CN107233477A - A kind of composition, preparation method and application method for being used to treat porcine respiratory - Google Patents
A kind of composition, preparation method and application method for being used to treat porcine respiratory Download PDFInfo
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- CN107233477A CN107233477A CN201710406195.3A CN201710406195A CN107233477A CN 107233477 A CN107233477 A CN 107233477A CN 201710406195 A CN201710406195 A CN 201710406195A CN 107233477 A CN107233477 A CN 107233477A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention provides a kind of composition, preparation method and application method for being used to treat the composition of porcine respiratory disease, including following component：6~15 parts of spirulina, 10~20 parts of radix bupleuri, 5~13 parts of radix scutellariae, 14~28 parts of the wind-weed, 6~15 parts of balloonflower root, 6~14 parts of the coptis, 2~9 parts of cellulase, 7~14 parts of vegetalitas lactic acid bacteria.Composition provided in an embodiment of the present invention, by the way of Chinese medicine is mixed with cellulase, vegetalitas lactic acid bacteria, with can treat porcine respiratory disease while, improve the immunity of pig body, reduce the incidence of disease of porcine respiratory disease and improve the cure rate and effective percentage of the disease, and do not produce drug resistance and drug-fast advantage.
Description
Technical field
The invention belongs to livestock and poultry cultivation technical field, and in particular to a kind of to be used to treat the composition of porcine respiratory, prepare
Method and application method.
Background technology
It is a kind of general name of multifactor caused breathing problem that porcine respiratory disease syndrome, which is commonly called as blue otopathy (PRRS),
It is caused by the interaction of virus, bacterium, environmental stress and pig body hypoimmunity.The cause of disease of porcine respiratory disease is answered
Miscellaneous and closely related with environment, pathogenic microorganism is generally often in bacterium.Just invaded when respiratory tract is impaired damage location colonization,
Propagation, causes pig to fall ill, when breathing problem occurs, and easily occurs scabies secondary infection or mixed infection, so as to increase the death of pig
Rate, reduction production performance (weightening reduction, food consumption increase, utilization rate reduction), the marketing time for postponing pig, increase are cultivated
Cost etc..
In the prior art, pig is mainly treated using antibiotics (such as aureomycin, Amoxicillin, Florfenicol)
Breathing problem, but use antibiotics to treat the homeostasis for being easily destroyed pig body, and antibiosis is used for a long time
Plain easily to produce drug resistance/resistance to the action of a drug, the effect for the treatment of is not good.In addition, largely using antibiotic, withdrawal time is not enough, easily lead
Cause pork drug residue exceeded, endanger human health.
The content of the invention
The invention provides a kind of composition, preparation method and application method for being used to treat porcine respiratory disease, it is intended to
The homeostasis that antibiotics treatment in the prior art is easily destroyed pig body is solved, and it is easy that antibiotic is used for a long time
Drug resistance/resistance to the action of a drug is produced, the effect for the treatment of is not good.In addition, largely withdrawal time is not enough using antibiotic, pork is easily caused
Drug residue is exceeded, the problem of endangering human health.
What the embodiment of the present invention was realized in：A kind of composition for being used to treat porcine respiratory disease, it is characterised in that
Count by weight, the composition includes：6~15 parts of spirulina, 10~20 parts of radix bupleuri, 5~13 parts of radix scutellariae, the wind-weed 14~28
Part, 6~15 parts of balloonflower root, 6~14 parts of the coptis, 2~9 parts of cellulase, 7~14 parts of vegetalitas lactic acid bacteria.
The embodiment of the present invention additionally provides the above-mentioned preparation method for being used to treat the composition of porcine respiratory disease, the preparation
Method comprises the following steps：
It is placed in after spirulina, radix bupleuri, scutellaria, the wind-weed, balloonflower root, the coptis, cellulase and vegetalitas lactic acid bacteria are mixed
In closed fermenter；
Water vapour is passed through in toward the closed fermenter, the relative humidity in the closed fermenter is reached 82%
More than；
It is under conditions of 32 DEG C~48 DEG C after aerobic fermentation 42~58 hours in temperature, then anaerobic fermentation 70~85 hours；
Composition after anaerobic fermentation is dried.
The embodiment of the present invention additionally provides the above-mentioned application method for being used to treat the composition of porcine respiratory disease, will be described
It is added in pig feed for treating the composition of porcine respiratory disease and uses, wherein, it is described to be used to treat porcine respiratory disease
Composition and pig feed weight ratio be 1:(450~600).
Effect and composition of each raw material are described as follows in above-mentioned composition：
Spirulina：It is a class unicellular lower eukaryote, prokaryotes, the filamentous being made up of unicellular or many cells.Spirulina is sought
The characteristics of forming point is that protein content is high, and fat, content of cellulose are low, and also contains miscellaneous vitamin, it
It is vitamin B12 and content beta-carotene highest food.In addition, absorbability irony content is most in it or all foods
High, while it has also been found that it contains with anti-cancer, the algae protein of effect for cancer, and other a large amount of mineral elements and improves machine
The bioactive substance of body immunity.
Radix bupleuri, be《Chinese Pharmacopoeia》The herbal medicine included, medicinal part is the drying of umbelliferae bupleurum or radix bupleuri scorzoneraefolii
Root, is conventional diaphoretic medicine.It is bitter in taste, be slightly cold, Return liver, gallbladder channel；With antipyretic, calm, analgesia, anti-inflammatory, antipathogen, reconciliation
It is soothing the liver in table, the effects such as rising Yang；It is mainly used in cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses take off
Anus etc..
Radix scutellariae：Labiate, is used as medicine with root；It is bitter in taste, tremble with fear, return lung, courage, spleen, stomach, large intestine, small intestinl channel；With anti-
The effects such as bacterium, antiviral, anti-inflammatory, suppression immune response, antipyretic, liver protection, cholagogic, calmness, Green Tea Extract are damaged, and do not produce
The resistance to the action of a drug；Cure mainly heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot feeling of fullness,
Rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability etc..
The wind-weed, liliaceous plant, rhizome is used as medicine；It is bitter in taste, sweet, tremble with fear；Return lung, stomach, kidney channel；With clearing heat-fire, promote the production of body fluid
Moisturize, antibacterial the effects such as.It is mainly used in treating fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, intestinal dryness
Constipation etc..
Balloonflower root, it is bitter in taste, pungent, it is mild-natured；Return lung is passed through；With eliminating the phlegm, antibechic, hypoglycemic, anti-inflammatory, suppress gastric secretion and anti-
The effects such as ulcer, facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis；It is mainly used in treating coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, sound is mute, and lung carbuncle is told
Purulence, sore purulence into not burst etc..
The coptis：It is bitter in taste, tremble with fear；The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel；With heat-clearing and damp-drying drug, purging intense heat and detonicating, antimicrobial
And disease-resistant protozoon, have special efficacy, anticancer, anti-radiation and the suppression to the metabolism of cell, cholagogic, reduction serum courage to processing anaerobic bacteria
Sterol, it is hypoglycemic the effects such as.It is mainly used in damp and hot feeling of fullness, vomits acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity is vexed
It is insomnia, blood-head tells nosebleed, hot eyes, toothache is quenched one's thirst, carbuncle swells furunculosis；Eczema is controlled outside, wet sore, duct is suppurated.
Cellulase：It is the general name of the glucogenic one group of enzyme of degraded cellulose, it is not monomeric enzyme, but plays collaboration
The multicomponent enzyme system of effect, is a kind of complex enzyme, acts on cellulose and the product being derived from cellulose.
Vegetalitas lactic acid bacteria:It is that separation screening comes out from traditional vegetalitas fermented food such as pickles, salted vegetables, thick broad-bean sauce
A class lactic acid bacteria, enough improve intestinal environment, improve immunity.
Composition provided in an embodiment of the present invention, by the way of Chinese medicine is mixed with cellulase, vegetalitas lactic acid bacteria, tool
Have and can improve the immunity of pig body while porcine respiratory disease is treated, reduce the incidence of disease of porcine respiratory disease simultaneously
The cure rate and effective percentage of the disease are improved, and does not produce drug resistance and drug-fast advantage.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Composition provided in an embodiment of the present invention, by the way of Chinese medicine is mixed with cellulase, vegetalitas lactic acid bacteria, tool
Have and can improve the immunity of pig body while porcine respiratory disease is treated, reduce the incidence of disease of porcine respiratory disease simultaneously
The cure rate and effective percentage of the disease are improved, and does not produce drug resistance and drug-fast advantage.In addition, the reasonable of plurality of Chinese is matched somebody with somebody
Than the smell of spirulina can be covered so that composition is the taste for being adapted to pig, it is possible to increase the appetite of pig.
Composition provided in an embodiment of the present invention, by weight, said composition includes：6~15 parts of spirulina, radix bupleuri 10~
20 parts, 5~13 parts of radix scutellariae, 14~28 parts of the wind-weed, 6~15 parts of balloonflower root, 6~14 parts of the coptis, 2~9 parts of cellulase, vegetalitas breast
Sour 7~14 parts of bacterium.
It is preferred that, by weight, said composition includes：6~12 parts of spirulina, 13~20 parts of radix bupleuri, 7~13 parts of radix scutellariae,
18~28 parts of the wind-weed, 10~15 parts of balloonflower root, 6~11 parts of the coptis, 2~7 parts of cellulase, 7~11 parts of vegetalitas lactic acid bacteria.
It is preferred that, by weight, said composition includes：8~12 parts of spirulina, 16~20 parts of radix bupleuri, 9~13 parts of radix scutellariae,
22~28 parts of the wind-weed, 10~12 parts of balloonflower root, 9~11 parts of the coptis, 4~7 parts of cellulase, 9~11 parts of vegetalitas lactic acid bacteria.
It is preferred that, spirulina can for the former powder of spirulina natural, deodorant spirulina, the one of which of spirulina extract or
Person is a variety of.
It is preferred that, vegetalitas lactic acid bacteria can be Lactobacillus plantarum.
The preparation method of the above-mentioned composition for treating porcine respiratory disease is as follows：
(1) spirulina, radix bupleuri, scutellaria, the wind-weed, balloonflower root, the coptis, cellulase and vegetalitas lactic acid bacteria are mixed rearmounted
In closed fermenter；
(2) toward water vapour is passed through in the closed fermenter, reach the relative humidity in the closed fermenter
More than 82%；
(3) after aerobic fermentation under conditions of temperature is 32 DEG C~48 DEG C 42~58 hours, then anaerobic fermentation 70~85 is small
When；
(4) composition after anaerobic fermentation is dried.
Before above-mentioned step (1), in order to fully fermentation, may also include by by spirulina, radix bupleuri, scutellaria, the wind-weed,
The step of balloonflower root, the coptis, cellulase and vegetalitas lactic acid bacteria are crushed respectively.
, can be by the way that closed fermenter be placed in 32 DEG C~48 DEG C of thermostatic chamber to control in above-mentioned steps (3)
The temperature of closed fermenter is controlled, it is of course also possible to meet temperature requirement by other temperature controlled modes.32 DEG C~
Composition is transferred to other and is adapted to carry out in the environment of anaerobic fermentation by aerobic fermentation after 42~58 hours under conditions of 48 DEG C
Anaerobic fermentation, but in order to avoid metastatic composition, can be by continuing to detest under conditions of the starvation in closed fermenter
Aerobe fermentation.Wherein, during aerobic fermentation, can by gas valve toward be passed through in fermentation tank by sterilizing oxygen or
Air is simultaneously stirred, so that oxygen or air can be thoroughly mixed among composition, to ensure the abundant complete of aerobic fermentation
Entirely.It is of course also possible to regulate and control the oxygen/air content in fermentation tank by other means, to ensure in the aerobic fermentation stage
The oxygen/air of abundance can be provided.
Above-mentioned step (4), can carry out drying operation by hot-water heating dryer.
It is preferred that, in order that pig preferably digests composition and is easy to the mixing of composition and feed, step (4) it
After can also comprise the following steps：It is 150~300 mesh that composition after drying, which is crushed,.
Above-mentioned preparation method, prepares composition, technique is simple and can keep various Chinese herbal medicines by the way of fermentation
Medical value so that composition treatment effect is good.
The above-mentioned application method for being used to treat the composition of porcine respiratory disease is to be used to treat porcine respiratory disease by this
Composition be added in pig feed and use, wherein, the weight of the composition for being used to treat porcine respiratory disease and pig feed
Than for 1:(450~600).
Technical scheme and technique effect are described further below by way of specific embodiment.
In embodiment 1~5, preparation method is：First by spirulina, radix bupleuri, scutellaria, the wind-weed, balloonflower root, the coptis, fiber
Plain enzyme, the mixing of vegetalitas lactic acid bacteria are placed in closed fermenter, are then passed through water vapour to the closed fermenter, are made
Relative humidity in closed fermenter is reached after requirement, aerobic fermentation, then carries out anaerobic fermentation；Finally by after anaerobic fermentation
Composition is dried.Wherein, the component for being used to treat the composition of porcine hyperthermia in embodiment 1~5 is as shown in table 1, prepares
Condition is as shown in table 2：
Table 1
| Component | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Spirulina (gram) | 60 | 100 | 150 | 120 | 80 |
| Radix bupleuri (gram) | 130 | 185 | 200 | 160 | 100 |
| Scutellaria (gram) | 90 | 50 | 110 | 70 | 130 |
| The wind-weed (gram) | 180 | 220 | 140 | 250 | 280 |
| Balloonflower root (gram) | 60 | 100 | 90 | 150 | 120 |
| The coptis (gram) | 140 | 60 | 110 | 90 | 120 |
| Cellulase (gram) | 90 | 70 | 40 | 20 | 50 |
| Vegetalitas lactic acid bacteria (gram) | 110 | 90 | 140 | 70 | 100 |
Table 2
| Preparation condition | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Relative humidity (%) | 82 | 85 | 90 | 85 | 90 |
| Aerobic fermentation temperature (DEG C) | 40 | 45 | 32 | 38 | 48 |
| The aerobic fermentation time (hour) | 45 | 55 | 42 | 58 | 50 |
| The anaerobic fermentation time (hour) | 72 | 75 | 80 | 85 | 70 |
| Grinding particle size (mesh) | 180 | 250 | 200 | 150 | 300 |
The plant breast bar that lactic acid bacteria used in above-described embodiment 1~3 provides for Shaanxi Sen Fu natural products Co., Ltd
Bacterium；The Lactobacillus plantarum that lactic acid bacteria used in embodiment 4~5 provides for Shandong sunflower bio tech ltd.It is above-mentioned
Cellulase in embodiment 1~5 produces for Tai'an letter bioengineering Co., Ltd that gets profit.Used in above-described embodiment 1~3
The spirulina powder that is provided for Etuoke Banner/Kang Sheng Zao Ye Co., Ltds of spirulina, spiral used in embodiment 4~5
The spirulina extract that algae provides for the standing grain bio tech ltd of Lanzhou hundred.
In order to further illustrate that the composition provided in an embodiment of the present invention for being used to treat porcine respiratory disease is breathed to pig
The therapeutic effect of tract disease, and clinical observation on the therapeutic effect experiment has been carried out to the composition of the present invention, enter one below by way of test example
Step illustrates the beneficial effect of the present composition：
Experiment 1：The toxicological test of the Chinese medicine composition of the present invention：
ICR mouse 60 are selected, male and female half and half, body weight is randomly divided into 6 groups, every group 10, is respectively in (25 ± 5) gram
Blank control group and test group 1~5, blank control group feeding basal feed, feeding with the addition of embodiment 1 to test group 1~5 respectively
The feed of~5 composition, the i.e. feeding of test group 1 with the addition of the feed of the composition of embodiment 1, and the feeding of test group 2 with the addition of
The feed of the composition of embodiment 2, the feeding of test group 3 with the addition of the feed of the composition of embodiment 3, the addition of the feeding of test group 4
The feed of the composition of embodiment 4, the feeding of test group 5 with the addition of the feed of the composition of embodiment 5.Group in each test group
It is 1 to close by the weight ratio of composition and feed：50 are added in feed.Wherein, the forage volume that each group is fed is identical, feeds daily
Food 2 times, after 6 hours.Continuously feed and observe after 20 days, as a result all mouse are strong deposits, its daily routines, hair, body weight,
Food ration, excreta are showed no exception.4 are randomly selected from each group mouse, male and female half and half check that blood and blood biochemical refer to
Mark, takes dissection after blood to carry out pathological examination.
Checked more than, the Index for examination of each group mouse is in normal range (NR), and test group 1~5 and blank control group
Phase less notable difference.Toxicological test proves that the medicine no toxic effects and adverse reaction, clinical practice are safe and reliable.
Experiment 2：
The pig 280 at 3 monthly ages in certain pig farm is chosen, 280 pigs are diagnosed as affected pig breathing problem, by this
Batch pig stochastic averagina is distributed into 7 groups, every group 40, and every group of pig is isolated in into the local stable breeding of condition identical.Group 1 is blank pair
According to group, only fed with basic pig feed；Group 2~groups 7 are test group, and group 2~7 is respectively to the addition of the combination in embodiment 1~5
The pig feed of thing and the pig feed nursing that with the addition of antibiotic, that is, organize 2 pig feeds with the addition of the composition in embodiment 1 and feed
Support, group 3 is fed with the pig feeds that with the addition of the composition in embodiment 2, group 4 is to the addition of the pig of the composition in embodiment 3
Forage feed, group 5 is fed with the pig feed that with the addition of the composition in embodiment 4, organizes 6 to the addition of the combination in embodiment 5
The pig feed of thing is fed, and group 7 is fed with the pig feed that with the addition of antibiotic.Wherein, the addition of the composition in group 2~groups 4
It is：The weight ratio of composition and pig feed is 1：450；The addition of composition in group 5~groups 6 is：Composition and pig
The weight ratio of feed is 1：600；The usage and dosage of antibiotic addition to specifications in group 7.Every time toward in each group swinery
Same amount of pig feed is delivered, is delivered three times daily, every time after 4 hours, pig free choice feeding regularly checks the situation of pig daily
And make a record.After continuous nursing 5 days, experiment is completed, and data statistics is carried out to the result recorded, concrete outcome is shown in Table 3.
Wherein, in this process of the test, the criterion of curative effect is：After healing finger to finger test terminates, the appetite of pig is recovered just
Often, clinical symptoms recover normal completely；After effective finger to finger test terminates, the appetite and clinical disease of pig have taken a turn for the better and recovered just
Often；Occur death during invalid finger to finger test or appetite, clinical symptoms do not take a turn for the better.
Table 3
| Sick pig number (head) | Invalid (head) | Effectively (head) | Cure (head) | |
| Group 1 | 40 | 40 | 0 | 0 |
| Group 2 | 40 | 5 | 35 | 30 |
| Group 3 | 40 | 2 | 38 | 32 |
| Group 4 | 40 | 6 | 34 | 29 |
| Group 5 | 40 | 0 | 40 | 36 |
| Group 6 | 40 | 3 | 37 | 30 |
| Group 7 | 40 | 15 | 25 | 15 |
It was found from the result of experiment 2, the composition in the embodiment of the present invention can treat porcine respiratory disease, and curative effect is excellent
In using antibiotic therapy.And during experiment, the average daily consumption of feed of the swinery in discovery group 2~6 is 61kg, group
The average daily consumption of feed of swinery in 1 is 40kg, and the average daily consumption for organizing the swinery feed in 7 is 52kg.As can be seen here, originally
Composition in inventive embodiments compares the taste for being more suitable for pig with antibiotic, can improve the appetite of pig.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (7)
1. a kind of composition for being used to treat porcine respiratory disease, it is characterised in that count by weight, the composition bag
Include：6~15 parts of spirulina, 10~20 parts of radix bupleuri, 5~13 parts of radix scutellariae, 14~28 parts of the wind-weed, 6~15 parts of balloonflower root, the coptis 6~14
Part, 2~9 parts of cellulase, 7~14 parts of vegetalitas lactic acid bacteria.
2. the composition as claimed in claim 1 for being used to treat porcine respiratory disease, it is characterised in that count by weight,
The composition includes：6~12 parts of spirulina, 13~20 parts of radix bupleuri, 7~13 parts of radix scutellariae, 18~28 parts of the wind-weed, balloonflower root 10~15
Part, 6~11 parts of the coptis, 2~7 parts of cellulase, 7~11 parts of vegetalitas lactic acid bacteria.
3. the composition as claimed in claim 1 for being used to treat porcine respiratory disease, it is characterised in that count by weight,
The composition includes：8~12 parts of spirulina, 16~20 parts of radix bupleuri, 9~13 parts of radix scutellariae, 22~28 parts of the wind-weed, balloonflower root 10~12
Part, 9~11 parts of the coptis, 4~7 parts of cellulase, 9~11 parts of vegetalitas lactic acid bacteria.
4. a kind of method for being used to treat the composition of porcine respiratory disease prepared as described in any one of claims 1 to 3, its
It is characterised by, the preparation method comprises the following steps：
It is placed in after spirulina, radix bupleuri, scutellaria, the wind-weed, balloonflower root, the coptis, cellulase and vegetalitas lactic acid bacteria are mixed closed
In formula fermentation tank；
Be passed through water vapour in toward the closed fermenter, make the relative humidity in the closed fermenter reach 82% with
On；
It is under conditions of 32 DEG C~48 DEG C after aerobic fermentation 42~58 hours in temperature, then anaerobic fermentation 70~85 hours；
Composition after the anaerobic fermentation is dried.
5. preparation method as claimed in claim 4, it is characterised in that it is described by spirulina, radix bupleuri, scutellaria, the wind-weed, balloonflower root,
Also include before being placed in the step in closed fermenter after the coptis, cellulase and the mixing of vegetalitas lactic acid bacteria：
Spirulina, radix bupleuri, scutellaria, the wind-weed, balloonflower root, the coptis, cellulase and vegetalitas lactic acid bacteria are crushed respectively.
6. preparation method as claimed in claim 4, it is characterised in that what the composition by after anaerobic fermentation was dried
Also include after step：
It is 150~300 mesh that composition after the drying, which is crushed,.
7. a kind of being used for as described in any one of claims 1 to 3 treats the application method of the composition of porcine respiratory disease, its
It is characterised by, the composition for treating porcine respiratory disease is added in pig feed and used, wherein, it is described to be used to control
The weight ratio of the composition and pig feed for the treatment of porcine respiratory disease is 1:(450~600).
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Cited By (1)
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