CN116059343A - 抗rsv单克隆抗体配制品 - Google Patents

抗rsv单克隆抗体配制品 Download PDF

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Publication number
CN116059343A
CN116059343A CN202210988780.XA CN202210988780A CN116059343A CN 116059343 A CN116059343 A CN 116059343A CN 202210988780 A CN202210988780 A CN 202210988780A CN 116059343 A CN116059343 A CN 116059343A
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CN
China
Prior art keywords
formulation
monoclonal antibody
sequence
variable region
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210988780.XA
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English (en)
Chinese (zh)
Inventor
B.罗波
D.哥德堡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MedImmune Ltd
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MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of CN116059343A publication Critical patent/CN116059343A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202210988780.XA 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品 Pending CN116059343A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762465379P 2017-03-01 2017-03-01
US62/465,379 2017-03-01
PCT/US2018/020264 WO2018160722A1 (en) 2017-03-01 2018-02-28 Anti-rsv monoclonal antibody formulation
CN201880014929.6A CN110418803B (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880014929.6A Division CN110418803B (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品

Publications (1)

Publication Number Publication Date
CN116059343A true CN116059343A (zh) 2023-05-05

Family

ID=61903153

Family Applications (3)

Application Number Title Priority Date Filing Date
CN202210988780.XA Pending CN116059343A (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品
CN202410036839.4A Pending CN117982637A (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品
CN201880014929.6A Active CN110418803B (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202410036839.4A Pending CN117982637A (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品
CN201880014929.6A Active CN110418803B (zh) 2017-03-01 2018-02-28 抗rsv单克隆抗体配制品

Country Status (24)

Country Link
US (4) US10774133B2 (https=)
EP (1) EP3589648A4 (https=)
JP (2) JP7046088B2 (https=)
KR (2) KR102668158B1 (https=)
CN (3) CN116059343A (https=)
AR (1) AR111083A1 (https=)
AU (2) AU2018227502B2 (https=)
BR (1) BR112019017755A2 (https=)
CA (1) CA3051864A1 (https=)
CL (1) CL2019002478A1 (https=)
CO (1) CO2019009034A2 (https=)
CR (1) CR20190400A (https=)
EA (1) EA201991701A1 (https=)
EC (1) ECSP19062769A (https=)
GB (1) GB2564175B (https=)
IL (2) IL268202B2 (https=)
MX (1) MX2019010408A (https=)
MY (1) MY206022A (https=)
PH (1) PH12019501979A1 (https=)
SG (1) SG11201906853QA (https=)
TW (2) TWI761453B (https=)
UA (1) UA128450C2 (https=)
WO (1) WO2018160722A1 (https=)
ZA (1) ZA202006797B (https=)

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BR112019018022A2 (pt) * 2017-03-01 2020-06-02 Medimmune Limited Formulações de anticorpos monoclonais
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JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
AU2018263868A1 (en) 2017-05-02 2019-12-12 Merck Sharp & Dohme Llc Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies
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CN120842406A (zh) 2018-10-31 2025-10-28 默沙东有限责任公司 抗人pd-1抗体晶体及其使用方法
CN113316458B (zh) 2018-11-07 2024-08-02 默沙东有限责任公司 抗lag3抗体和抗pd-1抗体的共制剂
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CN115960214A (zh) * 2021-10-12 2023-04-14 中国科学院分子细胞科学卓越创新中心 中和呼吸道合胞病毒的全人抗体的设计及应用
TW202342510A (zh) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
CN119264248A (zh) * 2022-07-22 2025-01-07 北京智仁美博生物科技有限公司 抗呼吸道合胞病毒中和性抗体及其用途
WO2024120516A1 (zh) * 2022-12-08 2024-06-13 南京诺唯赞生物科技股份有限公司 特异性结合rsv的抗体

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Publication number Publication date
CO2019009034A2 (es) 2019-08-30
EP3589648A4 (en) 2020-12-23
EA201991701A1 (ru) 2020-03-04
KR20220020420A (ko) 2022-02-18
US11286294B2 (en) 2022-03-29
AU2018227502A1 (en) 2019-08-15
JP7446356B2 (ja) 2024-03-08
AU2022263564B2 (en) 2025-05-22
JP2020509031A (ja) 2020-03-26
IL312499A (en) 2024-07-01
IL268202B2 (en) 2024-10-01
AU2022263564A1 (en) 2022-12-15
US20230399383A1 (en) 2023-12-14
IL268202B1 (en) 2024-06-01
GB201802974D0 (en) 2018-04-11
SG11201906853QA (en) 2019-09-27
CL2019002478A1 (es) 2020-01-24
CR20190400A (es) 2019-12-03
KR102359181B1 (ko) 2022-02-08
AU2018227502B2 (en) 2022-08-11
US10774133B2 (en) 2020-09-15
BR112019017755A2 (pt) 2020-04-07
EP3589648A1 (en) 2020-01-08
AR111083A1 (es) 2019-05-29
JP2022095697A (ja) 2022-06-28
UA128450C2 (uk) 2024-07-17
ECSP19062769A (es) 2019-09-30
KR102668158B1 (ko) 2024-05-23
US20210317191A1 (en) 2021-10-14
MX2019010408A (es) 2019-12-19
GB2564175B (en) 2021-12-08
ZA202006797B (en) 2023-03-29
TW202228779A (zh) 2022-08-01
TWI911431B (zh) 2026-01-11
US11667698B2 (en) 2023-06-06
US20200339667A1 (en) 2020-10-29
IL268202A (en) 2019-09-26
TWI761453B (zh) 2022-04-21
CA3051864A1 (en) 2018-09-07
TW201840334A (zh) 2018-11-16
MY206022A (en) 2024-11-25
PH12019501979A1 (en) 2020-06-29
WO2018160722A1 (en) 2018-09-07
CN110418803B (zh) 2024-01-19
CN110418803A (zh) 2019-11-05
JP7046088B2 (ja) 2022-04-01
NZ755790A (en) 2024-04-26
KR20190125318A (ko) 2019-11-06
US20180251526A1 (en) 2018-09-06
CN117982637A (zh) 2024-05-07
GB2564175A (en) 2019-01-09

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