CN107496558B

CN107496558B - Composition for treating cough and application thereof

Info

Publication number: CN107496558B
Application number: CN201710742350.9A
Authority: CN
Inventors: 晏仁义; 李赫宇; 张东星; 王磊; 胡丹; 于滢慧
Original assignee: Tianjin Kangshi Biotechnology Co ltd
Current assignee: Tianjin Kangshi Biotechnology Co ltd
Priority date: 2017-08-25
Filing date: 2017-08-25
Publication date: 2020-09-22
Anticipated expiration: 2037-08-25
Also published as: CN107496558A

Abstract

The invention relates to functional food or health food, and particularly discloses a composition for treating cough and application thereof. The composition comprises the following components in parts by weight: 5-20 parts of mulberry leaf, 5-20 parts of sweet almond, 10-30 parts of loquat leaf, 5-20 parts of perilla stem, 5-20 parts of platycodon root, 5-20 parts of dried orange peel, 5-30 parts of burdock root, 5-20 parts of Chinese olive and 5-10 parts of raw liquorice. The components are matched and shared, the cough-relieving tea achieves the effect of treating cough by clearing away lung-heat, moistening dryness, tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, and is suitable for people who have cough problems caused by wind-heat type common cold and lung-heat type dry cough. Compared with the conventional cough treatment medicines, the composition has the characteristics of short administration period, good curative effect, difficult repeated attack, no side effect and the like when being applied to the treatment of cough diseases.

Description

Composition for treating cough and application thereof

Technical Field

The invention relates to functional food or health food, in particular to a composition for treating cough and application thereof.

Background

Cough is a protective respiratory reflex action of a human body for removing secretions or foreign matters in the respiratory tract, but severe long-term cough can cause respiratory tract bleeding, persistent severe cough can affect rest, physical strength is easy to be consumed, elastic tissues of alveolar walls can be damaged, and emphysema is induced. The traditional Chinese medicine considers that cough is caused by external six excesses and internal injury of internal organs, and has the syndrome of sound and phlegm caused by affecting the lung. The book Su Wen Bing Zhi Qi Yi Bao Ming Ji (Collection of Qi Yi Bao Ming Ji for Su Wen Bing) written: cough means no phlegm but sound, lung qi impairment but unclear; cough is silent with phlegm, and spleen is damp and moves with phlegm. Cough is a sound due to phlegm, which affects the lung qi and the spleen dampness, and also affects the lung due to exogenous pathogenic factors or internal injury of the viscera. Western medicine thinks that cough can be divided into acute and chronic types, and acute cough is mainly caused by virus, mycoplasma or bacterial infection, but chronic cough causes relatively complicated disease, and treatment cycle is long, easy to repeat, difficult to cure. In the prior art, western medicine takes effect quickly, but has large side effect and easy relapse of illness.

Therefore, it is highly desirable to provide a drug for treating cough, which has the advantages of obvious curative effect, quick response, difficult recurrence and no toxic or side effect.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a composition for treating cough and application thereof.

In order to realize the purpose of the invention, the technical scheme of the invention is as follows:

the invention firstly provides a composition for treating cough, which comprises the following components in parts by weight: 5-20 parts of mulberry leaf, 5-20 parts of sweet almond, 10-30 parts of loquat leaf, 5-20 parts of perilla stem, 5-20 parts of platycodon root, 5-20 parts of dried orange peel, 5-30 parts of burdock root, 5-20 parts of Chinese olive and 5-10 parts of raw liquorice.

Preferably, the composition comprises the following components in parts by weight: 5-10 parts of mulberry leaf, 5-10 parts of sweet almond, 10-20 parts of loquat leaf, 5-10 parts of perilla stem, 5-10 parts of platycodon root, 5-10 parts of dried orange peel, 10-20 parts of burdock root, 5-10 parts of Chinese olive and 5-8 parts of raw liquorice.

More preferably, the composition comprises the following components in parts by weight: 10 parts of mulberry leaf, 10 parts of sweet almond, 15 parts of loquat leaf, 10 parts of perilla stem, 10 parts of platycodon root, 10 parts of dried orange peel, 15 parts of burdock root, 10 parts of Chinese olive and 5 parts of raw liquorice.

In the above composition:

the weight parts can be the weight units known in the medical field such as mu g, mg, g, kg, and the like, and can also be multiples thereof such as 1/10, 1/100, 10, 100, and the like.

The invention also provides application of the composition in preparing functional food or health-care food for treating cough.

The functional food or health food can be made into conventional dosage forms in the field of medicine, such as granule, tablet, capsule, soft extract, beverage, etc.

Optionally/preferably, the dosage form is a granule, and comprises the following components in parts by weight: 5-20 parts of mulberry leaf, 5-20 parts of sweet almond, 10-30 parts of loquat leaf, 5-20 parts of perilla stem, 5-20 parts of platycodon root, 5-20 parts of dried orange peel, 5-30 parts of burdock root, 5-20 parts of Chinese olive, 5-10 parts of raw liquorice, 50-100 parts of prebiotics and 2-10% of binder (the dosage is 2-10% of the total weight of other components).

Preferably, the granules comprise the following components in parts by weight: 5-10 parts of mulberry leaf, 5-10 parts of sweet almond, 10-20 parts of loquat leaf, 5-10 parts of perilla stem, 5-10 parts of platycodon root, 5-10 parts of dried orange peel, 10-20 parts of burdock root, 5-10 parts of Chinese olive, 5-8 parts of raw liquorice, 50-80 parts of prebiotics and 2-8% of binder (the dosage is 2-8% of the total weight of other components).

More preferably, the granules comprise the following components in parts by weight: 10 parts of mulberry leaf, 10 parts of sweet almond, 15 parts of loquat leaf, 10 parts of perilla stem, 10 parts of platycodon grandiflorum, 10 parts of dried orange peel, 15 parts of burdock root, 10 parts of Chinese olive, 5 parts of raw liquorice, 60 parts of prebiotics and 5% of binder (the dosage is 5% of the total weight of other components).

Wherein the prebiotics (Probiotics) is isomaltooligosaccharide, fructo-oligosaccharide or xylo-oligosaccharide. In a specific embodiment of the present invention, the isomaltooligosaccharide is obtained from Tianjin Yibeiyuan Natural products technology, Inc., and has an isomaltooligosaccharide content of more than 80%.

Wherein the binder is 80% (volume fraction) alcohol.

The invention further provides a preparation method of the granules, which comprises the following steps:

1) pulverizing and sieving isomaltooligosaccharide, selecting fine powder of 60 meshes, weighing extracts of dried folium Mori, semen Pruni Armeniacae, folium Eriobotryae, caulis Perillae, radix Platycodi, pericarpium Citri Tangerinae, radix Arctii, fructus Canarii albi and Glycyrrhrizae radix according to a certain proportion, pulverizing and sieving, mixing fine powder of 60 meshes with fine powder of isomaltooligosaccharide;

2) adding 80% alcohol as binder into the mixed fine powder, making into 60 mesh granule, drying at 50 deg.C for 60 min, and packaging.

The raw materials or reagents involved in the invention are all common commercial products, and the operations involved are all routine operations in the field unless otherwise specified.

The above-described preferred conditions may be combined with each other to obtain a specific embodiment, in accordance with common knowledge in the art.

The invention has the beneficial effects that:

1. the invention takes mulberry leaf, sweet almond, loquat leaf, perilla stem, balloonflower root, dried orange peel, burdock root, Chinese olive and raw licorice as main raw materials, makes various components reasonably combined and used together, achieves the effect of treating cough by clearing away the lung-heat and moistening dryness, tonifying spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, and is suitable for people who have cough problems caused by wind-heat type common cold and lung-heat type dry cough.

2. The granule provided by the invention is convenient to carry, quick to take, moderate in taste and special in fragrance.

3. Experiments show that the cough of volunteers taking the composition and the granules provided by the invention is obviously improved.

Compared with the conventional cough treatment medicines, the composition has the characteristics of short administration period, good curative effect, difficult repeated attack, no side effect and the like when being applied to the treatment of cough diseases.

Detailed Description

Preferred embodiments of the present invention will be described in detail with reference to the following examples. It is to be understood that the following examples are given for illustrative purposes only and are not intended to limit the scope of the present invention. Various modifications and alterations of this invention will become apparent to those skilled in the art without departing from the spirit and scope of this invention.

Materials, reagents and the like used in the following examples are commercially available unless otherwise specified.

Example 1

1. Raw materials

10 parts of mulberry leaf, 10 parts of sweet almond, 15 parts of loquat leaf, 10 parts of perilla stem, 10 parts of platycodon grandiflorum, 10 parts of dried orange peel, 15 parts of burdock root, 10 parts of Chinese olive, 5 parts of raw liquorice, 60 parts of isomaltooligosaccharide and 5% of binder (the dosage is 5% of the total weight of other components).

2. Preparation method

Example 2

The difference between the present example and example 1 is that the raw materials are: 5 parts of mulberry leaf, 10 parts of sweet almond, 20 parts of loquat leaf, 5 parts of perilla stem, 5 parts of platycodon grandiflorum, 10 parts of dried orange peel, 10 parts of burdock root, 5 parts of Chinese olive, 8 parts of raw liquorice, 50 parts of isomaltooligosaccharide and 5% of binder (the dosage is 5% of the total weight of other components).

Example 3

The difference between the present example and example 1 is that the raw materials are: 20 parts of mulberry leaf, 20 parts of sweet almond, 10 parts of loquat leaf, 5 parts of perilla stem, 5 parts of platycodon grandiflorum, 20 parts of dried orange peel, 30 parts of burdock root, 5 parts of Chinese olive, 5 parts of raw liquorice, 100 parts of isomaltooligosaccharide and 5% of binder (the dosage is 5% of the total weight of other components).

Comparative example 1

The composition is administered 3 times a day, 5mg per adult, according to the instructions of Kekemin (Wawei pharmaceutical Co., Ltd., Jilin province).

Experimental example 1

This experimental example was used to compare the efficacy of examples 1-3 and comparative example 1 in treating cough.

1. Selecting a crowd:

selecting patients with cough of 25-70 years old, and 50 people of male and female.

2. Diagnostic criteria

Wind-heat affecting the lung: cough with coarse breath, sticky white or yellow sputum, pharyngalgia, hoarseness, fever, slight aversion to wind-cold, and slight thirst; red tongue tip, thin white or yellow coating, and superficial and rapid pulse;

dryness hurts the lung: dry cough with little sputum, uncomfortable expectoration, dry nasopharynx and dry mouth; red tongue tip, thin and yellow coating, little fluid, thready and rapid pulse;

phlegm-heat obstructing the lung: cough with thick breath, thick and yellow sputum, feverish dysphoria with smothery sensation and dry mouth; a red tongue with a yellow and greasy coating and a slippery and rapid pulse.

3. Experimental methods

Dividing 100 patients into 5 groups of 12 patients, respectively taking 5g of the composition granules of examples 1-3 in groups 1-3, and taking with 50ml of warm water twice a day after meals; group 4, taking medicine according to the Kekemin instruction, and taking the medicine as a comparison group; group 5 was no drug and was a blank control group; the administration period is 5 days.

4. Assessment of efficacy

And (3) curing: cough and sputum disappear or cough and sputum do not appear basically day and night.

The effect is shown: the cough frequency is obviously reduced, and the sputum volume is obviously reduced.

The method has the following advantages: a reduced number of coughs or a reduced amount of sputum.

And (4) invalidation: cough and sputum did not improve or aggravate.

5. The results are shown in Table 1

TABLE 1

As can be seen from the healing results in the table, the patients in the placebo group rarely treated cough by their own self-healing ability for a treatment period of 5%, and drug therapy is an effective treatment. The effect of treating cough of example 1 of the present invention was not inferior to that of the comparative example. The composition of the invention has the function of treating cough, and the patient taking the composition of the embodiment 1 does not have the adverse reactions of sleepiness, body fatigue and the like of the patient in the comparative example. The composition of the invention is safe and effective, has no side effect and has the advantages. The examples 2 and 3 also show better effect of treating cough, and the function is slightly worse than that in the example 1 due to the mixture ratio difference of the traditional Chinese medicine components. Thus, example 1 was determined to be the most preferred embodiment.

Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The composition for treating cough is characterized by comprising the following components in parts by weight: 10 parts of mulberry leaf, 10 parts of sweet almond, 15 parts of loquat leaf, 10 parts of perilla stem, 10 parts of platycodon grandiflorum, 10 parts of dried orange peel, 15 parts of burdock root, 10 parts of Chinese olive, 5 parts of raw liquorice and 60 parts of prebiotics, wherein the prebiotics are isomaltooligosaccharide, fructo-oligosaccharide or xylo-oligosaccharide.

2. Use of the composition of claim 1 for preparing a functional food or health food having an antitussive effect.

3. A pharmaceutical formulation for the treatment of cough comprising or prepared from the composition of claim 1.

4. The formulation of claim 3, wherein the formulation is a granule.

5. The preparation of claim 4, wherein the raw materials of the granules comprise the following components in parts by weight: 10 parts of mulberry leaf, 10 parts of sweet almond, 15 parts of loquat leaf, 10 parts of perilla stem, 10 parts of platycodon grandiflorum, 10 parts of dried orange peel, 15 parts of burdock root, 10 parts of Chinese olive, 5 parts of raw liquorice and 60 parts of prebiotics; and 5% by weight of a binder based on the total weight of the aforementioned components.