CN117883544A - Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof, wherein the active components comprise the following raw materials in parts by weight: 5-10 parts of Hainandi, 10-15 parts of rhizoma pinellinae praeparata, 5-10 parts of dried ginger, 5-10 parts of coptis chinensis, 10-15 parts of radix scutellariae, 15-20 parts of radix astragali, 15-20 parts of poria cocos, 10-15 parts of stir-fried bighead atractylodes rhizome, 5-10 parts of fructus amomi, 9-12 parts of magnolia officinalis, 15-20 parts of stir-fried coix seed, 5-10 parts of rhizoma curcumae, 15-20 parts of oldenlandia diffusa, 10-15 parts of radix ranunculi ternati, 5-10 parts of liquorice, and further 5-10 parts of fritillaria thunbergii and 15-20 parts of cuttlebone; the traditional Chinese medicine formula has the effects of pungent and bitter taste reducing, qi replenishing and spleen invigorating, qi activating and blood activating, anticancer and detoxifying, and the active ingredients of the raw material medicine components are respectively prepared and mixed according to the principle of monarch, minister, assistant and guide, and the reasonable proportion is carried out according to the proportion relation of main symptoms and secondary symptoms and the interaction between medicines, so that the traditional Chinese medicine formula can effectively treat chronic atrophic gastritis caused by cold and heat mixed people and also has the treatment effects on spleen qi deficiency, stomach collateral stasis, toxin evil and the like.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof.
Background
Chronic atrophic gastritis is a type of chronic gastritis that is mainly characterized by a decrease in the intrinsic glands with or without intestinal glands and/or pseudo-pyloroadenogenesis. The world health organization defines chronic atrophic gastritis as a precancerous disease, and the main treatment means of modern medicine at present mainly consists in eradicating Hp, protecting gastric mucosa, promoting gastric motility, supplementing microelements and the like, and has no breakthrough progress on reversing the pathological changes of gastric mucosa and blocking the classical cascade mode of gastric cancer development. The traditional Chinese medicine has reliable curative effect in treating CAG, can effectively relieve clinical symptoms, can reverse gastric precancerous lesions, block cancerous processes, and radically reduce the incidence rate of gastric cancer.
The pathogenesis of the disease is considered as weakness of spleen and stomach and accumulation of toxin in the body by the traditional Chinese medicine. The spleen and stomach weakness and abnormal transportation and transformation of middle energizer are likely to produce pathological products such as qi stagnation, blood stasis, congealing cold, fire stagnation, dampness obstruction, etc., which are difficult to bond and separate with each other for a long time to form toxin and evil accumulation in the stomach collaterals, which is the disease. Spleen is yin, spleen diseases are easy to be deficient, qi diseases and yang are easy to occur, cold evil is generated internally, and cold nature is downward, which prevents the spleen from ascending clear; stomach is yang, which is the meridian of qi and blood, and stomach diseases are excessive, and their diseases are caused by yang transforming into heat and heat-inflammatory, which are unfavorable for the turbid reduction, so that the disease is most prone to cold and heat mix-up, deficiency and excess and other complex syndromes. For the treatment, the recipe is flexible and needs to treat both principal and secondary aspect of disease, treat deficiency and excess simultaneously, and regulate cold and heat. In addition, the disease belongs to chronic diseases, the treatment course is long, and the long-term administration of traditional Chinese medicine and the decoction process are complicated, so that the traditional Chinese medicine prescription with outstanding treatment effect is developed into a more portable Chinese patent medicine granule or oral liquid form, the defects can be overcome, and patients can easily adhere to the traditional Chinese medicine granule or oral liquid form to gain more benefit.
Disclosure of Invention
In view of the above, the invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof. The traditional Chinese medicine composition is suitable in compatibility of medicine materials, accords with the research theory of traditional Chinese medicine and modern medicine, has the characteristics of Hainan places, has the effects of pungent and bitter reducing, replenishing qi to invigorate the spleen, activating blood and promoting qi, resisting cancer and detoxifying, has good effect of treating chronic atrophic gastritis, is safe and free from toxic and side effects, and is prepared into granules or oral liquid which is most beneficial to gastric absorption to play a role, and compared with traditional Chinese medicine decoction, the traditional Chinese medicine composition better meets the requirement of patients for long-term administration.
The technical scheme of the invention is realized as follows: the traditional Chinese medicine composition for treating the chronic atrophic gastritis comprises the following active components in parts by weight: 5-10 parts of Hainandi, 10-15 parts of rhizoma pinellinae praeparata, 5-10 parts of dried ginger, 5-10 parts of coptis chinensis, 10-15 parts of radix scutellariae, 15-20 parts of radix astragali, 15-20 parts of poria cocos, 10-15 parts of stir-fried bighead atractylodes rhizome, 5-10 parts of fructus amomi, 9-12 parts of magnolia officinalis, 15-20 parts of stir-fried coix seed, 5-10 parts of rhizoma curcumae, 15-20 parts of oldenlandia diffusa, 10-15 parts of radix ranunculi ternati and 5-10 parts of liquorice.
Further scheme, the traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 6-9 parts of Hainan Di-containing, 11-14 parts of rhizoma pinellinae praeparata, 6-9 parts of dried ginger, 6-9 parts of coptis chinensis, 11-14 parts of radix scutellariae, 16-19 parts of radix astragali, 16-19 parts of poria cocos, 11-14 parts of stir-fried bighead atractylodes rhizome, 6-9 parts of fructus amomi, 10-11 parts of magnolia officinalis, 16-19 parts of stir-fried coix seed, 6-9 parts of rhizoma curcumae, 16-19 parts of oldenlandia diffusa, 11-14 parts of radix ranunculi ternati and 6-9 parts of liquorice.
Further scheme, a traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 8 parts of Hainan Di, 12 parts of rhizoma pinellinae praeparata, 7 parts of dried ginger, 7 parts of coptis chinensis, 12 parts of radix scutellariae, 17 parts of radix astragali, 18 parts of poria cocos, 13 parts of stir-fried bighead atractylodes rhizome, 7 parts of fructus amomi, 10 parts of magnolia officinalis, 17 parts of stir-fried coix seed, 7 parts of rhizoma curcumae, 17 parts of oldenlandia diffusa, 13 parts of radix ranunculi ternati and 7 parts of liquorice.
In a further scheme, the active components of the traditional Chinese medicine composition for treating the chronic atrophic gastritis also comprise 5-10 parts of fritillary bulb and 15-20 parts of cuttlebone.
In a further scheme, the traditional Chinese medicine composition is prepared into clinically acceptable granules or oral liquid.
Further scheme, a preparation method of a traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps:
Step S1: selecting rhizoma Pinelliae Preparata, coptidis rhizoma and Scutellariae radix according to the above ratio, placing into a microwave irradiation box, and irradiating at 400-600MHz for 15-25min; soaking with 2-5 times of extraction solvent for 8-16 hr, heating and refluxing for 2-5 hr, collecting extractive solution, soaking with 1-3 times of extraction solvent for 3-6 hr, heating and refluxing for 1.5-3.5 hr, collecting extractive solution, mixing the two extractive solutions, filtering, and concentrating the filtrate to obtain medicinal liquid I;
step S2: mixing radix astragali, parched Atractylodis rhizoma, fructus Amomi, cortex Magnolia officinalis, poria, parched Coicis semen, curcumae rhizoma and herba Hedyotidis Diffusae, pulverizing into powder of 0.01-200 μm, adding leaching solvent to wet the medicinal powder, stirring, sealing, standing for 15-120min, percolating in percolator for 15-30min, collecting percolate, and concentrating to obtain medicinal liquid II;
Step S3: mixing radix Ranunculi Ternati, zingiberis rhizoma, glycyrrhrizae radix, bulbus Fritillariae Thunbergii, and Os Sepiae, adding 3-6 times of water or 58-98% ethanol solution, decocting for 2-4 times, 30-90min each time, separating solid from liquid, and collecting decoction;
Step S4: mixing the above medicinal liquid I, medicinal liquid II and decoction, and stirring under ultrasonic condition for 10-40min to obtain medicinal liquid.
In a further scheme, the extraction solvent in the step 1 is a mixed solution of ethanol and acetic acid with a volume ratio of 4-7:2.5.
In a further scheme, the percolation extraction temperature in the step 2 is 50-80 ℃, the percolation flow rate is 10-20mL/min, and the percolation pressure is 0.2-0.4MPa.
In a further scheme, the decoction and extraction temperature in the step3 is 95-100 ℃.
In a further scheme, the ultrasonic frequency in the step 4 is 45-55kHz, the ultrasonic power is 2500-3000W/m 2, and the stirring speed is 250-350rpm.
The theoretical basis of the invention is studied:
all the ingredients are as follows: [ the nature and flavor enter meridians ]; [ functional indications ] pain relieving, heat-clearing and detoxicating, malaria-stopping, intestine moistening and constipation relieving, and can be used for treating stomach ache, tumor, carbuncle swelling and pain, pharyngitis, malaria, toothache, sore throat, venomous snake bite, etc.
Rhizoma Pinelliae Preparata: [ the nature enters meridians ] pungent and warm. Spleen, stomach and lung meridian; [ Functions ] the preparation is effective in eliminating dampness and phlegm, lowering adverse qi, relieving vomiting, relieving distention and fullness, and resolving hard mass, and can be used for treating adverse rising of stomach qi, nausea and emesis, chest distress, globus hystericus, etc.
Dried ginger: [ the nature and flavor enter meridians ] the flavor is pungent and hot, enters spleen, stomach, heart and lung meridians; [ FUNCTIONS ] the decoction has the effects of warming spleen and stomach, dispelling cold, restoring yang, dredging collaterals, warming lung and resolving fluid retention. Can be used for treating cold pain of stomach and abdomen, emesis, diarrhea, cold limbs, and cough due to phlegm and retained fluid.
Coptis root: [ the nature and flavor enter meridians ] bitter and cold, and they are attributed to the meridians of the heart, liver, stomach and large intestine; [ functional indications ] has the effects of clearing heat, drying dampness, purging pathogenic fire, and removing toxin, and can be used for treating diarrhea, emesis, dysentery, etc. caused by damp-heat in intestines and stomach.
Radix Scutellariae Baicalensis: [ the nature and flavor enter meridians ] bitter and cold in flavor, enter lung, stomach and large intestine meridians; [ Functions ] can be used for treating damp-heat, summer-heat, chest distress, vomiting, damp-heat distention and fullness, diarrhea, jaundice, cough due to lung-heat, polydipsia due to high fever, hematemesis, carbuncle, sore, and threatened abortion.
Radix astragali: [ the nature and flavor enter meridians ]; [ FUNCTIONS ] can tonify qi, raise yang, strengthen superficies, arrest sweating, induce diuresis to alleviate edema, remove toxic substances, promote granulation, treat deficiency of lung-qi and spleen-qi, short breath, debilitation, loose stool, anorexia, arthralgia, numbness, chronic diarrhea, rectocele, visceral prolapse, spontaneous perspiration edema, etc.
Stir-frying white atractylodes rhizome: [ the nature enters meridians ]; spleen and stomach two meridians; [ FUNCTIONAL INDISTRATED ] has effects in invigorating spleen, replenishing qi, eliminating dampness, promoting diuresis, consolidating superficial resistance, stopping sweat, preventing miscarriage, and treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous sweat, fetal movement, etc.
Poria cocos: [ the nature enters meridians ], the nature is sweet, light and flat, and enters the three meridians of heart, spleen and kidney. [ functional indications ] induce diuresis, excrete dampness, invigorate the spleen and calm the heart. Can be used for treating spleen deficiency, anorexia, loose stool, diarrhea, edema, oliguria, phlegm retention, dizziness, palpitation, etc.
Fructus Amomi: [ the nature enters meridians ]; [ functional indications ] resolving dampness, stimulating appetite, warming spleen and stomach, relieving diarrhea, regulating qi-flowing and preventing miscarriage. Can be used for treating damp obstruction in middle energizer, gastric distention and fullness, deficiency cold in spleen and stomach, emesis, diarrhea, and vomiting of pregnancy.
Cortex Magnoliae officinalis: [ the nature and flavor enter meridians ] the nature and flavor are pungent, bitter and warm, and they are attributed to spleen, stomach, lung and large intestine meridians; [ Functions ] Dry dampness and resolve phlegm, descend qi and remove fullness. It is indicated for damp stagnation with middle energizer and food stagnation with qi stagnation.
Parching Coicis semen: [ the nature enters meridians ], it is sweet and light in flavor, slightly cold in nature. Enter spleen, stomach and lung meridians. [ Functions ] the traditional Chinese medicine composition has the effects of promoting diuresis, removing dampness, strengthening spleen, relieving diarrhea, removing arthralgia, expelling pus, and removing toxic materials and resolving masses.
Zedoary turmeric: [ the nature and flavor enter meridians ] the nature and flavor are pungent, bitter, warm, enter liver and spleen meridians; [ functional indications ] move qi, break blood, remove food retention and relieve pain. Can be used for treating blood qi and heart pain, food stagnation, abdominal distention and pain, amenorrhea due to blood stagnation, dysmenorrhea, abdominal mass, and traumatic injury.
Herba Hedyotidis Diffusae: [ the nature and flavor enter meridians ] the nature and flavor is bitter, sweet and cold, enters the stomach, large intestine and small intestine; [ functional indications ] lung heat asthma and cough, sore throat, acute appendicitis, furuncle, sore and ulcer, venomous snake bite, heat stranguria and pain, edema, dysentery, enteritis and damp-heat jaundice are used for various cancers such as gastric cancer, esophageal cancer, rectal cancer and the like in modern trial.
Radix Ranunculi Ternati: [ the nature and flavor enter meridians ] sweet and spicy, warm; sex level; liver and lung meridian; [ Functions ] detoxify, resolve phlegm and dissipate nodulation. Is used for treating scrofula, tuberculosis, pharyngitis, furuncle, snake bite, malaria, migraine, and toothache.
Licorice root: [ the nature enters meridians ], it is sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. [ functional indications ] the medicine has the functions of invigorating spleen, replenishing qi, clearing away heat and toxic material, eliminating phlegm, relieving cough, relieving spasm and pain and regulating the medicines.
Thunberg fritillary bulb: [ the nature enters meridians ], bitter in flavor, cold in nature, enters lung and heart meridians. [ functional indications ] clearing heat, resolving phlegm, relieving cough, detoxifying, resolving masses and resolving carbuncles, and mainly treating wind-heat, phlegm-heat cough, gall, sore, carbuncles and the like.
Cuttlebone: [ it enters meridians with warm nature, salty and astringent taste ], enters both liver and kidney meridians. The product has effects of astringing, stopping bleeding, relieving hyperacidity, relieving pain, eliminating dampness, and healing sore, and can be used for treating various hemorrhagic diseases, stomach ache, belch, acid regurgitation, and eczema ulcer.
The pinellia tuber with pungent and warm nature in the traditional Chinese medicine composition has the effects of resolving masses, relieving stuffiness, lowering adverse flow of qi, preventing vomiting, and being bitter and slightly cold in taste, and is also called as a monarch drug for strengthening spleen, relieving pain, clearing heat and detoxicating, and combining cold and warm. The ministerial drugs are pungent and hot in nature and warm in nature to dispel cold, the bitter and cold in nature and warm in nature and cold and hot in nature are mutually combined to regulate the ascending and descending of the dry ginger, and the reinforcing and reducing effects are combined to take account of deficiency and excess. Astragalus mongholicus has the effects of tonifying spleen and stomach, expelling toxin and promoting granulation, inducing diuresis and relieving swelling, and is used for treating spleen and stomach weakness and toxin evil accumulation, is matched with poria cocos and bighead atractylodes rhizome which are good in tonifying and benefiting, and is also sweet and light in nature, excretes dampness and turbid, so that the effects of tonifying without stagnation are achieved, and the effects of tonifying ginger, magnolia officinalis and fructus amomi are used for activating qi, drying dampness and harmonizing stomach, and tonifying and nourishing are achieved. Meanwhile, according to syndrome differentiation, blood-activating, detoxifying and anticancer drugs such as curcuma zedoary, oldenlandia diffusa, radix ranunculi ternati, stir-fried coix seed and the like are added, so that the pathogenic toxin in the stomach is cleared, gastric mucosa atrophy, intestinal metaplasia and intraepithelial neoplasia are inhibited, the occurrence rate of canceration is reduced, roasted liquorice is used for the five purposes, and the effects of nourishing qi, promoting astragalus and tonifying middle-jiao and qi are achieved by the roasted liquorice, so that the drugs are blended together, and the effect of assisting is achieved.
Compared with the prior art, the invention has the beneficial effects that:
The prescription of the invention follows the basic theory of traditional Chinese medicine, has proper monarch, minister, assistant and guide compatibility, has the functions of pungent and bitter reducing, replenishing qi to invigorate the spleen, promoting blood circulation to promote qi circulation, resisting cancer and detoxification, can improve the symptoms of stomachache, gastrectasia, acid regurgitation, belch and the like of chronic atrophic gastritis patients, reverse the pathological changes of the chronic atrophic gastritis, reduce inflammation and inhibit gastric mucosa atrophy, and can promote the repair and regeneration of gastric mucosa, thereby restoring the normal structure and function of gastric mucosa, enhancing the resistance of organisms and reducing the recurrence risk by regulating the immune function of the patients.
Drawings
FIG. 1 is a graph of the change in body weight of a normal group and a model group (weeks 0-22) during molding;
FIG. 2 shows changes in body weight of normal and individual groups (22-30 weeks) during treatment;
FIG. 3 is a chart of the pathology of HE staining of gastric mucosal tissue of rats of each group (x 200); in the figure: n: normal group; m: a model group; g: a high dose group; z: medium dose group; d, a step of performing the process; low dose group; y: folic acid group. The following figures are the same. Red arrow: mucous membrane vasodilation congestion; blue arrow: gland atrophy; green arrow: denaturation and necrosis; black arrow: inflammatory cell infiltration;
Fig. 4 shows gastric mucosa manifestation under gastroscope before and after treatment of folic acid tablet of CAG patient, wherein (left) is before treatment and (right) is after treatment.
Fig. 5 shows gastric mucosa manifestations under gastroscope before and after treatment of the Jiujiejianwei Jiedu decoction for CAG patients, wherein (left) is before treatment and (right) is after treatment.
Fig. 6 shows pathological changes of gastric mucosa before and after treatment of folic acid tablets of patients with CAG, wherein (left) is before treatment and (right) is after treatment.
Fig. 7 shows pathological changes of gastric mucosa before and after treatment of the decoction for treating gastric mucosa in CAG patients, wherein (left) is before treatment and (right) is after treatment.
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
Example 1
A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 5g of Hainandi, 10g of rhizoma pinellinae praeparata, 5g of dried ginger, 5g of coptis chinensis, 10g of radix scutellariae, 15g of radix astragali, 15g of poria cocos, 10g of stir-fried bighead atractylodes rhizome, 5g of fructus amomi, 9 g of magnolia officinalis, 15g of stir-fried coix seed, 5g of rhizoma curcumae, 15g of oldenlandia diffusa, 10g of radix ranunculi ternati, 5g of liquorice, 5g of fritillaria thunbergii and 15g of cuttlebone.
Example 2
A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 10g of Hainandi, 15 g of rhizoma pinellinae praeparata, 10g of dried ginger, 10g of coptis chinensis, 15 g of radix scutellariae, 20g of radix astragali, 20g of poria cocos, 15 g of stir-fried bighead atractylodes rhizome, 10g of fructus amomi, 12 g of magnolia officinalis, 20g of stir-fried coix seed, 10g of rhizoma curcumae, 20g of oldenlandia diffusa, 15 g of radix ranunculi ternati, 10g of liquorice, 10g of fritillaria thunbergii and 20g of cuttlebone;
the following preparation methods were employed in the above examples 1-2:
Step S1: selecting Hainan Di Cao, rhizoma Pinelliae Preparata, coptidis rhizoma and Scutellariae radix according to the above proportion, placing into a microwave irradiation box, and irradiating for 15min at microwave frequency of 400 MHz; soaking with 2 times of extraction solvent for 8 hr, heating and refluxing for 2 hr, collecting extractive solution, adding 1 time of extraction solvent and soaking for 3 hr, heating and refluxing for 1.5 hr, collecting extractive solution, mixing the two extractive solutions, filtering, and concentrating the filtrate to obtain medicinal liquid I;
step S2: mixing radix astragali, parched Atractylodis rhizoma, fructus Amomi, cortex Magnolia officinalis, poria, parched Coicis semen, curcumae rhizoma and herba Hedyotidis Diffusae, pulverizing into 10 μm powder, adding leaching solvent to wet the powder, stirring, standing for 15min under sealed condition, percolating in percolator for 15min, collecting percolate, and concentrating to obtain liquid medicine II;
Step S3: mixing radix Ranunculi Ternati, zingiberis rhizoma, glycyrrhrizae radix, bulbus Fritillariae Thunbergii, and Os Sepiae, adding 3 times of water or 58% ethanol solution, decocting at 95deg.C for 2 times, 30min each time, separating solid and liquid, and collecting decoction;
Step S4: mixing the above medicinal liquid I, medicinal liquid II and decoction, and stirring at ultrasonic frequency of 45kHz, ultrasonic power of 2500W/m 2 and stirring speed of 250rpm for 10min to obtain medicinal liquid.
Example 3
A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 6 g of Hainandi, 11 g of rhizoma pinellinae praeparata, 6 g of dried ginger, 6 g of coptis chinensis, 11 g of radix scutellariae, 16 g of radix astragali, 16 g of poria cocos, 11 g of stir-fried bighead atractylodes rhizome, 6 g of fructus amomi, 10g of magnolia officinalis, 16 g of stir-fried coix seed, 6 g of rhizoma curcumae, 16 g of oldenlandia diffusa, 11 g of radix ranunculi ternati and 6 g of liquorice.
Example 4
A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 9 g of Hainandi, 14 g of rhizoma pinellinae praeparata, 9 g of dried ginger, 9 g of coptis chinensis, 14 g of radix scutellariae, 19 g of radix astragali, 19 g of poria cocos, 14 g of stir-fried bighead atractylodes rhizome, 9 g of fructus amomi, 11 g of magnolia officinalis, 19 g of stir-fried coix seed, 9 g of rhizoma curcumae, 19 g of oldenlandia diffusa, 14 g of radix ranunculi ternati and 9 g of liquorice;
the following preparation methods were employed for the above examples 3-4:
step S1: selecting Hainan Di Cao, rhizoma Pinelliae Preparata, coptidis rhizoma and Scutellariae radix according to the above proportion, placing into a microwave irradiation box, and irradiating at microwave frequency of 600MHz for 25min; soaking with 5 times of extraction solvent for 16 hr, heating and refluxing for 5 hr, collecting extractive solution, adding 3 times of extraction solvent and soaking for 6 hr, heating and refluxing for 3.5 hr, collecting extractive solution, mixing the two extractive solutions, filtering, and concentrating the filtrate to obtain medicinal liquid I;
Step S2: mixing radix astragali, parched Atractylodis rhizoma, fructus Amomi, cortex Magnolia officinalis, poria, parched Coicis semen, curcumae rhizoma and herba Hedyotidis Diffusae, pulverizing into 200 μm powder, adding leaching solvent to wet the powder, stirring, standing for 120min under sealed condition, percolating in percolator for 30min, collecting percolate, and concentrating to obtain medicinal liquid II;
step S3: mixing radix Ranunculi Ternati, zingiberis rhizoma, glycyrrhrizae radix, bulbus Fritillariae Thunbergii, and Os Sepiae, adding 6 times of water or 98% ethanol solution, decocting at 100deg.C for 4 times, each time for 90min, separating solid and liquid, and collecting decoction;
Step S4: mixing the above medicinal liquid I, medicinal liquid II and decoction, and stirring at ultrasonic frequency of 55kHz, ultrasonic power of 3000W/m 2 and stirring speed of 350rpm for 40min to obtain medicinal liquid.
Example 5
A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following active components in parts by weight: 8g of Hainandi, 12 g of rhizoma pinellinae praeparata, 7 g of dried ginger, 7 g of coptis chinensis, 12 g of radix scutellariae, 17 g of radix astragali, 18 g of poria cocos, 13 g of stir-fried bighead atractylodes rhizome, 7 g of fructus amomi, 10 g of magnolia officinalis, 17 g of stir-fried coix seed, 7 g of rhizoma curcumae, 17 g of oldenlandia diffusa, 13 g of radix ranunculi ternati, 7 g of liquorice, 7 g of fritillaria thunbergii and 17 g of cuttlebone;
the following preparation method was adopted in the above example 5:
Step S1: selecting Hainan Di Cao, rhizoma Pinelliae Preparata, coptidis rhizoma and Scutellariae radix according to the above proportion, placing into a microwave irradiation box, and irradiating for 20min at microwave frequency of 500 MHz; soaking with 3 times of extraction solvent for 12 hr, heating and refluxing for 3 hr, collecting extractive solution, adding 2 times of extraction solvent and soaking for 5 hr, heating and refluxing for 2.5 hr, collecting extractive solution, mixing the two extractive solutions, filtering, and concentrating the filtrate to obtain medicinal liquid I;
Step S2: mixing radix astragali, parched Atractylodis rhizoma, fructus Amomi, cortex Magnolia officinalis, poria, parched Coicis semen, curcumae rhizoma and herba Hedyotidis Diffusae, pulverizing into 100 μm powder, adding leaching solvent to wet the powder, stirring, standing for 60min under sealed condition, percolating in percolator for 23min, collecting percolate, and concentrating to obtain liquid medicine II;
step S3: mixing radix Ranunculi Ternati, zingiberis rhizoma, glycyrrhrizae radix, bulbus Fritillariae Thunbergii, and Os Sepiae, adding 3-6 times of water or 58-98% ethanol solution, decocting at 100deg.C for 3 times, each time for 60min, separating solid and liquid, and collecting decoction;
Step S4: mixing the above medicinal liquid I, medicinal liquid II and decoction, and stirring at ultrasonic frequency of 50kHz, ultrasonic power of 2700W/m 2 and stirring speed of 30rpm for 30min to obtain medicinal liquid.
EXAMPLE 6 pharmacodynamic Studies of the invention
6.1 Experimental animals: 66 SPF Wistar male rats weighing 100-130g and 3-4 weeks old were purchased from Tian-Di-Biotechnology Co., ltd., license number: SCXK (Hunan) 2019-0014, raising in laboratory animal center of Hospital of Hainan province, maintaining at room temperature 22+ -2deg.C and humidity 55% + -5%, maintaining circadian rhythm for 12 hr, and freely eating and drinking water. The laboratory animals were humanly cared for following the 3R principle.
6.2 Grouping and modeling administration of animals: after 1 week of adaptive feeding, the animals were randomly divided into 2 groups, namely a normal group and a CAG model group. Normal group 6, CAG model group 60. Normal diet and free drinking water are given to the normal group. The CAG model group is given with 150 mug/mL MNNG drinking liquid for free drinking, and on the basis, a classical hunger and satiety normal method (1 day of feeding and 1 day of fasted) is adopted, continuous modeling is carried out until 16 weeks, 5 CAG model group rats are randomly extracted, and gastric mucosa pathology morphological examination is carried out, and pathology of more than or equal to 3 rats is shown as gastric mucosa intrinsic glandular atrophy, so that modeling success is indicated.
The drug administration is started after the molding is successful, and the specific drug administration method is as follows: CAG model groups were randomly divided into 5 groups: model group, high-dose group of traditional Chinese medicine formula, medium-dose group of traditional Chinese medicine formula, low-dose group of traditional Chinese medicine formula and folic acid group. Traditional Chinese medicine formula (8 g of Hainandi, 12 g of rhizoma pinellinae praeparata, 7g of dried ginger, 7g of coptis chinensis, 12 g of radix scutellariae, 17 g of radix astragali, 18 g of poria cocos, 13 g of fried bighead atractylodes rhizome, 7g of fructus amomi, 10 g of magnolia officinalis, 17 g of fried coix seed, 7g of rhizoma curcumae, 17 g of oldenlandia diffusa, 13 g of radix ranunculi ternati, 7g of liquorice, 7g of fritillaria thunbergii and 17 g of cuttlebone). The number of the models is 11, the number of the traditional Chinese medicine formulas is 11, and the number of the folic acid groups is 11. Prescription crude drugs are provided by Hainan GuoRuitang Chinese medicine pharmaceutical Co.Ltd, and quality inspection reports are attached to all the crude drugs. Folic acid tablet is provided by Jiangsu Asian eplerian pharmaceutical company limited (approval document: national drug standard H32023288, product lot number: 1507026), and has a specification of 5mg×100 tablets/bottle. After the successful molding, the stomach is continuously irrigated for 8 weeks, the high, medium and low dosage groups of the Stephania sinica Diels stomach-invigorating and detoxifying decoction have the administration concentrations of 2.57g/ml/d, 1.93g/ml/d and 1.29g/ml/d respectively, and folic acid groups are folic acid 1.43mg/kg/d. Normal and model groups were given equal amounts of physiological saline. The stomach volume was 10ml/kg, and the body weight was measured once a week, 1 time a day. Rats that die during the experiment were dissected to understand the cause of death and to observe changes in gastric mucosa in pathomorphology.
6.3 Experimental results: with reference to figures 1 to 2 of the drawings,
(1) Rat general case comparison: in the modeling process, rats in the normal group and the model group have no obvious abnormal behaviours, the food and water intake of the rats in the normal group are normal, and the weight of the rats is gradually increased. Rats in the model group exhibited reduced water intake and weight loss. In the administration process, rats in normal groups have good growth conditions, more eating, stable weight increase, obesity, good mental state, activity and response, and luster of fur. After model building is stopped, diet of the model group is slightly increased, fur is scattered, and rats of the model group are not obviously increased in weight. The mental state, the food intake, the activity and the like of the residual dose group and the folic acid group are between the two, and the fur is softer and softer than the fur during molding, so that the weight is steadily increased.
(2) Gastric mucosa pathology HE staining results of rats in each group
The normal group of rats has complete gastric mucosa tissue structure, and the epithelial cells are orderly arranged, and no obvious erosion and atrophy are seen. The gastric mucosal layer of the rats in the model group had vasodilatory congestion, glandular atrophy, visible degeneration, necrosis and disordered arrangement of glandular epithelial cells. The folic acid group can be seen in the obvious blood vessel mild dilatation congestion of the mucous membrane layer, gland atrophy, gland epithelial cell degeneration and arrangement disorder. Scattered in small amounts of lymphocyte and monocyte infiltrates. The different dosage groups of the Stephania sinica Diels decoction can cause vasodilation congestion of mucous membrane layers, gland atrophy with different degrees, and small amount of lymphocyte, monocyte infiltration and neutrophil infiltration. The stomach mucosa tissue pathology of rats in the high, medium and low dose groups and folic acid groups of the Stephania sinica Diels decoction is higher than that of rats in the model group, the glands are increased, the arrangement is regular, and inflammatory cell infiltration is reduced. And (3) result prompting: the Stephania sinica Diels stomach-invigorating and detoxifying soup with different dosages has a certain curative effect in improving the pathological histology of gastric mucosa of CAG rats. See fig. 3.
The results show that the pharmaceutical composition provided by the invention can be used for effectively treating chronic atrophic gastritis, and especially has a certain curative effect in improving gastric mucosa histopathology.
EXAMPLE 7 clinical application of the Chinese medicinal composition of the present invention
86 Cases of chronic atrophic gastritis patients meeting the diagnosis and inclusion criteria are collected together, and after the patients are removed according to the removal criteria, 84 cases are counted in total. An open random control design was used. The control group received folic acid tablet treatment, and the test group received Stephania sinica Diels stomach strengthening and detoxicating decoction treatment. All patients need to complete 13C-urea or 14C-urea breath test before entering the group, if the breath test is positive, hp is eradicated, and after 1 month, the patients re-enter the group after checking that the 13C or 14C breath test is negative.
Results of the study
According to the effective rate of the total integral of the symptoms of the traditional Chinese medicine, 1 part of the Stephania sinica Diels decoction for strengthening stomach and removing toxicity is cured, 32 parts of the decoction are effective, 7 parts of the decoction are effective, 6 parts of the decoction are ineffective, 0 part of the decoction is cured, 18 parts of the decoction are effective, 13 parts of the decoction are effective, 10 parts of the decoction are ineffective, the total effective rate of the decoction is 93.02% and the total effective rate of the folic acid tablet is 75.60%.
Table 1 evaluation of clinical symptoms of chinese medicine efficacy after treatment of two groups of patients
Note that: ① The traditional Chinese medicine symptom curative effect is compared with folic acid tablets, ΔP＜0.05,② total effective rate is compared with folic acid tablets, and Δ P is less than 0.05.
(II) comparison of gastroscopy efficacy
The gastroscopy integral of the two groups before and after treatment is compared, the gastroscopy performance improvement condition of the Stephania sinica Diels stomach strengthening and detoxifying decoction group is superior to that of a folic acid control group, and the difference has statistical significance.
Table 2 comparison of gastroscopies for two groups of patients
Note that: * P is less than 0.05, before VS treatment; Δ P < 0.05, VS folic acid tablet group
Referring to FIGS. 4-5, gastric mucosal manifestations under gastroscope before and after CAG patient treatment
(III) comparison of therapeutic effects of pathological histological examination
Statistical analysis shows that the treatment of the two groups of patients before and after treatment and the treatment of the decoction group of the Stephania sinica Diels for strengthening stomach and removing toxic substances are better than that of the folic acid tablet group in terms of stage conditions of OLGA and OLGIM and improvement of pathological tissue integral.
TABLE 3 treatment of two groups of patients before and after OLGA, OLGIM staging conditions (f)
Note that: ① OLGA stage condition, P < 0.05VS folic acid tablet group, ② OLGIM stage condition, P < 0.05VS folic acid tablet group
Table 4 evaluation of pathohistological curative effect of two groups of patients
Note that: p < 0.05 compared with folic acid tablet group
Referring to fig. 6-7, gastric mucosa pathological changes before and after CAG patients are treated.
Example 8 typical case
Yellow to a certain degree, 21 years old, 12 months 13 days in 2019, and 3 years old for repeated epigastric distending pain. The patient has discomfort of swelling pain in the upper abdomen, belch, severe after eating, nausea, vomiting, hematemesis, and black stool due to irregular eating for 3 years ago, and the first affiliated hospital of the medical college of Hainan is gastroscopy from the 18 th year of 2017 01: 1. the gastric sinus huge ulcer, the pylorus stenosis, the bile reflux gastritis, the symptom is relieved after western medicine treatment (in detail, but not detail), and the repeated abdominal discomfort still exists. Gastroscope was reviewed in 2019, 10, 19: 1. antral ulcer stage S2 (to be pathologic), 2. Chronic superficial gastritis is accompanied by bile reflux; pathological diagnosis: (antrum) chronic peptic ulcer, chronic atrophic gastritis with intestinal metaplasia. Western diagnosis: chronic atrophic gastritis. Diagnosis of traditional Chinese medicine: gastric fullness (cold and heat syndrome). The treatment method comprises the following steps: regulate cold and heat, promote qi circulation and relieve distention and fullness. The administration of the traditional Chinese medicine composition of the embodiment 2 of the invention is instructed: 10g of rhizoma pinellinae praeparata, 10g of Hainan Di-containing (Stephania sinica Diels), 5g of dried ginger, 5g of coptis chinensis, 10g of radix scutellariae, 10g of magnolia officinalis, 30g of astragalus membranaceus, 15g of poria cocos, 10g of stir-fried bighead atractylodes rhizome, 30g of stir-fried coix seed, 15g of rhizoma curcumae, 30g of oldenlandia diffusa and 10g of honey-fried licorice root. The usage method is as follows: the medicine is taken after 1 dose a day and decocted in water, and is taken separately in the morning and evening for 7 doses. The continuous medication is adjusted slightly for 4 months, and the gastroscope is reviewed in 2020, 10 and 19 days: 1. gastric Dou Duo ulcers stage S1, 2. Chronic atrophic gastritis, pathological diagnosis: (antrum of stomach) chronic superficial-atrophic gastritis with erosion and active phase. Compared with gastroscope and pathological results of 2019 patients, intestinal epithelial metaplasia is not seen, and the atrophy degree of mucous membrane is reduced.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (10)
1.A traditional Chinese medicine composition for treating chronic atrophic gastritis is characterized in that: the active components of the composition comprise the following raw materials in parts by weight: 5-10 parts of Hainandi, 10-15 parts of rhizoma pinellinae praeparata, 5-10 parts of dried ginger, 5-10 parts of coptis chinensis, 10-15 parts of radix scutellariae, 15-20 parts of radix astragali, 15-20 parts of poria cocos, 10-15 parts of stir-fried bighead atractylodes rhizome, 5-10 parts of fructus amomi, 9-12 parts of magnolia officinalis, 15-20 parts of stir-fried coix seed, 5-10 parts of rhizoma curcumae, 15-20 parts of oldenlandia diffusa, 10-15 parts of radix ranunculi ternati and 5-10 parts of liquorice.
2. The traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 1, wherein: the active components of the composition comprise the following raw materials in parts by weight: 6-9 parts of Hainan Di-containing, 11-14 parts of rhizoma pinellinae praeparata, 6-9 parts of dried ginger, 6-9 parts of coptis chinensis, 11-14 parts of radix scutellariae, 16-19 parts of radix astragali, 16-19 parts of poria cocos, 11-14 parts of stir-fried bighead atractylodes rhizome, 6-9 parts of fructus amomi, 10-11 parts of magnolia officinalis, 16-19 parts of stir-fried coix seed, 6-9 parts of rhizoma curcumae, 16-19 parts of oldenlandia diffusa, 11-14 parts of radix ranunculi ternati and 6-9 parts of liquorice.
3. The traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 1, wherein: the active components of the composition comprise the following raw materials in parts by weight: 8 parts of Hainan Di, 12 parts of rhizoma pinellinae praeparata, 7 parts of dried ginger, 7 parts of coptis chinensis, 12 parts of radix scutellariae, 17 parts of radix astragali, 18 parts of poria cocos, 13 parts of stir-fried bighead atractylodes rhizome, 7 parts of fructus amomi, 10 parts of magnolia officinalis, 17 parts of stir-fried coix seed, 7 parts of rhizoma curcumae, 17 parts of oldenlandia diffusa, 13 parts of radix ranunculi ternati and 7 parts of liquorice.
4. The traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 1, wherein: the active components also comprise 5-10 parts of fritillaria thunbergii and 15-20 parts of cuttlebone.
5. The traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 1, wherein: the traditional Chinese medicine composition is prepared into clinically acceptable granules or oral liquid.
6. The method for preparing the traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 1, wherein the method comprises the following steps: the method comprises the following steps:
Step S1: selecting rhizoma Pinelliae Preparata, coptidis rhizoma and Scutellariae radix according to the above ratio, placing into a microwave irradiation box, and irradiating at 400-600MHz for 15-25min; soaking with 2-5 times of extraction solvent for 8-16 hr, heating and refluxing for 2-5 hr, collecting extractive solution, soaking with 1-3 times of extraction solvent for 3-6 hr, heating and refluxing for 1.5-3.5 hr, collecting extractive solution, mixing the two extractive solutions, filtering, and concentrating the filtrate to obtain medicinal liquid I;
step S2: mixing radix astragali, parched Atractylodis rhizoma, fructus Amomi, cortex Magnolia officinalis, poria, parched Coicis semen, curcumae rhizoma and herba Hedyotidis Diffusae, pulverizing into powder of 0.01-200 μm, adding leaching solvent to wet the medicinal powder, stirring, sealing, standing for 15-120min, percolating in percolator for 15-30min, collecting percolate, and concentrating to obtain medicinal liquid II;
Step S3: mixing radix Ranunculi Ternati, zingiberis rhizoma, glycyrrhrizae radix, bulbus Fritillariae Thunbergii, and Os Sepiae, adding 3-6 times of water or 58-98% ethanol solution, decocting for 2-4 times, 30-90min each time, separating solid from liquid, and collecting decoction;
Step S4: mixing the above medicinal liquid I, medicinal liquid II and decoction, and stirring under ultrasonic condition for 10-40min to obtain medicinal liquid.
7. The method for preparing the traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 6, wherein the method comprises the following steps: the extraction solvent in the step 1 is ethanol and acetic acid mixed solution with the volume ratio of 4-7:2.5.
8. The method for preparing the traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 6, wherein: the percolation extraction temperature in the step 2 is 50-80 ℃, the percolation flow rate is 10-20mL/min, and the percolation pressure is 0.2-0.4MPa.
9. The method for preparing the traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 6, wherein the method comprises the following steps: the decoction and extraction temperature in the step 3 is 95-100 ℃.
10. The method for preparing the traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 6, wherein the method comprises the following steps: the ultrasonic frequency in the step 4 is 45-55kHz, the ultrasonic power is 2500-3000W/m 2, and the stirring speed is 250-350rpm.
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