CN110934809A - Antibacterial and anti-inflammatory child skin-care talcum powder and preparation method thereof - Google Patents
Antibacterial and anti-inflammatory child skin-care talcum powder and preparation method thereof Download PDFInfo
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- CN110934809A CN110934809A CN201911239849.3A CN201911239849A CN110934809A CN 110934809 A CN110934809 A CN 110934809A CN 201911239849 A CN201911239849 A CN 201911239849A CN 110934809 A CN110934809 A CN 110934809A
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 33
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 31
- 239000000843 powder Substances 0.000 claims abstract description 47
- 238000001035 drying Methods 0.000 claims abstract description 32
- 238000003756 stirring Methods 0.000 claims abstract description 26
- 238000013268 sustained release Methods 0.000 claims abstract description 26
- 239000012730 sustained-release form Substances 0.000 claims abstract description 26
- 239000002775 capsule Substances 0.000 claims abstract description 25
- 239000000419 plant extract Substances 0.000 claims abstract description 25
- 229920000881 Modified starch Polymers 0.000 claims abstract description 23
- 238000007873 sieving Methods 0.000 claims abstract description 21
- 229920002261 Corn starch Polymers 0.000 claims abstract description 20
- 239000008120 corn starch Substances 0.000 claims abstract description 20
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 45
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 28
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 24
- 229920000642 polymer Polymers 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 238000006011 modification reaction Methods 0.000 claims description 11
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims description 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 10
- YIOJGTBNHQAVBO-UHFFFAOYSA-N dimethyl-bis(prop-2-enyl)azanium Chemical compound C=CC[N+](C)(C)CC=C YIOJGTBNHQAVBO-UHFFFAOYSA-N 0.000 claims description 10
- 230000033444 hydroxylation Effects 0.000 claims description 10
- 238000005805 hydroxylation reaction Methods 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 239000011787 zinc oxide Substances 0.000 claims description 10
- 241000196324 Embryophyta Species 0.000 claims description 9
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 7
- 239000001569 carbon dioxide Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 125000000524 functional group Chemical group 0.000 claims description 6
- 230000032683 aging Effects 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
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- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
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- 238000010008 shearing Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 239000011573 trace mineral Substances 0.000 claims description 5
- 235000013619 trace mineral Nutrition 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 241000737253 Lygodium japonicum Species 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- NPSSWQJHYLDCNV-UHFFFAOYSA-N prop-2-enoic acid;hydrochloride Chemical compound Cl.OC(=O)C=C NPSSWQJHYLDCNV-UHFFFAOYSA-N 0.000 claims description 2
- 241000205585 Aquilegia canadensis Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 10
- 206010061218 Inflammation Diseases 0.000 abstract description 8
- 230000004054 inflammatory process Effects 0.000 abstract description 8
- 239000011148 porous material Substances 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 4
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- 238000012986 modification Methods 0.000 abstract description 2
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- 230000000052 comparative effect Effects 0.000 description 13
- 241001570521 Lonicera periclymenum Species 0.000 description 7
- 210000004243 sweat Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 4
- -1 2-hydroxymethyl ethyl Chemical group 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000737263 Lygodium Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
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- 238000007334 copolymerization reaction Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 201000004169 miliaria rubra Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
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- 241000218691 Cupressaceae Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
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- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 244000007853 Sarothamnus scoparius Species 0.000 description 1
- 229910018557 Si O Inorganic materials 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- OBNDGIHQAIXEAO-UHFFFAOYSA-N [O].[Si] Chemical group [O].[Si] OBNDGIHQAIXEAO-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
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- 238000005054 agglomeration Methods 0.000 description 1
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- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000955 neuroendocrine Effects 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
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- 150000002989 phenols Chemical class 0.000 description 1
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- 239000000047 product Substances 0.000 description 1
- 239000009910 sargent gloryvine Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Inorganic materials [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
- A61K8/9749—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of antibacterial and anti-inflammatory children skin-care talcum powder, which comprises the steps of performing modification treatment on cage-type silsesquioxane of corn starch and pearl powder, preparing a functional sustained-release capsule, uniformly stirring and mixing, and sieving by adopting a 50-100-mesh sieve to prepare the antibacterial and anti-inflammatory children skin-care talcum powder. The talcum powder disclosed by the invention has the effects of smoothing and drying skin and not blocking pores by compounding the cage-type silsesquioxane modified corn starch and the modified pearl powder, and effectively prevents the skin of an infant from generating miliaria; the active ingredients of the plant extracts in the talcum powder are slowly released under the action of the functional sustained-release capsule, so that the skin of the infant can continuously and durably play the roles of resisting bacteria and diminishing inflammation.
Description
Technical Field
The invention relates to the technical field of talcum powder, and particularly relates to antibacterial and anti-inflammatory children skin-care talcum powder and a preparation method thereof.
Background
The moisture content of skin of infants is large, the distribution of blood vessels on the surface of the skin is also large, the activity is large, and the metabolism is vigorous, so the moisture evaporated by the skin is also large. The secretion of sweat gland is regulated by vegetative nerve, so that the neuroendocrine regulating function of baby is relatively poor, and the inhibition function of cerebral cortex to vegetative nerve is poor, so that the self-regulation ability of baby to cold and hot is poor. Even when sleeping at night, the baby can sweat easily.
Except timely changing the sweat clothes and avoiding contacting with irritant bath products, in order to protect the skin of the baby from dryness and cleanness, the occurrence of skin diseases such as miliaria, red butt and the like is avoided, and a mother can select the baby talcum powder for the baby with much sweat to nurse the skin.
The talcum powder prepared by the traditional method adopts raw materials which are not modified, so that the powder is easy to agglomerate after absorbing sweat in use, cannot keep dry and can be stuck on the skin of a baby to stimulate the skin; meanwhile, the agglomerated talcum powder is easy to cause skin allergy and loss due to clothes friction, and secondary damage is brought to the skin of the baby. In addition, the traditional talcum powder is easy to cause sweat accumulation of the baby, block skin pores of the baby and stimulate the delicate skin of the baby, so that prickly heat or bacteria are bred or other skin diseases such as inflammation occur, the baby feels uncomfortable, and the body health of the baby is influenced.
Disclosure of Invention
In view of the defects of the prior art, the invention provides the antibacterial and anti-inflammatory children skin-care talcum powder, which aims to solve the problems that the skin of an infant is itchy, prickly heat, bacteria are bred and inflammation is caused by the fact that the existing talcum powder is easy to agglomerate and block skin pores, and good smooth, comfortable, safe and healthy experience is brought to the skin of the infant.
In order to achieve the above purposes, the technical scheme adopted by the invention is as follows:
a preparation method of an antibacterial and anti-inflammatory children skin-care talcum powder comprises the following steps:
preparation of S1 modified corn starch: carrying out hydroxylation treatment on corn starch, dispersing the corn starch in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 1-5 hours in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by using a 30-100-mesh sieve to obtain the modified corn starch; the grafting rate of the corn starch is 1-10%;
s2 preparation of modified pearl powder: carrying out hydroxylation treatment on pearl powder, dispersing the pearl powder in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 1-5 h in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by using a 30-100-mesh sieve to obtain the modified pearl powder; the grafting rate of the pearl powder is 1-10%;
s3 preparation of functional sustained-release capsules: dissolving dimethyl diallyl ammonium chloride-acrylic acid copolymer in dichloromethane to obtain a continuous phase solution, dissolving octahydroxy polyhedral oligomeric silsesquioxane, ethyl acrylate and derivative polymers thereof in dichloromethane, stirring for dissolving, and adding zinc oxide solid matter to obtain a dispersed phase; in the process of adding the dispersed phase into the continuous phase solution, dropwise adding a plant extract solution, and after dropwise adding is finished, carrying out high-speed shearing and low-speed stirring until dichloromethane is completely volatilized; finally, aging, washing and drying at normal temperature to obtain the functional sustained-release capsule;
preparation of S4 talcum powder: and (4) uniformly stirring and mixing the modified corn starch obtained in the step S1, the modified pearl powder obtained in the step S2 and the functional sustained-release capsule obtained in the step S3, and sieving by adopting a 50-100-mesh sieve to obtain the antibacterial and anti-inflammatory children skin-care talcum powder.
Preferably, the ethyl acrylate and the derivative polymer thereof are polymers obtained by copolymerization or homopolymerization of at least one of ethyl acrylate, 2-hydroxymethyl ethyl acrylate, 3-dimethyl ethyl acrylate, 2- (trimethylsilyl methyl) ethyl acrylate and ethyl methacrylate.
The functional sustained-release capsule is a composite material of cage-type silsesquioxane and an ethyl acrylate polymer, and the composite material enables a plant extract solution to have good dispersing and anti-adhesion effects; the active ingredients of the plant extracts in the talcum powder can be slowly released under the action of the functional sustained-release capsule, so that the skin of the infant can continuously and durably play the roles of resisting bacteria and diminishing inflammation.
Preferably, the cage type silsesquioxane has a monofunctional POSS structure with the general formula of (RSiO)3/2) n, the single reactive group R is carboxyl and derivatives containing carboxyl functional groups.
Polyhedral oligomeric silsesquioxanes (POSS) are inorganic cores composed of silicon-oxygen skeletons alternately connected by Si-O, and have a general formula (RSiO)3/2) n, wherein R is a group to which eight apical Si atoms are attached; monofunctional POSS means that only one of the eight apex groups is a reactive group and the remaining seven are inert groups.
Through the graft modification reaction of the POSS with the corn starch and the pearl powder, on one hand, the moisture absorption performance of the talcum powder can be improved due to the unique effect of the cage-shaped structure, the skin is ensured to be dry and smooth, and the skin pore can not be blocked due to the cage-shaped structure of the inorganic core while sweat is absorbed deeply; on the other hand, the agglomeration phenomenon of the corn starch and the pearl powder can be effectively prevented due to the action of the inert functional group connected with the vertex angle of the inorganic core; the cage-type silsesquioxane has a stable organic-inorganic hybrid structure, organic matters cannot be volatilized through the modified corn starch and the modified pearl powder, the organic matters cannot permeate into skin, and the obtained talcum powder has good effects of environmental protection, safety, smoothness and no adhesion; is very suitable for the use requirements of infants.
Preferably, in step S3, the plant extract solution is prepared by: cleaning plant raw materials, crushing, sieving, sterilizing, drying, placing in a high-pressure reaction kettle, introducing supercritical carbon dioxide fluid as an extraction solvent to effectively extract active ingredients and trace elements contained in the plants, and adding deionized water to prepare a plant extract solution with the mass concentration of 5-25 wt%.
Preferably, the plant material is at least one selected from the group consisting of broom cypress fruit, honeysuckle stem, argyi leaf and lygodium stem.
Kochia scoparia belongs to Chenopodiaceae, has effects of clearing heat and relieving itching, etc., and its tender stem contains microelements.
Honeysuckle stem is also known as honeysuckle stem, and belongs to the family of Caprifoliaceae. Mainly contains chlorogenic acid and flavonoid loniceraside. Has the effects of clearing away heat and toxic materials, dispelling pathogenic wind, and dredging collaterals. Wherein luteolin has antiinflammatory effect.
Folium Artemisiae Argyi belongs to Compositae, and has effects of eliminating pathogenic factors and expelling parasites, and also has antipruritic and antiinflammatory effects. Folium Artemisiae Argyi can inhibit over ten gram-positive aerophiles, and also has inhibitory effect on dermatophytosis fungi.
Lygodium japonicum is a perennial climbing fern, and is a traditional Chinese medicine. The vine contains saccharide, flavonoid glycoside, amino acid and phenols, and the leaf contains flavonoids. Relieve heat-toxicity, diminish inflammation, alleviate pain, treat damp-heat swelling.
Preferably, the supercritical carbon dioxide has a temperature of 34 ℃ and a pressure of 75 atm.
Preferably, in step S3, the mass of the dimethyldiallylammonium chloride-acrylic acid copolymer accounts for 1-5 wt% of the continuous phase solution.
Preferably, in step S3, the octahydroxy cage-type silsesquioxane, the ethyl acrylate and the derived polymer thereof are added in an amount of 1: 6-8, wherein the total mass of the octahydroxyl cage-type silsesquioxane, the ethyl acrylate and the derivative polymer thereof accounts for 10-20 wt% of the dispersed phase, and the mass of the zinc oxide accounts for 3-12 wt% of the dispersed phase.
Preferably, in step S3, the mass ratio of the continuous phase solution, the dispersed phase and the plant extract solution is 10 to 20: 10-20: 1 to 5.
Preferably, the mass ratio of the modified corn starch to the modified pearl powder to the functional sustained-release capsule is 30-70: 15-25: 1 to 5.
Correspondingly, the children skin-care talcum powder is prepared according to the preparation method of the children skin-care talcum powder with the antibacterial and anti-inflammatory effects.
The invention has the beneficial effects that:
the prepared talcum powder is compounded by the cage-type silsesquioxane modified corn starch and the modified pearl powder, so that the effects of smoothing and drying skin and not blocking pores are achieved, and miliaria on the skin of an infant is effectively prevented; the active ingredients of the plant extracts in the talcum powder are slowly released under the action of the functional sustained-release agent, and other ingredients in the talcum powder are compounded, so that the antibacterial and anti-inflammatory effects of the skin of the infants are continuously and long-term achieved, and the smooth, comfortable, safe and healthy good experience is brought to the skin of the infants.
Detailed Description
The following description is presented to disclose the invention so as to enable any person skilled in the art to practice the invention. The preferred embodiments in the following description are given by way of example only, and other obvious variations will occur to those skilled in the art.
Example 1
The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder comprises the following steps:
preparation of S1 modified corn starch: carrying out hydroxylation treatment on corn starch, dispersing the corn starch in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 3 hours in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by a 50-mesh sieve to obtain the modified corn starch; the grafting rate of the corn starch is 5%;
s2 preparation of modified pearl powder: carrying out hydroxylation treatment on pearl powder, dispersing the pearl powder in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 3 hours in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by a 50-mesh sieve to obtain the modified pearl powder; the grafting rate of the pearl powder is 5 percent;
s3 preparation of functional sustained-release capsules: dissolving dimethyl diallyl ammonium chloride-acrylic acid copolymer in dichloromethane to obtain a continuous phase solution, dissolving octahydroxy polyhedral oligomeric silsesquioxane, ethyl acrylate and derivative polymers thereof in dichloromethane, stirring for dissolving, and adding zinc oxide solid matter to obtain a dispersed phase; in the process of adding the dispersed phase into the continuous phase solution, dropwise adding a plant extract solution, and after dropwise adding is finished, carrying out high-speed shearing and low-speed stirring until dichloromethane is completely volatilized; finally, aging, washing and drying at normal temperature to obtain the functional sustained-release capsule; the mass of the dimethyl diallyl ammonium chloride-acrylic acid copolymer accounts for 3wt% of the continuous phase solution; the addition amount of the octahydroxyl cage type silsesquioxane, the ethyl acrylate and the derivative polymer thereof is that the molar ratio of the octahydroxyl cage type silsesquioxane to the ethyl acrylate is 1: 8, the total mass of the octahydroxyl cage-type silsesquioxane, the ethyl acrylate and the derivative polymer thereof accounts for 15wt% of the dispersed phase, and the mass of the zinc oxide accounts for 8wt% of the dispersed phase; the mass ratio of the continuous phase solution to the dispersed phase to the plant extract solution is 15: 15: 2;
preparation of S4 talcum powder: and (4) uniformly stirring and mixing the modified corn starch obtained in the step S1, the modified pearl powder obtained in the step S2 and the functional sustained-release capsule obtained in the step S3, and sieving by using a 70-mesh sieve to obtain the antibacterial and anti-inflammatory children skin-care talcum powder. The mass ratio of the modified corn starch, the modified pearl powder and the functional sustained-release capsule is 50: 20: 3.
the ethyl acrylate and the derivative polymer thereof are polymers obtained by copolymerization and the like by using 2-hydroxymethyl ethyl acrylate and ethyl methacrylate as monomers.
The cage type silsesquioxane is a monofunctional POSS structure and has a general formula of (RSiO)3/2) n, the single reactive group R is carboxyl and derivatives containing carboxyl functional groups.
In step S3, the plant extract solution is prepared by: mixing the components in a mass ratio of 1: 2, crushing, sieving, sterilizing and drying the fructus kochiae and the honeysuckle vines, putting the mixture into a high-pressure reaction kettle, introducing supercritical carbon dioxide fluid serving as an extraction solvent to effectively extract active ingredients and trace elements contained in the plants, and adding deionized water to prepare a plant extract solution with the mass concentration of 15 wt%.
Example 2
The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder comprises the following steps:
preparation of S1 modified corn starch: carrying out hydroxylation treatment on corn starch, dispersing the corn starch in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 1h in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by a 30-mesh sieve to obtain the modified corn starch; the grafting rate of the corn starch is 1%;
s2 preparation of modified pearl powder: carrying out hydroxylation treatment on pearl powder, dispersing the pearl powder in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 1h in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by a 30-mesh sieve to obtain the modified pearl powder; the grafting rate of the pearl powder is 1 percent;
s3 preparation of functional sustained-release capsules: dissolving dimethyl diallyl ammonium chloride-acrylic acid copolymer in dichloromethane to obtain a continuous phase solution, dissolving octahydroxy polyhedral oligomeric silsesquioxane, ethyl acrylate and derivative polymers thereof in dichloromethane, stirring for dissolving, and adding zinc oxide solid matter to obtain a dispersed phase; in the process of adding the dispersed phase into the continuous phase solution, dropwise adding a plant extract solution, and after dropwise adding is finished, carrying out high-speed shearing and low-speed stirring until dichloromethane is completely volatilized; finally, aging, washing and drying at normal temperature to obtain the functional sustained-release capsule; the mass of the dimethyl diallyl ammonium chloride-acrylic acid copolymer accounts for 1wt% of the continuous phase solution; the addition amount of the octahydroxyl cage type silsesquioxane, the ethyl acrylate and the derivative polymer thereof is that the molar ratio of the octahydroxyl cage type silsesquioxane to the ethyl acrylate is 1: 6, the total mass of the octahydroxyl cage-type silsesquioxane, the ethyl acrylate and the derivative polymer thereof accounts for 10wt% of the dispersed phase, and the mass of the zinc oxide accounts for 3wt% of the dispersed phase; the mass ratio of the continuous phase solution to the dispersed phase to the plant extract solution is 10: 10: 1;
preparation of S4 talcum powder: and (4) uniformly stirring and mixing the modified corn starch obtained in the step S1, the modified pearl powder obtained in the step S2 and the functional sustained-release capsule obtained in the step S3, and sieving by using a 50-mesh sieve to obtain the antibacterial and anti-inflammatory children skin-care talcum powder. The mass ratio of the modified corn starch, the modified pearl powder and the functional sustained-release capsule is 30: 15: 1.
the ethyl acrylate and the derivative polymer thereof are polymers obtained by homopolymerizing 3, 3-ethyl dimethacrylate serving as a monomer.
The cage type silsesquioxane is a monofunctional POSS structure and has a general formula of (RSiO)3/2) n, the single reactive group R is carboxyl and derivatives containing carboxyl functional groups.
In step S3, the plant extract solution is prepared by: mixing the components in a mass ratio of 1: 1: 3, crushing, sieving, sterilizing and drying the honeysuckle vine, the folium artemisiae argyi or the lygodium japonicum, putting the crushed, sieved, sterilized and dried honeysuckle vine and the folium artemisiae argyi or the lygodium japonicum into a high-pressure reaction kettle, introducing supercritical carbon dioxide fluid as an extraction solvent to effectively extract active ingredients and trace elements contained in the plants, and adding deionized water to prepare a plant extract solution with the mass concentration of 5 wt%.
Example 3
The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder comprises the following steps:
preparation of S1 modified corn starch: carrying out hydroxylation treatment on corn starch, dispersing the corn starch in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 5 hours in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by using a 100-mesh sieve to obtain the modified corn starch; the grafting rate of the corn starch is 10 percent;
s2 preparation of modified pearl powder: carrying out hydroxylation treatment on pearl powder, dispersing the pearl powder in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 5 hours in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by using a 100-mesh sieve to obtain the modified pearl powder; the grafting rate of the pearl powder is 10 percent;
s3 preparation of functional sustained-release capsules: dissolving dimethyl diallyl ammonium chloride-acrylic acid copolymer in dichloromethane to obtain a continuous phase solution, dissolving octahydroxy polyhedral oligomeric silsesquioxane, ethyl acrylate and derivative polymers thereof in dichloromethane, stirring for dissolving, and adding zinc oxide solid matter to obtain a dispersed phase; in the process of adding the dispersed phase into the continuous phase solution, dropwise adding a plant extract solution, and after dropwise adding is finished, carrying out high-speed shearing and low-speed stirring until dichloromethane is completely volatilized; finally, aging, washing and drying at normal temperature to obtain the functional sustained-release capsule; the mass of the dimethyl diallyl ammonium chloride-acrylic acid copolymer accounts for 5wt% of the continuous phase solution; the addition amount of the octahydroxyl cage type silsesquioxane, the ethyl acrylate and the derivative polymer thereof is that the molar ratio of the octahydroxyl cage type silsesquioxane to the ethyl acrylate is 1: 8, the sum of the mass of the octahydroxyl cage-type silsesquioxane, the mass of the ethyl acrylate and the derivative polymer thereof accounts for 20wt% of the dispersed phase, and the mass of the zinc oxide accounts for 12wt% of the dispersed phase; the mass ratio of the continuous phase solution to the dispersed phase to the plant extract solution is 20: 20: 5;
preparation of S4 talcum powder: and (4) uniformly stirring and mixing the modified corn starch obtained in the step S1, the modified pearl powder obtained in the step S2 and the functional sustained-release capsule obtained in the step S3, and sieving by using a 100-mesh sieve to obtain the antibacterial and anti-inflammatory children skin-care talcum powder. The mass ratio of the modified corn starch, the modified pearl powder and the functional sustained-release capsule is 70: 25: 5.
the ethyl acrylate and the derivative polymer thereof are polymers obtained by homopolymerization and the like by taking ethyl methacrylate as a monomer.
The cage type silsesquioxane is a monofunctional POSS structure and has a general formula of (RSiO)3/2) n, the single reactive group R is carboxyl and derivatives containing carboxyl functional groups.
In step S3, the plant extract solution is prepared by: mixing the following components in parts by weight: 1: 1: 1, cleaning fructus kochiae, honeysuckle stem, folium artemisiae argyi or lygodium sargentgloryvine, crushing, sieving, sterilizing, drying, placing in a high-pressure reaction kettle, introducing supercritical carbon dioxide fluid as an extraction solvent to effectively extract active ingredients and trace elements contained in the plants, and adding deionized water to prepare a plant extract solution with the mass concentration of 25 wt%.
Comparative example 1
The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder of the comparative example is basically similar to that of example 1, and the main difference is that the corn starch in the talcum powder raw material is unmodified corn starch.
Comparative example 2
The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder of the comparative example is basically similar to that of example 1, and the main difference is that the powder for delivering pollen in the talcum powder raw material is unmodified pearl powder.
Comparative example 3
The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder of the comparative example is basically similar to that of example 1, and the main difference is that the plant extracts in the talcum powder raw materials are not prepared into functional sustained-release capsules and are added into the talcum powder, but are directly added.
The toilet powder prepared in the examples 1-3 and the comparative examples 1-3 is subjected to performance tests, and the performance results are shown in the following table 1:
and (3) caking condition test: soaking the rat skin in water, taking out, leveling and airing to enable the water content of the rat skin to reach 10%, cutting the rat skin into 6 blocks, respectively coating the talcum powder prepared in the examples 1-3 and the comparative examples 1-3 on the rat skin, and observing the caking condition of the talcum powder on the rat skin after 24 hours.
And (3) testing antibacterial performance: respectively culturing Escherichia coli and Staphylococcus aureus in olive oil agar medium at 37 deg.C for 24 hr to reach concentration of 2 mg/ml; then, 6 healthy white rabbits with the weight of 20-25kg are selected, hairs on two sides of the spine of the back of the white rabbits are cut off 24 hours before the test, the left side and the right side of the hair removing range are about 3cm x 3cm respectively, and the next day, the talcum powder prepared in the examples 1-3 and the comparative examples 1-3 is uniformly smeared on the surface of the hair removed skin; and finally, dropwise adding the cultured escherichia coli and staphylococcus aureus to the surface of the skin, and observing the bacteriostasis rate of the surface of the skin.
And (3) testing the anti-inflammatory performance: the talcum powder prepared in the examples 1-3 and the comparative examples 1-3 is uniformly smeared on the surface of the skin with inflammation of the rabbit, and the fading days of the inflammation and the irritation effect of the skin are observed.
TABLE 1
| Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Water absorption | High strength | High strength | High strength | High strength | High strength | High strength |
| Caking behavior | Is free of | Is free of | Is free of | Severe severity of disease | Severe severity of disease | Is free of |
| The bacteriostatic rate of Escherichia coli, percent | 99.5 | 99.3 | 99.4 | 82.2 | 81.3 | 85.4 |
| Staphylococcus aureus inhibition rate% | 99.4 | 99.3 | 99.1 | 81.5 | 82.1 | 86.2 |
| Days of resolution of inflammation | 5 | 5 | 5 | 7 | 7 | 3 |
| Irritation property | Is free of | Is free of | Is free of | Is free of | Is free of | Light and slight |
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed.
Claims (10)
1. The preparation method of the antibacterial and anti-inflammatory child skin-care talcum powder is characterized by comprising the following steps of:
preparation of S1 modified corn starch: carrying out hydroxylation treatment on corn starch, dispersing the corn starch in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 1-5 hours in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by using a 30-100-mesh sieve to obtain the modified corn starch; the grafting rate of the corn starch is 1-10%;
s2 preparation of modified pearl powder: carrying out hydroxylation treatment on pearl powder, dispersing the pearl powder in an ethanol solution, uniformly stirring, adding cage-type silsesquioxane for carrying out graft modification reaction, reacting for 1-5 h in a water bath at 30 ℃, and then carrying out centrifugal separation, drying at 60 ℃ in a drying oven and sieving by using a 30-100-mesh sieve to obtain the modified pearl powder; the grafting rate of the pearl powder is 1-10%;
s3 preparation of functional sustained-release capsules: dissolving dimethyl diallyl ammonium chloride-acrylic acid copolymer in dichloromethane to obtain a continuous phase solution, dissolving octahydroxy polyhedral oligomeric silsesquioxane, ethyl acrylate and derivative polymers thereof in dichloromethane, stirring for dissolving, and adding zinc oxide solid matter to obtain a dispersed phase; in the process of adding the dispersed phase into the continuous phase solution, dropwise adding a plant extract solution, and after dropwise adding is finished, carrying out high-speed shearing and low-speed stirring until dichloromethane is completely volatilized; finally, aging, washing and drying at normal temperature to obtain the functional sustained-release capsule;
preparation of S4 talcum powder: and (4) uniformly stirring and mixing the modified corn starch obtained in the step S1, the modified pearl powder obtained in the step S2 and the functional sustained-release capsule obtained in the step S3, and sieving by adopting a 50-100-mesh sieve to obtain the antibacterial and anti-inflammatory children skin-care talcum powder.
2. The method for preparing the antibacterial and anti-inflammatory children skin-care talcum powder as claimed in claim 1, wherein the cage-type silsesquioxane has a mono-functional group POSS structure with a general formula of (RSiO)3/2) n, the single reactive group R is carboxyl and derivatives containing carboxyl functional groups.
3. The method for preparing the antibacterial and anti-inflammatory children skin care talcum powder according to claim 1, wherein in the step S3, the plant extract solution is prepared by the following steps: cleaning plant raw materials, crushing, sieving, sterilizing, drying, placing in a high-pressure reaction kettle, introducing supercritical carbon dioxide fluid as an extraction solvent to effectively extract active ingredients and trace elements contained in the plants, and adding deionized water to prepare a plant extract solution with the mass concentration of 5-25 wt%.
4. The method for preparing the antibacterial and anti-inflammatory children skin-care talcum powder as claimed in claim 3, wherein the plant raw material is at least one of belvedere fruit, honeysuckle stem, argyi leaf or lygodium japonicum stem.
5. The method for preparing antibacterial and anti-inflammatory children skin care talcum powder according to claim 3, wherein the temperature of the supercritical carbon dioxide is 34 ℃ and the pressure is 75 atm.
6. The method for preparing the antibacterial and anti-inflammatory children skin-care talcum powder according to claim 1, wherein in step S3, the mass of the dimethyldiallylammonium chloride-acrylic acid copolymer accounts for 1-5 wt% of the continuous phase solution.
7. The method for preparing antibacterial and anti-inflammatory children' S skin care powder according to claim 1, wherein in step S3, the octahydroxy cage-type silsesquioxane, ethyl acrylate and derived polymers thereof are added in an amount of 1: 6-8, wherein the total mass of the octahydroxyl cage-type silsesquioxane, the ethyl acrylate and the derivative polymer thereof accounts for 10-20 wt% of the dispersed phase, and the mass of the zinc oxide accounts for 3-12 wt% of the dispersed phase.
8. The preparation method of the antibacterial and anti-inflammatory children skin care talcum powder according to claim 1, wherein in step S3, the mass ratio of the continuous phase solution, the dispersed phase and the plant extract solution is 10-20: 10-20: 1 to 5.
9. The preparation method of the antibacterial and anti-inflammatory children skin-care talcum powder as claimed in claim 1, wherein the mass ratio of the modified corn starch, the modified pearl powder and the functional sustained-release capsule is 30-70: 15-25: 1 to 5.
10. The antibacterial and anti-inflammatory children skin-care powder prepared by the preparation method of any one of claims 1 to 9.
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