CN116172196A - A health beverage containing extract of semen Viciae Fabae (with pod) - Google Patents
A health beverage containing extract of semen Viciae Fabae (with pod) Download PDFInfo
- Publication number
- CN116172196A CN116172196A CN202111438368.2A CN202111438368A CN116172196A CN 116172196 A CN116172196 A CN 116172196A CN 202111438368 A CN202111438368 A CN 202111438368A CN 116172196 A CN116172196 A CN 116172196A
- Authority
- CN
- China
- Prior art keywords
- extract
- pod
- parts
- broad bean
- health
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000284 extract Substances 0.000 title claims abstract description 41
- 235000013361 beverage Nutrition 0.000 title claims abstract description 22
- 210000000582 semen Anatomy 0.000 title description 6
- 235000010749 Vicia faba Nutrition 0.000 claims abstract description 24
- 240000006677 Vicia faba Species 0.000 claims abstract description 24
- 235000002098 Vicia faba var. major Nutrition 0.000 claims abstract description 24
- 241000196324 Embryophyta Species 0.000 claims abstract description 21
- 206010034010 Parkinsonism Diseases 0.000 claims abstract description 13
- 208000027089 Parkinsonian disease Diseases 0.000 claims abstract description 11
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 241001673966 Magnolia officinalis Species 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 241000305491 Gastrodia elata Species 0.000 claims description 5
- 241000112528 Ligusticum striatum Species 0.000 claims description 5
- 244000197580 Poria cocos Species 0.000 claims description 5
- 235000008599 Poria cocos Nutrition 0.000 claims description 5
- 235000006533 astragalus Nutrition 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 3
- 241000382455 Angelica sinensis Species 0.000 claims description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 3
- 229960004998 acesulfame potassium Drugs 0.000 claims description 3
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 3
- 239000000619 acesulfame-K Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 229940124274 edetate disodium Drugs 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000004744 fabric Substances 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 3
- 229940001584 sodium metabisulfite Drugs 0.000 claims description 3
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 239000009636 Huang Qi Substances 0.000 claims description 2
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 2
- 241001061264 Astragalus Species 0.000 claims 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 1
- 235000011477 liquorice Nutrition 0.000 claims 1
- 210000004233 talus Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 229940069765 bean extract Drugs 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 241000699670 Mus sp. Species 0.000 description 19
- HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 description 9
- 206010044565 Tremor Diseases 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 239000007928 intraperitoneal injection Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 241000045403 Astragalus propinquus Species 0.000 description 4
- 101001135571 Mus musculus Tyrosine-protein phosphatase non-receptor type 2 Proteins 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- JSUAJTLKVREZHV-UHFFFAOYSA-N 1-[4-(1-pyrrolidinyl)but-2-ynyl]pyrrolidine Chemical compound C1CCCN1CC#CCN1CCCC1 JSUAJTLKVREZHV-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 2
- JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 description 2
- MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 230000009194 climbing Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000074 effect on parkinson Effects 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 2
- 230000000415 inactivating effect Effects 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 206010061592 cardiac fibrillation Diseases 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000000105 effect on tremor Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002600 fibrillogenic effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L11/00—Pulses, i.e. fruits of leguminous plants, for production of food; Products from legumes; Preparation or treatment thereof
- A23L11/60—Drinks from legumes, e.g. lupine drinks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Botany (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Agronomy & Crop Science (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
The invention discloses a health-care beverage for improving parkinsonism, which comprises active ingredients of broad bean (with pod) extract and natural plant mixed extract, wherein the proportion of the two is (1-8): 1, a step of; the natural plant mixed extract comprises the following components in percentage by weight: compared with the prior art, the health care beverage prepared by the invention has the advantages that after the natural plant combined extract and the broad bean (with pod) extract are combined, the synergistic effect is exerted, the function singleness effect of the active ingredients of a single broad bean extract is compensated, and the health care beverage is more suitable for the health care needs of parkinsonism.
Description
Technical Field
The invention relates to a health-care beverage containing broad bean (with pod) extract and a preparation method thereof, belonging to the technical field of health-care products.
Background
In recent years, the research on the physiological activities of levodopamine, procyanidine and flavonoid substances extracted from broad beans is more and more increasing, the procyanidine has the physiological activities of antioxidation, bacteriostasis, anticancer, mutation resistance and the like, the flavonoid substances also have the effects of reducing blood fat, resisting arteriosclerosis, resisting tumors, resisting osteoporosis and the like, and people always have the habit of eating the broad beans to relieve the parkinsonism.
However, the single broad bean extract health care product has single efficacy and cannot provide comprehensive health care function, and the invention adds various natural substances with homology of medicine and food, expands the efficacy range of the broad bean extract health care product through the synergistic effect of natural components, and provides richer choices for parkinsonism.
Disclosure of Invention
The object of the invention is achieved in this way.
A health beverage for improving Parkinson syndrome comprises extract of semen Viciae Fabae (with pod) and natural plant mixed extract as active ingredients.
The natural plant mixed extract comprises the following plant components in percentage by weight: 10-15 parts of gastrodia elata, 10-15 parts of astragalus membranaceus, 5-10 parts of angelica sinensis, 2-3 parts of ligusticum wallichii, 3-5 parts of magnolia officinalis, 5-10 parts of poria cocos, and 1-2 parts of honey-fried licorice root.
The preparation method of the health care beverage containing broad bean (with pod) extract comprises the following steps:
the preparation method of the broad bean (with pod) extract comprises the following steps: screening fresh semen Viciae Fabae (with pod), weighing, cleaning, boiling with 1-2 times of water for inactivating enzyme for 1min, filtering to remove water, squeezing, and filtering with 400 mesh filter cloth. Adding 0.01% -0.05% sodium metabisulfite and 0.05-0.2% edetate disodium into the filtrate to obtain extract of semen Viciae Fabae (containing pod).
The preparation method of the mixed extract of other natural plants comprises the following steps: adding rhizoma Gastrodiae, radix astragali, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, cortex Magnolia officinalis, poria, and radix Glycyrrhizae Preparata into an extraction tank, adding 5-10 times of water, soaking for 0.5-1.0 hr, boiling, timing, decocting for 2 hr, and discharging decoction; adding 5-10 times of food water, decocting for 90min, and discharging decoction. Mixing the decoctions, filtering with gauze, and concentrating the filtrate under reduced pressure to obtain extract with density of 1.1-1.3.
Mixing broad bean (with pod) extract and other natural plant mixed extract at a certain ratio (1-8): 1, adding acesulfame potassium 0.05% -0.1%, and packaging after instant killing to obtain the health product beverage.
The parkinsonism belongs to the category of 'tremor' in traditional Chinese medicine, and the disease is located in the brain and relates to liver, kidney and spleen. The pathogenesis of the disease is the deficiency of liver and kidney and the deficiency of qi and blood, and generally adopts the methods of nourishing liver and kidney, tonifying qi and nourishing blood, calming endogenous wind and stopping fibrillation.
In the invention, the gastrodia elata is a monarch drug, the gastrodia elata has the effects of calming endogenous wind and relieving spasm, suppressing liver yang, dispelling wind and dredging collaterals, the astragalus membranaceus is a ministerial drug, the astragalus membranaceus has the effects of tonifying qi and strengthening exterior, expelling toxin and expelling pus, the magnolia officinalis, the poria cocos and the ligusticum wallichii are adjuvant drugs, the poria cocos has the effects of strengthening spleen and earth, promoting blood circulation in the afterweather, the magnolia officinalis has the effects of regulating qi and relaxing bowels, preventing qi movement stagnation, the ligusticum wallichii has the effects of promoting blood circulation and activating qi, and can promote the circulation of qi and dissipate the energy, ascend the head and eyes, bypass the four limbs, descend blood seas and smooth qi and blood circulation. The three are combined to promote qi and blood circulation and to dredge collaterals. Radix Glycyrrhizae Preparata is used as a guiding drug to harmonize the drugs, invigorate spleen and replenish qi. After the natural plant combination extract is combined with the broad bean (with pod) extract, the synergistic effect is exerted, the function singleness effect of the active ingredients of the single broad bean extract is compensated, and the natural plant combination extract is more suitable for the health care needs of parkinsonism.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Example 1: preparation of health-care beverage
The preparation method of the broad bean (with pod) extract comprises the following steps: screening fresh semen Viciae Fabae (with pod), weighing 16.3kg, cleaning, boiling with 1-2 times of water for inactivating enzyme for 1min, filtering to remove water, squeezing, and filtering with 400 mesh filter cloth. Adding 0.01% sodium metabisulfite and 0.2% edetate disodium into the filtrate to obtain broad bean (containing pod) extract.
The preparation method of the mixed extract of other natural plants comprises the following steps: adding 12 parts of gastrodia elata, 12 parts of astragalus membranaceus, 8 parts of angelica sinensis, 2 parts of ligusticum wallichii, 3 parts of magnolia officinalis, 5 parts of poria cocos and 1 part of honey-fried licorice root into an extraction tank, adding 8 times of water of the total weight of the plants, soaking for 0.5 hour, boiling the soaked plants, starting timing, decocting for 2 hours, and discharging a decoction; adding 5 times of food water, decocting for 90min, and discharging decoction. Mixing the decoctions, filtering with gauze, and concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.17 at 25deg.C.
Taking 4 parts of broad bean (with pod) extract and 1 part of other natural plant mixed extract, adding 0.05% acesulfame potassium and 0.05% potassium sorbate, and packaging into 50 ml/bottle after 30s of instant killing at 130 ℃ to obtain the health-care product beverage containing broad bean (with pod) extract.
Example 2: pharmacodynamic experiments
Adult healthy mice were taken in 30 groups, which were divided into blank groups, model groups, test groups 3, and 10 groups each.
Experimental grouping: adult mice were taken 30, 3 groups of 10, and a blank group (normal saline lavage 1-21d, normal saline intraperitoneal injection 22-29 d), a model group (normal saline lavage 1-21d, MPTP (injection: MPTP is 1-methyl-4-phenyl-1, 2,3, 6-tetrahydropyridine, the same applies hereinafter)) 22-29d, and a dosing group (health drink 1-21d of the present invention, MPTP 22-29 d)
Dosage and mode of administration: normal saline (lavage/intraperitoneal injection): 30mg/kg/d
Health beverage (stomach irrigation): 1ml/kg of beverage was prepared as in example 1.
MPTP (intraperitoneal injection): 30mg/kg/d
Frequency of administration: once a day
The behavioral method is used for detecting:
pole climbing experiment: a smooth wood rod with a diameter of 1cm and a height of 50cm and a wood ball with a diameter of 3cm at the top is taken. The mice to be tested were placed on cork pellets during the test, and the time required for the mice to climb to the bottom of the pole was recorded and statistically analyzed. All mice were assayed for pole-climbing time on day 21 of dosing and again after 1h of dosing on day 29.
Rotating shaft experiment: the mice were placed on the rotating stick and the time from the beginning of rotation of the test mice to the falling off the rotating stick was measured. Spindle time was measured for all mice on day 21 of dosing and for 1 hour after dosing on day 29.
Grip strength experiment: the tested mice are placed on a tensile tester, the tail parts of the mice are grasped, the mice are pulled backwards in a straight line, and the grabbing force data are recorded. All mice were measured for grip size on day 21 of dosing and their tension again after dosing on day 29.
Efficacy results:
from the data, it can be seen that: through the Parkinson model of the mice, the administration group can obviously increase the pole climbing time and the rotating shaft time of the mice in the model group and increase the pulling force of the mice. The health-care product beverage has obvious treatment effect on Parkinson model mice.
Example 3: pharmacodynamic experiments
Adult healthy mice were taken in 30 groups, which were divided into blank groups, model groups, test groups 3, and 10 groups each.
Experimental grouping: taking 30 adult mice, dividing the mice into 3 groups, 10 blank control groups (physiological saline lavage 1-21d, physiological saline intraperitoneal injection 22-21 d), model group 1 (physiological saline lavage 1-21d, arecoline modeling), model group 2 (physiological saline lavage 1-21d, oxidation tremorine modeling), and administration group (health care beverage 1-21d, arecoline modeling).
Dosage and mode of administration: normal saline (lavage/intraperitoneal injection): 30mg/kg/d
Health beverage (stomach irrigation): 1ml/kg of beverage was prepared as in example 1.
Betulin (intraperitoneal injection): 30mg/kg/d
Oxidative tremorine (intraperitoneal injection): 0.30mg/kg/d
Frequency of administration: once a day
The behavioral method is used for detecting: the time required for each mouse to develop until disappearance of the visually apparent muscle tremor was recorded as the tremor duration.
Efficacy results:
from the data, it can be seen that: obvious tremors appear after the mice are intraperitoneally injected with arecoline and oxitremors, and the tremors of arecoline groups are longer. However, the administration groups given in advance with the health drink prepared by the invention have obvious shortened duration of tremors, which indicates that the health drink of the invention has obvious improving effect on tremors simulating parkinsonism. The betulin beverage has the effect of relieving tremors formed by arecoline modeling and tremors formed by oxytremors modeling, and has obvious treatment effect on Parkinson model mice.
Claims (5)
1. A health beverage for improving Parkinson syndrome is characterized in that the active ingredients are broad bean (with pod) extract and natural plant mixed extract.
2. The health drink for improving parkinsonism according to claim 1, wherein the plant components in the natural plant mixed extract are as follows by weight ratio: 10-15 parts of gastrodia elata, 10-15 parts of astragalus, 5-10 parts of angelica sinensis, 2-3 parts of ligusticum wallichii, 3-5 parts of magnolia officinalis, 5-10 parts of poria cocos, and 1-2 parts of liquorice.
3. The health drink for preventing and treating parkinsonism according to claim 1, wherein the weight ratio of the extract of broad bean (pod) to the mixed extract of other natural plants is (1-8): 1.
4. the health beverage for preventing and treating parkinsonism according to claim 1, which is prepared by the following method: the preparation method of the broad bean (with pod) extract comprises the following steps: screening fresh broad beans (with pods), weighing, cleaning, boiling with 1-2 times of water for de-enzyming for 1min, filtering to remove water, squeezing juice, filtering the squeezed juice with 400-mesh filter cloth, adding 0.01% -0.05% sodium metabisulfite and 0.05-0.2% edetate disodium into the filtrate to obtain broad bean (containing pods) extract; the preparation method of the natural plant mixed extract comprises the following steps: adding rhizoma Gastrodiae, radix astragali, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, cortex Magnolia officinalis, poria, and Glycyrrhrizae radix into an extraction tank, adding 5-10 times of water, soaking for 0.5-1.0 hr, boiling, timing, decocting for 2 hr, and discharging decoction; adding 5-10 times of food water, continuously decocting for 90min, and discharging decoction; mixing the decoctions, filtering with gauze, concentrating the filtrate under reduced pressure to obtain extract with relative density of 1.1-1.3 at 25deg.C; mixing broad bean (with pod) extract and other natural plant mixed extract, adding acesulfame potassium 0.05-0.1%, potassium sorbate 0.05-0.1%, and packaging after instant killing to obtain health beverage.
5. The health beverage for preventing and treating parkinsonism according to claim 1, wherein the weight ratio of the extract of broad bean (pod) to the mixed extract of other natural plants in the preparation method is (1-8): 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111438368.2A CN116172196A (en) | 2021-11-28 | 2021-11-28 | A health beverage containing extract of semen Viciae Fabae (with pod) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111438368.2A CN116172196A (en) | 2021-11-28 | 2021-11-28 | A health beverage containing extract of semen Viciae Fabae (with pod) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116172196A true CN116172196A (en) | 2023-05-30 |
Family
ID=86440973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111438368.2A Pending CN116172196A (en) | 2021-11-28 | 2021-11-28 | A health beverage containing extract of semen Viciae Fabae (with pod) |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116172196A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030037581A (en) * | 2001-11-06 | 2003-05-14 | 이태숙 | manufacturing process of healthy drink |
| CN1739743A (en) * | 2005-01-19 | 2006-03-01 | 广东众生药业股份有限公司 | Medicine for treating parkinson's disease and Parkinson's syndrome and its prepn |
| CN102934799A (en) * | 2012-11-16 | 2013-02-20 | 南京艾德凯腾生物医药有限责任公司 | Healthcare product containing broad bean extracts and application of healthcare product |
| KR20140018597A (en) * | 2012-08-02 | 2014-02-13 | (주)아모레퍼시픽 | Composition for antiinflammation containing extract of soybean pod |
| EP3225245A1 (en) * | 2016-03-29 | 2017-10-04 | Ramon Cacabelos Garcia | Bioactive extract obtained from vicia faba and its use in the treatment and/or prevention of neurodegenerative diseases |
| US10300100B1 (en) * | 2018-09-27 | 2019-05-28 | King Saud University | Extract of Vicia faba beans |
-
2021
- 2021-11-28 CN CN202111438368.2A patent/CN116172196A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030037581A (en) * | 2001-11-06 | 2003-05-14 | 이태숙 | manufacturing process of healthy drink |
| CN1739743A (en) * | 2005-01-19 | 2006-03-01 | 广东众生药业股份有限公司 | Medicine for treating parkinson's disease and Parkinson's syndrome and its prepn |
| KR20140018597A (en) * | 2012-08-02 | 2014-02-13 | (주)아모레퍼시픽 | Composition for antiinflammation containing extract of soybean pod |
| CN102934799A (en) * | 2012-11-16 | 2013-02-20 | 南京艾德凯腾生物医药有限责任公司 | Healthcare product containing broad bean extracts and application of healthcare product |
| EP3225245A1 (en) * | 2016-03-29 | 2017-10-04 | Ramon Cacabelos Garcia | Bioactive extract obtained from vicia faba and its use in the treatment and/or prevention of neurodegenerative diseases |
| US10300100B1 (en) * | 2018-09-27 | 2019-05-28 | King Saud University | Extract of Vicia faba beans |
Non-Patent Citations (2)
| Title |
|---|
| "从蚕豆荚皮中提取左旋多巴", 卫生研究, no. 01, pages 6 - 8 * |
| 张希廉;田军彪;耿百乐;石玫;顾平;: "抗颤宁方对帕金森病大鼠行为学及脂质过氧化的影响", 河北中医, no. 03, pages 441 - 443 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104388265B (en) | A kind of kidney-nourishing health tonic wine and preparation method thereof | |
| CN1895575B (en) | Medicine for treating infantile anorexia and its preparation | |
| CN103007215B (en) | Chinese medicinal composition for treating edema | |
| CN105686006A (en) | Oyster compound functional food and preparation method thereof | |
| CN104587194A (en) | Yin-nourishing and lung-moistening traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN107853517B (en) | Traditional Chinese medicine beverage capable of refreshing and resisting fatigue and preparation method thereof | |
| CN101961401B (en) | Compound Chinese medicinal composition having effects of reducing weight, reducing fat, tonifying spleen and beautifying | |
| CN106309645B (en) | A pharmaceutical composition with antidepressant effect | |
| CN101745087A (en) | Composition with effects of relieving alcoholism and preventing drunkenness and preparation method thereof | |
| CN107412665B (en) | It is a kind of that there is Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury and its preparation method and application | |
| CN101244208B (en) | Method of preparing traditional Chinese medicine preparation for treating melancholia and anxiety neurosis | |
| CN102357208B (en) | Traditional Chinese medicine composition for treating diabetes, hyperglycemia, hypertension, and hyperlipidemia | |
| CN105833011A (en) | Healthcare medicinal liquor | |
| CN105250873A (en) | Traditional Chinese medicine composition for treating pregnancy vomiting | |
| CN105497789A (en) | Traditional Chinese medicine preparation for treating poststroke depression and preparation method of traditional Chinese medicine preparation | |
| CN116172196A (en) | A health beverage containing extract of semen Viciae Fabae (with pod) | |
| CN104397282A (en) | Tranquilization and brain tonifying eleutherococcus senticosus healthare tea and preparation method thereof | |
| CN104474251A (en) | Composition with functions of strengthening brain and consolidating constitution and preparation and application of composition | |
| CN104126706A (en) | Arrhythmia-conditioning tea | |
| CN104524479B (en) | A kind of Chinese medicine composition for treating premenstrual syndrome and preparation method thereof | |
| CN105232958A (en) | Traditional Chinese medicine combination for preparing medicine for treating myasthenia gravis | |
| CN105831751B (en) | Traditional Chinese medicine health-care composition for tonifying qi and strengthening brain, preparation method and use method thereof | |
| CN103705730A (en) | Bone strengthening pawpaw wine and preparation method thereof | |
| CN105998996A (en) | Medicinal liquor and preparation method thereof | |
| CN105012847A (en) | Traditional Chinese medicine for preventing miscarriages and reinforcing uteri |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |