CN116058388A - Composition capable of sterilizing and inhibiting viruses and application thereof - Google Patents

Composition capable of sterilizing and inhibiting viruses and application thereof Download PDF

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Publication number
CN116058388A
CN116058388A CN202310050130.5A CN202310050130A CN116058388A CN 116058388 A CN116058388 A CN 116058388A CN 202310050130 A CN202310050130 A CN 202310050130A CN 116058388 A CN116058388 A CN 116058388A
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essential oil
composition
copper powder
mask
viruses
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CN202310050130.5A
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徐宝华
田矿
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Individual
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Individual
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16Heavy metals; Compounds thereof
    • A01N59/20Copper
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/22Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/24Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/28Myrtaceae [Myrtle family], e.g. teatree or clove
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/36Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00Disinfectants; Antimicrobial compounds or mixtures thereof
    • AHUMAN NECESSITIES
    • A41WEARING APPAREL
    • A41DOUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A41D13/1192Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
    • AHUMAN NECESSITIES
    • A41WEARING APPAREL
    • A41DOUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00Materials specially adapted for outerwear
    • A41D31/04Materials specially adapted for outerwear characterised by special function or use
    • A41D31/30Antimicrobial, e.g. antibacterial
    • A41D31/305Antimicrobial, e.g. antibacterial using layered materials
    • DTEXTILES; PAPER
    • D06TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06MTREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M11/00Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
    • D06M11/83Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising with metals; with metal-generating compounds, e.g. metal carbonyls; Reduction of metal compounds on textiles
    • DTEXTILES; PAPER
    • D06TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06MTREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/005Compositions containing perfumes; Compositions containing deodorants
    • DTEXTILES; PAPER
    • D06TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06MTREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/10Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
    • D06M13/144Alcohols; Metal alcoholates
    • D06M13/148Polyalcohols, e.g. glycerol or glucose
    • DTEXTILES; PAPER
    • D06TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06MTREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M16/00Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a composition capable of sterilizing and inhibiting viruses and application thereof, and relates to the technical field of sterilizing preparations, wherein the technical key points are as follows: the composition comprises the following components in percentage by mass: 0.4-0.6% of patchouli essential oil, 0.2-0.3% of lemon essential oil, 0.1-0.2% of geranium essential oil, 0.5-1% of cinnamon essential oil, 0.5-1% of eucalyptus essential oil, 0.2-0.3% of clove essential oil, 0.3-0.5% of peppermint essential oil, 45-55% of water, 8-12% of glycerin, 30-35% of propylene glycol and 3-7% of nano copper powder. The invention adopts the composition of natural plant extraction medicament and nano copper powder for double sterilization, which can instantly kill more than 99 percent of bacteria and viruses, the nano copper powder can kill the residual bacteria and viruses for a long time, and the superfine copper powder copper ions can be naturally metabolized by human body and can not be accumulated in the human body; the composition can be applied to mask sterilization, and the effective shelf life and sterilization time of the mask can reach 2 years.

Description

Composition capable of sterilizing and inhibiting viruses and application thereof
Technical Field
The invention relates to the technical field of sterilization preparations, in particular to a composition capable of sterilizing and inhibiting viruses and application thereof.
Background
The characteristics of viruses are between living and non-living, neither living nor non-living, are in a particulate state, are about one percent of bacteria in size, are above 50 nanometers, and are parasitic to host cell systems for self replication by the mechanism of infection, but cannot grow and replicate independently. In the market, a plurality of multifunctional sterilization modes, such as nano silver, fiber copper, copper oxide, solid alkali and the like, are also newly introduced, but the nano silver, fiber copper, copper oxide, solid alkali filter materials are all single material sterilization and are all physical filtration.
At present, the general mask in the market is generally purely resistant to bacteria and viruses, and cannot effectively play a role when the mask is continuously used for more than 3-4 hours, meanwhile, the current mask cannot kill bacteria and viruses, a certain potential risk exists, and further, people can breathe uncomfortable after wearing the mask for a long time, so that mental state is bad.
In view of this, the present patent is filed.
Disclosure of Invention
The invention aims to solve the problems and provide a composition capable of sterilizing and inhibiting viruses and application thereof, wherein the natural plant extraction reagent and nano copper powder double sterilization mode is adopted to kill viruses and eliminate bacteria, so that the bacteria and viruses can be killed for a long time.
In order to achieve the above purpose, the technical scheme of the invention is as follows: a composition capable of sterilizing and inhibiting viruses comprises the following components in percentage by mass: 0.4-0.6% of patchouli essential oil, 0.2-0.3% of lemon essential oil, 0.1-0.2% of geranium essential oil, 0.5-1% of cinnamon essential oil, 0.5-1% of eucalyptus essential oil, 0.2-0.3% of clove essential oil, 0.3-0.5% of peppermint essential oil, 45-55% of water, 8-12% of glycerin, 30-35% of propylene glycol and 3-7% of nano copper powder.
The patchouli essential oil has the effects of treating depression, calming, inducing estrus, nourishing, astringing, promoting urination, diminishing inflammation and resisting bacteria, and has the greatest characteristics of polymerization, and the wound can promote wound scarring, prevent inflammation and promote cell metabolism. The lemon essential oil can improve circulatory system functions, including promoting blood circulation to reduce blood pressure and stop nose blood; can strengthen immune system, purify body, improve digestive system function, decompose cellulite, and treat dyspepsia and constipation; has the functions of soothing and relieving headache and migraine, and is helpful for treating arthritis and rheumatism by combining acidic substances in the body. It also helps to clean acne, clean greasy skin and hair, and remove dead skin cells. The geranium essential oil contains citronellol, citronellyl formate, terpinene, geranic acid, geraniol, terpineol, citral, menthone and various trace mineral elements, and has the main functions of skin conditioning, and the active ingredients in the geranium extract have strong affinity with natural organic fat; the geranium essential oil has analgesic, astringent, antibacterial, scar extending, and cell defense enhancing effects. The cinnamon essential oil mainly contains components such as cinnamaldehyde and the like, and has various pharmacological activities such as antioxidation, anti-inflammatory, blood sugar reduction, cardiovascular disease resistance, anticancer and the like. Eucalyptus oil has good antibacterial and bactericidal properties and is therefore often used as a raw material for soaps, deodorants, perfumes and other personal hygiene products. Eucalyptus essential oil is diffused in the air, which helps to prevent the spread of bacteria and disinfect the air; can effectively relieve nasal sinus infection, influenza, bronchitis, cold nasal obstruction and other respiratory diseases; it also helps to relieve mental fatigue, muscle pain and debilitation. The oleum Caryophylli has antiinflammatory, antibacterial, and toothache relieving effects. The peppermint essential oil has double effects, can cool when hot and warm the body when cold, can treat cold, and has certain curative effects on dry cough, asthma, bronchitis, pneumonia and phthisis; has effects in relieving flatulence, relieving stomach ache, and heartburn; in addition, it can relieve pain, and is effective for migraine, and can also help to reduce fever.
Preferably, the nano copper powder has a size of-325 mesh and/or a purity of 99.7%.
The nano copper powder has greatly improved surface copper atom activity due to the surface effect caused by small particle size, namely the electron releasing capacity is improved by many times, so that a large amount of copper ions are released, and the released copper ions are positively charged and firmly adsorbed on a cell membrane by virtue of coulomb force when contacting with negatively charged microorganisms; at the same time, copper ions penetrate through cell membranes and enter the bacterial body to form sulfhydryl (-SH) and amino (-NH) groups on proteins in the bacterial body 2 ) And the like, so that the protein of the bacteria is coagulated, the cell membrane synthetase activity of the bacteria is destroyed, the structural change of the bacteria is damaged, the bacteria can continue to react with enzymes, DNA and the like to generate dysfunction, the bacteria die, copper ions can be dissolved out of the bacteria after the bacteria die, and the repeated sterilization effect can be realized. The sterilization principle of the superfine copper powder can not generate drug resistance to bacteria, is superior to antibiotics, and even if a trace amount of copper ions enter human bodies, the copper ions are harmless to the human bodies, can be naturally metabolized by the human bodies and can not be accumulated in the human bodies.
Preferably, the composition comprises the following components in mass ratio: 0.5% of patchouli essential oil, 0.25% of lemon essential oil, 0.1% of geranium essential oil, 0.75% of cinnamon essential oil, 0.75% of eucalyptus essential oil, 0.25% of clove essential oil, 0.4% of peppermint essential oil, 50% of water, 10% of glycerin, 32% of propylene glycol and 5% of nano copper powder.
Preferably, the composition is prepared by a process comprising the steps of:
s1, uniformly mixing patchouli essential oil, lemon essential oil, geranium essential oil, cinnamon essential oil, eucalyptus essential oil, clove essential oil and peppermint essential oil according to a proportion;
s2, uniformly mixing water, glycerol and propylene glycol according to a proportion;
and S3, uniformly mixing and stirring the components obtained in the steps S1 and S2, and then adding the nanometer copper powder and stirring to obtain the composition. In S3, the stirring speed was 800r/min. The composition is prepared in a sterile environment at normal temperature.
Use of a composition for the sterilization and inhibition of viruses, said composition comprising a carrier for use in daily textiles, garments. Garments include hospital doctor and nurse gowns, patient gowns and caretaker clothing, and antibacterial socks and underpants, antibacterial undergarments, clothing, hats, masks, shoes, insoles, gloves. Daily textiles include bed sheets, quilt covers, pillow towels, bath towels and rags.
Preferably, the composition is applied by spraying onto the surface of the carrier and/or by adding it during the carrier preparation process. The composition can be attached to the surface of a carrier in a superfine spray mode or added into a preparation process of carrier fibers, so that the fibers contain an effective amount of the composition, and the composition can be prepared into textiles with the functions of sterilizing and inhibiting viruses and can be repeatedly used, for example, clothes can be repeatedly washed, and the textiles can still sterilize and inhibit viruses after being washed.
Preferably, the composition is sprayed onto the mask surface. Most of masks used in daily life are disposable masks, especially for preventing virus transmission, at present, commonly used disposable masks are used for preventing virus transmission in a filtering mode, the service time of the masks is limited, the masks are required to be replaced for many times every day, and the masks are wasted, if the masks are forgotten to be replaced, the virus transmission cannot be well prevented, so that the masks capable of sterilizing and inhibiting viruses for a long time can solve the problems.
Preferably, the mask comprises three layers, wherein the inner layer is an SSS non-woven fabric skin-friendly layer, the middle layer is an FTFE micro-porous nano membrane filter layer, and the outermost layer is a non-woven fabric layer sprayed with the composition. A combination of multiple filtration layers is used to prevent the transfer of microorganisms, body fluids and particulates, and a bactericidal, antiviral composition is added that kills specific pathogens under specific contact conditions. The composition contains various active ingredients, and alcohols, benzene, phenols and other ingredients contained in essential oil act on viral envelope, so that virus inactivation can be realized, virus cell diffusion can be inhibited, and bacterial virus integrity can be destroyed. When the virus contacts the surface of the mask containing copper, copper ions are released, destroying the viral envelope, causing it to rupture, and the virus is destroyed.
Preferably, the spraying amount of the composition on the mask is 66g/m 2 . The composition can be sprayed on mask to instantly kill more than 99% of bacteria and viruses, and the nanometer copper powder can kill the rest bacteria and viruses for a long time, and can inactivate 99.97% of SARS-COV2 and 99% of human coronavirus (229E) after 1 min.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention adopts a double sterilization mode of natural plant extraction medicament and nano copper powder, more than 99% of bacteria and viruses can be killed instantaneously, the nano copper powder can kill the residual bacteria and viruses for a long time, the total protective effect is 100%, and the superfine copper powder copper ions can be naturally metabolized by human body and cannot be accumulated in the human body.
2. The invention adopts various essential oils with health care effect, and the components such as alcohols, benzene, phenols and the like contained in the essential oils act on the viral envelope, so that the viruses can be inactivated, the intercellular diffusion of the viruses can be inhibited, and the integrity of the bacterial viruses can be damaged.
Detailed Description
In order that those skilled in the art will better understand the present invention, a further detailed description of embodiments of the present invention will be provided below, with the understanding that the present invention is described in some, but not all, embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present invention without making any inventive effort, shall fall within the scope of the present invention.
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other. The present invention will be described in detail with reference to examples.
Example 1
A composition capable of sterilizing and inhibiting viruses is prepared by the following method: uniformly mixing 0.5g of patchouli essential oil, 0.25g of lemon essential oil, 0.1g of geranium essential oil, 0.75g of cinnamon essential oil, 0.75g of eucalyptus essential oil, 0.25g of clove essential oil and 0.4g of peppermint essential oil to obtain phase A; then mixing 53g of water, 10g of glycerol and 32g of propylene glycol uniformly to obtain a phase B; mixing phase A and phase B, stirring, adding 5g nanometer copper powder, and mixing to obtain the final product.
Example 2
A composition capable of sterilizing and inhibiting viruses is prepared by the following method: uniformly mixing 0.4g of patchouli essential oil, 0.3g of lemon essential oil, 0.2g of geranium essential oil, 0.5g of cinnamon essential oil, 0.1g of eucalyptus essential oil, 0.2g of clove essential oil and 0.3g of peppermint essential oil to obtain phase A; then mixing 45g of water, 12g of glycerol and 30g of propylene glycol uniformly to obtain a phase B; mixing phase A and phase B, stirring, adding 4g nanometer copper powder, and mixing to obtain the final product.
Example 3
A composition capable of sterilizing and inhibiting viruses is prepared by the following method: uniformly mixing 0.6g of patchouli essential oil, 0.2g of lemon essential oil, 0.2g of geranium essential oil, 0.1g of cinnamon essential oil, 1g of eucalyptus essential oil, 0.3g of clove essential oil and 0.5g of peppermint essential oil to obtain phase A; then mixing water 55g, glycerin 8g and propylene glycol 35g uniformly to obtain phase B; mixing phase A and phase B, stirring, adding 7g nanometer copper powder, and mixing to obtain the final product.
Example 4
A composition having bactericidal and viral inhibiting functions for textile preparation comprising the steps of: the composition and plastic particles are extruded and granulated by a screw to obtain antibacterial master batches containing a certain amount of superfine copper powder and essential oil, then the antibacterial master batches and common particles are mixed together and melted, and then the antibacterial fiber containing five-thousandth of nanometer copper powder is spun according to the process requirement of melt spinning, so that the antibacterial daily textile containing five-thousandth of copper is obtained.
Example 5
The composition with the functions of sterilizing and inhibiting viruses is sprayed on the mask for sterilizing the mask, the structure of the mask is divided into three layers, the outermost non-woven fabric viral inactivating coating layer of the mask is a microporous nano membrane filter layer of FTFE, and the inner layer is a skin-friendly layer of SSS non-woven fabric. Using 25-40g/m 2 Is a nonwoven fabric of (a) a nonwoven fabric. The unit spray amount on the mask was 66 grams per square meter.The single mask spray composition cured to 2g. The effective quality guarantee and sterilization time is 2 years.
Comparative example 1
A composition capable of sterilizing and inhibiting viruses is prepared by the following method: uniformly mixing 0.5g of patchouli essential oil, 0.25g of lemon essential oil, 0.1g of geranium essential oil, 0.75g of cinnamon essential oil, 0.75g of eucalyptus essential oil, 0.25g of clove essential oil and 0.4g of peppermint essential oil to obtain phase A; then mixing 53g of water, 10g of glycerol and 32g of propylene glycol uniformly to obtain a phase B; mixing phase A and phase B, and stirring to obtain the above composition.
Test 1 inactivated Virus test
The composition was applied to mask materials for sterilization and virus killing tests.
Detection standard: ISO 18184:2019. The test results are shown in Table 1.
TABLE 1 norovirus detection
Figure SMS_1
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Figure SMS_2
As shown in Table 1, the antiviral activity of the virus after 1min incubation of the composition was 98.73%, and the antiviral activity of the virus after 60min incubation was 99.49%.
Test 2 anti-SARS-CoV-2 Virus test
1. Test and consumable:
reagent: DMEM (Thermo Fisher) FBS (Gibco), methylcellulose (Millipore).
2. Test design
Amplification and titer determination of SARS-COV-2 Virus (WIV, genBank: MN 996528.1) P6 Generation SARS-CoV-2 Virus Vero-E6 cells were inoculated at 37C, 5% CO 2 Culturing in incubator for 48 hr, collecting cultured virus supernatant, centrifuging, packaging, and freezing at-80deg.C. Virus titers were determined in Vero-E6 cells using classical plaque assay and the virus diluted to 10 7 PFU/ml。
Sample preparation: cutting the corresponding samples into blocks of 40mm, performing disinfection treatment, and placing each sample into a 6cm dish; the sample is made of nano material textile.
Virus exposure: adding 200ul of virus stock solution into a dish, and naturally and completely dispersing the solution;
treatment and time: incubating the viruses and the materials for 120min, and simultaneously setting an equal amount of virus solution which is not subjected to cloth treatment as a control;
virus elution: after the corresponding treatment time, the sample square is clamped by a gun head and placed into a 50m Ep tube with a cap, 20ml of culture medium is added, the cap is covered, vortex shaking is carried out for 5 times, each time for 5 seconds, and viruses in the sample are eluted:
virus dilution: taking 2ml of virus supernatant as undiluted group (the rest samples are packaged and frozen), adding 200ul undiluted stock solution into 1.8ml of culture medium to obtain 10 -1 Diluting group, further repeating the above operation to obtain 10 -2 ,10 -3 ,10 -4 ,10 -5 Dilution;
plaque assay: cell confluency was observed and the assay was performed only at high confluency. The cell culture medium is replaced by 2% of maintenance medium, diluted virus is added into the maintenance medium, the virus is infected for 2 hours at 37 ℃, the maintenance medium is washed once by the maintenance medium of 2%, 3ml of semisolid culture medium (six-hole plate) can be added, and the culture medium is placed at 37 ℃ for 4d, so that plaque formation can be observed.
The test results are shown in Table 2.
TABLE 2 results of anti-SARS-CoV-2 Virus assay
Processing time Plaque number (PFU) Bacteriostasis rate (%)
1min 3.2*10 3 99.97
Control group 9.7*10 6 ——
As can be seen from Table 2, the novel material treated by the composition provided by the scheme has the activity of resisting SARS-CoV-2 virus, and the inhibition rate of the SARS-CoV-2 virus by incubating the novel material and the virus for 2 hours is up to 99.97%.
Test 3 inactivated New coronavirus test
Experiments with copper powder alone for sterilization show that 4 cm of sterilized nonwoven fabric is placed in a laboratory dish for experiments, and after 10 minutes, the novel coronavirus 10000 is inactivated.
The natural plant extraction medicament is simply used and is not sprayed and transferred to the non-woven fabric of the mask, so that 99.8% of viruses can be inactivated within 1 minute, however, the medicament is transferred to the non-woven fabric and is sprayed and dried, the effect of 5% can be lost, and the virus inactivation rate can only reach 95%.
Therefore, the natural plant extraction medicament and the nanometer copper powder are combined, a sterilizing non-woven fabric with the length of 4 cm is placed in a test dish for experiment, the novel coronavirus 5000000 is inactivated within 1 minute, the efficacy is far superior to that of the pure copper powder, and the loss caused by the high temperature of the natural plant extraction medicament in the production and transfer process is compensated.
The above specific embodiments are provided for illustrative purposes only and are not intended to limit the invention, and modifications, no inventive contribution, will be made to the embodiments by those skilled in the art after having read the present specification, as long as they are within the scope of the patent statutes.

Claims (10)

1. A composition capable of sterilizing and inhibiting viruses, which is characterized by comprising the following components in mass ratio: 0.4-0.6% of patchouli essential oil, 0.2-0.3% of lemon essential oil, 0.1-0.2% of geranium essential oil, 0.5-1% of cinnamon essential oil, 0.5-1% of eucalyptus essential oil, 0.2-0.3% of clove essential oil, 0.3-0.5% of peppermint essential oil, 45-55% of water, 8-12% of glycerin, 30-35% of propylene glycol and 3-7% of nano copper powder.
2. A bactericidal and virucidal composition as in claim 1, wherein the composition includes the following components in mass ratio: 0.5% of patchouli essential oil, 0.25% of lemon essential oil, 0.1% of geranium essential oil, 0.75% of cinnamon essential oil, 0.75% of eucalyptus essential oil, 0.25% of clove essential oil, 0.4% of peppermint essential oil, 50% of water, 10% of glycerin, 32% of propylene glycol and 5% of nano copper powder.
3. A bactericidal and virally-inhibiting composition according to claim 2, wherein the nano-copper powder is-325 mesh in size and/or the nano-copper powder is 99.7% pure.
4. A bactericidal and virucidal composition as in claim 2, wherein the composition is prepared by a process comprising the steps of:
s1, uniformly mixing patchouli essential oil, lemon essential oil, geranium essential oil, cinnamon essential oil, eucalyptus essential oil, clove essential oil and peppermint essential oil according to a proportion;
s2, uniformly mixing water, glycerol and propylene glycol according to a proportion;
and S3, uniformly mixing and stirring the mixed solution obtained in the step S1 and the step S2, and then adding the nanometer copper powder and stirring to obtain the composition.
5. A composition for sterilizing and inhibiting viruses as claimed in claim 4 wherein in S3, the stirring speed is 800r/min.
6. Use of a composition according to any one of claims 1 to 5, wherein: the carrier for applying the composition comprises underwear, clothes, hat, mask, insole, glove, bed sheet, quilt cover, pillow towel, bath towel, and rag.
7. Use of a composition according to claim 6, wherein the composition is sprayable onto the surface of a carrier and/or is added during the carrier preparation process.
8. The use of the composition of claim 6, wherein the composition is sprayed onto the surface of a mask.
9. The use of the composition of claim 8, wherein the mask comprises three layers, an inner layer is an SSS nonwoven layer, an intermediate layer is a FTFE microporous nanomembrane filtration layer, and an outermost layer is a nonwoven layer of spray composition.
10. The use of the composition according to claim 9, wherein the composition is sprayed onto the outermost layer of the mask in an amount of 66g/m 2
CN202310050130.5A 2023-02-01 2023-02-01 Composition capable of sterilizing and inhibiting viruses and application thereof Pending CN116058388A (en)

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CN112616861A (en) * 2020-12-14 2021-04-09 杭州象外环保科技有限公司 Novel natural plant extract essential oil coronavirus disinfectant and application thereof
KR102305665B1 (en) * 2020-08-10 2021-09-28 (주)네이처페어리 Antiviral or antibacterial compositions comprising Dendropanax morbiferus
CN113767938A (en) * 2021-08-30 2021-12-10 柳州市中医医院(柳州市壮医医院) Zhuang nationality medicine air disinfectant
CN114246925A (en) * 2020-09-22 2022-03-29 香港科技大学 Traditional Chinese medicine essential oil and application thereof
CN114916564A (en) * 2022-05-27 2022-08-19 成都中医药大学附属医院 Essential oil composition for inhibiting novel coronavirus
CN114931250A (en) * 2022-04-08 2022-08-23 浙江格林沃德非织造布有限公司 Antiviral mask structure containing nano-copper and preparation process thereof
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008153077A1 (en) * 2007-06-12 2008-12-18 Hiroshima University Anti-norovirus agent, and composition comprising the same
CN111407859A (en) * 2020-04-29 2020-07-14 北京天然风尚健康科技有限公司 Preparation method and application of armor essential oil composition with antibacterial and antiviral effects
KR102305665B1 (en) * 2020-08-10 2021-09-28 (주)네이처페어리 Antiviral or antibacterial compositions comprising Dendropanax morbiferus
CN114246925A (en) * 2020-09-22 2022-03-29 香港科技大学 Traditional Chinese medicine essential oil and application thereof
CN112616861A (en) * 2020-12-14 2021-04-09 杭州象外环保科技有限公司 Novel natural plant extract essential oil coronavirus disinfectant and application thereof
CN115363058A (en) * 2021-07-18 2022-11-22 杭州绿键生物科技有限公司 Novel disinfectant for effectively inactivating novel coronavirus
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CN114931250A (en) * 2022-04-08 2022-08-23 浙江格林沃德非织造布有限公司 Antiviral mask structure containing nano-copper and preparation process thereof
CN114916564A (en) * 2022-05-27 2022-08-19 成都中医药大学附属医院 Essential oil composition for inhibiting novel coronavirus

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