CN114983913A

CN114983913A - Fruit acid composition and anti-dandruff oil-control shampoo product containing same

Info

Publication number: CN114983913A
Application number: CN202210665553.3A
Authority: CN
Inventors: 张昊博; 李明
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-06-13
Filing date: 2022-06-13
Publication date: 2022-09-02

Abstract

The invention relates to a fruit acid composition and an anti-dandruff oil-control shampoo product containing the same, belonging to the technical field of hair care products. In order to solve the problem that the existing shampoo containing fruit acid can not stably remove dandruff for a long time, the invention provides a fruit acid composition which contains compound natural fruit acid and compound traditional Chinese medicine extracts. The compound natural tartaric acid is rich in alpha-hydroxy acid, can mildly prevent abnormal accumulation of scalp cutin, reduces dandruff generation, has no dependence, is compounded with the compound traditional Chinese medicine extract, further enhances the bacteriostatic and dandruff removing capability of the composition, simultaneously has the anti-inflammatory effect, helps inflammatory hair follicles to quickly recover to be normal, improves excessive secretion of grease, and further realizes the effect of controlling oil. The tartaric acid composition is used for preparing an anti-dandruff oil-control shampoo product, and components such as an amino acid surfactant and the like are added, so that the hair can be more smooth and glossy on the basis of lasting mildness, anti-dandruff oil control and maintenance of scalp microecological balance.

Description

Fruit acid composition and anti-dandruff oil-control shampoo product containing same

Technical Field

The invention belongs to the technical field of hair care products, and particularly relates to a tartaric acid composition and an anti-dandruff oil-control shampoo product containing the same.

Background

Dandruff is the exfoliative keratinocytes of the scalp. Normally, keratinocytes shed very little, slowly and are not seen visibly. However, when the ecological balance of the scalp is disrupted, a large amount of immature keratinocytes are produced, and the aggregates are separated, resulting in dandruff.

The healthy scalp ecosystem is maintained by three major balances: lipid, flora and metabolic balance. When the secretion of oil and fat of scalp is unbalanced, the oil of scalp is greasy; when the scalp flora is unbalanced in environment and a large amount of harmful bacteria are bred, scalp itching can occur; the stratum corneum of the scalp is metabolized too quickly and falls off to form dandruff.

Salicylic acid is an anti-dandruff component which is put into shampoo at the earliest time, has remarkable anti-dandruff capability and is relatively cheap. However, salicylic acid has strong irritation, although the scalp cannot be felt by daily use, the scalp becomes thin and the scalp sensitivity is increased after long-term use, and dandruff is easy to relapse after the scalp is stopped.

Although the chemical anti-dandruff component has a good bactericidal effect, the bactericidal ability is too strong, so that 'killing is one thousand and eight hundred of self-damage', the beneficial flora of the scalp is also killed, the ecological environment of the scalp is unbalanced, scalp problems frequently occur for a long time, and even alopecia can be caused.

The fruit acid is used as a plant component, has the advantages of natural sterilization and dandruff removal, is mild and non-irritant, and is very friendly to the scalp of pregnant women and children. However, the existing shampoo containing fruit acid sold in the market generally has an anti-dandruff effect, and the fruit acid component is easy to dissociate in the alkaline shampoo and loses the effect, so that the anti-dandruff effect can be achieved only in a short time, and the anti-dandruff effect can not be achieved stably for a long time.

Disclosure of Invention

In order to solve the problem that the existing shampoo containing the fruit acid can not stably remove the dandruff for a long time, the invention provides a fruit acid composition and an anti-dandruff oil-control shampoo product containing the fruit acid composition.

The technical scheme of the invention is as follows:

a fruit acid composition contains compound natural fruit acid and compound traditional Chinese medicine extracts, wherein the mass ratio of the compound natural fruit acid to the compound traditional Chinese medicine extracts is 1-5: 1-5, and the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio; the compound traditional Chinese medicine extract comprises a camellia seed extract, a sophora flavescens extract, a honeysuckle extract, a galangal extract and a gallnut extract, and the mass ratio of the camellia seed extract to the sophora flavescens extract to the honeysuckle extract to the galangal extract to the gallnut extract is 5-10: 3-8: 3-5: 1-3.

Further, the extraction method of the camellia seed extract, the sophora flavescens extract, the honeysuckle extract, the galangal extract and the gallnut extract comprises the following steps:

step one, cleaning, drying and crushing camellia seeds, radix sophorae flavescentis, honeysuckle, galangal or gallnut which are traditional Chinese medicine raw materials to obtain camellia seed powder, radix sophorae flavescentis powder, honeysuckle powder, galangal powder or gallnut powder; adding 80% ethanol solution with mass volume ratio of 1:25 into the obtained camellia seed powder, radix Sophorae Flavescentis powder, flos Lonicerae powder, rhizoma Alpiniae Officinarum powder or Galla chinensis powder, and soaking for 6 hr;

step two, filling the ethanol soak solution obtained in the step one into a high-pressure-resistant sealed bag, adopting an ultrahigh-pressure extraction device, increasing the pressure born by the sealed bag to 300Mpa within 15min, continuously maintaining the pressure for 15min, then quickly relieving the pressure to the atmospheric pressure within 10-12 s, and maintaining the pressure and quickly relieving the pressure for 3 times;

and step three, taking out the ethanol soaking solution in the sealed bag obtained in the step two, filtering, centrifuging the obtained filtrate, collecting the centrifuged supernatant, and performing spray drying to obtain camellia seed extract powder, sophora flavescens extract powder, honeysuckle extract powder, galangal extract powder or gallnut extract powder.

A tartaric acid composition comprises compound natural tartaric acid, tea saponin, matrine, chlorogenic acid, galangin and gallic acid, wherein the mass ratio of the compound natural tartaric acid, the tea saponin, the matrine, the chlorogenic acid, the galangin and the gallic acid is 1-50: 1-10: 1-8: 1-5: 1-3; the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio.

A tartaric acid composition comprises composite natural tartaric acid and tea saponin slow-release particles, matrine slow-release particles, chlorogenic acid slow-release particles, galangin slow-release particles and gallic acid slow-release particles, wherein the mass ratio of the composite natural tartaric acid, the tea saponin slow-release particles, the matrine slow-release particles, the chlorogenic acid slow-release particles, the galangin slow-release particles and the gallic acid slow-release particles is 1-50: 5-70: 5-55: 5-35: 5-20; the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio.

Furthermore, the drug loading rate of the tea saponin sustained-release particles, the matrine sustained-release particles, the chlorogenic acid sustained-release particles, the galangin sustained-release particles and the gallic acid sustained-release particles is 10-15%.

Further, the preparation method of the tea saponin sustained-release particles, the matrine sustained-release particles, the chlorogenic acid sustained-release particles, the galangin sustained-release particles or the gallic acid sustained-release particles comprises the following steps:

step A, respectively preparing a sodium alginate solution and a chitosan solution with the mass concentration of 3.0%;

step B, adding theasaponin, matrine, chlorogenic acid, galangin or gallic acid into the chitosan solution obtained in the step a, and performing ultrasonic dispersion to obtain a drug-loaded chitosan solution;

step C, adding Tween-80 into the drug-loaded chitosan solution in the step b, stirring uniformly, dropwise adding the sodium alginate solution obtained in the step a into the drug-loaded chitosan solution in a stirring state, and continuously stirring;

d, shearing the stirring system obtained in the step c at a high speed of 10000-15000 rpm for 10-15 min, and collecting precipitates to obtain tea saponin sustained-release particles, matrine sustained-release particles, chlorogenic acid sustained-release particles, galangin sustained-release particles or gallic acid sustained-release particles; the average particle size of the tea saponin sustained-release particles, the matrine sustained-release particles, the chlorogenic acid sustained-release particles, the galangin sustained-release particles or the gallic acid sustained-release particles is 50-80 mu m.

A tartaric acid composition comprises composite natural tartaric acid and composite drug-loaded sustained-release particles, wherein the mass ratio of the composite natural tartaric acid to the composite drug-loaded sustained-release particles is 1-50: 5-100; the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio; the medicine carried by the composite medicine-carrying slow-release particles comprises tea saponin, matrine, chlorogenic acid, galangin and gallic acid, wherein the mass ratio of the tea saponin to the matrine to the chlorogenic acid to the galangin to the gallic acid is 1-10: 1-8: 1-5: 1-3; the drug loading amount of the composite drug-loaded slow-release particles is 10-20%.

Further, the preparation method of the composite drug-loaded sustained-release microparticle comprises the following steps:

b, adding theasaponin, matrine, chlorogenic acid, galangin and gallic acid into the chitosan solution obtained in the step a, and performing ultrasonic dispersion to obtain a composite drug-loaded chitosan solution;

step c, adding tween-80 into the composite drug-loaded chitosan solution in the step b, stirring uniformly, dropwise adding the sodium alginate solution obtained in the step a into the composite drug-loaded chitosan solution in a stirring state, and continuously stirring;

d, shearing the stirring system obtained in the step c at a high speed of 10000-15000 rpm for 10-15 min, and collecting precipitates to obtain the composite drug-loaded slow-release particles; the average particle size of the composite drug-loaded slow-release particles is 50-80 μm.

An anti-dandruff oil-control shampoo product containing a fruit acid composition, wherein the weight percentage of the fruit acid composition is 1-10%.

Further, the composition also comprises the following components in percentage by mass: 10-30% of surfactant, 1-3% of auxiliary emulsifier, 1-3% of antioxidant, 1-3% of stabilizer, 0.1-0.3% of pH regulator and the balance of deionized water.

The invention has the beneficial effects that:

the invention provides a fruit acid composition which is rich in alpha-hydroxy acid, mildly prevents keratinocyte activation, controls keratinocyte aggregation, prevents abnormal accumulation of scalp cutin, reduces dandruff generation and has no dependence. The compound traditional Chinese medicine extract in the composition can inhibit the growth of harmful microorganisms which destroy the oil balance of scalp, and particularly can obviously inhibit the proliferation of malassezia which can stimulate the scalp to generate a large amount of dandruff. The compound traditional Chinese medicine extract and the compound natural fruit acid are compounded, so that the bacteriostatic and anti-dandruff capability of the composition is further enhanced, and the composition also has an anti-inflammatory effect, helps inflamed hair follicles to quickly recover to be normal, and improves excessive secretion of grease, thereby realizing the effect of controlling oil.

The invention further provides a fruit acid composition consisting of compound natural fruit acid, theasaponin, matrine, chlorogenic acid, galangin and gallic acid, so that the concentration of effective medicinal ingredients in the composition is increased, and the overall sterilizing and inflammation diminishing capability of the composition is improved. The traditional Chinese medicine bacteriostatic components mainly aim at harmful microorganisms which destroy the ecological balance of the scalp, such as malassezia, staphylococcus aureus and the like, and can not kill beneficial microorganisms together, so that the traditional Chinese medicine bacteriostatic components are more beneficial to recovering the microecological balance of the scalp and maintaining the health of the scalp for a long time, thereby realizing the long-term stable dandruff removing and oil controlling effect.

The invention further provides a tartaric acid composition containing composite drug-loaded sustained-release particles, which is prepared into micron-level particles by taking sodium alginate and chitosan as carriers and can be absorbed by skin. The sodium alginate and the chitosan are degradable materials, the degraded products are safe and non-toxic to human bodies and have good biocompatibility, the loaded important effective ingredients are gradually released along with the degradation of the sodium alginate and the chitosan, the slow release effect is achieved, the action time of the medicine is effectively prolonged, and compared with the existing shampoo products, the slow release preparation provided by the embodiment can obviously prolong the effect of removing dandruff and controlling oil, the antibacterial effect is maintained for a long time, and the micro-ecological balance of the scalp is maintained.

The invention also provides an anti-dandruff oil-control shampoo product containing the tartaric acid composition, which is added with the amino acid surfactant, the auxiliary emulsifier and the like, and can make hair more smooth and bright on the basis of lasting mildness, anti-dandruff oil control and maintenance of micro-ecological balance of scalp.

Detailed Description

The technical solutions of the present invention are further described below with reference to the following examples, but the present invention is not limited thereto, and any modifications or equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention. The process equipment or apparatus not specifically mentioned in the following examples are conventional in the art, and if not specifically mentioned, the raw materials and the like used in the examples of the present invention are commercially available; unless otherwise specified, the technical means used in the examples of the present invention are conventional means well known to those skilled in the art.

Example 1

This example provides a fruit acid composition.

The fruit acid composition provided by the embodiment is composed of compound natural fruit acid and a compound traditional Chinese medicine extract, wherein the mass ratio of the compound natural fruit acid to the compound traditional Chinese medicine extract is 1: 1.

The composite natural fruit acid of the embodiment is composed of an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in equal mass ratio, wherein the extraction method of the egg fruit acid extract, the sugarcane fruit acid extract, the citric acid extract, the pineapple fruit acid extract and the grape fruit acid extract is as follows: filtering squeezed juice of fructus Plumeriae Acutifoliae, caulis Sacchari sinensis, fructus Citri Limoniae, fructus Ananadis Comosi or fructus Vitis Viniferae to remove impurities, purifying the filtrate with ion exchange resin, introducing the filtrate into styrene strong acid cation exchange resin, removing cations to obtain cation-removed solution, introducing the cation-removed solution into acrylic weak base anion exchange resin column at a ratio of 1.5BV/h for sufficient adsorption with resin, washing the adsorption resin with 1.5BV pure water, and resolving with 1.5BV dilute sulfuric acid with concentration of 3.0% to obtain fructus Plumeriae Acutifoliae acid extract, caulis Sacchari sinensis acid extract, citric acid extract, fructus Ananadis Comosi acid extract or fructus Vitis Viniferae acid extract.

The composite traditional Chinese medicine extract in the embodiment comprises a camellia seed extract, a sophora flavescens extract, a honeysuckle extract, a galangal extract and a gallnut extract in a mass ratio of 10:5:5:3: 1.

The compound natural fruit acid prepared by the embodiment is rich in alpha-hydroxy acid, mildly prevents the activation of keratinocytes, controls the aggregation of the keratinocytes, prevents the abnormal accumulation of scalp keratin, reduces the generation of dandruff and has no dependence. The compound traditional Chinese medicine extract can inhibit the growth of harmful microorganisms which destroy the oil balance of scalp, and particularly can obviously inhibit the proliferation of malassezia which can stimulate the scalp to generate a large amount of dandruff. According to the embodiment, the traditional Chinese medicine extract is compounded on the basis of the compound natural fruit acid, so that the bacteriostatic and anti-dandruff capacity of the composition is further enhanced, and meanwhile, the composition has an anti-inflammatory effect, helps inflamed hair follicles to quickly recover to be normal, and improves excessive secretion of grease, so that the effect of controlling oil is realized. Compared with the chemical antidandruff agent, the fruit acid composition of the embodiment is milder, does not irritate the scalp and is beneficial to scalp maintenance.

Example 2

The embodiment provides an extraction method of the camellia seed extract, the sophora flavescens extract, the honeysuckle extract, the galangal extract and the gallnut extract in the embodiment 1, which specifically comprises the following steps:

step one, cleaning and then placing the camellia seeds, the radix sophorae flavescentis, the honeysuckle, the galangal or the gallnut which are used as the traditional Chinese medicine raw materials in a vacuum drying oven at 60 ℃ for drying for 12 hours, and crushing the dried traditional Chinese medicine raw materials to 100 meshes to prepare camellia seed powder, radix sophorae flavescentis powder, honeysuckle powder, galangal powder or gallnut powder; adding 80% ethanol solution with mass volume ratio of 1:25 into the obtained camellia seed powder, radix Sophorae Flavescentis powder, flos Lonicerae powder, rhizoma Alpiniae Officinarum powder or Galla chinensis powder, and soaking for 6 hr;

and step three, taking out the ethanol soaking solution in the sealed bag obtained in the step two, filtering, centrifuging the obtained filtrate, taking the centrifuged supernatant, centrifuging again, collecting the twice centrifuged supernatant, and spray-drying to obtain camellia seed extract powder, sophora flavescens extract powder, honeysuckle extract powder, galangal extract powder and gallnut extract powder.

The embodiment adopts an ultrahigh pressure extraction process to extract the effective components in camellia seeds, radix sophorae flavescentis, honeysuckle, galangal and gallnut, and utilizes the huge osmotic pressure generated by fast pressure relief inside and outside the cells of the medicinal material to change the cell membrane structure of the medicinal material, so that the effective medicinal components in the cells efficiently permeate into the extracting solution outside the cells, and the extraction effect is more sufficient and effective.

Example 3

This example provides a fruit acid composition.

The tartaric acid composition provided by the embodiment contains compound natural tartaric acid, theasaponin, matrine, chlorogenic acid, galangin and gallic acid, wherein the mass ratio of the compound natural tartaric acid, the theasaponin, the matrine, the chlorogenic acid, the galangin and the gallic acid is 30:8:5:5:2: 1; the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio, wherein the extraction method of the egg fruit acid extract, the sugarcane fruit acid extract, the citric acid extract, the pineapple fruit acid extract and the grape fruit acid extract is as follows: filtering squeezed juice of fructus Plumeriae Acutifoliae, caulis Sacchari sinensis, fructus Citri Limoniae, fructus Ananadis Comosi or fructus Vitis Viniferae to remove impurities, purifying the filtrate with ion exchange resin, introducing the filtrate into styrene strong acid cation exchange resin, removing cations to obtain cation-removed solution, introducing the cation-removed solution into acrylic weak base anion exchange resin column at a ratio of 1.5BV/h for sufficient adsorption with resin, washing the adsorption resin with 1.5BV pure water, and resolving with 1.5BV dilute sulfuric acid with concentration of 3.0% to obtain fructus Plumeriae Acutifoliae acid extract, caulis Sacchari sinensis acid extract, citric acid extract, fructus Ananadis Comosi acid extract or fructus Vitis Viniferae acid extract.

Compared with the embodiment 1, the traditional Chinese medicine extract is directly replaced by the combination of single active ingredients, so that the concentration of the active pharmaceutical ingredients in the composition is increased, and the overall sterilizing and inflammation diminishing capability of the composition is improved. The Chinese medicinal bacteriostatic component is different from a chemical bactericide, is a component which is naturally formed by plants and has direct killing and inhibiting effects on fungi and bacteria, and comprises alkaloids, glycosides, chlorogenic acid and the like. The traditional Chinese medicine bacteriostatic component mainly aims at harmful microorganisms which destroy the ecological balance of the scalp, such as malassezia, staphylococcus aureus and the like, and can not kill beneficial microorganisms together, so that the traditional Chinese medicine bacteriostatic component is more beneficial to recovering the microecological balance of the scalp and maintaining the health of the scalp for a long time, thereby realizing the long-term stable dandruff removing and oil controlling effect, and avoiding the repeated phenomenon of dandruff even if the traditional Chinese medicine bacteriostatic component is stopped.

Example 4

The embodiment provides a tartaric acid composition, which comprises composite natural tartaric acid and theasaponin sustained-release particles, matrine sustained-release particles, chlorogenic acid sustained-release particles, galangin sustained-release particles and gallic acid sustained-release particles, wherein the drug loading rate of the theasaponin sustained-release particles, the matrine sustained-release particles, the chlorogenic acid sustained-release particles, the galangin sustained-release particles and the gallic acid sustained-release particles is 14.5%; the mass ratio of the composite natural fruit acid to the tea saponin sustained-release particles to the matrine sustained-release particles to the chlorogenic acid sustained-release particles to the galangin sustained-release particles to the gallic acid sustained-release particles is 30:55:35:35:20: 5.

The specific preparation method of each sustained-release microparticle in this embodiment includes the steps of:

step A, preparing a sodium alginate solution with the mass concentration of 3.0% from 30g of sodium alginate by using deionized water, and preparing a chitosan solution with the mass concentration of 3% from 60g of chitosan by using acetic acid with the volume concentration of 3%; the deacetylation degree of the chitosan used in the embodiment is 80-85%;

step B, adding 17g of tea saponin, matrine, chlorogenic acid, galangin or gallic acid into the obtained chitosan solution, and performing ultrasonic dispersion at 500W for 20min to obtain a drug-loaded chitosan solution;

step C, adding 10g of Tween-80 into the drug-loaded chitosan solution, stirring uniformly, dropwise adding the sodium alginate solution into the drug-loaded chitosan solution at the stirring speed of 150rpm, and continuously stirring for 12 hours;

and D, performing high-speed shearing treatment on the stirring system obtained in the step c at the rotating speed of 10000rpm, centrifuging at 5000rpm for 20min after treating for 15min, and collecting precipitates, wherein the precipitates are tea saponin sustained-release particles, matrine sustained-release particles, chlorogenic acid sustained-release particles, galangin sustained-release particles or gallic acid sustained-release particles, and the average particle size of each sustained-release particle prepared in the embodiment is 50-80 μm.

The sustained-release microparticles prepared in the embodiment are micron-sized microparticles prepared by taking sodium alginate and chitosan as carriers, and can be absorbed by skin. The sodium alginate and the chitosan are degradable materials, the degraded products are safe and non-toxic to human bodies and have good biocompatibility, the loaded important effective ingredients are gradually released along with the degradation of the sodium alginate and the chitosan, the slow release effect is achieved, the action time of the medicine is effectively prolonged, and compared with the existing shampoo products, the slow release preparation provided by the embodiment can obviously prolong the effect of removing dandruff and controlling oil, the antibacterial effect is maintained for a long time, and the micro-ecological balance of the scalp is maintained.

Example 5

The embodiment provides a tartaric acid composition, which comprises compound natural tartaric acid and compound drug-loaded sustained-release particles, wherein the mass ratio of the compound natural tartaric acid to the compound drug-loaded sustained-release particles is 20: 75.

The compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio.

The medicine carried by the composite medicine-carrying sustained-release particles comprises theasaponin, matrine, chlorogenic acid, galangin and gallic acid, wherein the mass ratio of the theasaponin to the matrine to the chlorogenic acid to the galangin to the gallic acid is 8:6:6:4: 3; the drug loading rate of the composite drug-loaded sustained-release particles is 17.5 percent

The specific preparation method of the composite drug-loaded sustained-release particles in the embodiment comprises the following steps:

step b, adding 8g of tea saponin, 6g of matrine, 6g of chlorogenic acid, 4g of galangin and 3g of gallic acid into the obtained chitosan solution, and performing 700W ultrasonic dispersion for 20min to obtain a drug-loaded chitosan solution;

and d, performing high-speed shearing treatment on the stirring system obtained in the step c at the rotating speed of 10000rpm, centrifuging for 20min at 5000rpm after treating for 15min, and collecting precipitates to obtain the composite drug-loaded sustained-release particles. The average particle size of the composite drug-loaded sustained-release particles prepared by the embodiment is 50-80 μm.

The composite drug-loaded sustained-release particle prepared by the embodiment simultaneously loads the theasaponin, the matrine, the chlorogenic acid, the galangin and the gallic acid, so that the effect of removing dandruff and controlling oil for a long time is achieved, and the preparation process of the drug-loaded sustained-release particle is simplified.

Example 6

This example provides an anti-dandruff oil control shampoo product comprising the fruit acid composition prepared in example 1, comprising the following components in percentage by mass:

4% of the fruit acid composition prepared in example 1,

20 percent of surfactant,

2 percent of auxiliary emulsifier,

1 percent of antioxidant,

1 percent of stabilizer,

0.1 percent of pH regulator,

The balance of deionized water;

the surfactant is one of or a mixture of several of sodium cocoyl methyl taurate, sodium cocoyl sarcosinate, lauramidopropyl betaine or sodium lauroyl oat amino acid in any mass ratio.

The surfactant used in this example was sodium cocoyl methyl taurate, sodium cocoyl sarcosinate, lauramidopropyl betaine and sodium lauroyl avenanthionate mixed in equal mass ratio; the auxiliary emulsifier is cetostearyl alcohol; the antioxidant is sodium ascorbyl phosphate; the stabilizer is caprylic/capric triglyceride; the pH regulator is sodium bicarbonate.

The method for preparing the anti-dandruff oil-control shampoo product containing the fruit acid composition comprises the following steps:

stirring and dissolving deionized water and an auxiliary emulsifier, heating a dissolving system to 70 ℃, adding a surfactant, stirring and dissolving, cooling to room temperature, sequentially adding an antioxidant, a stabilizer and the tartaric acid composition prepared in the example 1, stirring and mixing uniformly, adding a pH regulator, regulating the pH of the system to 5.5-6.5, standing and defoaming for 24 hours, and obtaining the dandruff-removing oil-controlling shampoo product.

Example 7

This example provides an anti-dandruff oil control shampoo product comprising the fruit acid composition prepared in example 3, comprising the following components in percentage by mass:

3.4% of the fruit acid composition prepared in example 3,

20 percent of surfactant,

2 percent of auxiliary emulsifier,

1 percent of antioxidant,

1 percent of stabilizer,

0.1 percent of pH regulator,

The balance of deionized water;

stirring and dissolving deionized water and an auxiliary emulsifier, heating a dissolving system to 70 ℃, adding a surfactant, stirring and dissolving, cooling to room temperature, sequentially adding an antioxidant, a stabilizer and the tartaric acid composition prepared in the embodiment 3, stirring and mixing uniformly, adding a pH regulator, regulating the pH of the system to 5.5-6.5, standing and defoaming for 24 hours, and obtaining the dandruff-removing oil-controlling shampoo product.

Example 8

This example provides an anti-dandruff oil-control shampoo product containing the fruit acid composition prepared in example 4, which comprises the following components in percentage by mass:

8% of the fruit acid composition prepared in example 4,

20 percent of surfactant,

2 percent of auxiliary emulsifier,

1 percent of antioxidant,

1 percent of stabilizer,

0.1 percent of pH regulator,

The balance of deionized water;

stirring and dissolving deionized water and an auxiliary emulsifier, heating a dissolving system to 70 ℃, adding a surfactant, stirring and dissolving, cooling to room temperature, sequentially adding an antioxidant, a stabilizer and the tartaric acid composition prepared in the embodiment 4, stirring and mixing uniformly, adding a pH regulator, regulating the pH of the system to 5.5-6.5, standing and defoaming for 24 hours, and obtaining the dandruff-removing oil-controlling shampoo product.

Example 9

This example provides an anti-dandruff oil control shampoo product comprising the fruit acid composition prepared in example 5, comprising the following components in percentage by mass:

9.5% of the fruit acid composition prepared in example 5,

20 percent of surfactant,

2 percent of auxiliary emulsifier,

1 percent of antioxidant,

1 percent of stabilizer,

0.1 percent of pH regulator,

The balance of deionized water;

stirring and dissolving deionized water and an auxiliary emulsifier, heating a dissolving system to 70 ℃, adding a surfactant, stirring and dissolving, cooling to room temperature, sequentially adding an antioxidant, a stabilizer and the tartaric acid composition prepared in the embodiment 5, stirring and mixing uniformly, adding a pH regulator, regulating the pH of the system to 5.5-6.5, standing and defoaming for 24 hours, and obtaining the dandruff-removing oil-controlling shampoo product.

Comparative example 1

The comparative example provides a shampoo product only containing the composite natural fruit acid in example 1, and the shampoo product specifically contains the following components in percentage by mass:

2% of the prepared composite natural fruit acid of example 1,

20 percent of surfactant,

2 percent of auxiliary emulsifier,

1 percent of antioxidant,

1 percent of stabilizer,

0.1 percent of pH regulator,

The balance of deionized water;

The surfactant used in the comparative example was sodium cocoyl methyl taurate, sodium cocoyl sarcosinate, lauramidopropyl betaine and sodium lauroyl avenanthionate mixed in equal mass ratio; the auxiliary emulsifier is cetostearyl alcohol; the antioxidant is sodium ascorbyl phosphate; the stabilizer is caprylic/capric triglyceride; the pH regulator is sodium bicarbonate.

The preparation method of the anti-dandruff oil-control shampoo product containing the fruit acid composition comprises the following steps:

stirring and dissolving deionized water and an auxiliary emulsifier, heating a dissolving system to 70 ℃, adding a surfactant, stirring and dissolving, cooling to room temperature, sequentially adding an antioxidant, a stabilizer and the composite natural fruit acid of the embodiment 1, stirring and mixing uniformly, adding a pH regulator, regulating the pH of the system to 5.5-6.5, standing and defoaming for 24 hours, and obtaining the shampoo product.

Example 10

This example examined the bacteriostatic effect of the shampoo products provided in examples 6, 7, 8, 9 and comparative example 1 on malassezia.

The specific test method comprises the following steps:

1. culturing malassezia furfur: expanding culture of Malassezia furfur by conventional culture method to obtain bacterial suspension, diluting viable bacteria number of the bacterial suspension with normal saline to obtain viable bacteria number of 10 ⁶ ～10 ⁷ cfu/mL of bacterial suspension;

2. the zone of inhibition test: taking 0.5mL of malassezia furfur bacterial suspension, coating the suspension on a plate culture medium with the diameter of 12cm, respectively dipping the shampoo products provided in the examples 6, 7, 8 and 9 and the comparative example 1 by using sterilized qualitative filter paper discs, sticking the qualitative filter paper discs dipped with the shampoo products on the surface of the plate culture medium coated with bacteria, correspondingly placing a piece of qualitative filter paper only dipped with sterile water on each plate culture medium as a control, and setting 3 groups of parallel controls for each shampoo sample. The culture was carried out at a constant temperature of 32 ℃ for 7 days, and the diameter of the zone of inhibition was measured and recorded.

The zone of inhibition results showed that the shampoo of example 6 had an average diameter of zone of inhibition of 21.3 + -1.1 mm, the shampoo of example 7 had an average diameter of zone of inhibition of 23.5 + -0.7 mm, the shampoo of example 8 had an average diameter of zone of inhibition of 18.6 + -2.1 mm, the shampoo of example 9 had an average diameter of zone of inhibition of 19.3 + -1.3 mm, and the shampoo of comparative example 1 had an average diameter of zone of inhibition of 15.3 + -1.5 mm.

In examples 6 to 9 and comparative example 1, the concentration of the composite natural fruit acid is 2%, but the diameters of the inhibition zones are greatly different, and from the aspect of the inhibition effect, example 7 is greater than example 6 is greater than example 9 is greater than example 8 is greater than comparative example 1; the reason why the inhibition zones of examples 8 and 9 are smaller than those of examples 6 and 7 is that the sustained-release microparticles are not completely released due to the effective ingredients. As can be seen from the comparison of the inhibition zone data, the composite traditional Chinese medicine extract, the traditional Chinese medicine antibacterial component and the composite drug-loaded slow-release particles can obviously improve the inhibition effect of the shampoo product on malassezia furfur.

Example 11

This example examines the anti-dandruff and oil control effects of shampoo products provided in examples 6, 7, 8, 9 and comparative example 1.

240 volunteers, 100 men and women, 20-40 years old are selected, all belong to oily hair, and have the problems of oil secretion, folliculitis and dandruff. Volunteers were randomly divided into 6 groups of 40, and shampooed with each of the example 6, 7, 8, 9, comparative example 1, and ludeng TSal salicylic acid anti-dandruff shampoo, every two days for one month, and after the application was stopped, the same brand of mild shampoo without anti-dandruff ingredients was used in a unified manner. The anti-dandruff oil control effect was recorded on the day of rest and one month after rest, respectively.

The evaluation standard of the effect of removing dandruff and controlling oil is as follows: obviously improved (the scurf is obviously reduced, the folliculitis is basically cured, the oil secretion is normal), improved (the scurf is partially reduced, the folliculitis is improved, the hair oil interval time is long), and ineffective (the problems of the scurf, the folliculitis and the oil secretion disorder are not changed).

The effect of removing dandruff and controlling oil is displayed, and the patient stops using the day: 35, 3 good and 2 invalid persons were significantly improved using the group of anti-dandruff, oil-control shampoo products of example 6; 37, 3 and 0 significantly improved using the anti-dandruff oil control shampoo product group of example 7; 35, 5 good and 0 invalid persons were significantly improved using the group of anti-dandruff oil control shampoo products of example 8; the group of anti-dandruff oil control shampoo products of example 9 was used to significantly improve 38, with 2 good ones and 0 invalid; the shampoo product group of comparative example 1 gave a significant improvement of 25, 10, and 5.

After one month of rest: 25, 9 improvement and 6 ineffectiveness of the group of anti-dandruff, oil-controlling shampoo products from example 6 were significantly improved; 24, 10 improvement and 6 ineffectiveness in using the anti-dandruff oil control shampoo product group of example 7; 30, 8 and 2 of the anti-dandruff oil-control shampoo product groups of the example 8 were used for significant improvement; 32, 7 improvement and 1 ineffectiveness in using the anti-dandruff oil control shampoo product group of example 9; the shampoo product group of comparative example 1 gave a significant improvement of 5, 10, 25.

The anti-dandruff oil-control effect in the day of non-use is obviously superior to that in the comparative example 1, and the anti-dandruff oil-control effects in the examples 6 to 9 are obviously superior to that in the comparative example 1, so that the compound traditional Chinese medicine extract and the compound natural tartaric acid are compounded, the bacteriostatic and anti-dandruff capacity of the composition is further enhanced, and the anti-inflammatory effect is achieved, so that the inflamed hair follicles are rapidly restored to be normal, and the excessive secretion of grease is improved, so that the oil-control effect is realized. It can be seen from the anti-dandruff oil-controlling effect of the shampoo product with the sustained-release particles that the anti-dandruff oil-controlling effect lasts longer by one month of the inactivation.

Claims

1. A fruit acid composition is characterized by containing compound natural fruit acid and compound traditional Chinese medicine extracts, wherein the mass ratio of the compound natural fruit acid to the compound traditional Chinese medicine extracts is 1-5: 1-5, and the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio; the composite traditional Chinese medicine extract comprises a camellia seed extract, a sophora flavescens extract, a honeysuckle extract, a galangal extract and a gallnut extract, and the mass ratio of the camellia seed extract to the sophora flavescens extract to the honeysuckle extract to the galangal extract to the gallnut extract is 5-10: 3-8: 3-5: 1-3.

2. The fruit acid composition as claimed in claim 1, wherein the camellia seed extract, the sophora flavescens extract, the honeysuckle extract, the galangal extract and the gallnut extract are extracted by a method comprising the following steps:

and step three, taking out the ethanol soaking solution in the sealed bag obtained in the step two, filtering, centrifuging the obtained filtrate, collecting the centrifuged supernatant, and spray-drying to obtain camellia seed extract powder, sophora flavescens extract powder, honeysuckle extract powder, galangal extract powder or gallnut extract powder.

3. A tartaric acid composition is characterized by comprising compound natural tartaric acid, tea saponin, matrine, chlorogenic acid, galangin and gallic acid, wherein the mass ratio of the compound natural tartaric acid, the tea saponin, the matrine, the chlorogenic acid, the galangin and the gallic acid is 1-50: 1-10: 1-8: 1-5: 1-3; the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio.

4. A tartaric acid composition is characterized by comprising composite natural tartaric acid and tea saponin slow-release particles, matrine slow-release particles, chlorogenic acid slow-release particles, galangin slow-release particles and gallic acid slow-release particles, wherein the mass ratio of the composite natural tartaric acid, the tea saponin slow-release particles, the matrine slow-release particles, the chlorogenic acid slow-release particles, the galangin slow-release particles and the gallic acid slow-release particles is 1-50: 5-70: 5-55: 5-35: 5-20; the compound natural fruit acid comprises an egg fruit acid extract, a sugarcane fruit acid extract, a citric acid extract, a pineapple fruit acid extract and a grape fruit acid extract in any mass ratio.

5. The fruit acid composition according to claim 1, wherein the drug loading rate of the tea saponin sustained-release particles, the matrine sustained-release particles, the chlorogenic acid sustained-release particles, the galangin sustained-release particles and the gallic acid sustained-release particles is 10-15%.

6. The fruit acid composition according to claim 4 or 5, wherein the preparation method of the tea saponin sustained-release particles, the matrine sustained-release particles, the chlorogenic acid sustained-release particles, the galangin sustained-release particles or the gallic acid sustained-release particles comprises the following steps:

7. The tartaric acid composition is characterized by comprising compound natural tartaric acid and compound drug-loaded slow-release particles, wherein the mass ratio of the compound natural tartaric acid to the compound drug-loaded slow-release particles is 1-50: 5-100; the composite natural tartaric acid comprises an egg tartaric acid extract, a sugarcane tartaric acid extract, a lemon tartaric acid extract, a pineapple tartaric acid extract and a grape tartaric acid extract in any mass ratio; the medicine carried by the composite medicine-carrying slow-release particles comprises tea saponin, matrine, chlorogenic acid, galangin and gallic acid, wherein the mass ratio of the tea saponin to the matrine to the chlorogenic acid to the galangin to the gallic acid is 1-10: 1-8: 1-5: 1-3; the drug loading amount of the composite drug-loaded slow-release particles is 10-20%.

8. The fruit acid composition of claim 7, wherein the preparation method of the composite drug-loaded sustained-release microparticles comprises the following steps:

d, shearing the stirring system obtained in the step c at a high speed of 10000-15000 rpm for 10-15 min, and collecting precipitates to obtain the composite drug-loaded slow-release particles; the average particle size of the composite drug-loaded sustained-release particles is 50-80 μm.

9. An anti-dandruff oil-control shampoo product comprising the fruit acid composition according to any one of claims 1 to 8, wherein the fruit acid composition is present in an amount of 1 to 10% by weight.

10. The anti-dandruff oil-control shampoo product containing the fruit acid composition according to claim 9, characterized by further comprising the following components in percentage by mass: 10-30% of surfactant, 1-3% of auxiliary emulsifier, 1-3% of antioxidant, 1-3% of stabilizer, 0.1-0.3% of pH regulator and the balance of deionized water.