CN1163579C - Multi-functional and high efficiency composite for washing, sterilizing and used as medicine and its prescription technology - Google Patents

Abstract

The present invention relates to a multifunctional and high-efficiency medicinal composite for washing and sterilizing and a novel compounding technology thereof. The multifunctional and high-efficiency medicinal composite is mainly composed of a quantitative compounded mixture which comprises acid peroxide, neutral peroxide and alkaline peroxide and has stable and effective sterilization effect, a benzoic acid derivative which can complement the peroxide mixture to generate superior sterilization effect, at least four kinds of emulsion and active agents (safer) to perform the functions of dispersing emulsified peroxide molecules, prompting the peroxide molecules to form a stable releasing system, washing and preventing corrosion, phosphate buffer which has pH valve within a certain range and effectively guarantees the stabilization of the emulsion system, and an organic substance which has the medicinal effect of nursing and regulating the skin. The actual effect produced by the (chemical) theoretical design and the compounding technology of the multifunctional and high-efficiency medicinal composite makes the multifunctional and high-efficiency medicinal composite have high application value and good application prospects.

Description

A kind of multifunctional efficient is washed, is disappeared, medicinal compositions and new preparation technology

The present invention relates to wash, sterilization, medicinal, derust and the composition of rust inhibition, the washing of the excellent safety of said composition, sterilization, treatment and the washing of metal oil rust and the effect of anticorrosive metal, being applicable to the washing and the sterilization of family, hospital equipment, foodstuffs industry plant and instrument, simultaneously also is the decontaminant that people's skin and environment is not had harm; Tetter to the people has curative effect preferably simultaneously, aspect the processing of oil rust application is preferably being arranged also at metal.

Most popular in the world at present cleaning and disinfecting articles for use are chlorine-containing compound, quaternary ammonium salt and hydroperoxide kind, and it is higher to have a sterilisation effect, the characteristics that the fungicidal spectrum scope is wider.

But chlorine-containing compound such as clorox, chlorinated isocyanuric acid class, maximum defective is strong and stimulating and corrodibility (to human skin and metal), the smell is awful, less stable.Though Chinese patent CN86104098A can allow chlorinated isocyanuric acid under acidic conditions, and is more stable, but still keep away unavoidable pungency and niff.

Quaternary ammonium salt has significant fungicidal activity, but quaternary ammonium salt is relatively large to the toxic of people's skin, although Chinese patent CN1203513A claims that this compounds is non-irritating relatively, change the frequent thing that in most of the cases should not take place of finding according to compound concentrations and taken place.For addressing toxic side effect and pollution problem, Chinese patent CN1196180A, German Patent 2904217 and United States Patent (USP) 5916568 adopt hydrogen peroxide respectively, make the sterilizing agent of solvent with alcohol, it is good to have sterilisation effect, pungency is low but stable and washing effect is relatively poor, the system function singleness, and applicable surface is in fact narrower.

For addressing this problem, design a kind of novel method and component, make said composition have multifunctional efficient, stability, the more reliable cleaning and disinfecting liquid of security.

An object of the present invention is to provide novel multiple peroxide and cross the quantitative combination of thing, producing widely applicable, pH value is all having efficient, stable sterilization effect at 2-13, and said composition is extremely low to the pungency that people's skin is produced.

One object of the present invention provides a kind of composition that contains benzoic acid derivative, can slowly discharge Whitfield's ointment and acetate in solution, and two kinds of organic bactericides and superoxide interosculate, and produce more excellent sterilization effect.

An object of the present invention is to provide a kind of safe, compound and with the composition of the better emulsifying agents of sterilant affinity such as superoxide, benzoic acid derivative, make said composition have more stable sterilization effect and washability efficiently, environmentally safe.

Another object of the present invention provides a kind of medicinal cleaning composition, contains the conditioning of efficient inorganic, organic bactericide, fungistat and skin protein, affine medicine in the said composition, effectively treats moistening of tetter and normal skin.

One object of the present invention is to provide to have the buffered soln composition of a kind of phosphate buffered to constituting, make the pH value of said composition not be subjected to the influence of extraneous factor to a certain extent, play a part sterilant and emulsifier system and chelated metal ions such as stable peroxide thing.

Another object of the present invention is that a kind of agricultural chemicals emulsion residual on fruit, the vegetables or composition of crystal grain of more effectively dissolving is provided, and the emulsifying agent in the said composition is no matter on structure and had the effect of this reality in nature.

Another object of the present invention provides and contains moistening to metal and promoting agent filming function in a kind of composition said composition with industrial use value, with the pH value of preceding regulator solution a little, just become cleaning and sterilizing Beer Bottle, beverage bottle or metal oil rust cleaning disinfectant.

Hydrogen peroxide is a kind of oxygenant commonly used, can be dissolved at an easy rate in the water, in alcohol, ether, the ester, if in the solvent factor affecting such as metal ion and the fluctuation of pH value are arranged, then causes instability, easily divides the degraded of liberation oxygen.Can form peroxide complex with organic and inorganic thing according to hydrogen peroxide, in the molecule, bonding is to form owing to the hydrogen between electron rich functional group in the complex compounds and the hydrogen peroxide molecule is strong, and the superoxide of formation has improved stabilization of peroxide and purposes to a great extent.The present invention utilizes control superoxide stable outstanding effect of emitting active oxygen and producing with other sterilant optimum combination in water.

Optimization cleaning and disinfecting composition of the present invention contains:

(I) specified proportion of three kinds of superoxide combination:

(a) double salt of persulfuric acid hydrogen salt, raw material is easy to get, and can make by oneself easily, and potassium hydrogen persulfate wherein is best, and its feature is to be 2 in the pH value---very stable in 4 scopes, be a kind of acid superoxide, sterilization is more effective in sour environment.

(b) urea peroxide: it water-soluble splendid, good stability, pH is 6 behind the molten water---between 7,, and have the double properties of urea and hydrogen peroxide, produce conveniently near the pH value of human body, be a kind of near neutral environment the ideal sterilant.It has following advantage:

1. in water, can play the effect that increases tensio-active agent solubility;

2. it with phenylformic acid and derivative thereof, the high carbon acid ester compound is mutually composite can strengthen antibacterial, sterilization effect.

3. itself and and the composite tetter such as keratinization that can treat effectively with skin care of other medicines.

(C) Sodium peroxoborate: it be a kind of in the pH value 8---the superoxide of better fungicidal activity is arranged between 13, and can produce a spot of boric acid under acidic conditions also can sterilization.

The configuration proportion of three kinds of superoxide is 1%---12%: 2%---15%: 1%---12% optimum proportion should be: 2%---8%: 8%---12%: 2%---%, this technology of preparing can guarantee that composition is 2 in the pH value---all has the ideal sterilization effect between 13, becomes the decontaminant that in acidity, neutrality and alkaline environment, can both effectively be used all direction multifunctional.See Table (1)

Decontamination composition of the present invention contains:

(II) safe, emulsifying agent that germ resistance is high and tensio-active agent, according to the superoxide dissolution characteristics of (comprising hydrogen peroxide), my design alternative contains the promoting agent of ester group and ether, and this helps, and sterilant is disperseed, emulsification and keep relatively independent separately stable properties.This composition comprises two kinds of nonionic emulsifier and a kind of amphoterics at least.

(III) this composition includes a kind of organism sterilant:

2-acetoxy-benzoic acid content 0.1%---15%, it can be stablized in emulsion and discharges Whitfield's ointment and acetate, and the three all is better sterilant, it is additional mutually with the superoxide (I), played better sterilization effect, it has significant curative effect to the treatment ringworm of the foot in addition.Best dose is 0.1%---3%.

(IV) this composition contains:

More comprehensive skin moisturizing agent glycerine 1%---10%; Protolysate 1%---5%; Lanolin 1%---5%; Borneol, refrigerant, can itching-relieving action, 0.1%---3%, these materials are nursing skin very significantly, and the skin skin is chapped has curative effect more than 95%.See Table (2).

(V) this composition contains:

Alkali metal pyrophosphate salts class potassium, sodium salt all can, account for 0.5%---5%; Potassium primary phosphate and Sodium phosphate dibasic are 1: 2 by mass ratio---make up at 1: 3, adjust the pH value of solution value 5---between 8.

(VI) this composition comprises a kind of like this purposes:

Make the pH value of solution value 2 by adding sulfuric acid or phosphoric acid---can eliminate the oil rust on the metal in 5 scopes effectively, adding alkali makes the pH value of solution value 8---and 13 can be used as Beer Bottle and beverage bottle clean-out system, respond well, see Table (4) by above technology of preparing, can be used as the purposes of enterprise's cleaning and disinfectings such as family, hospital, foodstuffs industry.(see Table 5 and table 6).

Embodiment 1: a kind of multifunctional efficient decontamination pharmaceutical composition (prescription).

Potassium hydrogen persulfate 2%---8%

Urea peroxide element 3%---12%

Sodium peroxoborate 2%---9%

Sorbitol anhydride oleate polyethers 8%---15%

Sorbitol anhydride oleate 8%---18%

C ₈---C ₁₄Alkyl oxalamide 2%---3%

C ₃---C ₁₆Alkyl betaine 8%---15%

2---acetoxy-benzoic acids 0.1%---3%

Glycerol 1%---5%

Protolysate 1%---5%

Lanolin 1%---5%

Borneol 0.1%---3%

Trisodium phosphate 0.5%---5%

Ethylenediamine tetraacetic acid (EDTA) 0.1%---3%

Phosphate buffered saline buffer is adjusted composition pH:5---between 8

Embodiment 2: comprehensive test data contrast tables (1) such as sterilization

Sample	Concentration	Soak time (minute)	Sterilizing ability	Serology (hepatitis B) dissipation	Applicable pH value scope	Stability	Pungency	To the metal rust preventing ability	To the skin affinity	Influence to environment
											This patent composition	1％	1-5	Well	Good	2- 13	The good actives 6%-8% that only loses more than 700 days	Do not have	Substantially there is not corrosion	Gentle moistening	All degraded is pollution-free
10％	1-5	Good
			20％	1-5	Outstanding
Stoste	1	Efficiently				Efficiently
			The chlorine-containing compound thimerosal	1％	5- 10		Well	Well	8- 11	Differ from loss active matter 30%-50% more than 100 days		Stronger irritating smell	Mild corrosion	Respiratory mucosa festers, pachylosis	Easily form organochlorine and be difficult for degraded
10％	Good	Good				Middle corrosion (has the erosion trace
				20％			Outstanding	Outstanding			(the erosion trace is arranged
Stoste	Efficiently	Outstanding				The severe corrosion
				The one-component Hydrogen Peroxide Disinfection Solution			1％	5- 10			Well		Well			4-7	Good 600 days loss 6%-11%	Do not have	Mild corrosion	Minimal irritation	Biological degradation is good
10％	Good	Good	Slightly
					20％	Outstanding	Outstanding		Little
Stoste	1	Efficiently	Efficiently							Little

Attached:

1, sterilization and serology detect judgement criteria: killing rate is efficient (all killing) more than 99.99%; Be outstanding more than 99.9%; Be good more than 99%; Be good more than 98%.

2, antirust ability test, adopt the different concns of sample, be placed in the beaker, the little iron nail of putting into 10 dryings respectively and weighing with analytical balance, soaked 72 hours, take out, clean, weigh after the drying, the corrosion degree by visual and microscopic examination metallic surface and in conjunction with the difference size of iron nail quality before and after the test estimates the anti-corrosion capability of cleaning disinfectant.

Embodiment 3, and experiment (a) is to people's flesh dermatophytosis and nursing conditioning pilot survey, and the specific aim granting is unit with the family, uses voluntarily, regains 18 people's questionnaires, carries out statistical induction:

Table (2)

Experiment (b)

Test the mensuration of this combination liquid stoste to the antibacterial coefficient of fungi:

Employing is coefficient with the PHENOL 99.8 MIN ((CARBOLIC ACID)), and antibacterial index calculates with cm, measurement result:

Table (3)

To the concrete curative effect of implementing of dermatosis patient and consistent, confirm that combination liquid of the present invention has the good curing effect really to human skin tinea disease by composition of the present invention with the mycostatic practical measurement result of medicine.

Embodiment 4, and slide glass standard greasy dirt washing effect is measured:

The little slide glass of clean microscope is adopted in test, and every group each 10, in the standard greasy dirt, soak 3---5 minutes, press from both sides out, put into washings and soaked 5 minutes, use tweezers agitator treating 2 in washings then---3 minutes, with the aquae destillata flushing, visual and microscopically was observed.

Table (4)

The accurate greasy dirt preparation of affix:

Viscotrol C: white oil: lanolin=1: 1: 1 (weight ratio) adds mixing oil 5g, fourth of the twelve Earthly Branches phosphatidase 11 0g, and carbon black liquid 500ml, 50% ethanol 50ml is diluted to 1500ml.

Embodiment 5: the present composition is removed the test of metal oil rust:

The present composition makes its pH 2 by adding sulfuric acid or phosphoric acid---and between 5, the band brown oil of respectively getting 5 equals in quality little iron nail that becomes rusty is placed in the beaker, puts into test solution, and take out the heat back a little, and visual and microscopically is observed:

Table (5)

The test solution kind	Consumption	The used time	Temperature of reaction	Effect assessment
					The present composition	15％	The 5-10 branch	20-40℃	The Ex-all of brown oil rust, the metallic surface does not have corrosion
Chlorine-containing compound detoxicating liquid	15％	The 5-10 branch	Sump oil removes unclean, and rust is removed, and metal has the erosion line
				A kind of liquid detergent	15％	The 5-10 branch	Can remove the oil rust, but metallic corrosion there is the microetch line

Test demonstrates the oil rust that the present composition can be eliminated metal effectively, and can corrosive nature not arranged to the metallic surface.

Embodiment 6: component of the present invention is as cleaning the Beer Bottle test:

This component adds 5m/l sodium hydroxide solution liquid, and adjust pH is 12---and about 13,20 clean Beer Bottle test white vase debris and pH values thereof are got in the operation of simulation factory washing bottle.Concrete grammar: every clean bottle is fallen to erect 10 seconds kinds measure its drip situation again, wherein half drip refers to flow out in the bottleneck contact palm of the hand circle water, and pH measures and uses thunder magnetic pH-3B acidometer to measure.

Table (6)

The debris situation	The pH value
		Half drip, one drip, two drips do not have drip 67.5% 6% 2% 24.5%	7.05

Debris＜3 droplet wherein, pH value＜7.5 are promptly qualified.

Embodiment 7, the safe performance indexes contrast:

The emulsifying agent that this composition is selected, auxiliary agent, promptly safe to the washing composition remarkable advantages of other similar class.

As: main promoting agent Sorbic Acid sugar acid anhydride oleic acid ester polyethers is the foodstuff additive LD50＞60000mg/kg that uses always, and everyone oral every day of 60g meter of Sorbic Acid sugar acid anhydride acid esters 28 days have no effect, and pungency is extremely low.Trisodium phosphate and sodium phosphate etc. all are foodstuff additive or medical auxiliary agent, and biological degradation does not thoroughly have harm.Say on 26S Proteasome Structure and Function that in addition the nonionic emulsifying agent of this composition also is effective to agricultural chemicals crystal and the residual newborn mark proof of removing on the fruits and vegetables.Therefore can say that this composition is safe to human body and environment, be a kind of promising free of contamination cleaning and disinfecting liquid.

Promoting agent is as emulsifying agent:

(a) the sorbitol anhydride oleate polyethers 5%---and 20%

(b) sorbitol anhydride oleate 5%---and 25%

(c) C ₈---C ₁₄Alkyl oxalamide 1%---5%

This compound has good emulsifying, wetting and anti-corrosion of metal effect.

(d) C ₃---C ₁₆Alkyl betaine 8%---15%

Belong to amphoterics, have two kinds of character of yin, yang ion concurrently, in acidic solution, be cationic, in basic solution, be anionic property, can be shared with positively charged ion, negatively charged ion and nonionogenic tenside, good thermostability, foaming power, wetting and skin condition function are arranged.

Four kinds of best proportionings of promoting agent are: 8%---15%: 8%---and 18%: 2%---3%: 8%---15%, all have no side effect, that have even widely-used as additive in foodstuffs industry, be to use safety environment not to be had the promoting agent of harm.

Claims (8)

1, a kind of multifunctional efficient decontamination composition, it is characterized in that containing potassium hydrogen persulfate double salt, urea peroxide and Sodium peroxoborate are pressed 1%-12%: 2%-15%: effectively there is its fungicidal activity in the wide scope of pH value 2-13 in the system of 1%12% weight proportion.

2, multi-functional decontamination composition as claimed in claim 1, it is characterized in that containing potassium hydrogen persulfate double salt: urea peroxide: Sodium peroxoborate is 2%-8%: 3%-12%: the system of 2%-9% weight proportion.

3, multi-functional decontamination composition as claimed in claim 1 is characterized in that containing a kind of 2-acetoxy-benzoic acid by weight proportion between the 0.1%-5%.

4, multi-functional decontamination composition according to claim 1 is characterized in that containing a kind of 2-acetoxy-benzoic acid by weight proportion between the 0.1%-3%.

5, multi-functional decontamination composition according to claim 1 is characterized in that containing the sorbitol anhydride oleate polyethers: sorbitol anhydride oleate: C ₈-C ₁₄Alkyl oxalamide: C ₃-C ₁₆Alkyl betaine 5%-20%: 5%-25%: 1%-5%: the composite emulsifying system of 5%20% weight proportion.

6, multi-functional decontamination composition according to claim 1 is characterized in that containing the sorbitol anhydride oleate polyethers: sorbitol anhydride oleate: C ₈-C ₁₄Alkyl oxalamide: C ₃-C ₁₆Alkyl betaine is 8%-15%: 8%-18%: 2%-3%: the composite emulsifying system of 8%-15% weight proportion.

7, multi-functional decontamination composition according to claim 1 is characterized in that containing trisodium phosphate 0.5%-5%, ethylenediamine tetraacetic acid (EDTA) 0.1%-3% and adjusting the phosphate buffered saline buffer that said composition pH value reaches 5-8.

8, multi-functional decontamination composition according to claim 1 is characterized in that containing glycerol 1%-5%, protolysate 1%-5%, lanolin 1%-5%, borneol 0.1%-3% weight proportion, formed system.