CN116390941A - 多特异性嵌合抗原受体及其用途 - Google Patents

多特异性嵌合抗原受体及其用途 Download PDF

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CN116390941A
CN116390941A CN202180061010.4A CN202180061010A CN116390941A CN 116390941 A CN116390941 A CN 116390941A CN 202180061010 A CN202180061010 A CN 202180061010A CN 116390941 A CN116390941 A CN 116390941A
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seq
amino acid
acid sequence
cdr3
cdr2
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范晓虎
周喆
潘红波
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K40/4212—CD22, BL-CAM, siglec-2 or sialic acid binding Ig-related lectin 2
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    • A61K40/41—Vertebrate antigens
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CN202180061010.4A 2020-07-16 2021-07-16 多特异性嵌合抗原受体及其用途 Pending CN116390941A (zh)

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CNPCT/CN2020/102470 2020-07-16
CN2020102470 2020-07-16
PCT/CN2021/106889 WO2022012681A1 (en) 2020-07-16 2021-07-16 Multispecific chimeric antigen receptors and uses thereof

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US (1) US20230257475A1 (https=)
EP (1) EP4182356A4 (https=)
JP (1) JP2023546766A (https=)
KR (1) KR20230040333A (https=)
CN (1) CN116390941A (https=)
AU (1) AU2021308745A1 (https=)
CA (1) CA3189531A1 (https=)
IL (1) IL299865A (https=)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025146143A1 (zh) * 2024-01-05 2025-07-10 南京传奇生物科技有限公司 治疗自身免疫疾病的方法
WO2025214438A1 (zh) * 2024-04-10 2025-10-16 浙江纳米抗体技术中心有限公司 结合cd19和/或cd22的抗原结合分子及其用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7846667B2 (ja) * 2020-07-16 2026-04-15 レジェンド バイオテック アイルランド リミテッド Ｃｄ２０結合分子及びその使用
CN114478803B (zh) * 2022-02-11 2023-09-26 北京大学深圳研究生院 一种新型双特异性嵌合抗原受体的构建及其应用
WO2024173607A2 (en) * 2023-02-14 2024-08-22 Evolveimmune Therapeutics, Inc. Combination of bispecific antibodies and chimeric antigen receptor t cells for treatment
WO2025049972A1 (en) * 2023-09-01 2025-03-06 Cargo Therapeutics, Inc. Compositions and methods for immunotherapies

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GB0624500D0 (en) * 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
KR20150029714A (ko) * 2012-07-13 2015-03-18 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 이중특이적 항체의 공-도입에 의한 ｃａｒ 세포의 활성 증강
CA2874083C (en) * 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
CN105384825B (zh) * 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
US11248057B2 (en) * 2016-03-07 2022-02-15 Vib Vzw CD20 binding single domain antibodies
EP4282877A3 (en) * 2016-08-10 2024-02-21 Legend Biotech Ireland Limited Chimeric antigen receptors targeting bcma and methods of use thereof
CN112888709B (zh) * 2018-03-30 2024-10-29 优瑞科生物技术公司 标靶cd22的构建体和其用途
WO2020087116A1 (en) * 2018-10-30 2020-05-07 Peter Maccallum Cancer Institute Bispecific polypeptides for engagement of car expressing immune cells with antigen presenting cells and uses thereof
CN111217908B (zh) * 2019-11-29 2021-07-06 深圳普瑞金生物药业有限公司 Cd22单域抗体、核苷酸序列、试剂盒、car-t病毒载体及car-t细胞
CN110922482B (zh) * 2019-12-25 2021-08-31 源道隆（苏州）医学科技有限公司 可结合cd19的多肽及其应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025146143A1 (zh) * 2024-01-05 2025-07-10 南京传奇生物科技有限公司 治疗自身免疫疾病的方法
WO2025214438A1 (zh) * 2024-04-10 2025-10-16 浙江纳米抗体技术中心有限公司 结合cd19和/或cd22的抗原结合分子及其用途

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IL299865A (en) 2023-03-01
EP4182356A1 (en) 2023-05-24
CA3189531A1 (en) 2022-01-20
EP4182356A4 (en) 2024-11-20
WO2022012681A1 (en) 2022-01-20
KR20230040333A (ko) 2023-03-22
US20230257475A1 (en) 2023-08-17
JP2023546766A (ja) 2023-11-08

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