CN102836254A - Medicine composition for treating infectious bursal diseases of chickens and preparation method thereof - Google Patents
Medicine composition for treating infectious bursal diseases of chickens and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating the infectious bursal diseases of chickens and a preparation method thereof. The medicine composition for treating the infectious bursal diseases of the chickens is prepared by the following traditional Chinese medicines according to a certain proportion in parts by weight: 40 to 80 parts of dandelion, 60 to 100 parts of isatis leaf, 160 to 240 parts of radix isatidis, 40 to 80 parts of honeysuckle, 20 to 60 parts of baikal skullcap root, 20 to 60 parts of yellow-corktree bark, 20 to 60 parts of wrinkled giant hyssop, 60 to 120 parts of gypsum, 40 to 80 parts of licorice, 25 to 40 parts of organic acid, 40 to 60 parts of weak base, 3 to 6 parts of lubricant and 5 to 10 parts of sweetening agent. The preparation formulation of the composition is effervescent granules. The preparation method comprises the following steps of: pulverizing the bulk drugs, adding water, decocting, carrying out alcohol precipitation on filtrate, concentrating after recovering ethanol from supernatant liquid, and drying so as to obtain an extract; and dividing the extract into two equal parts, adding the organic acid, the lubricant and the sweetening agent into one part so as to prepare acid granules, drying for standby application, adding the weak base, the lubricant and the sweetening agent into the other part so as to prepare alkali granules, drying for standby application, then mixing the two kinds of granules evenly, granulating and packaging so as to obtain the medicine composition for treating the infectious bursal diseases of the chickens. Various medicines in the medicine composition for treating the infectious bursal diseases of the chickens are combined for use. The medicine composition for treating the infectious bursal diseases of the chickens has the effects of invigorating qi, strengthening the spleen, nourishing yin, clearing heat, cooling blood, removing toxic materials and the like. The effect of treating the infectious bursal diseases of the chickens by utilizing the medicine composition for treating the infectious bursal diseases of the chickens is obvious; and moreover, the cost is low, and the toxic or side effect is small.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition that is used to treat infectious bursal disease and preparation method thereof, belong to field of veterinary.
Background technology
Infectious bursal disease (IBD) is a kind of acute, the height contagious disease that is caused 2-6 chickling in age in week by infectious bursa diseases virus.With fabricius bursa swelling, hemorrhage, downright bad, chest muscle, lower limb flesh are hemorrhage, and glandular stomach, muscular stomach intersection strip is hemorrhage is characteristic.Clinical manifestation is lassitude, anorexia, indirect diarrhoea, tremble and severe weak, cut open inspection change, renal tubules urate deposition hemorrhage and fabricius bursa enlargement with dehydration, skeletal muscle, hemorrhage be characteristic.The harm of primary disease mainly is humoral immunization maincenter--the fabricius bursa of virus infraction chicken, and the lymphocyte generation of chicken bursa is damaged, and reduces maybe can not produce immunoglobulin, causes immunodeficiency disease.
Because the generation of IBDV variant, the continuous appearance of various highly virulent strains, and part attenuated vaccine immunity effect is not ideal enough, immune programme for children is improper etc., and reason causes immuning failure is so often meet the breaking out of IBD, popular at veterinary clinic.Can treat though use anti-IBDV hyper-immune serum and high immunity yolk antibody, the two all had the hidden danger of propagating other infectiousness cause of diseases, and the Ministry of Agriculture has prohibited the production and the clinical use of hyper-immune serum and yolk antibody in 2004.Traditional veterinary of motherland is of extensive knowledge and profound scholarship, the emphasis Cause & Symptom Solution of curing the disease.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition that is used to treat infectious bursal disease and preparation method thereof.
In order to realize above purpose; The present invention adopts following technical scheme to realize; A kind of pharmaceutical composition that is used to treat infectious bursal disease; Comprise following weight portion crude drug: Herba Taraxaci 40-80 part, Folium Isatidis 60-100 part, Radix Isatidis 160-240 part, Flos Lonicerae 40-80 part, Radix Scutellariae 20-60 part, Cortex Phellodendri 20-60 part, Herba Pogostemonis 20-60 part, Gypsum Fibrosum 60-120 part, Radix Glycyrrhizae 40-80 part, organic acid 25-40 part, weak base 40-60 part, lubricant 3-6 part, sweeting agent 5-10 part.
A kind of pharmaceutical composition that is used to treat infectious bursal disease prepares by following concrete operations step:
(1) take by weighing Herba Taraxaci, Folium Isatidis, Radix Isatidis, Flos Lonicerae by above-mentioned parts by weight, Radix Scutellariae, Cortex Phellodendri, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae are pulverized and mix homogeneously;
(2) decoct extraction 2-4 time, each 2-3 hour;
(3) filter, merge extractive liquid, precipitates with 50%-70% ethanol, crosses to filter precipitate and supernatant;
(4) precipitate in the step (1) is used water dissolution, precipitate with 70%-90% ethanol behind the elimination residue, cross and filter supernatant;
(5) supernatant in combining step (3) and (4) concentrates behind the recovery ethanol, the dry extract that gets;
(6) extract in the step (5) is divided into two equal portions, portion adds organic acid and lubricant and sweeting agent and processes acid particles, and portion adds weak base and lubricant and sweeting agent and processes alkali grain, drying, and again with two kinds of granule mix homogeneously, granulate, packing promptly gets.
The organic acid of making gas-producing disintegrant commonly used has citric acid, tartaric acid etc., and weak base has sodium bicarbonate, sodium carbonate etc.
The characteristic of each crude drug is following in the prescription of the present invention:
Herba Taraxaci: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome is mainly used in treatment skin infection, acute mastitis, lung abscess, conjunctival congestion, pharyngalgia, jaundice due to damp-heat, pyretic stranguria etc.
Folium Isatidis: have heat clearing away, detoxifcation, removing heat from blood and hemostatic effect, be used for pyretic toxicity and send out diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic; Modern study shows that Folium Isatidis can resisting pathogenic microbes, antiinflammatory, effect such as analgesic, raise immunity.
Radix Isatidis has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving; Modern study shows that Radix Isatidis can anti-bacteria and anti-virus, anti-leptospira, detoxifcation, human body immunity improving function, effects such as antitumor.
Flos Lonicerae: have heat-clearing and toxic substances removing, wind-heat dissipating is used for various febrile diseases, and like cards such as fever of the body, dermexanthesis, a speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable; Modern pharmacological research shows that it can resisting pathogenic microbes, and antiinflammatory is analgesic, strengthens human body immune function, central excitation effect, blood fat reducing, effects such as antiendotoxin.
Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering is used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication removes the hectic fever due to YIN-deficiency clearind deficient heat, is used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Herba Pogostemonis: dispelling summer-heat from superficies of the body, removing dampness to restore normal function of the stomach cures mainly the headache of flu, cold and heat, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels, vomiting during pregnancy, nasal sinusitis, tinea manus and pedis.
Herba Pogostemonis: dispelling summer-heat from superficies of the body, removing dampness to restore normal function of the stomach, main summertime flu and cold and heat headache etc.
Gypsum Fibrosum: have expelling pathogenic factors from muscles for clearing heat, the effect that relieving restlessness is quenched the thirst cures mainly the calentura high fever and does not move back, vexed coma, and delirium is gone mad, thirsty and dry pharynx, the lung-heat dyspnea with rapid respiration, the heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat is sent out the speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.The external treatment ulcer sores is burst and is not closed up the burning hot wound of soup.
Radix Glycyrrhizae: ability invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Medicine composition dosage form of the present invention is the effervescency granule, is to utilize organic acid and weak base to meet the water effect to produce carbon dioxide, makes medicinal liquid moment produce great amount of bubbles and is a kind of granule of effervescent state.Because the acid-base neutralization reaction produces carbon dioxide, it is diffusing that granule is collapsed fast, has instant capacity.Be acid after the while carbon dioxide is water-soluble, can stimulate taste bud, can reach the effect of rectifying flavor.The effervescency granule has following advantage: be convenient to preserve and carry; The effervescent tablet disintegrate is quick, easy to use, special taste; Bioavailability is high; Because the significant foam that disintegrate produces has increased direct contact, brings into play its effect better.
Chinese medicine composition of the present invention is that pure Chinese medicine is formed reasonable recipe, strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease.With low cost, easy to use, good effect, toxic and side effects is little.
The specific embodiment
Embodiment 1
Present embodiment a kind of is used to treat the pharmaceutical composition of infectious bursal disease and forms preparation according to following parts by weight of Chinese traditional medicine: 40 parts of Herba Taraxacis, 60 parts of Folium Isatidiss, 160 parts of Radix Isatidis, 40 parts of Flos Loniceraes; 20 parts of Radix Scutellariaes, 20 parts of Cortex Phellodendris, 20 parts of Herba Pogostemoniss, 60 parts in Gypsum Fibrosum, 40 parts in Radix Glycyrrhizae, 25 parts of citric acids, 5 parts of saccharin sodium, 40 parts of sodium bicarbonate, 3 parts of polyethylene glycol 6000s.
The concrete operations step of method for preparing is following:
(1) take by weighing Herba Taraxaci, Folium Isatidis, Radix Isatidis, Flos Lonicerae by above-mentioned parts by weight, Radix Scutellariae, Cortex Phellodendri, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae are pulverized and mix homogeneously;
(2) decoct extraction with distilled water, extract each 2 hours 2 times;
(3) filter, merge extractive liquid, precipitates with 50% ethanol, crosses to filter precipitate and supernatant;
(4) precipitate in the step (1) is used water dissolution, precipitate with 70% ethanol behind the elimination residue, cross and filter supernatant;
(5) supernatant in combining step (3) and (4) concentrates behind the recovery ethanol, the dry extract that gets;
(6) the extract 400g in the step (5) is divided into two equal portions, portion adds 25 parts of citric acids and 5 parts of saccharin sodium mix homogeneously, processes acid particles; Another part adds 40 parts of sodium bicarbonate and 3 parts of polyethylene glycol 6000 mixings are processed alkali grain, drying, and again with two kinds of granule mix homogeneously, granulate, packing promptly gets.
Embodiment 2
Present embodiment a kind of is used to treat the pharmaceutical composition of infectious bursal disease and forms preparation according to following parts by weight of Chinese traditional medicine: 60 parts of Herba Taraxacis, 80 parts of Folium Isatidiss, 200 parts of Radix Isatidis, 60 parts of Flos Loniceraes; 40 parts of Radix Scutellariaes, 40 parts of Cortex Phellodendris, 40 parts of Herba Pogostemoniss, 80 parts in Gypsum Fibrosum, 60 parts in Radix Glycyrrhizae, 30 parts in tartaric acid, 8 parts of sucrose, 50 parts of potassium bicarbonates, 5 parts of Macrogol 4000s.
The concrete operations step is following:
(1) take by weighing Herba Taraxaci, Folium Isatidis, Radix Isatidis, Flos Lonicerae by above-mentioned parts by weight, Radix Scutellariae, Cortex Phellodendri, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae are pulverized and mix homogeneously;
(2) decoct extraction with distilled water, extract each 2 hours 3 times;
(3) filter, merge extractive liquid, precipitates with 60% ethanol, crosses to filter precipitate and supernatant;
(4) precipitate in the step (1) is used water dissolution, precipitate with 80% ethanol behind the elimination residue, cross and filter supernatant;
(5) supernatant in combining step (3) and (4) concentrates behind the recovery ethanol, the dry extract that gets;
(6) the extract 500g in the step (5) is divided into two equal portions, portion adds 30 parts of tartaric acid and 8 parts of sucrose mix homogeneously, processes acid particles; Another part adds 50 parts of potassium bicarbonates and 5 parts of Macrogol 4000 mixings are processed alkali grain, drying, and again with two kinds of granule mix homogeneously, granulate, packing promptly gets.
Embodiment 3
Present embodiment a kind of is used to treat the pharmaceutical composition of infectious bursal disease and forms preparation according to following parts by weight of Chinese traditional medicine: 80 parts of Herba Taraxacis, 100 parts of Folium Isatidiss, 240 parts of Radix Isatidis, 80 parts of Flos Loniceraes; 60 parts of Radix Scutellariaes, 60 parts of Cortex Phellodendris, 60 parts of Herba Pogostemoniss, 120 parts in Gypsum Fibrosum, 80 parts in Radix Glycyrrhizae, 15 parts of citric acids, 5 parts of fumaric acid, 20 parts of malic acids, 15 parts of saccharin sodium, 5 parts of glycyrrhizins, 20 parts of Sorbitols, 20 parts of sodium bicarbonate, 20 parts of sodium carbonate, 20 parts of potassium carbonate, 2 parts of polyethylene glycol 6000s, 2 parts of Macrogol 4000s, 2 parts of magnesium stearate.
The concrete operations step is following:
(1) take by weighing Herba Taraxaci, Folium Isatidis, Radix Isatidis, Flos Lonicerae by above-mentioned parts by weight, Radix Scutellariae, Cortex Phellodendri, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae are pulverized and mix homogeneously;
(2) decoct extraction with distilled water, extract each 3 hours 3 times;
(3) filter, merge extractive liquid, precipitates with 70% ethanol, crosses to filter precipitate and supernatant;
(4) precipitate in the step (1) is used water dissolution, precipitate with 90% ethanol behind the elimination residue, cross and filter supernatant;
(5) supernatant in combining step (3) and (4) concentrates behind the recovery ethanol, the dry extract that gets;
(6) the extract 750g in the step (5) is divided into two equal portions, portion adds 15 parts of citric acids, 5 parts of fumaric acid, 20 parts of malic acids and 15 parts of saccharin sodium, 5 parts of glycyrrhizins, 20 parts of Sorbitol mix homogeneously, processes acid particles; Another part adds 20 parts of sodium bicarbonate, 20 parts of sodium carbonate, 20 parts of potassium carbonate and 2 parts of polyethylene glycol 6000s, 2 parts of Macrogol 4000s, 2 parts of magnesium stearate mixings and processes alkali grain, drying, and again with two kinds of granule mix homogeneously, granulate, packing promptly gets.
Test Example
Surplus chicken farm, Xinxiang, the Henan raising broiler 3000, fall ill during 3 ages in week, sick just have tens of chickens the dysentery symptom to occur, arranges shallow white or light green loose stool, and the perianal feather is polluted by excrement.Along with the development of the state of an illness, drink, loss of appetite, and become thin gradually, fear of cold, the cervical region trunk trembles, instability of gait, body temperature is normal, down in spirits, a sagging catacleisis, feather is matt, fluffy dehydration, eye socket depression, last extreme exhaustion and dead.Death in 5～7 days peaks, and begins later on to descend.
Dehydration, chest muscle obfuscation appear in dead chicken, and chest muscle often has hemorrhage speckle, and mucus increases in the intestinal, kidney enlargement, pale.Infect 4～6 days fabricius bursa in back and enlargement occurs, hemorrhagely sometimes have a flaxen glue peptone appearance transudate, infect back fabricius bursa atrophy in 7～10 days.Spleen possibility silght enlargement, there is the greyish white point necrosis region of dispersivity on the surface.
Comprehensive clinical symptoms and pathology cut open inspection and are diagnosed as chicken bursal disease.
Control drug: capsule must be controlled (production of Shandong veterinary drug company limited, lot number: 20120106).
The normal feeding of infected group but not administration.
Criterion of cure: prothymia, diet is desired normal, and feather is glossy, cuts open the inspection internal organs and does not have the urate calmness, and color and luster is ruddy.
The grouping of table 1 test chicken and curative effect
| Group | The test chicken number of elements | Supply the reagent thing | The medication natural law | Death toll (rate) | Cure number (rate) |
| 1 | 100 | Embodiment 1 | 5 days | 10% | 86% |
| 2 | 100 | Embodiment 2 | 5 days | 12% | 83% |
| 3 | 100 | Embodiment 3 | 5 days | 14% | 80% |
| 4 | 100 | The medicine matched group | 5 days | 20% | 65% |
| 5 | 100 | Infect matched group | - | 78% | - |
Result of the test shows: with Drug therapy infectious bursal disease of the present invention, have good effect.Medicine drinking-water cure rate of the present invention is significantly higher than the medicine matched group.Mortality rate significantly is lower than the infection matched group.Use drug group chicken prothymia of the present invention, diet is desired normal.
Effervescency granule of the present invention can dissolve rapidly in feeding drinking-water, and after sick chicken was used through drinking-water, onset was rapid, reaches the purpose of healing.
Claims (8)
1. pharmaceutical composition that is used to treat infectious bursal disease; It is characterized in that; Comprise following weight portion crude drug: Herba Taraxaci 40-80 part, Folium Isatidis 60-100 part, Radix Isatidis 160-240 part, Flos Lonicerae 40-80 part, Radix Scutellariae 20-60 part, Cortex Phellodendri 20-60 part, Herba Pogostemonis 20-60 part, Gypsum Fibrosum 60-120 part, Radix Glycyrrhizae 40-80 part.
2. a kind of pharmaceutical composition that is used to treat infectious bursal disease according to claim 1 is characterized in that, also comprises organic acid, weak base, lubricant and sweeting agent.
3. a kind of pharmaceutical composition that is used to treat infectious bursal disease according to claim 1 is characterized in that dosage form is the effervescency granule.
4. a kind of pharmaceutical composition that is used to treat infectious bursal disease according to claim 2 is characterized in that, organic acid is a kind of or its combination in any in citric acid, tartaric acid, fumaric acid, acetic acid, malic acid, the adipic acid.
5. a kind of pharmaceutical composition that is used to treat infectious bursal disease according to claim 2 is characterized in that, weak base is selected from a kind of or its combination in any in sodium carbonate, sodium bicarbonate, potassium carbonate, the potassium bicarbonate.
6. a kind of pharmaceutical composition that is used to treat infectious bursal disease according to claim 3 is characterized in that. lubricant is the one or any combination in polyethylene glycol 6000, Macrogol 4000, magnesium stearate, the differential silica gel.
7. a kind of pharmaceutical composition that is used to treat infectious bursal disease according to claim 4 is characterized in that sweeting agent is selected from a kind of or combination in any in sucrose, saccharin sodium, glycyrrhizin, stevioside, the Sorbitol.
8. one kind prepares the pharmaceutical composition that is used to treat infectious bursal disease as claimed in claim 1, it is characterized in that the concrete operations step is:
(1) take by weighing Herba Taraxaci, Folium Isatidis, Radix Isatidis, Flos Lonicerae by weight, Radix Scutellariae, Cortex Phellodendri, Herba Pogostemonis, Gypsum Fibrosum, Radix Glycyrrhizae are pulverized and mix homogeneously;
(2) decoct extraction 2-4 time, each 2-3 hour;
(3) filter, merge extractive liquid, precipitates with 50%-70% ethanol, crosses to filter precipitate and supernatant;
(4) precipitate in the step (1) is used water dissolution, precipitate with 70%-90% ethanol behind the elimination residue, cross and filter supernatant;
(5) supernatant in combining step (3) and (4) concentrates behind the recovery ethanol, the dry extract that gets;
(6) extract in the step (5) is divided into two equal portions, portion adds organic acid, lubricant and sweeting agent and processes acid particles, and portion adds weak base, lubricant and sweeting agent and processes alkali grain, drying, and again with two kinds of granule mix homogeneously, granulate, packing promptly gets.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236946A (en) * | 2016-08-29 | 2016-12-21 | 旌德县德源农业开发有限公司 | A kind of Chinese medicine composition treating a bursa of Fabricius in poultry |
| CN106943491A (en) * | 2017-05-16 | 2017-07-14 | 仁怀市五马镇佛山土鸡养殖场 | A kind of Chinese medicine for treating chicken bursal disease |
| CN107668379A (en) * | 2017-09-30 | 2018-02-09 | 安徽麒麟正大饲料有限公司 | 4% premix for preventing and treating Bursal Disease and preparation method thereof |
| CN111135251A (en) * | 2020-01-09 | 2020-05-12 | 山西中医药大学 | Veterinary drug for preventing and treating chicken bursal disease as well as preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703609A (en) * | 2008-12-03 | 2010-05-12 | 泰安市山农大药业有限公司 | Composition for preventing and treating infectious bursal disease |
| CN101780115A (en) * | 2010-03-23 | 2010-07-21 | 河北农业大学 | Traditional Chinese veterinary medicine micro-capsule preparation and preparation method thereof |
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2012
- 2012-09-19 CN CN2012103479682A patent/CN102836254A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703609A (en) * | 2008-12-03 | 2010-05-12 | 泰安市山农大药业有限公司 | Composition for preventing and treating infectious bursal disease |
| CN101780115A (en) * | 2010-03-23 | 2010-07-21 | 河北农业大学 | Traditional Chinese veterinary medicine micro-capsule preparation and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236946A (en) * | 2016-08-29 | 2016-12-21 | 旌德县德源农业开发有限公司 | A kind of Chinese medicine composition treating a bursa of Fabricius in poultry |
| CN106943491A (en) * | 2017-05-16 | 2017-07-14 | 仁怀市五马镇佛山土鸡养殖场 | A kind of Chinese medicine for treating chicken bursal disease |
| CN107668379A (en) * | 2017-09-30 | 2018-02-09 | 安徽麒麟正大饲料有限公司 | 4% premix for preventing and treating Bursal Disease and preparation method thereof |
| CN111135251A (en) * | 2020-01-09 | 2020-05-12 | 山西中医药大学 | Veterinary drug for preventing and treating chicken bursal disease as well as preparation method and application thereof |
| CN111135251B (en) * | 2020-01-09 | 2021-11-26 | 太原市恩禾动物药业有限公司 | Veterinary drug for preventing and treating chicken bursal disease as well as preparation method and application thereof |
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Application publication date: 20121226 |