CN116019903A - Preparation for soothing liver and improving feed absorptivity and preparation method thereof - Google Patents
Preparation for soothing liver and improving feed absorptivity and preparation method thereof Download PDFInfo
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- CN116019903A CN116019903A CN202211631802.3A CN202211631802A CN116019903A CN 116019903 A CN116019903 A CN 116019903A CN 202211631802 A CN202211631802 A CN 202211631802A CN 116019903 A CN116019903 A CN 116019903A
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Abstract
The invention discloses a preparation for soothing liver and improving feed absorptivity and a preparation method thereof, wherein the preparation is prepared from the following raw materials in parts by weight: 3-5 parts of bile acid, 1-3 parts of choline chloride, 3-5 parts of dried orange peel, 1-3 parts of curcumin, 2-4 parts of xylanase, 1-3 parts of trypsin, 1-1.5 parts of gelatin solution of 2-8 g/L and 2-2.5 parts of poloxamer 188. The invention adopts the W/O/W composite emulsion, has the directionality of lymphatic system in vivo, can be selectively distributed in organs with rich reticuloendothelial systems such as liver, lung, kidney, spleen and the like, and greatly improves the curative effect of the medicine.
Description
Technical Field
The invention belongs to the field of feed additives, and particularly relates to a preparation for soothing liver and improving feed absorptivity and a preparation method thereof.
Background
Trypsin has many anti-nutrition absorption factors in the feed to influence the absorption of animal proteins, and pancreatic protease is added into the feed to effectively play a role in resisting the nutrition factors and improve the digestion and absorption capacity of animals to the proteins.
Xylanase, which can destroy the integrity of anti-nutritional factors, reduce the viscosity of raw materials and promote the digestion and absorption of feed nutrients by animals. The xylanase is added into the daily ration to promote the growth of livestock and poultry, and the activity of endogenous digestive enzymes and the conversion rate of feed are improved to damage plant cell walls so as to promote nutrient digestion and absorption, improve intestinal morphology and structure, reduce the number of intestinal microorganisms and reduce the incidence rate of livestock and poultry.
Bile acids, which promote digestion and absorption of lipids and lipid-soluble substances; can regulate cholesterol metabolism; has effects in soothing liver, promoting function of gallbladder, and removing toxic substances; bile acid can directly destroy cell membrane of harmful bacteria and inhibit growth and reproduction of bacteria. The bile acid can improve the activities of superoxide dismutase, glutathione peroxide and glutathione reductase, effectively remove various endotoxins and free radicals in animal bodies, protect the integrity and functions of liver cells, eliminate bile stasis, discharge a plurality of medicines, heavy metals, mycotoxins and other harmful substances from bile, detoxify and maintain animal health.
Curcumin can repair damaged liver cells, improve liver parenchymal damage and increase secretion of bile, thereby playing a role in protecting liver and promoting bile flow; has good antibacterial effect on Staphylococcus aureus, and also has antiinflammatory and antioxidant effects.
The volatile oil component in the dried orange peel can enhance the activities of pepsin and pancreatin, so that the digestibility of crude protein in the feed is improved; can improve immune organ index; the cell membrane is protected from oxidative damage caused by free radicals by blocking the oxidation reaction by inhibiting the chain transfer process of the free radical chain.
Choline chloride can promote the resynthesis of amino acid in animals, improve the immunity of animals and the absorption capacity of nutrients, thereby reducing the probability of illness. Choline chloride is commonly used for pigs, cattle, chickens and fish and shrimp, and can improve the quality, safety and nutritional value of meat products and egg products while improving the physique of animals. The targeting feature of the emulsion is its affinity to lymph. The W/O/W type composite emulsion can be used as a targeting drug delivery system and a slow release drug delivery system and as a carrier of water-soluble drugs, so as to avoid the damage of the drugs by gastrointestinal fluids and facilitate the drugs to enter the lymphatic system.
The invention adopts the W/O/W type composite emulsion, wherein the tangerine peel adopts a percolation method to extract active ingredients such as volatile oil, and adopts a reasonable process to be added into the emulsion, the whole formula not only can activate the liver function, but also has the function of improving the feed utilization rate, and simultaneously, after the medicine is prepared into the composite emulsion, the aim of slow release and controlled release can be achieved, and the medicine has the directionality of lymphatic system in vivo, can be selectively distributed in organs with rich reticuloendothelial systems such as liver, lung, kidney, spleen and the like, and greatly improves the curative effect of the medicine.
Disclosure of Invention
The invention aims to provide a preparation for soothing liver and improving feed absorptivity.
The second object of the present invention is to provide a method for preparing the above preparation.
A third object of the present invention is to provide the effect of the above formulation on the performance of dairy cows, i.e., the above formulation can increase milk yield of dairy cows.
In order to achieve the above purpose, the invention adopts the following technical scheme:
a preparation for soothing liver and improving feed absorptivity is prepared from the following raw materials in parts by weight: 3-5 parts of bile acid, 1-3 parts of choline chloride, 3-5 parts of dried orange peel, 1-3 parts of curcumin, 2-4 parts of xylanase, 1-3 parts of trypsin, 1-1.5 parts of gelatin solution of 2-8 g/L and 2-2.5 parts of poloxamer 188.
Preferably, the gelatin solution has a concentration of 5g/L.
The preparation method comprises the following steps:
(1) Adding dried orange peel coarse powder into ethanol, soaking for 20-30 hours, percolating at a speed of 3-5 ml per minute, collecting percolate, standing, taking supernatant, adding curcumin, and dissolving to obtain a solution (1) for later use;
(2) Adding xylanase, trypsin and choline chloride into purified water, dissolving, adding poloxamer 188, stirring and dissolving to obtain a solution (2);
(3) Adding bile acid into oil, heating to 45-50deg.C, dissolving, adding gelatin solution and solution (2), homogenizing by a homogenizer, adding solution (1) and purified water, slowly stirring, homogenizing by a homogenizer, and adding.
Further, in the step (1), the dosage ratio of the dried orange peel coarse powder to the ethanol is 3-5g to 40mL; the ethanol is 50-75 v% ethanol, and the dosage ratio of curcumin to supernatant is 1-3 g/30 mL.
Further, in the step (2), the ratio of the sum of the mass of xylanase, trypsin and choline chloride to purified water is 4-10 g/30 mL.
In the step (3), the grease is soybean oil or coconut oil, and the dosage ratio of bile acid, grease and purified water is 3-5g:30 mL:30-40 mL.
Further, in the step (3), the pressure during homogenization of the homogenizer is 1000 Bar to 2000Bar, and the homogenization time is 5 to 10 minutes.
In the application, the bile acid can be used as a main medicine component and also has the function of the emulsifier, so that the dosage of the emulsifier is reduced.
The using method of the feed additive comprises the following steps: can be mixed with water 100kg per 100ml preparation for long term use.
The invention has the advantages and beneficial effects that: (1) The process used by the invention is suitable for production and can be stored for 12 months at normal temperature; (2) The invention adopts the W/O/W composite emulsion, has the directionality of lymphatic system in vivo, can be selectively distributed in organs with rich reticuloendothelial systems such as liver, lung, kidney, spleen and the like, and greatly improves the curative effect of the medicine; (3) According to the characteristics of the nutritional ingredients of the feed, the ingredients for promoting the absorption and decomposition of anti-nutritional molecules of the feed in the body are added, so that the feed absorptivity is further improved; (4) The invention is easy to be absorbed after entering the organism, and is convenient for clinical administration, suitable for group administration, and saves manpower and material resources.
Detailed Description
The present invention will be further described by way of examples, but the scope of the present invention is not limited thereto. The preparation process of the gelatin solution in the invention is as follows: gelatin is dissolved in purified water to prepare gelatin solution with concentration of 5g/L.
Example 1 preparation of feed absorption Rate improving preparation for soothing liver
The specific formula comprises the following steps: 3g of bile acid, 3g of choline chloride, 3g of dried orange peel, 3g of curcumin, 2g of xylanase, 3g of trypsin, 1g of gelatin solution with the concentration of 5g/L, 188.5 g of poloxamer, a proper amount of 60% ethanol and a proper amount of purified water.
The preparation method comprises the following steps:
(1) Adding pericarpium Citri Tangerinae coarse powder into 40ml60v% ethanol, soaking for 24 hr, slowly percolating at a rate of 3ml per minute, collecting percolate, standing, collecting supernatant 30ml, adding curcumin, and dissolving to obtain solution (1);
(2) Adding xylanase, trypsin and choline chloride into 30ml of purified water, dissolving, adding poloxamer 188, and stirring for dissolving to obtain a solution (2);
(3) 30ml of soybean oil is taken, bile acid is added, the temperature is heated to 50 ℃, 5g/L of gelatin solution and solution (2) are added after dissolution, after homogenization for 10 minutes by a homogenizer 1000 Bar, solution (1) and purified water are added, stirring is slowly and rapidly carried out, after uniform stirring, the mixture is added into the homogenizer again, and after homogenization for 10 minutes by 1000 Bar, the preparation of the invention is obtained.
Example 2 preparation of feed absorption Rate improving preparation for soothing liver
The specific formula comprises the following steps: 5g of bile acid, 1g of choline chloride, 5g of dried orange peel, 1g of curcumin, 4g of xylanase, 1g of trypsin, 1.5g of gelatin solution of 5g/L, 188 g of poloxamer, a proper amount of 60v% ethanol and a proper amount of purified water.
The preparation method comprises the following steps:
(1) Adding pericarpium Citri Tangerinae coarse powder into 40ml60v% ethanol, soaking for 24 hr, slowly percolating at a rate of 3ml per minute, collecting percolate, standing, collecting supernatant 30ml, adding curcumin, and dissolving to obtain solution (1);
(2) Adding xylanase, trypsin and choline chloride into 30ml of purified water, dissolving, adding poloxamer 188, and stirring for dissolving to obtain a solution (2);
(3) 30ml of coconut oil is taken, bile acid is added, the temperature is heated to 45 ℃, 5g/L of gelatin solution and solution (2) are added after dissolution, after homogenization for 5 minutes by a homogenizer 2000Bar, solution (1) and purified water 35ml are added, stirring is slowly accelerated, after uniform stirring, the mixture is added into the homogenizer again, and after homogenization for 5 minutes by 2000Bar, the preparation of the invention is obtained.
Example 3 preparation of feed absorption Rate improving preparation for soothing liver
The specific formula comprises the following steps: 4g of bile acid, 2g of choline chloride, 4g of dried orange peel, 2g of curcumin, 3g of xylanase, 2g of trypsin, 1.2g of gelatin solution with the concentration of 5g/L, 2.3g of poloxamer 188, a proper amount of 60v% ethanol and a proper amount of purified water.
The preparation method comprises the following steps:
(1) Adding pericarpium Citri Tangerinae coarse powder into 40ml60v% ethanol, soaking for 24 hr, slowly percolating at a rate of 3ml per minute, collecting percolate, standing, collecting supernatant 30ml, adding curcumin, and dissolving to obtain solution (1);
(2) Adding xylanase, trypsin and choline chloride into 30ml of purified water, dissolving, adding poloxamer 188, and stirring for dissolving to obtain solution (2).
(3) 30ml of soybean oil is taken, bile acid is added, the temperature is heated to 50 ℃, 5g/L of gelatin solution and solution (2) are added after dissolution, after 8 minutes of homogenization by a homogenizer 1500 Bar, 35ml of solution (1) and purified water are added, stirring is slowly and rapidly carried out, after even stirring, the mixture is added into the homogenizer again, and after 8 minutes of homogenization by 1500 Bar, the preparation of the invention is obtained.
Example 4 preparation of a control for soothing liver and increasing feed absorption Rate formulation
The preparation method comprises the following steps: drying and crushing 4g of dried orange peel, sieving with a 60-mesh sieve, adding 4g of bile acid, 2g of choline chloride, 2g of curcumin, 3g of xylanase, 2g of trypsin and 83g of anhydrous glucose, and uniformly mixing to obtain the reference substance.
EXAMPLE 5 Effect of the formulation of the invention on the lactation performance of cows
The method is carried out according to the following steps:
drug and reagent
Test drug: the formulations prepared in examples 1, 2, 3;
control drug: the formulation prepared in example 4
Blank group: no preparation is added
(II) test method
(1) And (3) test design: the 150 cows for test with similar lactation amount are randomly selected and randomly divided into 5 groups of 30 cows, wherein 3 test groups, 1 control group and 1 blank group.
The 3 test groups and the 1 control group were each as follows: mixed drink, 100kg of water is added into each 100ml of preparation for administration, the preparation is continuously used for 3 months, and 5 groups adopt free ingestion, epidemic prevention and management measures which are consistent with daily use. The test animals were fed a basal diet.
The observation record items are: milk composition and lactation yield determination.
Measurement of milk components: the test group, the control group and the blank group are sampled 1 time every 3 days, and the milk samples with the same amount are respectively taken in the morning, the midnight and the evening to be mixed and the milk ingredient indexes such as milk fat percentage, milk protein, milk solid, non-protein nitrogen, somatic cells and the like are detected.
And (3) calculating the lactation yield: and counting the lactation yield of the test group and the control group for 1 time every day, continuously counting for 3 months, and calculating the average lactation yield of the population month.
(2) Results and analysis
Table 1 comparison of lactation yield
Table 1 shows: the invention can obviously increase the milk yield of cows, the average milk yield of each cow per day of test groups 1, 2 and 3 months is 15.30 and kg, the average milk yield of a control group per day is 13.45kg, and the average milk yield of a blank group per day is 11.43kg. The test group was 13.76% higher than the control group and 33.86% higher than the blank group.
TABLE 2 comparison of milk components
As can be seen from table 2: test groups 1, 2, 3 showed significantly higher milk fat percentage, milk protein and milk solids than control and blank groups, while non-protein and somatic cells were significantly reduced.
The improvement of the lactation yield and the milk fat percentage of the dairy cows has a great relation with the utilization rate of the feed and the production performance of the dairy cows, so that the invention has obvious effect on improving the utilization rate of the feed.
Claims (9)
1. The preparation for soothing the liver and improving the feed absorptivity is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of bile acid, 1-3 parts of choline chloride, 3-5 parts of dried orange peel, 1-3 parts of curcumin, 2-4 parts of xylanase, 1-3 parts of trypsin, 1-1.5 parts of gelatin solution of 2-8 g/L and 2-2.5 parts of poloxamer 188.
2. The formulation for soothing liver to improve feed absorption according to claim 1, wherein the gelatin solution has a concentration of 5g/L.
3. The preparation method of the preparation for soothing liver and improving feed absorptivity according to claim 1 or 2, characterized in that the preparation process is as follows:
(1) Adding dried orange peel coarse powder into ethanol, soaking for 20-30 hours, percolating at a speed of 3-5 ml per minute, collecting percolate, standing, taking supernatant, adding curcumin, and dissolving to obtain a solution (1) for later use;
(2) Adding xylanase, trypsin and choline chloride into purified water, dissolving, adding poloxamer 188, stirring and dissolving to obtain a solution (2);
(3) Adding bile acid into oil, heating to 45-50deg.C, dissolving, adding gelatin solution and solution (2), homogenizing by a homogenizer, adding solution (1) and purified water, slowly stirring, homogenizing by a homogenizer, and adding.
4. The method for preparing a formulation for soothing liver and improving feed absorption rate according to claim 3, wherein in the step (1), the ratio of the dried orange peel coarse powder to the ethanol is 3-5 g/40 ml; the ethanol is 50-75 v% ethanol, and the dosage ratio of curcumin to supernatant is 1-3 g/30 mL.
5. The method for preparing a preparation for soothing liver and improving feed absorptivity according to claim 3, wherein in the step (2), the ratio of the sum of the mass of xylanase, trypsin and choline chloride to purified water is 4-10 g/30 mL.
6. The method for preparing the preparation for soothing liver and improving feed absorptivity according to claim 3, wherein in the step (3), the grease is soybean oil or coconut oil, and the dosage ratio of bile acid, grease and purified water is 3-5g:30 mL:30-40 mL.
7. The method for preparing a preparation for soothing liver and improving feed absorptivity according to claim 3, wherein in the step (3), the pressure during homogenization of the homogenizer is 1000 Bar to 2000Bar, and the homogenization time is 5 minutes to 10 minutes.
8. Use of a formulation for soothing the liver and increasing the feed absorption according to claim 1 or 2 for increasing milk yield in dairy cows.
9. The use according to claim 8, wherein 100kg of water is added per 100ml of the formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211631802.3A CN116019903A (en) | 2022-12-19 | 2022-12-19 | Preparation for soothing liver and improving feed absorptivity and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211631802.3A CN116019903A (en) | 2022-12-19 | 2022-12-19 | Preparation for soothing liver and improving feed absorptivity and preparation method thereof |
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| CN116019903A true CN116019903A (en) | 2023-04-28 |
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| CN202211631802.3A Pending CN116019903A (en) | 2022-12-19 | 2022-12-19 | Preparation for soothing liver and improving feed absorptivity and preparation method thereof |
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