JP2023536119A - 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子 - Google Patents

選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子 Download PDF

Info

Publication number
JP2023536119A
JP2023536119A JP2023505918A JP2023505918A JP2023536119A JP 2023536119 A JP2023536119 A JP 2023536119A JP 2023505918 A JP2023505918 A JP 2023505918A JP 2023505918 A JP2023505918 A JP 2023505918A JP 2023536119 A JP2023536119 A JP 2023536119A
Authority
JP
Japan
Prior art keywords
pdgf
macrophages
formulation
cells
hypoxia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023505918A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023536119A5 (https=
Inventor
ダブリュー． マーク サルツマン，
アグライア ヌトコウ，
ダニエル グライフ，
エイミー カウフマン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of JP2023536119A publication Critical patent/JP2023536119A/ja
Publication of JP2023536119A5 publication Critical patent/JP2023536119A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023505918A 2020-07-28 2021-07-28 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子 Pending JP2023536119A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063057626P 2020-07-28 2020-07-28
US63/057,626 2020-07-28
US17/332,175 2021-05-27
US17/332,175 US20220031633A1 (en) 2020-07-28 2021-05-27 Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
PCT/US2021/043514 WO2022026585A1 (en) 2020-07-28 2021-07-28 Poly(amine-co-ester) polymeric particles for selective pulmonary delivery

Publications (2)

Publication Number Publication Date
JP2023536119A true JP2023536119A (ja) 2023-08-23
JP2023536119A5 JP2023536119A5 (https=) 2024-08-01

Family

ID=80002419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023505918A Pending JP2023536119A (ja) 2020-07-28 2021-07-28 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子

Country Status (10)

Country Link
US (1) US20220031633A1 (https=)
EP (1) EP4188342A1 (https=)
JP (1) JP2023536119A (https=)
KR (1) KR20230047126A (https=)
CN (1) CN116137812A (https=)
AU (1) AU2021315545A1 (https=)
BR (1) BR112023001379A2 (https=)
CA (1) CA3185957A1 (https=)
MX (1) MX2023000850A (https=)
WO (1) WO2022026585A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021293780A1 (en) 2020-06-19 2023-02-02 Yale University Poly(amine-co-ester) polymers with modified end groups and enhanced pulmonary delivery

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140342003A1 (en) * 2011-12-02 2014-11-20 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9400411D0 (en) 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
MXPA03000905A (es) 2000-08-02 2003-06-24 Slil Biomedical Corp Compuestos de poliamina ciclicos como tratamiento contra el cancer.
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
WO2009114614A2 (en) 2008-03-11 2009-09-17 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US8883819B2 (en) * 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
US9895451B2 (en) 2011-12-02 2018-02-20 Yale University Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
US10465042B2 (en) 2011-12-02 2019-11-05 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
WO2013082529A1 (en) 2011-12-02 2013-06-06 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US20210189062A1 (en) 2016-03-01 2021-06-24 Alexion Pharmaceuticals, Inc. Biodegradable activated polymers for therapeutic delivery
WO2017197128A1 (en) 2016-05-11 2017-11-16 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
CA3041679A1 (en) * 2016-10-27 2018-05-03 Lawrence S. ZISMAN Combination therapy for treating pulmonary hypertension

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140342003A1 (en) * 2011-12-02 2014-11-20 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF RESPIRATRY AND CRITICAL CARE MEDICINE, vol. 201, no. 1, JPN6025020630, May 2020 (2020-05-01), pages 2677, ISSN: 0005600020 *
NANO LETT., vol. 20, no. 2, JPN6025020629, February 2020 (2020-02-01), pages 1117 - 1123, ISSN: 0005709732 *

Also Published As

Publication number Publication date
CA3185957A1 (en) 2022-02-03
WO2022026585A1 (en) 2022-02-03
KR20230047126A (ko) 2023-04-06
EP4188342A1 (en) 2023-06-07
BR112023001379A2 (pt) 2023-02-14
US20220031633A1 (en) 2022-02-03
MX2023000850A (es) 2023-02-15
AU2021315545A1 (en) 2023-02-16
CN116137812A (zh) 2023-05-19

Similar Documents

Publication Publication Date Title
CN109476718B (zh) 编码免疫调节多肽的mrna的组合及其用途
AU2018255353B2 (en) P-ethoxy nucleic acids for IGF-1R inhibition
JP2022542389A (ja) 拘束された脂質を含むナノ材料およびその使用
EP3107549B1 (en) Anionic polyplexes for use in the delivery of nucleic acids
CN113197880B (zh) 一种巨噬细胞外泌体膜包被仿生纳米颗粒及其制备方法和应用
WO2014201276A1 (en) Polycation-functionalized nanoporous silicon carrier for systemic delivery of gene silencing agents
JP2021534101A (ja) Ｃｃｒ２及びｃｓｆ１ｒを標的とするためのオリゴヌクレオチド組成物ならびにその使用
US12472199B2 (en) P-ethoxy nucleic acids for IGF-1R inhibition
CN116157444A (zh) 具有改性的端基和增强的肺部递送的聚(胺-共-酯)聚合物
US20250270250A1 (en) Spherical nucleic acids with tailored and active protein coronae
CN116964192B (zh) 工程化迁移体及其制备方法和用途
EP3612159A1 (en) P-ethoxy nucleic acids for stat3 inhibition
WO2016166600A1 (en) Delivery of microrna using mesenchymal stem cell microparticles
JP2023536119A (ja) 選択的肺送達のためのポリ（アミン－ｃｏ－エステル）ポリマー粒子
JP2005176830A (ja) 核酸導入用キャリアー
KR20150129873A (ko) 유전체 약물 전달용 나노입자 및 이의 제조방법
JP7545678B2 (ja) 癌治療剤
WO2025101580A1 (en) Half-antibodies and other antibody fragments for attachment to degradable polymer nanoparticles
EA042663B1 (ru) Р-этокси нуклеиновые кислоты для ингибирования stat3

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240724

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240724

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250522

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250523

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250821

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20251016

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260216

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20260216