CN116077603A - Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis, which is mainly prepared from the following raw materials in parts by weight: 5-15 parts of roasted astragalus root, 4-6 parts of dangshen, 4-6 parts of bighead atractylodes rhizome, 2-4 parts of dried orange peel, 4-6 parts of Chinese lobelia herb, 5-15 parts of hedyotis diffusa, 5-15 parts of dandelion, 5-15 parts of fried rice sprout, 5-15 parts of roasted malt, 1-3 parts of fructus amomi, 2-4 parts of costus root and 0.5-1.5 parts of pseudo-ginseng. In addition, the invention also discloses a preparation method of the traditional Chinese medicine composition. Clinical experiments prove that the effective rate of the treatment group (the traditional Chinese medicine composition) for treating the chronic atrophic gastritis is 96.43% under the gastroscope, which is far more than 76% of the effective rate of the control group adopting folic acid combined with the gastric rejuvenation, and the treatment effect of the chronic atrophic gastritis which is unexpected in the field is achieved.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic atrophic gastritis. In addition, the invention also relates to a preparation method of the traditional Chinese medicine composition.
Background
Chronic atrophic gastritis is a common and problematic disease of the digestive system, and is a major premalignant disease. The occurrence and development of gastric cancer mostly follow a five-step mode of "normal gastric mucosa-chronic superficial gastritis-chronic atrophic gastritis-intestinal metaplasia-dysplasia-gastric cancer". Since the disease is hidden and most cases are found at the late stage, gastric cancer is a malignant tumor with the death rate of 3 rd position in China, and huge medical resources are consumed. The early discovery and blocking of chronic atrophic gastritis progression is a key to preventing and treating gastric cancer and reducing mortality of gastric cancer.
Preventing and treating chronic atrophic gastritis is a key link for preventing and treating early gastric cancer. At present, no specific medicine exists for the chronic atrophic gastritis in modern medicine, western medicine treatment mainly comprises eradicating helicobacter pylori treatment, supplementing vitamins, symptomatic treatment, and regularly perfecting gastroscopy and pathological biopsy to monitor disease development, and surgical treatment is carried out if necessary, but the current Western medicine treatment has an inaccurate curative effect on the chronic atrophic gastritis.
The chronic atrophic gastritis is an important chronic disease of the digestive system, and the traditional Chinese medicine has reliable curative effect in treating the chronic atrophic gastritis, can effectively relieve clinical symptoms, improve gastric mucosal lesions, block gastric 'inflammation-cancer' transformation and reduce the prevalence rate of gastric cancer. The key pathogenesis of the disease is the internal accumulation of vital qi deficiency and toxin stasis, and the method of tonifying qi and strengthening spleen and removing toxin and stasis can effectively block and reverse the conversion of chronic atrophic gastritis 'inflammation-cancer'.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention aims at the key pathogenesis of the chronic atrophic gastritis, which is caused by deficiency of vital energy and internal stagnation of toxin and blood stasis, and simultaneously has the effects of invigorating qi and strengthening spleen, clearing heat and detoxicating, activating spleen and stomach, and promoting blood circulation to remove blood stasis, and is applied to the traditional Chinese medicine composition for treating chronic atrophic gastritis or intestinal epithelial metaplasia and atypical hyperplasia and the preparation method thereof.
The technical scheme adopted by the invention for solving the technical problems is as follows:
in one aspect of the invention, a traditional Chinese medicine composition for treating chronic atrophic gastritis is provided, which is mainly prepared from the following raw materials in parts by weight: 5-15 parts of roasted astragalus root, 4-6 parts of dangshen, 4-6 parts of bighead atractylodes rhizome, 2-4 parts of dried orange peel, 4-6 parts of Chinese lobelia herb, 5-15 parts of hedyotis diffusa, 5-15 parts of dandelion, 5-15 parts of fried rice sprout, 5-15 parts of roasted malt, 1-3 parts of fructus amomi, 2-4 parts of costus root and 0.5-1.5 parts of pseudo-ginseng.
Preferably, the traditional Chinese medicine composition for treating chronic atrophic gastritis is mainly prepared from the following raw materials in parts by weight: 10 parts of roasted astragalus root, 5 parts of dangshen, 5 parts of bighead atractylodes rhizome, 3 parts of dried orange peel, 5 parts of barbed skullcap herb, 10 parts of hedyotis diffusa, 10 parts of dandelion, 10 parts of fried rice sprout, 10 parts of roasted malt, 2 parts of fructus amomi, 3 parts of costus root and 1 part of pseudo-ginseng.
The Chinese medicinal composition comprises the following components:
in the traditional Chinese medicine composition, the monarch drugs comprise astragalus, dangshen, bighead atractylodes rhizome and dried orange peel to tonify qi and invigorate spleen.
Huang Qi is sweet in flavor and slightly warm in nature. Enters the lung and spleen meridians. The preparation method comprises the following steps: tonify middle energizer and replenish qi. For internal injury, fatigue, diarrhea due to spleen deficiency, rectocele, qi deficiency, blood loss, leucorrhea, and all qi and blood deficiency. Materia medica true: astragalus root, radix astragali, which is the most effective herb for tonifying qi, is called as "radix astragali". Materia medica preparation: the roasted medicine is used for tonifying middle energizer, invigorating primordial qi and strengthening spleen and stomach. Ben Cao Zhengyi (materia Medica): astragalus root, radix astragali, with the effects of invigorating middle-warmer and nourishing spleen and stomach, is suitable for those suffering from qi deficiency, spleen and soil weakness and sinking of qi.
Dang Shen is sweet in flavor and neutral in nature. Enter spleen and lung meridians. Has effects in invigorating spleen, tonifying lung, nourishing blood, and promoting salivation. Can be used for treating spleen and lung qi deficiency, anorexia, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid deficiency, and internal heat and diabetes. The materia medica is from new: tonify middle energizer and qi, harmonize spleen and stomach, and relieve polydipsia. Ben Cao Zhengyi (materia Medica): the dangshen has the effects of tonifying spleen and stomach, moistening lung and promoting fluid production, and strengthening middle energizer, and is not far from ginseng.
Bai Zhu is bitter and sweet in flavor and warm in nature. Enter spleen and stomach meridians. Has effects in invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, stopping sweating, and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and fetal movement. Medical Start Source (S): removing dampness, invigorating dryness, regulating stomach, invigorating qi, warming spleen and stomach, removing dampness in spleen and stomach, removing stomach heat, strengthening spleen and stomach, promoting digestion, regulating stomach, promoting body fluid production, activating muscle heat, drowsiness of limbs, no desire to open eyes, idle and limp sleeping, anorexia, quenching thirst, and miscarriage prevention. Materia medica true: what is the bighead atractylodes rhizome for tonifying spleen qi? Cover with spleen bitter and wet, eat bitter and dry, spleen desire slow, eat sweet and slow; bai Zhu is bitter and sweet in flavor, and can dry dampness and invigorate spleen, restore spleen and promote fluid production. It is warm in nature and can be taken as the first key herb for spleen qi-tonifying by tonifying food and removing food grains.
Chen Pi is bitter and pungent in flavor and warm in nature. Enter lung and spleen meridians. Has effects in regulating qi-flowing, invigorating spleen, eliminating dampness, and eliminating phlegm. Can be used for treating abdominal distention, anorexia, vomiting and diarrhea, cough with excessive phlegm. Materia medica Hui Yan: xin Shansan, so it can open the air; bitter stomach can promote the circulation of phlegm; it is good at regulating qi and can stop vomiting, relieve cough, invigorate spleen and harmonize stomach. East wall is: the spleen and stomach are the main aspects of the lady, and the disease treatment is first to regulate qi, for instance, the spleen is reinforced by the action of orange peel.
The four above four drugs are used as monarch drugs for tonifying qi and strengthening spleen.
In the traditional Chinese medicine composition, ministerial drugs are herba scutellariae barbatae, oldenlandia diffusa and dandelion, so as to clear away heat and toxic materials.
The ban Zhi Lian is pungent in flavor, neutral in nature and nontoxic. It enters lung, liver and kidney meridians. Has effects in clearing away heat and toxic materials, dispelling blood stasis, stopping bleeding, and relieving pain. It can be used for treating hematemesis, epistaxis, stranguria with blood, dysentery, jaundice, laryngopharynx pain, pulmonary abscess, furuncle, scrofula, skin sore, cancer, traumatic injury, incised wound, and snake bite. Guangzhou army's manual of Chinese herbal medicine in common use: clear away heat and toxic materials. The composition has effect in improving symptoms. Chengdu, handbook of common herbal medicine treatment: can be used for treating esophageal carcinoma, gastric cancer, and carcinoma of uterus.
Hedyotidis Diffusae is bitter, sweet, cold in nature and nontoxic. Enter heart, liver and spleen meridians. Has effects in clearing away heat, promoting diuresis, and removing toxic substances. It can be used for treating cough and asthma due to lung heat, tonsillitis, pharyngolaryngitis, pelvic inflammatory disease, adnexitis, appendicitis, dysentery, hepatitis, carbuncle, furuncle, and snake bite. Modern research: (1) antitumor: has strong inhibition effect on immune lymphocyte, granulocyte type, monocyte type and chronic granulocyte type tumor cells. (2) Antibacterial and anti-inflammatory effects: has effects in stimulating reticuloendothelial system proliferation and enhancing phagocyte activity, and has killing effect on Staphylococcus aureus and Bacillus dysenteriae.
Dandelion is bitter and sweet in flavor, cold in nature and nontoxic. Enters the liver and stomach meridians. Has effects in clearing away heat and toxic materials, promoting urination, and resolving hard mass. Can be used for treating acute mastitis, lymphadenitis, scrofula, furuncle, conjunctivitis, common cold, fever, acute tonsillitis, bronchitis, hepatitis, cholecystitis, pancreatitis, chronic gastritis, and gastric ulcer. New formulation of materia medica: dandelion is basic and powerful, and is unknown by the world. The Xuang has the following characteristics: for the sweet and neutral nature, it is used with Bai Hu Tang to purge fire and not hurt stomach qi in order to consolidate yang and improve fire. Excessive fire in the stomach is covered, and it is enough that the stomach is also in the form of soil decline, fire is discharged and soil is weakened. So it is very good at purging stomach fire from Hu Tang, but not in the long term. Dandelion also purges stomach fire, but its qi is very flat, so it can purge fire without losing soil, and it can be taken for a long time without obstruction. For the onset of yang-clear fire, it is often taken with large dosage, with the fire going back and stomach-qi being self-generated. However, it has little effect of purging fire, and it is multipurpose, one or two, five or six less, and can dispel pathogenic factors and assist healthy ear. Or ask dandelion to purge fire, check diarrhea and open fire, and do not recognize fire of each channel, can eliminate fire as much as possible? The following steps: in the most severe cases, the flame of yangming is absent, the flame of yangming is reduced, and the remaining fire is not consumed. Dandelion is not the herb of each meridian, but the fire of each meridian is the most general one, i.e. Dandelion can dispel the fire of each meridian.
The three medicines of the Chinese lobelia, the oldenlandia diffusa and the dandelion are used as ministerial medicines for clearing heat and detoxicating.
In the traditional Chinese medicine composition, the adjuvant drugs are fried rice sprout, fried malt, fructus amomi and costus root, so as to invigorate the spleen and promote appetite.
The stir-baked rice sprouts are sweet in flavor and warm in nature. Enter spleen and stomach meridians. Has effects in promoting digestion, regulating stomach function, invigorating spleen, and stimulating appetite. Can be used for treating dyspepsia, abdominal distention, halitosis, spleen and stomach weakness, and inappetence. The fried rice sprouts are used for promoting digestion and preventing hunger and anorexia. The focal rice sprouts are good at resolving accumulation and stagnation, and are indicated for accumulation and stagnation. Compendium of materia Medica: promoting appetite, descending qi, regulating middle warmer, promoting digestion, and resolving food stagnation.
Roasted malt is sweet in flavor and neutral in nature. Enter spleen and stomach meridians. Has effects in promoting qi circulation, resolving food stagnation, invigorating spleen, stimulating appetite, promoting lactation, and relieving distention. Can be used for treating dyspepsia, abdominal distention and pain, spleen deficiency, anorexia, galactostasis, breast pain, female galactostasis, liver Yu Xie pain, and liver and stomach qi pain. Modern researches have found that the product contains alpha and beta amylase. And starch is a mixture of sugar starch and gum starch. The glucose molecules that make up the sugar starch are linked by alpha-1, 4 glycosidic linkages and are in a linear arrangement. The gum starch is formed by a plurality of short linear chain polyglucans which are arranged in a crossed way. The amylopectin molecule has alpha-1, 6-glycoside bonds in addition to alpha-1, 4-glycoside bonds. Alpha and beta amylase can hydrolyze alpha-1, 4 glycoside bond, and has no effect on alpha-1, 6 glycoside bond. Beta amylase is able to hydrolyze the sugar starch completely to maltose, and alpha amylase breaks down it to short direct bond polyglucose (i.e. dextrins), which in turn are hydrolyzed by beta amylase to maltose. Starch is thus broken down into maltose and dextrins by the action of alpha and beta amylase enzymes. Malt decoction has slight promotion effect on gastric acid and pepsin secretion. For chronic atrophic gastritis, pepsin is reduced, so malt can be used for treatment.
Sha ren is pungent and warm in nature. Enters the spleen and stomach meridians. Can promote qi and regulate middle energizer, and harmonize stomach and invigorate spleen. For abdominal pain, distention, gastric stasis, dysphagia, vomiting, cold diarrhea, cold dysentery, fetal movement in pregnancy. Materia medica Hui Yan: herbs that warm middle energizer and regulate qi also. If the qi stem of the upper energizer is reversed but not downward, the qi of the lower energizer is suppressed but not upward, the qi of the middle energizer is coagulated and not comfortable, and the effect is most effective when the fructus amomi is used. Materia medica true: fructus Amomi is an essential herb for activating spleen and regulating stomach.
The smell of wood is pungent, bitter and warm. Enter the lung, liver and spleen meridians. Can promote qi circulation to relieve pain, warm the middle-jiao and regulate the stomach. For middle-jiao and qi stagnation, chest and epigastric distending pain, vomiting, diarrhea, dysentery with tenesmus. Medicine formation sense: bang Xiang is a key herb for regulating qi because it can ventilate and coordinate five zang organs. Ben Cao Zhengyi (materia Medica): near people are better in nourishing medicine, terrible and greasy and heavy stagnation, suffocation but not flexible, and when the medicine is added to dredge qi, the medicine is fast in operation and digestion and healthy, and is also good in assisting and guiding the people.
The four medicines are used as adjuvant medicines for activating spleen and stimulating appetite.
In the traditional Chinese medicine composition, the traditional Chinese medicine is pseudo-ginseng, so as to promote blood circulation and remove blood stasis.
Notoginseng radix has sweet taste, slightly bitter taste, warm nature, and no toxicity. Enters the liver, stomach and large intestine meridians. Can stop bleeding, remove blood stasis, reduce swelling and relieve pain. For hematemesis, hemoptysis, epistaxis, hematochezia, bloody dysentery, metrorrhagia, abdominal mass, postpartum anemic fainting, lochia, traumatic blood stasis, traumatic hemorrhage, carbuncle, swelling and ulcer. Medicine solution of Yu Zhong (Jade Song): and ying and stopping bleeding, promoting blood circulation and removing blood stasis, and astringing new blood. All blood stasis is broken after delivery, menstrual period, traumatic injury and carbuncle; all kinds of new blood can be treated by vomiting and epistaxis, metrorrhagia and metrostaxis, incised wound and arrow shooting. In the new book of herbal, sanchi root, radix Notoginseng, a drug for stopping bleeding, is used singly for all cases of blood in the upper, middle and lower regions, and is added to blood-replenishing and qi-tonifying herbs. The cover can stop the medicine without boiling, and the medicine can stop the medicine without quieting.
Notoginseng radix has the effect of promoting blood circulation and removing blood stasis, and is used as a guiding drug.
Atrophic gastritis is a chronic disease caused by the damage of gastric mucosa for a long time, and the pathogenesis is as follows: early exogenous pathogenic factors (including helicobacter pylori) invade the body, and the pathogenic factors are relatively strong and struggle with each other; in the middle stage, pathogenic factors are corrected, and pathogenic factors enter the stomach collaterals and healthy qi is also increased gradually; in the later stage, pathogenic factors are in quadrature, vital qi deficiency and pathogenic factors are loved, toxic heat and blood stasis are mutually combined, transportation and transformation are blocked, and at the moment, the situation of mucosal atrophy can be found in gastroscopy. Therefore, atrophic gastritis usually occurs in the late stage of stomach diseases, and is characterized by the accumulation of toxic heat and stasis due to lingering pathogenic factors of the vital energy. In terms of therapeutic method selection, therapeutic methods of replenishing qi to invigorate the spleen, clearing away toxic materials, removing blood stasis, harmonizing the stomach and promoting digestion should be adopted.
In the traditional Chinese medicine composition, astragalus, dangshen, bighead atractylodes rhizome, dried orange peel and the like are used for tonifying qi and strengthening spleen; clearing away heat and toxic materials from herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, etc.; the cereal sprout, rice sprout, fructus Amomi, radix aucklandiae, and the like are used for activating spleen and stimulating appetite. Notoginseng radix is used for removing blood stasis and promoting blood circulation; clinical shows that the prescription can take effect for about half a year, and the atrophic gastritis of the effective population can be reversed by rechecking the gastroscope for half a year to one year.
The traditional Chinese medicine composition can be prepared into a traditional Chinese medicine preparation by adopting a conventional method of a traditional Chinese medicine preparation, for example, raw material medicines are decocted in water or extracted by an alcohol-water mixture, then concentrated and dried decoction or extract is prepared into dry extract powder, the extract powder and medicines are added with proper auxiliary materials, and the traditional Chinese medicine preparation is prepared into a traditional Chinese medicine preparation by adopting a conventional pharmaceutical method of a person skilled in the art, wherein the traditional Chinese medicine preparation comprises tablets, granules, oral liquid and the like.
The Chinese medicinal composition is prepared into Chinese medicinal oral preparations.
In another aspect of the present invention, there is provided a method for preparing the Chinese medicinal composition, comprising the steps of:
firstly, decocting radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus and Notoginseng radix in water for 3 times;
and in the second step, fructus amomi and costus root in the raw materials are added for decoction and extraction.
Preferably, in the first step, the extracting with water for 3 times specifically comprises: 1500ml of water is added in the first decoction, the decoction time is 60 minutes, 150ml of residual juice is taken, 1000ml of water is added in the second decoction, the decoction time is 45 minutes, 1000ml of water is added in the third decoction, and the decoction time is 40 minutes.
Preferably, in the second step, the fructus amomi and costus root added into the raw material medicines are decocted for 5min, and 150ml of residual juice is obtained.
The beneficial effects of the invention are as follows: according to the pathogenesis characteristics of the chronic atrophic gastritis, the invention provides a traditional Chinese medicine formula with obvious curative effect and no toxic or side effect aiming at the deficiency of healthy qi and internal stagnation of toxin stasis, and the traditional Chinese medicine formula has the effects of tonifying qi and strengthening spleen, clearing heat and detoxicating, activating spleen and stomach, and activating blood and dissolving stasis. Radix astragali, radix Codonopsis, atractylodis rhizoma and pericarpium Citri Tangerinae are used as the principal ingredients, and are mainly used for strengthening the healthy qi, exciting the middle-jiao soil, gradually recovering the spleen and stomach functions, and consolidating the constitution. The Chinese lobelia, the oldenlandia diffusa and the dandelion have the effects of clearing away heat and toxic materials, and can be used as ministerial drugs for eliminating toxin evil and clearing residual toxin. The stir-fried rice sprout, the stir-fried malt, the fructus amomi, the elecampane, the spleen and stomach activating, the qi-attenuating, the smooth and rapid use, the normal operation recovering, and the auxiliary functions. Pseudo-ginseng has the effects of promoting blood circulation to remove blood stasis, removing blood stasis and toxic materials, causing the chronic diseases to become stasis, causing the healthy qi to be increasingly damaged due to deficiency and the pathogenic factors to be increasingly blocked, and the normal digestion function is paralysis, and plays a key role in strengthening the body resistance and eliminating the pathogenic factors due to the effects of promoting blood circulation to remove blood stasis and stirring up disorder, so that the pseudo-ginseng is particularly suitable for patients with chronic atrophic gastritis or atypical hyperplasia. Clinical experiments prove that the effective rate of the treatment group (the traditional Chinese medicine composition) for treating the chronic atrophic gastritis is 96.43% under gastroscope, which is far more than 76% of the effective rate of a control group adopting folic acid combined with gastric rejuvenation, the components of the traditional Chinese medicine composition have synergistic effect, and unexpected treatment effect in the field is achieved.
Detailed Description
The present invention is described below with reference to specific embodiments, and unless otherwise specified, all technical methods related to the present invention are those conventionally used by those skilled in the art, and therefore will not be described in detail.
EXAMPLE 1 preparation of the pharmaceutical formulation of the invention (Water decoction)
10 parts of roasted astragalus root (30 g), 5 parts of pilose asiabell root (15 g), 5 parts of largehead atractylodes rhizome (15 g), 3 parts of dried orange peel (9 g), 5 parts of Chinese lobelia (15 g), 10 parts of common hedyotis herb (30 g), 10 parts of dandelion (30 g), 10 parts of fried rice sprout (30 g), 10 parts of roasted malt (30 g), 2 parts of fructus amomi (5 g), 3 parts of costus root (10 g) and 1 part of sanchi (3 g)
Decocting radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus, and Notoginseng radix with water for 3 times, adding 1500ml of water for the first time, decocting for 60min, collecting 150ml of the rest juice, adding 1000ml of water for the second time, decocting for 45 min, adding 1000ml of water for the third time, decocting for 40 min, adding fructus Amomi and radix aucklandiae, decocting for 5min, collecting 150ml of the rest juice, and orally administering for two times each time for 150ml.
EXAMPLE 2 preparation of the pharmaceutical formulation of the invention (Water decoction)
5 parts of roasted astragalus root (15 g), 4 parts of pilose asiabell root (12 g), 4 parts of largehead atractylodes rhizome (12 g), 2 parts of dried orange peel (6 g), 4 parts of Chinese lobelia (12 g), 5 parts of common hedyotis herb (15 g), 5 parts of dandelion (15 g), 5 parts of fried rice sprout (15 g), 5 parts of roasted malt (15 g), 1 part of fructus amomi (3 g), 2 parts of costus root (6 g) and 0.5 part of pseudo-ginseng (1.5 g)
Decocting radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus, and Notoginseng radix with water for 3 times, adding 1500ml of water for the first time, decocting for 60min, collecting 150ml of the rest juice, adding 1000ml of water for the second time, decocting for 45 min, adding 1000ml of water for the third time, decocting for 40 min, adding fructus Amomi and radix aucklandiae, decocting for 5min, collecting 150ml of the rest juice, and orally administering for two times each time for 150ml.
EXAMPLE 3 preparation of the pharmaceutical formulation of the invention (Water decoction)
15 parts of roasted astragalus root (45 g), 6 parts of pilose asiabell root (18 g), 6 parts of largehead atractylodes rhizome (18 g), 4 parts of dried orange peel (12 g), 6 parts of Chinese lobelia (18 g), 15 parts of common hedyotis herb (45 g), 15 parts of dandelion (45 g), 15 parts of fried rice sprout (45 g), 15 parts of roasted malt (45 g), 3 parts of fructus amomi (9 g), 4 parts of costus root (12 g) and 1.5 parts of sanchi (4.5 g)
Decocting radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus, and Notoginseng radix with water for 3 times, adding 1500ml of water for the first time, decocting for 60min, collecting 150ml of the rest juice, adding 1000ml of water for the second time, decocting for 45 min, adding 1000ml of water for the third time, decocting for 40 min, adding fructus Amomi and radix aucklandiae, decocting for 5min, collecting 150ml of the rest juice, and orally administering for two times each time for 150ml.
EXAMPLE 4 preparation of pharmaceutical formulations (granules)
10 parts of roasted astragalus root (400 g), 5 parts of pilose asiabell root (200 g), 5 parts of largehead atractylodes rhizome (200 g), 3 parts of dried orange peel (120 g), 5 parts of Chinese lobelia (200 g), 10 parts of common hedyotis herb (400 g), 10 parts of dandelion (400 g), 10 parts of fried rice sprout (400 g), 10 parts of roasted malt (400 g), 2 parts of fructus amomi (80 g) 5g, 3 parts of costus root (120 g) and 1 part of sanchi (40 g)
Weighing radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus and Notoginseng radix according to the above formula, decocting with 10 times of water, slightly boiling for 60min, filtering, adding 8 times of water into the residue, slightly boiling for 60min, and filtering. Mixing the two decoctions, adding fructus Amomi and radix aucklandiae, decocting for 5min, filtering out the decoction, concentrating under reduced pressure to relative density of 1.25-1.30, spraying dextrin as base material, granulating in fluidized bed, and making into 1000g, packaging, 10g per bag, 2 times per day, and 2 bags per time.
EXAMPLE 5 preparation of the pharmaceutical formulation of the invention (tablet)
10 parts of roasted astragalus root (300 g), 5 parts of pilose asiabell root (150 g), 5 parts of largehead atractylodes rhizome (150 g), 3 parts of dried orange peel (90 g), 5 parts of Chinese lobelia (150 g), 10 parts of common hedyotis herb (300 g), 10 parts of dandelion (300 g), 10 parts of fried rice sprout (300 g), 10 parts of roasted malt (300 g), 2 parts of fructus amomi (60 g) 5g, 3 parts of costus root (90 g) and 1 part of sanchi (30 g)
Weighing radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus and Notoginseng radix according to the above formula, decocting with 10 times of water, slightly boiling for 60min, filtering, adding 10 times of water into the residues, slightly boiling for 30min, and filtering. Mixing the two decoctions, adding fructus Amomi and radix aucklandiae, decocting for 5min, filtering out the decoction, concentrating under reduced pressure, drying, adding dextrin and magnesium stearate into the extract powder, mixing, granulating, drying at 80deg.C, tabletting to obtain tablets each of 0.5 g, and orally administering for 3 times per day, 5 tablets each time.
EXAMPLE 6 preparation of the pharmaceutical formulation of the invention (Capsule)
10 parts of roasted astragalus root (300 g), 5 parts of pilose asiabell root (150 g), 5 parts of largehead atractylodes rhizome (150 g), 3 parts of dried orange peel (90 g), 5 parts of Chinese lobelia (150 g), 10 parts of common hedyotis herb (300 g), 10 parts of dandelion (300 g), 10 parts of fried rice sprout (300 g), 10 parts of roasted malt (300 g), 2 parts of fructus amomi (60 g) 5g, 3 parts of costus root (90 g) and 1 part of sanchi (30 g)
Weighing radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus and Notoginseng radix according to the above formula, decocting with 10 times of water, slightly boiling for 60min, filtering, adding 10 times of water into the residues, slightly boiling for 30min, and filtering. Mixing the two decoctions, adding fructus Amomi and radix aucklandiae, decocting for 5min, filtering out the decoction, concentrating under reduced pressure, drying, adding appropriate amount of dextrin and magnesium stearate into the extract powder, mixing, granulating, making into 1000g, adding appropriate amount of micropowder silica gel, mixing, encapsulating, and making into capsule, each dose of 0.4 g, and orally administering for 3 times per day, each dose of 5 granules.
The beneficial effects of the invention are further illustrated by clinical studies as follows:
the effect of the traditional Chinese medicine composition on the chronic atrophic gastritis is proved by clinical experiments of traditional Chinese medicine, 60 cases are collected according to diagnosis standards, exclusion standards and case rejection standards, 3 cases are dropped, 2 cases are rejected after inclusion because a pathological report does not accord with the standards, and 2 cases are withdrawn after inclusion because of personal reasons. Finally, 53 cases were successfully collected, wherein 28 patients in the treatment group adopting the traditional Chinese medicine composition provided by the invention were 25 patients in the control group adopting folic acid combined with Weifuchun, and the treatment course was 6 months.
The basic cases of the treatment group and control group cases are shown in tables 1-3. The differences after statistical treatment have no statistical significance (P > 0.05), and are comparable.
Table 1 two sets of sex distribution tables (Unit: person)
Table 2 two age references (X.+ -. S)
Table 3 two sets of gastroscope diagnostic grading comparison tables (Unit: person)
The treatment results were as follows:
the gastroscope was reviewed 6 months after treatment, recovery after gastric mucosal treatment was diagnosed with more than 2 endoscopes, and after rank sum test calculation, z=3.609, p=0.000, the disease distribution was significantly different after both groups of treatments, and the results were statistically significant (P < 0.05), see table 4.
TABLE 4 gastroscope diagnostic distribution table (Unit: person) after treatment
| Group of | The number of people | Non-atrophy | Mild and mild | Moderate degree | Heavy weight |
| Treatment group | 28 | 16(57.14％) | 11(39.29％) | 1(3.57％) | 0(0％) |
| Control group | 25 | 3(12％) | 16(64％) | 5(20％) | 1(4％) |
After treatment, the observed group has significant differences in the distribution of efficacy under gastroscope compared with the control group, z= -4.012, p=0.000, p <0.05, see table 5.
Table 5 gastroscope efficacy graduation comparison (Unit: person)
| Group of | The number of people | Healing of the wound | Has obvious effect | Effective and effective | Invalidation of |
| Treatment group | 28 | 14(50％) | 9(32.14％) | 4(14.29％) | 1(3.57％) |
| Control group | 25 | 3(12％) | 3(12％) | 13(52％) | 6(24％) |
As shown in Table 5, the effective rate of the traditional Chinese medicine composition for treating chronic atrophic gastritis is 96.43% under gastroscope, which is far more than 76% of the effective rate of a control group adopting folic acid combined with gastric rejuvenation, and the unexpected treatment effect in the field is achieved.
The foregoing is only a preferred embodiment of the invention, it being noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the present invention, and such modifications and adaptations are intended to be comprehended within the scope of the invention.
Claims (6)
1. The traditional Chinese medicine composition for treating the chronic atrophic gastritis is characterized by being mainly prepared from the following raw materials in parts by weight: 5-15 parts of roasted astragalus root, 4-6 parts of dangshen, 4-6 parts of bighead atractylodes rhizome, 2-4 parts of dried orange peel, 4-6 parts of Chinese lobelia herb, 5-15 parts of hedyotis diffusa, 5-15 parts of dandelion, 5-15 parts of fried rice sprout, 5-15 parts of roasted malt, 1-3 parts of fructus amomi, 2-4 parts of costus root and 0.5-1.5 parts of pseudo-ginseng.
2. The traditional Chinese medicine composition according to claim 1, which is mainly prepared from the following raw materials in parts by weight: 10 parts of roasted astragalus root, 5 parts of dangshen, 5 parts of bighead atractylodes rhizome, 3 parts of dried orange peel, 5 parts of barbed skullcap herb, 10 parts of hedyotis diffusa, 10 parts of dandelion, 10 parts of fried rice sprout, 10 parts of roasted malt, 2 parts of fructus amomi, 3 parts of costus root and 1 part of pseudo-ginseng.
3. The traditional Chinese medicine composition according to any one of claims 1-2, wherein the traditional Chinese medicine composition is prepared into a traditional Chinese medicine oral preparation.
4. A method for preparing a Chinese medicinal composition according to any one of claims 1 to 3, comprising the steps of:
firstly, decocting radix astragali Preparata, radix Codonopsis, atractylodis rhizoma, pericarpium Citri Tangerinae, herba Scutellariae Barbatae, herba Hedyotidis Diffusae, herba Taraxaci, parched fructus Setariae Germinatus, parched fructus Hordei Germinatus and Notoginseng radix in water for 3 times;
and in the second step, fructus amomi and costus root in the raw materials are added for decoction and extraction.
5. The method of claim 4, wherein in the first step, the extracting with water for 3 times is specifically: 1500ml of water is added in the first decoction, the decoction time is 60 minutes, 150ml of residual juice is taken, 1000ml of water is added in the second decoction, the decoction time is 45 minutes, 1000ml of water is added in the third decoction, and the decoction time is 40 minutes.
6. The preparation method according to claim 4, wherein in the second step, fructus Amomi and radix aucklandiae added into the raw materials are decocted for 5min, and 150ml of the residual juice is obtained.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150908A (en) * | 1995-11-18 | 1997-06-04 | 张安喜 | Preparation of medicine for treating atrophic gastritis |
| CN104056178A (en) * | 2014-07-10 | 2014-09-24 | 海南医学院 | Traditional Chinese medicine combination with digestion-improving function and application thereof |
| CN104474441A (en) * | 2014-11-27 | 2015-04-01 | 张雷 | Drug for treating gastropathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150908A (en) * | 1995-11-18 | 1997-06-04 | 张安喜 | Preparation of medicine for treating atrophic gastritis |
| CN104056178A (en) * | 2014-07-10 | 2014-09-24 | 海南医学院 | Traditional Chinese medicine combination with digestion-improving function and application thereof |
| CN104474441A (en) * | 2014-11-27 | 2015-04-01 | 张雷 | Drug for treating gastropathy |
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| Title |
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| 何勤泉 等: "益气活血汤加减治疗慢性萎缩性胃炎56例", 四川中医, vol. 29, no. 9, pages 57 - 58 * |
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