CN105832991B - Traditional Chinese medicine composition for treating gastritis - Google Patents
Traditional Chinese medicine composition for treating gastritis Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating gastritis, which comprises the following raw materials in parts by weight: 5-20 parts of radix bupleuri, 5-20 parts of fructus aurantii, 5-30 parts of radix paeoniae alba, 5-20 parts of rhizoma cyperi, 5-20 parts of raw liquorice, 5-20 parts of honey-fried licorice root, 5-20 parts of cuttlebone, 5-20 parts of thunberg fritillary bulb, 5-20 parts of dandelion, 3-30 parts of coptis chinensis, 1-10 parts of fructus evodiae and 5-20 parts of herba eupatorii. The raw materials of the traditional Chinese medicine composition can also comprise one or more of scutellaria baicalensis, rhizoma pinellinae praeparata, poria cocos, scorched medicated leaven, scorched hawthorn fruit, scorched malt, agastache rugosus, bulbus fritillariae cirrhosae and rhizoma galangae. The traditional Chinese medicine composition has definite curative effect on acute gastritis and chronic gastritis caused by various reasons.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition with an exact curative effect on gastritis.
Background
Gastritis is one of the most common digestive disorders, often accompanied by epithelial damage, mucosal inflammatory reactions and epithelial regeneration. Gastritis is generally classified into acute gastritis and chronic gastritis according to the degree of urgency and the length of the clinical course. The former is acute gastric mucositis caused by multiple etiologies; clinically, it is usually manifested as epigastric discomfort, dull pain, nausea, vomiting, etc. Chronic gastritis is a chronic inflammation or atrophic lesion of the gastric mucosa caused by various causes, and is classified into superficial gastritis, atrophic gastritis, bile reflux gastritis, and the like. The disease has long history, is easy to repeatedly attack and is difficult to radically cure; clinically, it is manifested as epigastric pain, abdominal distention, belching, inappetence, acid regurgitation, asthenia, constipation or diarrhea, and even gastric mucosa degeneration and atrophy, and decreased gastric secretion function, which may lead to emaciation, decreased immunity and even gastric mucosa deterioration. The occurrence and development of chronic gastritis are closely related to emotion, stress and life style. With the accelerated pace of life and the increased pressure of life, the incidence of chronic gastritis is high, which greatly harms the health of people and increases the medical burden.
At present, gastric mucosa protective agents, antacids, gastrointestinal motility function regulators, antibiotics and other symptomatic treatment medicines are generally adopted clinically, and continuous medicine taking is needed for one to two months. Antacids are the most commonly used drugs, which, while alleviating the further irritation of gastric acid to the damaged gastric mucosa, relieve stomachache; but also reduces the digestive absorption of food in the stomach.
Gastritis, especially chronic gastritis belongs to the disease scope of traditional Chinese medicine ' epigastric pain ' and stomach stuffiness ' and the like. The traditional Chinese medicine considers that chronic gastritis causes various symptoms due to long-term emotional distress, improper diet and improper work and rest, liver qi stagnation, spleen dysfunction, gastric cavity disharmony and qi deficiency in middle-jiao for a long time. The traditional Chinese medicine has better effect on treating chronic gastritis. For example, the unprocessed rhizoma Pinelliae decoction for purging heart in Guochun was modified to treat 100 cases of chronic gastritis, and 50 cases of the control group were prepared with Xiangsha Liujunzi pills, and 1 month was 1 course of treatment. The results show that the effective rates of the treatment group and the control group are respectively 92% and 76% (P < 0.05) (Guo Chun Sheng, pinellia Tuber and Xixin Tang for treating chronic gastritis 100 cases of clinical observation [ J ]. national medical Forum, 2006, 21(5): 7).
Although a plurality of medicines which take gastritis, particularly various chronic gastritis as indication symptoms, including Chinese patent medicines, appear in the prior art, the incidence rate of the chronic gastritis in China is still up to 30% according to statistics, which shows that the existing medicines can not meet the clinical treatment requirements.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a traditional Chinese medicine composition with remarkable curative effect on gastritis, in particular to various chronic gastritis. For the pathogenesis of gastritis: the traditional Chinese medicine composition takes ' soothing liver, regulating qi ', strengthening spleen and harmonizing stomach ' as main treatment methods, has reasonable and essential formula, has exact curative effect on acute and chronic gastritis in clinical application, generally takes effect in 3-5 days, has obvious effect in 5-10 days, and has low recurrence rate.
In order to achieve the purpose of the invention, the invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating gastritis comprises the following raw materials in parts by weight:
5-20 parts of radix bupleuri, 5-20 parts of fructus aurantii, 5-30 parts of radix paeoniae alba, 5-20 parts of rhizoma cyperi, 5-20 parts of raw liquorice, 5-20 parts of honey-fried licorice root, 5-20 parts of cuttlebone, 5-20 parts of thunberg fritillary bulb, 5-20 parts of dandelion, 3-30 parts of coptis chinensis, 1-10 parts of fructus evodiae and 5-20 parts of herba eupatorii.
Preferably, the raw materials of the traditional Chinese medicine composition comprise the following medicinal materials in parts by weight:
10-20 parts of radix bupleuri, 10-20 parts of fructus aurantii, 10-30 parts of radix paeoniae alba, 10-20 parts of rhizoma cyperi, 10-20 parts of raw liquorice, 10-20 parts of honey-fried licorice root, 10-20 parts of cuttlebone, 10-20 parts of thunberg fritillary bulb, 10-20 parts of dandelion, 5-15 parts of coptis chinensis, 1-5 parts of fructus evodiae and 10-20 parts of herba eupatorii.
Preferably, the raw materials of the traditional Chinese medicine composition comprise fructus aurantii, rhizoma cyperi, raw liquorice, honey-fried licorice root, cuttlebone, thunberg fritillary bulb and dandelion in the same weight part.
Preferably, in the traditional Chinese medicine composition, the weight parts of the coptis chinensis and the evodia rutaecarpa in the raw materials are less than the weight parts of other medicinal materials; in particular, the weight portion of the fructus evodiae is minimum.
In order to enhance the curative effect, the raw materials of the traditional Chinese medicine composition also comprise one or more of scutellaria baicalensis, rhizoma pinellinae praeparata, poria cocos, charred medicated leaven, charred hawthorn, charred malt, agastache rugosus, bulbus fritilariae and galangal.
As a preferred embodiment, the present invention provides a traditional Chinese medicine composition for treating gastritis, which comprises the following raw materials:
5-20 parts of radix bupleuri, 5-20 parts of fructus aurantii, 5-30 parts of radix paeoniae alba, 5-20 parts of rhizoma cyperi, 5-20 parts of raw liquorice, 5-20 parts of honey-fried licorice root, 5-20 parts of cuttlebone, 5-20 parts of thunberg fritillary bulb, 5-20 parts of dandelion, 3-30 parts of coptis chinensis, 1-10 parts of fructus evodiae, 5-20 parts of herba eupatorii, 5-20 parts of scutellaria baicalensis, 5-20 parts of rhizoma pinellinae praeparata, 5-30 parts of poria cocos, 5-30 parts of burnt medicated leaven, 5-30 parts of burnt hawthorn, 5-30 parts of burnt malt, 5-20 parts of agastache rugosus, 3-15 parts of bulbus fritillariae cirrhosae and 3-15 parts of galangal.
As a more preferable embodiment, the present invention provides a traditional Chinese medicine composition for treating gastritis, which comprises the following raw materials:
10-20 parts of radix bupleuri, 10-20 parts of fructus aurantii, 10-30 parts of radix paeoniae alba, 10-20 parts of rhizoma cyperi, 10-20 parts of raw liquorice, 10-20 parts of honey-fried licorice root, 10-20 parts of cuttlebone, 10-20 parts of thunberg fritillary bulb, 10-20 parts of dandelion, 5-15 parts of coptis chinensis, 1-5 parts of fructus evodiae, 10-20 parts of herba eupatorii, 10-20 parts of scutellaria baicalensis, 9-20 parts of rhizoma pinellinae praeparata, 10-30 parts of poria cocos, 10-30 parts of burnt medicated leaven, 10-30 parts of burnt hawthorn, 10-30 parts of burnt malt, 10-30 parts of agastache rugosus, 5-15 parts of bulbus fritillariae cirrhosae and 5-15 parts of galangal.
The preferable Chinese medicinal composition comprises the same raw materials of fructus aurantii, rhizoma cyperi, raw liquorice, honey-fried licorice root, cuttlebone, thunberg fritillary bulb and dandelion in parts by weight.
In the preferable traditional Chinese medicine composition, the weight parts of the coptis chinensis, the evodia rutaecarpa, the bulbus fritilariae and the rhizoma pinellinae praeparata in the raw materials are less than the weight parts of other medicinal materials; in particular, the weight portion of the fructus evodiae is minimum.
As the most preferred embodiment, the traditional Chinese medicine composition for treating gastritis provided by the invention comprises the following raw materials:
10 parts of radix bupleuri, 10 parts of fructus aurantii, 15 parts of radix paeoniae alba, 10 parts of rhizoma cyperi, 10 parts of raw liquorice, 10 parts of honey-fried licorice root, 10 parts of cuttlebone, 10 parts of thunberg fritillary bulb, 10 parts of dandelion, 6 parts of coptis chinensis, 2 parts of fructus evodiae, 10 parts of herba eupatorii, 10 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 15 parts of poria cocos, 15 parts of charred medicated leaven, 15 parts of charred hawthorn, 15 parts of charred malt, 10 parts of agastache rugosus, 6 parts of bulbus fritillariae cirrhosae and 6 parts of galangal.
Another objective of the present invention is to provide a preparation method of the above-mentioned Chinese medicinal composition, comprising the following steps:
the raw materials in parts by weight are directly crushed or extracted by water or ethanol water solution, and are prepared into clinically acceptable preparations according to the conventional method in the field with or without pharmaceutically acceptable auxiliary materials.
The clinically acceptable preparation is preferably an oral preparation, more preferably a decoction, an oral liquid, a honey pill, a water pill, a concentrated pill, a capsule or a tablet.
The invention also provides a medicine prepared by the preparation method.
The invention also aims to provide application of the traditional Chinese medicine composition or the medicine prepared by the preparation method in preparing a medicine for treating gastritis.
The gastritis includes acute gastritis and chronic gastritis; the chronic gastritis includes superficial gastritis, chronic erosive gastritis and atrophic gastritis.
The weight parts of the traditional Chinese medicine composition indicate that the dosage and the proportion of all raw materials in the traditional Chinese medicine composition are related. The "1 part by weight" of the present invention may be "1 g", "1 kg" or any other weight according to practical use.
In the preparation method of the traditional Chinese medicine composition, if no special description is provided, the dosage of the water or ethanol water solution is the conventional dosage in the field.
The traditional Chinese medicine composition has exact curative effect on acute gastritis and chronic gastritis caused by various reasons, the symptoms of abdominal distension, abdominal pain, diarrhea, nausea, vomiting, hiccup, acid regurgitation and the like of a patient are obviously relieved after the traditional Chinese medicine composition is generally administered for 3 days, and the symptoms basically disappear after 5-10 days; and the physical signs of the patients before taking the medicine, such as yellow or dark yellow complexion, emaciation in physical form and the like, are also obviously improved, which shows that the functions of the spleen and the stomach for transporting and transforming food essence are recovered, and the organism can be nourished, thereby improving the physique of the patients.
Detailed Description
The invention is further illustrated with reference to specific examples. It will be understood by those skilled in the art that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention in any way. The experimental procedures in the following examples are conventional unless otherwise specified. The raw materials and reagents used in the following examples are all commercially available products unless otherwise specified.
Example 1Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: g; 1g ═ 1 part by weight)
10 parts of radix bupleuri, 10 parts of fructus aurantii, 15 parts of radix paeoniae alba, 10 parts of rhizoma cyperi, 10 parts of raw liquorice, 10 parts of honey-fried licorice root, 10 parts of cuttlebone, 10 parts of thunberg fritillary bulb, 10 parts of dandelion, 6 parts of coptis chinensis, 2 parts of fructus evodiae and 10 parts of herba eupatorii.
Example 2Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: g; 1g ═ 1 part by weight)
20 parts of radix bupleuri, 15 parts of fructus aurantii, 20 parts of radix paeoniae alba, 15 parts of rhizoma cyperi, 15 parts of raw liquorice, 15 parts of honey-fried licorice root, 15 parts of cuttlebone, 15 parts of thunberg fritillary bulb, 15 parts of dandelion, 10 parts of coptis chinensis, 5 parts of fructus evodiae and 20 parts of herba eupatorii.
Example 3Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: g; 10g ═ 1 part by weight)
50 parts of radix bupleuri, 50 parts of fructus aurantii, 100 parts of radix paeoniae alba, 50 parts of rhizoma cyperi, 50 parts of raw liquorice, 50 parts of honey-fried licorice root, 50 parts of cuttlebone, 50 parts of thunberg fritillary bulb, 50 parts of dandelion, 50 parts of coptis chinensis, 10 parts of fructus evodiae and 100 parts of herba eupatorii.
Example 4Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: kg; 1kg ═ 1 part by weight)
20 parts of radix bupleuri, 10 parts of fructus aurantii, 15 parts of radix paeoniae alba, 10 parts of rhizoma cyperi, 10 parts of raw liquorice, 10 parts of honey-fried licorice root, 10 parts of cuttlebone, 10 parts of thunberg fritillary bulb, 10 parts of dandelion, 9 parts of coptis chinensis, 3 parts of fructus evodiae and 10 parts of herba eupatorii.
Example 5Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: g; 1g ═ 1 part by weight)
10 parts of radix bupleuri, 10 parts of fructus aurantii, 15 parts of radix paeoniae alba, 10 parts of rhizoma cyperi, 10 parts of raw liquorice, 10 parts of honey-fried licorice root, 10 parts of cuttlebone, 10 parts of thunberg fritillary bulb, 10 parts of dandelion, 10 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 6 parts of coptis chinensis, 2 parts of fructus evodiae, 15 parts of poria cocos, 10 parts of eupatorium, 15 parts of charred medicated leaven, 15 parts of charred hawthorn, 15.
Example 6Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: g; 1g ═ 1 part by weight)
15 parts of radix bupleuri, 15 parts of fructus aurantii, 20 parts of radix paeoniae alba, 15 parts of rhizoma cyperi, 15 parts of raw liquorice, 15 parts of honey-fried licorice root, 15 parts of cuttlebone, 15 parts of thunberg fritillary bulb, 15 parts of dandelion, 10 parts of radix scutellariae, 6 parts of rhizoma pinellinae praeparata, 6 parts of coptis chinensis, 2 parts of fructus evodiae, 10 parts of charred medicated leaven, 10 parts of charred hawthorn, 10 parts of.
Example 7Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: g; 1g ═ 1 part by weight)
20 parts of radix bupleuri, 10 parts of fructus aurantii, 15 parts of radix paeoniae alba, 10 parts of rhizoma cyperi, 10 parts of raw liquorice, 10 parts of honey-fried licorice root, 10 parts of cuttlebone, 10 parts of thunberg fritillary bulb, 10 parts of dandelion, 10 parts of scutellaria baicalensis, 9 parts of coptis chinensis, 2 parts of fructus evodiae, 10 parts of poria cocos, 10 parts of eupatorium, 15 parts of charred medicated leaven, 15 parts of charred hawthorn, 15 parts.
Example 8Traditional Chinese medicine composition for treating gastritis
The raw materials comprise: (unit: kg; 1kg ═ 1 part by weight)
20 parts of radix bupleuri, 15 parts of fructus aurantii, 30 parts of radix paeoniae alba, 15 parts of rhizoma cyperi, 15 parts of raw liquorice, 15 parts of honey-fried licorice root, 15 parts of cuttlebone, 15 parts of thunberg fritillary bulb, 15 parts of dandelion, 10 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 6 parts of coptis chinensis, 2 parts of fructus evodiae, 10 parts of poria cocos, 10 parts of eupatorium, 15 parts of charred medicated leaven, 15 parts of charred hawthorn, 15.
Example 9A Chinese medicinal composition (decoction) for treating gastritis
Preparing the medicinal materials according to the raw material composition of the embodiment 1, adding water, decocting for two times, each time for 30-40 minutes, wherein the amount of water used in each time is 5-8 times of the total weight of the medicinal materials, and combining the two decoctions to obtain the traditional Chinese medicine composition.
The usage method comprises the following steps: the liquid medicine is taken twice within one day.
Example 10A Chinese medicinal composition (decoction) for treating gastritis
Preparing the medicinal materials according to the raw material composition of the embodiment 5, adding water, decocting for two times, each time for 30-40 minutes, wherein the amount of water used in each time is 5-8 times of the total weight of the medicinal materials, and combining the two decoctions to obtain the traditional Chinese medicine composition.
The usage method comprises the following steps: the liquid medicine is taken twice within one day.
Example 11A Chinese medicinal composition (concentrated pill) for treating gastritis
Preparing the raw materials according to the composition of the raw materials in the example 8; respectively crushing cuttlebone, white paeony root, poria cocos, thunberg fritillary bulb and bulbus fritilariae and sieving the crushed materials with a 100-mesh sieve for later use; decocting other medicinal materials with water twice, each time for 60 minutes, wherein the dosage of water is 8-10 times of the total weight of the medicinal materials, and combining the two decoctions; concentrating the water decoction to obtain soft extract, adding Os Sepiae, Bulbus Fritillariae Thunbergii and Bulbus Fritillariae Cirrhosae powder, mixing, making into pill, and bottling to obtain 200 pills/bottle.
The usage method comprises the following steps: the traditional Chinese medicine composition is orally taken, 10-20 pills are taken once, and the traditional Chinese medicine composition is taken twice a day.
Example 12A Chinese medicinal composition (honeyed pill) for treating gastritis
Preparing the raw materials according to the raw material composition of the example 4, respectively crushing the raw materials, sieving the raw materials by a sieve of 80 meshes, uniformly mixing the raw materials, adding refined honey (the weight ratio of the medicinal powder to the refined honey is 1:1), and preparing into big honeyed pills with the dosage of 6g per pill.
The usage method comprises the following steps: orally taken, one pill once and twice a day.
Example 13A Chinese medicinal composition (tablet or capsule) for treating gastritis
Preparing each medicinal material according to the raw material composition of example 7 and a proportion of 1 part by weight to 1 kg; pulverizing Os Sepiae, and sieving with 100 mesh sieve; and heating and extracting the other medicines by using an ethanol solution with the volume percentage concentration of 50% for two times, wherein the dosage of the ethanol solution is 6-8 times of the total weight of the extracted medicinal materials each time for 1.5 hours, combining the extracting solutions obtained in two times, recovering ethanol, concentrating to obtain clear paste with the density of 1.2-1.4 g/ml at 60 ℃, adding cuttlebone powder, uniformly mixing, drying, crushing, adding a proper amount of starch, granulating, tabletting or encapsulating.
The usage method comprises the following steps: the capsules are taken twice a day, and 3-4 tablets or 3-4 capsules are taken each time.
Example 14A Chinese medicinal composition (oral liquid or syrup) for treating gastritis
Preparing each medicinal material according to the raw material composition of example 7 and a proportion of 1 part by weight to 1 kg; decocting with water for 2 times, each time for 1 hr, each time using 8 times of the total weight of the medicinal materials, and mixing the decoctions; adding ethanol until the ethanol concentration is 50%, standing, filtering to obtain supernatant, recovering ethanol until no ethanol smell exists, concentrating to obtain fluid extract with density of 1.2-1.4 g/ml at 60 ℃, adding taste masking agent, and making into oral liquid or syrup.
The dosage is 10ml twice a day.
Clinical observation example 1The invention relates to a Chinese medicamentClinical effects of composition in treating chronic gastritis
1. General data
100 chronic gastritis patients are randomly divided into 2 groups, 50 treatment groups and 50 control groups in the department of gastroenterology of Guangan department of Chinese science and science.
The age, sex, course of disease, etc. of the two groups of patients were not statistically different and were comparable.
2. Diagnostic criteria
Made according to the clinical research guiding principle of new traditional Chinese medicines of Ministry of health and the diagnostic curative effect standard of traditional Chinese medicine disease of State administration of traditional Chinese medicine.
The inclusion standard is that ① endoscopy meets the diagnosis standard of chronic gastritis, ② has the symptoms of epigastric pain, gastrectasia, acid regurgitation, anorexia, loose stool, hypodynamia and the like, white and greasy tongue coating and wiry pulse, and the course of the disease is more than 2 months.
The exclusion criteria are ① patients with red tongue with little coating or red tongue with yellow coating, ② patients with peptic ulcer or suspected malignant change, ③ patients with other serious systemic diseases, and ④ patients with complications which can affect the observation of curative effect or have contraindications to the tested drugs.
3. Standard of therapeutic effect
The scores of 0, 1, 2 and 3 are respectively recorded as 'none, light, medium and heavy', and the symptoms of epigastric pain, gastrectasia, acid regurgitation, anorexia, loose stool, hypodynamia and the like of the patient are respectively scored before and after treatment, and the total score is calculated. The total score reduction after treatment was calculated according to the following formula.
The ratio of total score reduction ═ (total score before treatment-total score after treatment)/total score before treatment × 100%
According to the total score reduction ratio and combined with the gastroscopy result, the curative effect is divided into near-term clinical cure, obvious effect, effective effect and ineffective effect:
the recent clinical cure is as follows: the total score of the clinical main symptoms is reduced by more than or equal to 75 percent after treatment, the active inflammation disappears in gastroscopy, the chronic inflammation improves, and the pathological examination proves that the gland atrophy seen in the gastroscopy returns to normal or disappears.
The effect is shown: 75% more than the total score of the clinical chief symptoms after treatment is reduced by more than or equal to 55%, the acute inflammation of mucosa basically disappears and the chronic inflammation is improved under the examination of gastroscope, and the gland atrophy and the intestinal metaplasia or atypical hyperplasia seen by the gastroscope are reduced through the verification of pathological examination.
The method has the following advantages: 55% more than the reduction ratio of the total score of the clinical main symptoms after treatment is more than or equal to 40%, the pathological change range of mucosa is reduced by 1/2% in gastroscopy, the inflammation is reduced, and pathological examination proves that the inflammation, gland atrophy and intestinal or atypical hyperplasia seen in the gastroscopy are reduced.
And (4) invalidation: the total score of the clinical chief symptoms after treatment is reduced by less than 40 percent, or the symptoms are worsened.
4. Method of treatment
Treatment groups: the Chinese medicinal composition prepared in example 10 is decocted with water, and is taken twice a day, 5 days is a treatment course, and the treatment course is one treatment course.
Control group: 10g of pinellia ternate, 10g of scutellaria baicalensis, 6g of coptis chinensis, 10g of rhizoma zingiberis, 15g of codonopsis pilosula, 6g of liquorice and 10g of Chinese date (pinellia ternate heart-fire-purging decoction); the decoction is prepared according to the method of example 10, and is taken twice a day, 5 days as a course of treatment, and one course of treatment.
5. Test results
During the treatment, no side effects were observed in both groups. The clinical efficacy of the treatment group and the control group is compared with each other, and the data are shown in Table 1.
TABLE 1 comparison of clinical efficacy of the treated and control groups
The indexes of the treatment group such as average score reduction ratio, cure rate, total effective rate and the like are obviously better than those of the control group, which shows that the traditional Chinese medicine composition has better treatment effect on chronic gastritis.
6. Typical cases
1) Treatment group
① board Limax, male, 48 years old, chronic erosive gastritis diagnosed by gastroscopy, 3 years of course, a course of treatment, reaching the near clinical cure, continuous administration for a course of treatment, greatly improved physical signs, and scoring of symptoms and physical signs before and after treatment, see Table 2.
TABLE 2 patient symptoms and signs scoring table (1)
② Du Yan, Ma, 37 years old, after gastroscopy diagnosis, chronic gastritis with course of 2.5 years, a course of treatment, reaching the near clinical cure, and a continuous course of treatment, greatly improving the signs, and scoring the symptoms and signs before and after treatment, see Table 3.
TABLE 3 patient symptoms and signs scoring table (2)
③ Lixx for male, 43 years old, diagnosis chronic gastritis by gastroscopy, course of disease of 1.5 years, treatment of a course of treatment, reaching recent clinical cure, continuous administration of a course of treatment, greatly improved physical signs, and scoring of symptoms and physical signs before and after treatment, see Table 4.
TABLE 4 patient symptoms and signs scoring table (3)
2) Control group
① piece xxx, male, 44 years old, diagnosed as chronic gastritis by gastroscopy, with a course of 2 years, after a course of treatment, the patient achieves the near clinical cure, and continuously takes medicine for a course of treatment, the physical signs are partially improved, and the scoring conditions of various symptoms and physical signs before and after the treatment are shown in Table 5.
TABLE 5 patient symptoms and signs scoring table (4)
② Zhang XXX, male, and 44 years old, the disease course is 1.5 years, after a course of treatment, the short clinical cure is reached, and the medicine is continuously taken for a course of treatment, the physical signs are partially improved, and the scoring conditions of various symptoms and physical signs before and after the treatment are shown in Table 6.
TABLE 6 patient symptoms and signs scoring table (5)
Clinical observation example 2The clinical effect of the traditional Chinese medicine composition on treating acute gastritis
80 patients with acute gastritis are treated by the decoction prepared in the example 10 in the department of gastroenterology of Guangan department of Chinese medical science and department of medicine, namely, 80 patients with acute gastritis who suffer from nausea, vomiting, epigastric pain and acute onset of diseases due to improper diet or acute attack of chronic gastritis, and gastrointestinal reactions caused by bacterial gastroenteritis and other diseases are excluded. The scores of 'none, light, medium and heavy' are respectively recorded as '0, 1, 2 and 3', the symptoms of abdominal pain, nausea, vomit, diarrhea, hypodynamia and the like of the patient are respectively scored before and after treatment, and the total score is calculated.
All patients have scores of 2-3 points before taking the medicine, and the total score is 12-15 points; after the medicine is taken for 3 days, the symptoms are obviously relieved, the scores of all the medicines are reduced to 1-2 points, and the total score is 4-9 points; after 5 days, the symptoms basically disappear, the scores of all the components are reduced to 0-1, and the total score is 0-2.
Through clinical medication observation of the patients, the traditional Chinese medicine composition has very obvious curative effect on acute gastritis.
Some representative cases are as follows:
1. if men are 50 years old with abdominal pain, nausea, vomiting, hypodynamia and diarrhea for 1 day, and bacterial gastroenteritis is excluded by feces examination, the decoction prepared in example 10 is administered, the symptoms are obviously relieved in 3 days, and the symptoms disappear in 5 days except slight nausea. The scores of the symptoms and signs are shown in Table 7.
TABLE 7 patient symptoms and signs scoring table (6)
| Symptoms and signs | Before treatment | The treatment lasts for 3 days | The treatment lasts for 5 days | Physical signs | Before treatment | The treatment lasts for 5 days | The treatment lasts for 10 days |
| Diarrhea (diarrhea) | 3 | 1 | 0 | Dark yellow complexion | 3 | 2 | 0 |
| Nausea | 3 | 2 | 1 | Dehydrated face mask | 3 | 1 | 0 |
| Vomiting | 3 | 1 | 0 | ||||
| Abdominal pain | 3 | 0 | 0 | ||||
| Total score | 12 | 4 | 1 | Total score | 6 | 3 | 0 |
2. Huang X, male, age 43, was examined for abdominal pain, nausea, vomiting, asthenia, diarrhea for 2 days, and bacterial gastroenteritis was excluded by stool examination, and the water decoction prepared in example 10 was administered to relieve the symptoms for 3 days and to eliminate the symptoms except slight abdominal pain in 5 days. The scoring of each symptom and sign is shown in table 8.
TABLE 8 patient symptoms and signs scoring table (7)
| Symptoms and signs | Before treatment | The treatment lasts for 3 days | The treatment lasts for 5 days | Physical signs | Before treatment | The treatment lasts for 5 days | The treatment lasts for 10 days |
| Diarrhea (diarrhea) | 3 | 2 | 0 | Yellow colour | 3 | 2 | 0 |
| Nausea | 3 | 2 | 0 | Dehydrated face mask | 3 | 2 | 0 |
| Vomiting | 3 | 1 | 0 | ||||
| Abdominal pain | 3 | 1 | 1 | ||||
| Total score | 12 | 6 | 1 | Total score | 6 | 4 | 0 |
Claims (9)
1. A traditional Chinese medicine composition for treating gastritis comprises the following raw materials:
10-20 parts of radix bupleuri, 10-20 parts of fructus aurantii, 10-30 parts of radix paeoniae alba, 10-20 parts of rhizoma cyperi, 10-20 parts of raw liquorice, 10-20 parts of honey-fried licorice root, 10-20 parts of cuttlebone, 10-20 parts of thunberg fritillary bulb, 10-20 parts of dandelion, 5-15 parts of coptis chinensis, 1-5 parts of fructus evodiae, 10-20 parts of herba eupatorii, 10-20 parts of scutellaria baicalensis, 9-20 parts of rhizoma pinellinae praeparata, 10-30 parts of poria cocos, 10-30 parts of burnt medicated leaven, 10-30 parts of burnt hawthorn, 10-30 parts of burnt malt, 10-30 parts of agastache rugosus, 5-15 parts of bulbus fritillariae cirrhosae and 5-15 parts of galangal;
wherein, the raw materials comprise fructus aurantii, rhizoma cyperi, raw liquorice, honey-fried licorice root, cuttlebone, thunberg fritillary bulb and dandelion in the same weight part; the weight parts of the coptis, the evodia, the bulbus fritilariae and the rhizoma pinellinae praeparata in the raw materials are less than those of other medicinal materials.
2. The traditional Chinese medicine composition as claimed in claim 1, wherein the weight portion of fructus evodiae in the raw materials is minimum.
3. A traditional Chinese medicine composition for treating gastritis comprises the following raw materials:
10 parts of radix bupleuri, 10 parts of fructus aurantii, 15 parts of radix paeoniae alba, 10 parts of rhizoma cyperi, 10 parts of raw liquorice, 10 parts of honey-fried licorice root, 10 parts of cuttlebone, 10 parts of thunberg fritillary bulb, 10 parts of dandelion, 10 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 6 parts of coptis chinensis, 2 parts of fructus evodiae, 15 parts of poria cocos, 10 parts of eupatorium, 15 parts of charred medicated leaven, 15 parts of charred hawthorn, 15 parts of charred malt, 10 parts of wrinkled gianthyssop herb, 6 parts of bulbus fritilariae and 6 parts of galangal.
4. A method for preparing the Chinese medicinal composition of any one of claims 1 to 3, comprising the steps of:
the raw materials in parts by weight are directly crushed or extracted by water or ethanol water solution, and are prepared into clinically acceptable preparations according to the conventional method in the field with or without pharmaceutically acceptable auxiliary materials.
5. The method of claim 4, wherein the clinically acceptable formulation is an oral formulation.
6. The method of claim 5, wherein the clinically acceptable formulation is a decoction, oral liquid, honeyed pill, watered pill, concentrated pill, capsule or tablet.
7. A medicament prepared by the process of any one of claims 4 to 6.
8. Use of the Chinese medicinal composition of any one of claims 1 to 3, or the medicament of claim 7, in the preparation of a medicament for the treatment of gastritis.
9. The use of claim 8, wherein the gastritis comprises acute gastritis and chronic gastritis; the chronic gastritis includes superficial gastritis, chronic erosive gastritis and atrophic gastritis.
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