CN116137812A - 用于选择性肺部递送的聚(胺-共-酯)聚合物粒子 - Google Patents

用于选择性肺部递送的聚(胺-共-酯)聚合物粒子 Download PDF

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Publication number
CN116137812A
CN116137812A CN202180059479.4A CN202180059479A CN116137812A CN 116137812 A CN116137812 A CN 116137812A CN 202180059479 A CN202180059479 A CN 202180059479A CN 116137812 A CN116137812 A CN 116137812A
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China
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pdgf
macrophages
cells
hypoxia
lung
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Pending
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CN202180059479.4A
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English (en)
Chinese (zh)
Inventor
马克·W·萨尔茨曼
阿格莱亚·恩托库
丹尼尔·格雷夫
艾米·考夫曼
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Yale University
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Yale University
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Publication of CN116137812A publication Critical patent/CN116137812A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202180059479.4A 2020-07-28 2021-07-28 用于选择性肺部递送的聚(胺-共-酯)聚合物粒子 Pending CN116137812A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063057626P 2020-07-28 2020-07-28
US63/057,626 2020-07-28
US17/332,175 2021-05-27
US17/332,175 US20220031633A1 (en) 2020-07-28 2021-05-27 Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
PCT/US2021/043514 WO2022026585A1 (en) 2020-07-28 2021-07-28 Poly(amine-co-ester) polymeric particles for selective pulmonary delivery

Publications (1)

Publication Number Publication Date
CN116137812A true CN116137812A (zh) 2023-05-19

Family

ID=80002419

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180059479.4A Pending CN116137812A (zh) 2020-07-28 2021-07-28 用于选择性肺部递送的聚(胺-共-酯)聚合物粒子

Country Status (10)

Country Link
US (1) US20220031633A1 (https=)
EP (1) EP4188342A1 (https=)
JP (1) JP2023536119A (https=)
KR (1) KR20230047126A (https=)
CN (1) CN116137812A (https=)
AU (1) AU2021315545A1 (https=)
BR (1) BR112023001379A2 (https=)
CA (1) CA3185957A1 (https=)
MX (1) MX2023000850A (https=)
WO (1) WO2022026585A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021293780A1 (en) 2020-06-19 2023-02-02 Yale University Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140342003A1 (en) * 2011-12-02 2014-11-20 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US20180117039A1 (en) * 2016-10-27 2018-05-03 Pulmokine, Inc. Combination therapy for treating pulmonary hypertension

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9400411D0 (en) 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
MXPA03000905A (es) 2000-08-02 2003-06-24 Slil Biomedical Corp Compuestos de poliamina ciclicos como tratamiento contra el cancer.
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
WO2009114614A2 (en) 2008-03-11 2009-09-17 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US8883819B2 (en) * 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9895451B2 (en) 2011-12-02 2018-02-20 Yale University Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
US10465042B2 (en) 2011-12-02 2019-11-05 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
WO2013082529A1 (en) 2011-12-02 2013-06-06 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US20210189062A1 (en) 2016-03-01 2021-06-24 Alexion Pharmaceuticals, Inc. Biodegradable activated polymers for therapeutic delivery
WO2017197128A1 (en) 2016-05-11 2017-11-16 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140342003A1 (en) * 2011-12-02 2014-11-20 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US20180117039A1 (en) * 2016-10-27 2018-05-03 Pulmokine, Inc. Combination therapy for treating pulmonary hypertension
CN110087653A (zh) * 2016-10-27 2019-08-02 普尔莫凯恩股份有限公司 用于治疗肺高血压的组合疗法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AGLAIA NTOKOU: "Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension", 《JCI INSIGHT 》, vol. 6, no. 6, 16 February 2021 (2021-02-16), pages 139067 *
ANTONIU等: "Targeting PDGF pathway in pulmonary arterial hypertension", 《EXPERT OPINION ON THERAPEUTIC TARGETS》, vol. 16, no. 11, 31 December 2012 (2012-12-31), pages 1057 - 1059 *
KANAAN RANA 等: "Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease", 《EUROPEAN RESPIRATORY REVIEW》, vol. 26, no. 146, 31 December 2017 (2017-12-31), pages 170061 *
黄群华等: "低氧大鼠肺血管中血小板衍化生长因子α, β受体基因表达的变化", 《中国医学科学院学报》, vol. 19, no. 6, 31 December 1997 (1997-12-31), pages 470 - 472 *

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Publication number Publication date
CA3185957A1 (en) 2022-02-03
WO2022026585A1 (en) 2022-02-03
KR20230047126A (ko) 2023-04-06
EP4188342A1 (en) 2023-06-07
BR112023001379A2 (pt) 2023-02-14
US20220031633A1 (en) 2022-02-03
MX2023000850A (es) 2023-02-15
AU2021315545A1 (en) 2023-02-16
JP2023536119A (ja) 2023-08-23

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