CN107260919A - A kind of composition, preparation method and its application method for being used to prevent and treat swine enteritis - Google Patents
A kind of composition, preparation method and its application method for being used to prevent and treat swine enteritis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention provides a kind of composition, preparation method and application method for being used to prevent and treat swine enteritis, count by ratio of weight and the number of copies, the composition includes：7~20 parts of spirulina, 8~18 parts of dried orange peel, 4~12 parts of golden cypress, 3~15 parts of rheum officinale, 3~12 parts of betel nut, 8~13 parts of the Radix Astragali, 16~24 parts of vegetalitas lactic acid bacteria, 2~15 parts of protease.Composition provided in an embodiment of the present invention, by the way of Chinese herbal medicine and strain mixing, with can safely and effectively improve the autoimmunity of pig, reduces the incidence of disease of swine enteritis and promotes rehabilitation speed, and do not produce drug resistance and drug-fast advantage.
Description
Technical field
The invention belongs to cultural technique field, and in particular to it is a kind of be used to preventing and treating the compositions of swine enteritis, preparation method and
Its application method.
Background technology
Swine enteritis are a kind of acute infectious intestinal diseases of pig.Clinical symptoms is diarrhoea, vomits and be dehydrated.It can betide various
Piglet case fatality rate within the pig at age, 10 ages in days is very high, and pig case fatality rate more than 5 week old is very low, larger pig or Adult Pig
Almost without death.Its pathogen is the transmissible gastro-enteritis virus of coronaviridae, is primarily present in jejunum, duodenum
And the mucous membrane of ileum, under nasal cavity, tracheae, the mucous membrane of lung and tonsillotome, jaw and lymphonodi mesenterici etc. can also find virus.
It is viral to daylight and thermo-responsive, there is resistance to trypsase and pig's bile.
In the prior art, in order to treat swine enteritis, drug therapy such as antibiotherapy is generally used, however, anti-
The microflora that raw extract for treating can be destroyed inside pig, and antibiotic is used for a long time easily produces drug resistance, prevention effect is not yet
Most people's will.In addition, largely using antibiotic, withdrawal time is not enough, it is exceeded to be easily caused pork drug residue, and the harm mankind are strong
Health.
The content of the invention
The invention provides a kind of composition, preparation method and its application method for being used to prevent and treat swine enteritis, it is intended to solves
The microflora that antibiotic therapy can be destroyed inside pig in the prior art, and long-term use antibiotic easily produces drug resistance,
Prevention effect is also unsatisfactory.In addition, largely withdrawal time is not enough using antibiotic, it is easily caused pork drug residue and surpasses
The problem of mark, harm human health.
What the embodiment of the present invention was realized in：A kind of composition for being used to prevent and treat swine enteritis, is counted, institute by ratio of weight and the number of copies
Stating composition includes：7~20 parts of spirulina, 8~18 parts of dried orange peel, 4~12 parts of golden cypress, 3~15 parts of rheum officinale, 3~12 parts of betel nut is yellow
8~13 parts of stilbene, 16~24 parts of vegetalitas lactic acid bacteria, 2~15 parts of protease.
The embodiment of the present invention, which is additionally provided, prepares the above-mentioned method for preventing and treating swine enteritis composition, the preparation method
Comprise the following steps：
By spirulina, dried orange peel, golden cypress, rheum officinale, betel nut, the Radix Astragali, vegetalitas lactic acid bacteria and protease are added to closed
In fermentation tank；
Water vapour is passed through to the closed fermenter, the closed fermenter relative humidity is reached more than 85%；
After fermentation under conditions of temperature is 35 DEG C~45 DEG C 40~60 hours, anaerobic fermentation 60~100 hours；
Dry the composition after anaerobic fermentation.
The embodiment of the present invention additionally provides the above-mentioned application method for being used to prevent and treat the composition of swine enteritis, the user
The composition for preventing and treating swine enteritis is added in pig feed by method to be used, wherein, the group for being used to prevent and treat swine enteritis
The composition of compound and the weight ratio of pig feed are 1:400~550.
Effect and composition of each raw material are described as follows in above-mentioned composition：
Spirulina：It is a class unicellular lower eukaryote, prokaryotes, the filamentous being made up of unicellular or many cells.Spirulina is sought
The characteristics of forming point is that protein content is high, and fat, content of cellulose are low, and also contains miscellaneous vitamin, it
It is that absorbability irony content is most in addition, in it or all foods by vitamin B12 and content beta-carotene highest food
High, while it has also been found that it contains with anti-cancer, the algae protein of effect for cancer, and other a large amount of mineral elements and improves machine
The bioactive substance of body immunity.
Dried orange peel：Rutaceae orange and its dry mature skin of variety.It is bitter, pungent, it is warm-natured.Dried orange peel is contained to volatilize
Intestines and stomach are had gentle stimulation by oil, can promote the secretion of digestive juice, exclude pneumatosis in intestinal tube, it is shown that fragrant stomach invigorating
With the effectiveness of gas under wind dispelling, dried orange peel decoction is used in combination with vitamin C, vitamin K, can strengthen antiinflammation.
Golden cypress：Nature and flavor：Bitter, it is cold in nature.For damp-heat dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted,
Hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore.Golden cypress nourishing Yin and falling fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Rheum officinale：Gas is special, bitter and micro-puckery.Returns spleen, stomach, large intestine, liver, pericardium channel Chinese herb rhubarb, which have, attacks stagnant, clear wet
The effects such as heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances.
The Radix Astragali：It is sweet, it is warm-natured, enter spleen, lung channel, there is help spleen soil, rise and lift yang-energy, strengthening exterior and reducing sweat, the effect such as torr sore myogenic,
It is mainly used in spleen-lung Qi deficiency caused weak anorexia and loose stool, palpitation, the visceral organ ptosis of the sinking of qi of middle-jiao, Qi dysfunction in blood control collapses
Leakage, has blood in stool, rush down prolapse of the anus for a long time；The spontaneous sweating of exterior deficiency, the card such as insufficiency of vital energy and blood.The Radix Astragali strengthens contractile ability, can change
The blood circulation of kind whole body, can coronary artery dilator, Renal vascular and adder-wort peripheral vessel, make skin blood overactive circulation；It can carry
The nonspecific immunity power of high body, there is liver protection and reduction blood glucose, to staphylococcus, blood dissolubility streptococcus, the double balls of pneumonia
Bacterium, shigella dysenteriae etc. have inhibitory action.The Radix Astragali can significantly affect splenic lymphocytes Information Conduction, realize immunoregulation effect.
Betel nut：Important Chinese medicine, enters spleen, stomach, and large intestine, lung four are passed through, and betel nut is with " desinsection, breaks product, and sending down abnormally ascending row is stagnant, OK
Effect of water dampness ".
Plant lactobacillus：It is that separation screening comes out from traditional vegetalitas fermented food such as pickles, salted vegetables, thick broad-bean sauce
One class lactic acid bacteria, including Lactobacillus plantarum, Lactobacillus casei, Lactobacillus brevis etc..Intestinal environment can be improved, immunity is improved.
Protease：Protease is the general name of the class of enzymes of aminosal peptide chain.Protease be widely present in pluck,
In plant stem-leaf, fruit and microorganism.Microbial protease, mainly by mould, bacterium, is secondly produced by yeast, actinomyces.Egg
White enzyme is a kind of most important industrial enzyme preparation, and energy catalytic proteins and many hydrolase polypeptides are widely present in pluck, axis
In leaf, fruit and microorganism.The all substantial amounts of use protease in the modification of cheesemaking, tenderization and vegetable protein.
Composition provided in an embodiment of the present invention, by the way of Chinese herbal medicine and strain mixing, with can have safely
Effect ground improves the autoimmunity of pig, reduces the incidence of disease of swine enteritis and promotes rehabilitation speed, and does not produce drug resistance and anti-
The advantage of the property of medicine.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Composition provided by the present invention for preventing and treating swine enteritis, by the way of Chinese herbal medicine and strain mixing, to carry
The immunity of high pig, can reduce the illness rate that swine enteritis occur for pig, while can have promotion health to occurring the pig of swine enteritis
The effect of complex-velocity rate.Meanwhile, a variety of Chinese herbal medicine rational proportions are adapted to the taste of pig, therefore can also improve the appetite of pig.This hair
The composition that bright embodiment is provided, is counted by ratio of weight and the number of copies, including：12~17 parts of spirulina, 12~15 parts of dried orange peel, golden cypress 8~
12 parts, 6~10 parts of rheum officinale, 8~12 parts of betel nut, 10~13 parts of the Radix Astragali, 18~21 parts of vegetalitas lactic acid bacteria, proteinase 8~15 part.
Preferably, count by ratio of weight and the number of copies, above-mentioned composition includes：12~15 parts of spirulina, 15 parts of dried orange peel, golden cypress 8~
10 parts, 10 parts of rheum officinale, 8~10 parts of betel nut, 9 parts of the Radix Astragali, 21 parts of vegetalitas lactic acid bacteria, 12 parts of protease.
Preferably, count by ratio of weight and the number of copies, above-mentioned composition includes：12~15 parts of spirulina, 15 parts of dried orange peel, golden cypress 8~
10 parts, 10 parts of rheum officinale, 8~10 parts of betel nut, 9 parts of the Radix Astragali, 21 parts of vegetalitas lactic acid bacteria, 12 parts of protease.
Preferably, plant lactobacillus is lactobacillus plantarum.Spirulina can be the former powder of spirulina natural, deodorant spiral
Algae, the one of which of spirulina extract or a variety of.
The preparation method of the above-mentioned composition for preventing and treating swine enteritis is as follows：
The first step：By spirulina, dried orange peel, golden cypress, rheum officinale, betel nut, the Radix Astragali, vegetalitas lactic acid bacteria and protease are added to
In closed fermenter；
Second step：Water vapour is passed through to the closed fermenter, the closed fermenter relative humidity is reached
More than 85%；
3rd step：After fermentation under conditions of temperature is 35 DEG C~45 DEG C 40~60 hours, anaerobic fermentation 60~100 is small
When；
4th step：Dry the composition after anaerobic fermentation.
Before the above-mentioned first step, in order to fully fermentation, it can also include spirulina, dried orange peel, golden cypress, rheum officinale,
Betel nut, the Radix Astragali, the step of vegetalitas lactic acid bacteria and protease are crushed respectively.
In above-mentioned second step, it can be stirred when being passed through water vapour to closed fermenter, so that composition thing
The humidity of matter is uniform.
Can be 35~45 degree of interior to control by the way that closed fermenter is positioned over into temperature in the 3rd above-mentioned step
The temperature of closed fermenter, it is of course also possible to meet temperature requirement by other temperature controlled modes.At 35 DEG C~45 DEG C
Under conditions of fermentation 40~60 hours after, composition can be transferred to other be adapted to anaerobic fermentations environment in carry out anaerobism hair
Ferment, but in order to avoid metastatic composition, can be by continuing anaerobic fermentation under conditions of the starvation in closed fermenter.
It should be noted that in the present invention, unless otherwise instructed or limit, fermentation refers to aerobic fermentation.
In the 4th above-mentioned step, it can be dried by hot-water heating dryer.
Preferably, in order that pig more preferably digests composition and facilitates composition to be mixed with feed, may be used also after the 4th step
To comprise the following steps：Dried composition powder is broken to 100~250 mesh.
Above-mentioned preparation method, prepares composition, technique is simple and can keep various Chinese herbal medicines by the way of fermentation
Medical value so that composition for preventing and controlling effect is good.
The application method of the above-mentioned composition for controlling swine enteritis is that the composition of the preventing and treating sea cucumberization skin is added into pig to raise
Used in material, wherein, the composition of pig sea cucumberization skin and the weight ratio of pig feed are 1:400~550
Technical scheme and technique effect are described further below by way of specific embodiment.
Embodiment 1
By 70 grams of spirulina, 90 grams of dried orange peel, 40 grams of golden cypress, 30 grams of rheum officinale, 30 grams of betel nut, 80 grams of the Radix Astragali, vegetalitas lactic acid
160 grams of bacterium, 20 grams of protease is crushed respectively, is added in closed fermenter.And water vapour is passed through to closed fermenter, make
The relative humidity of closed fermenter is 88%.Fermented 40 hours in the environment of closed fermenter is positioned over into 35 DEG C, then
Composition is transferred to after anaerobic fermentation tank ferments 80 hours and taken out, said composition is dried, and be crushed to 200 mesh.
Embodiment 2
By 200 grams of spirulina, 180 grams of dried orange peel, 100 grams of golden cypress, 150 grams of rheum officinale, 120 grams of betel nut, 120 grams of the Radix Astragali, plant
210 grams of lactic acid bacteria of property, 120 grams of protease is crushed, is added in closed fermenter respectively.And it is passed through water to closed fermenter
Steam, the relative humidity for making closed fermenter is 90%.Fermentation 60 is small in the environment of closed fermenter is positioned over into 42 DEG C
When, then composition is transferred to after anaerobic fermentation tank ferments 60 hours and taken out, said composition is dried, and be crushed to 200 mesh.
Embodiment 3
By 150 grams of spirulina, 100 grams of dried orange peel, 120 grams of golden cypress, 100 grams of rheum officinale, 80 grams of betel nut, 100 grams of the Radix Astragali, vegetalitas
240 grams of lactic acid bacteria, 150 grams of protease is crushed respectively, is added in closed fermenter.And it is passed through water steaming to closed fermenter
Vapour, the relative humidity for making closed fermenter is 95%.Temperature with temperature controlled closed fermenter is set to 40 DEG C,
Composition, is then transferred to after anaerobic fermentation tank ferments 100 hours and takes out, dry said composition, and crush by fermentation 50 hours
To 200 mesh.
Embodiment 4
By 120 grams of spirulina, 120 grams of dried orange peel, 90 grams of golden cypress, 80 grams of rheum officinale, 60 grams of betel nut, 130 grams of the Radix Astragali, vegetalitas breast
Sour 180 grams of bacterium, 0 gram of proteinase 8 is crushed, is added in closed fermenter respectively.And water vapour is passed through to closed fermenter,
The relative humidity for making closed fermenter is 95%.Temperature with temperature controlled closed fermenter is set to 45 DEG C, hair
Composition, is then transferred to after anaerobic fermentation tank ferments 60 hours and takes out, dry said composition, and be crushed to by ferment 48 hours
100 mesh.
Embodiment 5
By 170 grams of spirulina, 150 grams of dried orange peel, 80 grams of golden cypress, 60 grams of rheum officinale, 100 grams of betel nut, 100 grams of the Radix Astragali, vegetalitas
210 grams of lactic acid bacteria, 0 gram of proteinase 9 is crushed respectively, is added in closed fermenter.And it is passed through water steaming to closed fermenter
Vapour, the relative humidity for making closed fermenter is 95%.Temperature with temperature controlled closed fermenter is set to 40 DEG C,
Composition, is then transferred to after anaerobic fermentation tank ferments 80 hours and takes out, dry said composition, and be crushed to by fermentation 48 hours
250 mesh.
The pancreas that the protease that the above embodiments 1 and embodiment 2 are used produces for Nanjing Tian Jia bio tech ltd
Protease, the pepsin that the protease that embodiment 3~5 is used produces for Shaanxi Sen Fu natural products Co., Ltd.Above-mentioned reality
The vegetalitas lactic acid bacteria for applying example 1~3 is Lactobacillus plantarum, is Cangzhou Zhongxin Biological Technology Co., Ltd.'s production, above-mentioned implementation
The vegetalitas lactic acid bacteria of example 4~5 is the prosperous hair biotechnology research institute production in Cangzhou.
Experiment 1：The toxicity test of the Chinese medicine composition of the present invention
ICR mouse 30 are taken, body weight is at 30~40 grams, random packet, every group 10, male and female half and half, using in embodiment 1
Composition feed above-mentioned mouse, amount of composition be respectively 0.2g/ only, 0.4g/ only, 0.8g/ only and 1.2g/ only.It is continuous after administration
Observation 20 days, as a result all mouse are strong deposits, and its activity, diet, hair, excreta are no abnormal, have no toxic reaction.Dialogue
Mouse oral cavity and damaged skin carry out irritation test, there are no irritative response and other adverse reactions.Toxicity test is proved, is somebody's turn to do
Medicine no toxic effects and adverse reaction, clinical practice are safe and reliable.
Experiment 2：
4~5 age in days piglet 250 is taken, stochastic averagina is divided into five groups, and group 1 is healthy control group, and piglet is only used without illness
Basal feed is fed.Group 2 is fed using with healthy control group identical basal feed, while feeding transmissible gastroenteritis of swine strain
It is not administered afterwards.Organize 3~group 5 uses to feed with healthy control group identical basal feed, attack after malicious transmissible gastroenteritis of swine strain
The composition added respectively in feed in embodiment 1~3 in 12 hours, that is, organize 3 compositions added in embodiment 1, and group 4 adds
Enter the composition in embodiment 2, the composition that group 5 is added in embodiment 3.The weight ratio of composition and feed is 1：500；Respectively
Group pig free choice feeding, drinking-water, Routine Management；Raise identical number of days, daily 12:00 observation sick pig symptom, dead pig weighs,
Anatomic observation pathological change, and record is performed, not dead pig is weighed after two weeks, dissected, and lesion situation is recorded, test
After the completion of, to the experiment death rate, cure rate, efficient progress data statistics, concrete outcome is shown in Table 1.
In this experimentation, all symptoms for occurring transmissible gastroenteritis of swine during testing are simultaneously dead, and ptomatopsia is ill
The person of becoming apparent, is judged to infection dead.After medication, dead pig is not effective；After medication, the state of mind, appetite etc. recover normal
Pig belong to recovery from illness.
Table 1
It can be drawn by testing 2 results：The composition of the embodiment of the present invention can treat swine enteritis.
Experiment 3
210 15 age in days piglets in a pig farm are chosen, three groups are randomly divided into, group 1 is fed using normal diet, group 2 is adopted
Fed with the feed for the composition for adding embodiment 4, group 3 is carried out using the feed for the composition for adding embodiment 5
Feed, the weight ratio of composition and feed is 1：550；Pig free choice feeding.The pig of group 1~groups 3 is attacked after feeding 20 days
Malicious transmissible gastroenteritis of swine strain, the illness rate of the swine enteritis of discovery group 1 is 90%, and illness weight.3 swine enteritis of group 2 and group
Illness rate is about 30% and 40%, symptom 1 mild symptoms of relative group.
It can be drawn by experiment 3：The composition of the embodiment of the present invention can prevent swine enteritis.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (8)
1. a kind of composition for being used to prevent and treat swine enteritis, it is characterised in that count by ratio of weight and the number of copies, the composition includes：Spiral shell
Revolve 7~20 parts of algae, 8~18 parts of dried orange peel, 4~12 parts of golden cypress, 3~15 parts of rheum officinale, 3~12 parts of betel nut, 8~13 parts of the Radix Astragali, plant
Property 16~24 parts of lactic acid bacteria, 2~15 parts of protease.
2. the composition as claimed in claim 1 for being used to prevent and treat swine enteritis, it is characterised in that count by ratio of weight and the number of copies, described
Composition includes：12~17 parts of spirulina, 12~15 parts of dried orange peel, 8~12 parts of golden cypress, 6~10 parts of rheum officinale, 8~12 parts of betel nut is yellow
10~13 parts of stilbene, 18~21 parts of vegetalitas lactic acid bacteria, proteinase 8~15 part.
3. the composition as claimed in claim 2 for being used to prevent and treat swine enteritis, it is characterised in that count by ratio of weight and the number of copies, described
Composition includes：12~15 parts of spirulina, 15 parts of dried orange peel, 8~10 parts of golden cypress, 10 parts of rheum officinale, 8~10 parts of betel nut, 9 parts of the Radix Astragali,
21 parts of vegetalitas lactic acid bacteria, 12 parts of protease.
4. the composition as claimed in claim 1 for being used to prevent and treat swine enteritis, it is characterised in that characterized in that, the plant
Lactic acid bacteria is lactobacillus plantarum.
5. prepare the method for preventing and treating swine enteritis composition as described in any one of Claims 1 to 4, it is characterised in that institute
Preparation method is stated to comprise the following steps：
By spirulina, dried orange peel, golden cypress, rheum officinale, betel nut, the Radix Astragali, vegetalitas lactic acid bacteria and protease are added to closed fermentation
In tank；
Water vapour is passed through to the closed fermenter, the closed fermenter relative humidity is reached more than 85%；
After fermentation under conditions of temperature is 35 DEG C~45 DEG C 40~60 hours, anaerobic fermentation 60~100 hours；
Dry the composition after anaerobic fermentation.
6. method as claimed in claim 5, it is characterised in that will plant spirulina, dried orange peel, golden cypress, rheum officinale, Bin by described
Bulky, the Radix Astragali, vegetalitas lactic acid bacteria and protease are further comprising the steps of before being added to the step in closed fermenter：
By spirulina, dried orange peel, golden cypress, rheum officinale, betel nut, the Radix Astragali, vegetalitas lactic acid bacteria and protease are crushed respectively.
7. method as claimed in claim 5, it is characterised in that after the step of composition after the dry anaerobic fermentation also
Including：
Dried composition powder is broken to 100~250 mesh.
8. a kind of being used for as described in any one of Claims 1 to 4 prevents and treats the application method of the composition of swine enteritis, its feature exists
In, the composition for preventing and treating swine enteritis is added in pig feed and used, wherein, the group for being used to prevent and treat swine enteritis
The weight ratio of compound and pig feed is 1:400~550.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450241A (en) * | 2020-04-23 | 2020-07-28 | 中山市伟健生物科技有限公司 | Composition for improving immunity of livestock |
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| CN114652765A (en) * | 2022-04-08 | 2022-06-24 | 黑龙江省农业科学院畜牧研究所 | Natural plant glycolysis product for preventing and controlling enteritis of pigs as well as preparation method and application thereof |
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