CN105686006A - Oyster compound functional food and preparation method thereof - Google Patents
Oyster compound functional food and preparation method thereof Download PDFInfo
- Publication number
- CN105686006A CN105686006A CN201610072106.1A CN201610072106A CN105686006A CN 105686006 A CN105686006 A CN 105686006A CN 201610072106 A CN201610072106 A CN 201610072106A CN 105686006 A CN105686006 A CN 105686006A
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- concha ostreae
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Abstract
The invention discloses an oyster compound functional food. The oyster compound functional food is prepared from the following raw materials in parts by weight: 5-15 parts of oyster peptide powder, 1-3 parts of ginsengs, 2-6 parts of herba epimedii, 2-6 parts of rhodiola rosea, 2-5 parts of wolfberry fruits and 3-6 parts of eucommia ulmoides. The invention further discloses a preparation method of the oyster compound functional food. With the adoption of the formula of the invention, all the raw materials have a very good synergistic effect and the curative effect of a composition can be expressed very well, so that each traditional Chinese medicine expresses a unique effect; and the oyster compound functional food has a remarkable effect of relieving physical fatigue.
Description
Technical field
The present invention relates to technical field of aquatic product processing, be specifically related to seed oyster composite function food and preparation method thereof。
Background technology
In the health food of China's approval, fatigue resistant health food quantity comes the 3rd, it is sufficient to embody the actual demand to resisting fatigue。At first, it is believed that fatigue is a series of intoxicating phenomenons caused because of body cell generation chemical change, the even whole body ability to work of exhibit tissue, organ declines。Along with the exploration deeply with to tired mechanism of research, the organism physiology process that fatigue is defined as by body movement itself is caused by final scientist can not continue the phenomenon that its function maybe can not maintain predetermined exercise intensity at specified level and cause motor capacity to decline。
Concha Ostreae is Fresh & Tender in Texture, delicious flavour, has abundant nutritive value, is known as " marine milk "。Modern scientific research shows that Carnis ostreae contains rich in protein, glycogen, taurine and trace element, has the effects such as resisting fatigue, antioxidation, blood sugar lowering and antitumor, acts not only as food, also have great medical value。Concha Ostreae Ye Shi China first be food and one of the food materials of medicine。
Being extracted by complex enzyme hydrolysis from natural marine product Concha Ostreae and obtain Concha Ostreae polypeptide, the physiological action of further research oyster active peptides, exploitation Concha Ostreae health product are significant。
Summary of the invention
It is an object of the invention to provide seed oyster composite function food and preparation method thereof, this functional food is with Concha Ostreae Gly-His-Lys for primary raw material, reasonably combined in conjunction with 5 taste extracts, has good antifatigue effect。
For achieving the above object, the present invention is by the following technical solutions:
One seed oyster composite function food, makes including following raw material: Concha Ostreae Gly-His-Lys 5～15 parts, Radix Ginseng 1～3 part, Herba Epimedii 2～6 parts, Radix Rhodiolae 2～6 parts, Fructus Lycii 2～5 parts, the Cortex Eucommiae 3～6 parts。
Radix Ginseng: another name Radix Ginseng Sativus, Sphallerocarpus gracilis, wooden club, people's rank, Coprinus atramentarius (Bull.) Fr. (Coprinus sterquilinus Fr.), SHENCAO, Rhizoma Panacis Japonici, Herba Stellariae Saxatilis, genus Angiospermae have pipe embryophyte subphylum, Magnoliatae, Rosidae, Umbellales, Araliaceae, Radix Ginseng race, Panax。For rare Chinese medicine, property is put down, sweet in the mouth, micro-hardship。For body empty soft de-, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung are breathed with cough, Tianjin wound thirsty, interior-heat is quenched one's thirst, prolonged illness is empty, palpitation with fear insomnia, sexual impotence cold womb, heart failure, cardiogenic shock。Experimentation in the resisting fatigue of Radix Ginseng shows to be respectively provided with obvious effect in Radix Ginseng is to the resisting fatigue of animal, anoxia enduring, anti-stress and haematochrome increasing etc.。Radix Ginseng can strengthen mice hypoxia-bearing capability, and walking weight load extends, and antioxidation is one of reason improving fatigue resistance。The mechanism of Anti-Fatigue Effects of Panax ginseng is likely to raise blood fat with it and promote that protein, RNA synthesis are relevant。Research shows ginsenoside and lipotropic component, can increase the autonomic movement of mice, shows antifatigue effect。
Herba Epimedii: Herba Epimedii is the tonification article of Chinese tradition, and history tree is all on the books, nature and flavor acrid, sweet, warm；Return liver, kidney channel；There is kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling；For kidney yang deficiency, impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture。Herba Epimedii, with epimedium flavone for main component, has got tens of kinds of flavones ingredients, so far including icariin。Herba Epimedii is possibly together with epimedium brevicornum polysaccharide。The Aqueous extracts of Folium Epimedii has obvious effect of scavenging radical。It is reported that the biochemical indicators such as Hb, Glue, BLA, BUN before and after Athletes are all had beneficial effect by flavones ingredient magnoflorine in Herba Epimedii, and make cardiovascular system be in hyperkinetic state, being beneficial to athlete's long period maintains high-intensity exercise ability, and has the effect of resisting kinetic fatigue。
Radix Rhodiolae: for Crassulaceae renascent herb or shrub plant, is classified as in medicine by Radix Rhodiolae in Shennong's Herbal top grade。Sweet, bitter, flat, return lung, heart channel。Having benefiting QI for activating blood circulation, effect relievingd asthma of promoting blood circulation, for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted。Modern pharmacological research shows, Radix Rhodiolae can strengthen exercise tolerance, antioxidation, anti-diabetic, anti-pneumonia and asthma, the effect such as anticancer。
Fructus Lycii: Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL., wild and cultivation all has, and is distributed in the ground such as North China, northwest, and also there is cultivation in other areas。Fructus Lycii master is containing lycium barbarum polysaccharide, and it has biologic activity widely。Sterling lycium barbarum polysaccharide can significantly increase Mouse Muscle glycogen, liver glycogen reserves amount；Serum lactate dehydrogenase (SLD) total activity after improving before motion and swimming；Serum urea nitrogen increment after reduction mice strenuous exercise, accelerates the regeneration rate of blood urea nitrogen after moving。Result shows that the adaptive capacity of sports load, resisting fatigue are produced and have fairly obvious effect in the elimination that accelerates fatigue improving body by sterling lycium barbarum polysaccharide。Being shown by crowd's test, lycium barbarum has reduction Serum lactic acid content effect, has anti-exercise fatigue effect。
The Cortex Eucommiae: for famous Chinese crude drug, is peculiar Dan Shu section of China, autogenus plant。Theoretical according to chinese tradition integration of edible and medicinal herbs, Compendium of Material Medica is recorded, and human body is had the health-care effect of " QI invigorating, hard muscles and bones " by the Cortex Eucommiae。The Chinese patent medicine made by the Cortex Eucommiae, successive dynasties medical book also more discussion: says in " longevity parent support parents new book ", Cortex Eucommiae ball beard and hair first, black under mending, strengthens foot knee joint, improving healthy complexion, takes anti-aging for a long time。Saying in " Shengji Zonglu ", Cortex Eucommiae drink can the kidney warming be positive, bone and muscle strengthening, it is adaptable to year the old and the weak's insufficiency of kidney-YANG, chills and pain of the waist and kness unable, curative effect is rather good。Saying in " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House opinion ", " Huanshao pill " (is formed by medicinal material processings such as the Cortexs Eucommiae), has the merit of invigorating the liver and kidney, audition improvement, improving eyesight, body-building, and by heart kidney deficiency, essence and blood is deficient, health is empty, the dark tinnitus person of order is commonly used。The Cortex Eucommiae has invigorating the liver and kidney, bone and muscle strengthening, anti-senility, controls the effects such as lumbago, and modern pharmacology proves that the Cortex Eucommiae has blood pressure lowering, strengthens many-sided pharmacological actions such as immune, strong, anticancer, anti peroxidation of lipid。Confirm through animal tissue's decomposition experiment, mice mice after taking Cortex Eucommiae decocting liquid shows that the feature in skeletal muscle micro structure is that connective tissue is flourishing, fibroblast activity is vigorous, collagen fiber increasing number, mitochondrion and sarcoplasmic reticulum substantially enrich, when this and muscle contraction, the supply of energy and the offer of Ca++ adapt, also it is the architecture basics improving motor capacity, thus can promote that collagen protein synthesis and comprehensive aspects such as motor capacity that improve provide direct morphological evidence for the Cortex Eucommiae。The swimming with a load attached to the body experimentation of mice is also indicated that, eucommia wine extract can effectively extend walking weight load, improves body glycogen deposit or reduce the consumption of glycogen, the enhancing body adaptive capacity to sports load during motion。Therefore the Cortex Eucommiae has antifatigue effect。
The preparation method that the invention also discloses above-mentioned Concha Ostreae composite function food, comprises the following steps:
S1. take Radix Ginseng, excessive sheep, Radix Rhodiolae, Fructus Lycii, the Cortex Eucommiae according to the weight proportion of claim 1 and make powdery。
S2. prepare Concha Ostreae Gly-His-Lys according to the following steps: (1) takes making beating after the cleaning of fresh Concha Ostreae drains, add the water stirring of 2 times of volumes；(2) adding trypsin 7500U/g, flavor protease 450U/g, adjustment pH is 8.0, and temperature is 40 DEG C～60 DEG C, reacts 3h～4h, to supernatant and precipitation boundary clear, centrifugal extraction supernatant；(3) by supernatant obtained above by ceramic membrane remove impurity, it is the little molecule Concha Ostreae Gly-His-Lys between 300～10000Da that ultrafiltration membrance filter obtains molecular weight；(4) little molecule Concha Ostreae Gly-His-Lys is concentrated by NF membrane, finally spray-dried obtains Concha Ostreae Gly-His-Lys。
The Concha Ostreae Gly-His-Lys that the Radix Ginseng of the powdery S3. obtained by step S1, excessive sheep, Radix Rhodiolae, Fructus Lycii, the Cortex Eucommiae and step S2 obtain is mixed to get composition powder according to weight proportion。
S4. the composition powder obtained is prepared with customary adjuvant capsule or oral liquid or tablet。
Wherein, in step S1, to make the process of powdery as follows for each raw material: takes the dry Cortex Eucommiae, Fructus Lycii and Radix Rhodiolae mixing, adds the water of 6 times of volumes, heating and refluxing extraction, keep 2h, decoct and extract 2 times after reaching slight boiling condition, first time extract before soak；Merging 2 decoction liquor, filter, concentrate with Rotary Evaporators, temperature controls at 50 DEG C～70 DEG C, obtains just cream, is lyophilized into powdery；Take dry Radix Ginseng and Herba Epimedii mixing, pulverize, cross 40 mesh sieves, add volume after sieving to be 6～10 times of mass concentrations of volume of mixture be the alcohol reflux 2 times of 80%, recycling design, the paste obtained precipitation is lyophilized into powdery。
Wherein, step S2 small molecular Concha Ostreae Gly-His-Lys is concentrated into solid content by NF membrane and reaches 10%, last spray drying, and the inlet temperature controlling spraying is 180 DEG C, and leaving air temp is 80 DEG C, obtains activity Concha Ostreae Gly-His-Lys, uses initial vacuum packaging cryopreservation。
Further, in step S4, the preparation process of capsule is: the composition powder obtained by step S3 crosses 80 mesh sieves, is fabricated to soft material with the ethanol that mass concentration is 85%, 16 mesh sieves are granulated, and dry at 50 DEG C～60 DEG C temperature, 14 mesh sieve granulate, load capsule shells, obtain capsule finished product。
After adopting technique scheme, present invention have the advantage that the present invention is with Concha Ostreae Gly-His-Lys for primary raw material, reasonably combined in conjunction with 5 taste extracts, the formula provided makes various raw material serve good potentiation, namely each Chinese medicine plays effect of its uniqueness, and the effect in alleviating physical fatigue that combines is more notable, and prescription more optimizes, that is extracted by active component is more complete, plays the curative effect of compositions better；And have no adverse reaction, the property of medicine is gentle, and long-term taking safety is significantly high。The equipment of preparation is simple, less costly, it is possible to realize industrialized production。
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated。
The invention discloses a seed oyster composite function food, with Concha Ostreae Gly-His-Lys for primary raw material, in conjunction with 5 taste extracts。Its formula is as shown in table 1 below。
Table 1. Concha Ostreae composite function food list of ingredients
| Group | Concha Ostreae Gly-His-Lys (g) | Radix Ginseng (g) | Herba Epimedii (g) | Radix Rhodiolae (g) | Fructus Lycii (g) | The Cortex Eucommiae (g) |
| One group | 5 | 1 | 2 | 2 | 2 | 3 |
| Two groups | 10 | 1 | 3 | 4 | 3 | 5 |
| Three groups | 15 | 3 | 6 | 6 | 5 | 6 |
The invention also discloses the preparation process of above-mentioned Concha Ostreae composite function food, comprise the following steps:
S1. take Radix Ginseng, excessive sheep, Radix Rhodiolae, Fructus Lycii, the Cortex Eucommiae according to the weight proportion of table 1 and make powdery。Specific as follows:
(1) take the dry Cortex Eucommiae, Fructus Lycii and Radix Rhodiolae mixing, add the water of 6 times of volumes, heating and refluxing extraction, keep 2h after reaching slight boiling condition, decoct and extract 2 times, first time extract before soak；Merging 2 decoction liquor, filter, concentrate with Rotary Evaporators, temperature controls at 50 DEG C～70 DEG C, obtains just cream, is lyophilized into powdery。
(2) take dry Radix Ginseng and Herba Epimedii mixing, pulverize, cross 40 mesh sieves, add volume after sieving to be 6～10 times of mass concentrations of volume of mixture be the alcohol reflux 2 times of 80%, recycling design, the paste obtained precipitation is lyophilized into powdery。
S2. Concha Ostreae Gly-His-Lys is prepared according to the following steps:
(1) take making beating after the cleaning of fresh Concha Ostreae drains, add the water stirring of 2 times of volumes。
(2) adding trypsin 7500U/g, flavor protease 450U/g, adjustment pH is 8.0, and temperature is 40 DEG C～60 DEG C, reacts 3h～4h, to supernatant and precipitation boundary clear, centrifugal extraction supernatant。
(3) by supernatant obtained above by ceramic membrane remove impurity, it is the little molecule Concha Ostreae Gly-His-Lys between 300～10000Da that ultrafiltration membrance filter obtains molecular weight。
(4) little molecule Concha Ostreae Gly-His-Lys reaches 10% by being concentrated into solid content to filter membrane, last spray drying, and the inlet temperature controlling spraying is 180 DEG C, and leaving air temp is 80 DEG C, obtains activity Concha Ostreae Gly-His-Lys, uses initial vacuum packaging cryopreservation。
The Concha Ostreae Gly-His-Lys that the Radix Ginseng of the powdery S3. obtained by step S1, excessive sheep, Radix Rhodiolae, Fructus Lycii, the Cortex Eucommiae and step S2 obtain is mixed to get composition powder according to the weight proportion of table 1。
S4. the composition powder that step S3 obtains being crossed 80 mesh sieves, be fabricated to soft material with the ethanol that mass concentration is 85%, 16 mesh sieves are granulated, and dry at 50 DEG C～60 DEG C temperature, and 14 mesh sieve granulate load capsule shells, obtain capsule finished product。Or oral liquid or tablet is prepared with customary adjuvant。
The Concha Ostreae the composite function food below preparation method using the present invention prepared carries out gavage mouse experiment, by mouse movement index and measuring of biochemical indicator are inquired into the functional food of the present invention active function to mouse anti-reflecting fatigue。
1. animal packet and medication
SPF level male ICR mouse 80, after adaptability feeds one week, is randomly divided into 2 groups according to Mouse Weight, often group 40。Namely blank group, functional food group。Functional food group adopts the oral liquid that in table 1, the formula of two groups prepares。Wherein blank group gavage 0.5ml every day distilled water, functional food group gavage 1.0g/kg every day dosage Concha Ostreae composite function food。Feed mice simultaneously and maintain feedstuff, freely drink water, test after 30d。
2. experimentation
(1) swimming time measures
Per os gives tested material 30d continuously, after last gavage 30min, by the mice of afterbody load 5% body weight sheet lead as swimming trunk went swimming。The depth of water no less than 30cm, water temperature 25 ± 1.0 DEG C, with mouse head sink to the water surface continue 8s can not emersion for judging terminal, record mice starts to dead time, i.e. mice swimming time from swimming。
(2) urea nitrogen content measures
Per os gives tested material 30d continuously, after last gavage 30min, and not swimming with a load attached to the body 90min in the water that temperature is 30 DEG C, pull out eyeball after rest 60min and take blood, after blood coagulation, 2000 leave heart 15min, take serum, measure with blood urea nitrogen testing cassete。
(3) hepatic glycogen content measures
Per os gives tested material 30d continuously, and after last gavage 30min, cervical dislocation is put to death, and takes liver, rinsing through normal saline, filter paper blots, and accurately weighs 100mg liver, add 30 μ L alkali liquor and boil the cooling of rear flowing water, prepare into glycogen detection liquid, measure kit measurement with hepatic glycogen。
(4) Serum lactic acid content measures
Per os gives tested material 30d continuously, makes each group of mice without swimming with a load attached to the body after last gavage 30min in the water tank of water temperature 30 DEG C。Before swimming, swimming 90min, the different time such as rest 60min after swimming, orbital venous plexus takes blood, with kit measurement mice BLA content。
(5) data statistics and analysis
Data analysis adopts SPSS19.0 software carry out one factor analysis of variance and carry out LSD multiple comparisons。
3. experimental result
(1) the Concha Ostreae composite function food impact on Mouse Weight
In process of the test, mice claims a body weight record week about。Table 2, it can be seen that the body weight respectively organizing mice all has the growth of equal extent, illustrates that the impact of the body weight on mice there is no significant difference (p > 0.05), this guarantees mice and avoid when Biochemical Indexes giving the impact that weight differences brings。
Table 2. Concha Ostreae composite function food on the impact of Mouse Weight (n=10,)
(2) the Concha Ostreae composite function food impact on mice swimming time
Swimming time performance is mouse movement endurance size, and the degree that direct reaction is tired, walking weight load is more long, and motor capacity is more strong。Table 3 is it can be seen that gavage is after 30 days continuously, and functional food group mice swimming time is than blank group leader。
Table 3. Concha Ostreae composite function food on the impact of mice swimming time (n=10,)
Note: " * " and blank group ratio, p < 0.05；" * * " and blank group ratio, p < 0.01。
Fatigue refers to that the organism physiology function caused by body movement can not be maintained at normal level and maybe can not maintain its original exercise intensity and show the phenomenon that body movement ability declines。Exercise tolerance can the most directly, the most objectively reflect the degree of fatigue of body, the length of mice heavy burden swimming time, be a kind of stable and conventional evaluation index。This experiments show that, the Concha Ostreae composite function food of the present invention has a degree of antifatigue effect。
(3) the Concha Ostreae composite function food impact on mice serum urea nitrogen content
Table 4 is it can be seen that the continuous relation of each dosage group and mice serum urea nitrogen content after gavage 30d。Compared with blank group, the serum urea nitrogen content of functional food group is lower than blank group (p < 0.01)。
Table 4. Concha Ostreae composite function food on the impact of mice serum urea nitrogen content (n=10,)
Note: " * " and blank group ratio, p < 0.05；" * * " and blank group ratio, p < 0.01。
When body carries out long-time strenuous exercise, when the energy provided by glycogen is not enough to maintain, protein just begins participating in metabolism and provides energy, can significantly rise as metabolite urea nitrogen content, the Concha Ostreae composite function food of the present invention can reduce urea nitrogen content during motion, the generation of delay fatigue state。
(4) the Concha Ostreae composite function food impact on Mouse Liver glycogen content
As can be seen from Table 5, after the continuous gavage of 30d, compared with blank group, functional food group Mouse Liver glycogen content all has increase (p < 0.01) extremely significantly。
Table 5. Concha Ostreae composite function food on the impact of Mouse Liver glycogen content (n=10,)
Note: " * " and blank group ratio, p < 0.05；" * * " and blank group ratio, p < 0.01。
When organism fatigue, internal hepatic glycogen can change into blood glucose in order to make up the consumption of muscle glycogen, so hepatic glycogen content can reduce rapidly。Therefore the deposit content of hepatic glycogen may indicate that body can the tired generation of delayed motion。By this measuring, illustrate that Concha Ostreae composite function food of the present invention can provide enough energy supplement to body, contribute to resisting fatigue under kinestate。
(5) the Concha Ostreae composite function food impact on Mouse Blood lactic acid content
Before motion, mice is in resting state, and internal lactic acid content is in reduced levels。After swimming, owing to mice is in strenuous exercise's state, big energy is needed to supply, require over anaerobic respiration and convert glucose into ATP, anaerobic respiration causes that internal lactic acid content steeply rises, and functional food group mice lactic acid content climbing is low has pole significant difference (p < 0.01) compared with blank group；After rest, internal lactic acid is converted into acetone acid metabolism further under the effect of lactic acid dehydrogenase, and lactate level is gradually lowered again, until recovering normal level, functional food group mice phosphagen system is more than blank group。As shown in table 6。
Table 6. Concha Ostreae composite function food on the impact of Mouse Blood lactic acid content (n=10,)
Table2.10TheeffectedofOysterpeptideonserumlacticacid (n=10,)
Note: " * " and blank group ratio, p < 0.05；" * * " and blank group ratio, p < 0.01。
Under normal circumstances, glycogen is changed into glucose by glycolysis by body, produces ATP again through tricarboxylic acid cycle oxidation Decomposition glucose and provides energy。Under strenuous exercise, energy provides deficiency, will produce lactic acid by anaerobic respiration。In blood, lactic acid content is usually used as the important indicator of detection degree of fatigue。The Concha Ostreae composite function food of the present invention may be by the activity increasing lactic acid dehydrogenase thus promoting the metabolism of lactic acid。
To sum up, the present invention is with Concha Ostreae Gly-His-Lys for primary raw material, and reasonably combined in conjunction with 5 taste extracts, various raw materials play effect of its uniqueness, and in alleviating physical fatigue, effect is notable。
The above; being only the present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, any those familiar with the art is in the technical scope that the invention discloses; the change that can readily occur in or replacement, all should be encompassed within protection scope of the present invention。
Claims (5)
1. a seed oyster composite function food, it is characterised in that include following raw material and make:
Concha Ostreae Gly-His-Lys 5～15 parts, Radix Ginseng 1～3 part, Herba Epimedii 2～6 parts, Radix Rhodiolae 2～6 parts, Fructus Lycii 2～5 parts, the Cortex Eucommiae 3～6 parts。
2. the preparation method of the Concha Ostreae composite function food described in claim 1, it is characterised in that comprise the following steps:
S1. take Radix Ginseng, excessive sheep, Radix Rhodiolae, Fructus Lycii, the Cortex Eucommiae according to the weight proportion of claim 1 and make powdery；
S2. Concha Ostreae Gly-His-Lys is prepared according to the following steps:
(1) take making beating after the cleaning of fresh Concha Ostreae drains, add the water stirring of 2 times of volumes；
(2) adding trypsin 7500U/g, flavor protease 450U/g, adjustment pH is 8.0, and temperature is 40 DEG C～60 DEG C, reacts 3h～4h, to supernatant and precipitation boundary clear, centrifugal extraction supernatant；
(3) by supernatant obtained above by ceramic membrane remove impurity, it is the little molecule Concha Ostreae Gly-His-Lys between 300～10000Da that ultrafiltration membrance filter obtains molecular weight；
(4) little molecule Concha Ostreae Gly-His-Lys is concentrated by NF membrane, finally spray-dried obtains Concha Ostreae Gly-His-Lys；
The Concha Ostreae Gly-His-Lys that the Radix Ginseng of the powdery S3. obtained by step S1, excessive sheep, Radix Rhodiolae, Fructus Lycii, the Cortex Eucommiae and step S2 obtain is mixed to get composition powder according to weight proportion；
S4. the composition powder obtained is prepared with customary adjuvant capsule or oral liquid or tablet。
3. the preparation method of Concha Ostreae composite function food as claimed in claim 2, it is characterized in that, in step S1, to make the process of powdery as follows for each raw material: takes the dry Cortex Eucommiae, Fructus Lycii and Radix Rhodiolae mixing, add the water of 6 times of volumes, heating and refluxing extraction, keep 2h after reaching slight boiling condition, decoct and extract 2 times, soak before first time extraction；Merging 2 decoction liquor, filter, concentrate with Rotary Evaporators, temperature controls at 50 DEG C～70 DEG C, obtains just cream, is lyophilized into powdery；Take dry Radix Ginseng and Herba Epimedii mixing, pulverize, cross 40 mesh sieves, add volume after sieving to be 6～10 times of mass concentrations of volume of mixture be the alcohol reflux 2 times of 80%, recycling design, the paste obtained precipitation is lyophilized into powdery。
4. the preparation method of Concha Ostreae composite function food as claimed in claim 2, it is characterized in that: step S2 small molecular Concha Ostreae Gly-His-Lys is concentrated into solid content by NF membrane and reaches 10%, last spray drying, the inlet temperature controlling spraying is 180 DEG C, leaving air temp is 80 DEG C, obtain activity Concha Ostreae Gly-His-Lys, use initial vacuum packaging cryopreservation。
5. the preparation method of Concha Ostreae composite function food as claimed in claim 2, it is characterized in that, in step S4, the preparation process of capsule is: the composition powder obtained by step S3 crosses 80 mesh sieves, it is fabricated to soft material with the ethanol that mass concentration is 85%, 16 mesh sieves are granulated, and dry at 50 DEG C～60 DEG C temperature, 14 mesh sieve granulate, load capsule shells, obtain capsule finished product。
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| CN106722993A (en) * | 2016-12-23 | 2017-05-31 | 浙江新维士生物科技有限公司 | A kind of functional food composite and oral products and preparation method thereof and their application |
| CN107259409A (en) * | 2017-06-05 | 2017-10-20 | 福建省水产研究所 | Health food containing the pitch-dark pigment of siphonopods and preparation method thereof |
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