BR112023001379A2 - Formulação de distribuição para distribuição seletiva a células imunes pulmonares, tais como macrófagos e monócitos, e método para tratar um indivíduo em necessidade da mesma - Google Patents
Formulação de distribuição para distribuição seletiva a células imunes pulmonares, tais como macrófagos e monócitos, e método para tratar um indivíduo em necessidade da mesmaInfo
- Publication number
- BR112023001379A2 BR112023001379A2 BR112023001379A BR112023001379A BR112023001379A2 BR 112023001379 A2 BR112023001379 A2 BR 112023001379A2 BR 112023001379 A BR112023001379 A BR 112023001379A BR 112023001379 A BR112023001379 A BR 112023001379A BR 112023001379 A2 BR112023001379 A2 BR 112023001379A2
- Authority
- BR
- Brazil
- Prior art keywords
- delivery
- monocytes
- macrophages
- treatment
- need
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000009472 formulation Methods 0.000 title abstract 2
- 210000002865 immune cell Anatomy 0.000 title abstract 2
- 210000004072 lung Anatomy 0.000 title abstract 2
- 210000002540 macrophage Anatomy 0.000 title abstract 2
- 210000001616 monocyte Anatomy 0.000 title abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
FORMULAÇÃO DE DISTRIBUIÇÃO PARA DISTRIBUIÇÃO SELETIVA A CÉLULAS IMUNES PULMONARES, TAIS COMO MACRÓFAGOS E MONÓCITOS, E MÉTODO PARA TRATAR UM INDIVÍDUO EM NECESSIDADE DA MESMA. Polímeros de poli(amina-co-éster), métodos de formação de poliplexos de carga de agente ativo e partículas dos mesmos, e métodos de uso dos mesmos para distribuição de agentes de ácido nucleico com absorção ideal foram desenvolvidos. Exemplos demonstram pesos moleculares críticos em combinação com grupos carboxílicos e/ou hidroxil expostos e métodos de fabricação. Tipicamente, as composições são menos tóxicas, mais eficientes na distribuição do fármaco ou uma combinação das mesmas em comparação com outros reagentes de transfecção de controle. Em algumas modalidades, as composições são adequadas para distribuição in vivo, e podem ser administradas sistemicamente a um sujeito para tratar uma doença ou condição.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063057626P | 2020-07-28 | 2020-07-28 | |
US17/332,175 US20220031633A1 (en) | 2020-07-28 | 2021-05-27 | Poly(amine-co-ester) polymeric particles for selective pulmonary delivery |
PCT/US2021/043514 WO2022026585A1 (en) | 2020-07-28 | 2021-07-28 | Poly(amine-co-ester) polymeric particles for selective pulmonary delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023001379A2 true BR112023001379A2 (pt) | 2023-02-14 |
Family
ID=80002419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023001379A BR112023001379A2 (pt) | 2020-07-28 | 2021-07-28 | Formulação de distribuição para distribuição seletiva a células imunes pulmonares, tais como macrófagos e monócitos, e método para tratar um indivíduo em necessidade da mesma |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220031633A1 (pt) |
EP (1) | EP4188342A1 (pt) |
JP (1) | JP2023536119A (pt) |
KR (1) | KR20230047126A (pt) |
CN (1) | CN116137812A (pt) |
AU (1) | AU2021315545A1 (pt) |
BR (1) | BR112023001379A2 (pt) |
CA (1) | CA3185957A1 (pt) |
MX (1) | MX2023000850A (pt) |
WO (1) | WO2022026585A1 (pt) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
EP1305299A1 (en) | 2000-08-02 | 2003-05-02 | SLIL Biomedical Corporation | Cyclic polyamine compounds for cancer therapy |
JP4095895B2 (ja) | 2000-12-01 | 2008-06-04 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | Rna干渉を媒介する短鎖rna分子 |
US9241898B2 (en) | 2008-03-11 | 2016-01-26 | Yale University | Compositions and methods for controlled delivery of inhibitory ribonucleic acids |
UY34305A (es) * | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
US9272043B2 (en) * | 2011-12-02 | 2016-03-01 | Yale University | Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery |
WO2013082529A1 (en) | 2011-12-02 | 2013-06-06 | Yale University | Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery |
US10465042B2 (en) | 2011-12-02 | 2019-11-05 | Yale University | Poly(amine-co-ester) nanoparticles and methods of use thereof |
US9895451B2 (en) | 2011-12-02 | 2018-02-20 | Yale University | Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof |
WO2017151623A1 (en) | 2016-03-01 | 2017-09-08 | Alexion Pharmaceuticals, Inc. | Biodegradable activated polymers for therapeutic delivery |
WO2017197128A1 (en) | 2016-05-11 | 2017-11-16 | Yale University | Poly(amine-co-ester) nanoparticles and methods of use thereof |
-
2021
- 2021-05-27 US US17/332,175 patent/US20220031633A1/en active Pending
- 2021-07-28 CN CN202180059479.4A patent/CN116137812A/zh active Pending
- 2021-07-28 WO PCT/US2021/043514 patent/WO2022026585A1/en active Application Filing
- 2021-07-28 KR KR1020237005841A patent/KR20230047126A/ko unknown
- 2021-07-28 BR BR112023001379A patent/BR112023001379A2/pt unknown
- 2021-07-28 MX MX2023000850A patent/MX2023000850A/es unknown
- 2021-07-28 AU AU2021315545A patent/AU2021315545A1/en active Pending
- 2021-07-28 CA CA3185957A patent/CA3185957A1/en active Pending
- 2021-07-28 JP JP2023505918A patent/JP2023536119A/ja active Pending
- 2021-07-28 EP EP21758881.3A patent/EP4188342A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4188342A1 (en) | 2023-06-07 |
CA3185957A1 (en) | 2022-02-03 |
US20220031633A1 (en) | 2022-02-03 |
KR20230047126A (ko) | 2023-04-06 |
MX2023000850A (es) | 2023-02-15 |
CN116137812A (zh) | 2023-05-19 |
WO2022026585A1 (en) | 2022-02-03 |
JP2023536119A (ja) | 2023-08-23 |
AU2021315545A1 (en) | 2023-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Mao et al. | Advanced biomaterials for regulating polarization of macrophages in wound healing | |
Li et al. | Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy | |
Wang et al. | pH-responsive calcium alginate hydrogel laden with protamine nanoparticles and hyaluronan oligosaccharide promotes diabetic wound healing by enhancing angiogenesis and antibacterial activity | |
BR112022025855A2 (pt) | Polímero, método de administração de um ou mais agentes de ácido nucleico terapêuticos, de diagnóstico ou profiláticos, ou combinações dos mesmos in vivo | |
Parajó et al. | Hyaluronic acid/Chitosan nanoparticles as delivery vehicles for VEGF and PDGF-BB | |
KR100314488B1 (ko) | 다당류겔조성물 | |
EP2839830B1 (en) | Kits and compositions for treating lower urinary tract disorders | |
Chung et al. | Effects of interpenetration of thermo-sensitive gels by crosslinking of chitosan on nasal delivery of insulin: In vitro characterization and in vivo study | |
Place et al. | Aggrecan-mimetic, glycosaminoglycan-containing nanoparticles for growth factor stabilization and delivery | |
CN101417134A (zh) | 一种透明质酸修饰的新型三元结构非病毒基因传输系统及其应用 | |
Devasani et al. | An overview of in situ gelling systems | |
KR101066763B1 (ko) | 온도 반응성 전달계 | |
Carleton et al. | Methacrylic acid-based hydrogels enhance skeletal muscle regeneration after volumetric muscle loss in mice | |
Ražem et al. | The effects of irradiation on controlled drug delivery/controlled drug release systems | |
Maloney et al. | Nitric oxide-releasing hyaluronic acid as an antibacterial agent for wound therapy | |
Devi et al. | Hydrogel: An updated primer | |
Zhao et al. | Recent developments and current applications of hydrogels in osteoarthritis | |
Tarawneh et al. | Characterization of chlorhexidine-impregnated cellulose-based hydrogel films intended for the treatment of periodontitis | |
Ge et al. | Atmosphere-inspired multilayered nanoarmor with modulable protection and delivery of Interleukin-4 for inflammatory microenvironment modulation | |
JP2020501646A5 (pt) | ||
Zhang et al. | Advanced nanomedicine: redefining therapeutic paradigms for inflammatory bowel disease | |
Ma et al. | Bioinspired Spatiotemporal Management toward RNA Therapies | |
Das Kurmi et al. | Nanocarriers in improved heparin delivery: recent updates | |
Teixeira et al. | Pullulan hydrogels as drug release platforms in biomedicine | |
BR112023001379A2 (pt) | Formulação de distribuição para distribuição seletiva a células imunes pulmonares, tais como macrófagos e monócitos, e método para tratar um indivíduo em necessidade da mesma |