CN1161113C - 氨基硫醇化合物用于制备治疗神经、肾疾病和治疗毒性的药物 - Google Patents

氨基硫醇化合物用于制备治疗神经、肾疾病和治疗毒性的药物 Download PDF

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Publication number
CN1161113C
CN1161113C CNB988135442A CN98813544A CN1161113C CN 1161113 C CN1161113 C CN 1161113C CN B988135442 A CNB988135442 A CN B988135442A CN 98813544 A CN98813544 A CN 98813544A CN 1161113 C CN1161113 C CN 1161113C
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Prior art keywords
amifostine
aminothiol
administration
cisplatin
toxicity
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Expired - Fee Related
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CNB988135442A
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Chinese (zh)
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CN1283994A (zh
Inventor
M��˹�и����
M·斯托格尼夫
D·S·阿尔伯茨
E·H·卡普兰
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MedImmune LLC
University of Arizona
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MedImmune LLC
University of Arizona
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Publication of CN1283994A publication Critical patent/CN1283994A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A—HUMAN NECESSITIES
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
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  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
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  • Pregnancy & Childbirth (AREA)
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  • Endocrinology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB988135442A 1997-12-09 1998-12-09 氨基硫醇化合物用于制备治疗神经、肾疾病和治疗毒性的药物 Expired - Fee Related CN1161113C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/987,550 1997-12-09
US08/987,550 US5994409A (en) 1997-12-09 1997-12-09 Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds

Publications (2)

Publication Number Publication Date
CN1283994A CN1283994A (zh) 2001-02-14
CN1161113C true CN1161113C (zh) 2004-08-11

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CNB988135442A Expired - Fee Related CN1161113C (zh) 1997-12-09 1998-12-09 氨基硫醇化合物用于制备治疗神经、肾疾病和治疗毒性的药物

Country Status (13)

Country Link
US (7) US5994409A (https=)
EP (2) EP1039887B1 (https=)
JP (2) JP2001525359A (https=)
CN (1) CN1161113C (https=)
AT (1) ATE326956T1 (https=)
AU (1) AU739068B2 (https=)
BR (1) BR9813524A (https=)
CA (1) CA2313089C (https=)
DE (1) DE69834658T2 (https=)
DK (1) DK1039887T3 (https=)
ES (1) ES2260857T3 (https=)
PT (1) PT1039887E (https=)
WO (1) WO1999029312A1 (https=)

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CN1283994A (zh) 2001-02-14
EP1537861A3 (en) 2005-06-15
EP1039887A1 (en) 2000-10-04
JP2001525359A (ja) 2001-12-11
DK1039887T3 (da) 2006-09-11
CA2313089C (en) 2010-10-12
EP1039887B1 (en) 2006-05-24
EP1039887A4 (en) 2003-01-15
PT1039887E (pt) 2006-10-31
US20060270636A1 (en) 2006-11-30
EP1537861A2 (en) 2005-06-08
WO1999029312A1 (en) 1999-06-17
ATE326956T1 (de) 2006-06-15
US20060040903A1 (en) 2006-02-23
US7105575B2 (en) 2006-09-12
AU1718499A (en) 1999-06-28
US20020132795A1 (en) 2002-09-19
US20130090312A1 (en) 2013-04-11
JP2006188532A (ja) 2006-07-20
DE69834658D1 (de) 2006-06-29
US6586476B1 (en) 2003-07-01
AU739068B2 (en) 2001-10-04
ES2260857T3 (es) 2006-11-01
US5994409A (en) 1999-11-30
US20110166108A1 (en) 2011-07-07
CA2313089A1 (en) 1999-06-17
BR9813524A (pt) 2002-02-19

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