CN116196353A - Lung-moistening and cough-relieving composition, and preparation method and application thereof - Google Patents
Lung-moistening and cough-relieving composition, and preparation method and application thereof Download PDFInfo
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- CN116196353A CN116196353A CN202310170496.6A CN202310170496A CN116196353A CN 116196353 A CN116196353 A CN 116196353A CN 202310170496 A CN202310170496 A CN 202310170496A CN 116196353 A CN116196353 A CN 116196353A
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Biotechnology (AREA)
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- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a lung-moistening and cough-relieving composition, and a preparation method and application thereof. The preparation method of the lung-moistening and cough-relieving composition comprises the following steps of: soaking pericarpium Citri Junoris in water, inoculating Bacillus bifidus and Bacillus subtilis, and fermenting to obtain pericarpium Citri Junoris fermentation liquid; extracting fructus Siraitiae Grosvenorii and radix Platycodi with water to obtain water extractive solution; mixing the pericarpium Citri Junoris fermentation broth with the water extractive solution. The lung-moistening and cough-relieving composition prepared by the preparation method has the effects of moistening lung, eliminating phlegm and relieving cough.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a lung-moistening and cough-relieving composition, and a preparation method and application thereof.
Background
Cough is a common symptom of the respiratory tract, caused by inflammation, foreign body, physical or chemical irritation of the trachea, bronchus mucosa or pleura. Cough is a nonspecific symptom, is the expression of the body actively coping with diseases, and can relieve the invasion of pathogenic factors to respiratory tract and alleviate the illness; however, too frequent severe coughing can cause congestion and edema of the airway mucosa, leading to respiratory bleeding, even induction of spontaneous pneumothorax, etc. In addition, cough can also spread intra-airway infection; long-term cough stimulation, the cough center can be in a highly excited state permanently; long-term nocturnal cough affects the patient's rest and sleep.
At present, common drugs for relieving cough and reducing sputum in Western medicine include ammonium chloride, necessary sputum and carboxymethyl cysteine, which have remarkable curative effects on inhibiting short-term excessive phlegm symptoms, but cannot effectively relieve cough and reduce sputum. The western medicines are mostly used for diminishing inflammation and are matched with antibiotics for treatment, but the side effects are relatively large, especially antibiotics, the abuse of the antibiotics can cause serious drug resistance, and the cough caused by some chronic bronchitis is not suitable for long-term treatment by using the antibiotics. In recent years, along with the development of society, people are more and more focused on a nourishing channel, and the purposes of conditioning bodies and preventing diseases through diet therapy are more and more hoped.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the invention provides a lung-moistening and cough-relieving composition and a preparation method and application thereof.
In a first aspect of the invention, there is provided a method of preparing a lung moistening and cough relieving composition comprising the steps of:
soaking pericarpium Citri Junoris in water, inoculating Bacillus bifidus and Bacillus subtilis, and fermenting to obtain pericarpium Citri Junoris fermentation liquid; extracting fructus Siraitiae Grosvenorii and radix Platycodi with water to obtain water extractive solution; mixing the orange peel fermentation liquor with the water extract to obtain the compound.
The invention adopts a microbial fermentation method to extract the orange peel, and the active ingredients (synephrine and D-limonene) in the orange peel are beneficial to being dissociated after fermentation, and the fermented fermentation liquid contains a plurality of micromolecular substances, thereby being more beneficial to human body absorption. If ethyl acetate is adopted to extract orange peel, the process is complex, the yield is low, and industrial production is difficult to carry out. If orange peel is extracted by an acid-alkali-enriched or alcohol precipitation ammonia washing method, the method is not suitable for food production.
According to some embodiments of the invention, the ratio of orange peel to water in solid to liquid during the soaking process is 1g: 15-30 mL;
further, the soaking temperature is 20-50 ℃;
further, the soaking time is 0.5-2 h.
According to some embodiments of the invention, the total concentration of the bifidobacteria and the bacillus subtilis in the fermentation system of the orange peel is (4-10) ×10 4 CFU/mL；
Further, the number ratio of the bifidobacteria to the bacillus subtilis is 1-4: 1, preferably 3:1.
according to some embodiments of the invention, the temperature of the fermentation is 35-37 ℃;
further, the fermentation time is 10-14 h.
According to some embodiments of the invention, in the water extraction process, the total solid-to-liquid ratio of the momordica grosvenori, the platycodon grandiflorum and the water is 1g: 15-30 mL;
further, the temperature of the water extraction is 80-100 ℃;
further, the water extraction time is 0.5-2 h.
According to some embodiments of the invention, the mass ratio of the orange peel, the momordica grosvenori and the platycodon root is 20-30: 15-25: 15-25.
The main components of the orange peel for relieving cough and reducing sputum are synephrine and D-limonene, and the alkaloid synephrine has stronger functions of dilating trachea and bronchus; the volatile oil mainly contains D-limonene, acts on respiratory tract mucous membrane and makes it secrete mucus to relieve bronchospasm; momordica grosvenori and platycodon grandiflorum serve as ministerial drugs. The addition and deletion of the components or the change of the dosage of the components can influence the lung moistening and cough relieving effects of the composition.
According to some embodiments of the invention, the mixing further comprises adding at least one of honey, maltodextrin, gelatin powder, sweetener;
further, the mass ratio of the honey to the orange peel is 20-30: 20-30 parts;
further, the mass ratio of the maltodextrin to the orange peel is 10-15: 20-30 parts;
further, the mass ratio of the rubber powder to the orange peel is 5-10: 20-30 parts;
further, the mass ratio of the sweetener to the orange peel is 1-2: 20-30 parts.
According to some embodiments of the invention, the gum powder is selected from at least one of carrageenan, konjaku flour, xanthan gum.
According to some embodiments of the invention, the sweetener is selected from at least one of mogroside, sucralose.
In a second aspect of the present invention, there is provided a lung-moistening and cough-relieving composition prepared by the above preparation method.
According to some embodiments of the invention, the raw materials for preparing the lung-moistening and cough-relieving composition comprise the following components in parts by weight:
20-30 parts of orange peel;
15-25 parts of fructus momordicae;
15-25 parts of platycodon grandiflorum.
According to some embodiments of the present invention, the raw materials for preparing the lung-moistening and cough-relieving composition further include at least one of the following (I) to (IV) in parts by weight:
(I) 20-30 parts of honey;
(II) maltodextrin 10-15 parts;
(III) 5-10 parts of rubber powder;
(IV) sweetener 1-2 parts.
According to some embodiments of the invention, the lung-moistening and cough-relieving composition is in the form of an ointment.
In a third aspect, the invention provides an application of the lung-moistening and cough-relieving composition in preparing a lung-moistening and cough-relieving medicament.
The beneficial effects are that:
the preparation raw materials are simple, and the active ingredients of the medicine are derived from orange peel, fructus momordicae and platycodon grandiflorum; the effective components in the orange peels are fully extracted by adopting a microbial fermentation method, and the lung-moistening and cough-relieving composition is prepared by matching the water extract of the momordica grosvenori with the effects of clearing heat, moistening lung, smoothing intestine and relaxing bowels and the water extract of the platycodon grandiflorum with the effects of moistening lung, promoting the production of body fluid and tonifying spleen and stomach. The composition has effects of moistening lung, eliminating phlegm, and relieving cough; and has better taste and flavor, which is beneficial to improving the compliance of patients.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Detailed Description
The conception and the technical effects produced by the present invention will be clearly and completely described in conjunction with the embodiments below to fully understand the objects, features and effects of the present invention. It is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments, and that other embodiments obtained by those skilled in the art without inventive effort are within the scope of the present invention based on the embodiments of the present invention.
The experimental methods in the following examples are conventional methods unless otherwise specified. The raw materials and reagent materials used in the examples below are all commercially available products unless otherwise specified.
Example 1
This example provides a lung-moistening and cough-relieving composition, the raw materials for its preparation are shown in table 1.
The preparation method of the lung-moistening and cough-relieving composition in the embodiment is as follows:
(1) Cleaning pericarpium Citri Junoris, cutting, cleaning fructus Siraitiae Grosvenorii and radix Platycodi, and pulverizing into pieces of about 1.5mm×1.5 mm;
(2) Soaking pericarpium Citri Junoris in 20 times of water at 40deg.C for 1 hr for swelling, pulping;
(3) Adding maltodextrin into orange peel pulp, inoculating Bacillus bifidus and Bacillus subtilis (total inoculation concentration of 8X10) 4 CFU/mL, the quantitative ratio of the CFU to the CFU/mL is 3: 1) Fermenting at 37 ℃ for 12 hours;
(4) Heating to boil after fermentation, inactivating strain, and filtering to obtain pericarpium Citri Junoris fermentation liquid;
(5) Adding water 20 times of the total amount of fructus Siraitiae Grosvenorii and radix Platycodi, extracting at 90deg.C for 40 min, and filtering to obtain extractive solution;
(6) Adding appropriate amount of water into rubber powder, sweetener and Mel, decocting to 90deg.C, cooling to 80deg.C, and adding the extractive solution and pericarpium Citri Junoris fermentation liquid;
(7) Filling, sealing and sterilizing to obtain the ointment product.
Example 2
This example provides a lung-moistening and cough-relieving composition, the raw materials for its preparation are shown in table 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1.
Example 3
This example provides a lung-moistening and cough-relieving composition, the raw materials for its preparation are shown in table 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1.
Example 4
This example provides a lung-moistening and cough-relieving composition, the raw materials for its preparation are shown in table 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1.
Example 5
This example provides a lung-moistening and cough-relieving composition, the raw materials for its preparation are shown in table 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1.
Example 6
This example provides a lung-moistening and cough-relieving composition, which is prepared from the same raw materials as those in example 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1, wherein the difference is that: in the step (3), the total inoculation concentration of the bifidobacterium and the bacillus subtilis is 1 multiplied by 10 4 CFU/mL, the quantitative ratio of the CFU to the CFU/mL is 3:1。
example 7
This example provides a lung-moistening and cough-relieving composition, which is prepared from the same raw materials as those in example 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1, wherein the difference is that: in the step (3), the total inoculation concentration of the bifidobacterium and the bacillus subtilis is 8 multiplied by 10 4 CFU/mL, the quantitative ratio of the CFU to the mL is 1:3.
example 8
This example provides a lung-moistening and cough-relieving composition, which is prepared from the same raw materials as those in example 1.
The preparation method of the lung-moistening and cough-relieving composition of the embodiment refers to the process in the embodiment 1, wherein the difference is that: in the step (3), fermentation is carried out at 45 ℃ for 8 hours.
Comparative example 1
This example provides a lung-moistening and cough-relieving composition, which is prepared from the same raw materials as those in example 1.
The preparation method of the lung-moistening and cough-relieving composition in the embodiment is as follows:
(1) Cleaning pericarpium Citri Junoris, cutting, cleaning fructus Siraitiae Grosvenorii and radix Platycodi, and pulverizing into pieces of about 1.5mm×1.5 mm;
(2) Soaking pericarpium Citri Junoris in 20 times of water at 40deg.C for 1 hr for swelling, pulping, adding maltodextrin into pericarpium Citri Junoris pulp, soaking for 12 hr, and filtering to obtain pericarpium Citri Junoris pulp;
(3) Adding water 20 times of the total amount of fructus Siraitiae Grosvenorii and radix Platycodi, extracting at 90deg.C for 40 min, and filtering to obtain extractive solution;
(4) Adding appropriate amount of water into rubber powder, sweetener and Mel, decocting to 90deg.C, cooling to 80deg.C, and adding the extractive solution and pericarpium Citri Junoris slurry;
(5) Filling, sealing and sterilizing to obtain the ointment product.
Comparative example 2
This example provides a lung-moistening and cough-relieving composition, which is prepared from the same raw materials as those in example 1.
The method of preparing the lung-moistening and cough-relieving composition of this example refers to the procedure of example 1Row, the difference is: inoculating only Bifidobacterium at an inoculation concentration of 8X10 4 CFU/mL。
Table 1 (weight portions)
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Orange peel | 22 | 26 | 20 | 10 | 25 |
| Momordica grosvenori | 20 | 18 | 15 | 35 | 20 |
| Radix Platycodi | 20 | 16 | 25 | 35 | 25 |
| Honey | 20 | 20 | 20 | 10 | 20 |
| Maltodextrin | 10 | 12 | 10 | 4 | / |
| Carrageenan gum | 2 | 5 | 3 | 2 | 3 |
| Konjaku flour | 2 | / | 2 | 2 | 2 |
| Xanthan gum | 2 | 2 | 3 | 1 | 3 |
| Mogroside | 1 | 1 | 1 | 0.5 | 1 |
| Sucralose | 1 | / | 1 | 0.5 | 1 |
Test case
1. Determination of the content of synephrine and D-limonene
The content change of synephrine and D-limonene before and after microbial fermentation of orange peel pulp was measured by HPLC method in each example and comparative example, and the extraction rate was calculated, and the test results are shown in Table 2.
TABLE 2 content and extraction yield of synephrine and D-limonene in orange peel fermentation broth after microbial fermentation
| Synephrine (mg/mL) | Extraction yield (%) | D-limonene (mg/mL) | Extraction yield (%) | |
| Example 1 | 0.82 | 96.5 | 2.45 | 94.2 |
| Example 2 | 0.77 | 90.6 | 1.94 | 74.6 |
| Example 3 | 0.84 | 98.8 | 2.38 | 91.5 |
| Example 4 | 0.68 | 80.0 | 1.77 | 68.1 |
| Example 5 | 0.74 | 87.1 | 1.74 | 66.9 |
| Example 6 | 0.71 | 83.5 | 1.81 | 69.6 |
| Example 7 | 0.69 | 81.2 | 1.89 | 72.7 |
| Example 8 | 0.68 | 80.0 | 1.80 | 69.2 |
| Comparative example 1 | 0.37 | 43.5 | 1.24 | 47.7 |
| Comparative example 2 | 0.51 | 60.0 | 1.44 | 55.4 |
2. Cough effect and flavor mouthfeel test
The lung-moistening and cough-relieving compositions prepared in the examples 1 to 8 and the comparative examples 1 and 2 were subjected to a test eating test.
110 subjects with cough symptoms and difficult sputum excretion were randomly selected, and the subjects were aged 25-35 years, had no underlying disease, and were equally divided into 11 groups, examples 1-8, comparative examples 1, 2, and a blank group. Each experimental group was used with 1 part (5 g) of the lung-moistening and cough-relieving ointment, the control group was not taken, the experimental period was 15 days, and cough conditions, sputum expectoration conditions and flavor and taste evaluation of the lung-moistening and cough-relieving ointment were observed and recorded for each experimental group and control group subject. Wherein all subjects maintained their original dietary habits during the experimental period. The test results are shown in Table 3 below.
TABLE 3 Table 3
While the embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. Furthermore, embodiments of the invention and features of the embodiments may be combined with each other without conflict.
Claims (10)
1. A method for preparing a lung-moistening and cough-relieving composition, which is characterized by comprising the following steps of:
soaking pericarpium Citri Junoris in water, inoculating Bacillus bifidus and Bacillus subtilis, and fermenting to obtain pericarpium Citri Junoris fermentation liquid; extracting fructus Siraitiae Grosvenorii and radix Platycodi with water to obtain water extractive solution; mixing the orange peel fermentation liquor with the water extract to obtain the compound.
2. The method according to claim 1, wherein the ratio of orange peel to water in solid-to-liquid ratio during the soaking is 1g: 15-30 mL, the soaking temperature is 20-50 ℃ and the soaking time is 0.5-2 h.
3. The method according to claim 1, wherein the total concentration of the bifidobacterium and the bacillus subtilis in the fermentation system of the orange peel is (4-10) ×10 4 CFU/mL；
Preferably, the number ratio of the bifidobacteria to the bacillus subtilis is 1-4: 1.
4. the method according to claim 1, wherein the fermentation temperature is 35 to 37 ℃ and the fermentation time is 10 to 14 hours.
5. The preparation method according to claim 1, wherein in the water extraction process, the total solid-to-liquid ratio of the momordica grosvenori to the platycodon grandiflorum to the water is 1g: 15-30 mL, wherein the temperature of the water extraction is 80-100 ℃, and the time of the water extraction is 0.5-2 h.
6. The preparation method of claim 1, wherein the mass ratio of orange peel, fructus momordicae and platycodon grandiflorum is 20-30: 15-25: 15-25.
7. The method according to claim 1, wherein the mixing further comprises adding at least one of honey, maltodextrin, gum powder, and sweetener;
preferably, the mass ratio of the honey to the orange peel is 20-30: 20-30, wherein the mass ratio of maltodextrin to orange peel is 10-15: 20-30, wherein the mass ratio of the rubber powder to the orange peel is 5-10: 20-30, wherein the mass ratio of the sweetener to the orange peel is 1-2: 20-30 parts;
more preferably, the gum powder is at least one selected from carrageenan, konjaku flour and xanthan gum; the sweetener is at least one selected from mogroside and sucralose.
8. The lung-moistening and cough-relieving composition prepared by the preparation method of any one of claims 1 to 7.
9. The lung-moistening and cough-relieving composition of claim 8, wherein the formulation of the lung-moistening and cough-relieving composition is an ointment.
10. The use of a lung-moistening and cough-relieving composition as claimed in claim 8 or 9 for the manufacture of a medicament for moistening lung and relieving cough.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103421712A (en) * | 2013-07-29 | 2013-12-04 | 内蒙古和美科盛生物技术有限公司 | Bifidobacterium animalis and bacillus subtilis for solid fermentation of probiotics in field of feed additives |
| CN106820022A (en) * | 2016-12-31 | 2017-06-13 | 蚌埠清菲农业科技有限公司 | One kind fermentation orange peel sauce powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103421712A (en) * | 2013-07-29 | 2013-12-04 | 内蒙古和美科盛生物技术有限公司 | Bifidobacterium animalis and bacillus subtilis for solid fermentation of probiotics in field of feed additives |
| CN106820022A (en) * | 2016-12-31 | 2017-06-13 | 蚌埠清菲农业科技有限公司 | One kind fermentation orange peel sauce powder |
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