen and stomach, soothing nerves and stabilizing mind, and is mainly used for treating edema, damp phlegm, weakness of spleen and stomach, palpitation and insomnia, seminal emission and frequent urination and hemorrhoids bleeding.
Radix asparagi: sweet, light and flat property, and has the effects of clearing heat and moistening lung, relieving cough and reducing sputum, nourishing yin and moistening dryness, and is mainly used for treating cough with lung heat, excessive phlegm, dry cough, pharyngitis, thirst and dry throat, dysphoria with smothery sensation, thirst, oliguria with reddish urine and chronic dysentery.
Gardenia jasminoides ellis: bitter in property, cold in nature, enters stomach, liver and large intestine meridians, has the effects of clearing heat and detoxicating, removing food retention and removing stagnation, promoting qi circulation and relieving pain, and is mainly used for treating heat toxin sore swelling, chest and hypochondrium food stagnation, abdominal pain and constipation, jaundice, carbuncle and furuncle, malaria, toothache, dysmenorrhea and traumatic injury.
The beneficial effects of the application include, but are not limited to:
1. According to the traditional Chinese medicine composition for sweating and defervescing, the willow roots in the raw materials are not recorded in the formula for sweating and defervescing, in addition, in the scheme of the application, the whole dyers woad leaf plant is matched with the willow roots, compared with the radix isatidis, the drug effect of the whole dyers woad leaf plant is milder, the gastrointestinal tract and the liver and kidney cannot be stimulated too much, and the two active ingredients can stimulate skin pores of a human body to be opened, and stimulate sweat glands to increase the humidity of the skin surface, so that the sweating effect is promoted; in addition, the components such as flavonoid, alkaloid and the like in the traditional Chinese medicine composition can stimulate blood vessel expansion to increase blood flow, can accelerate heat emission and sweat excretion by promoting metabolism of a body, and the regulating factors such as saponin and the like in the traditional Chinese medicine composition can regulate human body temperature regulating centers and adrenaline systems, so that the processes of sweating and defervescing are accelerated, and the traditional Chinese medicine composition can effectively play roles of sweating and defervescing.
2. According to the traditional Chinese medicine composition for sweating and fever abatement, other traditional Chinese medicine components except smilax glabra and radix asparagi are cold in nature, and smilax glabra and radix asparagi are slightly cold or flat in nature, and the traditional Chinese medicine composition can be milder in efficacy by adding smilax glabra and radix asparagi and being matched with other medicinal materials, can reduce excessive irritation to intestines and stomach of patients caused by excessive cold in nature, can enhance gastrointestinal peristalsis of the patients, and is very suitable for patients with persistent high fever, inappetence and yang deficiency constitution.
3. According to the preparation method of the traditional Chinese medicine composition for sweating and antipyresis, for the key grinding steps, if the grinding degree of powder is too large, the specific surface area of the powder is too large, the acting force among the medicine powder is too strong, the powder forms insoluble block aggregates in the process of taking with water, if the grinding degree is insufficient, the particle size of the powder is too large, the effect of contacting with water is weak, the water solubility is poor, larger medicine residues are formed, the taking effect and the taste are affected, and by selecting proper grinding conditions, the particle size range of the traditional Chinese medicine composition powder is moderate, the contact site with water is large, and the self agglomeration caused by the too large specific surface area is avoided, so that the medicine residues in the process of taking with hot water are obviously reduced.
4. According to the preparation method of the traditional Chinese medicine composition capable of sweating and defervescing, disclosed by the application, the traditional Chinese medicine is further steamed after being ground to form powder, so that the drug effect of the traditional Chinese medicine powder can be improved, the inside of the powdery traditional Chinese medicine is looser under the impact of water vapor molecules, more pores are generated in the powder, the traditional Chinese medicine composition is freeze-dried after being steamed, the structure of the traditional Chinese medicine composition subjected to the impact of the water vapor molecules can shrink under the low-temperature condition, but the pores still exist, so that when the traditional Chinese medicine composition powder is taken after being added into water, the powder has a large number of pores, the powder can absorb water rapidly to expand, the combination effect of the powder and water is stronger, the drug residue is not easy to form, the particle size of the ground traditional Chinese medicine composition powder can influence the impact effect of the water vapor on the powder in the steaming process, if the particle size of the powder is too large, the water vapor cannot act into the powder, the pore generation amount is small, if the particle size of the powder is too small, the powder is broken into smaller powder, the specific surface area of the powder is too large, and the self-agglomeration of the traditional Chinese medicine powder is caused.
5. According to the preparation method of the traditional Chinese medicine composition for sweating and antipyresis, a freeze-drying mode is adopted after steaming, and the volume of liquid water becomes large when the water turns into a solid state in the freezing process, so that after pores are formed on the surface of powder particles produced by steaming, the state of the pores can be further maintained by further adopting the freeze-drying mode, and the pore retention is further promoted due to the increase of the volume, the pore closure in the drying process is avoided, and the water solubility of the powder in the process of taking with water is improved.
6. According to the preparation method of the traditional Chinese medicine composition capable of sweating and defervescing, secondary grinding is further included after freeze-drying, and because the powder forms larger caking in the freeze-drying process, the dispersibility among particles is poor, the secondary grinding is carried out, the grinding condition is controlled to be mild, the microstructure of the traditional Chinese medicine composition powder is basically not affected, but the caking phenomenon caused by removing moisture after steaming can be eliminated, the dispersion effect of the traditional Chinese medicine composition powder is improved, the water solubility of the traditional Chinese medicine composition is further improved, and the generation amount of dregs in the process of taking with water is greatly reduced.
Detailed Description
The present application is described in detail below with reference to examples, but the present application is not limited to these examples.
Unless otherwise indicated, the starting materials and reagents in the examples of the application were all purchased commercially.
The freeze-dryer used in the examples and comparative examples described below was LGJ-10FD conventional, purchased from Huaxing technology development Co., ltd. In Beijing pine source, the grinder used was CTS grinder, purchased from Qingdao Chunter machine Co., ltd. For the Chinese medicinal materials used in the examples and comparative examples, they were commercially available, for example, at a Chinese medicinal store or a Chinese medicinal material supplier.
Example 1
1) Pretreatment of traditional Chinese medicinal materials: respectively taking rhizoma Ligustici, radix Scutellariae, willow root, folium Isatidis whole plant, herba Taraxaci, folium Eriobotryae, herba plantaginis, folium Bambusae, herba Cephalanoploris, rhizoma Smilacis Glabrae, radix asparagi and fructus Gardeniae, cleaning rhizoma Ligustici, radix Scutellariae, radix Salicis Babylonicae, rhizoma Smilacis Glabrae and fructus Gardeniae, cutting into pieces, soaking in 35 deg.C warm water for 5 hr, drying, cleaning the rest materials, and air drying;
2) Grinding into powder: preparing a traditional Chinese medicine composition according to the following proportion, wherein the traditional Chinese medicine composition comprises 3g of ligusticum, 6g of radix scutellariae, 6g of willow root, 3g of whole dyers woad leaf plant, 3g of dandelion, 3g of loquat leaf, 3g of plantain herb, 2g of bamboo leaf, 2g of common cephalanoplos herb, 3g of glabrous greenbrier rhizome, 3g of radix asparagi and 3g of gardenia, and grinding the materials into powder at room temperature for 4min at a grinding speed of 15000rpm;
3) Steaming with steam: placing the traditional Chinese medicine powder in a container, placing the container filled with the traditional Chinese medicine powder in a steamer for steaming for 2 hours at the steaming temperature of 85 ℃ and keeping water vapor uninterrupted in the whole steaming process;
4) And (3) freeze-drying: cooling the steamed Chinese medicinal composition powder, and drying at-35deg.C under the drying pressure of 250Pa at 15deg.C;
5) Secondary grinding: grinding the freeze-dried traditional Chinese medicine composition for 2min at a grinding speed of 5000rpm, and secondarily grinding to obtain the traditional Chinese medicine composition.
Example 2
1) Pretreatment of traditional Chinese medicinal materials: respectively taking rhizoma Ligustici, radix Scutellariae, willow root, folium Isatidis whole plant, herba Taraxaci, folium Eriobotryae, herba plantaginis, folium Bambusae, herba Cephalanoploris, rhizoma Smilacis Glabrae, radix asparagi and fructus Gardeniae, cleaning rhizoma Ligustici, radix Scutellariae, radix Salicis Babylonicae, rhizoma Smilacis Glabrae and fructus Gardeniae, cutting into pieces, soaking in 35 deg.C warm water for 5 hr, drying, cleaning the rest materials, and air drying;
2) Grinding into powder: preparing a traditional Chinese medicine composition according to the following proportion, wherein the traditional Chinese medicine composition comprises 6g of ligusticum, 9g of radix scutellariae, 9g of willow root, 6g of whole dyers woad leaf, 6g of dandelion, 6g of loquat leaf, 6g of plantain herb, 3g of bamboo leaf, 3g of common cephalanoplos herb, 6g of glabrous greenbrier rhizome, 6g of radix asparagi and 6g of gardenia, and grinding the raw materials into powder at room temperature for 5min at a grinding speed of 10000rpm;
3) Steaming with steam: placing the traditional Chinese medicine powder in a container, placing the container filled with the traditional Chinese medicine powder in a steamer for steaming for 3 hours at the steaming temperature of 80 ℃ and keeping the water vapor uninterrupted in the whole steaming process;
4) And (3) freeze-drying: cooling and drying the steamed Chinese medicinal composition powder at-40deg.C under 300Pa and 20 deg.C, and cooling and drying to obtain the Chinese medicinal composition;
5) Secondary grinding: grinding the freeze-dried traditional Chinese medicine composition for 1min at 7000rpm, and performing secondary grinding to obtain the traditional Chinese medicine composition.
Example 3
1) Pretreatment of traditional Chinese medicinal materials: respectively taking rhizoma Ligustici, radix Scutellariae, willow root, folium Isatidis whole plant, herba Taraxaci, folium Eriobotryae, herba plantaginis, folium Bambusae, herba Cephalanoploris, rhizoma Smilacis Glabrae, radix asparagi and fructus Gardeniae, cleaning rhizoma Ligustici, radix Scutellariae, radix Salicis Babylonicae, rhizoma Smilacis Glabrae and fructus Gardeniae, cutting into pieces, soaking in 35 deg.C warm water for 5 hr, drying, cleaning the rest materials, and air drying;
2) Grinding into powder: preparing a traditional Chinese medicine composition according to the following proportion, wherein the traditional Chinese medicine composition comprises 4g of ligusticum, 7g of radix scutellariae, 7g of willow root, 4g of whole dyers woad leaf, 4g of dandelion, 4g of loquat leaf, 4g of plantain herb, 2g of bamboo leaf, 2g of common cephalanoplos herb, 4g of glabrous greenbrier rhizome, 4g of radix asparagi and 4g of gardenia, and grinding the raw materials into powder at room temperature for 3min at a grinding speed of 20000rpm;
3) Steaming with steam: placing the traditional Chinese medicine powder in a container, placing the container filled with the traditional Chinese medicine powder in a steamer for steaming for 1h at 90 ℃ with uninterrupted steam in the whole steaming process;
4) And (3) freeze-drying: freeze-drying the steamed Chinese medicinal composition powder at-30deg.C under 200Pa and at 10deg.C, and cooling and drying to obtain the Chinese medicinal composition;
5) Secondary grinding: grinding the freeze-dried traditional Chinese medicine composition for 3min at a grinding speed of 3000rpm, and secondarily grinding to obtain the traditional Chinese medicine composition.
Examples 4 to 11
Examples 4 to 11 are substantially identical to the preparation method of example 1, except that the grinding time and grinding speed in step 2), the steaming time and steaming temperature in step 3), and the freezing temperature, drying pressure and drying temperature of lyophilization in step 4) are set forth in table 1.
Example 12
This example is substantially identical to the preparation of example 1, except that step 5 is not included.
Comparative example 1
This comparative example is substantially identical to the preparation of example 1, except that steps 3), 4) and 5) are not employed.
Comparative example 2
The preparation method of this example is the same as that of example 1 except that in step 2), a Chinese medicinal composition comprising 3g of Ligusticum sinense, 6g of radix Scutellariae, 9g of whole plant of dyers woad leaf, 3g of dandelion, 3g of loquat leaf, 3g of plantain herb, 2g of bamboo leaf, 2g of herba Cephalanoploris, 3g of rhizoma Smilacis Glabrae, 3g of radix asparagi and 3g of gardenia is prepared according to the following proportion.
Comparative example 3
The preparation method of this example is the same as that of example 1 except that in step 2), a Chinese medicinal composition comprising 3g of Ligusticum sinense, 6g of radix Scutellariae, 9g of willow root, 3g of dandelion, 3g of loquat leaf, 3g of plantain herb, 2g of bamboo leaf, 2g of herba Cephalanoploris, 3g of rhizoma Smilacis Glabrae, 3g of radix asparagi and 3g of Gardenia jasminoides Ellis is prepared in the following proportion.
Comparative example 4
The preparation method of this example is the same as that of example 1 except that in step 2), the Chinese medicinal composition comprising Ligusticum sinense 4g, scutellariae radix 7g, dandelion 4g, folium Eriobotryae 3g, herba plantaginis 4g, herba Lophatheri 3g, herba Cephalanoploris 3g, rhizoma Smilacis Glabrae 4g, radix asparagi 4g and fructus Gardeniae 4g is formulated according to the following ratio.
Comparative example 5
This example is substantially the same as the preparation method of example 1 except that in step 2), a Chinese medicinal composition comprising Ligusticum sinense 4g, scutellariae radix 6g, willow root 6g, whole plant of dyers woad leaf 4g, dandelion 4g, loquat leaf 3g, plantain herb 4g, bamboo leaf 3g, herba Cephalanoploris 3g, and gardenia 3g is formulated in the following ratio.
Test example 1
The powder of the traditional Chinese medicine composition prepared in each example and the comparative example is dissolved in 300ml boiled water at 100 ℃, the adding amount of the powder is 30g, after the powder is stirred uniformly and dissolved fully, the powder is filtered by using 5 layers of medical gauze, insoluble residues are collected and weighed, after the boiled water is cooled to 40 ℃, the insoluble residues are filtered by adopting the same method, collected and weighed again, and the two insoluble residues are recorded respectively, so that the result is shown in Table 1.
TABLE 1
As is apparent from the data in Table 1, compared with comparative example 1, the water solubility of the traditional Chinese medicine composition prepared by the preparation method provided by the application is obviously improved, and the water solubility of the traditional Chinese medicine composition powder in boiling water at 100 ℃ is extremely low, and the amount of insoluble residues generated in the process of reducing the temperature to 40 ℃ which is warm water is extremely low.
Meanwhile, as can be seen from comparative examples 1 and 12, the secondary grinding of the powder of the Chinese medicinal composition after lyophilization improves the water solubility of the powder of the Chinese medicinal composition; as can be seen from comparative examples 1 and 4 to 11, the specific parameter conditions of the grinding step, the steaming step and the freeze-drying step have a great influence on the water solubility of the prepared powder of the Chinese medicinal composition, the insufficient grinding degree or the excessively strong grinding degree is not beneficial to improving the water solubility, the change of the internal structure of the powder is not great if the steaming is insufficient, the powder particles are broken if the steaming degree is too strong, the water solubility is not beneficial to improving, and in the freeze-drying step, if the temperature is not low enough, the maintenance effect of the solid ice after freeze-drying on the pores formed in the steaming process is poor, and if the temperature is too low, the more complicated drying time or the drying temperature is needed for the subsequent drying process; the drying temperature and drying time in the lyophilization step also have an effect on the water solubility of the pharmaceutical composition powder.
Meanwhile, as can be seen from comparative examples 1 and comparative examples 2 to 5, the formulation composition of the traditional Chinese medicine composition also affects the water solubility of the prepared traditional Chinese medicine composition powder, wherein the comparative examples 2 and 4 do not contain willow roots, the water solubility is good, the weight ratio of the willow root raw materials in comparative example 3 is large, so that the water solubility is poor, and in example 1, the good water solubility can be ensured, the content of the willow roots is enough, and the sweating and antipyretic effects of the traditional Chinese medicine composition can be exerted; the water solubility of the traditional Chinese medicine composition of comparative example 5 lacking radix asparagi and rhizoma smilacis glabrae does not show obvious difference with that of example 1. Therefore, from the viewpoint of water solubility, the powder of the traditional Chinese medicine composition prepared in examples 1 to 3 and comparative examples 2, 4 and 5 has better water solubility, and the amount of dregs generated in the process of taking with water is minimum.
Test example 2
70 Patients with fever were enrolled and randomly and equally divided into 7 groups of 10 persons each, and the time from taking the drug at 39.0 ℃ to bringing down to 37.0 ℃ was counted, patient selection criteria: 1. age 18-45 years old; 2. no other drugs are taken recently; patient exclusion criteria: 1. pregnant women or women in the recent period of pregnancy and lactation; 2. serious diseases such as heart, liver, kidney and hematopoietic system are combined; 3. mental patients; 4. allergic constitution or allergic to various drugs; 5. similar medicines are adopted recently, for example, medicines with related or antagonistic actions are taken, so that the curative effect of the medicines is difficult to judge, and the average fever reducing time of each group is counted and calculated, and the results are shown in table 2.
TABLE 2
As can be seen from the results shown in table 2, the traditional Chinese medicine composition provided by the present application can quickly bring down fever of patients, and compared with other comparative examples, the traditional Chinese medicine composition schemes in examples 1, 2 and 3 can quickly stimulate sweat glands and pores of patients, and according to the oral condition of patients in examples 1, 2 and 3, the humidity of the skin surface of the patients is rapidly increased after taking the traditional Chinese medicine composition, and a large amount of sweat drops are formed, and the patients can obviously feel that a large amount of sweat is discharged from the body after taking the traditional Chinese medicine composition for 1 hour. The patients in the group of comparative example 5 can quickly sweat and defer heat after taking the traditional Chinese medicine composition, but the symptoms of poor intestinal tract activity and inappetence appear in most of the patient reactions, and the symptoms of inappetence appear in the patients after adding the two traditional Chinese medicines of glabrous greenbrier rhizome and asparagus root in examples 1, 2 and 3 and comparative examples 2-5.
This is probably because in the traditional Chinese medicine composition of the application, other traditional Chinese medicinal materials except glabrous greenbrier rhizome and cochinchnese asparagus root are cold or cool, so that the traditional Chinese medicine composition has a better cooling effect on a patient with fever with yang deficiency constitution, but also has weak gastrointestinal activity due to the reason of medicine property, and the cold and cool medicine property of the traditional Chinese medicine composition can be well balanced by adding the medicinal materials with glabrous greenbrier rhizome and cochinchnese asparagus root, and the traditional Chinese medicine composition has the effects of promoting gastrointestinal peristalsis and enhancing appetite of the patient, and the patient can be effectively promoted to recover by stimulating appetite and eating due to the fact that the patient discharges more moisture, electrolyte and the like in the process of sweating and defervescing.
The above description is only an example of the present application, and the scope of the present application is not limited to the specific examples, but is defined by the claims of the present application. Various modifications and variations of the present application will be apparent to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the technical idea and principle of the present application should be included in the protection scope of the present application.
Claims (9)
1. The traditional Chinese medicine composition for sweating and reducing fever is characterized by being prepared from the following raw materials in parts by weight:
3-6 parts of ligusticum, 6-9 parts of radix scutellariae, 6-9 parts of willow root, 3-6 parts of whole dyers woad leaf plant, 3-6 parts of dandelion, 3-6 parts of loquat leaf, 3-6 parts of plantain herb, 1-3 parts of bamboo leaf, 1-3 parts of common cephalanoplos herb, 3-6 parts of glabrous greenbrier rhizome, 3-6 parts of radix asparagi and 3-6 parts of gardenia;
the preparation method of the traditional Chinese medicine composition comprises the following steps:
1) Weighing the raw materials according to the weight portion ratio, grinding the raw materials into powder, wherein the grinding time is 3-5 min, the grinding speed is 10000-20000 rpm, and mixing the raw materials to obtain mixture powder;
2) Steaming the mixture powder at the temperature of 80-90 ℃ for 1-3 hours;
3) And freeze-drying the steamed mixture powder, wherein the freezing temperature is-40 to-30 ℃, the drying pressure is 200-300 Pa, the drying temperature is 10-20 ℃, and then secondary grinding is carried out to obtain the traditional Chinese medicine composition.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight:
6 parts of ligusticum, 9 parts of scutellaria baicalensis, 9 parts of willow root, 6 parts of dyers woad leaf whole plant, 6 parts of dandelion, 6 parts of loquat leaf, 6 parts of plantain herb, 3 parts of bamboo leaf, 3 parts of common cephalanoplos herb, 6 parts of glabrous greenbrier rhizome, 6 parts of radix asparagi and 6 parts of gardenia.
3. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight:
3 parts of ligusticum, 6 parts of radix scutellariae, 6 parts of willow root, 3 parts of whole dyers woad leaf plant, 3 parts of dandelion, 3 parts of loquat leaf, 3 parts of plantain herb, 1 part of bamboo leaf, 1 part of common cephalanoplos herb, 3 parts of glabrous greenbrier rhizome, 3 parts of radix asparagi and 3 parts of gardenia.
4. The method for preparing the traditional Chinese medicine composition for sweating and defervescing according to any one of claims 1-3, which is characterized by comprising the following steps:
1) Weighing the raw materials according to the weight portion ratio, grinding the raw materials into powder, wherein the grinding time is 3-5 min, the grinding speed is 10000-20000 rpm, and mixing the raw materials to obtain mixture powder;
2) Steaming the mixture powder at the temperature of 80-90 ℃ for 1-3 hours;
3) And freeze-drying the steamed mixture powder, wherein the freezing temperature is-40 to-30 ℃, the drying pressure is 200-300 Pa, the drying temperature is 10-20 ℃, and then secondary grinding is carried out to obtain the traditional Chinese medicine composition.
5. The method according to claim 4, wherein the secondary polishing is performed at a polishing rate of 3000 to 7000rpm for a period of 1 to 3 minutes.
6. The method of claim 4, further comprising the step of cleaning prior to step 1): cleaning rhizoma ligustici, radix scutellariae, willow roots, rhizoma smilacis glabrae and fructus gardeniae in raw materials, cutting into blocks, soaking in warm water at 30-40 ℃ for 4-6 hours, drying, cleaning the rest other raw materials, and drying.
7. The method according to claim 4, wherein the grinding conditions in step 1) are: the grinding time was 4min and the grinding speed was 15000rpm.
8. The method according to claim 4, wherein the steaming temperature in the step 2) is 85 ℃ and the steaming time is 2 hours.
9. The method according to claim 4, wherein the lyophilization conditions in step 3) are as follows: cooling temperature-35 deg.c, drying pressure 250Pa and drying temperature 15 deg.c.
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