CN100349514C - Cadaver-preservative fluid and method for producing the same - Google Patents
Cadaver-preservative fluid and method for producing the same Download PDFInfo
- Publication number
- CN100349514C CN100349514C CNB2005101191115A CN200510119111A CN100349514C CN 100349514 C CN100349514 C CN 100349514C CN B2005101191115 A CNB2005101191115 A CN B2005101191115A CN 200510119111 A CN200510119111 A CN 200510119111A CN 100349514 C CN100349514 C CN 100349514C
- Authority
- CN
- China
- Prior art keywords
- parts
- cadaver
- add
- ethanol
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to corpse preservation liquid and a preparation method thereof. The present invention is characterized in that the corpse preservation liquid is prepared from 50% glutaric dialdehyde, aliphatic alcohol polyoxyethylene ether, alcohol, benzalkonium bromide, strong bactericidal anti-corrosion agents, Baimeisha mildew-proof antiseptic, glycerol and deionized water or distilled water. The corpse preservation liquid of the present invention has the characteristics of unique formula and good sterilizing effect and can kill pathogenic entero becteria, pyogenic coccus and pathogenic yeast and kill pathogenic microbes, such as virus, black mutant brood cells of hay bacteria, etc. The corpse preservation liquid has the advantages of broad spectrum, high efficiency, safe corrosion prevention, stable performance, no toxicity, no taste, good biodegradability, no environmental pollution, etc. The preparation method has the advantages of easy acquisition of raw materials, scientific and reasonable preparation, simple method and easy mastering.
Description
Technical field
The present invention relates to cadaver-preservative fluid and preparation method thereof.
Background technology
Existing formalin (Formalin) solution that adopts is dissected used cadaver-preservative fluid as medical human.Oxidation, volatilization, polymerization precipitation can take place in the formaldehyde of the Main Ingredients and Appearance of formalin solution, and concentration is descended, and influence result of use; The formaldehyde of the Main Ingredients and Appearance of formalin solution is poisonous, and the formaldehyde of volatilization is very big to human body harm, particularly respiratory mucosa, eye conjunctiva is stimulated very greatly, and pollutes surrounding environment.
Summary of the invention
It is unique to the purpose of this invention is to provide a kind of prescription, wide spectrum, efficient, safety is anticorrosion, sterilization effect good, stable performance, nontoxic, tasteless, and biodegradable, the cadaver-preservative fluid of environmentally safe; And providing its raw material to be easy to get, formulation science is reasonable, simple and preparation method that grasp easily.
Realize that the technical scheme that the object of the invention adopted is: a kind of cadaver-preservative fluid is characterized in: make by following weight portion: 4～6 parts of 16～24 parts of 50% glutaraldehydes, 0.8～1.2 part of the rare fatty alcohol ether of polyoxy second, 120～180 parts of ethanol, 8～12 parts of benzalkonium bromides, strong disinfecting preservative, hundred mould 650～950 parts of 4～6 parts of fungusproof anti-corrosion agents, 1.6～2.4 parts of glycerine, deionized water or the distilled water that kill.Make by following preferred weight component: 4.5～5.5 parts of 18～22 parts of 50% glutaraldehydes, 0.9～1.1 part of the rare fatty alcohol ether of polyoxy second, 135～165 parts of ethanol, 9～11 parts of benzalkonium bromides, strong disinfecting preservative, hundred mould 730～880 parts of 4.5～5.5 parts of fungusproof anti-corrosion agents, 1.8～2.2 parts of glycerine, deionized water or the distilled water that kill.
The preparation method of cadaver-preservative fluid is: A: remove 2～4 parts of ionized water or distilled water and be heated to 80 ℃, add 0.8～1.2 part of the rare fatty alcohol ether of fusion polyoxy second, cooling; B: remove 40～60 parts of ionized water or distilled water, add 16～24 parts of 50% glutaraldehydes; C: get 40～60 parts of ethanol, add 8～12 parts of benzalkonium bromides; D: get 32～48 parts of ethanol, add 4～6 parts of strong disinfecting preservatives; E: get 32～48 parts of ethanol, add hundred mould 4～6 parts of the fungusproof anti-corrosion agents that kill; F: get 16～24 parts of ethanol, add 1.6～2.4 parts of glycerine; G: with A+B; H: with C+D+E+F; I: with G+H; J: I+ deionized water or distilled water are made for 608～886 parts.
The prescription uniqueness of cadaver-preservative fluid of the present invention, sterilization effect is good, can kill pathogenic entero becteria, pyococcus and pathogenic saccharomycete, and can kill virus, pathogenic microorganism such as withered grass bacterium black mutation brood cell, have wide spectrum, efficient, anticorrosion safely, stable performance, nontoxic, tasteless, and biodegradable, advantages such as environmentally safe; Its preparation method adopts raw material to be easy to get, and formulation science is reasonable, simple and grasp easily.
Embodiment
Below in conjunction with embodiment the present invention is further described.The weight proportion of each raw material of embodiment 1-5 of preparation cadaver-preservative fluid sees the following form.Weight unit price: kg
| Routine number | 50% glutaraldehyde | The rare fatty alcohol ether of polyoxy second | Ethanol | Benzalkonium bromide | The strong disinfecting preservative | The hundred mould fungusproof anti-corrosion agents that kill | Glycerine | Deionized water or distilled water |
| 1 | 16 | 0.8 | 120 | 8 | 4 | 4 | 1.6 | 650 |
| 2 | 18 | 0.9 | 135 | 9 | 4.5 | 4.5 | 1.8 | 730 |
| 3 | 20 | 1 | 150 | 10 | 5 | 5 | 2 | 810 |
| 4 | 22 | 1.1 | 165 | 11 | 5.5 | 5.5 | 2.2 | 880 |
| 5 | 24 | 1.2 | 180 | 12 | 6 | 6 | 2.4 | 950 |
The preparation method of cadaver-preservative fluid is: A: remove 2～4 parts of ionized water or distilled water and be heated to 80 ℃, add 0.8～1.2 part of the rare fatty alcohol ether of fusion polyoxy second, cooling; B: remove 40～60 parts of ionized water or distilled water, add 16～24 parts of 50% glutaraldehydes; C: get 40～60 parts of ethanol, add 8～12 parts of benzalkonium bromides; D: get 32～48 parts of ethanol, add 4～6 parts of strong disinfecting preservatives; E: get 32～48 parts of ethanol, add hundred mould 4～6 parts of F of fungusproof anti-corrosion agent of killing: get 16～24 parts of ethanol, add 1.6～2.4 parts of glycerine; G: with A+B; H: with C+D+E+F; I: with G+H; J: I+ deionized water or distilled water are made for 608～886 parts.
The raw materials used commercially available prod that is of cadaver-preservative fluid of the present invention can be found at public publication.More particularly, wherein 50% glutaraldehyde is produced by chemical industry Co., Ltd of the Supreme Being of Wuhan City section; The rare fatty alcohol ether of polyoxy second (AEO9) is produced by Jilin Chemical Industrial Co. Ltd.; Benzalkonium bromide is produced by Shanghai Volkswagen pharmaceutcal corporation, Ltd; Strong disinfecting preservative (KF-88) is produced by Shaanxi Province designing institute of Petroleum Chemical Engineering Institute; The hundred mould fungusproof anti-corrosion agents that kill are produced by Shanghai Light Industry Inst..
The scope of application of cadaver-preservative fluid of the present invention: the preservation of cadaver sample.Using method: after the cadaver sample perfusion fixes, be soaked in the cadaver-preservative fluid of the present invention.Cadaver-preservative fluid pH value of the present invention is neutral, is fit to 35 ℃～-15 ℃ of temperature ranges.The term of validity 24 months.Preserve at sealing, lucifuge place.
The sample liquid of cadaver-preservative fluid of the present invention is through the desirable effect of 24 months the anticorrosion preservation of cadaver sample acquisition on probation.The corpse structure of preserving is complete naturally, and fixing corpse tissue is moist after dissecting, and the sample color and luster remains intact, and is more pliable and tougher, and it is transparent, nontoxic, tasteless that connective tissue is slightly, efficient corrosion resisting anti-mildew, environmentally safe.
Glutaraldehyde, the benzalkonium bromide effective content assay method of cadaver-preservative fluid of the present invention are provided below.
Glutaraldehyde effective content assay method:
1, (17.5% hydroxylamine hydrochloride adding distil water 75ml dissolves, and adds isopropanol to 500ml, shakes up for preparation 6.5% triethanolamine solution, 0.04% bromophenol blue ethanolic solution and hydroxylamine hydrochloride neutral solution.Add 0.04% bromophenol blue ethanolic solution 15ml, show blue-green) with 6.5% triethanolamine solution titration to solution.Preparation is also demarcated 0.25mol/L sulfuric acid standard liquid.
2, get glutaraldehyde disinfectant sample liquid 10.0ml (concentrated solution of non-disinfection concentration needs 100ml volumetric flask dilution back sampling) and put in the 250ml iodine flask, accurately add 6.5% triethanolamine solution 20.0ml and hydroxylamine hydrochloride neutral solution 25ml, shake up.After leaving standstill reaction 1h, with 0.25mol/L sulfuric acid standard solution titration.Treat that solution shows blue-green, record sulfuric acid solution consumption.Simultaneously, repeat aforesaid operations (blank) with triethanolamine, the hydroxylamine hydrochloride neutral solution that does not contain glutaraldehyde.Repeat to survey 3 times, the mean value of getting 3 times carries out following calculating.
3, because 1mol/L sulfuric acid standard liquid 1ml is equivalent to the 0.1001g glutaraldehyde, therefore can be calculated as follows glutaraldehyde content:
[M is sulfuric acid concentration of standard solution (mol/L); V
1With V
2Be respectively the sulfuric acid standard liquid milliliter number that spends in sample and the blank titration; W is a glutaraldehyde sample milliliter number.]
Benzalkonium bromide effective content assay method:
1, preparation chloroform, 4.3% sodium hydroxide solution, acetate-sodium acetate buffer solution (pH=3.7), 0.05% bromophenol blue indicator.Preparation is also demarcated 0.02mol/L tetraphenylboron sodium standard liquid.
2, get an amount of benzalkonium bromide sample and place the 250ml iodine flask, adding distil water 50ml and sodium hydroxide test solution 1ml shake up, and add bromophenol blue indicator 0.4ml and chloroform 10ml again.Start magnetic stirring apparatus,, when lavender appears in the water layer of solution,, need the control rate of titration, treat that the blueness of chloroform layer disappears, the consumption of record tetraphenylboron sodium standard liquid promptly near terminal point with 0.02mol/L tetraphenylboron sodium standard solution titration.Repeat to survey 3 times, the mean value of getting 3 times carries out following calculating.
3, because 1mol/L tetraphenylboron sodium standard liquid 1ml is equivalent to the 0.3845g benzalkonium bromide, therefore can be calculated as follows benzalkonium bromide content:
[M is tetraphenylboron sodium concentration of standard solution (mol/L); V is the tetraphenylboron sodium standard liquid milliliter number that spends in the titration; W is a benzalkonium bromide sample milliliter number.]
Claims (3)
1. cadaver-preservative fluid is characterized in that: make by following weight portion: 4～6 parts of 16～24 parts of 50% glutaraldehydes, 0.8～1.2 part of the rare fatty alcohol ether of polyoxy second, 120～180 parts of ethanol, 8～12 parts of benzalkonium bromides, strong disinfecting preservative, hundred mould 650～950 parts of 4～6 parts of fungusproof anti-corrosion agents, 1.6～2.4 parts of glycerine, deionized water or the distilled water that kill.
2. cadaver-preservative fluid according to claim 1 is characterized in that: it is made by following weight portion: 4.5～5.5 parts of 18～22 parts of 50% glutaraldehydes, 0.9～1.1 part of the rare fatty alcohol ether of polyoxy second, 135～165 parts of ethanol, 9～11 parts of benzalkonium bromides, strong disinfecting preservative, hundred mould 730～880 parts of 4.5～5.5 parts of fungusproof anti-corrosion agents, 1.8～2.2 parts of glycerine, deionized water or the distilled water that kill.
3. the preparation method of a cadaver-preservative fluid is characterized in that: A: remove 2～4 parts of ionized water or distilled water and be heated to 80 ℃, add 0.8～1.2 part of the rare fatty alcohol ether of fusion polyoxy second, cooling; B: remove 40～60 parts of ionized water or distilled water, add 16～24 parts of 50% glutaraldehydes; C: get 40～60 parts of ethanol, add 8～12 parts of benzalkonium bromides; D: get 32～48 parts of ethanol, add 4～6 parts of strong disinfecting preservatives; E: get 32～48 parts of ethanol, add hundred mould 4～6 parts of the fungusproof anti-corrosion agents that kill; F: get 16～24 parts of ethanol, add 1.6～2.4 parts of glycerine; G: with A+B; H: with C+D+E+F; I: with G+H; J: I+ deionized water or distilled water are made for 608～886 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101191115A CN100349514C (en) | 2005-12-20 | 2005-12-20 | Cadaver-preservative fluid and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101191115A CN100349514C (en) | 2005-12-20 | 2005-12-20 | Cadaver-preservative fluid and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1839691A CN1839691A (en) | 2006-10-04 |
| CN100349514C true CN100349514C (en) | 2007-11-21 |
Family
ID=37029032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005101191115A Expired - Fee Related CN100349514C (en) | 2005-12-20 | 2005-12-20 | Cadaver-preservative fluid and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100349514C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984804B (en) * | 2010-11-03 | 2013-04-17 | 西安医学院 | Corpse preservation solution and preparation method thereof |
| CN105360108A (en) * | 2015-12-16 | 2016-03-02 | 贵阳中医学院 | Specimen preservation fluid good in preservation effect and preparation method of specimen preservation fluid |
| CN106472502A (en) * | 2016-09-21 | 2017-03-08 | 西安乐道生物科技有限公司 | A kind of breeding environment antibacterial and preparation method thereof |
-
2005
- 2005-12-20 CN CNB2005101191115A patent/CN100349514C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 复方戊二醛消毒剂杀菌效果的试验观察 李绥晶，王莉.中国消毒学杂志，第20卷第03期 2003 * |
| 戊二醛与苯扎溴铵联用效果观察 张春霞 等.中国医院药学杂志，第23卷第11期 2003 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1839691A (en) | 2006-10-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101522033B (en) | Disinfectant systems and methods | |
| AU2017272158A1 (en) | Botanical disinfection composition, disinfectant and preparation method thereof | |
| CN112244040B (en) | Hydrogen peroxide silver ion composite disinfectant | |
| CN101032254A (en) | H2O2 air disinfectant with high stability | |
| CN113287627B (en) | Cleaning disinfectant containing potassium hydrogen persulfate compound, and use method and application thereof | |
| CN111685115A (en) | Compound quaternary ammonium salt disinfectant fluid containing traditional Chinese medicine extraction components | |
| CN109777639A (en) | It is a kind of for air-conditioning and the disinfection of general object hard surface and the preparation of hygiene and preparation method thereof | |
| CN113491709A (en) | Multifunctional efficient compound disinfectant and preparation method thereof | |
| CN108684660A (en) | A kind of long-acting bacteriostatic disinfectant containing plants essential oil and preparation method | |
| CN100349514C (en) | Cadaver-preservative fluid and method for producing the same | |
| KR101440375B1 (en) | Disinfectant with synergistic effect and method for manufacturing thereof | |
| CA1039183A (en) | Oxydiacetaldehyde compositions and processes | |
| CN112655704A (en) | Quaternary ammonium salt composite disinfectant | |
| US11279902B2 (en) | Hyperprotonation cleaning, disinfection, and sterilization compositions and methods | |
| CN113100255A (en) | Composite nano-silver pet deodorizing disinfectant and preparation method thereof | |
| CN111567519A (en) | Preparation method of biological disinfectant containing silver ion water | |
| JP5372311B2 (en) | Stabilizer composition based on monoalkyl glycerol ether and aromatic alcohol | |
| CN111226989A (en) | Folium artemisiae argyi composite disinfectant and preparation method thereof | |
| CN101548683B (en) | Liquid disinfectant and method of producing the same | |
| CN1102050A (en) | Quaternary ammonium salt compound disinfectant | |
| CN104886110A (en) | Multipurpose composite cationic surfactant type disinfectant | |
| KR101034283B1 (en) | Wood Antimicrobe Containing Chitosan and Silver Particles and Method Thereof | |
| CN1275406A (en) | Agent for air refreshing and disinfecting | |
| CN1163579C (en) | Multi-functional and high efficiency composite for washing, sterilizing and used as medicine and its prescription technology | |
| CN101743971B (en) | Compound disinfector of peroxyacetic acid and glutaric dialdehyde |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071121 Termination date: 20161220 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |